Page last updated: 2024-11-06

corticosterone and Epilepsy

corticosterone has been researched along with Epilepsy in 34 studies

Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)

Research Excerpts

ExcerptRelevanceReference
"Ferulic acid treatment, on the other hand, significantly decreased seizure susceptibility and depression like behavior, possibly because of increased progesterone, restored estradiol, corticosterone, monoamines, and GAD enzyme activity."5.72Ferulic acid inhibits catamenial epilepsy through modulation of female hormones. ( Dhillon, HK; Goel, RK; Singh, T, 2022)
"Baicalein was injected intraperitoneally to TLE rats for two weeks after the onset of spontaneous recurrent seizures (SRS)."5.51Baicalein improves cognitive deficits and hippocampus impairments in temporal lobe epilepsy rats. ( Ding, JQ; Li, W; Qian, X; Wang, ZR; Zhang, M; Zhang, TY; Zheng, JJ; Zhong, JG, 2019)
" Epilepsy-associated comorbid depression was evaluated by tail suspension test, sucrose preference test, and plasma corticosterone levels, whereas epilepsy-associated memory deficit condition was assessed by step-through paradigm, Morris water maze, and nitrite levels."3.96Exploring the ameliorative role of α7 neuronal nicotinic acetylcholine receptor modulation in epilepsy and associated comorbidities in post-PTZ-kindled mice. ( Goel, RK; Kaur, S; Sharma, NK, 2020)
"We have previously demonstrated that low-dose corticosterone (CS) administration, used as a model of the effect of chronic stress, accelerates epileptogenesis in the electrical amygdala kindling rat model of temporal lobe epilepsy (TLE)."3.74The acceleration of amygdala kindling epileptogenesis by chronic low-dose corticosterone involves both mineralocorticoid and glucocorticoid receptors. ( Couper, A; Jones, NC; Kumar, G; Morris, MJ; O'Brien, TJ; Rees, SM; Salzberg, MR, 2007)
"Ferulic acid treatment, on the other hand, significantly decreased seizure susceptibility and depression like behavior, possibly because of increased progesterone, restored estradiol, corticosterone, monoamines, and GAD enzyme activity."1.72Ferulic acid inhibits catamenial epilepsy through modulation of female hormones. ( Dhillon, HK; Goel, RK; Singh, T, 2022)
"Baicalein was injected intraperitoneally to TLE rats for two weeks after the onset of spontaneous recurrent seizures (SRS)."1.51Baicalein improves cognitive deficits and hippocampus impairments in temporal lobe epilepsy rats. ( Ding, JQ; Li, W; Qian, X; Wang, ZR; Zhang, M; Zhang, TY; Zheng, JJ; Zhong, JG, 2019)
"Depression was evaluated in all experimental groups using tail suspension and forced swim test on days 1, 5, 10 and 15, 2h after pentylenetetrazole challenge."1.43Adjuvant indoleamine 2,3-dioxygenase enzyme inhibition for comprehensive management of epilepsy and comorbid depression. ( Goel, RK; Singh, T, 2016)
"Epilepsy is a heterogeneous and chronic neurological condition of undefined etiology in the majority of cases."1.39Prenatal transport stress, postnatal maternal behavior, and offspring sex differentially affect seizure susceptibility in young rats. ( Currie, RW; Esser, MJ; Galic, MA; Moriyama, C; Mychasiuk, R; Perrot, TS; Pittman, QJ, 2013)
"Kindled epilepsy was induced at 3 different ZTs, and sleep-wake activities were analyzed before and after full-blown seizure."1.38Occurrence of epilepsy at different zeitgeber times alters sleep homeostasis differently in rats. ( Chang, FC; Chen, YJ; Lin, CT; Yi, PL, 2012)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19903 (8.82)18.7374
1990's7 (20.59)18.2507
2000's3 (8.82)29.6817
2010's14 (41.18)24.3611
2020's7 (20.59)2.80

