Page last updated: 2024-11-06

corticosterone and Depression

corticosterone has been researched along with Depression in 863 studies

Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.

Research Excerpts

ExcerptRelevanceReference
" In this study we have evaluated the MMP-9 activity and protein expression in brain areas relevant to depression using the chronic corticosterone mouse model of depression."8.31Brain matrix metalloproteinase-9 activity is altered in the corticosterone mouse model of depression. ( Breviario, S; Castro, E; Díaz, Á; Florensa-Zanuy, E; Garro-Martínez, E; Pazos, Á; Pilar-Cuéllar, F; Senserrich, J, 2023)
"Here, we employed mouse models of depression induced by chronic unpredictable stress exposure or corticosterone (CORT) stimulation."8.31MAD2B Blunts Chronic Unpredictable Stress and Corticosterone Stimulation-Induced Depression-Like Behaviors in Mice. ( Meng, X; Miao, C; Su, Y; Wang, XL; Zhang, C, 2023)
" Pups whose dams consumed the HFS diet during gestation and lactation exhibited increased depression-related behavior and baseline serum corticosterone levels, but no difference in peak levels in response to stress."8.31Comparison of maternal versus postweaning ingestion of a high fat, high sucrose diet on depression-related behavior, novelty reactivity, and corticosterone levels in young, adult rat offspring. ( Farber, C; Koh, GY; Lane, MA; McKenzie, A; Muraida, JD; Renteria, K; Ritter, J; Rivers, C; Zhu, J, 2023)
"Mirtazapine (MIRT) is a multi-target antidepressant used in treatment of severe depression with promising efficacy, but also with important side effects, mainly sedation and weight gain."8.12Lipoic acid prevents mirtazapine-induced weight gain in mice without impairs its antidepressant-like action in a neuroendocrine model of depression. ( Chaves Filho, AJM; Cunha, NL; De Oliveira, GMF; Gadelha Filho, CVJ; Jucá, PM; Macedo, DS; Oliveira, TQ; Soares, MVR; Vasconcelos, SMM; Viana, GA; Vieira, CFX, 2022)
"Selective serotonergic reuptake inhibitors, including fluoxetine (FLX), are the most commonly used for the treatment of major depression."8.12Galanin (1-15) Enhances the Behavioral Effects of Fluoxetine in the Olfactory Bulbectomy Rat, Suggesting a New Augmentation Strategy in Depression. ( Cantero-García, N; Díaz-Cabiale, Z; Flores-Burgess, A; Fuxe, K; Gago, B; García-Durán, L; Millón, C; Narváez, JA; Puigcerver, A; Santín, L, 2022)
" Changes of serotonin (5-HT), dopamine (DA), norepinephrine (NE), serum corticosterone (CORT), adrenocorticotropic hormone (ACTH), organ index, and histopathology in brain tissue, to explore the treatment and characteristics of total white glucosides in depression model, were prepared by different stimuli in 21 days."8.12Pharmacological Study on Total Glycosides of Xiebai Protecting against Depression Model. ( Jiang, M; Miao, M; Zhao, H, 2022)
"The aim of this study was to investigate the antidepressant effect of Jujuboside A (JuA) on corticosterone (CORT)-induced depression in mice and explore the underlying mechanisms."8.12Antidepressant effect of Jujuboside A on corticosterone-induced depression in mice. ( Gong, J; Li, H; Li, J; Xie, X; Zhang, T, 2022)
"Sustained elevation of corticosterone (CORT) is one of the common causes of aging and major depression disorder."8.02Low corticosterone levels attenuate late life depression and enhance glutamatergic neurotransmission in female rats. ( Chen, NH; Chu, SF; Cui, LY; He, HY; He, WB; Wang, ZZ; Yang, B; Zhang, Z; Zhou, X, 2021)
" Thus, the effects of naringenin, a potent antioxidant, anti-inflammatory and neuroprotective bioflavonoid on hypoxic stress-induced depressive-like and anxiety-related behaviors in mice, and the underlying molecular mechanisms were evaluated in this study."8.02Naringenin improves depressive- and anxiety-like behaviors in mice exposed to repeated hypoxic stress through modulation of oxido-inflammatory mediators and NF-kB/BDNF expressions. ( Ajayi, AM; Bakre, AG; Ben-Azu, B; Femi-Akinlosotu, O; Olugbemide, AS; Umukoro, S, 2021)
"Metformin attenuated the depression-like behaviors induced by CORT."8.02Metformin Attenuates the Metabolic Disturbance and Depression-like Behaviors Induced by Corticosterone and Mediates the Glucose Metabolism Pathway. ( Guan, Y; Guo, Y; Hao, Y; Huang, X; Lang, X; Li, Z; Tong, Y; Xie, X, 2021)
" The treatments with ketamine, guanosine, and ketamine plus guanosine were effective to counteract corticosterone-induced anxiety-like phenotype, but not disturbances in the hippocampal NLRP3 pathway."8.02Low doses of ketamine and guanosine abrogate corticosterone-induced anxiety-related behavior, but not disturbances in the hippocampal NLRP3 inflammasome pathway. ( Camargo, A; Dalmagro, AP; Fraga, DB; Kaster, MP; Rodrigues, ALS; Rosa, JM; Zeni, ALB, 2021)
"The present study aimed to evaluate the potential role of ANXA1 and its main receptor, as a cellular mediator of behavioural disorders, in a model of Corticosterone (CORT)-induced depression and subsequently, the possible correlation between the depressive state and impairment of hippocampal memory."7.96The Role of Annexin A1 and Formyl Peptide Receptor 2/3 Signaling in Chronic Corticosterone-Induced Depression-Like behaviors and Impairment in Hippocampal-Dependent Memory. ( Cordaro, M; Crupi, R; Cuzzocrea, S; D'amico, R; Di Paola, R; Fusco, R; Gugliandolo, E; Impellizzeri, D; Peritore, AF; Scuto, M; Siracusa, R, 2020)
" Here we aimed to compare the effects of (R)-norketamine ((R)-NK), (S)-NK, (2R,6R)-HNK, and (2S,6S)-HNK in a mouse model of depression induced by chronic corticosterone (CORT) injection."7.96(S)-norketamine and (2S,6S)-hydroxynorketamine exert potent antidepressant-like effects in a chronic corticosterone-induced mouse model of depression. ( Ago, Y; Chen, L; Hashimoto, H; Hashimoto, K; Higuchi, M; Kasai, A; Naito, M; Nakagawa, S; Nakazawa, T; Seiriki, K; Tanabe, W; Tsukada, S; Yamaguchi, T; Yokoyama, R, 2020)
"As a continuation of our previous experiments, this study aimed to investigate the antidepressant- and anxiolytic-like activity of pitolisant in mice using the corticosterone-induced depression model."7.96Pitolisant protects mice chronically treated with corticosterone from some behavioral but not metabolic changes in corticosterone-induced depression model. ( Kieć-Kononowicz, K; Kotańska, M; Mika, K; Pytka, K; Sapa, J; Sałaciak, K; Wheeler, L, 2020)
" Considering that ketamine has significant knock-on effects, this study investigated the effects of a single coadministration with subthreshold doses of ketamine plus guanosine in a corticosterone (CORT)-induced animal model of depression and the role of anti-inflammatory and antioxidant pathways."7.96Subthreshold doses of guanosine plus ketamine elicit antidepressant-like effect in a mouse model of depression induced by corticosterone: Role of GR/NF-κB/IDO-1 signaling. ( B Zeni, AL; Camargo, A; Dalmagro, AP; M Rosa, J; P Kaster, M; S Rodrigues, AL; Tasca, CI, 2020)
"This study assessed the effect of swimming training on anxiety-like behaviors and corticosterone."7.96The Effect of Swimming on Anxiety-Like Behaviors and Corticosterone in Stressed and Unstressed Rats. ( Aligholi, H; Brand, S; Koushkie Jahromi, M; Rezaei, R; Safari, MA, 2020)
"A total of 36 rats were randomly assigned to three groups: a normal group, model group (depression), and treatment group (depression + gentiopicroside)."7.91Metabolomic evidence for the therapeutic effect of gentiopicroside in a corticosterone-induced model of depression. ( Cui, Q; Liu, Z; Wang, C; Wang, G; Yao, T; Zhang, Q, 2019)
"To discover and assess the differentially expressed proteins (DEPs) of hippocampus after oral administration of XCHT in corticosterone (CORT) induced model of depression by using isobaric tags for relative and absolute quantification (iTRAQ) analysis."7.91Quantitative proteomics reveal antidepressant potential protein targets of xiaochaihutang in corticosterone induced model of depression. ( He, M; Li, Y; Pan, X; Su, D; Wu, C; Yang, J; Zhang, H; Zhang, K, 2019)
" A treatment with escitalopram reversed depression-like behavior accompanied by reductions in BDNF levels in serum and the nucleus accumbens, while a treatment with blonanserin ameliorated abnormal social interaction behavior with reductions in serum BDNF levels."7.91Antidepressant activities of escitalopram and blonanserin on prenatal and adolescent combined stress-induced depression model: Possible role of neurotrophic mechanism change in serum and nucleus accumbens. ( Deriha, K; Furuse, K; Hashiguchi, H; Hashimoto, E; Ishii, T; Kawanishi, C; Kigawa, Y; Shiraishi, M; Tayama, M; Ukai, W, 2019)
" This study utilized a translational animal model of maternal depression (based on giving high levels of corticosterone (CORT, 40 mg/kg, s."7.91Developmental outcomes after gestational antidepressant treatment with sertraline and its discontinuation in an animal model of maternal depression. ( Brummelte, S; Kott, JM; Mooney-Leber, SM, 2019)
"Our previous finding demonstrated that chronic corticosterone (CORT) may be involved in mediating the pathophysiology of premature aging in rats."7.91Exposure to jet lag aggravates depression-like behaviors and age-related phenotypes in rats subject to chronic corticosterone. ( Fu, Z; Ni, Y; Shen, Q; Wang, X; Wu, J; Xiao, Q; Xie, X; Yu, C; Zhou, J, 2019)
" In this study, we examined the molecular effects associated with a response to a week-long treatment with escitalopram in the chronic escape deficit (CED) model, a validated model of depression based on the induction of an escape deficit after exposure of rats to an unavoidable stress."7.88Molecular changes associated with escitalopram response in a stress-based model of depression. ( Alboni, S; Benatti, C; Blom, JMC; Brunello, N; Mendlewicz, J; Tascedda, F, 2018)
"Many models, such as chronic mild stress, chronic stress or chronic corticosterone injections are used to induce depression associated with cognitive deficits."7.88Combined corticosterone treatment and chronic restraint stress lead to depression associated with early cognitive deficits in mice. ( Bahane, DAN; Bum, EN; Ngoupaye, GT; Yassi, FB, 2018)
" Magnolol, main constituent identified in the barks of Magnolia officinalis, exerted antidepressant effects in a rat model of depression induced by chronic unpredictable mild stress in previous studies."7.88Antidepressant effects of magnolol in a mouse model of depression induced by chronic corticosterone injection. ( Bai, Y; Dai, G; Jing, W; Ju, W; Song, L; Xu, M; Zhang, W; Zhu, L, 2018)
" Therefore, we tested this hypothesis in the depression model of chronic administration of corticosterone (CORT) in mice and treated the animals daily with liraglutide (5 or 20 nmol/kg ip."7.88Liraglutide attenuates the depressive- and anxiety-like behaviour in the corticosterone induced depression model via improving hippocampal neural plasticity. ( Birong, L; Christian, H; Feiyu, S; Le, W; Weina, H; Yuhu, N, 2018)
" The corticosterone rat model was developed to understand the influence of stress on depression-like symptomatology."7.88Depression-like behaviors induced by chronic corticosterone exposure via drinking water: Time-course analysis. ( Cui, SY; Cui, XY; Ding, H; Hu, X; Liu, YT; Ye, H; Zhang, YH; Zhao, HL, 2018)
"To further explore the underlying antidepressant mechanism of ginseng total saponins (GTS), this study observed the effects on hippocampal astrocyte structural plasticity and hippocampal volume in the corticosterone-induced mouse depression model."7.85Preventive Effects of Ginseng Total Saponins on Chronic Corticosterone-Induced Impairment in Astrocyte Structural Plasticity and Hippocampal Atrophy. ( Chen, L; Dai, JG; Huang, YF; Lin, ZX; Wang, X; Zhao, YN, 2017)
"Corticosterone (CORT) treatment has been evidenced to develop a depression-like state in animals, that mimic hypothalamic-pituitary-adrenal (HPA)-axis dysregulation implicated in the development of depression."7.85Ferulic acid reverses depression-like behavior and oxidative stress induced by chronic corticosterone treatment in mice. ( Camargo, A; Dalmagro, AP; Zeni, ALB, 2017)
"Previously published reports have revealed the antidepressant-like effects of icariin in a chronic mild stress model of depression and in a social defeat stress model in mice."7.83Icariin reverses corticosterone-induced depression-like behavior, decrease in hippocampal brain-derived neurotrophic factor (BDNF) and metabolic network disturbances revealed by NMR-based metabonomics in rats. ( Gong, MJ; Han, B; Liang, SW; Wang, SM; Zou, ZJ, 2016)
" Since the BDNF hypothesis of depression postulates that a reduction in BDNF is directly involved in the pathophysiology of depression, we evaluated the anti-depressive effects of HMF in mice with subcutaneously administered corticosterone at a dose of 20 mg/kg/day for 25 days."7.833,5,6,7,8,3',4'-Heptamethoxyflavone, a Citrus Flavonoid, Ameliorates Corticosterone-Induced Depression-like Behavior and Restores Brain-Derived Neurotrophic Factor Expression, Neurogenesis, and Neuroplasticity in the Hippocampus. ( Amakura, Y; Furukawa, Y; Nakajima, M; Okuyama, S; Sawamoto, A; Yamamoto, K; Yoshimura, M, 2016)
"In order to relieve anxiety and depression accompanying stress, physicians resort to tricyclic antidepressants, such as imipramine."7.83Antidepressant imipramine diminishes stress-induced inflammation in the periphery and central nervous system and related anxiety- and depressive- like behaviors. ( Ramirez, K; Sheridan, JF, 2016)
" In this study, we used the chronic corticosterone (CORT)-induced mouse model of anxiety/depression to assess antidepressant-like effects of baicalin and illuminate possible molecular mechanisms by which baicalin affects GR-mediated hippocampal neurogenesis."7.83Baicalin promotes hippocampal neurogenesis via SGK1- and FKBP5-mediated glucocorticoid receptor phosphorylation in a neuroendocrine mouse model of anxiety/depression. ( Dong, Y; Ma, J; Pan, X; Su, G; Wang, F; Wu, C; Yang, J; Zhang, K, 2016)
"The aim of the present study was to investigate the effects of the selective agonists of the corticotropin-releasing factor (CRF) 2 receptor, urocortin 2 (UCN 2) and urocortin 3 (UCN 3), on the anxiety- and depression-like signs induced by acute nicotine withdrawal in mice."7.83Selective CRF2 receptor agonists ameliorate the anxiety- and depression-like state developed during chronic nicotine treatment and consequent acute withdrawal in mice. ( Bagosi, Z; Balangó, B; Bokor, P; Buzás, A; Csabafi, K; Jászberényi, M; Palotai, M; Pintér, D; Simon, B; Szabó, G, 2016)
" We found that chronic treatment of a mouse model of anxiety/depression (CORT model) with a selective serotonin reuptake inhibitor (SSRI, fluoxetine, 18mg/kg/day) reversed CORT-induced anxiety/depression-like behavior in mice."7.81Nrf2-signaling and BDNF: A new target for the antidepressant-like activity of chronic fluoxetine treatment in a mouse model of anxiety/depression. ( Ali, ZE; Damiens, MH; David, DJ; Gardier, AM; Kerdine-Römer, S; Mendez-David, I; Pallardy, M; Tritschler, L, 2015)
"A mouse model of depression has been recently developed by exogenous corticosterone (CORT) administration, which has shown to mimic HPA-axis induced depression-like state in animals."7.81Resveratrol ameliorates depressive-like behavior in repeated corticosterone-induced depression in mice. ( Ali, SH; Bodduluru, LN; K V, A; Kasala, ER; Lahkar, M; Madhana, RM; Mahareddy, JR; Pitta, S, 2015)
" We compared the effects of chronic treatment with the preferential nNOS inhibitor 7-nitroindazole (7-NI) with those evoked by the conventional antidepressant fluoxetine on alterations that are considered as markers of depression (immobility in the forced swimming test, FST, decreased body weight gain and increased plasma corticosterone concentration) and cardiovascular changes caused by CVS."7.81Effects of nitric oxide synthesis inhibitor or fluoxetine treatment on depression-like state and cardiovascular changes induced by chronic variable stress in rats. ( Almeida, J; Crestani, CC; Duarte, JO; Oliveira, LA, 2015)
"Repeated injection of corticosterone (CORT) induces dysregulation in the hypothalamic-pituitary-adrenal (HPA) axis, resulting in depression."7.81Angelica gigas ameliorate depression-like symptoms in rats following chronic corticosterone injection. ( Hahm, DH; Lee, B; Lee, H; Shim, I; Sur, B, 2015)
" At 12 months, but not earlier, DEX-exposed mice displayed depression-like behavior and impaired hippocampal neurogenesis, not reversible by the antidepressant fluoxetine (FLX)."7.81Alterations in circadian entrainment precede the onset of depression-like behavior that does not respond to fluoxetine. ( Bose, R; Ceccatelli, S; Conti, M; DuPont, C; Onishchenko, N; Raciti, M; Spulber, S, 2015)
" This study was carried out in order to assess the influence of neonatal tactile stimulation (TS) on behavioral and morphological responses related to depression-like and anxiety-like behaviors, assessed following the administration of sertraline (SERT), a selective serotonin re-uptake inhibitor (SSRI)."7.81Neonatal tactile stimulation decreases depression-like and anxiety-like behaviors and potentiates sertraline action in young rats. ( Antoniazzi, CT; Barcelos, RC; Burger, ME; Duarte, MM; Duarte, T; Freitas, D; Metz, VG; Segat, HJ; Vey, LT, 2015)
"The aim of this study was to examine changes in rat emotional behavior and determine differences in the expression of GABA-A receptor alpha-2 subunits in brain structures of low- (LR) and high-anxiety (HR) rats after the repeated corticosterone administration."7.80The effect of chronic administration of corticosterone on anxiety- and depression-like behavior and the expression of GABA-A receptor alpha-2 subunits in brain structures of low- and high-anxiety rats. ( Krząścik, P; Lehner, M; Płaźnik, A; Skórzewska, A; Wisłowska-Stanek, A; Ziemba, A, 2014)
" Herein, we have described a mouse model of a depression-like and insulin-resistant (DIR) state induced by the co-treatment of high-fat diet (HFD) and corticosterone (CORT)."7.80Depression-like behaviors in mice subjected to co-treatment of high-fat diet and corticosterone are ameliorated by AICAR and exercise. ( Ji, L; Li, H; Liu, W; Zhai, X, 2014)
"Female rats implanted with 28-day osmotic minipumps delivering the SSRI escitalopram throughout pregnancy had serum escitalopram concentrations in a clinically observed range (17-65 ng/ml)."7.79Prenatal exposure to escitalopram and/or stress in rats: a prenatal stress model of maternal depression and its treatment. ( Boss-Williams, KA; Bourke, CH; Capello, CF; Owens, MJ; Rogers, SM; Stowe, ZN; Weiss, JM; Yu, ML, 2013)
"Ablation of olfactory bulbs caused depression-like symptoms as evidenced by increased immobility time in FST, hyperactivity in open field arena, and anhedonic like response in SPT along with alterations in mitochondrial enzyme complexes, increased serum corticosterone levels and oxidative damage."7.79Suppression of neuroinflammatory and apoptotic signaling cascade by curcumin alone and in combination with piperine in rat model of olfactory bulbectomy induced depression. ( Garg, S; Kumar, A; Rinwa, P, 2013)
"To observe the effect of hesperidin on behavior and hypothalamic-pituitary-adrenal (HPA) axis of ratmodel of chronic stress-induced depression."7.79[Effect of hesperidin on behavior and HPA axis of rat model of chronic stress-induced depression]. ( Cai, L; Li, R; Wu, QQ; Wu, TN, 2013)
"The antidepressant effect of a compound formed by co-ultramicronized palmitoylethanolamide (PEA) and luteolin (PEA+luteolin) was investigated in a mouse model of anxiety/depressive-like behavior."7.79Effects of palmitoylethanolamide and luteolin in an animal model of anxiety/depression. ( Ahmad, A; Campolo, M; Crupi, R; Cuzzocrea, S; Esposito, E; Paterniti, I, 2013)
"This study is to investigate the amelioration effect of glucocorticoid receptor (GR) antagonist mifepristone on the changes of learning and memory abilities in rat model of depression."7.79[Mifepristone repairs alteration of learning and memory abilities in rat model of depression]. ( Chen, NH; Li, J; Liu, Y; Sun, JD; Yuan, YH, 2013)
" This study examined the effects of mGlu2/3 receptor antagonists in chronic corticosterone-treated mice which could be used as an animal model of depression."7.79Metabotropic glutamate 2/3 receptor antagonists improve behavioral and prefrontal dopaminergic alterations in the chronic corticosterone-induced depression model in mice. ( Ago, Y; Araki, R; Baba, A; Chaki, S; Hashimoto, H; Hiramatsu, N; Kawasaki, T; Kita, Y; Matsuda, T; Nakazato, A; Onoe, H; Takuma, K; Yano, K, 2013)
" This study was designed to investigate the effects of Pb(2+)exposure on growth rate, locomotor activity, anxiety, depression, plasma corticosterone and brain serotonin (5-HT) levels in rats."7.79Alteration in plasma corticosterone levels following long term oral administration of lead produces depression like symptoms in rats. ( Batool, Z; Haider, S; Haleem, DJ; Inam, QU; Khaliq, S; Parveen, T; Saleem, S; Shamim, S; Tabassum, S, 2013)
" We have developed a mouse model of anxiety/depression based on addition of corticosterone to drinking water."7.78Functional status of somatodendritic serotonin 1A autoreceptor after long-term treatment with fluoxetine in a mouse model of anxiety/depression based on repeated corticosterone administration. ( David, DJ; Gardier, AM; Guiard, BP; Nguyen, HT; Quesseveur, G; Rainer, Q, 2012)
"Sub-chronic tryptophan depletion (SCTD) is proposed as an animal model for depression."7.78Sub-chronic dietary tryptophan depletion--an animal model of depression with improved face and good construct validity. ( Bermudez, I; Franklin, M; Gaburro, S; Murck, H; Singewald, N, 2012)
"Both chronic mild stress and an injection of corticosterone induce depression-like states in rodents."7.78Corticosterone reduces brain mitochondrial function and expression of mitofusin, BDNF in depression-like rodents regardless of exercise preconditioning. ( Liu, W; Zhou, C, 2012)
" In the present study, pain sensitivity was assessed in a mouse model of anxiety/depression on the basis of chronic corticosterone (CORT) administration through the drinking water (CORT model)."7.78Antinociceptive effects of fluoxetine in a mouse model of anxiety/depression. ( Coudoré, F; David, DJ; Gardier, AM; Guiard, BP; Hache, G; Le Dantec, Y; Orvoën, S, 2012)
"We examined a potential two-hit murine animal model of depression by assessing whether a genetic deficit in reelin increases vulnerability to the depressogenic effects of the stress hormone corticosterone."7.77Reelin as a putative vulnerability factor for depression: examining the depressogenic effects of repeated corticosterone in heterozygous reeler mice. ( Caruncho, HJ; Kalynchuk, LE; Lussier, AL; Romay-Tallón, R, 2011)
"The authors examined whether the spared nerve injury model of neuropathic pain induces depressive behavior in rats, using sucrose preference test and forced swim test, and tested whether a subanesthetic dose of ketamine treats spared nerve injury-induced depression."7.77A single subanesthetic dose of ketamine relieves depression-like behaviors induced by neuropathic pain in rats. ( Blanck, TJ; Eberle, SE; Goffer, Y; Shamir, DB; Tukey, DS; Wang, J; Xu, D; Ziff, EB; Zou, AH, 2011)
"We examined the potential of cysteamine, a neuroprotective compound to attenuate anxiety and depression like behaviors in a mouse model of anxiety/depression induced by chronic corticosterone exposure."7.77Cysteamine attenuates the decreases in TrkB protein levels and the anxiety/depression-like behaviors in mice induced by corticosterone treatment. ( Kutiyanawalla, A; Pillai, A; Terry, AV, 2011)
"Neonatal treatment with clomipramine (CMI) in rats induces multiple behavioral alterations during adulthood that resemble certain symptoms of human depression, such as impairments of pleasure-seeking behaviors."7.76Circadian activity of corticosterone in an animal model of depression: response to muscarinic cholinergic stimulation. ( Arteaga-Silva, M; Bonilla-Jaime, H; Hernández-González, M; Retana-Márquez, S; Vázquez-Palacios, G, 2010)
" Prolonged elevated levels of glucocorticoids are associated with depression and we developed an animal model of postpartum depression/stress based on high levels of corticosterone (CORT) during the postpartum."7.76Chronic corticosterone during pregnancy and postpartum affects maternal care, cell proliferation and depressive-like behavior in the dam. ( Brummelte, S; Galea, LA, 2010)
"We have recently shown that repeated high dose injections of corticosterone (CORT) reliably increase depression-like behavior on a modified one-day version of the forced swim test."7.75Repeated exposure to corticosterone increases depression-like behavior in two different versions of the forced swim test without altering nonspecific locomotor activity or muscle strength. ( Fournier, NM; Kalynchuk, LE; Marks, W, 2009)
"Repeated injection of corticosterone (CORT) induces dysregulation in the HPA axis, resulting in depression and anxiety."7.75Effects of acupuncture on chronic corticosterone-induced depression-like behavior and expression of neuropeptide Y in the rats. ( Hahm, DH; Lee, B; Lee, HJ; Shim, I; Yang, Y, 2009)
" The atypical antipsychotic risperidone and the selective serotonin (5-HT)(2) antagonist ritanserin normalized the depression-like behavior in PACAP-/- mice."7.75Depression-like behavior in the forced swimming test in PACAP-deficient mice: amelioration by the atypical antipsychotic risperidone. ( Baba, A; Guo, X; Hashimoto, H; Hashimoto, R; Hatanaka, M; Morita, Y; Nagai, K; Shintani, N; Takeda, M; Tanaka, K; Tanida, M; Yamamoto, A, 2009)
" Here we describe a mouse model of an anxiety/depressive-like state induced by chronic corticosterone treatment."7.75Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression. ( Antonijevic, IA; Artymyshyn, RP; Craig, DA; David, DJ; Drew, M; Gardier, AM; Gerald, C; Guiard, BP; Guilloux, JP; Hen, R; Leonardo, ED; Marsteller, D; Mendez, I; Rainer, Q; Samuels, BA; Wang, JW, 2009)
"Cholecystokinin (CCK) involvement in depression-like disorders is poorly documented."7.74Repeated social defeat-induced depression-like behavioral and biological alterations in rats: involvement of cholecystokinin. ( Becker, C; Benoliel, JJ; Blugeot, A; Hamon, M; Rivat, C; Zeau, B, 2008)
"A rat model of depression has been recently developed by exogenous corticosterone administration."7.74A mouse model of depression induced by repeated corticosterone injections. ( Du, L; Ma, R; Shen, J; Su, H; Xing, D; Zhao, Y, 2008)
"A dysregulated hypothalamic-pituitary-adrenal axis (HPA) has been implicated in major depressive disorder and most commonly used animal models of depression have been shown to elevate circulating levels of plasma corticosterone."7.74Chronic low dose corticosterone exposure decreased hippocampal cell proliferation, volume and induced anxiety and depression like behaviours in mice. ( Hutson, PH; Murray, F; Smith, DW, 2008)
"We investigated the influence of tiagabine on stress hormone release, cellular immune function and behaviour in rats following olfactory bulbectomy (OB), a well-recognized animal model of depression."7.74Tiagabine treatment is associated with neurochemical, immune and behavioural alterations in the olfactory bulbectomized rat model of depression. ( Dostalek, M; Jezova, D; Pistovcakova, J; Sulcova, A, 2008)
" The purpose of the present study was to characterize the effect of repeated corticosterone (CORT) injections and repeated restraint stress on anxiety and depression-like behavior in male rats."7.73Effect of repeated corticosterone injections and restraint stress on anxiety and depression-like behavior in male rats. ( Davis, AC; Gregus, A; Kalynchuk, LE; Wintink, AJ, 2005)
"Topiramate is currently used in the treatment of epilepsy, but this anticonvulsant drug has also been reported to exert mood-stabilizing effects and induce weight loss in patients."7.72Topiramate normalizes hippocampal NPY-LI in flinders sensitive line 'depressed' rats and upregulates NPY, galanin, and CRH-LI in the hypothalamus: implications for mood-stabilizing and weight loss-inducing effects. ( Bolwig, G; Husum, H; Mathé, A; Termeer, E; Van Kammen, D, 2003)
"This experiment examined the effect of repeated corticosterone injections on anxiety and depression-like behavior in male and female rats."7.72Corticosterone increases depression-like behavior, with some effects on predator odor-induced defensive behavior, in male and female rats. ( Boudreau, D; Gregus, A; Kalynchuk, LE; Perrot-Sinal, TS, 2004)
"The effects of chronic corticosterone treatment (100 mg pellet implanted for 1 week) were assessed in animal tests of anxiety, exploration and motor activity, and changes in binding to 5-HT1A and 5-HT2A receptors, and the 5-HT transporter, were measured."7.69Decreased 5-HT1A and increased 5-HT2A receptor binding after chronic corticosterone associated with a behavioural indication of depression but not anxiety. ( Fernandes, C; File, SE; McEwen, BS; McKittrick, CR, 1997)
"Quercetin is a flavonoid compound, which has anti-inflammatory and antioxidant roles."5.91Quercetin mitigates depression-like behavior via the suppression of neuroinflammation and oxidative damage in corticosterone-induced mice. ( Ge, C; Lei, L; Wang, S; Wu, X, 2023)
"anxiety and depression) are commonly observed in patients with epilepsy and induce seizure aggravation."5.72Transcranial Direct Current Stimulation Reduces Anxiety, Depression and Plasmatic Corticosterone in a Rat Model of Atypical Generalized Epilepsy. ( Antunes, GF; Castro, MC; Germann, J; Gomes, GCV; Gouveia, FV; Martinez, RCR; Oliveira, CC; Pinto, TRC; Valle, AC, 2022)
"The success rate of the chronic pain-depression (CPD) model was 62."5.72A New Potential Antidepressant: Dexmedetomidine Alleviates Neuropathic Pain-Induced Depression by Increasing Neurogenesis in the Hippocampus. ( He, M; Xu, S; Zhang, X; Zhao, X; Zheng, X; Zhu, Z, 2022)
"Major depression is a leading contributor to the global burden of disease."5.72Lower antidepressant response to fluoxetine is associated with anxiety-like behavior, hippocampal oxidative imbalance, and increase on peripheral IL-17 and IFN-γ levels. ( Becker, G; Bochi, GV; Camargo, LFM; da Silva Carlotto, M; Dos Santos, BM; Fialho, MFP; Oliveira, SM; Pereira, GC; Pillat, MM; Piton, E; Ramanzini, LG; Trevisan, G; Zanchet, EM, 2022)
"Pregnancy is a very complex and highly stressful time in which women become more physically and emotionally vulnerable."5.72Swimming exercise strain-dependently affects maternal care and depression-related behaviors through gestational corticosterone and brain serotonin in postpartum dams. ( Ebrahimian, F; Masrour, FF; Najdi, N; Salari, AA, 2022)
"Depression is a common, chronic, and often recurrent serious mood disorder."5.72Neuroprotective and Antioxidant Effects of Riparin I in a Model of Depression Induced by Corticosterone in Female Mice. ( Adelvane de Paula Rodrigues, F; Barbosa-Filho, JM; Cavalcanti Capibaribe, VC; Chavez Gutierrez, SJ; de Castro Chaves, R; Ferreira de Oliveira, N; Florenço de Sousa, FC; Lopes Sales, IS; Maia Oliveira, IC; Maria de França Fonteles, M; Rodrigues de Carvalho, AM; Rodrigues, GC; Teodorio Vidal, LM; Vasconcelos Mallmann, AS, 2022)
"Depression was induced by 14 days of chronic restraint stress (CRS) daily for 4 h."5.62Therapeutic Potential of Curcumin in Reversing the Depression and Associated Pseudodementia via Modulating Stress Hormone, Hippocampal Neurotransmitters, and BDNF Levels in Rats. ( Afzal, A; Ahmad, S; Batool, Z; Haider, S; Kamil, N; Liaquat, L; Perveen, T; Sadir, S; Shahzad, S; Tabassum, S, 2021)
" For this purpose, different animal models are used to study routes and molecular changes involved in depression, among them the chronic administration of corticosterone."5.56Glucocorticoid and brain-derived neurotrophic factor relationship: a brief investigation into the model of depression by chronic administration of corticosterone. ( Bochi, GV; Burger, ME; Pereira, GC; Roversi, K; Trevisan, G, 2020)
"Corticosterone plasma level was increased in the CUMS compared to the non-stressed group (p < 0."5.56Valproic acid administration exerts protective effects against stress-related anhedonia in rats. ( Barati, M; Eslami, M; Goudarzi, M; Mehrabi, S; Nahavandi, A; Shahbazi, A, 2020)
"Hair corticosterone was also assayed by liquid chromatography-mass spectrometry."5.56Effects of Chronic Cannabidiol Treatment in the Rat Chronic Unpredictable Mild Stress Model of Depression. ( Albert, Á; Farkas, S; Ferencz, E; Gáll, Z; Kolcsár, M; Urkon, M; Vancea, S, 2020)
"Depression is recognized as a highly chronic and recurrent disorder."5.56Cyclical administration of corticosterone results in aggravation of depression-like behaviors and accompanying downregulations in reelin in an animal model of chronic stress relevant to human recurrent depression. ( Allen, J; Caruncho, HJ; Kalynchuk, LE; Kulhawy, EY; Lebedeva, KA, 2020)
"Depression is closely linked to hypothalamus-pituitary-adrenal axis hyperactivity."5.56Antidepressant-like mechanism of honokiol in a rodent model of corticosterone-induced depression. ( Chang, HS; Duan, XH; Hu, KL; Li, LN; Li, Y; Liu, M; Yu, X; Zhang, B, 2020)
"2-Phenethylamine (PEA) is a monoamine alkaloid that acts as a central nervous system stimulant in humans."5.562-Phenylethylamine (PEA) Ameliorates Corticosterone-Induced Depression-Like Phenotype via the BDNF/TrkB/CREB Signaling Pathway. ( Hwang, DY; Hyun, SA; Ka, M; Kim, HR; Ko, MY; Lee, BS; Lee, CY; Lee, YJ, 2020)
"Depression is a very common psychiatric disorder affecting approximately 300 million people worldwide with the prevalence being twice as high in women as in men."5.51Effect of Chronic Corticosterone Treatment on Depression-Like Behavior and Sociability in Female and Male C57BL/6N Mice. ( Berger, S; Gureczny, S; Horvath, O; Pollak, DD; Reisinger, SN, 2019)
"Depression is the leading cause of mental health-related disease globally, and it affects an estimated 300 million people worldwide."5.51Antidepressant activity of crocin-I is associated with amelioration of neuroinflammation and attenuates oxidative damage induced by corticosterone in mice. ( Fu, Z; Shen, Q; Wang, L; Xiao, Q; Xie, X; Xiong, Z; Yu, C; Zhou, J, 2019)
" RESULTS The results showed that the extract at the dosage of 50 and 100 mg/kg significantly (p<0."5.51Antidepressive Effects of Taraxacum Officinale in a Mouse Model of Depression Are Due to Inhibition of Corticosterone Levels and Modulation of Mitogen-Activated Protein Kinase Phosphatase-1 (Mkp-1) and Brain-Derived Neurotrophic Factor (Bdnf) Expression. ( Duan, H; Gao, C; Guo, B; Kong, S; Li, D; Liang, X, 2019)
"Treatment with crocin, exposure to wheel running activity, and the combined interventions alleviated both behavioral and morphological deficits induced by adolescent stress."5.51Beneficial Effects of Physical Activity and Crocin Against Adolescent Stress Induced Anxiety or Depressive-Like Symptoms and Dendritic Morphology Remodeling in Prefrontal Cortex in Adult Male Rats. ( Ghalandari-Shamami, M; Nourizade, S; Pakdel, R; Rashidy-Pour, A; Vafaei, AA; Yousefi, B, 2019)
"Quercetin treatment was found to significantly reduce anxiety-like behaviors in mTBI-induced mice."5.51Quercetin mitigates anxiety-like behavior and normalizes hypothalamus-pituitary-adrenal axis function in a mouse model of mild traumatic brain injury. ( Ghorbanihaghjo, A; Kosari-Nasab, M; Mesgari-Abbasi, M; Salari, AA; Shokouhi, G, 2019)
"Corticosterone treatment altered all parameters in behavioral tests, leading to a depressive- and anxious-like behavior."5.51Reversal effect of Riparin IV in depression and anxiety caused by corticosterone chronic administration in mice. ( Barbosa Filho, JM; Capibaribe, VCC; Chaves, RC; da Silva, DMA; de Carvalho, AMR; de Sousa, FCF; Gutierrez, SJC; Lopes, IS; Macêdo, DS; Mallmann, ASV; Oliveira, ICM; Oliveira, NF; Valentim, JT; Vasconcelos, SMM, 2019)
" We also examined whether Roman chamomile combined with clomipramine treatment affects hippocampal neurogenesis and serum corticosterone levels."5.51Roman chamomile inhalation combined with clomipramine treatment improves treatment-resistant depression-like behavior in mice. ( Hashikawa, N; Hashikawa-Hobara, N; Ishikawa, R; Otsuka, A, 2019)
"Depression is commonly associated with hypothalamic-pituitary adrenal (HPA) axis dysfunction that primarily manifests as aberrant glucocorticoid secretion."5.48Differential effects of imipramine and CORT118335 (Glucocorticoid receptor modulator/mineralocorticoid receptor antagonist) on brain-endocrine stress responses and depression-like behavior in female rats. ( Balmer, NJ; Caldwell, JL; Estrada, CM; Ghisays, V; Nguyen, ET; Solomon, MB; Streicher, J, 2018)
"Oxytocin (OXT) has been considered as a neuroregulator mediating social behaviors and stress-related disorders."5.48Injection of oxytocin into paraventricular nucleus reverses depressive-like behaviors in the postpartum depression rat model. ( Li, H; Li, X; Liu, B; Shi, C; Wang, H; Wang, T; Wang, Y; Wu, Y; Xu, ZD; Yang, Y; Zhang, P, 2018)
"Baicalin treatment inhibited APPL2/GR signaling pathway and improved neurogenesis at SVZ, OB, and hippocampus in APPL2 Tg mice and chronic corticosterone-induced depression mouse model."5.48Baicalin Modulates APPL2/Glucocorticoid Receptor Signaling Cascade, Promotes Neurogenesis, and Attenuates Emotional and Olfactory Dysfunctions in Chronic Corticosterone-Induced Depression. ( Deng, R; Du, Q; Gao, C; Li, W; Shen, J; Wang, Q; Xu, A, 2018)
"Corticosterone pre-treatment generated oxidative stress, altering antioxidant enzymes in the nervous tissue."5.48Antioxidant and antidepressant-like effects of Eugenia catharinensis D. Legrand in an animal model of depression induced by corticosterone. ( Alberton, MD; Barauna, SC; Brueckheimer, MB; de Albuquerque, CAC; de Gasper, AL; de Melo, DFM; Delwing-Dal Magro, D; Delwing-De Lima, D; Döhler, AW; Harger, MC; Maia, TP; Micke, GA; Sala, GABN; Siebert, DA, 2018)
"Insulin resistance has been identified as the key mechanism linking depression and diabetes."5.46Curcumin reverses the depressive-like behavior and insulin resistance induced by chronic mild stress. ( Li, YC; Li, YJ; Qiao, JY; Shen, JD; Wei, Y, 2017)
"Recently, depression has been envisioned as more than an alteration in neurotransmitters centered around receptor signaling pathways."5.46Fluoxetine coupled with zinc in a chronic mild stress model of depression: Providing a reservoir for optimum zinc signaling and neuronal remodeling. ( Omar, NN; Tash, RF, 2017)
"Comorbid depression was induced by five inescapable foot-shocks (2mA, 2ms duration) at 10s intervals on days 1, 5, 7, and 10."5.46Metformin and ascorbic acid combination therapy ameliorates type 2 diabetes mellitus and comorbid depression in rats. ( Kumar, M; Nayak, PK; Shivavedi, N; Tej, GNVC, 2017)
"Depression has become a common public health problem that is showing increasing prevalence."5.46Evaluation of the antidepressant-like effect of musk in an animal model of depression: how it works. ( Ayuob, NN, 2017)
"Depression is a common psychopathological disorders."5.43Zinc and imipramine reverse the depression-like behavior in mice induced by chronic restraint stress. ( Ding, Q; Huang, J; Li, H; Mo, F; Shen, H; Shen, Z; Tian, X; Wang, X, 2016)
"Musk has an antidepressant-like effect in an animal model of depression, so it is advisable to assess its efficacy in people continually exposed to stressors."5.43The antidepressant effect of musk in an animal model of depression: a histopathological study. ( Ahmed, SM; Ali, SS; Ayuob, NN; El Wahab, MGA; Suliaman, M, 2016)
" Chronic administration of BB effectively reversed these alterations."5.43Bilobalide alleviates depression-like behavior and cognitive deficit induced by chronic unpredictable mild stress in mice. ( Shui, L; Song, Z; Tai, F; Wang, S; Wu, R, 2016)
" Repeated CORT dosing caused depression-like behavior in mice as indicated by increased despair effects in forced swim test (FST) and anhedonia in sucrose preference test."5.42Effect of a novel 5-HT3 receptor antagonist 4i, in corticosterone-induced depression-like behavior and oxidative stress in mice. ( Gupta, D; Kurhe, Y; Radhakrishnan, M, 2015)
"Chronic pain and depression are two complex states that often coexist in the clinical setting and traditional antidepressants and analgesics have shown limited clinical efficacy."5.42m-Trifluoromethyl-diphenyl diselenide, a multi-target selenium compound, prevented mechanical allodynia and depressive-like behavior in a mouse comorbid pain and depression model. ( Brüning, CA; Duarte, MM; Gai, BM; Martini, F; Nogueira, CW; Sampaio, TB; Soares, SM, 2015)
"Anxiety and depression are common in diabetics."5.40Anxiety- and depression-like behavior are correlated with leptin and leptin receptor expression in prefrontal cortex of streptozotocin-induced diabetic rats. ( Agilkaya, S; Aksu, I; Ates, M; Baykara, B; Buyuk, E; Cetinkaya, C; Cingoz, S; Dayi, A; Kiray, M; Sisman, AR; Uysal, N, 2014)
"The corticosterone-treated rats showed significantly reduced sleep time, disinhibition of rapid-eye-movement (REM) sleep and altered power spectra during non-REM sleep."5.40Correlations between depression behaviors and sleep parameters after repeated corticosterone injections in rats. ( Cao, Q; Cui, SY; Cui, XY; Huang, YL; Li, SJ; Sheng, ZF; Wang, ZJ; Yu, B; Zhang, XQ; Zhang, YH, 2014)
" Additionally, the effects of chronic administration of the tricyclic antidepressant imipramine and the anti-TNF-α pentoxyphylline were investigated."5.40Lipopolysaccharide repeated challenge followed by chronic mild stress protocol introduces a combined model of depression in rats: reversibility by imipramine and pentoxifylline. ( Abd-Alkhalek, HA; Abdel-tawab, AM; Aboul-Fotouh, S; El Tabbal, M; Elgarf, AS; Farrag, KA; Hammouda, GA; Hassan, AN; Kassim, SK, 2014)
"Corticosterone treatment induced longer immobility times in the FST, reflecting depressive-like behaviour."5.40Long-term corticosterone exposure decreases insulin sensitivity and induces depressive-like behaviour in the C57BL/6NCrl mouse. ( Blokland, A; Cañete, R; Pawluski, JL; Sierksma, AS; Steinbusch, HW; Vaessen, KR; van Donkelaar, EL, 2014)
"Honokiol (HNK) is a biphenolic neolignan possessing multiple biological activities including antioxidant, anti-inflammatory, anxiolytic, antidepressant and neuroprotective."5.40Honokiol abrogates lipopolysaccharide-induced depressive like behavior by impeding neuroinflammation and oxido-nitrosative stress in mice. ( Baruah, CC; Dwivedi, S; Hazarika, NK; Jangra, A; Kumar, P; Lahkar, M; Sulakhiya, K, 2014)
"Depression has been considered to be both a symptom and risk factor of AD."5.39Effects of corticosterone and amyloid-beta on proteins essential for synaptic function: implications for depression and Alzheimer's disease. ( Chang, RC; Cheng, SS; Ho, YS; Hung, CH; Law, AC; Wong, GT; Wuwongse, S; Zhang, NQ, 2013)
"Corticosterone secretion was significantly high in the ELF-MF-exposed mice; however, no changes were observed in the amount of the adrenocorticotropic hormone and the expression of genes related to stress response."5.39Chronic exposure to an extremely low-frequency magnetic field induces depression-like behavior and corticosterone secretion without enhancement of the hypothalamic-pituitary-adrenal axis in mice. ( Aoi, S; Kitamura, M; Kitaoka, K; Shimizu, N; Yoshizaki, K, 2013)
"Treatment with mifepristone decreased immobility and increased swimming (but not climbing) behavior in the FST, consistent with anti-depressant action."5.36Mifepristone decreases depression-like behavior and modulates neuroendocrine and central hypothalamic-pituitary-adrenocortical axis responsiveness to stress. ( Herman, JP; Solomon, MB; Wulsin, AC, 2010)
"Phenelzine did not increase paraventricular hypothalamus CRH or vasopressin mRNA in ADX mice lacking corticosterone replacement."5.33Chronic treatment with the monoamine oxidase inhibitor phenelzine increases hypothalamic-pituitary-adrenocortical activity in male C57BL/6 mice: relevance to atypical depression. ( Han, J; Jacobson, L; Kier, A, 2005)
"Electroconvulsive seizure (ECS)-treatment, an animal model for the antidepressant treatment electroconvulsive therapy, can enhance proliferation of glial cells."5.33Corticosterone-induced inhibition of gliogenesis in rat hippocampus is counteracted by electroconvulsive seizures. ( Ekstrand, J; Hellsten, J; Lindgren, H; Tingström, A; Wennström, M, 2006)
"Corticosterone treatment was found to induce a significant attenuation in the response to 8-OHDPAT, indicating functional desensitization of somatodendritic 5-HT(1A) autoreceptors."5.32Flattening the corticosterone rhythm attenuates 5-HT1A autoreceptor function in the rat: relevance for depression. ( Gartside, SE; Ingram, CD; Leitch, MM; McQuade, R; Young, AH, 2003)
" In this study we have evaluated the MMP-9 activity and protein expression in brain areas relevant to depression using the chronic corticosterone mouse model of depression."4.31Brain matrix metalloproteinase-9 activity is altered in the corticosterone mouse model of depression. ( Breviario, S; Castro, E; Díaz, Á; Florensa-Zanuy, E; Garro-Martínez, E; Pazos, Á; Pilar-Cuéllar, F; Senserrich, J, 2023)
" Thereafter, behavior parameters (sucrose preference test, forced-swimming test, open-field test, body weight), pro-inflammatory cytokines, neurotransmitters, adrenocorticotropic hormone (ACTH), corticosterone (CORT), and liver biomarkers were studied."4.3118β-Glycyrrhetinic Acid Ameliorates Neuroinflammation Linked Depressive Behavior Instigated by Chronic Unpredictable Mild Stress via Triggering BDNF/TrkB Signaling Pathway in Rats. ( Gupta, GL; Sharma, L; Sharma, M, 2023)
"Ketamine is an anesthetic drug that has recently been approved for the treatment of treatment-resistant depression."4.31The Effects of Acute and Repeated Administration of Ketamine on Memory, Behavior, and Plasma Corticosterone Levels in Female Mice. ( Acevedo, J; Johnson, EM; Mugarura, NE; Siegel, JA; Welter, AL, 2023)
"Here, we employed mouse models of depression induced by chronic unpredictable stress exposure or corticosterone (CORT) stimulation."4.31MAD2B Blunts Chronic Unpredictable Stress and Corticosterone Stimulation-Induced Depression-Like Behaviors in Mice. ( Meng, X; Miao, C; Su, Y; Wang, XL; Zhang, C, 2023)
" Pups whose dams consumed the HFS diet during gestation and lactation exhibited increased depression-related behavior and baseline serum corticosterone levels, but no difference in peak levels in response to stress."4.31Comparison of maternal versus postweaning ingestion of a high fat, high sucrose diet on depression-related behavior, novelty reactivity, and corticosterone levels in young, adult rat offspring. ( Farber, C; Koh, GY; Lane, MA; McKenzie, A; Muraida, JD; Renteria, K; Ritter, J; Rivers, C; Zhu, J, 2023)
"The corticosterone (CORT)-induced depression mouse model was used to evaluate the therapeutic efficacy of JTW."4.12Anti-depressive effects of Jiao-Tai-Wan on CORT-induced depression in mice by inhibiting inflammation and microglia activation. ( Bai, G; Duan, L; Huang, S; Li, M; Lo, PC; Qiao, Y; Song, L; Wang, Q; Wei, S; Yang, C; Yang, Y; Zhang, B, 2022)
"Mirtazapine (MIRT) is a multi-target antidepressant used in treatment of severe depression with promising efficacy, but also with important side effects, mainly sedation and weight gain."4.12Lipoic acid prevents mirtazapine-induced weight gain in mice without impairs its antidepressant-like action in a neuroendocrine model of depression. ( Chaves Filho, AJM; Cunha, NL; De Oliveira, GMF; Gadelha Filho, CVJ; Jucá, PM; Macedo, DS; Oliveira, TQ; Soares, MVR; Vasconcelos, SMM; Viana, GA; Vieira, CFX, 2022)
"Selective serotonergic reuptake inhibitors, including fluoxetine (FLX), are the most commonly used for the treatment of major depression."4.12Galanin (1-15) Enhances the Behavioral Effects of Fluoxetine in the Olfactory Bulbectomy Rat, Suggesting a New Augmentation Strategy in Depression. ( Cantero-García, N; Díaz-Cabiale, Z; Flores-Burgess, A; Fuxe, K; Gago, B; García-Durán, L; Millón, C; Narváez, JA; Puigcerver, A; Santín, L, 2022)
" To evaluate the antidepressant-like effects of FMN, a mice model of depression was established by chronic corticosterone (CORT) injection."4.12The antidepressant-like effect of formononetin on chronic corticosterone-treated mice. ( Bai, M; Li, M; Li, Y; Lu, S; Xu, E; Zhang, C; Zhu, L, 2022)
" Changes of serotonin (5-HT), dopamine (DA), norepinephrine (NE), serum corticosterone (CORT), adrenocorticotropic hormone (ACTH), organ index, and histopathology in brain tissue, to explore the treatment and characteristics of total white glucosides in depression model, were prepared by different stimuli in 21 days."4.12Pharmacological Study on Total Glycosides of Xiebai Protecting against Depression Model. ( Jiang, M; Miao, M; Zhao, H, 2022)
"The aim of this study was to investigate the antidepressant effect of Jujuboside A (JuA) on corticosterone (CORT)-induced depression in mice and explore the underlying mechanisms."4.12Antidepressant effect of Jujuboside A on corticosterone-induced depression in mice. ( Gong, J; Li, H; Li, J; Xie, X; Zhang, T, 2022)
" PPD rat models were prepared by withdrawing hormone‑simulated pregnancy (HSP), and subjects were treated with paeoniflorin and fluoxetine or plasmids."4.12Paeoniflorin exhibits antidepressant activity in rats with postpartum depression via the TSPO and BDNF‑mTOR pathways. ( Chen, J; Hu, L; Peng, H; Yang, K; Zeng, X; Zhu, W, 2022)
"Sustained elevation of corticosterone (CORT) is one of the common causes of aging and major depression disorder."4.02Low corticosterone levels attenuate late life depression and enhance glutamatergic neurotransmission in female rats. ( Chen, NH; Chu, SF; Cui, LY; He, HY; He, WB; Wang, ZZ; Yang, B; Zhang, Z; Zhou, X, 2021)
" Thus, the effects of naringenin, a potent antioxidant, anti-inflammatory and neuroprotective bioflavonoid on hypoxic stress-induced depressive-like and anxiety-related behaviors in mice, and the underlying molecular mechanisms were evaluated in this study."4.02Naringenin improves depressive- and anxiety-like behaviors in mice exposed to repeated hypoxic stress through modulation of oxido-inflammatory mediators and NF-kB/BDNF expressions. ( Ajayi, AM; Bakre, AG; Ben-Azu, B; Femi-Akinlosotu, O; Olugbemide, AS; Umukoro, S, 2021)
"Emerging evidence has shown that ursolic acid exerts antidepressant-like effects, however, its ability to elicit an antidepressant-like response in rodents subjected to stress model that mimics behavioral and neurochemical alterations found in depression remains to be determined."4.02Ursolic acid abrogates depressive-like behavior and hippocampal pro-apoptotic imbalance induced by chronic unpredictable stress. ( Camargo, A; Colla, ARS; Lieberknecht, V; Pazini, FL; Rodrigues, ALS, 2021)
"Intranasal treatment with oxytocin showed beneficial effects in post-traumatic stress disorder and autism spectrum disorders; however, it was not investigated as much in depression."4.02Synergy of oxytocin and citalopram in modulating Itgb3/Chl1 interplay: Relevance to sensitivity to SSRI therapy. ( Batinić, B; Gurwitz, D; Israel-Elgali, I; Jukić, M; Oved, K; Pešić, V; Puškaš, N; Shomron, N; Stanić, D, 2021)
" In this study, an ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed to detect the concentration of corticosterone (CORT) and its metabolites, progesterone (PROG) and testosterone in rat plasma and prefrontal cortex (PFC), and was applied to investigate the changes in hormones in rats with depression induced by chronic unpredictable mild stress (CUMS)."4.02Quantitation of six steroid hormones by ultra-performance liquid chromatography-tandem mass spectrometry in plasma and prefrontal cortex samples from rats with chronic unpredictable mild stress-induced depression. ( Han, X; Li, X; Lu, Y; Qin, Y; Rang, Y; Zhai, X; Zhu, Y, 2021)
" The treatments with ketamine, guanosine, and ketamine plus guanosine were effective to counteract corticosterone-induced anxiety-like phenotype, but not disturbances in the hippocampal NLRP3 pathway."4.02Low doses of ketamine and guanosine abrogate corticosterone-induced anxiety-related behavior, but not disturbances in the hippocampal NLRP3 inflammasome pathway. ( Camargo, A; Dalmagro, AP; Fraga, DB; Kaster, MP; Rodrigues, ALS; Rosa, JM; Zeni, ALB, 2021)
" Here, we assessed severity in a cognitive depression model by analysing indicators of stress and well-being, including physiological (body weight and corticosterone metabolite concentrations) and behavioural (nesting and burrowing behaviour) parameters."3.96Systematic analysis of severity in a widely used cognitive depression model for mice. ( Bleich, A; Brandwein, C; Chourbaji, S; Gass, P; Häger, C; Hellweg, R; Inta, D; Mallien, AS; Palme, R; Pfeiffer, N; Struve, B; Talbot, SR; Vogt, MA; Vollmayr, B, 2020)
" Here, we investigated the effects of stress exposure via two types of restraint apparatuses on body weight, locomotor activity, anxiety- and depression-related behaviors, and plasma corticosterone levels in mice."3.96Differential effects of stress exposure via two types of restraint apparatuses on behavior and plasma corticosterone level in inbred male BALB/cAJcl mice. ( Miyakawa, T; Shoji, H, 2020)
" Epilepsy-associated comorbid depression was evaluated by tail suspension test, sucrose preference test, and plasma corticosterone levels, whereas epilepsy-associated memory deficit condition was assessed by step-through paradigm, Morris water maze, and nitrite levels."3.96Exploring the ameliorative role of α7 neuronal nicotinic acetylcholine receptor modulation in epilepsy and associated comorbidities in post-PTZ-kindled mice. ( Goel, RK; Kaur, S; Sharma, NK, 2020)
