cortodoxone and Uterine-Neoplasms

To study the effect of endogenous steroids on the presence of uterine leiomyomas.. Urine samples of 27 premenopausal women with leiomyomas and 25 age-matched healthy premenopausal women were collected. The concentration of estrogens and androgens in the urine samples of the two groups were determined using a gas chromatography mass spectrometer and the two groups were compared. To study metabolic changes in patients indirectly, the concentration ratios of precursor metabolite to product metabolite of the two groups were also compared.. Urinary concentrations of 17beta-estradiol, 5-androstene-3beta, 16beta, 17beta, triol, 11-keto-ethiocholanolone, 11beta-hydroxy-androsterone, 11beta-hydroxy-etiocholanolone, THS, THA, THE, alpha-cortol and beta-cortol were significantly higher in patients than in controls. The concentration ratios of 17beta-estradiol/estrone and 11/beta-hydroxy-ethiocholanolone/11beta-hydroxy-androsterone increased in patients.. The presence of uterine leiomyomas correlates with an increase in urinary concentrations of estrogens and androgens, and it appears to be caused by a decrease in patients' metabolism of steroids.

Topics: Adult; Androgens; Androstenols; Androsterone; Case-Control Studies; Corticosterone; Cortodoxone; Dehydroepiandrosterone; Estradiol; Estrogens; Estrone; Etiocholanolone; Female; Gas Chromatography-Mass Spectrometry; Humans; Leiomyoma; Middle Aged; Pregnanes; Premenopause; Tetrahydrocortisone; Uterine Neoplasms

Cortiphen and cyclophosphamide were studied for their effect on the mixed uterus sarcoma induced primarily by 1,2-dimethylhydrazine and oestradiol-dipropionate in CBA mice and its transplants. Their inhibitory action on the growth of these tumours is established.

Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents; Carcinogens; Corticosterone; Cyclophosphamide; Dimethylhydrazines; Drug Combinations; Estradiol; Female; Methylhydrazines; Mice; Mice, Inbred CBA; Nitrogen Mustard Compounds; Sarcoma, Experimental; Uterine Neoplasms

The antitumour activity of cortiphen synthesized at the All-Union Cancer Research Centre of the USSR Academy of Medical Sciences was studied on human tumour strains transplanted into nude mice and rats. Cortiphen was found to possess an expressed activity to kidney cancer, cancer of corpus uteri, chorionepithelioma, fibrosarcoma. Two strains of colon adenocarcinoma out of three have displayed an expressed sensitivity to cortiphen, while melanoma and Jewing sarcoma strains proved to be weakly sensitive to the preparation.

Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Choriocarcinoma; Colonic Neoplasms; Corticosterone; Drug Combinations; Female; Fibrosarcoma; Humans; Kidney Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Nitrogen Mustard Compounds; Rats; Rats, Nude; Tumor Cells, Cultured; Uterine Neoplasms