cortodoxone has been researched along with Anemia--Sickle-Cell* in 1 studies
1 other study(ies) available for cortodoxone and Anemia--Sickle-Cell
Article | Year |
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Pituitary-adrenal axis function in sickle cell anemia and its relationship to leukocyte alkaline phosphatase.
The function of the pituitary-adrenal axis and leukocyte alkaline phosphatase activity were evaluated in eight patients with sickle cell disease during a painful crisis and when crisis-free. The leukocyte alkaline phosphatase (LAP) score did not increase during crisis; the scores were in the low-normal range during crisis and noncrisis periods. Insulin-induced hypoglycemia produced normal growth hormone responses during both crisis and crisis-free periods. Plasma cortisol concentrations were diminished in the crisis group. Also impaired was 11-deoxycortisol production in both groups after metyrapone. These findings indicate that a mild defect in the hypothalamic-pituitary-adrenal axis exists in sickle cell disease patients. Topics: Adult; Alkaline Phosphatase; Anemia, Sickle Cell; Blood Glucose; Cortodoxone; Female; Growth Hormone; Humans; Hydrocortisone; Insulin; Leukocytes; Male; Metyrapone; Pituitary-Adrenal System; Thalassemia | 1980 |