" Body weight, levels of plasma corticosterone, hippocampal pro-and anti-inflammatory cytokines, anxiety-like (novelty suppressed feeding and elevated plus maze) and motivated behaviors (sucrose negative contrast test and forced swim test) were evaluated three days after the end of the chronic protocol."3.96Chronic unpredictable restraint stress increases hippocampal pro-inflammatory cytokines and decreases motivated behavior in rats. ( Covolan, L; da Silva, SG; Hamani, C; Mograbi, KM; Suchecki, D, 2020)
" Here we aimed to compare the effects of (R)-norketamine ((R)-NK), (S)-NK, (2R,6R)-HNK, and (2S,6S)-HNK in a mouse model of depression induced by chronic corticosterone (CORT) injection."3.96(S)-norketamine and (2S,6S)-hydroxynorketamine exert potent antidepressant-like effects in a chronic corticosterone-induced mouse model of depression. ( Ago, Y; Chen, L; Hashimoto, H; Hashimoto, K; Higuchi, M; Kasai, A; Naito, M; Nakagawa, S; Nakazawa, T; Seiriki, K; Tanabe, W; Tsukada, S; Yamaguchi, T; Yokoyama, R, 2020)
" Here, we decided to investigate how the duration of the CUMS procedure affects behavioural changes, body weight as well as the level of plasma corticosterone in stressed and nonstressed C57BL/6J mice subjected to CUMS for 18 or 36 days."3.96The influence of the duration of chronic unpredictable mild stress on the behavioural responses of C57BL/6J mice. ( Brański, P; Burnat, G; Pałucha-Poniewiera, A; Podkowa, K; Rafało-Ulińska, A, 2020)
"As a continuation of our previous experiments, this study aimed to investigate the antidepressant- and anxiolytic-like activity of pitolisant in mice using the corticosterone-induced depression model."3.96Pitolisant protects mice chronically treated with corticosterone from some behavioral but not metabolic changes in corticosterone-induced depression model. ( Kieć-Kononowicz, K; Kotańska, M; Mika, K; Pytka, K; Sapa, J; Sałaciak, K; Wheeler, L, 2020)
"Accordingly, we evaluated the effect of NAC on neonatal clomipramine (CLI)-induced adulthood anxiety and accompanying changes in plasma corticosterone levels, amygdalar volumes, neuronal/glial densities, levels of monoamines, and their metabolites in the amygdalar complex."3.96Mechanisms underlying remediation of depression-associated anxiety by chronic N-acetyl cysteine treatment. ( Chakraborty, S; Raju, TR; Shankaranarayana Rao, BS; Tripathi, SJ, 2020)
" Considering that ketamine has significant knock-on effects, this study investigated the effects of a single coadministration with subthreshold doses of ketamine plus guanosine in a corticosterone (CORT)-induced animal model of depression and the role of anti-inflammatory and antioxidant pathways."3.96Subthreshold doses of guanosine plus ketamine elicit antidepressant-like effect in a mouse model of depression induced by corticosterone: Role of GR/NF-κB/IDO-1 signaling. ( B Zeni, AL; Camargo, A; Dalmagro, AP; M Rosa, J; P Kaster, M; S Rodrigues, AL; Tasca, CI, 2020)
"This study assessed the effect of swimming training on anxiety-like behaviors and corticosterone."3.96The Effect of Swimming on Anxiety-Like Behaviors and Corticosterone in Stressed and Unstressed Rats. ( Aligholi, H; Brand, S; Koushkie Jahromi, M; Rezaei, R; Safari, MA, 2020)
" The maternal separation model involving three hour daily maternal separation (MS) from pups on PPD 2-15 on anxiety-, depression- and anhedonia-like behaviors in the dams was investigated, together with plasma corticosterone, oxytocin and D1-D2 heteromer expression in the NAc core and shell in non-MS and MS dams."3.96Maternal Separation Model of Postpartum Depression: Potential Role for Nucleus Accumbens Dopamine D1-D2 Receptor Heteromer. ( George, SR; Hasbi, A; Milenkovic, M; Noori, M; Sivasubramanian, M, 2020)
"A total of 36 rats were randomly assigned to three groups: a normal group, model group (depression), and treatment group (depression + gentiopicroside)."3.91Metabolomic evidence for the therapeutic effect of gentiopicroside in a corticosterone-induced model of depression. ( Cui, Q; Liu, Z; Wang, C; Wang, G; Yao, T; Zhang, Q, 2019)
"Chronic corticosterone (CORT) stress is an anxiety and depression inducing factor that involves the dysfunction of glucocorticoid receptor (GR), brain-derived neurotrophic factor (BDNF), and neuronal plasticity."3.91Proteomic profiling of the neurons in mice with depressive-like behavior induced by corticosterone and the regulation of berberine: pivotal sites of oxidative phosphorylation. ( Du, LJ; Feng, YL; Gao, HW; Gong, Q; He, LL; Lei, F; Li, J; Luo, YY; Wang, ML; Yan, XJ; Yang, SL, 2019)
" A treatment with escitalopram reversed depression-like behavior accompanied by reductions in BDNF levels in serum and the nucleus accumbens, while a treatment with blonanserin ameliorated abnormal social interaction behavior with reductions in serum BDNF levels."3.91Antidepressant activities of escitalopram and blonanserin on prenatal and adolescent combined stress-induced depression model: Possible role of neurotrophic mechanism change in serum and nucleus accumbens. ( Deriha, K; Furuse, K; Hashiguchi, H; Hashimoto, E; Ishii, T; Kawanishi, C; Kigawa, Y; Shiraishi, M; Tayama, M; Ukai, W, 2019)
" This study investigated antidepressant-like effects and possible underlying mechanisms of Lactobacillus paracasei PS23 (PS23), live or heat-killed, in a mouse model of corticosterone-induced depression using fluoxetine as standard drug."3.91Antidepressant-like activities of live and heat-killed Lactobacillus paracasei PS23 in chronic corticosterone-treated mice and possible mechanisms. ( Cheng, YF; Hsu, CC; Liao, CL; Tsai, YC; Wang, S; Wei, CL; Wu, CC; Yen, JT, 2019)
" We then measured the body weight and performed the sucrose preference test, forced swimming test (FST) and open field test to detect the effects of stress on anhedonia and activity."3.91DNA methylation of the Tacr2 gene in a CUMS model of depression. ( Fu, L; Liu, Z; Wan, Q; Wang, G; Xiang, D; Xiao, J; Xiao, L; Yao, L; Zhu, F, 2019)
" An animal model of chronic administration of high dose corticosterone to induce depression- and anxiety-like behavior and reduced neurogenesis was used to explore the biological changes brought by aromatherapy."3.91Lavender essential oil ameliorates depression-like behavior and increases neurogenesis and dendritic complexity in rats. ( Chow, JK; Fung, TK; Lau, BW; Lau, WK; Po, KK; Sánchez-Vidaña, DI; So, PK; Tsang, HW, 2019)
" This study utilized a translational animal model of maternal depression (based on giving high levels of corticosterone (CORT, 40 mg/kg, s."3.91Developmental outcomes after gestational antidepressant treatment with sertraline and its discontinuation in an animal model of maternal depression. ( Brummelte, S; Kott, JM; Mooney-Leber, SM, 2019)
"Chronic methamphetamine (MA) use can lead to increased symptoms of depression and anxiety during abstinence."3.91Stress-induced neural activation is altered during early withdrawal from chronic methamphetamine. ( Brooks, ML; Jacobskind, JS; Rosinger, ZJ; Zuloaga, DG, 2019)
"Our previous finding demonstrated that chronic corticosterone (CORT) may be involved in mediating the pathophysiology of premature aging in rats."3.91Exposure to jet lag aggravates depression-like behaviors and age-related phenotypes in rats subject to chronic corticosterone. ( Fu, Z; Ni, Y; Shen, Q; Wang, X; Wu, J; Xiao, Q; Xie, X; Yu, C; Zhou, J, 2019)
"20(S)-Protopanaxadiol (PPD) is a basic aglycone of the dammarane triterpenoid saponins and exerts antidepressant-like effects on behaviour in the forced swimming test (FST) and tail suspension test (TST) and in rat olfactory bulbectomy depression models."3.91Antidepressant-like effects of 20(S)-protopanaxadiol in a mouse model of chronic social defeat stress and the related mechanisms. ( Huang, H; Jiang, N; Liu, XM; Lu, C; Lv, GH; Lv, JW; Wang, HX; Wang, Q; Xia, TJ; Yang, YJ, 2019)
" In this study, we examined the molecular effects associated with a response to a week-long treatment with escitalopram in the chronic escape deficit (CED) model, a validated model of depression based on the induction of an escape deficit after exposure of rats to an unavoidable stress."3.88Molecular changes associated with escitalopram response in a stress-based model of depression. ( Alboni, S; Benatti, C; Blom, JMC; Brunello, N; Mendlewicz, J; Tascedda, F, 2018)
"Many models, such as chronic mild stress, chronic stress or chronic corticosterone injections are used to induce depression associated with cognitive deficits."3.88Combined corticosterone treatment and chronic restraint stress lead to depression associated with early cognitive deficits in mice. ( Bahane, DAN; Bum, EN; Ngoupaye, GT; Yassi, FB, 2018)
"Oral administration of WGE improved depression-like behaviors and stress-induced elevations of corticosterone."3.88Antidepressant-like effects of water extract of Gastrodia elata Blume on neurotrophic regulation in a chronic social defeat stress model. ( Chou, ST; Ho, CT; Lai, YS; Lin, SH; Lin, YE; Lu, KH; Panyod, S; Sheen, LY, 2018)
" The sucrose consumption test, forced swim test (FST) and the level of plasma corticosterone (CORT) were employed to evaluate depression-like symptoms in rats."3.88Blue light filtered white light induces depression-like responses and temporary spatial learning deficits in rats. ( Chu, H; Hao, W; Hou, X; Jiang, J; Lian, Y; Meng, Q; Pan, Y; Shang, L; Wang, W; Wei, X, 2018)
" Magnolol, main constituent identified in the barks of Magnolia officinalis, exerted antidepressant effects in a rat model of depression induced by chronic unpredictable mild stress in previous studies."3.88Antidepressant effects of magnolol in a mouse model of depression induced by chronic corticosterone injection. ( Bai, Y; Dai, G; Jing, W; Ju, W; Song, L; Xu, M; Zhang, W; Zhu, L, 2018)
"To investigate the effects of stress-induced depression, in the present study, we evaluated behavior by forced swimming test (FST), corticosterone plasma level by ELISA assay, hippocampal mRNA expression of three genes (NGF, kinesin and dynein) via real-time PCR and hippocamp count by Nissl staining in male Wistar rats."3.88Axonal transport proteins and depressive like behavior, following Chronic Unpredictable Mild Stress in male rat. ( Bakhtiarzadeh, F; Goudarzi, M; Nahavandi, A; Niknazar, S; Rakhshan, K; Shirvalilou, S, 2018)
" Therefore, we tested this hypothesis in the depression model of chronic administration of corticosterone (CORT) in mice and treated the animals daily with liraglutide (5 or 20 nmol/kg ip."3.88Liraglutide attenuates the depressive- and anxiety-like behaviour in the corticosterone induced depression model via improving hippocampal neural plasticity. ( Birong, L; Christian, H; Feiyu, S; Le, W; Weina, H; Yuhu, N, 2018)
" We also assessed maternal behaviours and 2 stress markers: basal vs acute-evoked stress levels of serum corticosterone and body weight gain."3.88Effects of prenatal stress on anxiety- and depressive-like behaviours are sex-specific in prepubertal rats. ( Arriagada-Solimano, M; Dagnino-Subiabre, A; Iturra-Mena, AM; Luttecke-Anders, A, 2018)
" As expected, CVS significantly increased anxiety- and depressive-like behaviors and corticosterone levels and decreased GFAP expression in astroglia, although this did not reflect a change in the total number of astroglial cells."3.88Profiling changes in cortical astroglial cells following chronic stress. ( Coppola, G; Hayley, S; McQuaid, RJ; Rudyk, CA; Salmaso, N; Simard, S, 2018)
" Indeed, PRS increased Sub offspring's serum corticosterone, and exaggerated their anxiety- and depressive-like behavior, while Dom offspring remained resilient to the hormonal and behavioral consequences of PRS."3.88Social dominance predicts hippocampal glucocorticoid receptor recruitment and resilience to prenatal adversity. ( Gross, M; Miller, A; Pinhasov, A; Romi, H, 2018)
" The present study aimed to examine effects on regional brain activity of two frequently used depression models, the chronic unpredictable mild stress (CUMS)- and the chronic corticosterone (CORT) depression model."3.88Regional alterations of cerebral [ ( Baeken, C; Brans, B; De Vos, F; Descamps, B; Dockx, R; Goethals, I; Pauwelyn, G; Peremans, K; Van Laeken, N; Vanhove, C, 2018)
" This study aimed to investigate the activity of RIP II in a corticosterone-induced depression mice model."3.88Riparin II ameliorates corticosterone-induced depressive-like behavior in mice: Role of antioxidant and neurotrophic mechanisms. ( Barbosa Filho, JM; Capibaribe, VCC; Chaves, RC; da Silva, DMA; de Araújo, MA; de Sousa, FCF; de Souza, AG; Gutierrez, SJC; Lopes, IS; Macêdo, DS; Oliveira, ICM; Valentim, JT, 2018)
" We used a well-characterized anxiety/depressive-like mouse model consisting of continuous input of corticosterone for seven consecutive weeks."3.88Adiporon, an adiponectin receptor agonist acts as an antidepressant and metabolic regulator in a mouse model of depression. ( Bayer, P; Béchade, C; Chabry, J; Debayle, D; Gay, AS; Guyon, A; Heurteaux, C; Maroteaux, L; Nicolas, S, 2018)
" The corticosterone rat model was developed to understand the influence of stress on depression-like symptomatology."3.88Depression-like behaviors induced by chronic corticosterone exposure via drinking water: Time-course analysis. ( Cui, SY; Cui, XY; Ding, H; Hu, X; Liu, YT; Ye, H; Zhang, YH; Zhao, HL, 2018)
"In recent years, a substantial amount of experimental studies have demonstrated that exogenous administration of corticosterone causes anxiety and depressive-like behaviour in rodents which involves hypothalamic-pituitary-adrenal axis dysregulation."3.85Mangiferin prevents corticosterone-induced behavioural deficits via alleviation of oxido-nitrosative stress and down-regulation of indoleamine 2,3-dioxygenase (IDO) activity. ( Deng, WT; Gao, QW; Liu, L; Luo, GQ; Wu, XN; Xiang, W, 2017)
"Administration of the acidic solution potentiated dentin hypersensitivity and increased corticosterone levels in the ED group compared with the WD group."3.85Depressive behavior induced by unpredictable chronic mild stress increases dentin hypersensitivity in rats. ( Barbosa, FM; Bonamin, LV; Bondan, EF; Cabral, D; de Fátima Monteiro Martins, M; Kabadayan, F; Kirsten, TB; Martha Bernardi, M; Queiroz-Hazarbassanov, N; Saraceni, CHC, 2017)
"To further explore the underlying antidepressant mechanism of ginseng total saponins (GTS), this study observed the effects on hippocampal astrocyte structural plasticity and hippocampal volume in the corticosterone-induced mouse depression model."3.85Preventive Effects of Ginseng Total Saponins on Chronic Corticosterone-Induced Impairment in Astrocyte Structural Plasticity and Hippocampal Atrophy. ( Chen, L; Dai, JG; Huang, YF; Lin, ZX; Wang, X; Zhao, YN, 2017)
"The benefits of creatine supplementation have been reported in a broad range of central nervous system diseases, including depression, although the mechanisms underlying these effects remain to be understood."3.85Creatine Prevents Corticosterone-Induced Reduction in Hippocampal Proliferation and Differentiation: Possible Implication for Its Antidepressant Effect. ( Azevedo, D; Brocardo, PS; Colla, A; Cunha, MP; de Oliveira, J; Gil-Mohapel, J; Pazini, FL; Ramos-Hryb, AB; Rodrigues, ALS; Rosa, JM, 2017)
" We investigated whether neonatal blockade of the GABA-A receptors by bicuculline can alter anxiety- and depression-like behaviors, body weight, food intake, corticosterone and testosterone levels in adult mice (postnatal days 80-95)."3.85Neonatal blockade of GABA-A receptors alters behavioral and physiological phenotypes in adult mice. ( Amani, M; Salari, AA, 2017)
"Agmatine, an endogenous neuromodulator, is a potential candidate to constitute an adjuvant/monotherapy for the management of depression."3.83Agmatine, by Improving Neuroplasticity Markers and Inducing Nrf2, Prevents Corticosterone-Induced Depressive-Like Behavior in Mice. ( Buendia, I; Casas, AI; Cuadrado, A; Egea, J; Freitas, AE; Gómez-Rangel, V; Lopez, MG; Navarro, E; Ortiz, JA; Parada, E; Rodrigues, ALS; Ruiz-Nuño, A; Wojnicz, A, 2016)
"Ketamine has emerged as a novel strategy to treat refractory depression, producing rapid remission, but elicits some side effects that limit its use."3.83Creatine, Similar to Ketamine, Counteracts Depressive-Like Behavior Induced by Corticosterone via PI3K/Akt/mTOR Pathway. ( Colla, AR; Cunha, MP; Lieberknecht, V; Oliveira, Á; Pazini, FL; Rodrigues, AL; Rosa, JM, 2016)
"Earlier, we reported that elevated anxiety-like behavior and high aggression in aged retired breeder Long-Evans (L-E) rats was associated with increased plasma corticosterone and elevated oxidative stress levels."3.83Tempol protects sleep-deprivation induced behavioral deficits in aggressive male Long-Evans rats. ( Asghar, S; Atrooz, F; Salim, S; Solanki, N, 2016)
" Here we used a rodent model of anxiety/depression-like states, which is based on chronic CORT administration and studied the effects of the antidepressant fluoxetine (FLX) on behavior, olfaction, and adult neurogenesis in the dentate gyrus (DG), olfactory bulb (OB), and the olfactory epithelium (OE)."3.83Anxiety- and Depression-Like States Lead to Pronounced Olfactory Deficits and Impaired Adult Neurogenesis in Mice. ( de Chaumont, F; Denizet, M; Gabellec, MM; Guilloux, JP; Lazarini, F; Lledo, PM; Olivo-Marin, JC; Siopi, E, 2016)
"Previously published reports have revealed the antidepressant-like effects of icariin in a chronic mild stress model of depression and in a social defeat stress model in mice."3.83Icariin reverses corticosterone-induced depression-like behavior, decrease in hippocampal brain-derived neurotrophic factor (BDNF) and metabolic network disturbances revealed by NMR-based metabonomics in rats. ( Gong, MJ; Han, B; Liang, SW; Wang, SM; Zou, ZJ, 2016)
" In the current study the association between diurnal pattern of key phase markers (melatonin, corticosterone, and core body temperature) and anhedonic-like behavior was investigated using the highly validated rat chronic mild stress (CMS) model of depression."3.83Disturbed diurnal rhythm of three classical phase markers in the chronic mild stress rat model of depression. ( Bouzinova, EV; Christiansen, SL; Højgaard, K; Wiborg, O, 2016)
" We used several well-validated animal models of depression to assess the antidepressant-like activity of LPM580153, followed by a neurotransmitter uptake assay and a corticosterone-induced cell injury model to explore its mechanism of action."3.83Antidepressant-like Effects of LPM580153, A Novel Potent Triple Reuptake Inhibitor. ( Liu, Q; Meng, X; Shao, J; Tian, J; Wang, H; Ye, L; Zhang, F; Zhong, Y, 2016)
"The antidepressant-like effects of WGE and gastrodin might be mediated by the regulation of monoamine neurotransmitters, and therefore were beneficial in depression treatment as a complementary approach."3.83Antidepressant-like effects of water extract of Gastrodia elata Blume in rats exposed to unpredictable chronic mild stress via modulation of monoamine regulatory pathways. ( Chen, WC; Ho, CT; Lai, YS; Lin, SH; Lin, YE; Panyod, S; Sheen, LY, 2016)
" Since the BDNF hypothesis of depression postulates that a reduction in BDNF is directly involved in the pathophysiology of depression, we evaluated the anti-depressive effects of HMF in mice with subcutaneously administered corticosterone at a dose of 20 mg/kg/day for 25 days."3.833,5,6,7,8,3',4'-Heptamethoxyflavone, a Citrus Flavonoid, Ameliorates Corticosterone-Induced Depression-like Behavior and Restores Brain-Derived Neurotrophic Factor Expression, Neurogenesis, and Neuroplasticity in the Hippocampus. ( Amakura, Y; Furukawa, Y; Nakajima, M; Okuyama, S; Sawamoto, A; Yamamoto, K; Yoshimura, M, 2016)
"The corticosterone mouse model is widely used in preclinical research towards a better understanding of mechanisms of major depression."3.83Disruption of the HPA-axis through corticosterone-release pellets induces robust depressive-like behavior and reduced BDNF levels in mice. ( Albertini, G; Bentea, E; Demuyser, T; Deneyer, L; Massie, A; Smolders, I, 2016)
"In order to relieve anxiety and depression accompanying stress, physicians resort to tricyclic antidepressants, such as imipramine."3.83Antidepressant imipramine diminishes stress-induced inflammation in the periphery and central nervous system and related anxiety- and depressive- like behaviors. ( Ramirez, K; Sheridan, JF, 2016)
" We have made advantage of a model of depression based on tryptophan depletion in which we have previously demonstrated that the elevation of serum aldosterone precedes that of corticosterone."3.83Adipogenesis and aldosterone: a study in lean tryptophan-depleted rats. ( Csanova, A; Franklin, M; Hlavacova, N; Jezova, D; Pokusa, M; Zorad, S, 2016)
" In vivo study, oral administration of these four CHMs for 14 days reversed the elevated plasma corticosterone levels, body weight loss, decrease in proliferation of hippocampal precursor cells; they also inhibited hippocampal cell apoptosis, and exhibited an antidepressant-like effect in a depression-like mouse model induced by CMS."3.83Chinese herbal medicines promote hippocampal neuroproliferation, reduce stress hormone levels, inhibit apoptosis, and improve behavior in chronically stressed mice. ( Chiou, SH; Hong, CJ; Lu, SW; Pao, LH; Shih, JH; Sun, GG, 2016)
" In this study, we used the chronic corticosterone (CORT)-induced mouse model of anxiety/depression to assess antidepressant-like effects of baicalin and illuminate possible molecular mechanisms by which baicalin affects GR-mediated hippocampal neurogenesis."3.83Baicalin promotes hippocampal neurogenesis via SGK1- and FKBP5-mediated glucocorticoid receptor phosphorylation in a neuroendocrine mouse model of anxiety/depression. ( Dong, Y; Ma, J; Pan, X; Su, G; Wang, F; Wu, C; Yang, J; Zhang, K, 2016)
" Here we investigate the short- and long-term effects of adolescent chronic mild stress (CMS) on the emergence of anxiety-/depressive-like behaviors (open-field and forced swim test - FST) and on HPA activity (corticosterone and type 1 CRH receptor - CRHR1) in PAE male and female rats."3.83Short- and long-term effects of stress during adolescence on emotionality and HPA function of animals exposed to alcohol prenatally. ( Chew, L; Ellis, L; Mok, P; Raineki, C; Weinberg, J, 2016)
" We examined brain neuropeptide and glucocorticoid receptor (GR) expression, plasma corticosterone concentration rhythm and body temperature rhythm, together with depression- and anxiety-related behaviour."3.83Postnatal light alters hypothalamic-pituitary-adrenal axis function and induces a depressive-like phenotype in adult mice. ( Canal, MM; Coleman, G; Gigg, J, 2016)
"It suggested that HCPE could improve the depression-like emotional status and associated cognitive deficits in CUMS rats, which might be mediated by regulation of neurotransmitters and BDNF levels in brain, alleviation of corticosterone level as well as the alleviation of oxidative stress."3.83Antidepressant-like effects and cognitive enhancement of the total phenols extract of Hemerocallis citrina Baroni in chronic unpredictable mild stress rats and its related mechanism. ( Aibai, S; Dong, LM; Le Zhai, J; Liao, YH; Liu, XM; Lu, C; Wang, KZ; Xu, P; Yang, Y, 2016)
"The aim of the present study was to investigate the effects of the selective agonists of the corticotropin-releasing factor (CRF) 2 receptor, urocortin 2 (UCN 2) and urocortin 3 (UCN 3), on the anxiety- and depression-like signs induced by acute nicotine withdrawal in mice."3.83Selective CRF2 receptor agonists ameliorate the anxiety- and depression-like state developed during chronic nicotine treatment and consequent acute withdrawal in mice. ( Bagosi, Z; Balangó, B; Bokor, P; Buzás, A; Csabafi, K; Jászberényi, M; Palotai, M; Pintér, D; Simon, B; Szabó, G, 2016)
" The trial's goal was to investigate the activity of Rip III in mice exposed to corticosterone-induced chronic depression model."3.81Subchronic administration of riparin III induces antidepressive-like effects and increases BDNF levels in the mouse hippocampus. ( Barbosa-Filho, JM; de França Fonteles, MM; de Sousa, FC; Gaspar, DM; Gutierrez, SJ; Oliveira, IC; Rodrigues, GC; Vasconcelos, AS; Vasconcelos, SM; Vidal, LT, 2015)
" Here, we show that EE efficiently reduces anxiety and depression-like behaviors in a mouse model of depression induced by long-term administration of corticosterone."3.81Neurogenesis-independent antidepressant-like effects of enriched environment is dependent on adiponectin. ( Chabry, J; Gandin, C; Glaichenhaus, N; Heurteaux, C; Nicolas, S; Petit-Paitel, A; Pietri, M; Veyssière, J; Zsürger, N, 2015)
" We found that chronic treatment of a mouse model of anxiety/depression (CORT model) with a selective serotonin reuptake inhibitor (SSRI, fluoxetine, 18mg/kg/day) reversed CORT-induced anxiety/depression-like behavior in mice."3.81Nrf2-signaling and BDNF: A new target for the antidepressant-like activity of chronic fluoxetine treatment in a mouse model of anxiety/depression. ( Ali, ZE; Damiens, MH; David, DJ; Gardier, AM; Kerdine-Römer, S; Mendez-David, I; Pallardy, M; Tritschler, L, 2015)
" Hypericin (HY) is the main components in SJW extracts, which is used to treat fatigue, weakness, and mild depression."3.81LC-MS/MS based studies on the anti-depressant effect of hypericin in the chronic unpredictable mild stress rat model. ( Chen, C; Chen, F; Lu, YN; Zhai, XJ; Zhu, CR, 2015)
"A mouse model of depression has been recently developed by exogenous corticosterone (CORT) administration, which has shown to mimic HPA-axis induced depression-like state in animals."3.81Resveratrol ameliorates depressive-like behavior in repeated corticosterone-induced depression in mice. ( Ali, SH; Bodduluru, LN; K V, A; Kasala, ER; Lahkar, M; Madhana, RM; Mahareddy, JR; Pitta, S, 2015)
" We compared the effects of chronic treatment with the preferential nNOS inhibitor 7-nitroindazole (7-NI) with those evoked by the conventional antidepressant fluoxetine on alterations that are considered as markers of depression (immobility in the forced swimming test, FST, decreased body weight gain and increased plasma corticosterone concentration) and cardiovascular changes caused by CVS."3.81Effects of nitric oxide synthesis inhibitor or fluoxetine treatment on depression-like state and cardiovascular changes induced by chronic variable stress in rats. ( Almeida, J; Crestani, CC; Duarte, JO; Oliveira, LA, 2015)
"Repeated injection of corticosterone (CORT) induces dysregulation in the hypothalamic-pituitary-adrenal (HPA) axis, resulting in depression."3.81Angelica gigas ameliorate depression-like symptoms in rats following chronic corticosterone injection. ( Hahm, DH; Lee, B; Lee, H; Shim, I; Sur, B, 2015)
" In the present study, animals exposed to the chronic unpredictable stress (CUS), a rodent model of depression, exhibited elevated corticosterone, depressive-like behavior, memory deficits, accompanied with decreased cAMP-PKA-CREB and cAMP-ERK1/2-CREB signaling and neuroplasticity."3.81Phosphodiesterase-4D Knock-down in the Prefrontal Cortex Alleviates Chronic Unpredictable Stress-Induced Depressive-Like Behaviors and Memory Deficits in Mice. ( Li, YF; Liu, YQ; O'Donnell, JM; Wang, ZZ; Wilson, SP; Xu, Y; Yang, WX; Zhang, HT; Zhang, Y; Zhang, YZ; Zhao, N, 2015)
" At 12 months, but not earlier, DEX-exposed mice displayed depression-like behavior and impaired hippocampal neurogenesis, not reversible by the antidepressant fluoxetine (FLX)."3.81Alterations in circadian entrainment precede the onset of depression-like behavior that does not respond to fluoxetine. ( Bose, R; Ceccatelli, S; Conti, M; DuPont, C; Onishchenko, N; Raciti, M; Spulber, S, 2015)
"Corticosterone, one of the glucocorticoids, is toxic to neurons and plays an important role in depressive-like behavior and depression."3.81H2S protects PC12 cells against toxicity of corticosterone by modulation of BDNF-TrkB pathway. ( Gao, S; Gu, H; Li, W; Tang, X; Tian, Y; Xiao, F; Zhang, P; Zou, W, 2015)
" This study was carried out in order to assess the influence of neonatal tactile stimulation (TS) on behavioral and morphological responses related to depression-like and anxiety-like behaviors, assessed following the administration of sertraline (SERT), a selective serotonin re-uptake inhibitor (SSRI)."3.81Neonatal tactile stimulation decreases depression-like and anxiety-like behaviors and potentiates sertraline action in young rats. ( Antoniazzi, CT; Barcelos, RC; Burger, ME; Duarte, MM; Duarte, T; Freitas, D; Metz, VG; Segat, HJ; Vey, LT, 2015)
" Dependent measures included tests utilizing object recognition (OR), Y-maze, elevated plus maze (EPM), forced swim (FST), blood alcohol content, corticosterone levels, and body weights."3.80Female rats exposed to stress and alcohol show impaired memory and increased depressive-like behaviors. ( Gomez, JL; Luine, VN, 2014)
"The aim of this study was to examine changes in rat emotional behavior and determine differences in the expression of GABA-A receptor alpha-2 subunits in brain structures of low- (LR) and high-anxiety (HR) rats after the repeated corticosterone administration."3.80The effect of chronic administration of corticosterone on anxiety- and depression-like behavior and the expression of GABA-A receptor alpha-2 subunits in brain structures of low- and high-anxiety rats. ( Krząścik, P; Lehner, M; Płaźnik, A; Skórzewska, A; Wisłowska-Stanek, A; Ziemba, A, 2014)
"In this study, a mouse model of anxiety/depressant-like behavior induced by long-term corticosterone treatment was used to evaluate behavioral, endocrinal, and neurochemical changes in mice and their possible modulation of F-DPS treatment."3.80An organoselenium compound improves behavioral, endocrinal and neurochemical changes induced by corticosterone in mice. ( Bortolatto, CF; Duarte, MM; Gai, BM; Heck, SO; Nogueira, CW; Stein, AL; Zeni, G, 2014)
" Herein, we have described a mouse model of a depression-like and insulin-resistant (DIR) state induced by the co-treatment of high-fat diet (HFD) and corticosterone (CORT)."3.80Depression-like behaviors in mice subjected to co-treatment of high-fat diet and corticosterone are ameliorated by AICAR and exercise. ( Ji, L; Li, H; Liu, W; Zhai, X, 2014)
" We investigated for the first time whether neonatal exposure to TNF-α can affect body weight, stress-induced corticosterone (COR), anxiety- and depression-related behaviors in adult mice."3.80Tumor necrosis factor-alpha during neonatal brain development affects anxiety- and depression-related behaviors in adult male and female mice. ( Babri, S; Doosti, MH; Salari, AA, 2014)
" Consistent with the anxiety profile, PDE4A KO mice had elevated corticosterone levels compared with wild-type controls post-stress."3.80Mice deficient in phosphodiesterase-4A display anxiogenic-like behavior. ( Conti, M; Hansen, RT; Zhang, HT, 2014)
" Previous studies using preproenkephalin knockout (PENK KO) mice showed that these animals exhibit abnormal stress reactivity and show increased anxiety behavior in acute stress situations."3.80Enkephalin knockout male mice are resistant to chronic mild stress. ( Bilkei-Gorzo, A; Drews, E; Melo, I; Zimmer, A, 2014)
" In this study, we investigated the antidepressant effect of GTS on the corticosterone-induced mouse depression model and explored the underlying mechanism."3.80The antidepressant effects of ginseng total saponins in male C57BL/6N mice by enhancing hippocampal inhibitory phosphorylation of GSK-3β. ( Chen, L; Dai, J; Huang, Y; Wang, Z; Zhang, H; Zhao, Y, 2014)
"Female rats implanted with 28-day osmotic minipumps delivering the SSRI escitalopram throughout pregnancy had serum escitalopram concentrations in a clinically observed range (17-65 ng/ml)."3.79Prenatal exposure to escitalopram and/or stress in rats: a prenatal stress model of maternal depression and its treatment. ( Boss-Williams, KA; Bourke, CH; Capello, CF; Owens, MJ; Rogers, SM; Stowe, ZN; Weiss, JM; Yu, ML, 2013)
"This study was designed to investigate the possible antidepressant effects of the antioxidant alpha-lipoic acid (ALA) as a stand-alone treatment or in association with desvenlafaxine (DVS) in the chronic corticosterone (CORT)-induced depression model."3.79Augmentation therapy with alpha-lipoic acid and desvenlafaxine: a future target for treatment of depression? ( Araújo, PV; da Silva, JC; de Oliveira, SL; de Sousa, CN; Macêdo, DS; Sampaio, LR; Silva, MC; Sousa, FC; Vasconcelos, SM; Ximenes, NC, 2013)
"Ablation of olfactory bulbs caused depression-like symptoms as evidenced by increased immobility time in FST, hyperactivity in open field arena, and anhedonic like response in SPT along with alterations in mitochondrial enzyme complexes, increased serum corticosterone levels and oxidative damage."3.79Suppression of neuroinflammatory and apoptotic signaling cascade by curcumin alone and in combination with piperine in rat model of olfactory bulbectomy induced depression. ( Garg, S; Kumar, A; Rinwa, P, 2013)
"To observe the effect of hesperidin on behavior and hypothalamic-pituitary-adrenal (HPA) axis of ratmodel of chronic stress-induced depression."3.79[Effect of hesperidin on behavior and HPA axis of rat model of chronic stress-induced depression]. ( Cai, L; Li, R; Wu, QQ; Wu, TN, 2013)
" We sought to determine whether postnatal NMDA receptor blockade can affect normal development of body weight, corticosterone levels, anxiety- and depression-related behaviors in male and female mice in adulthood."3.79Neonatal NMDA receptor blockade alters anxiety- and depression-related behaviors in a sex-dependent manner in mice. ( Amani, M; Azarfarin, M; Bakhtiari, A; Doosti, MH; Majidi-Zolbanin, N; Mirza-Rahimi, M; Salari, AA; Samadi, H, 2013)
" Moreover these rats exhibited anhedonia in a sucrose consumption test, and increased grooming in the open-field test, which reflects an anxiety-like condition."3.79Disruption of circadian rhythms due to chronic constant light leads to depressive and anxiety-like behaviors in the rat. ( Angeles-Castellanos, M; Escobar, C; Salgado-Delgado, R; Tapia-Osorio, A, 2013)
"The antidepressant effect of a compound formed by co-ultramicronized palmitoylethanolamide (PEA) and luteolin (PEA+luteolin) was investigated in a mouse model of anxiety/depressive-like behavior."3.79Effects of palmitoylethanolamide and luteolin in an animal model of anxiety/depression. ( Ahmad, A; Campolo, M; Crupi, R; Cuzzocrea, S; Esposito, E; Paterniti, I, 2013)
"This study is to investigate the amelioration effect of glucocorticoid receptor (GR) antagonist mifepristone on the changes of learning and memory abilities in rat model of depression."3.79[Mifepristone repairs alteration of learning and memory abilities in rat model of depression]. ( Chen, NH; Li, J; Liu, Y; Sun, JD; Yuan, YH, 2013)
" At the end of the diet regimen, we assessed anxiety and depressive-like behaviour, corticosterone levels and biochemical changes in the midbrain and limbic brain regions."3.79Diet-induced obesity promotes depressive-like behaviour that is associated with neural adaptations in brain reward circuitry. ( Fulton, S; Sharma, S, 2013)
" DHA deficiency during the preweaning period significantly increased and prolonged restraint stress-induced changes in colonic temperature and serum corticosterone levels, caused a significant increase in GABA(A) antagonist-induced heart rate changes and enhanced depressive-like behavior in the forced swimming test and anxiety-like behavior in the plus-maze test in later life."3.79Exposure to a maternal n-3 fatty acid-deficient diet during brain development provokes excessive hypothalamic-pituitary-adrenal axis responses to stress and behavioral indices of depression and anxiety in male rat offspring later in life. ( Chen, HF; Su, HM, 2013)
" This study examined the effects of mGlu2/3 receptor antagonists in chronic corticosterone-treated mice which could be used as an animal model of depression."3.79Metabotropic glutamate 2/3 receptor antagonists improve behavioral and prefrontal dopaminergic alterations in the chronic corticosterone-induced depression model in mice. ( Ago, Y; Araki, R; Baba, A; Chaki, S; Hashimoto, H; Hiramatsu, N; Kawasaki, T; Kita, Y; Matsuda, T; Nakazato, A; Onoe, H; Takuma, K; Yano, K, 2013)
"We investigated the effect of two well characterized preclinical animal models of depression - repeated injections of corticosterone (CORT) and repeated restraint stress - on markers of GABAergic and glutamatergic activity in the hippocampus and amygdala."3.79Altered GABAergic and glutamatergic activity within the rat hippocampus and amygdala in rats subjected to repeated corticosterone administration but not restraint stress. ( Caruncho, HJ; Kalynchuk, LE; Lussier, AL; Romay-Tallón, R, 2013)
"Several clinical reports have postulated a beneficial effect of the addition of a low dose of risperidone to the ongoing treatment with antidepressants in treatment-resistant depression."3.78Effect of co-treatment with fluoxetine or mirtazapine and risperidone on the active behaviors and plasma corticosterone concentration in rats subjected to the forced swim test. ( Gądek-Michalska, A; Kabziński, M; Rachwalska, P; Rogóż, Z; Sadaj, W, 2012)
" Behavioral responses associated with the CeA, such as anxiety, depression and fear memory, and the plasma corticosterone levels were evaluated under both basal and stressful conditions."3.78Site-specific genetic manipulation of amygdala corticotropin-releasing factor reveals its imperative role in mediating behavioral response to challenge. ( Chen, A; Gil, S; Regev, L; Tsoory, M, 2012)
" We created an animal model of postpartum stress/depression based on administering high levels of corticosterone (CORT) to the dams during the postpartum period which caused behavioral changes and reduced hippocampal cell proliferation in the offspring."3.78Gestational and postpartum corticosterone exposure to the dam affects behavioral and endocrine outcome of the offspring in a sexually-dimorphic manner. ( Brummelte, S; Galea, LA; Lieblich, SE, 2012)
" Aim of this paper was to study the relationship between neuroendocrine activation (circulating corticosterone and brain BDNF levels) and a wide array of depression- and anxiety-like behaviours (anhedonia, behavioural despair, generalised and social anxiety) resulting from exposure to chronic stress."3.78Social deprivation stress is a triggering factor for the emergence of anxiety- and depression-like behaviours and leads to reduced brain BDNF levels in C57BL/6J mice. ( Alleva, E; Bellisario, V; Berry, A; Calza, A; Capoccia, S; Cirulli, F; Tirassa, P, 2012)
"Sub-chronic tryptophan depletion (SCTD) is proposed as an animal model for depression."3.78Sub-chronic dietary tryptophan depletion--an animal model of depression with improved face and good construct validity. ( Bermudez, I; Franklin, M; Gaburro, S; Murck, H; Singewald, N, 2012)
" This study aimed to examine the antidepressant-like effect and the possible mechanisms of total glycosides of peony (TGP) in the CORT-induced depression model in rats."3.78Peony glycosides reverse the effects of corticosterone on behavior and brain BDNF expression in rats. ( Che, CT; Huang, Z; Ip, SP; Mao, QQ; Xian, YF, 2012)
" In this study, we used the chronic mild stress (CMS) rat model of depression, which is based on continuous exposure to unpredictable stressors, to track longitudinal changes in HPA function using fecal corticosterone metabolites (FCM) as a read out."3.78Circadian activity of the hypothalamic-pituitary-adrenal axis is differentially affected in the rat chronic mild stress model of depression. ( Bouzinova, EV; Christiansen, S; Palme, R; Wiborg, O, 2012)
"Both chronic mild stress and an injection of corticosterone induce depression-like states in rodents."3.78Corticosterone reduces brain mitochondrial function and expression of mitofusin, BDNF in depression-like rodents regardless of exercise preconditioning. ( Liu, W; Zhou, C, 2012)
"On the basis of CMS-induced changes of sucrose intake, a reliable measure for anhedonia, rats were divided into "resilient" and "anhedonic" groups."3.78Chronic mild stress-induced depression-like symptoms in rats and abnormalities in catecholamine uptake in small arteries. ( Aalkjaer, C; Boedtkjer, DB; Bouzinova, EV; Broegger, T; Matchkov, VV; Møller-Nielsen, N; Wiborg, O, 2012)
" In the present study, pain sensitivity was assessed in a mouse model of anxiety/depression on the basis of chronic corticosterone (CORT) administration through the drinking water (CORT model)."3.78Antinociceptive effects of fluoxetine in a mouse model of anxiety/depression. ( Coudoré, F; David, DJ; Gardier, AM; Guiard, BP; Hache, G; Le Dantec, Y; Orvoën, S, 2012)
" Both the females that cohabited with the stressed males and those that cohabited with their male offspring showed behavioral (including anxiety- and depression-like behaviors), physiological (decreased body weight and basal corticosterone levels) and neurobiological symptoms (increased activity in dorsal raphe serotonergic neurons in response to an unfamiliar male) resembling the alterations described in abused and depressed women."3.78Evidence for biological roots in the transgenerational transmission of intimate partner violence. ( Ansermet, F; Cordero, MI; Fontana, X; Marquez, C; Poirier, GL; Salehi, B; Sandi, C; Veenit, V, 2012)
") on the behavior, brain-derived neurotrophic factor (BDNF) and its receptor (TrkB) in depression-like rats induced by exogenous administration of the stress hormone corticosterone (40mg/kg, s."3.78Ethanol extracts from Hemerocallis citrina attenuate the decreases of brain-derived neurotrophic factor, TrkB levels in rat induced by corticosterone administration. ( Jiang, M; Li, HC; Li, J; Su, BF; Yang, KF; Yi, LT; Zhang, YT; Zhou, Y, 2012)
" The oral administration of these three CHMs for 14 days reversed not only the elevation of plasma corticosterone levels and body weight loss, but also the decreasing of hippocampal precursor cell proliferation and abnormal behavior in the CMS induced depression-like mouse model."3.78Three Chinese herbal medicines promote neuroproliferation in vitro, and reverse the effects of chronic mild stress on behavior, the HPA axis, and proliferation of hippocampal precursor cell in vivo. ( Chiou, SH; Lu, SW; Ma, KH; Pao, LH; Sun, GG, 2012)
"We examined a potential two-hit murine animal model of depression by assessing whether a genetic deficit in reelin increases vulnerability to the depressogenic effects of the stress hormone corticosterone."3.77Reelin as a putative vulnerability factor for depression: examining the depressogenic effects of repeated corticosterone in heterozygous reeler mice. ( Caruncho, HJ; Kalynchuk, LE; Lussier, AL; Romay-Tallón, R, 2011)
" In controls, CUS resulted in the development of chronic stress state characterized by typical somatic (body weight reduction, thymus involution) and endocrine changes (resting plasma ACTH and corticosterone elevation and POMC mRNA elevation in anterior lobe of the pituitary)."3.77Lack of vasopressin does not prevent the behavioural and endocrine changes induced by chronic unpredictable stress. ( Bagdy, G; Barna, I; Domokos, A; Jankord, R; Varga, J; Zelena, D, 2011)
" Subordinate 129SvEv mice showed body weight gain, hyperphagia, increased adipose fat pads weight and basal plasma corticosterone."3.77Vulnerability to chronic subordination stress-induced depression-like disorders in adult 129SvEv male mice. ( Bartolomucci, A; Ceresini, G; Dadomo, H; Di Cristo, L; Lori, A; Malinge, I; Palanza, P; Parmigiani, S; Sanghez, V; Sheardown, M, 2011)
" Behavior in the elevated plus maze (EPM; anxiety) and forced swimming test (FST; depression) as well as adrenocorticotropin and corticosterone hormone levels were measured at postpartum days 23-25 and at adult age."3.77Changes in adaptability following perinatal morphine exposure in juvenile and adult rats. ( Fürst, Z; Gyarmati, Z; Klausz, B; Pintér, O; Sobor, M; Tímár, J; Zelena, D, 2011)
" The present study was designed to investigate the effect of Hypericum perforatum treatment in a mouse model of anxiety/depressive-like behavior, induced by chronic corticosterone administration."3.77Hypericum perforatum treatment: effect on behaviour and neurogenesis in a chronic stress model in mice. ( Battaglia, F; Bramanti, P; Crupi, R; Cuzzocrea, S; La Spada, G; Marino, A; Mazzon, E; Spina, E, 2011)
"A rat model of depression has been recently developed using exogenous corticosterone (CORT) administration."3.77Curcumin reverses corticosterone-induced depressive-like behavior and decrease in brain BDNF levels in rats. ( Feng, CR; Huang, Z; Li, ZY; Mao, QQ; Pan, AJ; Zhong, XM, 2011)
" In this study, the adult male offspring of dams exposed to restraint stress during the last semester of pregnancy and fed different diets were evaluated for depressive-like behavior in the forced swimming test and for the corticosterone response to the test."3.77Effect of fish oil and coconut fat supplementation on depressive-type behavior and corticosterone levels of prenatally stressed male rats. ( Borsonelo, EC; Galduróz, JC; Suchecki, D, 2011)
" When the animals reached adulthood, the groups were subdivided and the rats were submitted or not to CVS, which consisted of daily exposure to different stressors for 40 days, followed by a period of behavioral tasks, biochemical (plasma corticosterone and insulin sensitivity) and neurochemical (Na⁺,K⁺-ATPase activity in hippocampus, amygdala and parietal cortex) measurements."3.77Association between Na⁺,K⁺-ATPase activity and the vulnerability/resilience to mood disorders induced by early life experience. ( Benetti, Cda S; Dalmaz, C; Lucion, AB; Mattos, CB; Portella, AK; Scherer, EB; Silveira, PP; Wyse, AT; Zugno, AI, 2011)
"In this study, we find that ICS exposure causes a transient increase in plasma corticosterone concentration, but not in anxiety or depression-like behaviors."3.77Permanent relief from intermittent cold stress-induced fibromyalgia-like abnormal pain by repeated intrathecal administration of antidepressants. ( Araki, K; Kishioka, S; Mukae, T; Nagai, J; Nishiyori, M; Uchida, H; Ueda, H, 2011)
"The authors examined whether the spared nerve injury model of neuropathic pain induces depressive behavior in rats, using sucrose preference test and forced swim test, and tested whether a subanesthetic dose of ketamine treats spared nerve injury-induced depression."3.77A single subanesthetic dose of ketamine relieves depression-like behaviors induced by neuropathic pain in rats. ( Blanck, TJ; Eberle, SE; Goffer, Y; Shamir, DB; Tukey, DS; Wang, J; Xu, D; Ziff, EB; Zou, AH, 2011)
" Our study showed that stress reduced body weight, decreased sucrose intake and sucrose preference, and increased immobility in a forced swimming test."3.77Exposure to enriched environment restores the mRNA expression of mineralocorticoid and glucocorticoid receptors in the hippocampus and ameliorates depressive-like symptoms in chronically stressed rats. ( Liu, H; Sun, H; Yang, Y; Yao, Z; Zhang, J; Zhang, L, 2011)
" Experiment 2 showed that fluoxetine treatment administered via drinking water attenuated depressive-like behaviour in the FST and TST in individually housed female C57BL/6J mice, but had no effect on anxiety-like behaviour."3.76The lonely mouse: verification of a separation-induced model of depression in female mice. ( Brown, RE; Martin, AL, 2010)
"Neonatal treatment with clomipramine (CMI) in rats induces multiple behavioral alterations during adulthood that resemble certain symptoms of human depression, such as impairments of pleasure-seeking behaviors."3.76Circadian activity of corticosterone in an animal model of depression: response to muscarinic cholinergic stimulation. ( Arteaga-Silva, M; Bonilla-Jaime, H; Hernández-González, M; Retana-Márquez, S; Vázquez-Palacios, G, 2010)
" These indices were depression-like behavior (increased immobility time in the forced-swim test) and acute restraint stress-induced changes in hypothalamo-pituitary-adrenocortical (HPA) axis activity [plasma corticosterone (CORT) and ACTH levels and the number of Fos-immunoreactive cells in the hypothalamic paraventricular nucleus (an index of neuronal activity)]."3.76"Green odor" inhalation by stressed rat dams reduces behavioral and neuroendocrine signs of prenatal stress in the offspring. ( Fujita, S; Miyoshi, M; Ueki, S; Watanabe, T, 2010)
" Prolonged elevated levels of glucocorticoids are associated with depression and we developed an animal model of postpartum depression/stress based on high levels of corticosterone (CORT) during the postpartum."3.76Chronic corticosterone during pregnancy and postpartum affects maternal care, cell proliferation and depressive-like behavior in the dam. ( Brummelte, S; Galea, LA, 2010)
"We studied the early and delayed effects of hypoxia during the infantile period on the behavioral reactions and corticosterone concentration in male rats."3.76Early and delayed effects of hypoxia during the infantile period on behavioral and hormonal reactions of rats. ( Bagaeva, TR; Butkevich, IP; Makukhina, GV; Mikhailenko, VA; Otellin, VA, 2010)
"We have recently shown that repeated high dose injections of corticosterone (CORT) reliably increase depression-like behavior on a modified one-day version of the forced swim test."3.75Repeated exposure to corticosterone increases depression-like behavior in two different versions of the forced swim test without altering nonspecific locomotor activity or muscle strength. ( Fournier, NM; Kalynchuk, LE; Marks, W, 2009)
"Repeated injection of corticosterone (CORT) induces dysregulation in the HPA axis, resulting in depression and anxiety."3.75Effects of acupuncture on chronic corticosterone-induced depression-like behavior and expression of neuropeptide Y in the rats. ( Hahm, DH; Lee, B; Lee, HJ; Shim, I; Yang, Y, 2009)
" The atypical antipsychotic risperidone and the selective serotonin (5-HT)(2) antagonist ritanserin normalized the depression-like behavior in PACAP-/- mice."3.75Depression-like behavior in the forced swimming test in PACAP-deficient mice: amelioration by the atypical antipsychotic risperidone. ( Baba, A; Guo, X; Hashimoto, H; Hashimoto, R; Hatanaka, M; Morita, Y; Nagai, K; Shintani, N; Takeda, M; Tanaka, K; Tanida, M; Yamamoto, A, 2009)
" Here we describe a mouse model of an anxiety/depressive-like state induced by chronic corticosterone treatment."3.75Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression. ( Antonijevic, IA; Artymyshyn, RP; Craig, DA; David, DJ; Drew, M; Gardier, AM; Gerald, C; Guiard, BP; Guilloux, JP; Hen, R; Leonardo, ED; Marsteller, D; Mendez, I; Rainer, Q; Samuels, BA; Wang, JW, 2009)
" The aim of this study was to determine short- and long-term effects of early postnatal hypoxia (on day 7) on depression- and pain-related behaviors and the plasma corticosterone levels."3.75Short- and long-term influences of hypoxia during early postnatal period of development on behavioral and hormonal responses in rats. ( Bagaeva, TR; Butkevich, IP; Makukhina, GV; Mikhailenko, VA; Otellin, VA, 2009)
" psychological (social defeat) stressors on anxiety- and depression-related behaviors, serum levels of corticosterone and the expression of plasticity-related genes CAM-L1, CREB, GAP-43, and laminin in the prefrontal cortex (PFC), the amygdala and the hippocampus."3.75Physical stress differs from psychosocial stress in the pattern and time-course of behavioral responses, serum corticosterone and expression of plasticity-related genes in the rat. ( Ben-Shachar, D; Kavushansky, A; Klein, E; Richter-Levin, G, 2009)
" However, LPS-induced fever, rises in plasma corticosterone, body weight loss and c-Fos expression in the hypothalamus and caudal brainstem were not altered by i."3.74Central nervous action of interleukin-1 mediates activation of limbic structures and behavioural depression in response to peripheral administration of bacterial lipopolysaccharide. ( Combe, C; Dantzer, R; Konsman, JP; Luheshi, GN; Poole, S; Veeneman, J, 2008)
"In controls, chronic mild stress resulted in symptoms of chronic stress state characterized by typical somatic (body weight reduction, thymus involution) and endocrine changes (resting plasma ACTH and corticosterone elevation and POMC mRNA elevation in anterior lobe of the pituitary)."3.74The role of vasopressin in chronic stress studied in a chronic mild stress model of depression. ( Bagdy, G; Barna, I; Csabail, K; Domokos, A; Makara, GB; Zelena, D, 2007)
"Cholecystokinin (CCK) involvement in depression-like disorders is poorly documented."3.74Repeated social defeat-induced depression-like behavioral and biological alterations in rats: involvement of cholecystokinin. ( Becker, C; Benoliel, JJ; Blugeot, A; Hamon, M; Rivat, C; Zeau, B, 2008)
"Chronic corticosterone injections induce hippocampus tissue damage and depression-like behavior in rodent animals, the cause of which is not known."3.74Chronic corticosterone injections induce a decrease of ATP levels and sustained activation of AMP-activated protein kinase in hippocampal tissues of male mice. ( Du, L; Li, B; Shen, J; Su, H; Xing, D; Zhao, Y, 2008)
"A rat model of depression has been recently developed by exogenous corticosterone administration."3.74A mouse model of depression induced by repeated corticosterone injections. ( Du, L; Ma, R; Shen, J; Su, H; Xing, D; Zhao, Y, 2008)
"A dysregulated hypothalamic-pituitary-adrenal axis (HPA) has been implicated in major depressive disorder and most commonly used animal models of depression have been shown to elevate circulating levels of plasma corticosterone."3.74Chronic low dose corticosterone exposure decreased hippocampal cell proliferation, volume and induced anxiety and depression like behaviours in mice. ( Hutson, PH; Murray, F; Smith, DW, 2008)