Authors

AuthorsStudies
Buchecker, V1
Koska, I1
Pace, C1
Talbot, SR1
Palme, R1
Bleich, A1
Potschka, H1
Ryan-Coats, SK1
Hughes, SD1
Holz, FM1
Kreger, RB1
Koulibali, CI1
Khan, HA1
Harris, KC1
Kelly, AE1
Epps, SA1
Rupasinghe, R1
Dezsi, G1
Ozturk, E1
Carron, S1
Hudson, MR1
Casillas-Espinosa, PM1
Jones, NC4
Dhillon, HK1
Singh, T2
Goel, RK3
Zub, E1
Canet, G1
Garbelli, R1
Blaquiere, M1
Rossini, L1
Pastori, C1
Sheikh, M1
Reutelingsperger, C1
Klement, W1
de Bock, F1
Audinat, E1
Givalois, L1
Solito, E1
Marchi, N1
Sharma, NK1
Kaur, S1
Basu, T1
Maguire, J1
Salpekar, JA1
Godoy, LD1
Garcia-Cairasco, N1
Qian, X1
Wang, ZR1
Zheng, JJ1
Ding, JQ1
Zhong, JG1
Zhang, TY1
Li, W1
Zhang, M1
Moriyama, C1
Galic, MA1
Mychasiuk, R1
Pittman, QJ1
Perrot, TS1
Currie, RW1
Esser, MJ1
Ngoupaye, GT1
Bum, EN1
Daniels, WM1
Koe, AS1
Salzberg, MR3
Morris, MJ3
O'Brien, TJ3
Barbier, L1
Canini, F1
Giroud, C1
Beaup, C1
Foquin, A1
Maury, R1
Denis, J1
Peinnequin, A1
Dorandeu, F1
Borekci, B1
Ingec, M1
Yilmaz, M1
Kukula, O1
Karaca, M1
Hacimuftuoglu, A1
Halici, Z1
Suleyman, H1
Sadaghiani, MM1
Saboory, E1
Sawyer, NT1
Escayg, A1
Tolmacheva, EA1
Oitzl, MS1
van Luijtelaar, G1
Lee, HE1
Yang, M1
Rees, SM2
Desgent, S1
Duss, S1
Sanon, NT1
Lema, P1
Lévesque, M1
Hébert, D1
Rébillard, RM1
Bibeau, K1
Brochu, M1
Carmant, L1
Yi, PL1
Chen, YJ1
Lin, CT1
Chang, FC1
Kumar, G1
Couper, A1
Rangon, CM1
Fortes, S1
Lelièvre, V1
Leroux, P1
Plaisant, F1
Joubert, C1
Lanfumey, L1
Cohen-Salmon, C1
Gressens, P1
Capasso, A2
Sorrentino, L2
Di Giannuario, A2
Palazzesi, S2
Pieretti, S2
Loizzo, A2
Cutrufo, C1
Talmi, M1
Carlier, E1
Bengelloun, W1
Soumireu-Mourat, B1
Krugers, HJ2
Kemper, RH1
Korf, J2
Ter Horst, GJ1
Knollema, S1
Karst, H1
de Kloet, ER1
Joëls, M2
Maslam, S1
Van Vuuren, SM1
Pavlides, C1
Nivón, LG1
McEwen, BS1
Bowers, BJ1
Bosy, TZ1
Wehner, JM1
Murphy, BE1
Cosgrove, JB1
McIlquham, MC1
Pattee, CJ1
Yamashita, I1
Moroji, T1
Yamazaki, K1
Kato, H1
Sakashita, A1
Bennett, R1
Hughes, GR1
Bywaters, EG1
Holt, PJ1

Reviews

1 review available for corticosterone and Epilepsy

ArticleYear
Hypothalamic-pituitary-adrenal axis targets for the treatment of epilepsy.
    Neuroscience letters, 2021, 02-16, Volume: 746

    Topics: Adrenocorticotropic Hormone; Animals; Anticonvulsants; Corticosterone; Desoxycorticosterone; Epileps

2021

Other Studies

33 other studies available for corticosterone and Epilepsy

ArticleYear
Toward Evidence-Based Severity Assessment in Mouse Models with Repeated Seizures: (II.) Impact of Surgery and Intrahippocampal Kainate.
    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 2023, Volume: 64, Issue:1

    Topics: Animals; Corticosterone; Disease Models, Animal; Epilepsy; Kainic Acid; Mice; Seizures; Status Epile

2023
Something new and something blue: Responses to novelty in a rodent model of depression and epilepsy comorbidity.
    Physiology & behavior, 2022, 05-15, Volume: 249

    Topics: Animals; Anxiety; Comorbidity; Corticosterone; Depression; Disease Models, Animal; Epilepsy; Humans;

2022
Early life adversity accelerates epileptogenesis and enhances depression-like behaviors in rats.
    Experimental neurology, 2022, Volume: 354

    Topics: Adverse Childhood Experiences; Animals; Corticosterone; Depression; Disease Models, Animal; Epilepsy

2022
Ferulic acid inhibits catamenial epilepsy through modulation of female hormones.
    Metabolic brain disease, 2022, Volume: 37, Issue:8

    Topics: Adult; Animals; Corticosterone; Epilepsy; Estradiol; Female; Finasteride; Horses; Humans; Mice; Neur

