corticosterone has been researched along with Diseases of Immune System in 6 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pecaut, MJ | 1 |
| Mao, XW | 1 |
| Bellinger, DL | 1 |
| Jonscher, KR | 1 |
| Stodieck, LS | 1 |
| Ferguson, VL | 1 |
| Bateman, TA | 1 |
| Mohney, RP | 1 |
| Gridley, DS | 1 |
| Zhang, Y | 1 |
| Guan, Z | 1 |
| Reader, B | 1 |
| Shawler, T | 1 |
| Mandrekar-Colucci, S | 1 |
| Huang, K | 1 |
| Weil, Z | 1 |
| Bratasz, A | 1 |
| Wells, J | 1 |
| Powell, ND | 1 |
| Sheridan, JF | 1 |
| Whitacre, CC | 1 |
| Rabchevsky, AG | 1 |
| Nash, MS | 1 |
| Popovich, PG | 1 |
| Hodyl, NA | 1 |
| Krivanek, KM | 1 |
| Clifton, VL | 1 |
| Hodgson, DM | 1 |
| Harbuz, MS | 1 |
| Chover-Gonzalez, AJ | 1 |
| Jessop, DS | 1 |
| Romero, E | 1 |
| Guaza, C | 1 |
| Castellano, B | 1 |
| Borrell, J | 1 |
| Fowles, JR | 1 |
| Fairbrother, A | 1 |
| Baecher-Steppan, L | 1 |
| Kerkvliet, NI | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Controlled Trial of Adjunctive Siltuximab in Schizophrenia[NCT02796859] | Phase 1/Phase 2 | 30 participants (Anticipated) | Interventional | 2016-05-31 | Recruiting | ||
| An Open-Label Trial of Tocilizumab in Schizophrenia[NCT01696929] | Phase 1 | 8 participants (Actual) | Interventional | 2012-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The Brief Assessment of Cognition in Schizophrenia (BACS) is the metric used to characterize cognition in this study. The BACS consists of 6 subscales: Verbal Memory (range 0-75), Working Memory (range 0-28), Motor Speed (range 0-100), Verbal Fluency (measure is total number of words generated in two 60 second trials), Attention and Processing speed (range 0-110), and Executive Function (range 0-22). For each subscale, higher scores reflect better cognition. For each subscale, a Standard Deviation Score was calculated based on normative data (Keefe et al. Norms and standardization of the Brief Assessment of Cognition in Schizophrenia (BACS). Schizophrenia Research 102 (2008) 108-115). The BACS composite score is calculated as the average Standard Deviation Score of the 6 subscale scores. The change in BACS composite score was calculated as the BACS composite score at 8 weeks minus the BACS composite score at baseline. (NCT01696929)
Timeframe: Change in BACS composite score from baseline to 8 weeks
| Intervention | Change in BACS Composite Score (Mean) |
|---|---|
| Tocilizumab | 0.7 |
The Positive and Negative Symptoms Scale (PANSS) is the metric used to characterize psychotic symptoms in this study. The PANSS consists of 30 items, each scored 1-7. The range for the PANSS total score is 30-210. There are 3 subscales - PANSS positive score (range 7-49), PANSS negative score (range 7-49), and PANSS general score (range 16-112). PANSS total score is the summation of these 3 subscales. Higher values for the total and subscale scores reflect more severe psychopathology. A positive change in PANSS total score reflects an increase in psychopathology. A negative change in PANSS total score reflects a decrease in psychopathology. (NCT01696929)
Timeframe: Change in PANSS total score from baseline to 8 weeks
| Intervention | Change in PANSS Total Score (Mean) |
|---|---|
| Tocilizumab | -2.6 |
1 review available for corticosterone and Diseases of Immune System
| Article | Year |
|---|---|
Hypothalamo-pituitary-adrenal axis and chronic immune activation.
Topics: Animals; Autoimmune Diseases; Corticosterone; Disease Models, Animal; Humans; Hypothalamo-Hypophysea | 2003 |
5 other studies available for corticosterone and Diseases of Immune System
| Article | Year |
|---|---|
Is spaceflight-induced immune dysfunction linked to systemic changes in metabolism?
Topics: Adrenal Glands; Animals; Catecholamines; Cell Survival; Corticosterone; Female; Gene Expression Prof | 2017 |
Autonomic dysreflexia causes chronic immune suppression after spinal cord injury.
Topics: Adrenergic beta-2 Receptor Antagonists; Animals; Antigens, CD; Autonomic Dysreflexia; Blood Pressure | 2013 |
Innate immune dysfunction in the neonatal rat following prenatal endotoxin exposure.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Blood Cell Count; Corticosterone; Endo | 2008 |
Ontogeny of sensorimotor gating and immune impairment induced by prenatal immune challenge in rats: implications for the etiopathology of schizophrenia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acoustic Stimulation; Age Factors; Analysis of Variance; Animals; An | 2010 |
Ontogeny of sensorimotor gating and immune impairment induced by prenatal immune challenge in rats: implications for the etiopathology of schizophrenia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acoustic Stimulation; Age Factors; Analysis of Variance; Animals; An | 2010 |
Ontogeny of sensorimotor gating and immune impairment induced by prenatal immune challenge in rats: implications for the etiopathology of schizophrenia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acoustic Stimulation; Age Factors; Analysis of Variance; Animals; An | 2010 |
Ontogeny of sensorimotor gating and immune impairment induced by prenatal immune challenge in rats: implications for the etiopathology of schizophrenia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acoustic Stimulation; Age Factors; Analysis of Variance; Animals; An | 2010 |
Immunologic and endocrine effects of the flame-retardant pentabromodiphenyl ether (DE-71) in C57BL/6J mice.
Topics: Animals; Corticosterone; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Endocrine Glands; | 1994 |