"We investigated the influence of tiagabine on stress hormone release, cellular immune function and behaviour in rats following olfactory bulbectomy (OB), a well-recognized animal model of depression."3.74Tiagabine treatment is associated with neurochemical, immune and behavioural alterations in the olfactory bulbectomized rat model of depression. ( Dostalek, M; Jezova, D; Pistovcakova, J; Sulcova, A, 2008)
" The purpose of the present study was to characterize the effect of repeated corticosterone (CORT) injections and repeated restraint stress on anxiety and depression-like behavior in male rats."3.73Effect of repeated corticosterone injections and restraint stress on anxiety and depression-like behavior in male rats. ( Davis, AC; Gregus, A; Kalynchuk, LE; Wintink, AJ, 2005)
"Administration of amphetamine (AMPH) can induce symptoms of psychosis in humans and locomotor sensitization in rats; in contrast, withdrawal from a period of AMPH intake is most often associated with symptoms of human endogenous depression."3.72Amphetamine withdrawal does not produce a depressive-like state in rats as measured by three behavioral tests. ( Feldon, J; Murphy, CA; Nanz-Bahr, NI; Pezze, MA; Pryce, CR; Russig, H, 2003)
"Topiramate is currently used in the treatment of epilepsy, but this anticonvulsant drug has also been reported to exert mood-stabilizing effects and induce weight loss in patients."3.72Topiramate normalizes hippocampal NPY-LI in flinders sensitive line 'depressed' rats and upregulates NPY, galanin, and CRH-LI in the hypothalamus: implications for mood-stabilizing and weight loss-inducing effects. ( Bolwig, G; Husum, H; Mathé, A; Termeer, E; Van Kammen, D, 2003)
"The humoral response and the role of catecholamines and corticosterone were analyzed in a chronic mild stress (CMS) model of depression."3.72Impaired T-cell dependent humoral response and its relationship with T lymphocyte sensitivity to stress hormones in a chronic mild stress model of depression. ( Ayelli-Edgar, V; Genaro, AM; Silberman, DM; Zieher, LM; Zorrilla-Zubilete, M, 2004)
"Behaviors reflecting anhedonia and/or anorexia, sickness behavior, plasma corticosterone and norepinephrine (NE) activity in the paraventricular nucleus (PVN) of the hypothalamus were assessed following continuous infusion of IL-2 over 7 days in CD-1 mice."3.72Influence of chronic interleukin-2 infusion and stressors on sickness behaviors and neurochemical change in mice. ( Anisman, H; Hayley, S; Sudom, K; Turrin, NP, 2004)
"This experiment examined the effect of repeated corticosterone injections on anxiety and depression-like behavior in male and female rats."3.72Corticosterone increases depression-like behavior, with some effects on predator odor-induced defensive behavior, in male and female rats. ( Boudreau, D; Gregus, A; Kalynchuk, LE; Perrot-Sinal, TS, 2004)
" These long-term neuroendocrinological effects are mediated, at least in part, by stress-induced maternal corticosterone increase during pregnancy and stress-induced maternal anxiety during the postnatal period."3.71Hormonal and behavioural abnormalities induced by stress in utero: an animal model for depression. ( Darnaudery, M; Maccari, S; Van Reeth, O, 2001)
"The effects of chronic corticosterone treatment (100 mg pellet implanted for 1 week) were assessed in animal tests of anxiety, exploration and motor activity, and changes in binding to 5-HT1A and 5-HT2A receptors, and the 5-HT transporter, were measured."3.69Decreased 5-HT1A and increased 5-HT2A receptor binding after chronic corticosterone associated with a behavioural indication of depression but not anxiety. ( Fernandes, C; File, SE; McEwen, BS; McKittrick, CR, 1997)
" The degree of anorexia and plasma corticosterone elevation in response to the stress was measured."3.67The effect of acute and chronic administration of desmethylimipramine on responses to stress in rats. ( Platt, JE; Stone, EA; Trullas, R, 1984)
"The enhanced inflammation and hypercortisolism that typically characterize stress-related illnesses, such as depression, metabolic syndrome, cardiovascular disease, or osteoporosis, may also be related to increased glucocorticoid resistance."2.48Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction. ( Silverman, MN; Sternberg, EM, 2012)
"Depression is one of the most common mood disturbances worldwide."1.91SNS alleviates depression-like behaviors in CUMS mice by regluating dendritic spines via NCOA4-mediated ferritinophagy. ( Ao, HQ; Chen, WC; Chen, WG; He, CY; He, SQ; Li, T; Lin, HS; Liu, Y; Song, ML; Sun, HT; Yang, XM; Zhang, MJ; Zhang, Y; Zhong, XD, 2023)
"Quercetin is a flavonoid compound, which has anti-inflammatory and antioxidant roles."1.91Quercetin mitigates depression-like behavior via the suppression of neuroinflammation and oxidative damage in corticosterone-induced mice. ( Ge, C; Lei, L; Wang, S; Wu, X, 2023)
"Depression is a common psychiatric disorder affecting around 300 million people worldwide."1.91Emotional behaviors as well as the hippocampal reelin expression in C57BL/6N male mice chronically treated with corticosterone. ( Hiramatsu, M; Ibi, D; Kinoshita, M; Nakasai, G; Sawahata, M; Takaba, R; Yamada, K, 2023)
"Anxious depression is a prevalent disease with devastating consequences."1.91Social avoidance and altered hypothalamic-pituitary-adrenal axis in a mouse model of anxious depression: The role of LPA ( Estivill-Torrús, G; Gómez-Salas, FJ; Moreno-Fernández, RD; Nieto-Quero, A; Pedraza, C; Rodríguez de Fonseca, F; Sampedro-Piquero, P; Santín, LJ, 2023)
"anxiety and depression) are commonly observed in patients with epilepsy and induce seizure aggravation."1.72Transcranial Direct Current Stimulation Reduces Anxiety, Depression and Plasmatic Corticosterone in a Rat Model of Atypical Generalized Epilepsy. ( Antunes, GF; Castro, MC; Germann, J; Gomes, GCV; Gouveia, FV; Martinez, RCR; Oliveira, CC; Pinto, TRC; Valle, AC, 2022)
"The success rate of the chronic pain-depression (CPD) model was 62."1.72A New Potential Antidepressant: Dexmedetomidine Alleviates Neuropathic Pain-Induced Depression by Increasing Neurogenesis in the Hippocampus. ( He, M; Xu, S; Zhang, X; Zhao, X; Zheng, X; Zhu, Z, 2022)
"Major depression is a leading contributor to the global burden of disease."1.72Lower antidepressant response to fluoxetine is associated with anxiety-like behavior, hippocampal oxidative imbalance, and increase on peripheral IL-17 and IFN-γ levels. ( Becker, G; Bochi, GV; Camargo, LFM; da Silva Carlotto, M; Dos Santos, BM; Fialho, MFP; Oliveira, SM; Pereira, GC; Pillat, MM; Piton, E; Ramanzini, LG; Trevisan, G; Zanchet, EM, 2022)
"Depression is a global health problem, and there is a pressing need for a better understanding of its pathogenesis."1.72Hippocampal semaphorin 3B improves depression-like behaviours in mice by upregulating synaptic plasticity and inhibiting neuronal apoptosis. ( Du, Y; Gao, Y; Gong, M; Guo, X; Hao, Y; Shi, H; Shi, M; Shi, Y; Song, H; Song, L; Wang, S; Wang, X; Zhao, Y, 2022)
"Pregnancy is a very complex and highly stressful time in which women become more physically and emotionally vulnerable."1.72Swimming exercise strain-dependently affects maternal care and depression-related behaviors through gestational corticosterone and brain serotonin in postpartum dams. ( Ebrahimian, F; Masrour, FF; Najdi, N; Salari, AA, 2022)
"Intestinal dysbacteriosis is associated with depression."1.72Antibiotics-induced depression in mice via the microbiota-gut-brain axis. ( Deng, H; Fan, X; Ji, H; Qiu, J; Shen, X, 2022)
"Depression has become an important disease threatening human health."1.72Mahonia Alkaloids (MA) Ameliorate Depression Induced Gap Junction Dysfunction by miR-205/Cx43 Axis. ( Chen, N; Chu, S; He, F; He, J; Lai, K; Li, D; Li, Y; Wang, S; Wei, D; Wei, G; Wei, J; Xie, J; Zhang, Z, 2022)
"Depression is positively correlated with the high incidence and low survival rate of cancers, while more cancer patients suffer depression."1.72The combination of chronic stress and smoke exacerbated depression-like changes and lung cancer factor expression in A/J mice: Involve inflammation and BDNF dysfunction. ( Li, KW; Liu, BP; Song, C; Zhang, C; Zhang, YP, 2022)
"Depression is a very common mental disorder and mechanism that is associated with mitochondrial dysfunction."1.72Antidepressant-Like Effects of Edaravone and Minocycline: Investigation of Oxidative Stress, Neuroinflammation, Neurotrophic, and Apoptotic Pathways. ( Bagheri, A; Motafeghi, F; Seyedabadi, M; Shaki, F; Shokrzadeh, M, 2022)
"Depression is a psychiatric disorder leading to anhedonia and lack of interest and motivation."1.72Antidepressive-Like Effect of ( Alhalmi, A; Kumar, G; Pathak, D; Sharma, A; Singh, T; Virmani, T, 2022)
"Depression is a common, chronic, and often recurrent serious mood disorder."1.72Neuroprotective and Antioxidant Effects of Riparin I in a Model of Depression Induced by Corticosterone in Female Mice. ( Adelvane de Paula Rodrigues, F; Barbosa-Filho, JM; Cavalcanti Capibaribe, VC; Chavez Gutierrez, SJ; de Castro Chaves, R; Ferreira de Oliveira, N; Florenço de Sousa, FC; Lopes Sales, IS; Maia Oliveira, IC; Maria de França Fonteles, M; Rodrigues de Carvalho, AM; Rodrigues, GC; Teodorio Vidal, LM; Vasconcelos Mallmann, AS, 2022)
"Rats with recurrent depression are highly susceptible to stress and exhibit depression-like behaviours such as weight loss, increased immobility time in tail suspension test, and reduced sucrose preference index."1.62Behavioral and Neurochemical Changes in Rats with Recurrent Depression induced by chronic unpredictable stress. ( Chen, L; Hong, C; Huang, Z; Kong, W; Qiu, F; Wang, L; Zhang, D; Zhang, G; Zhao, J; Zhong, X, 2021)
"Corticosterone (CORT) treatment significantly enhanced Bag-1/GR complex formation and GR mitochondrial translocation in cultured rat cortical neurons after treatment for 30 min and 24 hr."1.62Bag-1 mediates glucocorticoid receptor trafficking to mitochondria after corticosterone stimulation: Potential role in regulating affective resilience. ( Bao, H; Du, J; Feng, L; Hou, Y; Hunter, RG; Jia, Y; K Manji, H; Li, H; Luo, S; S McEwen, B; Wang, G; Xiao, C; Yuan, P; Zhang, Y, 2021)
"Major depressive disorder is a common debilitating mental health problem that represents one of the leading causes of disability."1.62Adult neurogenesis augmentation attenuates anhedonia and HPA axis dysregulation in a mouse model of chronic stress and depression. ( Belzung, C; Brizard, B; Eliwa, H; Hen, R; Le Guisquet, AM; Surget, A, 2021)
"Depression is a pervasive or persistent mental disorder that causes mood, cognitive and memory deficits."1.62Uncaria rhynchophylla ameliorates unpredictable chronic mild stress-induced depression in mice via activating 5-HT ( Dai, SF; Deng, XP; Huang, HL; Li, S; Liang, JH; Liu, CQ; Luan, ZL; Ma, XC; Qiao, YL; Sun, CP; Yu, ZL; Zhang, ZJ; Zhou, JJ, 2021)
"Depression is a psychiatric disorder with several comorbidities that has a complicated pathophysiology."1.62Exercise and fluoxetine treatment during adolescence protect against early life stress-induced behavioral abnormalities in adult rats. ( Amiri, S; Gauvin, E; Peeri, M; Pirri, F; Zolfaghari, FS, 2021)
"Depression was induced by 14 days of chronic restraint stress (CRS) daily for 4 h."1.62Therapeutic Potential of Curcumin in Reversing the Depression and Associated Pseudodementia via Modulating Stress Hormone, Hippocampal Neurotransmitters, and BDNF Levels in Rats. ( Afzal, A; Ahmad, S; Batool, Z; Haider, S; Kamil, N; Liaquat, L; Perveen, T; Sadir, S; Shahzad, S; Tabassum, S, 2021)
"Though the association between overactive bladder (OAB) and depression was noticed years ago, the pharmaceutical market does not offer one universal drug that would cure both conditions at the same time."1.56Duloxetine reverses the symptoms of overactive bladder co-existing with depression via the central pathways. ( Kociszewski, J; Poleszak, E; Serefko, A; Szopa, A; Wiśniewski, R; Woźniak, A; Wróbel, A, 2020)
" For this purpose, different animal models are used to study routes and molecular changes involved in depression, among them the chronic administration of corticosterone."1.56Glucocorticoid and brain-derived neurotrophic factor relationship: a brief investigation into the model of depression by chronic administration of corticosterone. ( Bochi, GV; Burger, ME; Pereira, GC; Roversi, K; Trevisan, G, 2020)
"Corticosterone plasma level was increased in the CUMS compared to the non-stressed group (p < 0."1.56Valproic acid administration exerts protective effects against stress-related anhedonia in rats. ( Barati, M; Eslami, M; Goudarzi, M; Mehrabi, S; Nahavandi, A; Shahbazi, A, 2020)
"Corticosterone treatment induced depression-like behaviors, it increased immobility time in the TST, OFT, and FST, decreased the number of movements in OFT, and decreased sucrose consumption."1.56Oleuropein Reverses Repeated Corticosterone-Induced Depressive-Like Behavior in mice: Evidence of Modulating Effect on Biogenic Amines. ( Al-Rasheed, N; Attia, HA; Badr, AM, 2020)
" Based on these findings, this study aimed to investigate the possible effects of Riparin IV (Rip IV) on cognitive impairment induced by chronic administration of corticosterone in mice."1.56The neuroprotective effect of Riparin IV on oxidative stress and neuroinflammation related to chronic stress-induced cognitive impairment. ( Barbosa Filho, JM; Barbosa, GR; Capibaribe, VCC; Chaves, RC; da Silva, DMA; de Carvalho, AMR; de Oliveira, NF; de Sousa, FCF; Fonteles, MMF; Gutierrez, SJC; Lopes, IS; Mallmann, ASV; Valentim, JT, 2020)
"Depression is one of the most common mood disorders, which affects one in six people at some point in life."1.56Apocynin as an antidepressant agent: in vivo behavior and oxidative parameters modulation. ( Bochi, GV; da Silva, RM; Dalenogare, DP; de Almeida, AS; Dos Santos, BM; Dos Santos, GT; Fialho, MFP; Marchesan, S; Moresco, RN; Pereira, GC; Piton, E; Schiefelbein, NS, 2020)
"Hair corticosterone was also assayed by liquid chromatography-mass spectrometry."1.56Effects of Chronic Cannabidiol Treatment in the Rat Chronic Unpredictable Mild Stress Model of Depression. ( Albert, Á; Farkas, S; Ferencz, E; Gáll, Z; Kolcsár, M; Urkon, M; Vancea, S, 2020)
" Therefore, the current study investigates the effects of chronic administration of the commercially available probiotic Bifidobacterium longum subsp."1.56Probiotic treatment (Bifidobacterium longum subsp. longum 35624™) affects stress responsivity in male rats after chronic corticosterone exposure. ( Brummelte, S; Haas, GS; Mooney-Leber, SM; Saffar, M; Wang, W, 2020)
"Caffeine has been known to combat stress-evoked depression."1.56New insights into the effects of caffeine on adult hippocampal neurogenesis in stressed mice: Inhibition of CORT-induced microglia activation. ( He, RR; Kurihara, H; Li, WX; Li, YF; Luo, Z; Mao, ZF; Ouyang, SH; Tu, LF; Wang, GE; Wu, YP; Zhang, QY, 2020)
"Depression is recognized as a highly chronic and recurrent disorder."1.56Cyclical administration of corticosterone results in aggravation of depression-like behaviors and accompanying downregulations in reelin in an animal model of chronic stress relevant to human recurrent depression. ( Allen, J; Caruncho, HJ; Kalynchuk, LE; Kulhawy, EY; Lebedeva, KA, 2020)
"The studies aimed to determine the antidepressant efficacy of single and chronic administration of dapoxetine alone and vortioxetine alone, as well as in the combination of these drugs."1.56Antistress and antidepressant properties of dapoxetine and vortioxetine. ( Kopciuch, D; Kus, K; Nowakowska, E; Paczkowska, A; Ratajczak, P; Skórczewska, B; Zaprutko, T; Zielińska-Przyjemska, M, 2020)
"Depression is closely linked to hypothalamus-pituitary-adrenal axis hyperactivity."1.56Antidepressant-like mechanism of honokiol in a rodent model of corticosterone-induced depression. ( Chang, HS; Duan, XH; Hu, KL; Li, LN; Li, Y; Liu, M; Yu, X; Zhang, B, 2020)
"All strains variously developed mechanical allodynia after SNI with the exception of stress-hyporesponsive LEW rats, despite all strains displaying similar functional gait-deficits after injury."1.56The influence of rat strain on the development of neuropathic pain and comorbid anxio-depressive behaviour after nerve injury. ( Abelson, KSP; Andersson, DR; Brønnum Pedersen, T; Finn, DP; Hestehave, S; Munro, G, 2020)
"2-Phenethylamine (PEA) is a monoamine alkaloid that acts as a central nervous system stimulant in humans."1.562-Phenylethylamine (PEA) Ameliorates Corticosterone-Induced Depression-Like Phenotype via the BDNF/TrkB/CREB Signaling Pathway. ( Hwang, DY; Hyun, SA; Ka, M; Kim, HR; Ko, MY; Lee, BS; Lee, CY; Lee, YJ, 2020)
"Depression is the leading cause of mental health-related disease globally, and it affects an estimated 300 million people worldwide."1.51Antidepressant activity of crocin-I is associated with amelioration of neuroinflammation and attenuates oxidative damage induced by corticosterone in mice. ( Fu, Z; Shen, Q; Wang, L; Xiao, Q; Xie, X; Xiong, Z; Yu, C; Zhou, J, 2019)
" RESULTS The results showed that the extract at the dosage of 50 and 100 mg/kg significantly (p<0."1.51Antidepressive Effects of Taraxacum Officinale in a Mouse Model of Depression Are Due to Inhibition of Corticosterone Levels and Modulation of Mitogen-Activated Protein Kinase Phosphatase-1 (Mkp-1) and Brain-Derived Neurotrophic Factor (Bdnf) Expression. ( Duan, H; Gao, C; Guo, B; Kong, S; Li, D; Liang, X, 2019)
"Treatment with crocin, exposure to wheel running activity, and the combined interventions alleviated both behavioral and morphological deficits induced by adolescent stress."1.51Beneficial Effects of Physical Activity and Crocin Against Adolescent Stress Induced Anxiety or Depressive-Like Symptoms and Dendritic Morphology Remodeling in Prefrontal Cortex in Adult Male Rats. ( Ghalandari-Shamami, M; Nourizade, S; Pakdel, R; Rashidy-Pour, A; Vafaei, AA; Yousefi, B, 2019)
"Depression is a common psychiatric disease which pharmacological treatment relieves symptoms, but still far from ideal."1.51Tactile Stimulation on Adulthood Modifies the HPA Axis, Neurotrophic Factors, and GFAP Signaling Reverting Depression-Like Behavior in Female Rats. ( Burger, ME; de David Antoniazzi, CT; Duarte, MM; Duarte, T; Kronbauer, M; Milanesi, LH; Rosa, HZ; Rossato, DR; Roversi, K, 2019)
"Depression is a neuropsychiatry medical condition with high prevalence, in which the hypothalamic-pituitary-adrenal axis dysfunction has been postulated as the main cause."1.51Lutein prevents corticosterone-induced depressive-like behavior in mice with the involvement of antioxidant and neuroprotective activities. ( Camargo, A; Dalmagro, AP; Zeni, ALB, 2019)
"Corticosterone (CORT) has long been shown to modulate 5-HT system, and to alter hippocampal functions in various physiological and pathological conditions."1.51Acute corticosterone treatment elicits antidepressant-like actions on the hippocampal 5-HT and the immobility phenotype. ( He, T; Li, L; Li, X; Li, Y; Liang, Y; Ou, F; Sun, X; Tang, M; Wang, W; Zhang, X; Zhao, S; Zu, Y, 2019)
"Insomnia, depression, and Alzheimer's disease are all neurodegenerative diseases and are associated with the levels of steroid hormones."1.51The internal link of serum steroid hormones levels in insomnia, depression, and Alzheimer's disease rats: Is there an effective way to distinguish among these three diseases based on potential biomarkers? ( Bi, K; Li, Q; Liu, R; Wang, Z; Xu, H; Yang, X; Zhang, Q, 2019)
"Quercetin treatment was found to significantly reduce anxiety-like behaviors in mTBI-induced mice."1.51Quercetin mitigates anxiety-like behavior and normalizes hypothalamus-pituitary-adrenal axis function in a mouse model of mild traumatic brain injury. ( Ghorbanihaghjo, A; Kosari-Nasab, M; Mesgari-Abbasi, M; Salari, AA; Shokouhi, G, 2019)
"Corticosterone treatment altered all parameters in behavioral tests, leading to a depressive- and anxious-like behavior."1.51Reversal effect of Riparin IV in depression and anxiety caused by corticosterone chronic administration in mice. ( Barbosa Filho, JM; Capibaribe, VCC; Chaves, RC; da Silva, DMA; de Carvalho, AMR; de Sousa, FCF; Gutierrez, SJC; Lopes, IS; Macêdo, DS; Mallmann, ASV; Oliveira, ICM; Oliveira, NF; Valentim, JT; Vasconcelos, SMM, 2019)
"However, therapeutic treatments for depression or research on depression is scarce."1.51A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice. ( Kim, HJ; Lee, DK; Son, H; Yang, JH, 2019)
" We also examined whether Roman chamomile combined with clomipramine treatment affects hippocampal neurogenesis and serum corticosterone levels."1.51Roman chamomile inhalation combined with clomipramine treatment improves treatment-resistant depression-like behavior in mice. ( Hashikawa, N; Hashikawa-Hobara, N; Ishikawa, R; Otsuka, A, 2019)
"Depression is commonly associated with hypothalamic-pituitary adrenal (HPA) axis dysfunction that primarily manifests as aberrant glucocorticoid secretion."1.48Differential effects of imipramine and CORT118335 (Glucocorticoid receptor modulator/mineralocorticoid receptor antagonist) on brain-endocrine stress responses and depression-like behavior in female rats. ( Balmer, NJ; Caldwell, JL; Estrada, CM; Ghisays, V; Nguyen, ET; Solomon, MB; Streicher, J, 2018)
"Oxytocin (OXT) has been considered as a neuroregulator mediating social behaviors and stress-related disorders."1.48Injection of oxytocin into paraventricular nucleus reverses depressive-like behaviors in the postpartum depression rat model. ( Li, H; Li, X; Liu, B; Shi, C; Wang, H; Wang, T; Wang, Y; Wu, Y; Xu, ZD; Yang, Y; Zhang, P, 2018)
"Baicalin treatment inhibited APPL2/GR signaling pathway and improved neurogenesis at SVZ, OB, and hippocampus in APPL2 Tg mice and chronic corticosterone-induced depression mouse model."1.48Baicalin Modulates APPL2/Glucocorticoid Receptor Signaling Cascade, Promotes Neurogenesis, and Attenuates Emotional and Olfactory Dysfunctions in Chronic Corticosterone-Induced Depression. ( Deng, R; Du, Q; Gao, C; Li, W; Shen, J; Wang, Q; Xu, A, 2018)
"Depression is one of the most frequent neuropsychiatric diseases in the western world and its physiological causes are not yet fully understood."1.48Cholecalciferol counteracts depressive-like behavior and oxidative stress induced by repeated corticosterone treatment in mice. ( Camargo, A; da Silva, EB; Dalmagro, AP; Rikel, L; Simão da Silva, KAB; Zeni, ALB, 2018)
"Agmatine is a neuromodulator that has been proposed as a therapeutic strategy for the treatment of major depressive disorder (MDD)."1.48Single administration of agmatine reverses the depressive-like behavior induced by corticosterone in mice: Comparison with ketamine and fluoxetine. ( Bettio, LB; Fraga, DB; Freitas, AE; Gonçalves, FM; Heinrich, IA; Leal, RB; Lopes, MW; Moretti, M; Neis, VB; Olescowicz, G; Rodrigues, ALS; Rosa, PB, 2018)
"Corticosterone pre-treatment generated oxidative stress, altering antioxidant enzymes in the nervous tissue."1.48Antioxidant and antidepressant-like effects of Eugenia catharinensis D. Legrand in an animal model of depression induced by corticosterone. ( Alberton, MD; Barauna, SC; Brueckheimer, MB; de Albuquerque, CAC; de Gasper, AL; de Melo, DFM; Delwing-Dal Magro, D; Delwing-De Lima, D; Döhler, AW; Harger, MC; Maia, TP; Micke, GA; Sala, GABN; Siebert, DA, 2018)
"Thus, mechanical hyperalgesia and allodynia, and the pattern of c-Fos staining in the amygdala subnuclei were evaluated in rats with chronic constriction of the sciatic nerve, as well as sham-operated and naïve rats."1.48The critical role of amygdala subnuclei in nociceptive and depressive-like behaviors in peripheral neuropathy. ( Antunes, GF; Assis, DV; Gouveia, F; Kuroki, M; Martinez, RCR; Oliveira, CC; Pagano, RL; Santos, LCT; Seno, MDJ, 2018)
" Our study suggests that the exposure to PAS during an emotional challenge decreases despair-like behavior in rodents that were previously housed in an enriched environment in combination with auditory stimuli."1.48Exposure to Patterned Auditory Stimuli during Acute Stress Prevents Despair-Like Behavior in Adult Mice That Were Previously Housed in an Enriched Environment in Combination with Auditory Stimuli. ( Cabrera-Muñoz, EA; Flores-Gutiérrez, E; Ortiz-López, L; Ramírez-Rodríguez, GB; Vega-Rivera, NM, 2018)
"Insulin resistance has been identified as the key mechanism linking depression and diabetes."1.46Curcumin reverses the depressive-like behavior and insulin resistance induced by chronic mild stress. ( Li, YC; Li, YJ; Qiao, JY; Shen, JD; Wei, Y, 2017)
"Depression is a recurrent neuropsychiatric disorder that affects millions of individuals worldwide and impact negatively on the patients' social functions and quality of life."1.46Methyl jasmonate attenuated lipopolysaccharide-induced depressive-like behaviour in mice. ( Adebesin, A; Adeoluwa, OA; Eduviere, AT; Umukoro, S, 2017)
"Recently, depression has been envisioned as more than an alteration in neurotransmitters centered around receptor signaling pathways."1.46Fluoxetine coupled with zinc in a chronic mild stress model of depression: Providing a reservoir for optimum zinc signaling and neuronal remodeling. ( Omar, NN; Tash, RF, 2017)
"Depression is one of the important world-wide health problems."1.46Can Ocimum basilicum relieve chronic unpredictable mild stress-induced depression in mice? ( Ali, S; Ayuob, NN; El-Mansy, AA; Firgany, AEL, 2017)
"Comorbid depression was induced by five inescapable foot-shocks (2mA, 2ms duration) at 10s intervals on days 1, 5, 7, and 10."1.46Metformin and ascorbic acid combination therapy ameliorates type 2 diabetes mellitus and comorbid depression in rats. ( Kumar, M; Nayak, PK; Shivavedi, N; Tej, GNVC, 2017)
"Depression has become a common public health problem that is showing increasing prevalence."1.46Evaluation of the antidepressant-like effect of musk in an animal model of depression: how it works. ( Ayuob, NN, 2017)
"Etazolate (ETZ) is a new generation PDE4 inhibitor with encouraging safety and tolerance profiles."1.46Molecular modifications by regulating cAMP signaling and oxidant-antioxidant defence mechanisms, produce antidepressant-like effect: A possible mechanism of etazolate aftermaths of impact accelerated traumatic brain injury in rat model. ( Bhatt, S; Jindal, A; Mahesh, R; Pandey, D, 2017)
" A dose-response study showed that 4 weeks of CORT exposure at 35 μg/ml in the drinking water enhanced the emotionality score of female mice, but with a very small size effect."1.46Chronic corticosterone administration effects on behavioral emotionality in female c57bl6 mice. ( David, DJ; Gardier, AM; Guilloux, JP; Mekiri, M, 2017)
"Major depression is a multifactorial disease, involving both environmental and genetic risk factors."1.43SLC6A15, a novel stress vulnerability candidate, modulates anxiety and depressive-like behavior: involvement of the glutamatergic system. ( Balsevich, G; Chen, A; Dournes, C; Hartmann, J; Holsboer, F; Labermaier, C; Masana, M; Müller, MB; Santarelli, S; Schmidt, MV; Uribe, A; Wagner, KV, 2016)
"Treatment with berberine prevented these changes above."1.43Berberine up-regulates the BDNF expression in hippocampus and attenuates corticosterone-induced depressive-like behavior in mice. ( Fang, XY; Hu, CY; Jin, SL; Li, YC; Ma, LG; Pei, YY; Shen, JD, 2016)
"Depression is associated with hypothalamic-pituitary-adrenal (HPA) axis hyperactivity and testosterone exerts suppressive effects on the HPA axis."1.43Testosterone has antidepressant-like efficacy and facilitates imipramine-induced neuroplasticity in male rats exposed to chronic unpredictable stress. ( Chow, C; Galea, LA; Hamson, DK; Lieblich, SE; Tehrani, A; Wainwright, SR; Workman, JL, 2016)
"Depression is a common psychopathological disorders."1.43Zinc and imipramine reverse the depression-like behavior in mice induced by chronic restraint stress. ( Ding, Q; Huang, J; Li, H; Mo, F; Shen, H; Shen, Z; Tian, X; Wang, X, 2016)
"Depression was evaluated in all experimental groups using tail suspension and forced swim test on days 1, 5, 10 and 15, 2h after pentylenetetrazole challenge."1.43Adjuvant indoleamine 2,3-dioxygenase enzyme inhibition for comprehensive management of epilepsy and comorbid depression. ( Goel, RK; Singh, T, 2016)
" Furthermore, acute treatment of NPFFR2 agonists in wild-type (WT) mice enhanced the activity of the HPA axis, and chronic administration resulted in depressive and anxiety-like behaviors."1.43Chronic activation of NPFFR2 stimulates the stress-related depressive behaviors through HPA axis modulation. ( Chang, CC; Chen, JC; Chen, TC; Day, YJ; Huang, GJ; Lin, YT; Liu, TY; Yang, CY; Yu, YL, 2016)
"Depression is a heterogeneous disorder characterized by alterations at psychological, behavioural, physiological, neurophysiological, and neurochemical levels."1.43Simultaneous Changes in Sleep, qEEG, Physiology, Behaviour and Neurochemistry in Rats Exposed to Repeated Social Defeat Stress. ( Ahnaou, A; Drinkenburg, WH, 2016)
"Pneumococcal meningitis is a life-threatening infection of the central nervous system (CNS) with a high mortality rate."1.43Depression-Like Adult Behaviors may be a Long-Term Result of Experimental Pneumococcal Meningitis in Wistar Rats Infants. ( Barichello, T; Dominguini, D; Generoso, JS; Jornada, LK; Quevedo, J; Sharin, VS; Simões, LR; Souza, LB; Teixeira, AL; Valvassori, SS, 2016)
"Musk has an antidepressant-like effect in an animal model of depression, so it is advisable to assess its efficacy in people continually exposed to stressors."1.43The antidepressant effect of musk in an animal model of depression: a histopathological study. ( Ahmed, SM; Ali, SS; Ayuob, NN; El Wahab, MGA; Suliaman, M, 2016)
"We demonstrate that depression is associated with decreased gut microbiota richness and diversity."1.43Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat. ( Beers, S; Borre, Y; Clarke, G; Cryan, JF; Deane, J; Dinan, TG; El Aidy, S; Fitzgerald, P; Hoban, AE; Kelly, JR; Kennedy, PJ; Moloney, G; O' Brien, C; Patterson, E; Ross, P; Scott, K; Scott, L; Stanton, C, 2016)
"Major depression is a life threatening neuropsychiatric disorder that produces mental illness and major cause of morbidity."1.43Neuroprotective, Neurotrophic and Anti-oxidative Role of Bacopa monnieri on CUS Induced Model of Depression in Rat. ( Kumar, S; Mondal, AC, 2016)
" Chronic administration of BB effectively reversed these alterations."1.43Bilobalide alleviates depression-like behavior and cognitive deficit induced by chronic unpredictable mild stress in mice. ( Shui, L; Song, Z; Tai, F; Wang, S; Wu, R, 2016)
" Rearing in social isolation increased stress reactivity in comparison to both controls and in combination with periodic maternal separation, without affecting the coping strategy associated with the forced swimming test."1.43Early Life Stress Increases Metabolic Risk, HPA Axis Reactivity, and Depressive-Like Behavior When Combined with Postweaning Social Isolation in Rats. ( Gomez, C; Junco, M; Lajud, N; Vargas, J, 2016)
"Indeed, here we found that cardiac hypertrophy and heart failure induced by TAC were associated with depression-like behaviors concomitant with downregulation of σ1R expression in brain 6 weeks after surgery."1.43Corticosteroids Mediate Heart Failure-Induced Depression through Reduced σ1-Receptor Expression. ( Bhuiyan, MS; Fukunaga, K; Han, F; Hasegawa, H; Kanai, H; Shinoda, Y; Tagashira, H; Zhang, C, 2016)
"Depression is the most common form of mental disability in the world."1.43Anhedonia but not passive floating is an indicator of depressive-like behavior in two chronic stress paradigms. ( Freiman, SV; Gulyaeva, NV; Lazareva, NA; Levchenko, OA; Levshina, IP; Novikova, MR; Onufriev, MV; Stepanichev, MY; Tishkina, AO, 2016)
"Corticosterone levels were significantly increased compared to control values (p<0."1.43Chronic unpredictable mild stress paradigm in male Wistar rats: effect on anxiety- and depressive-like behavior. ( Belovičová, K; Bögi, E; Koprdova, R; Mach, M; Okuliarová, M; Sedláčková, N; Ujházy, E, 2016)
"Depression is a common psychiatric disorder associated with chronic stress."1.42Insulin-like growth factor 2 mitigates depressive behavior in a rat model of chronic stress. ( Cao, WY; Dai, RP; Duan, J; Hu, ZL; Li, CQ; Li, F; Luo, YW; Wang, XQ; Xu, Y; Zhang, JY; Zhong, XL; Zhou, M, 2015)
" Repeated CORT dosing caused depression-like behavior in mice as indicated by increased despair effects in forced swim test (FST) and anhedonia in sucrose preference test."1.42Effect of a novel 5-HT3 receptor antagonist 4i, in corticosterone-induced depression-like behavior and oxidative stress in mice. ( Gupta, D; Kurhe, Y; Radhakrishnan, M, 2015)
"The range of defects that fall within fetal alcohol spectrum disorder (FASD) includes persistent behavioral problems, with anxiety and depression being two of the more commonly reported issues."1.42Hypothalamic-pituitary-adrenal axis and behavioral dysfunction following early binge-like prenatal alcohol exposure in mice. ( Fish, EW; O'Leary-Moore, SK; Parnell, SE; Sulik, KK; Wieczorek, L, 2015)
"Post-traumatic stress disorder (PTSD) is a stress-related mental disorder caused by traumatic experiences."1.42Long-term effects of early adolescent stress: dysregulation of hypothalamic-pituitary-adrenal axis and central corticotropin releasing factor receptor 1 expression in adult male rats. ( Jiang, H; Li, C; Liu, D; Liu, Y; Lu, C; Pan, F; Yin, S, 2015)
"Chronic pain and depression are two complex states that often coexist in the clinical setting and traditional antidepressants and analgesics have shown limited clinical efficacy."1.42m-Trifluoromethyl-diphenyl diselenide, a multi-target selenium compound, prevented mechanical allodynia and depressive-like behavior in a mouse comorbid pain and depression model. ( Brüning, CA; Duarte, MM; Gai, BM; Martini, F; Nogueira, CW; Sampaio, TB; Soares, SM, 2015)
" Chronic administration of lithium chloride or valproic acid, two clinically effective mood stabilizers, reverses the majority of these behavioral abnormalities."1.42Mice heterozygous for cathepsin D deficiency exhibit mania-related behavior and stress-induced depression. ( Duan, S; Han, Y; Li, X; Lou, H; Lu, Y; Zhen, X; Zhou, R; Zhu, L, 2015)
"Corticosterone levels were increased in the untreated STZ group; SMV and clomipramine significantly decreased corticosterone levels in the STZ groups, but had no effect on the CTR groups."1.42Antidepressant-like effect of simvastatin in diabetic rats. ( ElBatsh, MM, 2015)
"Rats treated with sanggenon G also exhibited a decrease in the limbic hypothalamic-pituitary-adrenal (HPA) axis response to the FST, as indicated by attenuation of the corticosterone response and decreased c-Fos immunoreactivity in the hypothalamic paraventricular nucleus (PVN)."1.42Antidepressant-Like Effects of Sanggenon G, Isolated from the Root Bark of Morus alba, in Rats: Involvement of the Serotonergic System. ( Baek, NI; Han, D; Jung, JW; Kim, IH; Kim, YT; Lim, DW; Park, JH, 2015)
"Plumbagin has been reported to be neuroprotective, so it might possess antidepressant activity."1.42Antidepressant-like activity of plumbagin in unstressed and stressed mice. ( Bansal, S; Dhingra, D, 2015)
"Myricetin treatment improved activities of glutathione peroxidase (GSH-PX) in the hippocampus of stressed mice."1.42Myricetin Attenuates Depressant-Like Behavior in Mice Subjected to Repeated Restraint Stress. ( Cui, L; Ma, Z; Wang, G; Wang, Q, 2015)
"Anxiety and depression are common in diabetics."1.40Anxiety- and depression-like behavior are correlated with leptin and leptin receptor expression in prefrontal cortex of streptozotocin-induced diabetic rats. ( Agilkaya, S; Aksu, I; Ates, M; Baykara, B; Buyuk, E; Cetinkaya, C; Cingoz, S; Dayi, A; Kiray, M; Sisman, AR; Uysal, N, 2014)
"These findings highlight how genetic predisposition shapes individuals' response to early life stress."1.40High novelty-seeking rats are resilient to negative physiological effects of the early life stress. ( Akil, H; Clinton, SM; Watson, SJ, 2014)
"Corticosterone was quantified in 11-week-old mice."1.40Maternal separation modifies behavioural and neuroendocrine responses to stress in CCR7 deficient mice. ( Baune, BT; Corrigan, F; Harrison, EL; Jaehne, EJ; Jawahar, MC, 2014)
"Depression is generally a recurrent psychiatric disorder."1.40A neuroendocrine mechanism of co-morbidity of depression-like behavior and myocardial injury in rats. ( Baoying, J; Lei, W; Lingjia, Q; Rui, Z; Wei, L; Xinxing, W, 2014)
"Depression is a serious mental disorder in the world, but the underlying mechanisms remain unclear and the effective cures are scarce."1.40Iptakalim confers an antidepressant effect in a chronic mild stress model of depression through regulating neuro-inflammation and neurogenesis. ( Ding, JH; Geng, F; Hu, G; Lu, M; Yang, JZ, 2014)
" Clinical investigations revealed that long-term use of statins appeared to be associated with a lower risk of anxiety and depression."1.40Simvastatin treatment exerts antidepressant-like effect in rats exposed to chronic mild stress. ( Chang, AY; Lin, PY; Lin, TK, 2014)
"Treatment with emodin normalized the change of plasma corticosterone level, which demonstrated that emodin could partially restore CUMS-induced HPA axis impairments."1.40Emodin opposes chronic unpredictable mild stress induced depressive-like behavior in mice by upregulating the levels of hippocampal glucocorticoid receptor and brain-derived neurotrophic factor. ( Fu, Q; Li, M; Li, S; Li, Y; Ma, S; Xue, J, 2014)
"Patients suffering from neuropathic pain have a higher incidence of mood disorders such as depression."1.40Neuropathic pain-induced depressive-like behavior and hippocampal neurogenesis and plasticity are dependent on TNFR1 signaling. ( Bernardes, D; Bethea, JR; Brambilla, R; Dellarole, A; Grilli, M; Morton, P; Summers, S; Walters, W, 2014)
"The corticosterone-treated rats showed significantly reduced sleep time, disinhibition of rapid-eye-movement (REM) sleep and altered power spectra during non-REM sleep."1.40Correlations between depression behaviors and sleep parameters after repeated corticosterone injections in rats. ( Cao, Q; Cui, SY; Cui, XY; Huang, YL; Li, SJ; Sheng, ZF; Wang, ZJ; Yu, B; Zhang, XQ; Zhang, YH, 2014)
" Additionally, the effects of chronic administration of the tricyclic antidepressant imipramine and the anti-TNF-α pentoxyphylline were investigated."1.40Lipopolysaccharide repeated challenge followed by chronic mild stress protocol introduces a combined model of depression in rats: reversibility by imipramine and pentoxifylline. ( Abd-Alkhalek, HA; Abdel-tawab, AM; Aboul-Fotouh, S; El Tabbal, M; Elgarf, AS; Farrag, KA; Hammouda, GA; Hassan, AN; Kassim, SK, 2014)
"Corticosterone treatment induced longer immobility times in the FST, reflecting depressive-like behaviour."1.40Long-term corticosterone exposure decreases insulin sensitivity and induces depressive-like behaviour in the C57BL/6NCrl mouse. ( Blokland, A; Cañete, R; Pawluski, JL; Sierksma, AS; Steinbusch, HW; Vaessen, KR; van Donkelaar, EL, 2014)
"Corticosterone treatment caused a depressive-like behavior, evidenced by increased immobility time in the tail suspension test and decreased time in which mice spent grooming in the splash test."1.40Folic acid prevents depressive-like behavior induced by chronic corticosterone treatment in mice. ( Bettio, LE; Colla, A; Lieberknecht, V; Moretti, M; Ribeiro, CM; Rodrigues, AL; Rosa, PB, 2014)
"Honokiol (HNK) is a biphenolic neolignan possessing multiple biological activities including antioxidant, anti-inflammatory, anxiolytic, antidepressant and neuroprotective."1.40Honokiol abrogates lipopolysaccharide-induced depressive like behavior by impeding neuroinflammation and oxido-nitrosative stress in mice. ( Baruah, CC; Dwivedi, S; Hazarika, NK; Jangra, A; Kumar, P; Lahkar, M; Sulakhiya, K, 2014)
"Depression has been considered to be both a symptom and risk factor of AD."1.39Effects of corticosterone and amyloid-beta on proteins essential for synaptic function: implications for depression and Alzheimer's disease. ( Chang, RC; Cheng, SS; Ho, YS; Hung, CH; Law, AC; Wong, GT; Wuwongse, S; Zhang, NQ, 2013)
"Agmatine treatment also normalized the elevated corticosterone levels and prevented the body weight changes in chronically stressed animals."1.39Agmatine attenuates chronic unpredictable mild stress induced behavioral alteration in mice. ( Aglawe, MM; Dixit, MP; Faldu, DS; Kotagale, NR; Sakaria, JN; Taksande, BG; Umekar, MJ, 2013)
"Treatment with baicalin (10, 20, 40 mg/kg) prevented these abnormalities induced by CMS."1.39Chronic treatment with baicalin prevents the chronic mild stress-induced depressive-like behavior: involving the inhibition of cyclooxygenase-2 in rat brain. ( Jiao, S; Li, J; Li, YC; Shen, JD; Wang, R; Yi, LT, 2013)
"Coenzyme Q10 (CoQ10) is an essential cofactor in the mitochondrial electron transport pathway and has a powerful antioxidant capacity."1.39Coenzyme Q10 displays antidepressant-like activity with reduction of hippocampal oxidative/nitrosative DNA damage in chronically stressed rats. ( Aboul-Fotouh, S, 2013)
"Anxiety and depression are considered as stress-related disorders, which present considerable sex differentiation."1.38Behavioral sexual dimorphism in models of anxiety and depression due to changes in HPA axis activity. ( Antoniou, K; Dalla, C; Dendi, A; Kokras, N; Mikail, HG; Papadopoulou-Daifoti, Z; Sideris, AC, 2012)
"Melancholic depression has typically been associated with HPA hyperactivity, while atypical depression has been linked with HPA hypoactivity."1.38Lack of elevations in glucocorticoids correlates with dysphoria-like behavior after repeated social defeat. ( Bhatnagar, S; Bowens, N; Heydendael, W; Jacobson, L, 2012)
"Piperine (1 μM) co-treatment also significantly decreased intracellular reactive oxygen species level, and enhanced superoxide dismutase activity and total glutathione level in corticosterone-treated PC12 cells."1.38Protective effects of piperine against corticosterone-induced neurotoxicity in PC12 cells. ( Che, CT; Huang, Z; Ip, SP; Mao, QQ; Xian, YF, 2012)
"Corticosterone induced an increase glutamate and a decrease in GABA release in hippocampal slices, which was reversed by venlafaxine."1.38Long lasting effects of early-life stress on glutamatergic/GABAergic circuitry in the rat hippocampus. ( Horrillo, I; Martisova, E; Meana, JJ; Ortega, JE; Ramírez, MJ; Solas, M; Tordera, RM, 2012)
"Depression is a debilitating mental illness and is often comorbid with metabolic disorders such as type 2 diabetes."1.38Adiponectin is critical in determining susceptibility to depressive behaviors and has antidepressant-like activity. ( Cheng, SY; Ding, J; Guo, M; Liu, F; Liu, J; Liu, M; Lu, XY; Scherer, PE; Zhang, D, 2012)
"Chronic pain and depression are two complex states with sensory/somatic and emotional components, and they may mutually exacerbate one another in conditions of comorbidity, leading to a poorer prognosis."1.38Depressive-like states heighten the aversion to painful stimuli in a rat model of comorbid chronic pain and depression. ( Berrocoso, E; Bravo, L; Leza, JC; Mico, JA; Pérez-Nievas, B; Rey-Brea, R, 2012)
"Depression is a life-threatening psychiatric disorder characterized with a long-term hypercortisolemia in depressed patients."1.38Synaptic plasticity, but not hippocampal neurogenesis, mediated the counteractive effect of wolfberry on depression in rats(1). ( Chang, RC; Lau, BW; Lee, TM; Ma, H; So, KF; Yau, SY; Zhang, E, 2012)
"Depression is a major psychiatric disorder affecting nearly 21% of the world population and imposes a substantial health burden on society."1.37Protective effects of flavonoid extract from Apocynum venetum leaves against corticosterone-induced neurotoxicity in PC12 cells. ( Liu, C; Ma, F; Pan, F; Shi, D; Zhang, Y; Zheng, M, 2011)
"Icariin is a major constituent of flavonoids isolated from the herb Epimedium."1.37Icariin attenuates social defeat-induced down-regulation of glucocorticoid receptor in mice. ( Dong, J; Du, J; Le, J; Liu, B; Wu, J; Xu, C; Xu, Y, 2011)
"Major depression is an independent risk factor for the development of cardiovascular disease."1.37Altered aortic vascular reactivity in the unpredictable chronic mild stress model of depression in mice: UCMS causes relaxation impairment to ACh. ( Belzung, C; Camus, V; d'Audiffret, A; Freslon, JL; Frisbee, J; Isingrini, E; O'Donnell, J; Surget, A, 2011)
"Depression is a stress related disease, as hormones of the stress-axis can modify mood."1.37Do stress hormones connect environmental effects with behavior in the forced swim test? ( Domokos, Á; Mergl, Z; Mikics, É; Pintér, O; Zelena, D, 2011)
"Luteolin is a flavonoid contained in many plants and with a variety of known pharmacological properties such as anti-inflammatory, anti-anxiety, and memory-improving effects, suggesting that luteolin penetrates into the brain."1.37Luteolin shows an antidepressant-like effect via suppressing endoplasmic reticulum stress. ( Hara, H; Ishisaka, M; Kakefuda, K; Shimazawa, M; Tsuruma, K; Tsuruta, A; Yamauchi, M, 2011)
" This study was aimed to assess the anxiolytic and antidepressant-like properties of tiagabine, an inhibitor of the GABA transporter-1 (GAT-1), after acute and chronic administration in C57BL/6JOlaHsD mice with paroxetine as a positive control."1.36Long-term anxiolytic and antidepressant-like behavioural effects of tiagabine, a selective GABA transporter-1 (GAT-1) inhibitor, coincide with a decrease in HPA system activity in C57BL/6 mice. ( Erhardt, A; Holsboer, F; Keck, ME; Mueller, MB; Ohl, F; Sillaber, I; Thoeringer, CK, 2010)
"The treatment with imipramine reversed all the parameters described above."1.36Depressive-like parameters in sepsis survivor rats. ( Barichello, T; Cassol, OJ; Comim, CM; Constantino, LC; Constantino, LS; Dal-Pizzol, F; Kapczinski, F; Petronilho, F; Quevedo, J; Stertz, L, 2010)
"Treatment with mifepristone decreased immobility and increased swimming (but not climbing) behavior in the FST, consistent with anti-depressant action."1.36Mifepristone decreases depression-like behavior and modulates neuroendocrine and central hypothalamic-pituitary-adrenocortical axis responsiveness to stress. ( Herman, JP; Solomon, MB; Wulsin, AC, 2010)
"Sepsis is characterized by a systemic inflammatory response of the immune system against an infection, presenting with hypothalamic-pituitary-adrenal (HPA) axis dysfunction, behavior alterations, and high mortality."1.36Low dose dexamethasone reverses depressive-like parameters and memory impairment in rats submitted to sepsis. ( Cassol, OJ; Comim, CM; Constantino, LS; Dal-Pizzol, F; Petronilho, F; Quevedo, J; Streck, EL, 2010)
"In the long run, insufficient sleep may have repercussions for health and may sensitize individuals to psychiatric diseases."1.35Chronically restricted sleep leads to depression-like changes in neurotransmitter receptor sensitivity and neuroendocrine stress reactivity in rats. ( Cetin, T; den Boer, JA; Hagewoud, R; Luiten, PG; Meerlo, P; Novati, A; Roman, V, 2008)
"Melatonin is a hormone primarily synthesized by the pineal gland and has been shown to govern seasonal and circadian rhythms, as well as the immune system, certain behaviours, and responses to stress."1.35Antidepressant-like effects of melatonin in the mouse chronic mild stress model. ( Caumo, W; Detanico, BC; Elisabetsky, E; Freitas, JJ; Hidalgo, MP; Lhullier, FL; Piato, AL, 2009)
"Depression is frequently reported in epilepsy patients; however, mechanisms of co-morbidity between epilepsy and depression are poorly understood."1.35Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy. ( Bragin, A; Kwon, YS; Mazarati, AM; Pineda, E; Sankar, R; Shin, D; Taylor, AN; Tio, D, 2009)
"Treatment with desipramine (20mg/kg, i."1.35Increased water temperature renders single-housed C57BL/6J mice susceptible to antidepressant treatment in the forced swim test. ( Bächli, H; Habersetzer, U; Steiner, MA; Wotjak, CT, 2008)
" The latter effect could be mimicked in C57BL/6N mice by acute, subchronic, and chronic administration of the selective CB1 antagonist SR141716."1.35Antidepressant-like behavioral effects of impaired cannabinoid receptor type 1 signaling coincide with exaggerated corticosterone secretion in mice. ( Holsboer, F; Lutz, B; Marsicano, G; Nestler, EJ; Steiner, MA; Wotjak, CT, 2008)
"We have reported that neonatal bacterial infection in rats leads to exaggerated brain cytokine production, as well as memory impairments, to a subsequent peripheral immune challenge in adulthood, and therefore predicted that stressor-induced depressive-like symptoms would be more severe in these rats as well."1.35Bacterial infection early in life protects against stressor-induced depressive-like symptoms in adult rats. ( Amat, J; Bilbo, SD; Maier, SF; Paul, ED; Watkins, LR; Yirmiya, R, 2008)
" Daily administration of onion powder at a dosage of 50 mg/kg of body weight/day for 14 days significantly reduced the immobility time in FST without changing the motor dysfunction, indicating that the daily consumption of onion exerted antidepressant-like activity."1.35Antidepressant-like effect of onion (Allium cepa L.) powder in a rat behavioral model of depression. ( Kawai, Y; Sakakibara, H; Terao, J; Yoshino, S, 2008)
"Treatment with piperine (6."1.34Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanisms. ( Li, S; Li, W; Matsumoto, K; Tang, Y; Wang, C; Wang, M, 2007)
"Imipramine treatment offset all the behavioral and neurochemical stress-induced modifications."1.34Hypothalamus-pituitary-adrenal modifications consequent to chronic stress exposure in an experimental model of depression in rats. ( Cassanelli, A; Danielli, B; De Montis, MG; Raone, A; Rauggi, R; Scheggi, S, 2007)
"Phenelzine did not increase paraventricular hypothalamus CRH or vasopressin mRNA in ADX mice lacking corticosterone replacement."1.33Chronic treatment with the monoamine oxidase inhibitor phenelzine increases hypothalamic-pituitary-adrenocortical activity in male C57BL/6 mice: relevance to atypical depression. ( Han, J; Jacobson, L; Kier, A, 2005)
" E(2), 10 mug, compared to vehicle or 50 mug, reduced anxiety and depressive behavior of sham and adrenalectomized rats administered the low dosage of corticosterone, but not vehicle or the high dosage of corticosterone, suggesting that there may be an optimal level of corticosterone necessary for E(2) to exert these effects."1.33Antianxiety and antidepressive behavior produced by physiological estradiol regimen may be modulated by hypothalamic-pituitary-adrenal axis activity. ( Frye, CA; Walf, AA, 2005)
"Electroconvulsive seizure (ECS)-treatment, an animal model for the antidepressant treatment electroconvulsive therapy, can enhance proliferation of glial cells."1.33Corticosterone-induced inhibition of gliogenesis in rat hippocampus is counteracted by electroconvulsive seizures. ( Ekstrand, J; Hellsten, J; Lindgren, H; Tingström, A; Wennström, M, 2006)
"Since depression is a multifaceted disorder, and a number of symptoms may be present, including circadian rhythm disturbances, we attempted to find the chronobiological abnormalities in CMS rats."1.33Chronobiological disturbances with hyperthermia and hypercortisolism induced by chronic mild stress in rats. ( Higuchi, S; Morikawa, T; Ohdo, S; To, H; Ushijima, K, 2006)
"Anxiety and depression are currently classified as separate clinical syndromes despite considerable similarities in their symptoms, pathophysiological substrates and response to treatment interventions."1.33Modeling the anxiety-depression continuum hypothesis in domestic fowl chicks. ( Acevedo, EO; Cartwright, CM; Feltenstein, MW; Sufka, KJ; Warnick, JE; Webb, HE, 2006)
"Corticosterone treatment was found to induce a significant attenuation in the response to 8-OHDPAT, indicating functional desensitization of somatodendritic 5-HT(1A) autoreceptors."1.32Flattening the corticosterone rhythm attenuates 5-HT1A autoreceptor function in the rat: relevance for depression. ( Gartside, SE; Ingram, CD; Leitch, MM; McQuade, R; Young, AH, 2003)
"Corticosterone treatment decreased [3H] 8-hydroxy-2-(di-n-propylamino)tetralin binding to the 5-hydroxytryptamine1A receptor in the cortex but not in the hippocampus."1.32Implantation of a slow release corticosterone pellet induces long-term alterations in serotonergic neurochemistry in the rat brain. ( Bush, VL; Fone, KC; Marsden, CA; Middlemiss, DN, 2003)
"Depression is a multifactorial illness and genetic factors play a role in its etiology."1.32Behavioral, neurochemical, and electrophysiological characterization of a genetic mouse model of depression. ( Adrien, J; Bouali, S; Costentin, J; El Yacoubi, M; Hamon, M; Leroux-Nicollet, I; Naudon, L; Popa, D; Vaugeois, JM, 2003)
"Fluoxetine treatment also reversed the deficit in escape latency observed in animals exposed to IS."1.32Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment. ( Duman, RS; Malberg, JE, 2003)
"Melatonin has been demonstrated to increase activity in the forced swim test (FST), a putative model of antidepressant efficacy, indicating that it may possess antidepressant-like qualities."1.32Corticosterone attenuates the antidepressant-like effects elicited by melatonin in the forced swim test in both male and female rats. ( Brotto, LA; Gorzalka, BB; Hill, MN; Lee, TT, 2003)
"Corticosterone serum levels were elevated in both sexes."1.32Sex differences in behavioral, neurochemical and neuroendocrine effects induced by the forced swim test in rats. ( Antoniou, K; Dalla, C; Drossopoulou, G; Kitraki, E; Papadopoulou-Daifoti, Z; Papalexi, E; Papathanasiou, G, 2004)
"The body weight gain was reduced in males only."1.31Corticotropin-releasing hormone mRNA levels in response to chronic mild stress rise in male but not in female rats while tyrosine hydroxylase mRNA levels decrease in both sexes. ( Duncko, R; Jezová, D; Kiss, A; Rusnák, M; Skultétyová, I, 2001)