2022
The GR-ANXA1 pathway is a pathological player and a candidate target in epilepsy.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:12

    Topics: Animals; Annexin A1; Blood Cell Count; Brain; Corticosterone; Epilepsy; Gene Expression Regulation;

2019
Exploring the ameliorative role of α7 neuronal nicotinic acetylcholine receptor modulation in epilepsy and associated comorbidities in post-PTZ-kindled mice.
    Epilepsy & behavior : E&B, 2020, Volume: 103, Issue:Pt A

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anticonvulsants; Corticosterone; Depression; Dose-

2020
Maternal behavior and the neonatal HPA axis in the Wistar Audiogenic Rat (WAR) strain: Early-life implications for a genetic animal model in epilepsy.
    Epilepsy & behavior : E&B, 2021, Volume: 117

    Topics: Animals; Behavior, Animal; Corticosterone; Epilepsy; Female; Humans; Hypothalamo-Hypophyseal System;

2021
Baicalein improves cognitive deficits and hippocampus impairments in temporal lobe epilepsy rats.
    Brain research, 2019, 07-01, Volume: 1714

    Topics: Animals; Brain; Cofilin 1; Cognition; Cognition Disorders; Cognitive Dysfunction; Corticosterone; Di

2019
Prenatal transport stress, postnatal maternal behavior, and offspring sex differentially affect seizure susceptibility in young rats.
    Epilepsy & behavior : E&B, 2013, Volume: 29, Issue:1

    Topics: Animals; Animals, Newborn; Brain; Corticosterone; Disease Models, Animal; Disease Susceptibility; Ep

2013
Antidepressant-like effects of the aqueous macerate of the bulb of Gladiolus dalenii Van Geel (Iridaceae) in a rat model of epilepsy-associated depression.
    BMC complementary and alternative medicine, 2013, Oct-20, Volume: 13

    Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Epile

2013
Early life maternal separation stress augmentation of limbic epileptogenesis: the role of corticosterone and HPA axis programming.
    Psychoneuroendocrinology, 2014, Volume: 42

    Topics: Animals; Corticosterone; Epilepsy; Female; Hypothalamo-Hypophyseal System; Kindling, Neurologic; Lif

2014
Beneficial effects of a ketamine/atropine combination in soman-poisoned rats under a neutral thermal environment.
    Neurotoxicology, 2015, Volume: 50

    Topics: Animals; Anticonvulsants; Atropine; Body Temperature; Brain; Brain Injuries; Chemical Warfare Agents

2015
Adjuvant indoleamine 2,3-dioxygenase enzyme inhibition for comprehensive management of epilepsy and comorbid depression.
    European journal of pharmacology, 2016, Aug-05, Volume: 784

    Topics: Animals; Comorbidity; Corticosterone; Depression; Drug Interactions; Enzyme Inhibitors; Epilepsy; Hi

2016
Effects of female sex hormones on caffeine-induced epileptiform activity in rats.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2010, Volume: 26, Issue:5

    Topics: Animals; Caffeine; Corticosterone; Epilepsy; Epinephrine; Estrogen Antagonists; Estrogens; Female; F

2010
Prenatal stress potentiates pilocarpine-induced epileptic behaviors in infant rats both time and sex dependently.
    Epilepsy & behavior : E&B, 2010, Volume: 18, Issue:3

    Topics: Analysis of Variance; Animals; Animals, Newborn; Corticosterone; Disease Models, Animal; Epilepsy; F

2010
Stress and epilepsy: multiple models, multiple outcomes.
    Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society, 2010, Volume: 27, Issue:6

    Topics: Adrenocorticotropic Hormone; Animals; Brain; Corticosterone; Corticotropin-Releasing Hormone; Diseas

2010
Stress, glucocorticoids and absences in a genetic epilepsy model.
    Hormones and behavior, 2012, Volume: 61, Issue:5

    Topics: Animals; Circadian Rhythm; Corticosterone; Disease Models, Animal; Electric Stimulation; Electroence

2012
Repeatedly stressed rats have enhanced vulnerability to amygdala kindling epileptogenesis.
    Psychoneuroendocrinology, 2013, Volume: 38, Issue:2

    Topics: Amygdala; Animals; Corticosterone; Disease Models, Animal; Electric Stimulation; Epilepsy; Female; H

2013
Early-life stress is associated with gender-based vulnerability to epileptogenesis in rat pups.
    PloS one, 2012, Volume: 7, Issue:8

    Topics: Androgens; Animals; Animals, Newborn; Behavior, Animal; Benzoxazines; Cerebral Cortex; Corticosteron

