corticosterone has been researched along with Hemorrhagic Shock in 25 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " Immediately after the completion of resuscitation, as well as 24 and 48 h thereafter, the animals received either vehicle, 10 mg/kg body weight (BW) flutamide or 25 mg/kg BW flutamide subcutaneously." | 7.69 | Flutamide: a novel agent for restoring the depressed cell-mediated immunity following soft-tissue trauma and hemorrhagic shock. ( Angele, MK; Ayala, A; Chaudry, IH; Cioffi, WG; Wichmann, MW, 1997) |
| "The effects of surgical trauma and hemorrhagic shock on the circadian rhythmicity of corticosteroid secretion in the rat were investigated." | 5.26 | Circadian periodicity of plasma corticosterone levels in rats subjected to hemorrhagic shock and surgical trauma. ( Jackson, BT; Levine, RL; Lothrop, DA; McIntosh, TK, 1980) |
| " Immediately after the completion of resuscitation, as well as 24 and 48 h thereafter, the animals received either vehicle, 10 mg/kg body weight (BW) flutamide or 25 mg/kg BW flutamide subcutaneously." | 3.69 | Flutamide: a novel agent for restoring the depressed cell-mediated immunity following soft-tissue trauma and hemorrhagic shock. ( Angele, MK; Ayala, A; Chaudry, IH; Cioffi, WG; Wichmann, MW, 1997) |
| "The effect of differences in sympathoadrenomedullary and pituitary-adrenocortical responses of individual animals to 35% hemorrhage on severity of shock induction has been studied in unanesthetized unrestrained rats by measuring plasma concentrations of adrenaline (A), noradrenaline (NA), corticosterone (CS) and adrenocorticotropin (ACTH)." | 3.68 | Hormonal responses to hemorrhage and their relationship to individual hemorrhagic shock susceptibility. ( Grässler, J; Jezová, D; Kvetnanský, R; Scheuch, DW, 1990) |
| "Propranolol and clonidine were administered by daily intraperitoneal injection until sacrifice on day seven." | 1.56 | Modulation of the HGF/c-Met Axis Impacts Prolonged Hematopoietic Progenitor Mobilization Following Trauma and Chronic Stress. ( Brakenridge, SC; Efron, PA; Kannan, KB; Loftus, TJ; Mira, JC; Mohr, AM, 2020) |
| "We performed surgical trauma in male rats of three different ages (3-, 6-, and 10-weeks old)." | 1.35 | Age and tissue specific differences in the development of acute insulin resistance following injury. ( Messina, JL; Zhai, L, 2009) |
| "The early stress responses to hemorrhagic shock, trauma and endotoxicosis are associated with an early proinflammatory response characterized by increased gene expression of proinflammatory cytokines, PMN influx and accumulation in the lung and apoptosis." | 1.31 | Noradrenergic inhibition of TNF upregulation in hemorrhagic shock. ( Molina, PE, 2001) |
| "The mice then underwent soft-tissue trauma (laparotomy) and hemorrhagic shock (blood pressure 35+/-5 mm Hg for 90 minutes) followed by adequate fluid resuscitation (shed blood and lactated Ringer's solution) or sham operation." | 1.30 | Testosterone and/or low estradiol: normally required but harmful immunologically for males after trauma-hemorrhage. ( Angele, MK; Ayala, A; Bland, KI; Chaudry, IH; Cioffi, WG; Monfils, BA, 1998) |