Research

Studies (863)

TimeframeStudies, this research(%)All Research%
pre-199020 (2.32)18.7374
1990's16 (1.85)18.2507
2000's114 (13.21)29.6817
2010's537 (62.22)24.3611
2020's176 (20.39)2.80

Authors

AuthorsStudies
Liu, W6
Wang, H9
Li, X10
Xu, Y8
Zhang, J6
Wang, W10
Gong, Q2
Qiu, X1
Zhu, J2
Mao, F1
Zhang, H7
Li, J16
Salgin-Goksen, U1
Telli, G1
Erikci, A1
Dedecengiz, E1
Tel, BC1
Kaynak, FB1
Yelekci, K1
Ucar, G1
Gokhan-Kelekci, N1
Yu, Z2
Li, D3
Zhai, S1
Xu, H3
Liu, H4
Ao, M1
Zhao, C1
Jin, W2
Yu, L1
Bai, G1
Qiao, Y1
Lo, PC1
Song, L5
Yang, Y9
Duan, L1
Wei, S2
Li, M6
Huang, S1
Zhang, B3
Wang, Q9
Yang, C1
Hong, C1
Chen, L5
Kong, W1
Zhang, D2
Wang, L3
Zhao, J4
Zhong, X1
Zhang, G1
Huang, Z5
Qiu, F1
Tang, Y2
Yang, J4
Ye, C1
Xu, X1
Cai, M2
Zhang, Y15
Lu, H1
Mo, F2
Li, H7
Shen, H3
Sakurai, K1
Itou, T1
Morita, M1
Kasahara, E1
Moriyama, T1
Macpherson, T1
Ozawa, T1
Miyamoto, Y1
Yoneda, Y1
Sekiyama, A1
Oka, M1
Hikida, T1
Gouveia, FV1
Germann, J1
Oliveira, CC2
Castro, MC1
Antunes, GF2
Gomes, GCV1
Pinto, TRC1
Martinez, RCR2
Valle, AC1
Oliveira, TQ1
Chaves Filho, AJM2
Jucá, PM2
Soares, MVR2
Cunha, NL1
Vieira, CFX1
Gadelha Filho, CVJ1
Viana, GA1
De Oliveira, GMF1
Macedo, DS6
Vasconcelos, SMM5
Flores-Burgess, A1
Millón, C1
Gago, B1
García-Durán, L1
Cantero-García, N1
Puigcerver, A1
Narváez, JA1
Fuxe, K1
Santín, L1
Díaz-Cabiale, Z1
Ngoupaye, GT3
Mokgokong, M1
Madlala, T1
Mabandla, MV1
Gao, ZY1
Chen, TY1
Yu, TT1
Zhang, LP1
Zhao, SJ1
Gu, XY1
Pan, Y2
Kong, LD1
Luo, Y1
Hou, X2
Lu, K1
He, Y1
Yang, B4
Qin, Y2
Veenit, V2
Zhang, X5
Ambrosini, A1
Sousa, V1
Svenningsson, P2
Chen, X3
Yang, T1
Zhang, C12
Ma, Z2
Aleksic, M1
Brkic, Z5
Petrovic, Z3
Francija, E2
Lukic, I2
Adzic, M5
Eskandari, F1
Salimi, M1
Hedayati, M1
Zardooz, H1
Xu, S1
Zhao, X2
Zhu, Z1
He, M2
Zheng, X1
Zhu, L3
Lu, S1
Bai, M1
Li, Y10
Xu, E1
Dos Santos, BM2
Pereira, GC3
Piton, E2
Fialho, MFP2
Becker, G1
da Silva Carlotto, M1
Camargo, LFM1
Ramanzini, LG1
Oliveira, SM1
Trevisan, G2
Zanchet, EM1
Pillat, MM1
Bochi, GV3
Ryan-Coats, SK1
Hughes, SD1
Holz, FM1
Kreger, RB1
Koulibali, CI1
Khan, HA1
Harris, KC1
Kelly, AE1
Epps, SA1
Naghibi, S1
Barzegari, A1
Shariatzadeh, M1
Vatandoust, M1
Ahmadi, M1
Mahdinia, E1
Neghabi, F1
Rajabpour, A1
Sadat Aleahmad, A1
Sadat Balaghati, F1
Sadat Naserimanesh, S1
Saeedipour, M1
Sadeghi, O1
Yeganeh, F1
Salari, AA14
Wang, Z10
Cheng, Y2
Lu, Y5
Sun, G2
Pei, L2
Allen, J4
Romay-Tallon, R5
Mitchell, MA2
Brymer, KJ3
Johnston, J2
Sánchez-Lafuente, CL2
Pinna, G2
Kalynchuk, LE12
Caruncho, HJ8
Moraga-Amaro, R1
Guerrin, CGJ1
Reali Nazario, L1
Lima Giacobbo, B1
J O Dierckx, RA1
Stehberg, J1
de Vries, EFJ1
Doorduin, J1
Zhao, H3
Jiang, M2
Miao, M1
Hu, YQ1
Niu, TT1
Xu, JM1
Peng, L2
Sun, QH1
Huang, Y3
Zhou, J6
Ding, YQ1
Ponce-Regalado, MD1
Salazar-Juárez, A1
Rojas-Espinosa, O1
Contis-Montes de Oca, A1
Hurtado-Alvarado, G1
Arce-Paredes, P1
Pérez-Sánchez, G1
Pavón, L1
Girón-Pérez, MI1
Hernández-Pando, R1
Alvarez-Sánchez, ME1
Becerril-Villanueva, E1
Rupasinghe, R1
Dezsi, G1
Ozturk, E1
Carron, S1
Hudson, MR1
Casillas-Espinosa, PM1
Jones, NC1
Farajdokht, F2
Oghbaei, F1
Sadigh-Eteghad, S2
Majdi, A1
Aghsan, SR1
Farhoudi, M1
Vahidi-Eyrisofla, N1
Mahmoudi, J2
Ramadan, B1
Cabeza, L1
Cramoisy, S1
Houdayer, C1
Andrieu, P1
Millot, JL1
Haffen, E1
Risold, PY1
Peterschmitt, Y1
Lim, DW5
Han, D4
Lee, C4
Yamauchi, T2
Yoshioka, T1
Yamada, D1
Hamano, T1
Ikeda, M1
Kamei, M1
Otsuki, T1
Sato, Y1
Nii, K1
Suzuki, M1
Iriyama, S1
Yoshizawa, K2
Nishino, S1
Ichikawa, H1
Miyazaki, S1
Saitoh, A1
Hirtz, R1
Libuda, L1
Hinney, A1
Föcker, M1
Bühlmeier, J1
Holterhus, PM1
Kulle, A1
Kiewert, C1
Hauffa, BP1
Hebebrand, J1
Grasemann, C1
Zhang, T1
Xie, X6
Gong, J1
Verma, H1
Shivavedi, N2
Tej, GNVC2
Kumar, M2
Nayak, PK2
Shi, LS1
Ji, CH1
Tang, WQ1
Liu, Y10
Zhang, W7
Guan, W1
Jin, H1
Zhou, Y6
Ye, J1
Qiu, C1
Mouri, A1
Lu, Q1
Kunisawa, K1
Kubota, H1
Hasegawa, M1
Hirakawa, M1
Mori, Y1
Libo, Z1
Saito, K1
Nabeshima, T1
Du, Y2
Shi, Y3
Wang, X7
Song, H2
Hao, Y2
Zhao, Y9
Guo, X3
Shi, M1
Gong, M2
Wang, S6
Gao, Y7
Shi, H4
Ebrahimian, F1
Najdi, N1
Masrour, FF1
Breviario, S1
Senserrich, J1
Florensa-Zanuy, E3
Garro-Martínez, E4
Díaz, Á4
Castro, E4
Pazos, Á5
Pilar-Cuéllar, F5
Fan, X1
Deng, H2
Qiu, J2
Ji, H1
Shen, X1
Helmy, H1
Hamid Sadik, NA1
Badawy, L1
Sayed, NH1
Chen, Y6
Cai, W1
Li, C5
Su, Z1
Guo, Z1
Li, Z4
Wang, C6
Xu, F1
Jiang, C1
Qi, J1
He, Q1
Song, N2
Yao, H1
Jiang, S2
Wang, Y6
Zheng, Y2
Ding, J4
Hu, G6
Lu, M3
Chen, J6
Zhu, W3
Zeng, X1
Yang, K1
Peng, H1
Hu, L1
He, J1
Wei, J2
Chu, S1
Zhang, Z2
He, F1
Wei, D1
Xie, J1
Lai, K1
Chen, N1
Wei, G1
Jung, JTK1
Marques, LS1
Zborowski, VA1
Silva, GL1
Nogueira, CW3
Zeni, G2
Gupta, GL1
Sharma, L1
Sharma, M1
Hales, CA1
Stuart, SA1
Griffiths, J1
Bartlett, J1
Arban, R1
Hengerer, B1
Robinson, ES1
Baghaei Naeini, F1
Hassanpour, S1
Asghari, A1
Huang, HS1
Lin, YE3
Panyod, S3
Chen, RA1
Lin, YC1
Chai, LMX1
Hsu, CC3
Wu, WK1
Lu, KH2
Huang, YJ1
Sheen, LY3
Liu, BP3
Zhang, YP3
Li, KW3
Song, C7
Huang, C4
Zhang, F5
Li, P3
Acevedo, J2
Mugarura, NE2
Welter, AL2
Johnson, EM2
Siegel, JA3
Motafeghi, F2
Bagheri, A2
Seyedabadi, M2
Shaki, F2
Shokrzadeh, M2
Wang, XL1
Miao, C1
Su, Y1
Meng, X2
Sharma, A1
Singh, T2
Pathak, D1
Virmani, T1
Kumar, G1
Alhalmi, A1
Cheng, YT1
Sun, GQ1
Salari, M1
Zare Mehrjerdi, F1
Yadegari, M1
Rezvani, ME1
Shahrokhi Raeini, A1
Harada, H1
Mori, M1
Murata, Y1
Kawanabe, S1
Terada, K1
Matsumoto, T1
Ohe, K1
Enjoji, M1
Zhang, MJ2
Song, ML1
Yang, XM1
Lin, HS1
Chen, WC2
Zhong, XD1
He, CY1
Li, T2
Chen, WG1
Sun, HT1
Ao, HQ1
He, SQ1
Yao, C1
Sun, X4
Pei, H1
Wang, M3
Chang, Q1
Liu, X5
Jiang, N4
Ma, X1
Shin, YJ1
Park, HS1
Jeong, JW1
Kim, JY4
Shim, JJ1
Lee, JL1
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Horrobin, DF1
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Pohl, J1
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Tonelli, LH1
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Tulkova, E1
Nalivaeva, N1
Turner, A1
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Leskov, IL1
Becker, C1
Zeau, B1
Rivat, C1
Blugeot, A1
Benoliel, JJ1
Bächli, H1
Steiner, MA2
Habersetzer, U1
Marsicano, G1
Lutz, B1
Stone, EA3
Lin, Y1
Su, H2
Li, B1
Xing, D2
Bilbo, SD1
Yirmiya, R1
Amat, J1
Paul, ED1
Watkins, LR1
Maier, SF1
Sakakibara, H1
Yoshino, S1
Ma, R1
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Edelsbrunner, ME1
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Hutson, PH1
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Lyckland, J1
Drugan, RC1
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van Rensburg, SJ1
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Wilton, A1
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Otczyk, M1
Mulik, K1
Jaworska-Feil, L1
Basta-Kaim, A1
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Nowak, W1
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McLeod, WL1
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Cottrell, GA1
Nyakas, C1
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Katz, RJ6
Trullas, R1
Platt, JE1
Angelucci, L1
Patacchioli, FR1
Scaccianoce, S1
Martucci, E1
Capasso, M1
Roth, KA3
Schmaltz, K1
Hersh, S1
Albinsson, A1
Björk, A1
Svartengren, J1
Klint, T1
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Nemeroff, CB2
Prasad, A1
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McKittrick, CR1
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López, JF1
Chalmers, DT1
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Schulte Wermeling, D1
Szuran, T1
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Marcilhac, A1
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Mekaouche, M1
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Haapalinna, A1
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Pelto-Huikko, M1
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Scheinin, M1
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Morozova, MG1
Gamper, NL1
Dubinina, EE1
Nuller, IuL1
Lebedev, AV1
Arai, I1
Tsuyuki, Y1
Shiomoto, H1
Satoh, M1
Otomo, S1
Rasmussen, K1
Calligaro, DO1
Czachura, JF1
Dreshfield-Ahmad, LJ1
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Kallman, MJ1
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Preziosi, P1
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Clinical Trials (16)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomized, Double-Blinded, Placebo-Controlled Study Evaluating Vortioxetine for Cognitive Deficits in Persons With Post-COVID-19 Condition[NCT05047952]Phase 2200 participants (Actual)Interventional2021-09-16Completed
Cannabidiol for Treatment Resistant Depression[NCT04732169]Phase 40 participants (Actual)Interventional2021-07-01Withdrawn (stopped due to Investigator decided not to do study, due to insufficient funding.)
Perinatal Stress and Gene Influences: Pathways to Infant Vulnerability[NCT00525226]1,431 participants (Actual)Observational2007-09-30Completed
The Effect of Therapeutic Ketamine Infusions on the Symptoms of Post-Traumatic Stress Disorder in Combat Veterans[NCT03088384]30 participants (Actual)Observational2016-11-28Completed
Understanding the Neurocognitive Effects of Fecal Microbiota Transplantation in Major Depressive Disorder Patients With and Without Irritable Bowel Syndrome[NCT05174273]Phase 2/Phase 3180 participants (Anticipated)Interventional2022-04-06Recruiting
"Proof-of-Concept Stress & Anxiety Dampening Effects of Lpc-37"[NCT03494725]120 participants (Actual)Interventional2018-04-10Completed
Randomized Controlled Experimental Trial Designed to Test the Effects of Probiotics on Mood[NCT03539263]39 participants (Actual)Interventional2016-12-20Completed
The Safety and Effectiveness of Probiotic Supplementation on Bipolar Depression: a Proof of Concept Randomized Controlled Trial[NCT02155972]Phase 216 participants (Actual)Interventional2013-05-31Terminated (stopped due to The trial was terminated because of inability to recruit the needed number of participants)
A Randomized Controlled Trial of the Safety and Efficacy of Fecal Microbiota Transplantation in a Population With Bipolar Disorder[NCT03279224]Phase 2/Phase 335 participants (Actual)Interventional2018-01-01Active, not recruiting
Examining the Effects of a Team-based Running Program on the Mental Health and Cognition of Emerging Adults: A Pilot Study[NCT03143582]30 participants (Actual)Interventional2017-01-31Completed
Probiotics and the Microbiome: Clinical Intervention Trial for Anxiety and Depression[NCT02035878]Phase 275 participants (Actual)Interventional2012-08-31Active, not recruiting
Role of the Gut Microbiome as Determinant of Depression in Multiple Sclerosis Subjects[NCT05808101]120 participants (Anticipated)Observational2022-01-27Recruiting
The Effect of Probiotic Supplementation in Drug-resistant Epilepsy Patients[NCT03403907]45 participants (Actual)Interventional2014-10-01Completed
Role of the Gut Microbiome in Complex Regional Pain Syndrome[NCT03612193]140 participants (Anticipated)Observational2018-12-19Recruiting
Acute and Chronic Impacts of Muscadine Wine Polyphenols on Cognition, Memory, Mood, and Anxiety in Adults Over 50 Years of Age[NCT05541887]25 participants (Anticipated)Interventional2023-08-30Recruiting
A Clinical Trial to Evaluate the Safety and Tolerability of Fecal Microbiota Transplantation in a Population With Obsessive-compulsive Disorder[NCT05720793]Phase 220 participants (Anticipated)Interventional2023-06-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change of Diastolic Blood Pressure (BP) in Response to the TSST

Efficacy of the intake of Lpc-37 on reduction of the increase of the diastolic BP in response to the TSST compared to placebo. (NCT03494725)
Timeframe: 3 minutes before the TSST and 1 minute after the TSST after 5 weeks of study product intake

,
InterventionmmHg (Mean)
Pre-TSST -3minPost-TSST +1min
Lpc-3779.1390.38
Placebo78.4188.36

Change of Mood Scale Scores Over the Course of the Treatment

"Efficacy of the intake of Lpc-37 on the increase of mood scale scores over the course of the treatment~Measured with a daily online diary. Mood was rated by participants on an 11-point scale (0-10; very bad to very well) and monitored through the washout phase (week 1 and 2) and the subsequent treatment phase (weeks 3-7). Higher scores indicate a better mood. Efficacy is defined as an increase, or (in case of a general decrease) reduced decrease for the active treatment group as compared to the placebo group and operationalized as the interaction between time and treatment group. Time is coded as a continuous variable with one average value for each week and participant. Values reflect summary measures for mood ratings on a scale from 0 to 10 for the averaged ratings per participant and week." (NCT03494725)
Timeframe: Daily for 2 weeks before treatment intake and 5 weeks during treatment intake

,
Interventionscore (Mean)
Week 1 (run-in)Week 2 (run-in)Week 3 (treatment)Week 4 (treatment)Week 5 (treatment)Week 6 (treatment)Week 7 (treatment)
Lpc-377.317.537.667.777.737.907.77
Placebo7.277.497.467.537.507.407.55

Change of Perceived Health Status Scores Over the Course of the Treatment

"Efficacy of the intake of Lpc-37 on the increase of perceived health status scores over the course of the treatment.~Measured with a daily online diary. Health status was rated by participants on an 11-point scale (0-10; not at all to very) and monitored through the wash-out phase (week 1 and 2) and the subsequent treatment phase (weeks 3-7). Higher scores indicate a high perceived health.Efficacy is defined as an increase, or (in case of a general decrease) reduced decrease for the active treatment group as compared to the placebo group and operationalized as the interaction between time and treatment group. Time is coded as a continuous variable with one value for each day and participant. Values reflect summary measures for perceived health status on a scale from 0 to 10 for the averaged ratings per participant and week." (NCT03494725)
Timeframe: Daily for 2 weeks before treatment intake and 5 weeks during treatment intake

,
Interventionscore (Mean)
Week 1 (run-in)Week 2 (run-in)Week 3 (treatment)Week 4 (treatment)Week 5 (treatment)Week 6 (treatment)Week 7 (treatment)
Lpc-377.807.897.887.918.058.117.91
Placebo7.867.927.928.017.927.737.75

Change of Perceived Productivity Scores Over the Course of the Treatment

"Efficacy of the intake of Lpc-37 on the increase of perceived productivity scores over the course of the treatment~Measured with a daily online diary. Productivity was rated by participants on an 11-point scale (0-10; not at all to very) and monitored through the wash-out phase (week 1 and 2) and the subsequent treatment phase (weeks 3-7). Higher scores indicate a higher perceived productivity. Efficacy is defined as an increase, or (in case of a general decrease) reduced decrease for the active treatment group as compared to the placebo group and operationalized as the interaction between time and treatment group.Time is coded as a continuous variable with one value for each day and participant. The values reflect summary measures for perceived productivity on a scale from 0 to 10 for the averaged ratings per participant and week." (NCT03494725)
Timeframe: Daily for 2 weeks before treatment intake and 5 weeks during treatment intake

,
Interventionscore (Mean)
Week 1 (run-in)Week 2 (run-in)Week 3 (treatment)Week 4 (treatment)Week 5 (treatment)Week 6 (treatment)Week 7 (treatment)
Lpc-376.987.347.537.487.597.577.50
Placebo7.157.297.307.347.437.317.32

Change of Reported Number of Sleep Disruptions Over the Course of the Treatment

"Efficacy of the intake of Lpc-37 on the decrease of reported number of sleep disruptions over the course of the treatment measured with a daily online diary (mean of week summary).~Sleep disruptions were monitored through the wash-out phase (Week 1 and 2) and the subsequent treatment phase (Weeks 3-7). In the count version, the value can be 0 or a natural number for each day and each participant. Efficacy is defined as a decrease, or (in case of a general increase) reduced increase for the active treatment group as compared to the placebo group and operationalized as the interaction between time and treatment group. Time is coded as a continuous variable with one value for each day and participant. Values reflect summary measures for sleep disruptions (count) for the summed counts per participant and week." (NCT03494725)
Timeframe: Daily for 2 weeks before treatment intake and 5 weeks during treatment intake

,
Interventionsleep disruptions per participant & week (Mean)
Week 1 (run-in)Week 2 (run-in)Week 3 (treatment)Week 4 (treatment)Week 5 (treatment)Week 6 (treatment)Week 7 (treatment)
Lpc-377.305.504.895.433.523.804.66
Placebo6.095.495.114.303.534.025.83

Change of Reported Sleep Disruptions Over the Course of the Treatment by Week (Proportion Yes/Total)

"Efficacy of the intake of Lpc-37 on the decrease of sleep disruptions over the course of the treatment measured with a daily online diary (Proportion (yes/total)).~Sleep disruptions were monitored through the wash-out phase and the subsequent treatment phase for each week. In the binary version, the value is either Yes or No for each day and each participant.~Efficacy is defined as a decrease, or (in case of a general increase) reduced increase for the active treatment group as compared to the placebo group and operationalized as the interaction between time and treatment group. Time is coded as a continuous variable with one value for each day and participant.~The proportion of participants with at least one sleep disruption by treatment group is given, treatment commenced after week 2. Data listed here reflect the proportion of participants who answered Yes (e.g. 0,477 * 44 = 20.99 participants answered with Yes in week 1 in the Lpc-37 group)." (NCT03494725)
Timeframe: Daily for 2 weeks before treatment intake and 5 weeks during treatment intake

,
InterventionProportion of participants (yes/total) (Number)
Week 1 (run-in)Week 2 (run-in)Week 3 (treatment)Week 4 (treatment)Week 5 (treatment)Week 6 (treatment)Week 7 (treatment)
Lpc-370.4770.4350.3540.3670.3060.2790.290
Placebo0.4650.4260.4180.3100.2920.3310.389

Change of sAA in Response to the TSST

Efficacy of the intake of Lpc-37 on reduction of the increase of salivary Alpha-Amylase (sAA) in response to the TSST compared to placebo. (NCT03494725)
Timeframe: 1 minute before the TSST and 1, 10, 20, 30 and 45 minutes after the TSST after 5 weeks of study product intake

,
InterventionU/ml (Mean)
Pre-TSST -2minPost-TSST +1minPost-TSST +10minPost-TSST +20minPost-TSST +30minPost-TSST +45min
Lpc-37154.04246.29146.53130.11125.19141.13
Placebo161.67270.55158.85141.49138.48148.15

Change of Salivary Cortisol in Response to the TSST

Efficacy of the intake of Lpc-37 on reduction of the increase of salivary cortisol in response to the TSST compared to placebo. (NCT03494725)
Timeframe: 1 minute before the TSST and 1, 10, 20, 30 and 45 minutes after the TSST after 5 weeks of study product intake

,
Interventionnmol/L (Mean)
Pre-TSST -2minPost-TSST +1minPost-TSST +10minPost-TSST +20minPost-TSST +30minPost-TSST +45min
Lpc-374.796.969.489.898.046.21
Placebo4.826.858.979.217.716.16

Change of Sleep Duration Over the Course of the Treatment

"Efficacy of the intake of Lpc-37 on the increase of sleep duration over the course of the treatment.~Sleep duration was monitored through the wash-out phase (week 1 and 2) and the subsequent treatment phase (weeks 3-7). Efficacy is defined as an increase, or (in case of a general decrease) reduced decrease for the active treatment group as compared to the placebo group and operationalized as the interaction between time and treatment group. Time is coded as a continuous variable with one value for each day and participant. Summary measures for Sleep duration for the averaged ratings per participant and week" (NCT03494725)
Timeframe: Daily for 2 weeks before treatment intake and 5 weeks during treatment intake

,
Interventionmin (Mean)
Week 1 (run-in)Week 2 (run-in)Week 3 (treatment)Week 4 (treatment)Week 5 (treatment)Week 6 (treatment)Week 7 (treatment)
Lpc-37447.27444.01449.45450.62454.50450.88445.60
Placebo447.45448.13456.90459.81457.26450.16459.66

Change of Sleep Related Recovery Scores Over the Course of the Treatment

"Efficacy of the intake of Lpc-37 on the increase of sleep related recovery scores over the course of the treatment.~Measured with a daily online diary. Sleep related recovery was rated by participants on an 11-point scale (0-10; not at all to very) and monitored throughout the wash-out phase (Week 1 and 2) and the subsequent treatment phase (weeks 3-7). High scores indicate a high recovery.~Efficacy is defined as an increase, or (in case of a general decrease) reduced decrease for the active treatment group as compared to the placebo group and operationalized as the interaction between time and treatment group. Time is coded as a continuous variable with one value for each day and participant. Summary measures for sleep related recovery for the averaged ratings per participant and week." (NCT03494725)
Timeframe: Daily for 2 weeks before treatment intake and 5 weeks during treatment intake

,
Interventionscore (Mean)
Week 1 (run-in)Week 2 (run-in)Week 3 (treatment)Week 4 (treatment)Week 5 (treatment)Week 6 (treatment)Week 7 (treatment)
Lpc-376.717.077.327.307.367.427.31
Placebo6.917.157.277.297.367.107.28

Change of STAI-State Scores in Response to the TSST

"Efficacy of the intake of Lpc-37 on reduction of the increase of STAI-State scores in response to the TSST compared to placebo.~Measured with the german version of the State-Trait-Anxiety Inventory, scale anxiety as a temporary emotional state (STAI-X1). Answers are given on a four-point rating scale ranging from 1=not at all to 4=very true. The score range is 20-80; Higher scores indicate more anxiety." (NCT03494725)
Timeframe: 10 minutes before the TSST and 1 minute after the TSST after 5 weeks of study product intake

,
Interventionscore (Mean)
Pre-TSST -10minPost-TSST +1min
Lpc-3736.0942.38
Placebo36.8343.60

Change of Systolic BP in Response to the TSST

Efficacy of the intake of Lpc-37 on reduction of the increase of the systolic BP in response to the TSST compared to placebo. (NCT03494725)
Timeframe: 3 minutes before the TSST and 1 minute after the TSST after 5 weeks of study product intake

,
InterventionmmHg (Mean)
Pre-TSST -3minPost-TSST +1min
Lpc-37115.11127.47
Placebo114.33129.19

Change of the Heart Rate (HR) in Response to the Trier Social Stress Test (TSST)

Efficacy was defined as a lower increase in HR in response to the TSST following intervention with Lpc-37, compared to placebo. (NCT03494725)
Timeframe: Continuous measurement starting 20 minutes before and ending 20 minutes after the TSST after 5 weeks of product intake. Mean values were calculated per group at seven-time windows before, during and after the TSST

,
Interventionbpm (Mean)
Pre-TSST -20minPre-TSST -10minPre-TSST -3minduring TSST (Interview)during TSST (Arithmetic)Post-TSST +10minPost-TSST +20min
Lpc-3774.8488.1597.34107.56102.7793.3275.88
Placebo74.3486.6997.62105.66100.8190.8174.97

Change of VAS Anxiety Scores in Response to the TSST

"Efficacy of the intake of Lpc-37 on reduction of the increase of VAS anxiety scores in response to the TSST compared to placebo.~Measured with a german version of the Visual Analog Scale (VAS) as a 10cm bipolar scale ranging from not at all to highly. The participant indicated his/her actual perception by placing a mark on a line. VAS scores were obtained by using a ruler and measuring the position of the participants's mark with millimeter precision. To control for possible variations due to printing, the total length of the line was also measured and percentage scores for each participant were computed. Percentage scores range from 0-100. Higher scores indicating greater anxiety." (NCT03494725)
Timeframe: 10 minutes before the TSST, during the TSST and 1 minute after the TSST after 5 weeks of study product intake

,
Interventionscore (Mean)
Pre-TSST -10minInterview TSST (during)Post-TSST +1min
Lpc-376.8020.8510.68
Placebo8.5022.4711.74

Change of VAS Exhaustion Scores in Response to the TSST

"Efficacy of the intake of Lpc-37 on reduction of the increase of VAS exhaustion scores in response to the TSST compared to placebo.~Measured with a german version of the Visual Analog Scale (VAS) as a 10cm bipolar scale ranging from not at all to highly. The participant indicated his/her actual perception by placing a mark on a line. VAS scores were obtained by using a ruler and measuring the position of the participants's mark with millimeter precision. To control for possible variations due to printing, the total length of the line was also measured and percentage scores for each participant were computed. Percentage scores range from 0-100. Higher scores indicating greater exhaustion." (NCT03494725)
Timeframe: 10 minutes before the TSST, during the TSST and 1 minute after the TSST after 5 weeks of study product intake

,
Interventionscore (Mean)
Pre-TSST -10minInterview TSST (during)Post-TSST +1min
Lpc-3721.1819.2022.12
Placebo19.7921.3025.68

Change of VAS Insecurity Scores in Response to the TSST

"Efficacy of the intake of Lpc-37 on reduction of the increase of VAS insecurity scores in response to the TSST compared to placebo.~Measured with a german version of the Visual Analog Scale (VAS) as a 10cm bipolar scale ranging from not at all to highly. The participant indicated his/her actual perception by placing a mark on a line. VAS scores were obtained by using a ruler and measuring the position of the participants's mark with millimeter precision. To control for possible variations due to printing, the total length of the line was also measured and percentage scores for each participant were computed. Percentage scores range from 0-100. Higher scores indicating greater insecurity." (NCT03494725)
Timeframe: 10 minutes before the TSST, during the TSST and 1 minute after the TSST after 5 weeks of study product intake

,
Interventionscore (Mean)
Pre-TSST -10minInterview TSST (during)Post-TSST +1min
Lpc-3714.4745.0823.92
Placebo17.1952.1923.69

Change of VAS Stress Perception Scores in Response to the TSST

"Efficacy of the intake of Lpc-37 on reduction of the increase of VAS Stress perception scores in response to the TSST compared to placebo.~Measured with a german version of the Visual Analog Scale (VAS) as a 10cm bipolar scale ranging from not at all to highly. The participant indicated his/her actual perception by placing a mark on a line. VAS scores were obtained by using a ruler and measuring the position of the participants's mark with millimeter precision. To control for possible variations due to printing, the total length of the line was also measured and percentage scores for each participant were computed. Percentage scores range from 0-100. Higher scores indicating higher perceived stress." (NCT03494725)
Timeframe: 10 minutes before the TSST, during the TSST and 1 minute after the TSST after 5 weeks of study product intake

,
Interventionscore (Mean)
Pre-TSST -10minInterview TSST (during)Post-TSST +1min
Lpc-3719.8947.7131.72
Placebo18.5251.5132.85

Changes in Pre and Post Treatment BAI Scores

"Efficacy of the intake of Lpc-37 on the reduction of Beck Anxiety Inventory (BAI) scores compared to placebo.~Measured with the german version of the Beck Anxiety Inventory as a self-rating scale designed to measure anxiety. It comprises 21 sentences describing feelings that can occur when being anxious. These sentences are rated on a four-point rating scale ranging from 0=not at all to 3=severely, considering the last 7 days. The score range is 0-63; Higher scores indicate higher anxiety." (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.