2012
Occurrence of epilepsy at different zeitgeber times alters sleep homeostasis differently in rats.
    Sleep, 2012, Dec-01, Volume: 35, Issue:12

    Topics: Amygdala; Animals; Circadian Rhythm; Corticosterone; Epilepsy; Interleukin-1; Kindling, Neurologic;

2012
The acceleration of amygdala kindling epileptogenesis by chronic low-dose corticosterone involves both mineralocorticoid and glucocorticoid receptors.
    Psychoneuroendocrinology, 2007, Volume: 32, Issue:7

    Topics: Adrenal Glands; Amygdala; Animals; Brain; Corticosterone; Data Interpretation, Statistical; Dose-Res

2007
Chronic mild stress during gestation worsens neonatal brain lesions in mice.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, Jul-11, Volume: 27, Issue:28

    Topics: Animals; Animals, Newborn; Brain; Brain Diseases; Chronic Disease; Corticosterone; Epilepsy; Female;

2007
Dexamethasone and hormones related to the hypothalamic-pituitary-adrenal axis modulate inherited neocortical spindling in DBA/2J mice.
    Neuropsychobiology, 1994, Volume: 29, Issue:3

    Topics: Adrenocorticotropic Hormone; Animals; Cerebral Cortex; Cortical Synchronization; Corticosterone; Cor

1994
Opioids and corticosteroids involvement in the regulation of the neocortical spindling episodes in DBA/2J mice.
    Annali dell'Istituto superiore di sanita, 1993, Volume: 29, Issue:3

    Topics: Adrenal Cortex; Animals; Cerebral Cortex; Corticosterone; Cycloheximide; Dexamethasone; Disease Mode

1993
Synergistic action of corticosterone on kainic acid-induced electrophysiological alterations in the hippocampus.
    Brain research, 1995, Dec-15, Volume: 704, Issue:1

    Topics: Animals; Corticosterone; Drug Synergism; Epilepsy; Evoked Potentials; Hippocampus; In Vitro Techniqu

1995
Metyrapone reduces rat brain damage and seizures after hypoxia-ischemia: an effect independent of modulation of plasma corticosterone levels?
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1998, Volume: 18, Issue:4

    Topics: Animals; Blood Glucose; Body Temperature; Brain Damage, Chronic; Brain Ischemia; Corticosterone; Epi

1998
Episodic corticosterone treatment accelerates kindling epileptogenesis and triggers long-term changes in hippocampal CA1 cells, in the fully kindled state.
    The European journal of neuroscience, 1999, Volume: 11, Issue:3

    Topics: Action Potentials; Animals; Anti-Inflammatory Agents; Calcium; Corticosterone; Epilepsy; Excitatory

1999
Postischemic steroid modulation: effects on hippocampal neuronal integrity and synaptic plasticity.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1999, Volume: 19, Issue:10

    Topics: Action Potentials; Animals; Brain Ischemia; Corticosterone; Dexamethasone; Electrophysiology; Epilep

1999
Effects of chronic stress on hippocampal long-term potentiation.
    Hippocampus, 2002, Volume: 12, Issue:2

    Topics: Animals; Chronic Disease; Corticosterone; Epilepsy; Long-Term Potentiation; Male; Mossy Fibers, Hipp

2002
Adrenalectomy increases bicuculline-induced seizure sensitivity in long-sleep and short-sleep mice.
    Pharmacology, biochemistry, and behavior, 1991, Volume: 38, Issue:3

    Topics: Adrenal Glands; Adrenalectomy; Animals; Bicuculline; Body Weight; Corticosterone; Epilepsy; Ethanol;

1991
Adrenal corticoid levels in human cerebrospinal fluid.
    Canadian Medical Association journal, 1967, Jul-01, Volume: 97, Issue:1

    Topics: Adrenocorticotropic Hormone; Brain Neoplasms; Cardiovascular Diseases; Corticosterone; Diethylstilbe

1967
Neuroendocrinological studies in mental disorders and psychotropic drugs. I. On the circadian rhythm of the plasma adrenocortical hormone in mental patients and methamphetamine- and chlorpromazine-treated animals.
    Folia psychiatrica et neurologica japonica, 1969, Volume: 23, Issue:2

    Topics: 17-Hydroxycorticosteroids; Adrenocorticotropic Hormone; Adult; Animals; Chlorpromazine; Circadian Rh

1969
Neuropsychiatric problems in systemic lupus erythematosus.
    British medical journal, 1972, Nov-11, Volume: 4, Issue:5836

    Topics: Adolescent; Adult; Cognition Disorders; Corticosterone; Cranial Nerves; Depression; Epilepsy; Female

1972