cosyntropin and Lipoma

In a 35-year old woman presenting familial multiple lipomatosis, spastic paraparesis developed and became worse under tetracosactide therapy. Signs of spinal cord compression at T3 were present. CT and MRI revealed a fat-containing epidural tumour (angiolipoma). The association of angiolipoma with familial multiple lipomatosis has not yet been reported. This association supports the theory that angiolipomas are hamartomatous lesions. The deterioration observed under tetracosactide suggests that iatrogenic epidural lipomatosis is due to the development of a pre-existing lipoma.

Topics: Adult; Cosyntropin; Diagnosis, Differential; Epidural Neoplasms; Female; Hemangioma; Humans; Lipoma; Lipomatosis, Multiple Symmetrical; Magnetic Resonance Imaging; Multiple Sclerosis; Spinal Cord Compression