,
Interventionscore (Mean)
BaselineEnd of Study
Lpc-375.514.75
Placebo5.856.33

Changes in Pre and Post Treatment DASS Anxiety Scores

"Efficacy of the intake of Lpc-37 on the reduction of Depression Anxiety Stress Scale (DASS) anxiety scores compared to placebo.~Measured with the german version of the DASS as a 42-item self report instrument designed to measure negative emotional states of depression, anxiety and stress during the past week. The DASS includes three scales (depression, anxiety and stress) of which each scale includes 14 items that are divided into subscales of 2-5 items of similar content.~Items are answered on a four point rating scale ranging from 0 = not at all to 3 = very much. Scores of each scale are calculated by summing the scores for the relevant items.~The anxiety scale assesses autonomic arousal, skeletal muscle effects, situational anxiety, and subjective experience of anxious affect. The items are 2, 4, 7, 9, 15, 19, 20, 23, 25, 28, 30, 36, 40, 41 and individual scores can range from 0 to 42 with higher scores indicating greater severity of the symptoms." (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.

,
Interventionscore (Mean)
BaselineEnd of Study
Lpc-372.602.44
Placebo3.073.45

Changes in Pre and Post Treatment DASS Depression Scores

"Efficacy of the intake of Lpc-37 on the reduction of Depression Anxiety Stress Scale (DASS) depression scores compared to placebo.~Measured with the german version of the DASS as a 42-item self report instrument designed to measure negative emotional states of depression, anxiety and stress during the past week. The DASS includes three scales (depression, anxiety and stress) of which each scale includes 14 items that are divided into subscales of 2-5 items of similar content.~Items are answered on a four point rating scale ranging from 0 = not at all to 3 = very much. Scores of each scale are calculated by summing the scores for the relevant items.~The Depression scale assesses dysphoria, hopelessness, devaluation of life, self-deprecation, lack of interest/involvement, anhedonia, and inertia. The items are 3, 5, 10, 13, 16, 17, 21, 24, 26, 31, 34, 37, 38, 42 and individual scores can range from 0 to 42 with higher scores indicating greater severity of the symptoms." (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.

,
Interventionscore (Mean)
BaselineEnd of Study
Lpc-374.604.15
Placebo5.215.10

Changes in Pre and Post Treatment DASS Stress Scores

"Efficacy of the intake of Lpc-37 on the reduction of Depression Anxiety Stress Scale (DASS) stress scores compared to placebo.~Measured with the german version of the DASS as a 42-item self report instrument designed to measure negative emotional states of depression, anxiety and stress during the past week. The DASS includes three scales (depression, anxiety and stress) of which each scale includes 14 items that are divided into subscales of 2-5 items of similar content.~Items are answered on a four point rating scale ranging from 0 = not at all to 3 = very much. Scores of each scale are calculated by summing the scores for the relevant items.~The stress scale (items) is sensitive to levels of chronic non-specific arousal.The stress scale items are 1, 6, 8, 11, 12, 14, 18, 22, 27, 29, 32, 33, 35, 39 and individual scores can range from 0 to 42 with higher scores indicating greater severity of the symptoms." (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.

,
Interventionscore (Mean)
BaselineEnd of Study
Lpc-379.768.91
Placebo9.4110.09

Changes in Pre and Post Treatment Diastolic BP

Efficacy of the intake of Lpc-37 on the reduction of diastolic BP. (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.

,
InterventionmmHg (Mean)
BaselineEnd of Study
Lpc-3771.8973.18
Placebo71.6874.62

Changes in Pre and Post Treatment Perceived Stress Scale (PSS) Scores

"Efficacy of the intake of Lpc-37 on the reduction of Perceived Stress Scale (PSS) scores compared to placebo.~Measured with the german version of the PSS as a psychological instrument for measuring stress perception. It assesses how unpredictable, uncontrollable and overloaded participants perceived their lives to have been within the last month. The PSS comprises 14 items that are answered on a five-point rating scale ranging from 0 = never to 4 = very often. Individual scores on the PSS can range from 0 to 56 with higher scores indicating higher perceived stress." (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.

,
Interventionscore (Mean)
BaselineEnd of Study
Lpc-3721.8920.49
Placebo20.7221.56

Changes in Pre and Post Treatment STAI-state Scores

"Efficacy of the intake of Lpc-37 on the reduction of State-Trait-Anxiety-Inventory (STAI)-state scores compared to placebo.~Measured with the german version of the State-Trait-Anxiety Inventory, scale anxiety as a temporary emotional state (STAI-X1). Answers are given on a four-point rating scale ranging from 1=not at all to 4=very true. The score range is 20-80; Higher scores indicate more anxiety." (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.

,
Interventionscore (Mean)
BaselineEnd of Study
Lpc-3733.6535.18
Placebo34.3335.33

Changes in Pre and Post Treatment Systolic BP

Efficacy of the intake of Lpc-37 on the reduction of systolic blood pressure (BP). (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.

,
InterventionmmHg (Mean)
BaselineEnd of Study
Lpc-37119.60121.87
Placebo119.66122.86

Changes in Pre and Post Treatment VAS Anxiety Scores

"Efficacy of the intake of Lpc-37 on the reduction of VAS anxiety scores compared to placebo.~Measured with a german version of the Visual Analog Scale (VAS) as a 10cm bipolar scale ranging from not at all to highly. The participant indicated his/her actual perception by placing a mark on a line. VAS scores were obtained by using a ruler and measuring the position of the participants's mark with millimeter precision. To control for possible variations due to printing, the total length of the line was also measured and percentage scores for each participant were computed. Percentage scores range from 0-100. Higher scores indicating greater anxiety." (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.

,
Interventionscore (Mean)
BaselineEnd of Study
Lpc-377.299.26
Placebo7.587.85

Changes in Pre and Post Treatment VAS Exhaustion Scores

"Efficacy of the intake of Lpc-37 on the reduction of VAS exhaustion scores compared to placebo.~Measured with a german version of the Visual Analog Scale (VAS) as a 10cm bipolar scale ranging from not at all to highly. The participant indicated his/her actual perception by placing a mark on a line. VAS scores were obtained by using a ruler and measuring the position of the participants's mark with millimeter precision. To control for possible variations due to printing, the total length of the line was also measured and percentage scores for each participant were computed. Percentage scores range from 0-100. Higher scores indicating greater exhaustion." (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.

,
Interventionscore (Mean)
BaselineEnd of Study
Lpc-3729.5624.66
Placebo23.1918.45

Changes in Pre and Post Treatment VAS Insecurity Scores

"Efficacy of the intake of Lpc-37 on the reduction of VAS insecurity scores compared to placebo.~Measured with a german version of the Visual Analog Scale (VAS) as a 10cm bipolar scale ranging from not at all to highly. The participant indicated his/her actual perception by placing a mark on a line. VAS scores were obtained by using a ruler and measuring the position of the participants's mark with millimeter precision. To control for possible variations due to printing, the total length of the line was also measured and percentage scores for each participant were computed. Percentage scores range from 0-100. Higher scores indicating greater insecurity." (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.

,
Interventionscore (Mean)
BaselineEnd of Study
Lpc-3713.5816.44
Placebo15.9117.30

Changes in Pre and Post Treatment VAS Stress Perception Scores

"Efficacy of the intake of Lpc-37 on the reduction of Visual Analog Scale (VAS) stress perception scores compared to placebo.~Measured with a german version of the Visual Analog Scale (VAS) as a 10cm bipolar scale ranging from not at all to highly. The participant indicated his/her actual perception by placing a mark on a line. VAS scores were obtained by using a ruler and measuring the position of the participants's mark with millimeter precision. To control for possible variations due to printing, the total length of the line was also measured and percentage scores for each participant were computed. Percentage scores range from 0-100. Higher scores indicating higher perceived stress." (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.

,
Interventionscore (Mean)
BaselineEnd of Study
Lpc-3719.1123.32
Placebo19.3420.67

The Change of the Difference From Baseline and 5 Weeks of Treatment to the Respective Mean of CAR 8pm Measures

"Efficacy of the intake of Lpc-37 on the reduction of the difference of cortisol at 8 pm values to the respective mean before and after 5 weeks of treatment~Efficacy for the CAR variable cortisol at 8 pm is defined in terms of a normalization: Number of participants with normal values (between first and third quantile of reference measures) and numbers of participants with low or high values are compared before treatment and after treatment. More participants in the normal range after treatment is defined as efficacy." (NCT03494725)
Timeframe: Baseline (average of 2 days before first product intake) and end of study (average of 2 days before last product intake

,
Interventionnumber of participants (Number)
Baseline (<25% quantile)Baseline (25% - 75% quantile)Baseline (>75% quantile)End of Study (<25% quantile)End of Study (25% - 75% quantile)End of Study (>75% quantile)
Lpc-374202932822
Placebo6232671830

The Change of the Difference From Baseline and 5 Weeks of Treatment to the Respective Mean of CAR AUCg Measures

"Efficacy of the intake of Lpc-37 on the reduction of the difference of Cortisol Awakening Response (CAR) area under the curve with respect to the ground (AUCg) values to the respective mean before and after 5 weeks of treatment.~The CAR is summarized in the variables AUCg, AUCi, mean increase and peak value. These cortisol indices are frequently used to describe hypothalamic-pituitary-adrenal axis activity and represent information either of the total cortisol production or of the change in cortisol levels. AUCg is the total area under the curve of all measurements (i.e., the intensity or magnitude of the response).~Efficacy for the CAR variables AUCg is defined in terms of a normalization: Number of participants with normal values (between first and third quantile of reference measures) and numbers of participants with low or high values are compared before treatment and after treatment. More participants in the normal range after treatment is defined as efficacy." (NCT03494725)
Timeframe: Baseline (average of 2 days before first product intake) and end of study (average of 2 days before last product intake)

,
Interventionnumber of participants (Number)
Baseline (<25% quantile)Baseline (25% - 75% quantile)Baseline (>75% quantile)End of Study (<25% quantile)End of Study (25% - 75% quantile)End of Study (>75% quantile)
Lpc-3763611112814
Placebo12301373513

The Change of the Difference From Baseline and 5 Weeks of Treatment to the Respective Mean of Cortisol at Awakening Measures

"Efficacy of the intake of Lpc-37 on the reduction of the difference of Cortisol at Awakening values to the respective mean before and after 5 weeks of treatment~Efficacy for the CAR variable cortisol at awakening is defined in terms of a normalization: Number of participants with normal values (between first and third quantile of reference measures) and numbers of participants with low or high values are compared before treatment and after treatment. More participants in the normal range after treatment is defined as efficacy." (NCT03494725)
Timeframe: Baseline (average of 2 days before first product intake) and end of study (average of 2 days before last product intake)

,
Interventionnumber of participants (Number)
Baseline (<25% quantile)Baseline (25% - 75% quantile)Baseline (>75% quantile)End of Study (<25% quantile)End of Study (25% - 75% quantile)End of Study (>75% quantile)
Lpc-371431819268
Placebo16261312349

The Change of the Difference From Baseline and 5 Weeks of Treatment to the Respective Mean of Cortisol Awakening Response (CAR) AUCi Measures

"Efficacy of the intake of Lpc-37 on the reduction of the difference of CAR area under the curve with respect to the increase (AUCi) values to the respective mean before and after the treatment.~The CAR is summarized in the variables AUCg, AUCi, mean increase and peak value. These cortisol indices are frequently used to describe hypothalamic-pituitary-adrenal axis activity and represent information either of the total cortisol production or of the change in cortisol levels. AUCi is calculated with reference to the baseline measurement and it ignores the distance from zero for all measurements and emphasizes the changes over time. Efficacy for the CAR variables AUCi is defined in terms of a normalization: Number of participants with normal values (between first and third quantile of reference measures) and numbers of participants with low or high values are compared before treatment and after treatment. More participants in the normal range after treatment is defined as efficacy." (NCT03494725)
Timeframe: Baseline (average of 2 days before first product intake) and end of study (average of 2 days before last product intake)

,
Interventionnumber of participants (Number)
Baseline (<25% quantile)Baseline (25% - 75% quantile)Baseline (>75% quantile)End of Study (<25% quantile)End of Study (25% - 75% quantile)End of Study (>75% quantile)
Lpc-371634315344
Placebo2228515364

Reviews

6 reviews available for corticosterone and Depression

ArticleYear
Do corticosterone levels predict female depressive-like behavior in rodents?
    Journal of neuroscience research, 2021, Volume: 99, Issue:1

    Topics: Animals; Behavior, Animal; Biomarkers; Corticosterone; Depression; Disease Models, Animal; Female; M

2021
Stress and Depression: a Crucial Role of the Mineralocorticoid Receptor.
    Journal of neuroendocrinology, 2016, Volume: 28, Issue:8

    Topics: Adaptation, Psychological; Animals; Antidepressive Agents; Brain; Corticosterone; Depression; Fludro

2016
Oxidative and nitrosative stress pathways in the brain of socially isolated adult male rats demonstrating depressive- and anxiety-like symptoms.
    Brain structure & function, 2017, Volume: 222, Issue:1

    Topics: Animals; Antioxidants; Anxiety; Apoptosis; Brain; Corticosterone; Depression; Hippocampus; Hypothala

2017
Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction.
    Annals of the New York Academy of Sciences, 2012, Volume: 1261

    Topics: Animals; Biomarkers; Cardiovascular Diseases; Corticosterone; Cushing Syndrome; Depression; Glucocor

2012
Neurotransmitter studies of neuroendocrine pathology in depression.
    Acta psychiatrica Scandinavica. Supplementum, 1980, Volume: 280

    Topics: Acetylcholine; Adolescent; Animals; Brain; Cinanserin; Circadian Rhythm; Corticosterone; Cushing Syn

1980
[Electrophysiologic tests for testing the effects of antidepressant drugs and corticosterone on reactivity of serotonin receptors in the hippocampus].
    Postepy higieny i medycyny doswiadczalnej, 2000, Volume: 54, Issue:3

    Topics: Animals; Antidepressive Agents; Corticosterone; Depression; Electrophysiology; Hippocampus; Humans;

2000

Trials

1 trial available for corticosterone and Depression

ArticleYear
Effect of corticosterone and hydrocortisone on some indicators of anxiety.
    The Journal of clinical endocrinology and metabolism, 1971, Volume: 33, Issue:3

    Topics: Adrenal Glands; Adult; Analysis of Variance; Anxiety; Clinical Trials as Topic; Computers; Corticost

1971

Other Studies

856 other studies available for corticosterone and Depression

ArticleYear
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment.
    Bioorganic & medicinal chemistry, 2018, 07-23, Volume: 26, Issue:12

    Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Cholin

2018
New 2-Pyrazoline and Hydrazone Derivatives as Potent and Selective Monoamine Oxidase A Inhibitors.
    Journal of medicinal chemistry, 2021, 02-25, Volume: 64, Issue:4

    Topics: Animals; Antidepressive Agents; Depression; Hep G2 Cells; Humans; Hydrazones; Mice; Molecular Dockin

2021
Neuroprotective effects of macamide from maca (
    Food & function, 2021, Oct-04, Volume: 12, Issue:19

    Topics: Alkenes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Behavior, Animal;

2021
Anti-depressive effects of Jiao-Tai-Wan on CORT-induced depression in mice by inhibiting inflammation and microglia activation.
    Journal of ethnopharmacology, 2022, Jan-30, Volume: 283

    Topics: Animals; Animals, Outbred Strains; Antidepressive Agents; Behavior, Animal; Corticosterone; Depressi

2022
Behavioral and Neurochemical Changes in Rats with Recurrent Depression induced by chronic unpredictable stress.
    Neuro endocrinology letters, 2021, Volume: 42, Issue:6

    Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Chro

2021
miR-182 mediated the inhibitory effects of NF-κB on the GPR39/CREB/BDNF pathway in the hippocampus of mice with depressive-like behaviors.
    Behavioural brain research, 2022, 02-10, Volume: 418

    Topics: Animals; Brain-Derived Neurotrophic Factor; Computational Biology; Corticosterone; Cyclic AMP Respon

2022
Effects of Importin α1/KPNA1 deletion and adolescent social isolation stress on psychiatric disorder-associated behaviors in mice.
    PloS one, 2021, Volume: 16, Issue:11

    Topics: alpha Karyopherins; Animals; Anxiety; Behavior, Animal; Chemokine CXCL5; Corticosterone; Depression;

2021
Transcranial Direct Current Stimulation Reduces Anxiety, Depression and Plasmatic Corticosterone in a Rat Model of Atypical Generalized Epilepsy.
    Neuroscience, 2022, 01-01, Volume: 480

    Topics: Animals; Anxiety; Corticosterone; Depression; Epilepsy, Absence; Humans; Rats; Rats, Wistar; Transcr

2022
Lipoic acid prevents mirtazapine-induced weight gain in mice without impairs its antidepressant-like action in a neuroendocrine model of depression.
    Behavioural brain research, 2022, 02-15, Volume: 419

    Topics: Animals; Antidepressive Agents; Antioxidants; Behavior, Animal; Cognitive Dysfunction; Corticosteron

2022
Galanin (1-15) Enhances the Behavioral Effects of Fluoxetine in the Olfactory Bulbectomy Rat, Suggesting a New Augmentation Strategy in Depression.
    The international journal of neuropsychopharmacology, 2022, 04-19, Volume: 25, Issue:4

    Topics: Animals; Antidepressive Agents; Corticosterone; Depression; Fluoxetine; Galanin; Humans; Peptide Fra

2022
Alteration of the α5 GABA receptor and 5HTT lead to cognitive deficits associated with major depressive-like behaviors in a 14-day combined stress rat model.
    The International journal of neuroscience, 2023, Volume: 133, Issue:9

    Topics: Acetylcholinesterase; Animals; Cognition; Corticosterone; Depression; Depressive Disorder, Major; Di

2023
Cinnamaldehyde prevents intergenerational effect of paternal depression in mice via regulating GR/miR-190b/BDNF pathway.
    Acta pharmacologica Sinica, 2022, Volume: 43, Issue:8

    Topics: Acrolein; Animals; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Fathers; Hippocamp

2022
    Bioengineered, 2022, Volume: 13, Issue:1

    Topics: Animals; Brain-Derived Neurotrophic Factor; Connexin 43; Corticosterone; Depression; Disease Models,

2022
The Effect of Early Life Stress on Emotional Behaviors in GPR37KO Mice.
    International journal of molecular sciences, 2021, Dec-30, Volume: 23, Issue:1

    Topics: Animals; Anxiety; Avoidance Learning; Behavior, Animal; Body Weight; Brain; Calcium-Calmodulin-Depen

2021
RNA-seq based transcriptome analysis of ethanol extract of saffron protective effect against corticosterone-induced PC12 cell injury.
    BMC complementary medicine and therapies, 2022, Jan-31, Volume: 22, Issue:1

    Topics: Animals; Cell Survival; Corticosterone; Crocus; Depression; Gene Expression Profiling; Neuroprotecti

2022
Sex-specific contribution of glucocorticoid receptor alpha isoforms to anxiety and depressive-like behavior in mice.
    Journal of neuroscience research, 2022, Volume: 100, Issue:5

    Topics: Animals; Anxiety; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Female; Hippocampus

2022
Maternal separation induced resilience to depression and spatial memory deficit despite intensifying hippocampal inflammatory responses to chronic social defeat stress in young adult male rats.
    Behavioural brain research, 2022, 05-03, Volume: 425

    Topics: Animals; Corticosterone; Depression; Hippocampus; Male; Maternal Deprivation; Memory Disorders; Rats

2022
A New Potential Antidepressant: Dexmedetomidine Alleviates Neuropathic Pain-Induced Depression by Increasing Neurogenesis in the Hippocampus.
    Pharmacology, 2022, Volume: 107, Issue:5-6

    Topics: Animals; Antidepressive Agents; Bromodeoxyuridine; Chronic Pain; Corticosterone; Depression; Dexmede

2022
The antidepressant-like effect of formononetin on chronic corticosterone-treated mice.
    Brain research, 2022, 05-15, Volume: 1783

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone;

2022
Lower antidepressant response to fluoxetine is associated with anxiety-like behavior, hippocampal oxidative imbalance, and increase on peripheral IL-17 and IFN-γ levels.
    Behavioural brain research, 2022, 05-03, Volume: 425

    Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Corticosterone; Depression; Disease Model

2022
Something new and something blue: Responses to novelty in a rodent model of depression and epilepsy comorbidity.
    Physiology & behavior, 2022, 05-15, Volume: 249

    Topics: Animals; Anxiety; Comorbidity; Corticosterone; Depression; Disease Models, Animal; Epilepsy; Humans;

2022
Voluntary physical activity increases maternal care and reduces anxiety- and depression-related behaviours during the postpartum period in mice.
    Brain research, 2022, 06-01, Volume: 1784

    Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Female;

2022
Baicalin Coadministration with Lithium Chloride Enhanced Neurogenesis via GSK3β Pathway in Corticosterone Induced PC-12 Cells.
    Biological & pharmaceutical bulletin, 2022, May-01, Volume: 45, Issue:5

    Topics: Antidepressive Agents; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Flavonoids; Gl

2022
Reelin has antidepressant-like effects after repeated or singular peripheral injections.
    Neuropharmacology, 2022, 06-15, Volume: 211

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal

2022
A single dose of ketamine cannot prevent protracted stress-induced anhedonia and neuroinflammation in rats.
    Stress (Amsterdam, Netherlands), 2022, Volume: 25, Issue:1

    Topics: Anhedonia; Animals; Antidepressive Agents; Carrier Proteins; Corticosterone; Depression; Disease Mod

2022
Pharmacological Study on Total Glycosides of Xiebai Protecting against Depression Model.
    Journal of healthcare engineering, 2022, Volume: 2022

    Topics: Adrenocorticotropic Hormone; Animals; Corticosterone; Depression; Dopamine; Drugs, Chinese Herbal; G

2022
Negative air ion exposure ameliorates depression-like behaviors induced by chronic mild stress in mice.
    Environmental science and pollution research international, 2022, Volume: 29, Issue:41

    Topics: Animals; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Ions; Mice; Stress, P

2022
Development of Anxiolytic and Depression-like Behavior in Mice Infected with Mycobacterium lepraemurium.
    Neuroscience, 2022, 06-15, Volume: 493

    Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Corticosterone; Depression; Mice; Mice, Inbred BALB

2022
Early life adversity accelerates epileptogenesis and enhances depression-like behaviors in rats.
    Experimental neurology, 2022, Volume: 354

    Topics: Adverse Childhood Experiences; Animals; Corticosterone; Depression; Disease Models, Animal; Epilepsy

2022
Cerebrolysin® and Environmental Enrichment, Alone or in Combination, Ameliorate Anxiety- and Depressive-Like Behaviors in a Post-Ischemic Depression Model in Mice.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2022, Volume: 31, Issue:7

    Topics: Amino Acids; Animals; Anxiety; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Diseas

2022
Beneficial effects of prolonged 2-phenylethyl alcohol inhalation on chronic distress-induced anxio-depressive-like phenotype in female mice.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 151

    Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Female; Hypo

2022
    Molecules (Basel, Switzerland), 2022, May-26, Volume: 27, Issue:11

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal

2022
High-frequency ultrasound exposure improves depressive-like behavior in an olfactory bulbectomized rat model of depression.
    Neuroreport, 2022, 07-06, Volume: 33, Issue:10

    Topics: Animals; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Male; Olfactory Bulb;

2022
The adrenal steroid profile in adolescent depression: a valuable bio-readout?
    Translational psychiatry, 2022, 06-18, Volume: 12, Issue:1

    Topics: Adolescent; Adult; Corticosterone; Depression; Depressive Disorder, Major; Desoxycorticosterone; Fem

2022
Antidepressant effect of Jujuboside A on corticosterone-induced depression in mice.
    Biochemical and biophysical research communications, 2022, 09-10, Volume: 620

    Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Corticosterone; Cyclic AMP Respon

2022
Prophylactic administration of rosmarinic acid ameliorates depression-associated cardiac abnormalities in Wistar rats: Evidence of serotonergic, oxidative, and inflammatory pathways.
    Journal of biochemical and molecular toxicology, 2022, Volume: 36, Issue:10

    Topics: Animals; Behavior, Animal; Biomarkers; Catalase; Cinnamates; Copper; Corticosterone; Depression; Dep

2022
Hippocampal miR-124 Participates in the Pathogenesis of Depression via Regulating the Expression of BDNF in a Chronic Social Defeat Stress Model of Depression.
    Current neurovascular research, 2022, Volume: 19, Issue:2

    Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Disea

2022
Icariin Improves Glucocorticoid Resistance in a Murine Model of Asthma with Depression Associated with Enhancement of GR Expression and Function.
    Planta medica, 2023, Volume: 89, Issue:3

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Corticosterone; Cytokines; Depression; Disease Models

2023
Loureirin C and Xanthoceraside Prevent Abnormal Behaviors Associated with Downregulation of Brain Derived Neurotrophic Factor and AKT/mTOR/CREB Signaling in the Prefrontal Cortex Induced by Chronic Corticosterone Exposure in Mice.
    Neurochemical research, 2022, Volume: 47, Issue:9

    Topics: Animals; Brain-Derived Neurotrophic Factor; Corticosterone; Cyclic AMP Response Element-Binding Prot

2022
Hippocampal semaphorin 3B improves depression-like behaviours in mice by upregulating synaptic plasticity and inhibiting neuronal apoptosis.
    Journal of neurochemistry, 2022, Volume: 163, Issue:2

    Topics: Animals; Apoptosis; Behavior, Animal; Corticosterone; Depression; Hippocampus; Mice; Neuronal Plasti

2022
Swimming exercise strain-dependently affects maternal care and depression-related behaviors through gestational corticosterone and brain serotonin in postpartum dams.
    Brain research bulletin, 2022, 10-01, Volume: 188

    Topics: Anhedonia; Animals; Brain; Corticosterone; Depression; Depression, Postpartum; Female; Humans; Mater

2022
Brain matrix metalloproteinase-9 activity is altered in the corticosterone mouse model of depression.
    Progress in neuro-psychopharmacology & biological psychiatry, 2023, 01-10, Volume: 120

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Depressive Disorder, M

2023
Antibiotics-induced depression in mice via the microbiota-gut-brain axis.
    Journal of affective disorders, 2022, 12-01, Volume: 318

    Topics: Adrenocorticotropic Hormone; Animals; Anti-Bacterial Agents; Brain-Derived Neurotrophic Factor; Brai

2022
Mechanistic insights into the protective role of eugenol against stress-induced reproductive dysfunction in female rat model.
    Chemico-biological interactions, 2022, Nov-01, Volume: 367

    Topics: Animals; Antioxidants; Corticosterone; Depression; Disease Models, Animal; Estradiol; Eugenol; Femal

2022
Sex differences in peripheral monoamine transmitter and related hormone levels in chronic stress mice with a depression-like phenotype.
    PeerJ, 2022, Volume: 10

    Topics: Androgens; Animals; Corticosterone; Depression; Estrogens; Female; Male; Mice; Mice, Inbred C57BL; N

2022
Antidepressant effects of cherry leaf decoction on a chronic unpredictable mild stress rat model based on the Glu/GABA-Gln metabolic loop.
    Metabolic brain disease, 2022, Volume: 37, Issue:8

    Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Corticosterone; Depression; Disease Mod

2022
β-Arrestin2-biased Drd2 agonist UNC9995 alleviates astrocyte inflammatory injury via interaction between β-arrestin2 and STAT3 in mouse model of depression.
    Journal of neuroinflammation, 2022, Oct-01, Volume: 19, Issue:1

    Topics: Animals; Astrocytes; beta-Arrestin 1; beta-Arrestin 2; Corticosterone; Depression; Depressive Disord

2022
Paeoniflorin exhibits antidepressant activity in rats with postpartum depression via the TSPO and BDNF‑mTOR pathways.
    Acta neurobiologiae experimentalis, 2022, Volume: 82, Issue:3

    Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Carrier Proteins; Corticosterone;

2022
Mahonia Alkaloids (MA) Ameliorate Depression Induced Gap Junction Dysfunction by miR-205/Cx43 Axis.
    Neurochemical research, 2022, Volume: 47, Issue:12

    Topics: Alkaloids; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Connexin 43; Corticost

2022
Resistance Training Modulates Hippocampal Neuroinflammation and Protects Anxiety-Depression-like Dyad Induced by an Emotional Single Prolonged Stress Model.
    Molecular neurobiology, 2023, Volume: 60, Issue:1

    Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Hippocampus;

2023
18β-Glycyrrhetinic Acid Ameliorates Neuroinflammation Linked Depressive Behavior Instigated by Chronic Unpredictable Mild Stress via Triggering BDNF/TrkB Signaling Pathway in Rats.
    Neurochemical research, 2023, Volume: 48, Issue:2

    Topics: Adrenocorticotropic Hormone; Animals; Body Weight; Brain-Derived Neurotrophic Factor; Corticosterone

2023
Investigating neuropsychological and reward-related deficits in a chronic corticosterone-induced model of depression.
    Psychoneuroendocrinology, 2023, Volume: 147

    Topics: Animals; Corticosterone; Depression; Depressive Disorder, Major; Judgment; Male; Rats; Reward

2023
Resveratrol exerts anxiolytic-like effects through anti-inflammatory and antioxidant activities in rats exposed to chronic social isolation.
    Behavioural brain research, 2023, 02-13, Volume: 438

    Topics: Animals; Anti-Anxiety Agents; Anti-Inflammatory Agents; Antioxidants; Behavior, Animal; Corticostero

2023
Anti-depressive-like and cognitive impairment alleviation effects of Gastrodia elata Blume water extract is related to gut microbiome remodeling in ApoE
    Journal of ethnopharmacology, 2023, Feb-10, Volume: 302, Issue:Pt B

    Topics: Animals; Antidepressive Agents; Cognitive Dysfunction; Corticosterone; Depression; Dopamine; Gastrod

2023
The combination of chronic stress and smoke exacerbated depression-like changes and lung cancer factor expression in A/J mice: Involve inflammation and BDNF dysfunction.
    PloS one, 2022, Volume: 17, Issue:11

    Topics: Animals; Antidepressive Agents; bcl-2-Associated X Protein; Brain-Derived Neurotrophic Factor; Corti

2022
The combination of chronic stress and smoke exacerbated depression-like changes and lung cancer factor expression in A/J mice: Involve inflammation and BDNF dysfunction.
    PloS one, 2022, Volume: 17, Issue:11

    Topics: Animals; Antidepressive Agents; bcl-2-Associated X Protein; Brain-Derived Neurotrophic Factor; Corti

2022
The combination of chronic stress and smoke exacerbated depression-like changes and lung cancer factor expression in A/J mice: Involve inflammation and BDNF dysfunction.
    PloS one, 2022, Volume: 17, Issue:11

    Topics: Animals; Antidepressive Agents; bcl-2-Associated X Protein; Brain-Derived Neurotrophic Factor; Corti

2022
The combination of chronic stress and smoke exacerbated depression-like changes and lung cancer factor expression in A/J mice: Involve inflammation and BDNF dysfunction.
    PloS one, 2022, Volume: 17, Issue:11

    Topics: Animals; Antidepressive Agents; bcl-2-Associated X Protein; Brain-Derived Neurotrophic Factor; Corti

2022
The combination of chronic stress and smoke exacerbated depression-like changes and lung cancer factor expression in A/J mice: Involve inflammation and BDNF dysfunction.
    PloS one, 2022, Volume: 17, Issue:11

    Topics: Animals; Antidepressive Agents; bcl-2-Associated X Protein; Brain-Derived Neurotrophic Factor; Corti

2022
The combination of chronic stress and smoke exacerbated depression-like changes and lung cancer factor expression in A/J mice: Involve inflammation and BDNF dysfunction.
    PloS one, 2022, Volume: 17, Issue:11

    Topics: Animals; Antidepressive Agents; bcl-2-Associated X Protein; Brain-Derived Neurotrophic Factor; Corti

2022
The combination of chronic stress and smoke exacerbated depression-like changes and lung cancer factor expression in A/J mice: Involve inflammation and BDNF dysfunction.
    PloS one, 2022, Volume: 17, Issue:11

    Topics: Animals; Antidepressive Agents; bcl-2-Associated X Protein; Brain-Derived Neurotrophic Factor; Corti

2022
The combination of chronic stress and smoke exacerbated depression-like changes and lung cancer factor expression in A/J mice: Involve inflammation and BDNF dysfunction.
    PloS one, 2022, Volume: 17, Issue:11

    Topics: Animals; Antidepressive Agents; bcl-2-Associated X Protein; Brain-Derived Neurotrophic Factor; Corti

2022
The combination of chronic stress and smoke exacerbated depression-like changes and lung cancer factor expression in A/J mice: Involve inflammation and BDNF dysfunction.
    PloS one, 2022, Volume: 17, Issue:11

    Topics: Animals; Antidepressive Agents; bcl-2-Associated X Protein; Brain-Derived Neurotrophic Factor; Corti

2022
Low-Dose IL-2 Attenuated Depression-like Behaviors and Pathological Changes through Restoring the Balances between IL-6 and TGF-β and between Th17 and Treg in a Chronic Stress-Induced Mouse Model of Depression.
    International journal of molecular sciences, 2022, Nov-10, Volume: 23, Issue:22

    Topics: Animals; Corticosterone; Depression; Disease Models, Animal; Interleukin-12; Interleukin-17; Interle

2022
Low-Dose IL-2 Attenuated Depression-like Behaviors and Pathological Changes through Restoring the Balances between IL-6 and TGF-β and between Th17 and Treg in a Chronic Stress-Induced Mouse Model of Depression.
    International journal of molecular sciences, 2022, Nov-10, Volume: 23, Issue:22

    Topics: Animals; Corticosterone; Depression; Disease Models, Animal; Interleukin-12; Interleukin-17; Interle

2022
Low-Dose IL-2 Attenuated Depression-like Behaviors and Pathological Changes through Restoring the Balances between IL-6 and TGF-β and between Th17 and Treg in a Chronic Stress-Induced Mouse Model of Depression.
    International journal of molecular sciences, 2022, Nov-10, Volume: 23, Issue:22

    Topics: Animals; Corticosterone; Depression; Disease Models, Animal; Interleukin-12; Interleukin-17; Interle

2022
Low-Dose IL-2 Attenuated Depression-like Behaviors and Pathological Changes through Restoring the Balances between IL-6 and TGF-β and between Th17 and Treg in a Chronic Stress-Induced Mouse Model of Depression.
    International journal of molecular sciences, 2022, Nov-10, Volume: 23, Issue:22

    Topics: Animals; Corticosterone; Depression; Disease Models, Animal; Interleukin-12; Interleukin-17; Interle

2022
Low-Dose IL-2 Attenuated Depression-like Behaviors and Pathological Changes through Restoring the Balances between IL-6 and TGF-β and between Th17 and Treg in a Chronic Stress-Induced Mouse Model of Depression.
    International journal of molecular sciences, 2022, Nov-10, Volume: 23, Issue:22

    Topics: Animals; Corticosterone; Depression; Disease Models, Animal; Interleukin-12; Interleukin-17; Interle

2022
Low-Dose IL-2 Attenuated Depression-like Behaviors and Pathological Changes through Restoring the Balances between IL-6 and TGF-β and between Th17 and Treg in a Chronic Stress-Induced Mouse Model of Depression.
    International journal of molecular sciences, 2022, Nov-10, Volume: 23, Issue:22

    Topics: Animals; Corticosterone; Depression; Disease Models, Animal; Interleukin-12; Interleukin-17; Interle

2022
Low-Dose IL-2 Attenuated Depression-like Behaviors and Pathological Changes through Restoring the Balances between IL-6 and TGF-β and between Th17 and Treg in a Chronic Stress-Induced Mouse Model of Depression.
    International journal of molecular sciences, 2022, Nov-10, Volume: 23, Issue:22

    Topics: Animals; Corticosterone; Depression; Disease Models, Animal; Interleukin-12; Interleukin-17; Interle

2022
Low-Dose IL-2 Attenuated Depression-like Behaviors and Pathological Changes through Restoring the Balances between IL-6 and TGF-β and between Th17 and Treg in a Chronic Stress-Induced Mouse Model of Depression.
    International journal of molecular sciences, 2022, Nov-10, Volume: 23, Issue:22

    Topics: Animals; Corticosterone; Depression; Disease Models, Animal; Interleukin-12; Interleukin-17; Interle

2022
Low-Dose IL-2 Attenuated Depression-like Behaviors and Pathological Changes through Restoring the Balances between IL-6 and TGF-β and between Th17 and Treg in a Chronic Stress-Induced Mouse Model of Depression.
    International journal of molecular sciences, 2022, Nov-10, Volume: 23, Issue:22

    Topics: Animals; Corticosterone; Depression; Disease Models, Animal; Interleukin-12; Interleukin-17; Interle

2022
The Effects of Acute and Repeated Administration of Ketamine on Memory, Behavior, and Plasma Corticosterone Levels in Female Mice.
    Neuroscience, 2023, 02-21, Volume: 512

    Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Depressive Disorder, Major; Female;

2023
The Effects of Acute and Repeated Administration of Ketamine on Memory, Behavior, and Plasma Corticosterone Levels in Female Mice.
    Neuroscience, 2023, 02-21, Volume: 512

    Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Depressive Disorder, Major; Female;

2023
The Effects of Acute and Repeated Administration of Ketamine on Memory, Behavior, and Plasma Corticosterone Levels in Female Mice.
    Neuroscience, 2023, 02-21, Volume: 512

    Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Depressive Disorder, Major; Female;

2023
The Effects of Acute and Repeated Administration of Ketamine on Memory, Behavior, and Plasma Corticosterone Levels in Female Mice.
    Neuroscience, 2023, 02-21, Volume: 512

    Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Depressive Disorder, Major; Female;

2023
Antidepressant-Like Effects of Edaravone and Minocycline: Investigation of Oxidative Stress, Neuroinflammation, Neurotrophic, and Apoptotic Pathways.
    Neurotoxicity research, 2022, Volume: 40, Issue:6

    Topics: Acetylcholinesterase; Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression;

2022
Antidepressant-Like Effects of Edaravone and Minocycline: Investigation of Oxidative Stress, Neuroinflammation, Neurotrophic, and Apoptotic Pathways.
    Neurotoxicity research, 2022, Volume: 40, Issue:6

    Topics: Acetylcholinesterase; Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression;

2022
Antidepressant-Like Effects of Edaravone and Minocycline: Investigation of Oxidative Stress, Neuroinflammation, Neurotrophic, and Apoptotic Pathways.
    Neurotoxicity research, 2022, Volume: 40, Issue:6

    Topics: Acetylcholinesterase; Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression;

2022
Antidepressant-Like Effects of Edaravone and Minocycline: Investigation of Oxidative Stress, Neuroinflammation, Neurotrophic, and Apoptotic Pathways.
    Neurotoxicity research, 2022, Volume: 40, Issue:6

    Topics: Acetylcholinesterase; Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression;

2022
MAD2B Blunts Chronic Unpredictable Stress and Corticosterone Stimulation-Induced Depression-Like Behaviors in Mice.
    The international journal of neuropsychopharmacology, 2023, 02-14, Volume: 26, Issue:2

    Topics: Animals; Corticosterone; Depression; Disease Models, Animal; Hippocampus; Mice; MicroRNAs; Rats; Str

2023
Antidepressive-Like Effect of
    BioMed research international, 2022, Volume: 2022

    Topics: Aegle; Anhedonia; Animals; Antidepressive Agents; Corticosterone; Depression; Disease Models, Animal

2022
Baicalin Ameliorates Corticosterone-Induced Depression by Promoting Neurodevelopment of Hippocampal via mTOR/GSK3β Pathway.
    Chinese journal of integrative medicine, 2023, Volume: 29, Issue:5

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal

2023
Antidepressant-like effect of endogenous SO
    Naunyn-Schmiedeberg's archives of pharmacology, 2023, Volume: 396, Issue:6

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal

2023
Dynamic Changes of Behavioral Despair, HPA Axis Activity, and Hippocampal Neurogenesis in Male Rats Induced by Social Defeat Stress.
    Journal of integrative neuroscience, 2023, Feb-20, Volume: 22, Issue:2

    Topics: Animals; Corticosterone; Depression; Hippocampus; Hypothalamo-Hypophyseal System; Male; Neurogenesis

2023
SNS alleviates depression-like behaviors in CUMS mice by regluating dendritic spines via NCOA4-mediated ferritinophagy.
    Journal of ethnopharmacology, 2023, Aug-10, Volume: 312

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Dendritic Spines; Depression; Dise

2023
Areca catechu L. ameliorates chronic unpredictable mild stress-induced depression behavior in rats by the promotion of the BDNF signaling pathway.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 164

    Topics: Animals; Antidepressive Agents; Areca; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticos

2023
    Nutrients, 2023, May-26, Volume: 15, Issue:11

    Topics: Animals; Anti-Inflammatory Agents; Anxiety; Brain-Derived Neurotrophic Factor; Corticosterone; Depre

2023
Network analysis of comorbid depression, suicidality and biomarkers on HPA axis among mood disorder patients to psychiatric emergency services.
    Translational psychiatry, 2023, 06-14, Volume: 13, Issue:1

    Topics: Adrenocorticotropic Hormone; Biomarkers; Corticosterone; Depression; Emergency Services, Psychiatric

2023
Wistar-Kyoto rats and chronically stressed Wistar rats present similar depression- and anxiety-like behaviors but different corticosterone and endocannabinoid system modulation.
    Progress in neuro-psychopharmacology & biological psychiatry, 2023, 12-20, Volume: 127

    Topics: Animals; Anxiety; Corticosterone; Depression; Depressive Disorder, Major; Disease Models, Animal; En

2023
Quercetin mitigates depression-like behavior via the suppression of neuroinflammation and oxidative damage in corticosterone-induced mice.
    Journal of chemical neuroanatomy, 2023, Volume: 132

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone;

2023
Dried Loquat Fruit Extract Containing Chlorogenic Acid Prevents Depressive-like Behaviors Induced by Repeated Corticosteroid Injections in Mice.
    Molecules (Basel, Switzerland), 2023, Jul-24, Volume: 28, Issue:14

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Chlorogenic Acid; Corticosterone; Depression; Dise

2023
Reelin Rescues Behavioral, Electrophysiological, and Molecular Metrics of a Chronic Stress Phenotype in a Similar Manner to Ketamine.
    eNeuro, 2023, Volume: 10, Issue:8

    Topics: Animals; Antidepressive Agents; Benchmarking; Corticosterone; Depression; Hippocampus; Ketamine; Mal

2023
Emotional behaviors as well as the hippocampal reelin expression in C57BL/6N male mice chronically treated with corticosterone.
    Pharmacology, biochemistry, and behavior, 2023, Volume: 230

    Topics: Animals; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Emotions; Glucocortic

2023
Comparison of maternal versus postweaning ingestion of a high fat, high sucrose diet on depression-related behavior, novelty reactivity, and corticosterone levels in young, adult rat offspring.
    Behavioural brain research, 2023, 10-18, Volume: 455

    Topics: Animals; Body Weight; Corticosterone; Depression; Diet, High-Fat; Eating; Female; Humans; Lactation;

2023
Social avoidance and altered hypothalamic-pituitary-adrenal axis in a mouse model of anxious depression: The role of LPA
    Behavioural brain research, 2023, 10-18, Volume: 455

    Topics: Animals; Corticosterone; Depression; Disease Models, Animal; Humans; Hypothalamo-Hypophyseal System;

2023
Environmental stress during adolescence promotes depression-like behavior and endocrine abnormalities in rats.
    Behavioural brain research, 2024, 02-04, Volume: 457

    Topics: Animals; Corticosterone; Depression; Female; Leptin; Male; Neuropeptide Y; Progesterone; Rats; Rats,

2024
A comparative analysis of depressive-like behavior: Exploring sex-related differences and insights.
    PloS one, 2023, Volume: 18, Issue:11

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal

2023
Acute stress imposed during adolescence yields heightened anxiety in Sprague Dawley rats that persists into adulthood: Sex differences and potential involvement of the Medial Amygdala.
    Brain research, 2019, 11-15, Volume: 1723

    Topics: Animals; Anxiety; Anxiety Disorders; Brain; Corticomedial Nuclear Complex; Corticosterone; Corticotr

2019
Effects of cholecalciferol on behavior and production of reactive oxygen species in female mice subjected to corticosterone-induced model of depression.
    Naunyn-Schmiedeberg's archives of pharmacology, 2020, Volume: 393, Issue:1

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Cholecalciferol; Corticosterone; Depression; Disea

2020
Effect of Chronic Corticosterone Treatment on Depression-Like Behavior and Sociability in Female and Male C57BL/6N Mice.
    Cells, 2019, 09-01, Volume: 8, Issue:9

    Topics: Animals; Corticosterone; Depression; Female; Male; Mice; Mice, Inbred C57BL; Sex Factors; Social Beh

2019
Deficiency in Androgen Receptor Aggravates the Depressive-Like Behaviors in Chronic Mild Stress Model of Depression.
    Cells, 2019, 09-02, Volume: 8, Issue:9

    Topics: Androgen Antagonists; Animals; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Female

2019
Dammarane sapogenins alleviates depression-like behaviours induced by chronic social defeat stress in mice through the promotion of the BDNF signalling pathway and neurogenesis in the hippocampus.
    Brain research bulletin, 2019, Volume: 153

    Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Corticosterone; Dammaranes; Depre

2019
Systematic analysis of severity in a widely used cognitive depression model for mice.
    Laboratory animals, 2020, Volume: 54, Issue:1

    Topics: Animal Welfare; Animals; Body Weight; Corticosterone; Depression; Disease Models, Animal; Helplessne

2020
Neonatal Immune Activation May Provoke Long-term Depressive Attributes.
    Current neurovascular research, 2019, Volume: 16, Issue:4

    Topics: Animals; Animals, Newborn; Corticosterone; Depression; Depressive Disorder; Disease Models, Animal;

2019
Thymol reverses depression-like behaviour and upregulates hippocampal BDNF levels in chronic corticosterone-induced depression model in female mice.
    The Journal of pharmacy and pharmacology, 2019, Volume: 71, Issue:12

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone;

2019
Antidepressant activity of crocin-I is associated with amelioration of neuroinflammation and attenuates oxidative damage induced by corticosterone in mice.
    Physiology & behavior, 2019, 12-01, Volume: 212

