corylin and Sepsis

Corylin is a main compound isolated from Psoralea corylifolia L. (Fabaceae). A variety of pharmacological effects such as antioxidant, anti-proliferation, and anti-inflammatory properties of corylin have been reported. Nevertheless, the effect of corylin in microbial infection and sepsis remains unclear. In the present study, we investigated the anti-inflammatory effects of corylin. Our experimental results demonstrated that corylin inhibited the production of TNF-α, IL-6 and NO by both LPS-activated RAW 264.7 cells and LPS-activated murine peritoneal macrophages. Moreover, corylin suppressed the expression levels of iNOS and COX-2, reduced the production of PGE

Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Cyclooxygenase 2; Cytokines; Dinoprostone; Flavonoids; Inflammation Mediators; Kidney; Lipopolysaccharides; Liver; Macrophages; Macrophages, Peritoneal; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Phosphorylation; RAW 264.7 Cells; Sepsis; Signal Transduction