cosyntropin has been researched along with Dyskinesia--Drug-Induced* in 1 studies
1 other study(ies) available for cosyntropin and Dyskinesia--Drug-Induced
| Article | Year |
|---|---|
Morphine and beta-endorphin antagonize posture and locomotor disorders induced by the injection of ACTH 1-24 in the rat locus coeruleus.
The unilateral microinjection of ACTH 1-24 (20 nmol) into the locus coeruleus (LC) produced a long lasting (2-3 hr) posture asymmetry and movement disorder in all rats tested. This response was readily suppressed by the subsequent local microinjection of an equimolar dose of beta-endorphin or morphine or by the intraperitoneal injection of morphine sulphate (50 mg/kg). Microinjection of naloxone (20 nmol) into the LC produced the above syndrome in a lower percentage of animals. The results support the hypothesis that ACTH peptides and opioids play opposite roles in the control of different brain functions. Topics: Adrenocorticotropic Hormone; Animals; beta-Endorphin; Cosyntropin; Dyskinesia, Drug-Induced; Endorphins; Locus Coeruleus; Male; Microinjections; Morphine; Naloxone; Posture; Rats; Rats, Inbred Strains | 1986 |