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Carotenoids; Corticosterone; Depression; Hippocamp

2019
Metabolomic evidence for the therapeutic effect of gentiopicroside in a corticosterone-induced model of depression.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 120

    Topics: Animals; Apoptosis; Arachidonic Acid; Cell Line, Tumor; Corticosterone; Depression; Disease Models,

2019
Gamma-aminobutyric acid-producing lactobacilli positively affect metabolism and depressive-like behaviour in a mouse model of metabolic syndrome.
    Scientific reports, 2019, 11-08, Volume: 9, Issue:1

    Topics: Adipose Tissue; Animals; Behavior, Animal; Body Weight; Cholesterol; Corticosterone; Depression; Dis

2019
Fluoxetine attenuates stress-induced depressive-like behavior through modulation of hippocampal GAP43 and neurogenesis in male rats.
    Journal of chemical neuroanatomy, 2020, Volume: 103

    Topics: Animals; Behavior, Animal; Corticosterone; Depression; Fluoxetine; GAP-43 Protein; Hippocampus; Inte

2020
Link between personality and response to THC exposure.
    Behavioural brain research, 2020, 02-03, Volume: 379

    Topics: Animals; Behavior, Animal; Cannabinoid Receptor Agonists; Conditioning, Psychological; Corticosteron

2020
Atopic dermatitis induces anxiety- and depressive-like behaviors with concomitant neuronal adaptations in brain reward circuits in mice.
    Progress in neuro-psychopharmacology & biological psychiatry, 2020, 03-02, Volume: 98

    Topics: Adaptation, Psychological; Animals; Anxiety; Behavior, Animal; Brain Chemistry; Brain-Derived Neurot

2020
Royal jelly reduces depression-like behavior through possible effects on adrenal steroidogenesis in a murine model of unpredictable chronic mild stress.
    Bioscience, biotechnology, and biochemistry, 2020, Volume: 84, Issue:3

    Topics: Adrenal Glands; Animals; Body Weight; Chronic Disease; Corticosterone; Depression; Disease Models, A

2020
Selective activation of estrogen receptors α and β: Implications for depressive-like phenotypes in female mice exposed to chronic unpredictable stress.
    Hormones and behavior, 2020, Volume: 119

    Topics: Animals; Chronic Disease; Corticosterone; Depression; Estradiol; Estrogen Receptor alpha; Estrogen R

2020
β-Catenin Role in the Vulnerability/Resilience to Stress-Related Disorders Is Associated to Changes in the Serotonergic System.
    Molecular neurobiology, 2020, Volume: 57, Issue:3

    Topics: Animals; Anxiety; Behavior, Animal; beta Catenin; Corticosterone; Depression; Hippocampus; Male; Mic

2020
Selective effects of dorsal raphé nucleus glucocorticoid receptor deletion on depression-like behavior in female C57BL/6J mice.
    Neuroscience letters, 2020, 01-19, Volume: 717

    Topics: Animals; Behavior, Animal; Corticosterone; Depression; Depressive Disorder; Dorsal Raphe Nucleus; Fe

2020
Effects of Puerarin on the Ovariectomy-Induced Depressive-Like Behavior in ICR Mice and Its Possible Mechanism of Action.
    Molecules (Basel, Switzerland), 2019, Dec-13, Volume: 24, Issue:24

    Topics: Animals; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Disease Models, Animal; Doub

2019
Differential effects of stress exposure via two types of restraint apparatuses on behavior and plasma corticosterone level in inbred male BALB/cAJcl mice.
    Neuropsychopharmacology reports, 2020, Volume: 40, Issue:1

    Topics: Animals; Anxiety; Behavior, Animal; Body Weight; Corticosterone; Depression; Disease Models, Animal;

2020
Proteomic profiling of the neurons in mice with depressive-like behavior induced by corticosterone and the regulation of berberine: pivotal sites of oxidative phosphorylation.
    Molecular brain, 2019, 12-30, Volume: 12, Issue:1

    Topics: Animals; Behavior, Animal; Berberine; Cell Survival; Corticosterone; Depression; Disease Models, Ani

2019
Fructo-oligosaccharides from Morinda officinalis remodeled gut microbiota and alleviated depression features in a stress rat model.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2020, Volume: 67

    Topics: Animals; Antidepressive Agents; Corticosterone; Depression; Feces; Gastrointestinal Microbiome; Inte

2020
Duloxetine reverses the symptoms of overactive bladder co-existing with depression via the central pathways.
    Pharmacology, biochemistry, and behavior, 2020, Volume: 189

    Topics: Acetanilides; Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Disease

2020
A novel stress re-stress model: modification of re-stressor cue induces long-lasting post-traumatic stress disorder-like symptoms in rats.
    The International journal of neuroscience, 2020, Volume: 130, Issue:9

    Topics: Animals; Anxiety; Behavior, Animal; Cognitive Dysfunction; Corticosterone; Cues; Depression; Disease

2020
The Role of Annexin A1 and Formyl Peptide Receptor 2/3 Signaling in Chronic Corticosterone-Induced Depression-Like behaviors and Impairment in Hippocampal-Dependent Memory.
    CNS & neurological disorders drug targets, 2020, Volume: 19, Issue:1

    Topics: Animals; Annexin A1; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Glucocorticoids;

2020
Exploring the ameliorative role of α7 neuronal nicotinic acetylcholine receptor modulation in epilepsy and associated comorbidities in post-PTZ-kindled mice.
    Epilepsy & behavior : E&B, 2020, Volume: 103, Issue:Pt A

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anticonvulsants; Corticosterone; Depression; Dose-

2020
I. inflexus (Thunb.) Kudo extract improves atopic dermatitis and depressive-like behavior in DfE-induced atopic dermatitis-like disease.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2020, Volume: 67

    Topics: Animals; Behavior, Animal; Cell Line; Corticosterone; Cytokines; Depression; Dermatitis, Atopic; Der

2020
Fast-acting antidepressant-like effects of Reelin evaluated in the repeated-corticosterone chronic stress paradigm.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2020, Volume: 45, Issue:10

    Topics: Animals; Antidepressive Agents; Corticosterone; Depression; Doublecortin Protein; Hippocampus; Neuro

2020
Chronic unpredictable restraint stress increases hippocampal pro-inflammatory cytokines and decreases motivated behavior in rats.
    Stress (Amsterdam, Netherlands), 2020, Volume: 23, Issue:4

    Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Cytokines; Depression; Disease Models, Animal; H

2020
Effect of probiotic administration on gut microbiota and depressive behaviors in mice.
    Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2020, Volume: 28, Issue:1

    Topics: Animals; Behavior, Animal; Corticosterone; Depression; Gastrointestinal Microbiome; Locomotion; Male

2020
Contribution of glia cells specifically astrocytes in the pathology of depression: immunohistochemical study in different brain areas.
    Folia morphologica, 2020, Volume: 79, Issue:3

    Topics: Animals; Astrocytes; Brain; Cell Count; Corticosterone; Depression; Glial Fibrillary Acidic Protein;

2020
Morus nigra leaves extract revokes the depressive-like behavior, oxidative stress, and hippocampal damage induced by corticosterone: a pivotal role of the phenolic syringic acid.
    Behavioural pharmacology, 2020, Volume: 31, Issue:4

    Topics: Animals; Antioxidants; Behavior, Animal; Cell Survival; Corticosterone; Depression; Fluoxetine; Gall

2020
Glucocorticoid and brain-derived neurotrophic factor relationship: a brief investigation into the model of depression by chronic administration of corticosterone.
    Behavioural pharmacology, 2020, Volume: 31, Issue:4

    Topics: Adrenal Glands; Animals; Body Weight; Brain-Derived Neurotrophic Factor; Corpus Striatum; Corticoste

2020
Depression-like behaviors are accompanied by disrupted mitochondrial energy metabolism in chronic corticosterone-induced mice.
    The Journal of steroid biochemistry and molecular biology, 2020, Volume: 200

    Topics: Adenosine Triphosphate; Animals; Corticosterone; Depression; Energy Metabolism; Lipid Metabolism; Li

2020
Valproic acid administration exerts protective effects against stress-related anhedonia in rats.
    Journal of chemical neuroanatomy, 2020, Volume: 105

    Topics: Anhedonia; Animals; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Histone De

2020
(S)-norketamine and (2S,6S)-hydroxynorketamine exert potent antidepressant-like effects in a chronic corticosterone-induced mouse model of depression.
    Pharmacology, biochemistry, and behavior, 2020, Volume: 191

    Topics: Anhedonia; Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Disease Mod

2020
Oleuropein Reverses Repeated Corticosterone-Induced Depressive-Like Behavior in mice: Evidence of Modulating Effect on Biogenic Amines.
    Scientific reports, 2020, 02-24, Volume: 10, Issue:1

    Topics: Anhedonia; Animals; Behavior, Animal; Biogenic Amines; Brain; Corticosterone; Depression; Disease Mo

2020
Prefrontal cortex infusion of beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, produces antidepressant-like effects in a rodent model of depression.
    Neuropsychopharmacology reports, 2020, Volume: 40, Issue:2

    Topics: 3-Hydroxybutyric Acid; Animals; Antidepressive Agents; Corticosterone; Depression; Disease Models, A

2020
Sex differences in hypothalamic-pituitary-adrenal axis regulation after chronic unpredictable stress.
    Brain and behavior, 2020, Volume: 10, Issue:4

    Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Female; Hypothalamo-Hypophyseal Syst

2020
Hypothalamus-pituitary-adrenal axis imbalance and inflammation contribute to sex differences in separation- and restraint-induced depression.
    Hormones and behavior, 2020, Volume: 122

    Topics: Animals; Anxiety, Separation; Corticosterone; Depression; Female; Hypothalamo-Hypophyseal System; In

2020
Infliximab prevents dysfunction of the vas deferens by suppressing inflammation and oxidative stress in rats with chronic stress.
    Life sciences, 2020, Jun-01, Volume: 250

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Corticosterone; Depression; Dose-Respon

2020
Antidepressants of different classes cause distinct behavioral and brain pro- and anti-inflammatory changes in mice submitted to an inflammatory model of depression.
    Journal of affective disorders, 2020, 05-01, Volume: 268

    Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents; Brain; Citalopram; Corticosterone; Cytokin

2020
Prenatal maternal stress alters depression-related symptoms in a strain - and sex-dependent manner in rodent offspring.
    Life sciences, 2020, Jun-15, Volume: 251

    Topics: Animals; Brain; Corticosterone; Depression; Female; Male; Mice; Mice, Inbred C57BL; Pregnancy; Pregn

2020
The neuroprotective effect of Riparin IV on oxidative stress and neuroinflammation related to chronic stress-induced cognitive impairment.
    Hormones and behavior, 2020, Volume: 122

    Topics: Animals; Antioxidants; Behavior, Animal; Brain; Chronic Disease; Cognitive Dysfunction; Corticostero

2020
Apocynin as an antidepressant agent: in vivo behavior and oxidative parameters modulation.
    Behavioural brain research, 2020, 06-18, Volume: 388

    Topics: Acetophenones; Animals; Antidepressive Agents; Antioxidants; Brain; Corticosterone; Depression; Male

2020
Sepsis survivor mice exhibit a behavioral endocrine syndrome with ventral hippocampal dysfunction.
    Psychoneuroendocrinology, 2020, Volume: 117

    Topics: Acute Disease; Animals; Anxiety; Behavior, Animal; Corticosterone; Critical Illness; Depression; Dis

2020
The influence of the duration of chronic unpredictable mild stress on the behavioural responses of C57BL/6J mice.
    Behavioural pharmacology, 2020, Volume: 31, Issue:6

    Topics: Animals; Behavior, Animal; Body Weight; Corticosterone; Depression; Disease Models, Animal; Hindlimb

2020
Role of glucocorticoid receptor phosphorylation-mediated synaptic plasticity in anxiogenic and depressive behaviors induced by monosodium glutamate.
    Naunyn-Schmiedeberg's archives of pharmacology, 2021, Volume: 394, Issue:1

    Topics: Animals; Anxiety; Behavior, Animal; Brain; Brain-Derived Neurotrophic Factor; Corticosterone; Dendri

2021
Effects of Chronic Cannabidiol Treatment in the Rat Chronic Unpredictable Mild Stress Model of Depression.
    Biomolecules, 2020, 05-22, Volume: 10, Issue:5

    Topics: Animals; Body Weight; Cannabidiol; Corticosterone; Depression; Exploratory Behavior; Injections, Int

2020
Ginsenoside 20(S)-protopanaxadiol attenuates depressive-like behaviour and neuroinflammation in chronic unpredictable mild stress-induced depressive rats.
    Behavioural brain research, 2020, 09-01, Volume: 393

    Topics: Animals; Apoptosis; Corticosterone; Cytokines; Depression; Disease Models, Animal; Encephalitis; Gin

2020
Guanosine potentiates the antidepressant-like effect of subthreshold doses of ketamine: Possible role of pro-synaptogenic signaling pathway.
    Journal of affective disorders, 2020, 06-15, Volume: 271

    Topics: Animals; Antidepressive Agents; Corticosterone; Depression; Guanosine; Humans; Ketamine; Mice; Prefr

2020
Probiotic treatment (Bifidobacterium longum subsp. longum 35624™) affects stress responsivity in male rats after chronic corticosterone exposure.
    Behavioural brain research, 2020, 09-01, Volume: 393

    Topics: Animals; Behavior, Animal; Bifidobacterium; Brain; Corticosterone; Depression; Doublecortin Domain P

2020
Endurance training exerts time-dependent modulation on depressive responses and circadian rhythms of corticosterone and BDNF in the rats with pinealectomy.
    Brain research bulletin, 2020, Volume: 162

    Topics: Animals; Brain-Derived Neurotrophic Factor; Circadian Rhythm; Corticosterone; Depression; Endurance

2020
Brain stimulation rewarding experience attenuates neonatal clomipramine-induced adulthood anxiety by reversal of pathological changes in the amygdala.
    Progress in neuro-psychopharmacology & biological psychiatry, 2020, 12-20, Volume: 103

    Topics: Amygdala; Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Anxiety; Biogenic Monoamines;

2020
Pitolisant protects mice chronically treated with corticosterone from some behavioral but not metabolic changes in corticosterone-induced depression model.
    Pharmacology, biochemistry, and behavior, 2020, Volume: 196

    Topics: Animals; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Histamine H3 Antagoni

2020
Mechanisms underlying remediation of depression-associated anxiety by chronic N-acetyl cysteine treatment.
    Psychopharmacology, 2020, Volume: 237, Issue:10

    Topics: Acetylcysteine; Amygdala; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Corticostero

2020
Cholecalciferol abolishes depressive-like behavior and hippocampal glucocorticoid receptor impairment induced by chronic corticosterone administration in mice.
    Pharmacology, biochemistry, and behavior, 2020, Volume: 196

    Topics: Animals; Antidepressive Agents, Second-Generation; Beclin-1; Behavior, Animal; Cholecalciferol; Cort

2020
Ketamine contributes to the alteration of Ca
    Neuroscience letters, 2020, 09-14, Volume: 735

    Topics: Analgesics; Animals; Antidepressive Agents; Calcium Signaling; Corticosterone; Depression; Female; K

2020
New insights into the effects of caffeine on adult hippocampal neurogenesis in stressed mice: Inhibition of CORT-induced microglia activation.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020, Volume: 34, Issue:8

    Topics: Animals; Antidepressive Agents; Caffeine; Corticosterone; Depression; Disease Models, Animal; Hippoc

2020
Chronic Corticosterone Elevation Suppresses Adult Hippocampal Neurogenesis by Hyperphosphorylating Huntingtin.
    Cell reports, 2020, 07-07, Volume: 32, Issue:1

    Topics: Aging; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; Cyclin-Dependen

2020
Subthreshold doses of guanosine plus ketamine elicit antidepressant-like effect in a mouse model of depression induced by corticosterone: Role of GR/NF-κB/IDO-1 signaling.
    Neurochemistry international, 2020, Volume: 139

    Topics: Animals; Antidepressive Agents; Corticosterone; Depression; Disease Models, Animal; Drug Therapy, Co

2020
Cyclical administration of corticosterone results in aggravation of depression-like behaviors and accompanying downregulations in reelin in an animal model of chronic stress relevant to human recurrent depression.
    Physiology & behavior, 2020, 10-01, Volume: 224

    Topics: Animals; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Down-Regulation; Extr

2020
Chronic stress followed by social isolation promotes depressive-like behaviour, alters microglial and astrocyte biology and reduces hippocampal neurogenesis in male mice.
    Brain, behavior, and immunity, 2021, Volume: 91

    Topics: Animals; Astrocytes; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Hippocamp

2021
Antidepressant-like effects of Lactobacillus plantarum DP189 in a corticosterone-induced rat model of chronic stress.
    Behavioural brain research, 2020, 10-01, Volume: 395

    Topics: Animals; Antidepressive Agents; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Corticosterone;

2020
Long-term exercise from adolescence to adulthood reduces anxiety- and depression-like behaviors following maternal immune activation in offspring.
    Physiology & behavior, 2020, 11-01, Volume: 226

    Topics: Adjuvants, Immunologic; Animals; Anxiety; Anxiety Disorders; Behavior, Animal; Corticosterone; Depre

2020
Ketamine, but not guanosine, as a prophylactic agent against corticosterone-induced depressive-like behavior: Possible role of long-lasting pro-synaptogenic signaling pathway.
    Experimental neurology, 2020, Volume: 334

    Topics: Animals; Antidepressive Agents; Corticosterone; Depression; Guanosine; Hindlimb Suspension; Hippocam

2020
Phosphodiesterase 2 inhibitor Hcyb1 reverses corticosterone-induced neurotoxicity and depression-like behavior.
    Psychopharmacology, 2020, Volume: 237, Issue:11

    Topics: Animals; Antidepressive Agents; Corticosterone; Cyclic Nucleotide Phosphodiesterases, Type 2; Depres

2020
The Effect of Swimming on Anxiety-Like Behaviors and Corticosterone in Stressed and Unstressed Rats.
    International journal of environmental research and public health, 2020, 09-14, Volume: 17, Issue:18

    Topics: Animals; Anxiety; Corticosterone; Depression; Male; Rats; Rats, Wistar; Stress, Psychological; Swimm

2020
Antistress and antidepressant properties of dapoxetine and vortioxetine.
    Acta neurobiologiae experimentalis, 2020, Volume: 80, Issue:3

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Benzylamines; Corticosterone; Depression; Male; Na

2020
Curcumin Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-Like Behaviors via Restoring Changes in Oxidative Stress and the Activation of Nrf2 Signaling Pathway in Rats.
    Oxidative medicine and cellular longevity, 2020, Volume: 2020

    Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; Curcumin; Depression;

2020
Bag-1 mediates glucocorticoid receptor trafficking to mitochondria after corticosterone stimulation: Potential role in regulating affective resilience.
    Journal of neurochemistry, 2021, Volume: 158, Issue:2

    Topics: Affect; Anhedonia; Animals; Corticosterone; Depression; DNA-Binding Proteins; Dose-Response Relation

2021
Low corticosterone levels attenuate late life depression and enhance glutamatergic neurotransmission in female rats.
    Acta pharmacologica Sinica, 2021, Volume: 42, Issue:6

    Topics: Animals; Astrocytes; Corticosterone; Depression; Excitatory Amino Acid Transporter 2; Female; Glutam

2021
Indirect exposure to socially defeated conspecifics using recorded video activates the HPA axis and reduces reward sensitivity in mice.
    Scientific reports, 2020, 10-09, Volume: 10, Issue:1

    Topics: Anhedonia; Animals; Brain; Choice Behavior; Corticosterone; Depression; Disease Models, Animal; Empa

2020
Sex-specific Effects of Lipopolysaccharide on Hippocampal Mitochondrial Processes in Neuroinflammatory Model of Depression.
    Neuroscience, 2020, 12-15, Volume: 451

    Topics: Animals; Corticosterone; Depression; Female; Hippocampus; Hypothalamo-Hypophyseal System; Lipopolysa

2020
Maternal Separation Model of Postpartum Depression: Potential Role for Nucleus Accumbens Dopamine D1-D2 Receptor Heteromer.
    Neurochemical research, 2020, Volume: 45, Issue:12

    Topics: Animals; Anxiety; Corticosterone; Depression; Depression, Postpartum; Female; Male; Maternal Behavio

2020
Antidepressant-like mechanism of honokiol in a rodent model of corticosterone-induced depression.
    Journal of integrative neuroscience, 2020, Sep-30, Volume: 19, Issue:3

    Topics: Animals; Antidepressive Agents; Biphenyl Compounds; Corticosterone; Depression; Disease Models, Anim

2020
Dicaffeoylquinic acids alleviate memory loss via reduction of oxidative stress in stress-hormone-induced depressive mice.
    Pharmacological research, 2020, Volume: 161

    Topics: Animals; Antidepressive Agents; Antioxidants; Astrocytes; Behavior, Animal; Cells, Cultured; Cortico

2020
Effects of body weight-supported treadmill training at different speeds on the motor function and depressive behaviors after spinal cord injury in rats.
    Neuroreport, 2020, 12-16, Volume: 31, Issue:18

    Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Exercise T

2020
The influence of rat strain on the development of neuropathic pain and comorbid anxio-depressive behaviour after nerve injury.
    Scientific reports, 2020, 12-01, Volume: 10, Issue:1

    Topics: Animals; Anxiety; Behavior, Animal; Comorbidity; Corticosterone; Depression; Feces; Gait; Hyperalges

2020
2-Phenylethylamine (PEA) Ameliorates Corticosterone-Induced Depression-Like Phenotype via the BDNF/TrkB/CREB Signaling Pathway.
    International journal of molecular sciences, 2020, Nov-30, Volume: 21, Issue:23

    Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; Cyclic AMP Response El

2020
Adult neurogenesis augmentation attenuates anhedonia and HPA axis dysregulation in a mouse model of chronic stress and depression.
    Psychoneuroendocrinology, 2021, Volume: 124

    Topics: Anhedonia; Animals; Behavior, Animal; Corticosterone; Depression; Depressive Disorder, Major; Diseas

2021
Uncaria rhynchophylla ameliorates unpredictable chronic mild stress-induced depression in mice via activating 5-HT
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2021, Volume: 81

    Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Computational Biology; Corticosterone;

2021
Naringenin improves depressive- and anxiety-like behaviors in mice exposed to repeated hypoxic stress through modulation of oxido-inflammatory mediators and NF-kB/BDNF expressions.
    Brain research bulletin, 2021, Volume: 169

    Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Brain; Brain-Derived Neurotrophic Fact

2021
Ursolic acid abrogates depressive-like behavior and hippocampal pro-apoptotic imbalance induced by chronic unpredictable stress.
    Metabolic brain disease, 2021, Volume: 36, Issue:3

    Topics: Animals; Antidepressive Agents; Apoptosis; Behavior, Animal; Corticosterone; Depression; Fluoxetine;

2021
Protective Effects of Milk Casein on the Brain Function and Behavior in a Mouse Model of Chronic Stress.
    Journal of agricultural and food chemistry, 2021, Feb-17, Volume: 69, Issue:6

    Topics: Animals; Behavior, Animal; Brain; Caseins; Corticosterone; Depression; Disease Models, Animal; Mice;

2021
Knockout of the circadian gene, Per2, disrupts corticosterone secretion and results in depressive-like behaviors and deficits in startle responses.
    BMC neuroscience, 2021, 01-28, Volume: 22, Issue:1

    Topics: Animals; Circadian Rhythm; Corticosterone; Depression; Hypothalamo-Hypophyseal System; Male; Mice; M

2021
Indoxyl sulfate caused behavioral abnormality and neurodegeneration in mice with unilateral nephrectomy.
    Aging, 2021, 02-17, Volume: 13, Issue:5

    Topics: Affect; Animals; Anxiety; Behavior, Animal; Brain-Derived Neurotrophic Factor; Carbon; Cell Survival

2021
Metformin Attenuates the Metabolic Disturbance and Depression-like Behaviors Induced by Corticosterone and Mediates the Glucose Metabolism Pathway.
    Pharmacopsychiatry, 2021, Volume: 54, Issue:3

    Topics: Animals; Chromatography, Liquid; Corticosterone; Depression; Glucose; Humans; Metformin; Rats; Tande

2021
Early Enriched Environment Prevents Epigenetic p11 Gene Changes Induced by Adulthood Stress in Mice.
    International journal of molecular sciences, 2021, Feb-15, Volume: 22, Issue:4

    Topics: Acetylation; Animals; Annexin A2; Corticosterone; Depression; Epigenesis, Genetic; Gene Expression;

2021
Venlafaxine reduces the striatal il6/il10 ratio and increases hippocampal GR expression in female mice subjected to chronic social instability stress.
    Stress (Amsterdam, Netherlands), 2021, Volume: 24, Issue:5

    Topics: Animals; Corticosterone; Depression; Female; Hippocampus; Interleukin-10; Interleukin-6; Mice; Stres

2021
Sleep disturbance induces depressive behaviors and neuroinflammation by altering the circadian oscillations of clock genes in rats.
    Neuroscience research, 2021, Volume: 171

    Topics: Animals; Corticosterone; Depression; Hypothalamo-Hypophyseal System; Pituitary-Adrenal System; Rats;

2021
Is Riparin III a promising drug in the treatment for depression?
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2021, Jul-01, Volume: 162

    Topics: Animals; Behavior, Animal; Benzamides; Corticosterone; Depression; Disease Models, Animal; Female; M

2021
Altered acoustic startle, prepulse facilitation, and object recognition memory produced by corticosterone withdrawal in male rats.
    Behavioural brain research, 2021, 06-25, Volume: 408

    Topics: Animals; Anti-Inflammatory Agents; Behavior, Animal; Cognitive Dysfunction; Corticosterone; Depressi

2021
Exercise and fluoxetine treatment during adolescence protect against early life stress-induced behavioral abnormalities in adult rats.
    Pharmacology, biochemistry, and behavior, 2021, Volume: 205

    Topics: Animals; Animals, Newborn; Antidepressive Agents, Second-Generation; Anxiety; Behavior, Animal; Cort

2021
A single administration of ascorbic acid rapidly reverses depressive-like behavior and hippocampal synaptic dysfunction induced by corticosterone in mice.
    Chemico-biological interactions, 2021, Jun-01, Volume: 342

    Topics: Animals; Antidepressive Agents; Ascorbic Acid; Corticosterone; Dendritic Spines; Depression; Female;

2021
Neuroprotective and Antioxidant Effects of Riparin I in a Model of Depression Induced by Corticosterone in Female Mice.
    Neuropsychobiology, 2022, Volume: 81, Issue:1

    Topics: Animals; Antioxidants; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; Depressi

2022
Synergy of oxytocin and citalopram in modulating Itgb3/Chl1 interplay: Relevance to sensitivity to SSRI therapy.
    Psychoneuroendocrinology, 2021, Volume: 129

    Topics: Animals; Antidepressive Agents; Anxiety; Cell Adhesion Molecules; Citalopram; Corticosterone; Depres

2021
Ketamine, but not fluoxetine, rapidly rescues corticosterone-induced impairments on glucocorticoid receptor and dendritic branching in the hippocampus of mice.
    Metabolic brain disease, 2021, Volume: 36, Issue:8

    Topics: Animals; Corticosterone; Depression; Fluoxetine; Hippocampus; Ketamine; Mice; Receptors, Glucocortic

2021
5-HT
    ACS chemical neuroscience, 2021, 06-02, Volume: 12, Issue:11

    Topics: Animals; Anxiety; Corticosterone; Depression; Fluoxetine; Hippocampus; Mice; Serotonin

2021
Antidepressant-like effects of acupuncture via modulation of corticosterone, sex hormones, and hippocampal BDNF expression in male rats.
    Brain research bulletin, 2021, Volume: 173

    Topics: Acupuncture Therapy; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; D

2021
Effects of enriched environment on depression and anxiety-like behavior induced by early life stress: A comparison between different periods.
    Behavioural brain research, 2021, 08-06, Volume: 411

    Topics: Age Factors; Animals; Anxiety; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Enviro

2021
A low-dose combination of ketamine and guanosine counteracts corticosterone-induced depressive-like behavior and hippocampal synaptic impairments via mTORC1 signaling.
    Progress in neuro-psychopharmacology & biological psychiatry, 2021, 12-20, Volume: 111

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Corticosterone; Depression; Dose-Re

2021
Quantitation of six steroid hormones by ultra-performance liquid chromatography-tandem mass spectrometry in plasma and prefrontal cortex samples from rats with chronic unpredictable mild stress-induced depression.
    Biomedical chromatography : BMC, 2021, Volume: 35, Issue:11

    Topics: Animals; Chromatography, High Pressure Liquid; Corticosterone; Depression; Disease Models, Animal; L

2021
Dietary EPA-Enriched Phospholipids Alleviate Chronic Stress and LPS-Induced Depression- and Anxiety-Like Behavior by Regulating Immunity and Neuroinflammation.
    Molecular nutrition & food research, 2021, Volume: 65, Issue:17

    Topics: Animals; Anxiety; Behavior, Animal; Brain; Corticosterone; Depression; Disease Models, Animal; Eicos

2021
Komagataella pastoris KM71H modulates neuroimmune and oxidative stress parameters in animal models of depression: A proposal for a new probiotic with antidepressant-like effect.
    Pharmacological research, 2021, Volume: 171

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Blood-Brain Barrier; Brain; Corticosterone; Depres

2021
Legumain knockout improves repeated corticosterone injection-induced depression-like emotional and cognitive deficits.
    Behavioural brain research, 2021, 09-10, Volume: 413

    Topics: Animals; Behavior, Animal; Cognitive Dysfunction; Corticosterone; Cysteine Endopeptidases; Depressio

2021
Low doses of ketamine and guanosine abrogate corticosterone-induced anxiety-related behavior, but not disturbances in the hippocampal NLRP3 inflammasome pathway.
    Psychopharmacology, 2021, Volume: 238, Issue:9

    Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Guanosine; Hippocampus; Inflammasome

2021
Behavioral alterations, brain oxidative stress, and elevated levels of corticosterone associated with a pressure injury model in male mice.
    Journal of basic and clinical physiology and pharmacology, 2022, Nov-01, Volume: 33, Issue:6

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain; Corticosterone; Depression; Disease Models,

2022
Therapeutic Potential of Curcumin in Reversing the Depression and Associated Pseudodementia via Modulating Stress Hormone, Hippocampal Neurotransmitters, and BDNF Levels in Rats.
    Neurochemical research, 2021, Volume: 46, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain-Derived Neurotrophic Factor; Corticosterone;

2021
Synergistic effects of combined therapy with transcranial photobiomodulation and enriched environment on depressive- and anxiety-like behaviors in a mice model of noise stress.
    Lasers in medical science, 2022, Volume: 37, Issue:2

    Topics: Animals; Anxiety; Behavior, Animal; Brain-Derived Neurotrophic Factor; Combined Modality Therapy; Co

2022
Highly palatable food access during adolescence increased anxiety-/depression-like behaviors in male, but not in female, rats.
    Nutritional neuroscience, 2018, Volume: 21, Issue:7

    Topics: Animals; Anxiety; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; D

2018
Mangiferin prevents corticosterone-induced behavioural deficits via alleviation of oxido-nitrosative stress and down-regulation of indoleamine 2,3-dioxygenase (IDO) activity.
    Neurological research, 2017, Volume: 39, Issue:8

    Topics: Animals; Anti-Inflammatory Agents; Anxiety; Behavior, Animal; Corticosterone; Depression; Down-Regul

2017
Ovarian hormones modify anxiety behavior and glucocorticoid receptors after chronic social isolation stress.
    Behavioural brain research, 2017, 06-15, Volume: 328

    Topics: Animals; Anxiety; Chronic Disease; Corticosterone; Depression; Estrous Cycle; Female; Hippocampus; H

2017
Curcumin reverses the depressive-like behavior and insulin resistance induced by chronic mild stress.
    Metabolic brain disease, 2017, Volume: 32, Issue:4

    Topics: Animals; Behavior, Animal; Blood Glucose; Corticosterone; Curcumin; Depression; Disease Models, Anim

2017
Depressive behavior induced by unpredictable chronic mild stress increases dentin hypersensitivity in rats.
    Archives of oral biology, 2017, Volume: 80

    Topics: Animals; Corticosterone; Dentin Sensitivity; Depression; Disease Models, Animal; Glial Fibrillary Ac

2017
Molecular Adaptations to Social Defeat Stress and Induced Depression in Mice.
    Molecular neurobiology, 2018, Volume: 55, Issue:4

    Topics: Animals; Binding Sites; Chronic Disease; Corticosterone; Depression; Gene Expression Profiling; Gene

2018
Hyperoside protects against chronic mild stress-induced learning and memory deficits.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 91

    Topics: Animals; Brain-Derived Neurotrophic Factor; Carbazoles; Chronic Disease; Cognition; Corticosterone;

2017
Intergenerational accumulation of impairments in maternal behavior following postnatal social stress.
    Psychoneuroendocrinology, 2017, Volume: 82

    Topics: Aggression; Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Female; Hypothalamo-Hypo

2017
Elevated paternal glucocorticoid exposure modifies memory retention in female offspring.
    Psychoneuroendocrinology, 2017, Volume: 83

    Topics: Animals; Anxiety; Anxiety Disorders; Cognition; Corticosterone; Depression; Epigenesis, Genetic; Fat

2017
JIEYUANSHEN DECOCTION EXERTS ANTIDEPRESSANT EFFECTS ON DEPRESSIVE RAT MODEL VIA REGULATING HPA AXIS AND THE LEVEL OF AMINO ACIDS NEUROTRANSMITTER.
    African journal of traditional, complementary, and alternative medicines : AJTCAM, 2017, Volume: 14, Issue:2

    Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Chronic Disease; Corticosterone; Cortic

2017
Antidepressive effects of ginsenoside Rg1 via regulation of HPA and HPG axis.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 92

    Topics: Affect; Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Disease Models

2017
Methyl jasmonate attenuated lipopolysaccharide-induced depressive-like behaviour in mice.
    Journal of psychiatric research, 2017, Volume: 94

    Topics: Acetates; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; Brain;

2017
Preventive Effects of Ginseng Total Saponins on Chronic Corticosterone-Induced Impairment in Astrocyte Structural Plasticity and Hippocampal Atrophy.
    Phytotherapy research : PTR, 2017, Volume: 31, Issue:9

    Topics: Animals; Antidepressive Agents; Astrocytes; Atrophy; Corticosterone; Depression; Disease Models, Ani

2017
Exposure to chronic variable social stress during adolescence alters affect-related behaviors and adrenocortical activity in adult male and female inbred mice.
    Developmental psychobiology, 2017, Volume: 59, Issue:6

    Topics: Affect; Animals; Behavior, Animal; Corticosterone; Depression; Exploratory Behavior; Female; Male; M

2017
Ferulic acid reverses depression-like behavior and oxidative stress induced by chronic corticosterone treatment in mice.
    Steroids, 2017, Volume: 125

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Biomarkers; Corticosterone; Coumaric Acids; Depres

2017
Profiling coping strategies in male and female rats: Potential neurobehavioral markers of increased resilience to depressive symptoms.
    Hormones and behavior, 2017, Volume: 95

    Topics: Adaptation, Psychological; Animals; Behavior, Animal; Biomarkers; Brain; Corticosterone; Dehydroepia

2017
Insights into the potential antidepressant mechanisms of cilostazol in chronically restraint rats: impact on the Nrf2 pathway.
    Behavioural pharmacology, 2018, Volume: 29, Issue:1

    Topics: Animals; Antidepressive Agents; Antioxidants; Cilostazol; Corticosterone; Depression; Depressive Dis

2018
Reduced hippocampal IL-10 expression, altered monoaminergic activity and anxiety and depressive-like behavior in female mice subjected to chronic social instability stress.
    Behavioural brain research, 2017, 09-29, Volume: 335

    Topics: Animals; Anxiety; Anxiety Disorders; Behavior, Animal; Biogenic Monoamines; Corticosterone; Cytokine

2017
Fluoxetine coupled with zinc in a chronic mild stress model of depression: Providing a reservoir for optimum zinc signaling and neuronal remodeling.
    Pharmacology, biochemistry, and behavior, 2017, Volume: 160

    Topics: Animals; Antidepressive Agents, Second-Generation; Brain; Chronic Disease; Corticosterone; Depressio

2017
Can Ocimum basilicum relieve chronic unpredictable mild stress-induced depression in mice?
    Experimental and molecular pathology, 2017, Volume: 103, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone;

2017
Metformin and ascorbic acid combination therapy ameliorates type 2 diabetes mellitus and comorbid depression in rats.
    Brain research, 2017, Nov-01, Volume: 1674

    Topics: Animals; Ascorbic Acid; Biogenic Monoamines; Blood Glucose; Comorbidity; Corticosterone; Cytokines;

2017
Distinct modifications of hippocampal glucocorticoid receptor phosphorylation and FKBPs by lipopolysaccharide in depressive female and male rats.
    Journal of psychopharmacology (Oxford, England), 2017, Volume: 31, Issue:9

    Topics: Animals; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Depressive Disorder; Female;

2017
Stellate ganglion block attenuates chronic stress induced depression in rats.
    PloS one, 2017, Volume: 12, Issue:8

    Topics: Adrenocorticotropic Hormone; Anesthetics, Local; Animals; Autonomic Nerve Block; bcl-2-Associated X

2017
Differential effects of imipramine and CORT118335 (Glucocorticoid receptor modulator/mineralocorticoid receptor antagonist) on brain-endocrine stress responses and depression-like behavior in female rats.
    Behavioural brain research, 2018, 01-15, Volume: 336

    Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behav

2018
Saikosaponin D relieves unpredictable chronic mild stress induced depressive-like behavior in rats: involvement of HPA axis and hippocampal neurogenesis.
    Psychopharmacology, 2017, Volume: 234, Issue:22

    Topics: Animals; Antidepressive Agents; Arousal; Corticosterone; Depression; Doublecortin Protein; Hippocamp

2017
Injection of oxytocin into paraventricular nucleus reverses depressive-like behaviors in the postpartum depression rat model.
    Behavioural brain research, 2018, 01-15, Volume: 336

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Depression, Postpartum

2018
Bifidobacterium pseudocatenulatum CECT 7765 Ameliorates Neuroendocrine Alterations Associated with an Exaggerated Stress Response and Anhedonia in Obese Mice.
    Molecular neurobiology, 2018, Volume: 55, Issue:6

    Topics: Adiposity; Anhedonia; Animals; Anxiety; Behavior, Animal; Bifidobacterium; Catecholamines; Corticost

2018
The BDNF Val66Met polymorphism regulates glucocorticoid-induced corticohippocampal remodeling and behavioral despair.
    Translational psychiatry, 2017, 09-19, Volume: 7, Issue:9

    Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Disease Mo

2017
Molecular changes associated with escitalopram response in a stress-based model of depression.
    Psychoneuroendocrinology, 2018, Volume: 87

    Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Citalopram; Corticosterone; Corticotrop

2018
Sex differences in behavioral and neurochemical effects of gonadectomy and aromatase inhibition in rats.
    Psychoneuroendocrinology, 2018, Volume: 87

    Topics: Animals; Antidepressive Agents; Aromatase; Aromatase Inhibitors; Behavior, Animal; Brain; Castration

2018
Agomelatine, venlafaxine, and running exercise effectively prevent anxiety- and depression-like behaviors and memory impairment in restraint stressed rats.
    PloS one, 2017, Volume: 12, Issue:11

    Topics: Acetamides; Animals; Antidepressive Agents, Second-Generation; Body Weight; Corticosterone; Depressi

2017
Role of Cyclooxygenase Inhibitors in Diminution of Dissimilar Stress-induced Depressive Behavior and Memory Impairment in Rats.
    Neuroscience, 2018, 02-01, Volume: 370

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biogenic Monoamines; Brain; Corticosterone; Cycloo

2018
Paroxetine blunts the corticosterone response to swim-induced stress and increases depressive-like behavior in a rat model of postpartum depression.
    Psychoneuroendocrinology, 2018, Volume: 89

    Topics: Animals; Corticosterone; Depression; Depression, Postpartum; Disease Models, Animal; Female; Male; P

2018
Regulation of actions and habits by ventral hippocampal trkB and adolescent corticosteroid exposure.
    PLoS biology, 2017, Volume: 15, Issue:11

    Topics: Adrenal Cortex Hormones; Animals; Behavior, Animal; Conditioning, Operant; Corticosterone; Depressio

2017
Seizure-induced activation of the HPA axis increases seizure frequency and comorbid depression-like behaviors.
    Epilepsy & behavior : E&B, 2018, Volume: 78

    Topics: Animals; Corticosterone; Corticotropin-Releasing Hormone; Depression; Depressive Disorder; Hypothala

2018
Combined corticosterone treatment and chronic restraint stress lead to depression associated with early cognitive deficits in mice.
    Metabolic brain disease, 2018, Volume: 33, Issue:2

    Topics: Animals; Behavior, Animal; Cognition Disorders; Cognitive Dysfunction; Corticosterone; Depression; D

2018
Therapeutic potential of silymarin in chronic unpredictable mild stress induced depressive-like behavior in mice.
    Journal of psychopharmacology (Oxford, England), 2018, Volume: 32, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Cerebral Cortex; Corticosterone; Depression; Disea

2018
Inability to suppress the stress-induced activation of the HPA axis during the peripartum period engenders deficits in postpartum behaviors in mice.
    Psychoneuroendocrinology, 2018, Volume: 90

    Topics: Animals; Behavior, Animal; Corticosterone; Corticotropin-Releasing Hormone; Depression; Depression,

2018
Antidepressant-like effects of water extract of Gastrodia elata Blume on neurotrophic regulation in a chronic social defeat stress model.
    Journal of ethnopharmacology, 2018, Apr-06, Volume: 215

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Body Weight; Corticosterone; Depression; Gastrodia

2018
ATP-sensitive potassium-channel inhibitor glibenclamide attenuates HPA axis hyperactivity, depression- and anxiety-related symptoms in a rat model of Alzheimer's disease.
    Brain research bulletin, 2018, Volume: 137

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anxiety; Corticosterone; Depression; Disease Mode

2018
Ocimum basilicum improve chronic stress-induced neurodegenerative changes in mice hippocampus.
    Metabolic brain disease, 2018, Volume: 33, Issue:3

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone;

2018
Blue light filtered white light induces depression-like responses and temporary spatial learning deficits in rats.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2018, Apr-18, Volume: 17, Issue:4

    Topics: Animals; Color; Corticosterone; Depression; Light; Male; Rats; Rats, Sprague-Dawley; Spatial Learnin

2018
sst
    Progress in neuro-psychopharmacology & biological psychiatry, 2018, 08-30, Volume: 86

    Topics: Aging; Animals; Anxiety; Chronic Disease; Cognition; Cognitive Dysfunction; Corticosterone; Depressi

2018
Preconception paternal bisphenol A exposure induces sex-specific anxiety and depression behaviors in adult rats.
    PloS one, 2018, Volume: 13, Issue:2

    Topics: Animals; Anxiety; Behavior, Animal; Benzhydryl Compounds; Corticosterone; Depression; Female; Male;

2018
Antidepressant-Like Effects of Vaccinium bracteatum in Chronic Restraint Stress Mice: Functional Actions and Mechanism Explorations.
    The American journal of Chinese medicine, 2018, Volume: 46, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Biogenic Monoamines; Brain; Cells, Cultured; Chron

2018
Long-term metabolic cage housing increases anxiety/depression-related behaviours in adult male rats.
    Archives of physiology and biochemistry, 2019, Volume: 125, Issue:2

    Topics: Animal Husbandry; Animals; Anxiety; Behavior, Animal; Blood Glucose; Corticosterone; Depression; Mal

2019
miR-124 antagonizes the antidepressant-like effects of standardized gypenosides in mice.
    Journal of psychopharmacology (Oxford, England), 2018, Volume: 32, Issue:4

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone;

2018
Repeated Neck Restraint Stress Bidirectionally Modulates Excitatory Transmission in the Dentate Gyrus and Performance in a Hippocampus-dependent Memory Task.
    Neuroscience, 2018, 05-21, Volume: 379

    Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Corticosterone; Dentate Gyrus; Depression; Excitatory

2018
Antidepressant effects of magnolol in a mouse model of depression induced by chronic corticosterone injection.
    Steroids, 2018, Volume: 135

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Biphenyl Compounds; Brain-Derived Neurotrophic Fac

2018
Perinatal exposure to venlafaxine leads to lower anxiety and depression-like behavior in the adult rat offspring.
    Behavioural pharmacology, 2018, Volume: 29, Issue:5

    Topics: Adrenal Cortex Hormones; Aldosterone; Animals; Animals, Newborn; Anxiety; Anxiety Disorders; Behavio

2018
Total Saikosaponins of Bupleurum yinchowense reduces depressive, anxiety-like behavior and increases synaptic proteins expression in chronic corticosterine-treated mice.
    BMC complementary and alternative medicine, 2018, Apr-02, Volume: 18, Issue:1

    Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Bupleurum; Corticosterone; Depression; Ma

2018
Magnolol abrogates chronic mild stress-induced depressive-like behaviors by inhibiting neuroinflammation and oxidative stress in the prefrontal cortex of mice.
    International immunopharmacology, 2018, Volume: 59

    Topics: Adrenocorticotropic Hormone; Animals; Anti-Inflammatory Agents; Antidepressive Agents; Behavior, Ani

2018
Elevated stress hormone levels and antidepressant treatment starting before pregnancy affect maternal care and litter characteristics in an animal model of depression.
    Behavioural brain research, 2018, 08-01, Volume: 348

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Depression, Postpartum

2018
Flotillin-1 interacts with the serotonin transporter and modulates chronic corticosterone response.
    Genes, brain, and behavior, 2019, Volume: 18, Issue:2

    Topics: Animals; Corticosterone; Depression; Female; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Prot

2019
Baicalin Modulates APPL2/Glucocorticoid Receptor Signaling Cascade, Promotes Neurogenesis, and Attenuates Emotional and Olfactory Dysfunctions in Chronic Corticosterone-Induced Depression.
    Molecular neurobiology, 2018, Volume: 55, Issue:12

    Topics: Adaptor Proteins, Signal Transducing; Animals; Anxiety; Behavior, Animal; Brain; Cell Line, Tumor; C

2018
Axonal transport proteins and depressive like behavior, following Chronic Unpredictable Mild Stress in male rat.
    Physiology & behavior, 2018, 10-01, Volume: 194

    Topics: Animals; Apoptosis; Axonal Transport; Cell Count; Corticosterone; Depression; Dyneins; Hippocampus;

2018
Liraglutide attenuates the depressive- and anxiety-like behaviour in the corticosterone induced depression model via improving hippocampal neural plasticity.
    Brain research, 2018, 09-01, Volume: 1694

    Topics: Alzheimer Disease; Animals; Antidepressive Agents; Anxiety; Corticosterone; Depression; Depressive D

2018
A novel PDE9 inhibitor WYQ-C36D ameliorates corticosterone-induced neurotoxicity and depression-like behaviors by cGMP-CREB-related signaling.
    CNS neuroscience & therapeutics, 2018, Volume: 24, Issue:10

    Topics: Animals; Cell Line, Transformed; Cognition Disorders; Corticosterone; CREB-Binding Protein; Cyclic G

2018
Neuroprotective evidence of alpha-lipoic acid and desvenlafaxine on memory deficit in a neuroendocrine model of depression.
    Naunyn-Schmiedeberg's archives of pharmacology, 2018, Volume: 391, Issue:8

    Topics: Acetylcholinesterase; Animals; Antidepressive Agents; Behavior, Animal; Brain; Corticosterone; Depre

2018
Targeting β-Catenin in GLAST-Expressing Cells: Impact on Anxiety and Depression-Related Behavior and Hippocampal Proliferation.
    Molecular neurobiology, 2019, Volume: 56, Issue:1

    Topics: Animals; Anxiety; Behavior, Animal; beta Catenin; Cell Cycle; Cell Proliferation; Corticosterone; De

2019
The effects of enriched environment on the behavioral and corticosterone response to methamphetamine in adolescent and adult mice.
    Developmental psychobiology, 2018, Volume: 60, Issue:6

    Topics: Age Factors; Animals; Anxiety; Behavior, Animal; Central Nervous System Stimulants; Corticosterone;

2018
Protective Effects of Crocetin on Depression-like Behavior Induced by Immobilization in Rat.
    CNS & neurological disorders drug targets, 2018, Volume: 17, Issue:5

    Topics: Animals; Antioxidants; Carotenoids; Corticosterone; Depression; Disease Models, Animal; Exploratory

2018
Effects of prenatal stress on anxiety- and depressive-like behaviours are sex-specific in prepubertal rats.
    Journal of neuroendocrinology, 2018, Volume: 30, Issue:7

    Topics: Animals; Anxiety; Behavior, Animal; Body Weight; Corticosterone; Depression; Female; Hypothalamo-Hyp

2018
The anxiolytic-like effects of ginsenoside Rg3 on chronic unpredictable stress in rats.
    Scientific reports, 2018, 05-17, Volume: 8, Issue:1

    Topics: Adrenocorticotropic Hormone; Animals; Anti-Anxiety Agents; Antineoplastic Agents, Phytogenic; Behavi