| "To study this, soft-tissue trauma (2." | 1.29 | Melatonin administration attenuates depressed immune functions trauma-hemorrhage. ( Ayala, A; Chaudry, IH; Wichmann, MW; Zellweger, R, 1996) |
| "Corticosterone plasma levels were significantly elevated in both trauma-hemorrhage groups compared with those in sham-operated mice." | 1.29 | Mechanism of immunosuppression in males following trauma-hemorrhage. Critical role of testosterone. ( Ayala, A; Chaudry, IH; DeMaso, CM; Wichmann, MW; Zellweger, R, 1996) |
| "The effects of surgical trauma and hemorrhagic shock on the circadian rhythmicity of corticosteroid secretion in the rat were investigated." | 1.26 | Circadian periodicity of plasma corticosterone levels in rats subjected to hemorrhagic shock and surgical trauma. ( Jackson, BT; Levine, RL; Lothrop, DA; McIntosh, TK, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (24.00) | 18.7374 |
| 1990's | 9 (36.00) | 18.2507 |
| 2000's | 6 (24.00) | 29.6817 |
| 2010's | 2 (8.00) | 24.3611 |
| 2020's | 2 (8.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wepler, M | 1 |
| Preuss, JM | 1 |
| Tilp, C | 1 |
| Keck, M | 1 |
| Blender, J | 1 |
| Wachter, U | 1 |
| Merz, T | 1 |
| Vogt, J | 1 |
| Kress, S | 1 |
| Gröger, M | 1 |
| Hoffmann, A | 1 |
| Fink, M | 1 |
| Calzia, E | 1 |
| Burret, U | 1 |
| Radermacher, P | 1 |
| Tuckermann, JP | 1 |
| Vettorazzi, S | 1 |
| Loftus, TJ | 1 |
| Kannan, KB | 1 |
| Mira, JC | 1 |
| Brakenridge, SC | 1 |
| Efron, PA | 1 |
| Mohr, AM | 1 |
| Xia, X | 1 |
| Wang, X | 1 |
| Li, Q | 1 |
| Li, N | 1 |
| Li, J | 1 |
| Wang, H | 1 |
| Guan, Y | 1 |
| Widlund, AL | 1 |
| Becker, LB | 1 |
| Baur, JA | 1 |
| Reilly, PM | 1 |
| Sims, CA | 1 |
| Zhai, L | 1 |
| Messina, JL | 1 |
| Gundersen, Y | 1 |
| Vaagenes, P | 1 |
| Reistad, T | 1 |
| Opstad, PK | 1 |
| Fukuda, T | 1 |
| Nishimoto, C | 1 |
| Miyabe, M | 1 |
| Toyooka, H | 1 |
| Levine, RL | 1 |
| McIntosh, TK | 1 |
| Lothrop, DA | 1 |
| Jackson, BT | 1 |
| Wichmann, MW | 5 |
| Zellweger, R | 4 |
| Ayala, A | 6 |
| Chaudry, IH | 6 |
| DeMaso, CM | 3 |
| Zhu, XH | 1 |
| Angele, MK | 2 |
| Cioffi, WG | 2 |
| Maitra, SR | 1 |
| Gestring, M | 1 |
| el-Maghrabi, MR | 1 |
| Monfils, BA | 1 |
| Bland, KI | 1 |
| Molina, PE | 3 |
| Bagby, GJ | 1 |
| Stahls, P | 1 |
| Eijgelshoven, MH | 1 |
| De Kloet, ER | 1 |
| Van den Berg, DT | 1 |
| Van Giersbergen, PL | 1 |
| Grässler, J | 1 |
| Jezová, D | 1 |
| Kvetnanský, R | 1 |
| Scheuch, DW | 1 |
| Bernardini, R | 1 |
| De Ambrosi, L | 1 |
| Akiyama, M | 1 |
| Shirakawa, T | 1 |
| Hattori, N | 1 |
| Takahashi, K | 1 |
| Azuma, K | 1 |
| Totsuka, M | 1 |
| Hayasaka, H | 1 |
| Schildt, BE | 1 |
| Ryan, NT | 1 |
| George, BC | 1 |
| Odessey, R | 1 |
| Egdahl, RH | 1 |
| Ramazzotto, LJ | 1 |
| Carlin, R | 1 |
| Engstrom, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Critical Illness Stress-induced Immune Suppression Prevention Trial[NCT00395161] | Phase 3 | 293 participants (Actual) | Interventional | 2007-04-30 | Terminated (stopped due to Terminated for futility on 11/30/09 based on the recommendation of the DSMB) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00395161)
Timeframe: 28 days after admission to the PICU
| Intervention | participants (Number) |
|---|---|
| Enteral Zinc, Selenium, Glutamine, and IV Metoclopramide | 15 |
