cosyntropin and Eosinophilia

2 cases one of polyneuropathy and one of funicular myelosis, in which myelography was performed, are reported. After the insertion of the contrast medium an increase of eosinophil leucocytes was observed. In one case an additional increase of IgG and IgA, as well as a penetration of macromolecular proteins and an increase of the total protein, was detected. The second case showed an increase in haptoglobulin in addition to the cellular reaction described. After removal of the contrast medium, the CSF became normal in both cases. These changes were on one hand interpreted as a functional lesion of the barrier, and on the other hand as a special cellular and humoral immune reaction. This could be distinctly detected in the lumbar CSF while in the suboccipital CSF there was only an indication of it. This emphasizes the assumption of a pathological reaction in the section of the cerebrospinal region that was in contact with the contrast medium (allergen-hyperergic reaction of the vascular fibrous tissue of the leptomeninges). No marked changes were observed in the serum.

Topics: Adult; Blood Cell Count; Cerebrospinal Fluid; Cerebrospinal Fluid Proteins; Contrast Media; Cosyntropin; Eosinophilia; Female; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Iophendylate; Leukocyte Count; Lymphocytes; Male; Myelography