2018
High-fructose diet during adolescent development increases neuroinflammation and depressive-like behavior without exacerbating outcomes after stroke.
    Brain, behavior, and immunity, 2018, Volume: 73

    Topics: Age Factors; Animals; Behavior, Animal; Brain; Corticosterone; Depression; Diet, High-Fat; Disease M

2018
[Anti-depression mechanism of supercritical CO(2) extract from Compound Chaigui Fang based on network pharmacology].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2016, Volume: 51, Issue:3

    Topics: Animals; Antidepressive Agents; Computational Biology; Corticosterone; Depression; Disease Models, A

2016
The Lateral Habenula Directs Coping Styles Under Conditions of Stress via Recruitment of the Endocannabinoid System.
    Biological psychiatry, 2018, 10-15, Volume: 84, Issue:8

    Topics: Adaptation, Psychological; Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Corticosterone

2018
Sleep patterns deteriorate over time in chronic corticosterone-treated rats.
    Neuroscience letters, 2018, 08-24, Volume: 682

    Topics: Animals; Corticosterone; Depression; Drug Administration Schedule; Electroencephalography; Locus Coe

2018
Profiling changes in cortical astroglial cells following chronic stress.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018, Volume: 43, Issue:9

    Topics: Animals; Anxiety; Astrocytes; Chronic Disease; Corticosterone; Depression; Gene Expression; Glial Fi

2018
[Effects of chronic stress depression on the circadian rhythm of peripheral neuroendocrine hormone of rats].
    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2017, May-08, Volume: 33, Issue:5

    Topics: Animals; Circadian Rhythm; Corticosterone; Depression; Male; Melatonin; Random Allocation; Rats; Rat

2017
Social dominance predicts hippocampal glucocorticoid receptor recruitment and resilience to prenatal adversity.
    Scientific reports, 2018, 06-25, Volume: 8, Issue:1

    Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Hippocampus; Hypothalamo-Hypophyseal

2018
Regional alterations of cerebral [
    Journal of neural transmission (Vienna, Austria : 1996), 2018, Volume: 125, Issue:9

    Topics: Animals; Anxiety; Brain; Chronic Disease; Corticosterone; Depression; Disease Models, Animal; Fluori

2018
[Comparative study of the corticosterone and glutamate induced PC12 cells depression model by 1H NMR metabolomics].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2017, Volume: 52, Issue:2

    Topics: Animals; Antioxidants; Corticosterone; Depression; Depressive Disorder; Fatty Acids; Glutamic Acid;

2017
Cholecalciferol counteracts depressive-like behavior and oxidative stress induced by repeated corticosterone treatment in mice.
    European journal of pharmacology, 2018, Aug-15, Volume: 833

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Cholecalciferol; Corticosterone; Depression; Disea

2018
Acth-induced model of depression resistant to tricyclic antidepressants: Neuroendocrine and behavioral changes and influence of long-term magnesium administration.
    Hormones and behavior, 2018, Volume: 105

    Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Corticoste

2018
Riparin II ameliorates corticosterone-induced depressive-like behavior in mice: Role of antioxidant and neurotrophic mechanisms.
    Neurochemistry international, 2018, Volume: 120

    Topics: Animals; Antidepressive Agents; Antioxidants; Behavior, Animal; Benzamides; Brain-Derived Neurotroph

2018
Early life stress accelerates age-induced effects on neurogenesis, depression, and metabolic risk.
    Psychoneuroendocrinology, 2018, Volume: 96

    Topics: Age Factors; Animals; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Doubleco

2018
Comparative effects of stressors on behavioral and neuroimmune responses of fawn-hooded (FH/Wjd) and Wistar rats: Implications for models of depression.
    Journal of neuroimmunology, 2018, 09-15, Volume: 322

    Topics: Animals; Brain Chemistry; Corticosterone; Cytokines; Depression; Disease Models, Animal; Hypothalamo

2018
Glucocorticoid receptor activation induces decrease of hippocampal astrocyte number in rats.
    Psychopharmacology, 2018, Volume: 235, Issue:9

    Topics: Animals; Astrocytes; Cell Count; Corticosterone; Depression; Glucocorticoids; Hippocampus; Male; Mif

2018
Adiporon, an adiponectin receptor agonist acts as an antidepressant and metabolic regulator in a mouse model of depression.
    Translational psychiatry, 2018, 08-16, Volume: 8, Issue:1

    Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Corticosterone; Cytokines; Depression; Di

2018
Single administration of agmatine reverses the depressive-like behavior induced by corticosterone in mice: Comparison with ketamine and fluoxetine.
    Pharmacology, biochemistry, and behavior, 2018, Volume: 173

    Topics: Agmatine; Animals; Antidepressive Agents; Brain; Corticosterone; Depression; Disks Large Homolog 4 P

2018
Antioxidant and antidepressant-like effects of Eugenia catharinensis D. Legrand in an animal model of depression induced by corticosterone.
    Metabolic brain disease, 2018, Volume: 33, Issue:6

    Topics: Animals; Antidepressive Agents; Antioxidants; Corticosterone; Depression; Disease Models, Animal; Do

2018
Probiotics reduce risk-taking behavior in the Elevated Plus Maze in the Flinders Sensitive Line rat model of depression.
    Behavioural brain research, 2019, 02-01, Volume: 359

    Topics: Animals; Body Weight; Corticosterone; Depression; Dexamethasone; Drinking; Eating; Exploratory Behav

2019
Inhibition of Rho kinase by GSK 269962 reverses both corticosterone-induced detrusor overactivity and depression-like behaviour in rats.
    European journal of pharmacology, 2018, Oct-15, Volume: 837

    Topics: Animals; Brain-Derived Neurotrophic Factor; Corticosterone; Cytokines; Depression; Female; Imidazole

2018
Maternal separation induces anhedonia in female heterozygous serotonin transporter knockout rats.
    Behavioural brain research, 2019, 01-01, Volume: 356

    Topics: Anhedonia; Animals; Behavior, Animal; Brain; Corticosterone; Depression; Depressive Disorder; Hetero

2019
Chemical Constituents and Antidepressant-Like Effects in Ovariectomized Mice of the Ethanol Extract of
    Molecules (Basel, Switzerland), 2018, Aug-31, Volume: 23, Issue:9

    Topics: Amaranthaceae; Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor;

2018
The critical role of amygdala subnuclei in nociceptive and depressive-like behaviors in peripheral neuropathy.
    Scientific reports, 2018, 09-11, Volume: 8, Issue:1

    Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Basolateral Nuclear Complex; Central Amygdaloid Nucle

2018
Illuminated night alters hippocampal gene expressions and induces depressive-like responses in diurnal corvids.
    The European journal of neuroscience, 2018, Volume: 48, Issue:9

    Topics: Animals; Biomarkers; Brain-Derived Neurotrophic Factor; Circadian Rhythm; Corticosterone; Crows; Dep

2018
Standardized Citrus unshiu peel extract ameliorates dexamethasone-induced neurotoxicity and depressive-like behaviors in mice.
    Metabolic brain disease, 2018, Volume: 33, Issue:6

    Topics: Animals; Antidepressive Agents; Cell Line, Tumor; Cell Survival; Citrus; Corticosterone; Depression;

2018
Resveratrol and dimethyl fumarate ameliorate depression-like behaviour in a rat model of chronic unpredictable mild stress.
    Brain research, 2018, 12-15, Volume: 1701

    Topics: Animals; Antidepressive Agents; Antioxidants; Apoptosis; beta Catenin; Brain-Derived Neurotrophic Fa

2018
Depression-like behaviors induced by chronic corticosterone exposure via drinking water: Time-course analysis.
    Neuroscience letters, 2018, 11-20, Volume: 687

    Topics: Animals; Behavior, Animal; Corticosterone; Depression; Depressive Disorder; Disease Models, Animal;

2018
Melanin-Concentrating Hormone (MCH) and MCH-R1 in the Locus Coeruleus May Be Involved in the Regulation of Depressive-Like Behavior.
    The international journal of neuropsychopharmacology, 2018, 12-01, Volume: 21, Issue:12

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal

2018
Effect of chronic corticosterone-induced depression on circadian rhythms and age-related phenotypes in mice.
    Acta biochimica et biophysica Sinica, 2018, Dec-01, Volume: 50, Issue:12

    Topics: Age Factors; Aging; Animals; Behavior, Animal; Circadian Clocks; Circadian Rhythm; Corticosterone; D

2018
Agarwood Essential Oil Ameliorates Restrain Stress-Induced Anxiety and Depression by Inhibiting HPA Axis Hyperactivity.
    International journal of molecular sciences, 2018, Nov-05, Volume: 19, Issue:11

    Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Brain; Corticosterone; Corticotropin-Releasing Hormon

2018
Quantitative proteomics reveal antidepressant potential protein targets of xiaochaihutang in corticosterone induced model of depression.
    Journal of ethnopharmacology, 2019, Mar-01, Volume: 231

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Drugs, Chinese Herbal;

2019
Chronic histamine 3 receptor antagonism alleviates depression like conditions in mice via modulation of brain-derived neurotrophic factor and hypothalamus-pituitary adrenal axis.
    Psychoneuroendocrinology, 2019, Volume: 101

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain; Brain-Derived Neurotrophic Factor; Corticos

2019
Antidepressant effect of helicid in chronic unpredictable mild stress model in rats.
    International immunopharmacology, 2019, Volume: 67

    Topics: Animals; Antidepressive Agents; Benzaldehydes; Brain-Derived Neurotrophic Factor; Corticosterone; De

2019
Chronic adolescent stress sex-specifically alters central and peripheral neuro-immune reactivity in rats.
    Brain, behavior, and immunity, 2019, Volume: 76

    Topics: Age Factors; Animals; Anxiety; Anxiety Disorders; Central Nervous System; Corticosterone; Cytokines;

2019
Glucocorticoid receptor deletion from locus coeruleus norepinephrine neurons promotes depression-like social withdrawal in female but not male mice.
    Brain research, 2019, 05-01, Volume: 1710

    Topics: Animals; Antidepressive Agents; Brain; Corticosterone; Depression; Depressive Disorder; Dorsal Raphe

2019
Antidepressant-Like and Neuroprotective Effects of Ethanol Extract from the Root Bark of
    BioMed research international, 2018, Volume: 2018

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain; Brain-Derived Neurotrophic Factor; Cell Sur

2018
Effects of escitalopram and ibuprofen on a depression-like phenotype induced by chronic stress in rats.
    Neuroscience letters, 2019, 03-23, Volume: 696

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Citalopram; Cor

2019
Role of corticosterone in altered neurobehavioral responses to acute stress in a model of compromised hypothalamic-pituitary-adrenal axis function.
    Psychoneuroendocrinology, 2019, Volume: 102

    Topics: Animals; Anxiety; Anxiety Disorders; Corticosterone; Depression; Depressive Disorder; Disease Models

2019
Possible role of GLP-1 in antidepressant effects of metformin and exercise in CUMS mice.
    Journal of affective disorders, 2019, 03-01, Volume: 246

    Topics: Animals; Antidepressive Agents; bcl-2-Associated X Protein; Corticosterone; Depression; Depressive D

2019
Exposure to Patterned Auditory Stimuli during Acute Stress Prevents Despair-Like Behavior in Adult Mice That Were Previously Housed in an Enriched Environment in Combination with Auditory Stimuli.
    Neural plasticity, 2018, Volume: 2018

    Topics: Acoustic Stimulation; Animals; Corticosterone; Depression; Environment; Housing, Animal; Male; Mice;

2018
Antidepressive Effects of Taraxacum Officinale in a Mouse Model of Depression Are Due to Inhibition of Corticosterone Levels and Modulation of Mitogen-Activated Protein Kinase Phosphatase-1 (Mkp-1) and Brain-Derived Neurotrophic Factor (Bdnf) Expression.
    Medical science monitor : international medical journal of experimental and clinical research, 2019, Jan-13, Volume: 25

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone;

2019
Oxytocin administration prevents cellular aging caused by social isolation.
    Psychoneuroendocrinology, 2019, Volume: 103

    Topics: Anhedonia; Animals; Arvicolinae; Cellular Senescence; Corticosterone; Depression; Female; Glucocorti

2019
Beneficial Effects of Physical Activity and Crocin Against Adolescent Stress Induced Anxiety or Depressive-Like Symptoms and Dendritic Morphology Remodeling in Prefrontal Cortex in Adult Male Rats.
    Neurochemical research, 2019, Volume: 44, Issue:4

    Topics: Animals; Anxiety; Carotenoids; Combined Modality Therapy; Corticosterone; Dendrites; Depression; Mal

2019
Antidepressant activities of escitalopram and blonanserin on prenatal and adolescent combined stress-induced depression model: Possible role of neurotrophic mechanism change in serum and nucleus accumbens.
    Journal of affective disorders, 2019, 03-15, Volume: 247

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Citalopram; Cor

2019
Antidepressant-like activities of live and heat-killed Lactobacillus paracasei PS23 in chronic corticosterone-treated mice and possible mechanisms.
    Brain research, 2019, 05-15, Volume: 1711

    Topics: Animals; Antidepressive Agents; Anxiety; Anxiety Disorders; Behavior, Animal; Brain; Corticosterone;

2019
Selective vulnerability of dorsal raphe-medial prefrontal cortex projection neurons to corticosterone-induced hypofunction.
    The European journal of neuroscience, 2019, Volume: 50, Issue:1

    Topics: Animals; Corticosterone; Depression; Dorsal Raphe Nucleus; Excitatory Postsynaptic Potentials; Genic

2019
DNA methylation of the Tacr2 gene in a CUMS model of depression.
    Behavioural brain research, 2019, 06-03, Volume: 365

    Topics: Animals; Body Weight; Corticosterone; Corticotropin-Releasing Hormone; Depression; Depressive Disord

2019
PINK1 deficiency is associated with increased deficits of adult hippocampal neurogenesis and lowers the threshold for stress-induced depression in mice.
    Behavioural brain research, 2019, 05-02, Volume: 363

    Topics: Animals; Anxiety; Anxiety Disorders; Behavior, Animal; Cell Differentiation; Cell Proliferation; Cor

2019
Tactile Stimulation on Adulthood Modifies the HPA Axis, Neurotrophic Factors, and GFAP Signaling Reverting Depression-Like Behavior in Female Rats.
    Molecular neurobiology, 2019, Volume: 56, Issue:9

    Topics: Adrenocorticotropic Hormone; Aging; Animals; Behavior, Animal; Body Weight; Corticosterone; Depressi

2019
PET imaging of the mouse brain reveals a dynamic regulation of SERT density in a chronic stress model.
    Translational psychiatry, 2019, 02-11, Volume: 9, Issue:1

    Topics: Aniline Compounds; Animals; Brain; Corticosterone; Depression; Female; Male; Mice, Inbred C57BL; Mic

2019
Ketamine improved depressive-like behaviors via hippocampal glucocorticoid receptor in chronic stress induced- susceptible mice.
    Behavioural brain research, 2019, 05-17, Volume: 364

    Topics: Animals; Anxiety; Corticosterone; Depression; Depressive Disorder; Disease Models, Animal; Gene Expr

2019
Lutein prevents corticosterone-induced depressive-like behavior in mice with the involvement of antioxidant and neuroprotective activities.
    Pharmacology, biochemistry, and behavior, 2019, Volume: 179

    Topics: Animals; Antioxidants; Behavior, Animal; Corticosterone; Depression; Fluoxetine; Lutein; Male; Mice;

2019
Acute corticosterone treatment elicits antidepressant-like actions on the hippocampal 5-HT and the immobility phenotype.
    Brain research, 2019, 07-01, Volume: 1714

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain; Brain-Derived Neurotrophic Factor; Corticos

2019
Effects of conditioned social fear on ethanol drinking and vice-versa in male mice.
    Psychopharmacology, 2019, Volume: 236, Issue:7

    Topics: Alcohol Drinking; Animals; Anxiety; Corticosterone; Depression; Ethanol; Fear; Interpersonal Relatio

2019
Lavender essential oil ameliorates depression-like behavior and increases neurogenesis and dendritic complexity in rats.
    Neuroscience letters, 2019, 05-14, Volume: 701

    Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Dendrites; Depression; Doublecortin Protein; Lav

2019
Developmental outcomes after gestational antidepressant treatment with sertraline and its discontinuation in an animal model of maternal depression.
    Behavioural brain research, 2019, 07-02, Volume: 366

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Depressive Disorder; D

2019
Decreased stress-induced depression-like behavior in lactating rats is associated with changes in the hypothalamic-pituitary-adrenal axis, brain monoamines, and brain amino acid metabolism.
    Stress (Amsterdam, Netherlands), 2019, Volume: 22, Issue:4

    Topics: Adrenocorticotropic Hormone; Amino Acids; Animals; Brain; Catecholamines; Corticosterone; Depression

2019
Faecalibacterium prausnitzii (ATCC 27766) has preventive and therapeutic effects on chronic unpredictable mild stress-induced depression-like and anxiety-like behavior in rats.
    Psychoneuroendocrinology, 2019, Volume: 104

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Anxiety Disorders; Behavior, Animal; Bone Density; Brain; Bra

2019
The internal link of serum steroid hormones levels in insomnia, depression, and Alzheimer's disease rats: Is there an effective way to distinguish among these three diseases based on potential biomarkers?
    Journal of separation science, 2019, Volume: 42, Issue:10

    Topics: Alzheimer Disease; Animals; Bayes Theorem; Biomarkers; Calibration; Chromatography, High Pressure Li

2019
Protocatechuic acid attenuate depressive-like behavior in olfactory bulbectomized rat model: behavioral and neurobiochemical investigations.
    Metabolic brain disease, 2019, Volume: 34, Issue:3

    Topics: Animals; Antidepressive Agents; Antioxidants; Behavior, Animal; Corticosterone; Depression; Disease

2019
Effects of corticosterone on the expression of mature brain-derived neurotrophic factor (mBDNF) and proBDNF in the hippocampal dentate gyrus.
    Behavioural brain research, 2019, 06-03, Volume: 365

    Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Corticosterone; Dentate Gyrus; De

2019
Effects of a selanylimidazopyridine on the acute restraint stress-induced depressive- and anxiety-like behaviors and biological changes in mice.
    Behavioural brain research, 2019, 07-02, Volume: 366

    Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Animal; Brain-Derived Neurot

2019
    Beneficial microbes, 2019, Apr-19, Volume: 10, Issue:4

    Topics: Animals; Animals, Newborn; Anxiety; Corticosterone; Cytokines; Depression; Disease Models, Animal; F

2019
Quercetin mitigates anxiety-like behavior and normalizes hypothalamus-pituitary-adrenal axis function in a mouse model of mild traumatic brain injury.
    Behavioural pharmacology, 2019, Volume: 30, Issue:2 and 3-Sp

    Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Anxiety Disorders; Brain Concussion; Corticosterone;

2019
Stress-induced neural activation is altered during early withdrawal from chronic methamphetamine.
    Behavioural brain research, 2019, 07-02, Volume: 366

    Topics: Animals; Anxiety; Brain; CA3 Region, Hippocampal; Central Nervous System Stimulants; Corticosterone;

2019
Reversal effect of Riparin IV in depression and anxiety caused by corticosterone chronic administration in mice.
    Pharmacology, biochemistry, and behavior, 2019, Volume: 180

    Topics: Amides; Anhedonia; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Animal; B

2019
Comparative pharmacokinetic study of four major bioactive components after oral administration of Zhi-Zi-Hou-Po decoction in normal and corticosterone-induced depressive rats.
    Biomedical chromatography : BMC, 2019, Volume: 33, Issue:9

    Topics: Administration, Oral; Animals; Biphenyl Compounds; Corticosterone; Depression; Disease Models, Anima

2019
The Chinese Herbal Formula PAPZ Ameliorates Behavioral Abnormalities in Depressive Mice.
    Nutrients, 2019, Apr-16, Volume: 11, Issue:4

    Topics: Angelica sinensis; Animals; Antidepressive Agents; Antioxidants; Behavior, Animal; Brain-Derived Neu

2019
Transcriptome profiles of corticosterone-induced cytotoxicity reveals the involvement of neurite growth-related genes in depression.
    Psychiatry research, 2019, Volume: 276

    Topics: Animals; Anti-Inflammatory Agents; Cell Survival; Corticosterone; Depression; Male; Neurites; Neurog

2019
Resilience to chronic stress is associated with specific neurobiological, neuroendocrine and immune responses.
    Brain, behavior, and immunity, 2019, Volume: 80

    Topics: Adaptation, Psychological; Animals; Anxiety; Behavior, Animal; Corticosterone; Corticotropin-Releasi

2019
A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice.
    Journal of visualized experiments : JoVE, 2019, 05-15, Issue:147

    Topics: Animals; Behavior, Animal; Corticosterone; Depression; Diet; Disease Models, Animal; Glutamine; Male

2019
Depression comorbid with hyperalgesia: Different roles of neuroinflammation induced by chronic stress and hypercortisolism.
    Journal of affective disorders, 2019, 09-01, Volume: 256

    Topics: Adrenocorticotropic Hormone; Animals; Corticosterone; Depression; Disease Models, Animal; Hippocampu

2019
Effects of Chrysin on Serum Corticosterone Levels and Brain Oxidative Damages Induced by Immobilization in Rat.
    Cardiovascular & hematological disorders drug targets, 2020, Volume: 20, Issue:1

    Topics: Animals; Brain; Corticosterone; Depression; Flavonoids; Immobilization; Male; Oxidation-Reduction; O

2020
Chronic stress induces hypersensitivity of murine gastric vagal afferents.
    Neurogastroenterology and motility, 2019, Volume: 31, Issue:12

    Topics: Afferent Pathways; Animals; Anxiety; Blood Glucose; Chronic Disease; Corticosterone; Depression; Exp

2019
Mitochondrial signaling in inflammation-induced depressive behavior in female and male rats: The role of glucocorticoid receptor.
    Brain research bulletin, 2019, Volume: 150

    Topics: Animals; Apoptosis; Corticosterone; Depression; Depressive Disorder, Major; Female; Hypothalamo-Hypo

2019
Glucocorticoid receptor antagonism prevents microglia-mediated neuronal remodeling and behavioral despair following chronic unpredictable stress.
    Brain, behavior, and immunity, 2019, Volume: 81

    Topics: Animals; Behavior, Animal; Brain; Corticosterone; Depression; Hippocampus; Macrophage Colony-Stimula

2019
Antidepressant-like effects of dietary gardenia blue pigment derived from genipin and tyrosine.
    Food & function, 2019, Aug-01, Volume: 10, Issue:8

    Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Garde

2019
Increased Homer1-mGluR5 mediates chronic stress-induced depressive-like behaviors and glutamatergic dysregulation via activation of PERK-eIF2α.
    Progress in neuro-psychopharmacology & biological psychiatry, 2019, 12-20, Volume: 95

    Topics: Animals; Behavior, Animal; Corticosterone; Depression; Eukaryotic Initiation Factor-2; Excitatory Am

2019
Exposure to jet lag aggravates depression-like behaviors and age-related phenotypes in rats subject to chronic corticosterone.
    Acta biochimica et biophysica Sinica, 2019, Aug-05, Volume: 51, Issue:8

    Topics: Aging; Animals; Behavior, Animal; Corticosterone; Cyclooxygenase 1; Depression; Jet Lag Syndrome; Li

2019
Edaravone presents antidepressant-like activity in corticosterone model of depression in mice with possible role of Fkbp5, Comt, Adora1 and Slc6a15 genes.
    Toxicology and applied pharmacology, 2019, 10-01, Volume: 380

    Topics: Amino Acid Transport Systems, Neutral; Animals; Antidepressive Agents; Behavior, Animal; Catechol O-

2019
Antidepressant-like effects of 20(S)-protopanaxadiol in a mouse model of chronic social defeat stress and the related mechanisms.
    Phytotherapy research : PTR, 2019, Volume: 33, Issue:10

    Topics: Animals; Antidepressive Agents; Chronic Disease; Corticosterone; Depression; Disease Models, Animal;

2019
Roman chamomile inhalation combined with clomipramine treatment improves treatment-resistant depression-like behavior in mice.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 118

    Topics: Animals; Behavior, Animal; Cell Proliferation; Chamaemelum; Clomipramine; Corticosterone; Cytokines;

2019
The effect of fluoxetine on astrocyte autophagy flux and injured mitochondria clearance in a mouse model of depression.
    Cell death & disease, 2019, 08-02, Volume: 10, Issue:8

    Topics: Animals; Antidepressive Agents; Astrocytes; Autophagosomes; Autophagy; Corticosterone; Depression; D

2019
Effect of co-treatment with fluoxetine or mirtazapine and risperidone on the active behaviors and plasma corticosterone concentration in rats subjected to the forced swim test.
    Pharmacological reports : PR, 2012, Volume: 64, Issue:6

    Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Antipsychotic A

2012
Glucocorticoids orchestrate divergent effects on mood through adult neurogenesis.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, Feb-13, Volume: 33, Issue:7

    Topics: Adaptation, Psychological; Adrenalectomy; Affect; Animals; Antimetabolites; Behavior, Animal; Bromod

2013
Prenatal exposure to escitalopram and/or stress in rats: a prenatal stress model of maternal depression and its treatment.
    Psychopharmacology, 2013, Volume: 228, Issue:2

    Topics: Animals; Citalopram; Corticosterone; Darkness; Depression; Disease Models, Animal; Female; Infusion

2013
[Antidepressant activities of flavonoids from Glycyrrhiza uralensis and its neurogenesis protective effect in rats].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2012, Volume: 47, Issue:12

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bromodeoxyuridine; Corticosterone; Depression; Fla

2012
Antidepressant-like effect of macranthol isolated from Illicium dunnianum tutch in mice.
    European journal of pharmacology, 2013, May-05, Volume: 707, Issue:1-3

    Topics: Alkenes; Animals; Antidepressive Agents; Corticosterone; Depression; Disease Models, Animal; Dose-Re

2013
Augmentation therapy with alpha-lipoic acid and desvenlafaxine: a future target for treatment of depression?
    Naunyn-Schmiedeberg's archives of pharmacology, 2013, Volume: 386, Issue:8

    Topics: Animals; Antidepressive Agents; Antioxidants; Behavior, Animal; Corticosterone; Cyclohexanols; Depre

2013
Suppression of neuroinflammatory and apoptotic signaling cascade by curcumin alone and in combination with piperine in rat model of olfactory bulbectomy induced depression.
    PloS one, 2013, Volume: 8, Issue:4

    Topics: Alkaloids; Animals; Apoptosis; Benzodioxoles; Brain; Brain-Derived Neurotrophic Factor; Caspase 3; C

2013
Imbalance of leptin pathway and hypothalamus synaptic plasticity markers are associated with stress-induced depression in rats.
    Behavioural brain research, 2013, Jul-15, Volume: 249

    Topics: Animals; Biomarkers; Corticosterone; Depression; Hypothalamo-Hypophyseal System; Hypothalamus; Lepti

2013
Behavioral deficits, abnormal corticosterone, and reduced prefrontal metabolites of adolescent rats subject to early life stress.
    Neuroscience letters, 2013, Jun-17, Volume: 545

    Topics: Aging; Animals; Corticosterone; Depression; Female; Male; Maternal Deprivation; Mental Disorders; Pr

2013
[Effect of hesperidin on behavior and HPA axis of rat model of chronic stress-induced depression].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2013, Volume: 38, Issue:2

    Topics: Administration, Oral; Animals; Behavior, Animal; Corticosterone; Corticotropin-Releasing Hormone; De

2013
Role of prefrontal cortex glucocorticoid receptors in stress and emotion.
    Biological psychiatry, 2013, Nov-01, Volume: 74, Issue:9

    Topics: Adrenocorticotropic Hormone; Affect; Animals; Cells, Cultured; Corticosterone; Depression; Emotions;

2013
Neonatal NMDA receptor blockade alters anxiety- and depression-related behaviors in a sex-dependent manner in mice.
    Neuropharmacology, 2013, Volume: 73

    Topics: Age Factors; Animals; Animals, Newborn; Anxiety; Behavior, Animal; Body Weight; Corticosterone; Depr

2013
Disruption of circadian rhythms due to chronic constant light leads to depressive and anxiety-like behaviors in the rat.
    Behavioural brain research, 2013, Sep-01, Volume: 252

    Topics: Analysis of Variance; Animals; Anxiety; Body Weight; Cell Count; Chronobiology Disorders; Corticoste

2013
The effects of a standardized Acanthopanax koreanum extract on stress-induced behavioral alterations in mice.
    Journal of ethnopharmacology, 2013, Jul-30, Volume: 148, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Animal; Corticosterone; Depr

2013
Being suckled in a large litter mitigates the effects of early-life stress on hypothalamic-pituitary-adrenal axis function in the male rat.
    Journal of neuroendocrinology, 2013, Volume: 25, Issue:9

    Topics: Animals; Anxiety; Body Composition; Body Weight; Corticosterone; Depression; Female; Hypothalamo-Hyp

2013
Depression-like behavior in subclinical hypothyroidism rat induced by hemi-thyroid electrocauterization.
    Endocrine, 2014, Volume: 45, Issue:3

    Topics: Adrenal Cortex; Animals; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Elect

2014
Differential impact of a complex environment on positive affect in an animal model of individual differences in emotionality.
    Neuroscience, 2013, Sep-17, Volume: 248

    Topics: Affect; Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Envi

2013
Orcinol glucoside produces antidepressant effects by blocking the behavioural and neuronal deficits caused by chronic stress.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2014, Volume: 24, Issue:1

    Topics: Animals; Antidepressive Agents; Chronic Disease; Corticosterone; Corticotropin-Releasing Hormone; De

2014
Systematic correlation between spine plasticity and the anxiety/depression-like phenotype induced by corticosterone in mice.
    Neuroreport, 2013, Aug-21, Volume: 24, Issue:12

    Topics: Animals; Antidepressive Agents; Behavior, Animal; CA1 Region, Hippocampal; Corticosterone; Dendritic

2013
Mood and memory function in ovariectomised rats exposed to social instability stress.
    BioMed research international, 2013, Volume: 2013

    Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Corticosterone; Depression; Estradiol; Memory; Ovarie

2013
Effects of palmitoylethanolamide and luteolin in an animal model of anxiety/depression.
    CNS & neurological disorders drug targets, 2013, Volume: 12, Issue:7

    Topics: Amides; Animals; Antidepressive Agents; Anxiety; Apoptosis; Behavior, Animal; Brain; Brain-Derived N

2013
Effects of corticosterone and amyloid-beta on proteins essential for synaptic function: implications for depression and Alzheimer's disease.
    Biochimica et biophysica acta, 2013, Volume: 1832, Issue:12

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Anti-Inflammatory Agents; Autophagy; Blotting, Western; Ce

2013
Zinc deficiency alters responsiveness to antidepressant drugs in mice.
    Pharmacological reports : PR, 2013, Volume: 65, Issue:3

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Diet; Disease Models,

2013
Inactivation of glucocorticoid receptor in noradrenergic system influences anxiety- and depressive-like behavior in mice.
    PloS one, 2013, Volume: 8, Issue:8

    Topics: Adrenergic Neurons; Animals; Anxiety Disorders; Behavior, Animal; Chronic Disease; Corticosterone; D

2013
Anxiety- and depression-like behavior are correlated with leptin and leptin receptor expression in prefrontal cortex of streptozotocin-induced diabetic rats.
    Biotechnic & histochemistry : official publication of the Biological Stain Commission, 2014, Volume: 89, Issue:3

    Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Diabetes Mellitus, Experimental; Dis

2014
High novelty-seeking rats are resilient to negative physiological effects of the early life stress.
    Stress (Amsterdam, Netherlands), 2014, Volume: 17, Issue:1

    Topics: Adrenocorticotropic Hormone; Animals; Animals, Newborn; Anxiety; Behavior, Animal; Corticosterone; D

2014
Female rats exposed to stress and alcohol show impaired memory and increased depressive-like behaviors.
    Physiology & behavior, 2014, Jan-17, Volume: 123

    Topics: Alcohols; Analysis of Variance; Animals; Body Weight; Corticosterone; Depression; Disease Models, An

2014
Estradiol decreases rat depressive behavior by estrogen receptor beta but not alpha: no correlation with plasma corticosterone.
    Neuroreport, 2014, Jan-22, Volume: 25, Issue:2

    Topics: Animals; Corticosterone; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Estra

2014
Antidepressant-like effects of the aqueous macerate of the bulb of Gladiolus dalenii Van Geel (Iridaceae) in a rat model of epilepsy-associated depression.
    BMC complementary and alternative medicine, 2013, Oct-20, Volume: 13

    Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Epile

2013
Disruption of social bonds induces behavioral and physiological dysregulation in male and female prairie voles.
    Autonomic neuroscience : basic & clinical, 2014, Volume: 180

    Topics: Adrenocorticotropic Hormone; Animals; Arvicolinae; Atenolol; Atropine; Autonomic Nervous System; Ber

2014
Antidepressant-like activity of turmerone in behavioral despair tests in mice.
    BMC complementary and alternative medicine, 2013, Nov-01, Volume: 13

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Curcuma; Depression; Drugs, Chines

2013
Agmatine attenuates chronic unpredictable mild stress induced behavioral alteration in mice.
    European journal of pharmacology, 2013, Nov-15, Volume: 720, Issue:1-3

    Topics: Agmatine; Animals; Antidepressive Agents; Behavior, Animal; Body Weight; Corticosterone; Depression;

2013
[Mifepristone repairs alteration of learning and memory abilities in rat model of depression].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2013, Volume: 48, Issue:8

    Topics: Animals; Behavior, Animal; Corticosterone; Depression; Hippocampus; Learning; Male; Memory; Mifepris

2013
The effect of chronic administration of corticosterone on anxiety- and depression-like behavior and the expression of GABA-A receptor alpha-2 subunits in brain structures of low- and high-anxiety rats.
    Hormones and behavior, 2014, Volume: 65, Issue:1

    Topics: Amygdala; Animals; Anxiety; Behavior, Animal; Brain Chemistry; Corticosterone; Depression; Emotions;

2014
An organoselenium compound improves behavioral, endocrinal and neurochemical changes induced by corticosterone in mice.
    Psychopharmacology, 2014, Volume: 231, Issue:10

    Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Disease

2014
Strain-dependent effects of prenatal maternal immune activation on anxiety- and depression-like behaviors in offspring.
    Brain, behavior, and immunity, 2014, Volume: 37

    Topics: Animals; Animals, Outbred Strains; Anxiety; Corticosterone; Depression; Female; Interleukin-6; Lipop

2014
All-trans retinoic acid-induced hypothalamus-pituitary-adrenal hyperactivity involves glucocorticoid receptor dysregulation.
    Translational psychiatry, 2013, Dec-17, Volume: 3

    Topics: Animals; Behavior, Animal; Corticosterone; Corticotropin-Releasing Hormone; Depression; Dexamethason

2013
Depression-like behaviors in mice subjected to co-treatment of high-fat diet and corticosterone are ameliorated by AICAR and exercise.
    Journal of affective disorders, 2014, Volume: 156

    Topics: Aminoimidazole Carboxamide; Animals; Corticosterone; Depression; Depressive Disorder; Diet, High-Fat

2014
Tumor necrosis factor-alpha during neonatal brain development affects anxiety- and depression-related behaviors in adult male and female mice.
    Behavioural brain research, 2014, Mar-15, Volume: 261

    Topics: Animals; Animals, Newborn; Anxiety; Body Weight; Brain; Corticosterone; Cytokines; Dark Adaptation;

2014
Urtica dioica extract attenuates depressive like behavior and associative memory dysfunction in dexamethasone induced diabetic mice.
    Metabolic brain disease, 2014, Volume: 29, Issue:1

    Topics: Animals; Antidepressive Agents; Association Learning; Avoidance Learning; Blood Glucose; Corticoster

2014
Soyo-san reduces depressive-like behavior and proinflammatory cytokines in ovariectomized female rats.
    BMC complementary and alternative medicine, 2014, Jan-21, Volume: 14

    Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents; Brain; Corticosterone; Cytokines; Depressi

2014
Chronic unpredictable mild stress impairs erythrocyte immune function and changes T-lymphocyte subsets in a rat model of stress-induced depression.
    Environmental toxicology and pharmacology, 2014, Volume: 37, Issue:1

    Topics: Animals; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Drinking; Erythrocyte

2014
Loss of Gabrd in CRH neurons blunts the corticosterone response to stress and diminishes stress-related behaviors.
    Psychoneuroendocrinology, 2014, Volume: 41

    Topics: Animals; Anxiety; Behavior, Animal; Brain; Corticosterone; Corticotropin-Releasing Hormone; Depressi

2014
Maternal separation modifies behavioural and neuroendocrine responses to stress in CCR7 deficient mice.
    Behavioural brain research, 2014, Apr-15, Volume: 263

    Topics: Animals; Animals, Newborn; Anxiety; Body Weight; Corticosterone; Depression; Exploratory Behavior; F

2014
Hippocampal dysfunctions in tumor-bearing mice.
    Brain, behavior, and immunity, 2014, Volume: 36

    Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Line, Tumor; Corticosterone; Cyclooxygenase 2; Cyto

2014
Enhancement of BDNF concentration and restoration of the hypothalamic-pituitary-adrenal axis accompany reduced depressive-like behaviour in stressed ovariectomised rats treated with either Tualang honey or estrogen.
    TheScientificWorldJournal, 2014, Volume: 2014

    Topics: Adrenocorticotropic Hormone; Animals; Behavior, Animal; Body Weight; Brain-Derived Neurotrophic Fact

2014
A neuroendocrine mechanism of co-morbidity of depression-like behavior and myocardial injury in rats.
    PloS one, 2014, Volume: 9, Issue:2

    Topics: Animals; Apoptosis; Body Weight; Cardiomyopathies; Cells, Cultured; Comorbidity; Corticosterone; Dep

2014
Mice deficient in phosphodiesterase-4A display anxiogenic-like behavior.
    Psychopharmacology, 2014, Volume: 231, Issue:15

    Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Cyclic Nucleotide Phosphodiesterases, Type 4; De

2014
Effects of brief pulse and ultrabrief pulse electroconvulsive stimulation on rodent brain and behaviour in the corticosterone model of depression.
    The international journal of neuropsychopharmacology, 2014, Volume: 17, Issue:9

    Topics: Adrenal Glands; Analysis of Variance; Animals; Anti-Inflammatory Agents; Body Weight; Brain-Derived

2014
Iptakalim confers an antidepressant effect in a chronic mild stress model of depression through regulating neuro-inflammation and neurogenesis.
    The international journal of neuropsychopharmacology, 2014, Volume: 17, Issue:9

    Topics: Animals; Antidepressive Agents; Body Weight; Bromodeoxyuridine; Cell Count; Corticosterone; Cytokine

2014
Antidepressant and anxiolytic profiles of newly synthesized arginine vasopressin V1B receptor antagonists: TASP0233278 and TASP0390325.
    British journal of pharmacology, 2014, Volume: 171, Issue:14

    Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Antidepressive Agents; Antidiuretic Hormone Rece

2014
Glucocorticoid receptor deletion from the dorsal raphé nucleus of mice reduces dysphoria-like behavior and impairs hypothalamic-pituitary-adrenocortical axis feedback inhibition.
    The European journal of neuroscience, 2014, Volume: 39, Issue:10

    Topics: Adaptation, Psychological; Animals; Anxiety; Circadian Rhythm; Corticosterone; Depression; Dominance

2014
Social defeat stress induces a depression-like phenotype in adolescent male c57BL/6 mice.
    Stress (Amsterdam, Netherlands), 2014, Volume: 17, Issue:3

    Topics: Aging; Animals; Anxiety; Corticosterone; Depression; Depressive Disorder; Dietary Carbohydrates; Dom

2014
Protracted effects of juvenile stressor exposure are mitigated by access to palatable food.
    PloS one, 2014, Volume: 9, Issue:5

    Topics: Adiposity; Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Diet, High-Fat; Energy In

2014
Enkephalin knockout male mice are resistant to chronic mild stress.
    Genes, brain, and behavior, 2014, Volume: 13, Issue:6

    Topics: Animals; Anxiety; Corticosterone; Depression; Enkephalins; Hypothalamus; Male; Maze Learning; Mice;

2014
The effects of neonatal cryoanaesthesia-induced hypothermia on adult emotional behaviour and stress markers in C57BL/6 mice.
    Behavioural brain research, 2014, Aug-15, Volume: 270

    Topics: Aging; Animals; Animals, Newborn; Anxiety; Biomarkers; Brain-Derived Neurotrophic Factor; Corticoste

2014
Long-term effects of controllability or the lack of it on coping abilities and stress resilience in the rat.
    Stress (Amsterdam, Netherlands), 2014, Volume: 17, Issue:5

    Topics: Adaptation, Psychological; Animals; Anxiety; Avoidance Learning; Behavior, Animal; Corticosterone; D

2014
Witnessing traumatic events causes severe behavioral impairments in rats.
    The international journal of neuropsychopharmacology, 2014, Volume: 17, Issue:12

    Topics: Animals; Anxiety; Corticosterone; Depression; Disease Models, Animal; Dominance-Subordination; Housi

2014
Pycnogenol ameliorates depression-like behavior in repeated corticosterone-induced depression mice model.
    BioMed research international, 2014, Volume: 2014

    Topics: Animals; Antioxidants; Corticosterone; Depression; Depressive Disorder; Disease Models, Animal; Flav

2014
Long-term differential effects of chronic young-adult corticosterone exposure on anxiety and depression-like behaviour in BDNF heterozygous rats depend on the experimental paradigm used.
    Neuroscience letters, 2014, Jul-25, Volume: 576

    Topics: Animals; Anxiety; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Genotype; Heterozyg

2014
5HT3 receptor antagonist (ondansetron) reverses depressive behavior evoked by chronic unpredictable stress in mice: modulation of hypothalamic-pituitary-adrenocortical and brain serotonergic system.
    Pharmacology, biochemistry, and behavior, 2014, Volume: 124

    Topics: Adrenal Cortex; Animals; Behavior, Animal; Brain; Corticosterone; Depression; Hypothalamo-Hypophysea

2014
Simvastatin treatment exerts antidepressant-like effect in rats exposed to chronic mild stress.
    Pharmacology, biochemistry, and behavior, 2014, Volume: 124

    Topics: Animals; Behavior, Animal; Corticosterone; Depression; Hydroxymethylglutaryl-CoA Reductase Inhibitor

2014
Emodin opposes chronic unpredictable mild stress induced depressive-like behavior in mice by upregulating the levels of hippocampal glucocorticoid receptor and brain-derived neurotrophic factor.
    Fitoterapia, 2014, Volume: 98

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone;

2014
Neuropathic pain-induced depressive-like behavior and hippocampal neurogenesis and plasticity are dependent on TNFR1 signaling.
    Brain, behavior, and immunity, 2014, Volume: 41

    Topics: Anhedonia; Animals; Corticosterone; Depression; Drinking Behavior; Exploratory Behavior; Food Prefer

2014
Correlations between depression behaviors and sleep parameters after repeated corticosterone injections in rats.
    Acta pharmacologica Sinica, 2014, Volume: 35, Issue:7

    Topics: Animals; Corticosterone; Depression; Male; Rats; Rats, Sprague-Dawley; Sleep; Sleep Wake Disorders;

2014
Possible involvement of corticosterone and serotonin in antidepressant and antianxiety effects of chromium picolinate in chronic unpredictable mild stress induced depression and anxiety in rats.
    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2015, Volume: 29

    Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Brain; Chronic Disease; Corticosterone

2015
Development of behavioral and hormonal disorders in prenatally stressed female rats on the model of posttraumatic stress disorder.
    Bulletin of experimental biology and medicine, 2014, Volume: 157, Issue:3

    Topics: Animals; Anxiety; Corticosterone; Depression; Female; Pregnancy; Prenatal Exposure Delayed Effects;

2014
Brain organic cation transporter 2 controls response and vulnerability to stress and GSK3β signaling.
    Molecular psychiatry, 2015, Volume: 20, Issue:7

    Topics: Action Potentials; Acute Disease; Animals; Brain; Chronic Disease; Corticosterone; Depression; Glyco

2015
Behavioral effects of glucocorticoids during the first exposures to the forced swim stress.
    Psychopharmacology, 2015, Volume: 232, Issue:5

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Dexamethasone; Enzyme

2015
Chronic high-fat diet increases acute neuroendocrine stress response independently of prenatal dexamethasone treatment in male rats.
    Acta neuropsychiatrica, 2014, Volume: 26, Issue:1

    Topics: Animals; Blood Glucose; Corticosterone; Depression; Dexamethasone; Diet, High-Fat; Disease Models, A

2014
The antidepressant effects of ginseng total saponins in male C57BL/6N mice by enhancing hippocampal inhibitory phosphorylation of GSK-3β.
    Phytotherapy research : PTR, 2014, Volume: 28, Issue:7

    Topics: Animals; Antidepressive Agents; Corticosterone; Depression; Disease Models, Animal; Down-Regulation;

2014
Prevention of 5-hydroxytryptamine2C receptor RNA editing and alternate splicing in C57BL/6 mice activates the hypothalamic-pituitary-adrenal axis and alters mood.
    The European journal of neuroscience, 2014, Volume: 40, Issue:11

    Topics: Affect; Alternative Splicing; Animals; Circadian Rhythm; Corticosterone; Corticotropin-Releasing Hor

2014
Lipopolysaccharide repeated challenge followed by chronic mild stress protocol introduces a combined model of depression in rats: reversibility by imipramine and pentoxifylline.
    Pharmacology, biochemistry, and behavior, 2014, Volume: 126

    Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Corticosterone; Depression; Disease Mod

2014
Effects of N-acetylcysteine and imipramine in a model of acute rhythm disruption in BALB/c mice.
    Chronobiology international, 2015, Volume: 32, Issue:2

    Topics: Acetylcysteine; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Circadian Rhythm; Corti

2015
GABAB(1) receptor subunit isoforms differentially regulate stress resilience.
    Proceedings of the National Academy of Sciences of the United States of America, 2014, Oct-21, Volume: 111, Issue:42

    Topics: Anhedonia; Animals; Behavior, Animal; Cell Proliferation; Corticosterone; Depression; Disease Models

2014
Long-term corticosterone exposure decreases insulin sensitivity and induces depressive-like behaviour in the C57BL/6NCrl mouse.
    PloS one, 2014, Volume: 9, Issue:10

    Topics: Animals; Behavior, Animal; Blood Glucose; Corticosterone; Depression; Disease Models, Animal; Hypoth

2014
Folic acid prevents depressive-like behavior induced by chronic corticosterone treatment in mice.
    Pharmacology, biochemistry, and behavior, 2014, Volume: 127

    Topics: Animals; Antidepressive Agents; Corticosterone; Depression; Drug Administration Schedule; Female; Fo

2014
WY14643 produces anti-depressant-like effects in mice via the BDNF signaling pathway.
    Psychopharmacology, 2015, Volume: 232, Issue:9

    Topics: Animals; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Depressive Disorder; Hindlim

2015
Antidepressant-like effects of a novel 5-HT3 receptor antagonist 6z in acute and chronic murine models of depression.
    Acta pharmacologica Sinica, 2014, Volume: 35, Issue:12

    Topics: Acute Disease; Animals; Antidepressive Agents; Antioxidants; Behavior, Animal; Benzothiazoles; Bioma

2014
Early-life stress selectively affects gastrointestinal but not behavioral responses in a genetic model of brain-gut axis dysfunction.
    Neurogastroenterology and motility, 2015, Volume: 27, Issue:1

    Topics: Animals; Anxiety; Brain; Colon; Corticosterone; Depression; Disease Models, Animal; Female; Gastroin

2015
Insulin-like growth factor 2 mitigates depressive behavior in a rat model of chronic stress.
    Neuropharmacology, 2015, Volume: 89

    Topics: Animals; Body Weight; Chronic Disease; Corticosterone; Depression; Disease Models, Animal; Food Pref

2015
Honokiol abrogates lipopolysaccharide-induced depressive like behavior by impeding neuroinflammation and oxido-nitrosative stress in mice.
    European journal of pharmacology, 2014, Dec-05, Volume: 744

    Topics: Animals; Antidepressive Agents; Biphenyl Compounds; Brain-Derived Neurotrophic Factor; Corticosteron

2014
Social overcrowding as a chronic stress model that increases adiposity in mice.
    Psychoneuroendocrinology, 2015, Volume: 51

    Topics: Adiponectin; Adiposity; Animals; Anxiety; Behavior, Animal; Body Weight; Corticosterone; Crowding; D

2015
Chronic corticosterone exposure reduces hippocampal glycogen level and induces depression-like behavior in mice.
    Journal of Zhejiang University. Science. B, 2015, Volume: 16, Issue:1

    Topics: Animals; Astrocytes; Behavior, Animal; Brain; Corticosterone; Depression; Disease Models, Animal; Gl

2015
Chronic all-trans retinoic acid administration induces CRF over-expression accompanied by AVP up-regulation and multiple CRF-controlling receptors disturbance in the hypothalamus of rats.
    Brain research, 2015, Mar-19, Volume: 1601

    Topics: Animals; Arginine Vasopressin; Corticosterone; Corticotropin-Releasing Hormone; Depression; Disease

2015
GPR39 (zinc receptor) knockout mice exhibit depression-like behavior and CREB/BDNF down-regulation in the hippocampus.
    The international journal of neuropsychopharmacology, 2014, Oct-31, Volume: 18, Issue:3