| Enteral Whey Protein, IV Saline | 8 |
(NCT00395161)
Timeframe: 48 hours after admission until PICU discharge
| Intervention | Days (Median) |
|---|---|
| Enteral Zinc, Selenium, Glutamine, and IV Metoclopramide | 1 |
| Enteral Whey Protein, IV Saline | 2 |
What is reported is the number of participants with counts qualifying as lymphopenia. (NCT00395161)
Timeframe: from time of PICU admission till discharge from PICU
| Intervention | participants (Number) |
|---|---|
| Enteral Zinc, Selenium, Glutamine, and IV Metoclopramide | 5 |
| Enteral Whey Protein, IV Saline | 12 |
(NCT00395161)
Timeframe: 48 hours after PICU admission till discharge from PICU
| Intervention | Mean number of events per 100 study days (Mean) |
|---|---|
| Daily Nutriceutical Supplementation | 4.99 |
| Whey Protein | 4.83 |
(NCT00395161)
Timeframe: 48 hours after admission until 5 days after discharged from the PICU
| Intervention | Days (Median) |
|---|---|
| Daily Nutriceutical Supplementation | 12.1 |
| Whey Protein | 13.2 |
1 review available for corticosterone and Hemorrhagic Shock
| Article | Year |
|---|---|
The role of the RES in shock states.
Topics: Adrenocorticotropic Hormone; Animals; Burns; Corticosterone; Depression, Chemical; Dogs; Humans; In | 1971 |
1 trial available for corticosterone and Hemorrhagic Shock
| Article | Year |
|---|---|
Prolactin administration following hemorrhagic shock improves macrophage cytokine release capacity and decreases mortality from subsequent sepsis.
Topics: Animals; Corticosterone; Cytokines; Female; Gene Expression; Interleukin-1; Interleukin-6; Macrophag | 1996 |
23 other studies available for corticosterone and Hemorrhagic Shock
| Article | Year |
|---|---|
Cigarette smoke exposure reduces hemorrhagic shock induced circulatory dysfunction in mice with attenuated glucocorticoid receptor function.
Topics: Animals; Catecholamines; Cigarette Smoking; Corticosterone; Cytokines; Glucocorticoids; Hypoxia; Lac | 2022 |
Modulation of the HGF/c-Met Axis Impacts Prolonged Hematopoietic Progenitor Mobilization Following Trauma and Chronic Stress.
Topics: Animals; Clonidine; Corticosterone; Enzyme-Linked Immunosorbent Assay; Hematopoietic Stem Cells; Hep | 2020 |
Essential amino acid enriched high-protein enteral nutrition modulates insulin-like growth factor-1 system function in a rat model of trauma-hemorrhagic shock.
Topics: Amino Acids, Essential; Animals; Blotting, Western; Corticosterone; Dietary Proteins; Disease Models | 2013 |
Resveratrol ameliorates mitochondrial dysfunction but increases the risk of hypoglycemia following hemorrhagic shock.
Topics: Animals; Blood Glucose; Corticosterone; Glucagon; Glucagon-Like Peptide 1; Hypoglycemia; Insulin; In | 2014 |
Age and tissue specific differences in the development of acute insulin resistance following injury.
Topics: Aging; Animals; Corticosterone; Glucocorticoids; Insulin; Insulin Receptor Substrate Proteins; Insul | 2009 |
Modest protection of early hydrocortisone treatment in a rat model of volume-controlled haemorrhage.
Topics: Animals; Blood Pressure; Cell Hypoxia; Corticosterone; Hydrocortisone; Leukocytes; Liver; Male; Mult | 2003 |
Unilateral adrenalectomy attenuates hemorrhagic shock-induced analgesia in rats.
Topics: Adrenal Glands; Adrenalectomy; Adrenergic alpha-Antagonists; Analgesia; Animals; Blood Gas Analysis; | 2007 |
Circadian periodicity of plasma corticosterone levels in rats subjected to hemorrhagic shock and surgical trauma.
Topics: Animals; Circadian Rhythm; Corticosterone; Male; Rats; Rats, Inbred Strains; Shock, Hemorrhagic; Sho | 1980 |
Melatonin administration attenuates depressed immune functions trauma-hemorrhage.
Topics: Acquired Immunodeficiency Syndrome; Analysis of Variance; Animals; Corticosterone; Humans; Interleuk | 1996 |
Mechanism of immunosuppression in males following trauma-hemorrhage. Critical role of testosterone.
Topics: Androgens; Animals; Blood Pressure; Cell Division; Corticosterone; Disease Susceptibility; Immune To | 1996 |
Enhanced immune responses in females, as opposed to decreased responses in males following haemorrhagic shock and resuscitation.
Topics: Animals; Cell Division; Corticosterone; Female; Lymphokines; Male; Mice; Mice, Inbred C3H; Monokines | 1996 |
Flutamide: a novel agent for restoring the depressed cell-mediated immunity following soft-tissue trauma and hemorrhagic shock.
Topics: Animals; Body Weight; Corticosterone; Flutamide; Immunity, Cellular; Injections, Subcutaneous; Inter | 1997 |
Alterations in hepatic 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and glucose-6-phosphatase gene expression after hemorrhagic hypotension and resuscitation.
Topics: Animals; Blood Glucose; Corticosterone; Gene Expression; Glucagon; Gluconeogenesis; Glucose-6-Phosph | 1997 |
Testosterone and/or low estradiol: normally required but harmful immunologically for males after trauma-hemorrhage.
Topics: Animals; Corticosterone; Dihydrotestosterone; Disease Models, Animal; Estradiol; Female; Injections, | 1998 |
Opiate modulation of hemodynamic, hormonal, and cytokine responses to hemorrhage.
Topics: Adrenocorticotropic Hormone; Animals; Apoptosis; beta-Endorphin; Blood Pressure; Corticosterone; Cyt | 2001 |
Noradrenergic inhibition of TNF upregulation in hemorrhagic shock.
Topics: Animals; Apoptosis; beta-Endorphin; Catecholamines; Corticosterone; Hypotension; Lung; Male; Neuroim | 2001 |
Hemorrhage alters neuroendocrine, hemodynamic, and compartment-specific TNF responses to LPS.
Topics: Animals; Corticosterone; Epinephrine; Hemodynamics; Inflammation; Lipopolysaccharides; Macrophages, | 2001 |
Activation of glucocorticoid receptors and the effect of naloxone during hemorrhagic hypotension.
Topics: Adrenalectomy; Animals; Corticosterone; Drug Interactions; Hemodynamics; Male; Mifepristone; Naloxon | 1991 |
Hormonal responses to hemorrhage and their relationship to individual hemorrhagic shock susceptibility.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Blood Pressure; Blood Volume; Corticosterone; | 1990 |
Pharmacodynamic properties of adrenal cortical extracts in comparison to synthetic corticosteroid mixture in the rat.
Topics: Adrenal Cortex; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Animals; Circadian Rhythm; Cor | 1985 |
[Adrenal circulation of rabbits in hemorrhagic and endotoxin shock].
Topics: Adrenal Glands; Animals; Blood Pressure; Corticosterone; Electrolytes; Hydrogen-Ion Concentration; L | 1987 |
Effect of hemorrhagic shock, fasting, and corticosterone administration on leucine oxidation and incorporation into protein by skeletal muscle.
Topics: Animals; Carbon Dioxide; Carbon Radioisotopes; Corticosterone; Depression, Chemical; Fasting; Female | 1974 |
Serum acid phosphatase activity during hemorrhagic shock.
Topics: Acid Phosphatase; Animals; Corticosterone; Dimethyl Sulfoxide; Estradiol; Female; Male; Prednisone; | 1973 |