    Topics: Animals; Brain-Derived Neurotrophic Factor; Corticosterone; CREB-Binding Protein; Dark Adaptation; D

2014
Effect of a novel 5-HT3 receptor antagonist 4i, in corticosterone-induced depression-like behavior and oxidative stress in mice.
    Steroids, 2015, Volume: 96

    Topics: Animals; Behavior, Animal; Catalase; Corticosterone; Depression; Glutathione; Hypothalamus; Lipid Pe

2015
Imipramine protects against the deleterious effects of chronic corticosterone on depression-like behavior, hippocampal reelin expression, and neuronal maturation.
    Progress in neuro-psychopharmacology & biological psychiatry, 2015, Jul-03, Volume: 60

    Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents, Tricyclic; Cell Adhesion Molecules, Neuron

2015
Hypothalamic-pituitary-adrenal axis and behavioral dysfunction following early binge-like prenatal alcohol exposure in mice.
    Alcohol (Fayetteville, N.Y.), 2015, Volume: 49, Issue:3

    Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Behavior, Animal; Binge Drinking; Central Nervous Sys

2015
Chronic corticosterone exposure reduces hippocampal astrocyte structural plasticity and induces hippocampal atrophy in mice.
    Neuroscience letters, 2015, Apr-10, Volume: 592

    Topics: Animals; Astrocytes; Atrophy; Corticosterone; Depression; Glial Fibrillary Acidic Protein; Hippocamp

2015
Effect of chronic corticosterone application on depression-like behavior in C57BL/6N and C57BL/6J mice.
    Genes, brain, and behavior, 2015, Volume: 14, Issue:3

    Topics: Animals; Behavior, Animal; Corticosterone; Depression; Male; Mice; Mice, Inbred C57BL

2015
Lack of stress responses to long-term effects of corticosterone in Caps2 knockout mice.
    Scientific reports, 2015, Mar-10, Volume: 5

    Topics: Animals; Anxiety; Behavior, Animal; Body Weight; Calcium-Binding Proteins; Corticosterone; Depressio

2015
Prenatal maternal immune activation increases anxiety- and depressive-like behaviors in offspring with experimental autoimmune encephalomyelitis.
    Neuroscience, 2015, May-21, Volume: 294

    Topics: Animals; Anxiety; Anxiety Disorders; Behavior, Animal; Corticosterone; Depression; Encephalomyelitis

2015
Increasing Adult Hippocampal Neurogenesis is Sufficient to Reduce Anxiety and Depression-Like Behaviors.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015, Volume: 40, Issue:10

    Topics: Animals; Anxiety; bcl-2-Associated X Protein; Bromodeoxyuridine; Corticosterone; Depression; Disease

2015
Subchronic administration of riparin III induces antidepressive-like effects and increases BDNF levels in the mouse hippocampus.
    Fundamental & clinical pharmacology, 2015, Volume: 29, Issue:4

    Topics: Anhedonia; Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Benzamides; Brain-Derived Neur

2015
Antidepressant-like effects of oleoylethanolamide in a mouse model of chronic unpredictable mild stress.
    Pharmacology, biochemistry, and behavior, 2015, Volume: 133

    Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Antioxidants; Atrophy; Brain-Derived Ne

2015
Long-term effects of early adolescent stress: dysregulation of hypothalamic-pituitary-adrenal axis and central corticotropin releasing factor receptor 1 expression in adult male rats.
    Behavioural brain research, 2015, Jul-15, Volume: 288

    Topics: Animals; Anxiety; Corticosterone; Depression; Disease Models, Animal; Electroshock; Exercise Therapy

2015
Neurogenesis-independent antidepressant-like effects of enriched environment is dependent on adiponectin.
    Psychoneuroendocrinology, 2015, Volume: 57

    Topics: Adiponectin; Animal Welfare; Animals; Anxiety; Behavior Rating Scale; Behavior, Animal; Corticostero

2015
Mice age - Does the age of the mother predict offspring behaviour?
    Physiology & behavior, 2015, Aug-01, Volume: 147

    Topics: Adaptation, Ocular; Age Factors; Aging; Animals; Anxiety; Corticosterone; Depression; Disease Models

2015
Nrf2-signaling and BDNF: A new target for the antidepressant-like activity of chronic fluoxetine treatment in a mouse model of anxiety/depression.
    Neuroscience letters, 2015, Jun-15, Volume: 597

    Topics: Animals; Antidepressive Agents; Anxiety; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Cortico

2015
LC-MS/MS based studies on the anti-depressant effect of hypericin in the chronic unpredictable mild stress rat model.
    Journal of ethnopharmacology, 2015, Jul-01, Volume: 169

    Topics: Amino Acids; Animals; Anthracenes; Antidepressive Agents; Behavior, Animal; Chromatography, Liquid;

2015
Agmatine, by Improving Neuroplasticity Markers and Inducing Nrf2, Prevents Corticosterone-Induced Depressive-Like Behavior in Mice.
    Molecular neurobiology, 2016, Volume: 53, Issue:5

    Topics: Agmatine; Anhedonia; Animals; Antidepressive Agents; Astrocytes; Behavior, Animal; Biomarkers; Corti

2016
Activation of GABA-A receptors during postnatal brain development increases anxiety- and depression-related behaviors in a time- and dose-dependent manner in adult mice.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2015, Volume: 25, Issue:8

    Topics: Animals; Animals, Newborn; Anxiety; Bicuculline; Brain; Corticosterone; Depression; Dose-Response Re

2015
m-Trifluoromethyl-diphenyl diselenide, a multi-target selenium compound, prevented mechanical allodynia and depressive-like behavior in a mouse comorbid pain and depression model.
    Progress in neuro-psychopharmacology & biological psychiatry, 2015, Dec-03, Volume: 63

    Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Brain; Corticosterone; Cytokines; Depre

2015
Ketamine as a Prophylactic Against Stress-Induced Depressive-like Behavior.
    Biological psychiatry, 2016, May-01, Volume: 79, Issue:9

    Topics: Animals; Antidepressive Agents; Anxiety; Corticosterone; Depression; Fear; Helplessness, Learned; Ke

2016
Resveratrol ameliorates depressive-like behavior in repeated corticosterone-induced depression in mice.
    Steroids, 2015, Volume: 101

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone;

2015
Venlafaxine reverses decreased proliferation in the subventricular zone in a rat model of early life stress.
    Behavioural brain research, 2015, Oct-01, Volume: 292

    Topics: Animals; Behavior, Animal; Cell Proliferation; Cognition Disorders; Corticosterone; Depression; Late

2015
Effects of nitric oxide synthesis inhibitor or fluoxetine treatment on depression-like state and cardiovascular changes induced by chronic variable stress in rats.
    Stress (Amsterdam, Netherlands), 2015, Volume: 18, Issue:4

    Topics: Animals; Antidepressive Agents; Autonomic Nervous System; Baroreflex; Behavior, Animal; Cardiovascul

2015
Mice heterozygous for cathepsin D deficiency exhibit mania-related behavior and stress-induced depression.
    Progress in neuro-psychopharmacology & biological psychiatry, 2015, Dec-03, Volume: 63

    Topics: Adaptation, Ocular; Animals; Antidepressive Agents; Bipolar Disorder; Cathepsin D; Corticosterone; D

2015
Therapeutic antidepressant potential of a conjugated siRNA silencing the serotonin transporter after intranasal administration.
    Molecular psychiatry, 2016, Volume: 21, Issue:3

    Topics: Administration, Intranasal; Animals; Antidepressive Agents; Arabidopsis Proteins; Brain; Corticoster

2016
Antidepressant-like effect of simvastatin in diabetic rats.
    Canadian journal of physiology and pharmacology, 2015, Volume: 93, Issue:8

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Clomipramine; Corticosterone; Depression; Diabetes

2015
Angelica gigas ameliorate depression-like symptoms in rats following chronic corticosterone injection.
    BMC complementary and alternative medicine, 2015, Jul-03, Volume: 15

    Topics: Angelica; Animals; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Male; Plant

2015
Phosphodiesterase-4D Knock-down in the Prefrontal Cortex Alleviates Chronic Unpredictable Stress-Induced Depressive-Like Behaviors and Memory Deficits in Mice.
    Scientific reports, 2015, Jul-10, Volume: 5

    Topics: Animals; Body Weight; Corticosterone; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cycli

2015
Alterations in circadian entrainment precede the onset of depression-like behavior that does not respond to fluoxetine.
    Translational psychiatry, 2015, Jul-14, Volume: 5

    Topics: Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Circadian Rhythm; Corticosteron

2015
Circadian variations in behaviors, BDNF and cell proliferation in depressive mice.
    Metabolic brain disease, 2015, Volume: 30, Issue:6

    Topics: Anhedonia; Animals; Behavior, Animal; Body Weight; Brain-Derived Neurotrophic Factor; Cell Prolifera

2015
Ondansetron attenuates co-morbid depression and anxiety associated with obesity by inhibiting the biochemical alterations and improving serotonergic neurotransmission.
    Pharmacology, biochemistry, and behavior, 2015, Volume: 136

    Topics: Animals; Anxiety; Behavior, Animal; Body Weight; Brain; Citalopram; Corticosterone; Depression; Diet

2015
Enriched environment decreases microglia and brain macrophages inflammatory phenotypes through adiponectin-dependent mechanisms: Relevance to depressive-like behavior.
    Brain, behavior, and immunity, 2015, Volume: 50

    Topics: Adiponectin; Animals; Corticosterone; Cytokines; Depression; Encephalitis; Environment; Hippocampus;

2015
Antidepressant-like effects of quercetin in diabetic rats are independent of hypothalamic-pituitary-adrenal axis.
    Acta neuropsychiatrica, 2016, Volume: 28, Issue:1

    Topics: Adrenocorticotropic Hormone; Animals; Antibiotics, Antineoplastic; Antidepressive Agents; Antioxidan

2016
MeCP2 controls hippocampal brain-derived neurotrophic factor expression via homeostatic interactions with microRNA‑132 in rats with depression.
    Molecular medicine reports, 2015, Volume: 12, Issue:4

    Topics: Animals; Brain-Derived Neurotrophic Factor; Case-Control Studies; Corticosterone; Depression; Depres

2015
Calcitonin gene-related peptide pre-administration acts as a novel antidepressant in stressed mice.
    Scientific reports, 2015, Aug-07, Volume: 5

    Topics: Animals; Antidepressive Agents; Calcitonin Gene-Related Peptide; Cell Line; Corticosterone; Depressi

2015
Mice undergoing neuropathic pain induce anxiogenic-like effects and hypernociception in cagemates.
    Behavioural pharmacology, 2015, Volume: 26, Issue:7 Spec No

    Topics: Animals; Anxiety; Corticosterone; Depression; Dietary Sucrose; Male; Mice; Neuralgia; Nociceptive Pa

2015
Antidepressant-Like Effects of Sanggenon G, Isolated from the Root Bark of Morus alba, in Rats: Involvement of the Serotonergic System.
    Biological & pharmaceutical bulletin, 2015, Volume: 38, Issue:11

    Topics: Animals; Antidepressive Agents; Benzofurans; Chromones; Corticosterone; Depression; Hypothalamo-Hypo

2015
ATP-sensitive potassium channels: uncovering novel targets for treating depression.
    Brain structure & function, 2016, Volume: 221, Issue:6

    Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Count; Cell Survival; Corticosterone; Depression; H

2016
Acute, but not chronic, stress increased the plasma concentration and hypothalamic mRNA expression of NUCB2/nesfatin-1 in rats.
    Neuropeptides, 2015, Volume: 54

    Topics: Animals; Calcium-Binding Proteins; Corticosterone; Depression; DNA-Binding Proteins; Hypothalamus; M

2015
TrkB in the hippocampus and nucleus accumbens differentially modulates depression-like behavior in mice.
    Behavioural brain research, 2016, Jan-01, Volume: 296

    Topics: Animals; Anxiety; Astrocytes; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal;

2016
Prenatal stress programs neuroendocrine stress responses and affective behaviors in second generation rats in a sex-dependent manner.
    Psychoneuroendocrinology, 2015, Volume: 62

    Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Behavior, Animal; Corticosterone; Corticotropin-Relea

2015
Beneficial Effects of Highly Palatable Food on the Behavioral and Neural Adversities induced by Early Life Stress Experience in Female Rats.
    International journal of biological sciences, 2015, Volume: 11, Issue:10

    Topics: Animals; Anxiety; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; F

2015
Behavioural and neurobiological consequences of macrophage migration inhibitory factor gene deletion in mice.
    Journal of neuroinflammation, 2015, Sep-04, Volume: 12

    Topics: Animals; Biogenic Monoamines; Corticosterone; Cytokines; Depression; Disease Models, Animal; Explora

2015
Reversal of corticosterone-induced BDNF alterations by the natural antioxidant alpha-lipoic acid alone and combined with desvenlafaxine: Emphasis on the neurotrophic hypothesis of depression.
    Psychiatry research, 2015, Dec-15, Volume: 230, Issue:2

    Topics: Animals; Antidepressive Agents; Antioxidants; Brain-Derived Neurotrophic Factor; Corticosterone; Dep

2015
Depressive-like phenotype induced by AAV-mediated overexpression of human α-synuclein in midbrain dopaminergic neurons.
    Experimental neurology, 2015, Volume: 273

    Topics: Adrenocorticotropic Hormone; alpha-Synuclein; Animals; Corticosterone; Dependovirus; Depression; Dis

2015
Antidepressant-like activity of plumbagin in unstressed and stressed mice.
    Pharmacological reports : PR, 2015, Volume: 67, Issue:5

    Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Antioxidants; Behavior, Animal; Br

2015
Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress.
    Neuroscience, 2015, Dec-03, Volume: 310

    Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Behavior, Animal; Body Weight; Brain-Derived Neurotro

2015
H2S protects PC12 cells against toxicity of corticosterone by modulation of BDNF-TrkB pathway.
    Acta biochimica et biophysica Sinica, 2015, Volume: 47, Issue:11

    Topics: Animals; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Hydrogen Sulfide; Membrane G

2015
Despair-associated memory requires a slow-onset CA1 long-term potentiation with unique underlying mechanisms.
    Scientific reports, 2015, Oct-09, Volume: 5

    Topics: Animals; CA1 Region, Hippocampal; Corticosterone; Depression; Dizocilpine Maleate; Excitatory Amino

2015
Neonatal tactile stimulation decreases depression-like and anxiety-like behaviors and potentiates sertraline action in young rats.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2015, Volume: 47, Issue:Pt B

    Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Anxiety; Corticosterone; Depression; D

2015
Tris-(2,3-Dibromopropyl) Isocyanurate, a New Emerging Pollutant, Impairs Cognition and Provokes Depression-Like Behaviors in Adult Rats.
    PloS one, 2015, Volume: 10, Issue:10

    Topics: Adrenocorticotropic Hormone; Animals; Behavior, Animal; Biomarkers; Brain-Derived Neurotrophic Facto

2015
Enzymatic Depletion of the Polysialic Acid Moiety Associated with the Neural Cell Adhesion Molecule Inhibits Antidepressant Efficacy.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016, Volume: 41, Issue:6

    Topics: Animals; Antidepressive Agents, Second-Generation; Corticosterone; Depression; Disease Models, Anima

2016
Sex-related effects of sleep deprivation on depressive- and anxiety-like behaviors in mice.
    Experimental animals, 2016, Volume: 65, Issue:1

    Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Eating; Female; Locomotion; Male; Mi

2016
Effectiveness of different corticosterone administration methods to elevate corticosterone serum levels, induce depressive-like behavior, and affect neurogenesis levels in female rats.
    Neuroscience, 2016, Jan-15, Volume: 312

    Topics: Animals; Behavior, Animal; Body Weight; Corticosterone; Dentate Gyrus; Depression; Disease Models, A

2016
SLC6A15, a novel stress vulnerability candidate, modulates anxiety and depressive-like behavior: involvement of the glutamatergic system.
    Stress (Amsterdam, Netherlands), 2016, Volume: 19, Issue:1

    Topics: Alleles; Amino Acid Transport Systems, Neutral; Animals; Anxiety; Behavior, Animal; Corticosterone;

2016
Antidepressant-like effect of the water extract of the fixed combination of Gardenia jasminoides, Citrus aurantium and Magnolia officinalis in a rat model of chronic unpredictable mild stress.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2015, Dec-01, Volume: 22, Issue:13

    Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Citr

2015
Lipopolysaccharide induced anxiety- and depressive-like behaviour in mice are prevented by chronic pre-treatment of esculetin.
    Neuroscience letters, 2016, Jan-12, Volume: 611

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Anxiety; Behavior, Animal; Corticosterone; Depressi

2016
Myricetin Attenuates Depressant-Like Behavior in Mice Subjected to Repeated Restraint Stress.
    International journal of molecular sciences, 2015, Nov-30, Volume: 16, Issue:12

    Topics: Animals; Antidepressive Agents; Antioxidants; Behavior, Animal; Brain-Derived Neurotrophic Factor; C

2015
Creatine, Similar to Ketamine, Counteracts Depressive-Like Behavior Induced by Corticosterone via PI3K/Akt/mTOR Pathway.
    Molecular neurobiology, 2016, Volume: 53, Issue:10

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone;

2016
In-depth behavioral characterization of the corticosterone mouse model and the critical involvement of housing conditions.
    Physiology & behavior, 2016, Mar-15, Volume: 156

    Topics: Animals; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Exploratory Behavior;

2016
Effects of Escitalopram on a Rat Model of Persistent Stress-Altered Hedonic Activities: Towards a New Understanding of Stress and Depression.
    The Chinese journal of physiology, 2015, Dec-31, Volume: 58, Issue:6

    Topics: Age Factors; Animals; Antidepressive Agents, Second-Generation; Citalopram; Corticosterone; Depressi

2015
Tempol protects sleep-deprivation induced behavioral deficits in aggressive male Long-Evans rats.
    Neuroscience letters, 2016, Jan-26, Volume: 612

    Topics: Aggression; Aging; Animals; Antioxidants; Anxiety; Behavior, Animal; Corticosterone; Cyclic N-Oxides

2016
Rhythmical Photic Stimulation at Alpha Frequencies Produces Antidepressant-Like Effects in a Mouse Model of Depression.
    PloS one, 2016, Volume: 11, Issue:1

    Topics: Animals; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Fluoxetine; Male; Mic

2016
Anxiety- and Depression-Like States Lead to Pronounced Olfactory Deficits and Impaired Adult Neurogenesis in Mice.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, Jan-13, Volume: 36, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents, Second-Generation; Anxiety; Cell Prolifera

2016
Berberine up-regulates the BDNF expression in hippocampus and attenuates corticosterone-induced depressive-like behavior in mice.
    Neuroscience letters, 2016, Feb-12, Volume: 614

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Berberine; Brain-Derived Neurotrophic Factor; Cort

2016
Electroacupuncture regulate hypothalamic-pituitary-adrenal axis and enhance hippocampal serotonin system in a rat model of depression.
    Neuroscience letters, 2016, Feb-26, Volume: 615

    Topics: Adrenocorticotropic Hormone; Animals; Corticosterone; Corticotropin-Releasing Hormone; Depression; E

2016
Testosterone has antidepressant-like efficacy and facilitates imipramine-induced neuroplasticity in male rats exposed to chronic unpredictable stress.
    Hormones and behavior, 2016, Volume: 79

    Topics: Animals; Antidepressive Agents; Chronic Disease; Corticosterone; Dentate Gyrus; Depression; Disease

2016
Opposite Sex Contact and Isolation: A Novel Depression/Anxiety Model.
    Neuroscience bulletin, 2016, Volume: 32, Issue:1

    Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Cyclic AMP Response Element-Binding Protein; Dep

2016
Effect of Inhaling Bergamot Oil on Depression-Related Behaviors in Chronic Stressed Rats.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2015, Volume: 98 Suppl 9

    Topics: Animals; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Depressive Disorder; Hippoca

2015
Apigenin reverses depression-like behavior induced by chronic corticosterone treatment in mice.
    European journal of pharmacology, 2016, Mar-05, Volume: 774

    Topics: Animals; Antidepressive Agents; Apigenin; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corti

2016
Chronic 5-HT4 receptor agonist treatment restores learning and memory deficits in a neuroendocrine mouse model of anxiety/depression.
    Neuroscience letters, 2016, Mar-11, Volume: 616

    Topics: Aniline Compounds; Animals; Antidepressive Agents; Anxiety; Association Learning; Corticosterone; De

2016
Neonatal proinflammatory challenge in male Wistar rats: Effects on behavior, synaptic plasticity, and adrenocortical stress response.
    Behavioural brain research, 2016, May-01, Volume: 304

    Topics: Age Factors; Animals; Animals, Newborn; Anxiety; Conditioning, Psychological; Corticosterone; Depres

2016
Apelin-13 exerts antidepressant-like and recognition memory improving activities in stressed rats.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2016, Volume: 26, Issue:3

    Topics: Animals; Antidepressive Agents; Chromones; Corticosterone; Depression; Disease Models, Animal; Enzym

2016
Icariin reverses corticosterone-induced depression-like behavior, decrease in hippocampal brain-derived neurotrophic factor (BDNF) and metabolic network disturbances revealed by NMR-based metabonomics in rats.
    Journal of pharmaceutical and biomedical analysis, 2016, May-10, Volume: 123

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone;

2016
Social Isolation Stress Induces Anxious-Depressive-Like Behavior and Alterations of Neuroplasticity-Related Genes in Adult Male Mice.
    Neural plasticity, 2016, Volume: 2016

    Topics: Adrenal Glands; Animals; Anxiety; Brain-Derived Neurotrophic Factor; Corticosterone; Cytoskeletal Pr

2016
Zinc and imipramine reverse the depression-like behavior in mice induced by chronic restraint stress.
    Journal of affective disorders, 2016, Volume: 197

    Topics: Animals; Brain-Derived Neurotrophic Factor; Corticosterone; CREB-Binding Protein; Depression; Depres

2016
Antidepressant-Like Effect of Ropren® in β-Amyloid-(25-35) Rat Model of Alzheimer's Disease with Altered Levels of Androgens.
    Molecular neurobiology, 2017, Volume: 54, Issue:4

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Androgens; Animals; Antidepressive Agents; Corticosterone;

2017
The role of medial prefrontal corticosterone and dopamine in the antidepressant-like effect of exercise.
    Psychoneuroendocrinology, 2016, Volume: 69

    Topics: Animals; Antidepressive Agents; Corticosterone; Depression; Depressive Disorder; Dopamine; Glucocort

2016
Neonatal handling alters maternal emotional response to stress.
    Developmental psychobiology, 2016, Volume: 58, Issue:5

    Topics: Adrenal Glands; Animals; Animals, Newborn; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cort

2016
Disturbed diurnal rhythm of three classical phase markers in the chronic mild stress rat model of depression.
    Neuroscience research, 2016, Volume: 110

    Topics: Anhedonia; Animals; Biomarkers; Body Temperature; Circadian Rhythm; Corticosterone; Depression; Eati

2016
Chronic intermittent ethanol exposure during adolescence: Effects on stress-induced social alterations and social drinking in adulthood.
    Brain research, 2017, 01-01, Volume: 1654, Issue:Pt B

    Topics: Aging; Alcohol Drinking; Animals; Anxiety; Binge Drinking; Central Nervous System Depressants; Corti

2017
Antidepressant-like Effects of LPM580153, A Novel Potent Triple Reuptake Inhibitor.
    Scientific reports, 2016, Apr-07, Volume: 6

    Topics: Anhedonia; Animals; Antidepressive Agents; Biological Transport; Blotting, Western; Brain-Derived Ne

2016
Antidepressant-like effects of water extract of Gastrodia elata Blume in rats exposed to unpredictable chronic mild stress via modulation of monoamine regulatory pathways.
    Journal of ethnopharmacology, 2016, Jul-01, Volume: 187

    Topics: Animals; Antidepressive Agents; Benzyl Alcohols; Brain; Corticosterone; Depression; Dopamine; Gastro

2016
3,5,6,7,8,3',4'-Heptamethoxyflavone, a Citrus Flavonoid, Ameliorates Corticosterone-Induced Depression-like Behavior and Restores Brain-Derived Neurotrophic Factor Expression, Neurogenesis, and Neuroplasticity in the Hippocampus.
    Molecules (Basel, Switzerland), 2016, Apr-23, Volume: 21, Issue:4

    Topics: Animals; Behavior, Animal; Body Weight; Brain-Derived Neurotrophic Factor; Citrus; Corticosterone; D

2016
Fourteen-day administration of corticosterone may induce detrusor overactivity symptoms.
    International urogynecology journal, 2016, Volume: 27, Issue:11

    Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Corticosterone; Depression; Disease

2016
Loss of dopaminergic neurons occurs in the ventral tegmental area and hypothalamus of rats following chronic stress: Possible pathogenetic loci for depression involved in Parkinson's disease.
    Neuroscience research, 2016, Volume: 111

    Topics: Animals; Corticosterone; Depression; Dopaminergic Neurons; Hypothalamus; Male; Microglia; Nerve Dege

2016
Adjuvant indoleamine 2,3-dioxygenase enzyme inhibition for comprehensive management of epilepsy and comorbid depression.
    European journal of pharmacology, 2016, Aug-05, Volume: 784

    Topics: Animals; Comorbidity; Corticosterone; Depression; Drug Interactions; Enzyme Inhibitors; Epilepsy; Hi

2016
Disruption of the HPA-axis through corticosterone-release pellets induces robust depressive-like behavior and reduced BDNF levels in mice.
    Neuroscience letters, 2016, 07-28, Volume: 626

    Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Dopamine;

2016
Naringin and Sertraline Ameliorate Doxorubicin-Induced Behavioral Deficits Through Modulation of Serotonin Level and Mitochondrial Complexes Protection Pathway in Rat Hippocampus.
    Neurochemical research, 2016, Volume: 41, Issue:9

    Topics: Animals; Behavior, Animal; Corticosterone; Depression; Doxorubicin; Flavanones; Hippocampus; Male; M

2016
Antidepressant imipramine diminishes stress-induced inflammation in the periphery and central nervous system and related anxiety- and depressive- like behaviors.
    Brain, behavior, and immunity, 2016, Volume: 57

    Topics: Animals; Antidepressive Agents, Tricyclic; Anxiety; Behavior, Animal; Corticosterone; Depression; Im

2016
Hypothalamic Proteomic Analysis Reveals Dysregulation of Glutamate Balance and Energy Metabolism in a Mouse Model of Chronic Mild Stress-Induced Depression.
    Neurochemical research, 2016, Volume: 41, Issue:9

    Topics: Animals; Corticosterone; Depression; Depressive Disorder; Disease Models, Animal; Energy Metabolism;

2016
Chronic activation of NPFFR2 stimulates the stress-related depressive behaviors through HPA axis modulation.
    Psychoneuroendocrinology, 2016, Volume: 71

    Topics: Animals; Antidepressive Agents; Anxiety; Anxiety Disorders; Chronic Disease; Corticosterone; Cortico

2016
Adipogenesis and aldosterone: a study in lean tryptophan-depleted rats.
    General physiology and biophysics, 2016, Volume: 35, Issue:3

    Topics: Adipogenesis; Aldosterone; Animals; Corticosterone; Depression; Female; Rats; Rats, Sprague-Dawley;

2016
Simultaneous Changes in Sleep, qEEG, Physiology, Behaviour and Neurochemistry in Rats Exposed to Repeated Social Defeat Stress.
    Neuropsychobiology, 2016, Volume: 73, Issue:4

    Topics: Animals; Behavior, Animal; Brain; Corticosterone; Depression; Disease Models, Animal; Dopamine; Elec

2016
Elevated paternal glucocorticoid exposure alters the small noncoding RNA profile in sperm and modifies anxiety and depressive phenotypes in the offspring.
    Translational psychiatry, 2016, 06-14, Volume: 6, Issue:6

    Topics: Animals; Anxiety; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Exons; Fear; Female

2016
Mgat5 modulates the effect of early life stress on adult behavior and physical health in mice.
    Behavioural brain research, 2016, 10-01, Volume: 312

    Topics: Animals; Body Weight; Bone Density; Brain; Corticosterone; Dendritic Spines; Depression; Female; Gen

2016
Effects of environmental stress on the depression-like behaviors and the diurnal rhythm of corticosterone and melatonin in male rats.
    Sheng li xue bao : [Acta physiologica Sinica], 2016, Jun-25, Volume: 68, Issue:3

    Topics: Animals; Anxiety; Behavior, Animal; Circadian Rhythm; Corticosterone; Depression; Depressive Disorde

2016
Depression-Like Adult Behaviors may be a Long-Term Result of Experimental Pneumococcal Meningitis in Wistar Rats Infants.
    Neurochemical research, 2016, Volume: 41, Issue:10

    Topics: Animals; Behavior, Animal; Brain; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Dis

2016
Schisandra chinensis produces the antidepressant-like effects in repeated corticosterone-induced mice via the BDNF/TrkB/CREB signaling pathway.
    Psychiatry research, 2016, Sep-30, Volume: 243

    Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Corticosterone; Cyclic AMP Respon

2016
Male-specific effects of lipopolysaccharide on glucocorticoid receptor nuclear translocation in the prefrontal cortex of depressive rats.
    Psychopharmacology, 2016, Volume: 233, Issue:18

    Topics: Animals; Behavior, Animal; Cell Nucleus; Corticosterone; Depression; Depressive Disorder, Major; Fem

2016
Antidepressant treatment differentially affects the phenotype of high and low stress reactive mice.
    Neuropharmacology, 2016, Volume: 110, Issue:Pt A

    Topics: Adaptation, Psychological; Animals; Antidepressive Agents; Corticosterone; Depression; Fluoxetine; H

2016
Chinese herbal medicines promote hippocampal neuroproliferation, reduce stress hormone levels, inhibit apoptosis, and improve behavior in chronically stressed mice.
    Journal of ethnopharmacology, 2016, Dec-04, Volume: 193

    Topics: Animals; Apoptosis; Behavior, Animal; Cell Line; Cell Proliferation; Corticosterone; Depression; Dru

2016
Repeated treatment with oxytocin promotes hippocampal cell proliferation, dendritic maturation and affects socio-emotional behavior.
    Neuroscience, 2016, 10-01, Volume: 333

    Topics: Animals; Anxiety; Cell Proliferation; Corticosterone; Dendrites; Dentate Gyrus; Depression; Disease

2016
Omega-3 polyunsaturated fatty acids critically regulate behaviour and gut microbiota development in adolescence and adulthood.
    Brain, behavior, and immunity, 2017, Volume: 59

    Topics: Aging; Animals; Behavior, Animal; Cognition; Corticosterone; Cytokines; Depression; Fatty Acids; Fat

2017
Evaluation of the antidepressant-like effect of musk in an animal model of depression: how it works.
    Anatomical science international, 2017, Volume: 92, Issue:4

    Topics: Administration, Inhalation; Animals; Antidepressive Agents; Behavior; Brain-Derived Neurotrophic Fac

2017
miR-17-92 Cluster Regulates Adult Hippocampal Neurogenesis, Anxiety, and Depression.
    Cell reports, 2016, 08-09, Volume: 16, Issue:6

    Topics: Aging; Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Hippo

2016
The antidepressant effect of musk in an animal model of depression: a histopathological study.
    Cell and tissue research, 2016, Volume: 366, Issue:2

    Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Caspase 3; Corticosterone; Depres

2016
Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat.
    Journal of psychiatric research, 2016, Volume: 82

    Topics: Adult; Aged; Animals; C-Reactive Protein; Case-Control Studies; Corticosterone; Cytokines; Depressio

2016
Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat.
    Journal of psychiatric research, 2016, Volume: 82

    Topics: Adult; Aged; Animals; C-Reactive Protein; Case-Control Studies; Corticosterone; Cytokines; Depressio

2016
Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat.
    Journal of psychiatric research, 2016, Volume: 82

    Topics: Adult; Aged; Animals; C-Reactive Protein; Case-Control Studies; Corticosterone; Cytokines; Depressio

2016
Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat.
    Journal of psychiatric research, 2016, Volume: 82

    Topics: Adult; Aged; Animals; C-Reactive Protein; Case-Control Studies; Corticosterone; Cytokines; Depressio

2016
Baicalin promotes hippocampal neurogenesis via SGK1- and FKBP5-mediated glucocorticoid receptor phosphorylation in a neuroendocrine mouse model of anxiety/depression.
    Scientific reports, 2016, 08-09, Volume: 6

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Anxiety; Behavior, Anima

2016
Neuroprotective, Neurotrophic and Anti-oxidative Role of Bacopa monnieri on CUS Induced Model of Depression in Rat.
    Neurochemical research, 2016, Volume: 41, Issue:11

    Topics: Animals; Antidepressive Agents; Antioxidants; Bacopa; Behavior, Animal; Corticosterone; Depression;

2016
Bilobalide alleviates depression-like behavior and cognitive deficit induced by chronic unpredictable mild stress in mice.
    Behavioural pharmacology, 2016, Volume: 27, Issue:7

    Topics: Animals; Behavior, Animal; Cognition Disorders; Corticosterone; Cyclopentanes; Depression; Discrimin

2016
Short- and long-term effects of stress during adolescence on emotionality and HPA function of animals exposed to alcohol prenatally.
    Psychoneuroendocrinology, 2016, Volume: 74

    Topics: Age Factors; Animals; Anxiety; Basolateral Nuclear Complex; Behavior, Animal; Central Nervous System

2016
Postnatal light alters hypothalamic-pituitary-adrenal axis function and induces a depressive-like phenotype in adult mice.
    The European journal of neuroscience, 2016, Volume: 44, Issue:10

    Topics: Animals; Body Temperature; Circadian Rhythm; Corticosterone; Corticotropin-Releasing Hormone; Depres

2016
Traditional herbal formula Sini Powder extract produces antidepressant-like effects through stress-related mechanisms in rats.
    Chinese journal of natural medicines, 2016, Volume: 14, Issue:8

    Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Corticosterone; Depression; Drugs, Chin

2016
Early Life Stress Increases Metabolic Risk, HPA Axis Reactivity, and Depressive-Like Behavior When Combined with Postweaning Social Isolation in Rats.
    PloS one, 2016, Volume: 11, Issue:9

    Topics: Adaptation, Psychological; Animals; Behavior, Animal; Corticosterone; Depression; Female; Glucose; H

2016
Antidepressant-like effects and cognitive enhancement of the total phenols extract of Hemerocallis citrina Baroni in chronic unpredictable mild stress rats and its related mechanism.
    Journal of ethnopharmacology, 2016, Dec-24, Volume: 194

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Biogenic Monoamines; Brain-Derived Neurotrophic Fa

2016
Chronic corticosterone treatment enhances extinction-induced depression in aged rats.
    Hormones and behavior, 2016, Volume: 86

    Topics: Aging; Animals; Corticosterone; Cues; Depression; Extinction, Psychological; Humans; Hypothalamo-Hyp

2016
Cipadesin A, a bioactive ingredient of Xylocarpus granatum, produces antidepressant-like effects in adult mice.
    Neuroscience letters, 2016, 10-28, Volume: 633

    Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Corticosterone; Depression; Hindlimb Su

2016
Selective CRF2 receptor agonists ameliorate the anxiety- and depression-like state developed during chronic nicotine treatment and consequent acute withdrawal in mice.
    Brain research, 2016, 12-01, Volume: 1652

    Topics: Animals; Anxiety; Corticosterone; Depression; Disease Models, Animal; Drug Evaluation, Preclinical;

2016
Neuropsin Inactivation Has Protective Effects against Depressive-Like Behaviours and Memory Impairment Induced by Chronic Stress.
    PLoS genetics, 2016, Volume: 12, Issue:10

    Topics: Animals; Corticosterone; Depression; Disease Models, Animal; Glutamic Acid; Hippocampus; Humans; Kal

2016
Perinatal programming of depressive-like behavior by inflammation in adult offspring mice whose mothers were fed polluted eels: Gender selective effects.
    Brain, behavior, and immunity, 2017, Volume: 63

    Topics: Animals; Behavior, Animal; Biomarkers; Brain; Corticosterone; Depression; Depressive Disorder; Femal

2017
Creatine Prevents Corticosterone-Induced Reduction in Hippocampal Proliferation and Differentiation: Possible Implication for Its Antidepressant Effect.
    Molecular neurobiology, 2017, Volume: 54, Issue:8

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Cell Differentiation; Cell Proliferation; Corticos

2017
Corticosteroids Mediate Heart Failure-Induced Depression through Reduced σ1-Receptor Expression.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Adenosine Triphosphate; Administration, Oral; Animals; Aorta; Behavior, Animal; Cardiomegaly; Cortic

2016
Behavioural and neurochemical consequences of chronic gut microbiota depletion during adulthood in the rat.
    Neuroscience, 2016, 12-17, Volume: 339

    Topics: Animals; Anti-Bacterial Agents; Anxiety; Brain; Brain-Derived Neurotrophic Factor; Cecum; Corticoste

2016
Resveratrol Ameliorates the Depressive-Like Behaviors and Metabolic Abnormalities Induced by Chronic Corticosterone Injection.
    Molecules (Basel, Switzerland), 2016, Oct-13, Volume: 21, Issue:10

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Blood Glucose; Body Weight; Corticosterone; Depres

2016
Attenuation of acute restraint stress-induced depressive like behavior and hippocampal alterations with protocatechuic acid treatment in mice.
    Metabolic brain disease, 2017, Volume: 32, Issue:2

    Topics: Animals; Antioxidants; Anxiety; Atrophy; Corticosterone; Depression; Female; Hippocampus; Hydroxyben

2017
Strain and sex based characterization of behavioral expressions in non-induced compulsive-like mice.
    Physiology & behavior, 2017, 01-01, Volume: 168

    Topics: Analysis of Variance; Animals; Corticosterone; Depression; Disease Models, Animal; Enzyme-Linked Imm

2017
M30 Antagonizes Indoleamine 2,3-Dioxygenase Activation and Neurodegeneration Induced by Corticosterone in the Hippocampus.
    PloS one, 2016, Volume: 11, Issue:11

    Topics: Animals; Corticosterone; Dendritic Spines; Depression; Enzyme Activation; Hippocampus; Hydroxyquinol

2016
Molecular modifications by regulating cAMP signaling and oxidant-antioxidant defence mechanisms, produce antidepressant-like effect: A possible mechanism of etazolate aftermaths of impact accelerated traumatic brain injury in rat model.
    Neurochemistry international, 2017, Volume: 111

    Topics: Animals; Antidepressive Agents; Antioxidants; Behavior, Animal; Brain Injuries, Traumatic; Corticost

2017
Antidepressant effect of recombinant NT4-NAP/AAV on social isolated mice through intranasal route.
    Oncotarget, 2017, Feb-07, Volume: 8, Issue:6

    Topics: Administration, Intranasal; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticoste

2017
Blunted 5-HT
    Psychopharmacology, 2017, Volume: 234, Issue:9-10

    Topics: Animals; Antidepressive Agents; Body Temperature; Brain; Corticosterone; Depression; Female; GABA An

2017
Alterations in splenic function and gene expression in mice with depressive-like behavior induced by exposure to corticosterone.
    International journal of molecular medicine, 2017, Volume: 39, Issue:2

    Topics: Animals; Behavior, Animal; Biomarkers; Cluster Analysis; Corticosterone; Depression; Disease Models,

2017
A mixed glucocorticoid/mineralocorticoid receptor modulator dampens endocrine and hippocampal stress responsivity in male rats.
    Physiology & behavior, 2017, Sep-01, Volume: 178

    Topics: Amygdala; Animals; Corticosterone; Depression; Hippocampus; Hormones; Imipramine; Male; Motor Activi

2017
Anhedonia but not passive floating is an indicator of depressive-like behavior in two chronic stress paradigms.
    Acta neurobiologiae experimentalis, 2016, Volume: 76, Issue:4

    Topics: Animals; Brain; Corticosterone; Depression; Disease Models, Animal; Electroshock; Exploratory Behavi

2016
Paternal environmental enrichment transgenerationally alters affective behavioral and neuroendocrine phenotypes.
    Psychoneuroendocrinology, 2017, Volume: 77

    Topics: Adrenocorticotropic Hormone; Animals; Behavior, Animal; Corticosterone; Depression; Environment; Epi

2017
Neonatal blockade of GABA-A receptors alters behavioral and physiological phenotypes in adult mice.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2017, Volume: 57

    Topics: Adaptation, Ocular; Age Factors; Animals; Animals, Newborn; Anxiety; Behavior, Animal; Bicuculline;

2017
Dissecting stress with transcriptomics.
    Oncotarget, 2017, Feb-14, Volume: 8, Issue:7

    Topics: Anxiety; Corticosterone; Corticotropin-Releasing Hormone; Depression; Drug Design; Female; Gene Expr

2017
Physical versus psychological social stress in male rats reveals distinct cardiovascular, inflammatory and behavioral consequences.
    PloS one, 2017, Volume: 12, Issue:2

    Topics: Anhedonia; Animals; Behavior, Animal; Blood Pressure; Cardiovascular Diseases; Chromatography, High

2017
Targeting the Microbiota-Gut-Brain Axis: Prebiotics Have Anxiolytic and Antidepressant-like Effects and Reverse the Impact of Chronic Stress in Mice.
    Biological psychiatry, 2017, Oct-01, Volume: 82, Issue:7

    Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Brain; Corticosterone; Depression; Dis

2017
Chronic unpredictable mild stress paradigm in male Wistar rats: effect on anxiety- and depressive-like behavior.
    Neuro endocrinology letters, 2016, Dec-18, Volume: 37, Issue:Suppl1

    Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Male; Rats;

2016
The protective effects of social bonding on behavioral and pituitary-adrenal axis reactivity to chronic mild stress in prairie voles.
    Stress (Amsterdam, Netherlands), 2017, Volume: 20, Issue:2

    Topics: Adrenocorticotropic Hormone; Animals; Arvicolinae; Behavior, Animal; Corticosterone; Depression; Fem

2017
Susceptibility or resilience? Prenatal stress predisposes male rats to social subordination, but facilitates adaptation to subordinate status.
    Physiology & behavior, 2017, Sep-01, Volume: 178

    Topics: Adaptation, Psychological; Adrenal Glands; Animals; Behavior, Animal; Brain; Corticosterone; Depress

2017
Chronic corticosterone administration effects on behavioral emotionality in female c57bl6 mice.
    Experimental and clinical psychopharmacology, 2017, Volume: 25, Issue:2

    Topics: Animals; Behavior, Animal; Cell Proliferation; Corticosterone; Depression; Depressive Disorder, Majo

2017
Agmatine attenuates chronic unpredictable mild stress-induced anxiety, depression-like behaviours and cognitive impairment by modulating nitrergic signalling pathway.
    Brain research, 2017, 05-15, Volume: 1663

    Topics: Agmatine; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Animal; Chronic Di

2017
Effects of Marapuama in the chronic mild stress model: further indication of antidepressant properties.
    Journal of ethnopharmacology, 2008, Jul-23, Volume: 118, Issue:2

    Topics: Animals; Antidepressive Agents; Corticosterone; Depression; Disease Models, Animal; Dose-Response Re

2008
Stress, geomagnetic disturbance, infradian and circadian sampling for circulating corticosterone and models of human depression?
    Neurotoxicity research, 2008, Volume: 13, Issue:2

    Topics: Animals; Body Weight; Chronobiology Disorders; Circadian Rhythm; Corticosterone; Depression; Dietary

2008
Moderate perinatal arsenic exposure alters neuroendocrine markers associated with depression and increases depressive-like behaviors in adult mouse offspring.
    Neurotoxicology, 2008, Volume: 29, Issue:4

    Topics: Analysis of Variance; Animals; Animals, Newborn; Arsenic; Behavior, Animal; Corticosterone; Depressi

2008
Hindlimb unloading elicits anhedonia and sympathovagal imbalance.
    Journal of applied physiology (Bethesda, Md. : 1985), 2008, Volume: 105, Issue:4

    Topics: Adrenergic beta-Antagonists; Animals; Baroreflex; Behavior, Animal; Blood Pressure; Cardiovascular D

2008
Decreased brain docosahexaenoic acid content produces neurobiological effects associated with depression: Interactions with reproductive status in female rats.
    Psychoneuroendocrinology, 2008, Volume: 33, Issue:9

    Topics: Adaptation, Physiological; alpha-Linolenic Acid; Analysis of Variance; Animals; Brain; Brain Chemist

2008
Aging increases the susceptibility to develop anhedonia in male rats.
    Progress in neuro-psychopharmacology & biological psychiatry, 2008, Dec-12, Volume: 32, Issue:8

    Topics: Aging; Analysis of Variance; Animals; Chronic Disease; Conditioning, Operant; Corticosterone; Depres

2008
Remodeling of hippocampal spine synapses in the rat learned helplessness model of depression.
    Biological psychiatry, 2009, Mar-01, Volume: 65, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents, Tricyclic; Biomarkers, Pharmacological; Co

2009
Chronically restricted sleep leads to depression-like changes in neurotransmitter receptor sensitivity and neuroendocrine stress reactivity in rats.
    Sleep, 2008, Volume: 31, Issue:11

    Topics: Animals; Conditioning, Psychological; Corticosterone; Corticotropin-Releasing Hormone; Depression; F

2008
Behavioral despair and home-cage activity in mice with chronically elevated baseline corticosterone concentrations.
    Behavior genetics, 2009, Volume: 39, Issue:2

    Topics: Animals; Behavior; Behavior, Animal; Corticosterone; Depression; Female; Genetic Predisposition to D

2009
Central nervous action of interleukin-1 mediates activation of limbic structures and behavioural depression in response to peripheral administration of bacterial lipopolysaccharide.
    The European journal of neuroscience, 2008, Volume: 28, Issue:12

    Topics: Animals; Behavior, Animal; Body Temperature; Body Weight; Brain; Corticosterone; Depression; Fever;

2008
Corticosterone regulates pERK1/2 map kinase in a chronic depression model.
    Annals of the New York Academy of Sciences, 2008, Volume: 1148

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Conditioning, O

2008
Progesterone modulation of alpha5 nAChR subunits influences anxiety-related behavior during estrus cycle.
    Genes, brain, and behavior, 2009, Volume: 8, Issue:4

    Topics: Animals; Anxiety; Behavior, Animal; Cells, Cultured; Corticosterone; Corticotropin-Releasing Hormone

2009
Antidepressant-like effects of melatonin in the mouse chronic mild stress model.
    European journal of pharmacology, 2009, Apr-01, Volume: 607, Issue:1-3

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Chronic Disease; Circadian Rhythm; Corticosterone;

2009
Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy.
    Neurobiology of disease, 2009, Volume: 34, Issue:3

    Topics: Animals; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Electrodes, Implanted

2009
Maternal postpartum learned helplessness (LH) affects maternal care by dams and responses to the LH test in adolescent offspring.
    Hormones and behavior, 2009, Volume: 56, Issue:1

    Topics: Animals; Anxiety; Body Weight; Brain-Derived Neurotrophic Factor; Breast Feeding; Corticosterone; De

2009
Long-term anxiolytic and antidepressant-like behavioural effects of tiagabine, a selective GABA transporter-1 (GAT-1) inhibitor, coincide with a decrease in HPA system activity in C57BL/6 mice.
    Journal of psychopharmacology (Oxford, England), 2010, Volume: 24, Issue:5

    Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Arginine Vasopressin; Corticosterone;

2010
Delayed stress-induced differences in locomotor and depression-related behaviour in female neuropeptide-Y Y1 receptor knockout mice.
    Journal of psychopharmacology (Oxford, England), 2010, Volume: 24, Issue:10

    Topics: Analgesia; Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Female; Mice; Mice, 129 S

2010
Gender-specific impact of brain-derived neurotrophic factor signaling on stress-induced depression-like behavior.
    Biological psychiatry, 2009, Jul-01, Volume: 66, Issue:1

    Topics: Analysis of Variance; Animals; Body Weight; Brain-Derived Neurotrophic Factor; Corticosterone; Depre

2009
Repeated exposure to corticosterone increases depression-like behavior in two different versions of the forced swim test without altering nonspecific locomotor activity or muscle strength.
    Physiology & behavior, 2009, Aug-04, Volume: 98, Issue:1-2

    Topics: Animals; Behavior, Animal; Body Weight; Corticosterone; Depression; Hand Strength; Male; Motor Activ

2009
Suppressive effect of quercetin on acute stress-induced hypothalamic-pituitary-adrenal axis response in Wistar rats.
    The Journal of nutritional biochemistry, 2010, Volume: 21, Issue:5

    Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Corticosterone; Corticotropin-Releasing

2010
Effects of acupuncture on chronic corticosterone-induced depression-like behavior and expression of neuropeptide Y in the rats.
    Neuroscience letters, 2009, Apr-10, Volume: 453, Issue:3

    Topics: Acupuncture Therapy; Animals; Anxiety; Behavior, Animal; Chronic Disease; Corticosterone; Depression

2009
Preventive action of Kai Xin San aqueous extract on depressive-like symptoms and cognition deficit induced by chronic mild stress.
    Experimental biology and medicine (Maywood, N.J.), 2009, Volume: 234, Issue:7

    Topics: Acetylcholinesterase; Acorus; Adrenocorticotropic Hormone; Animals; Chronic Disease; Cognition Disor

2009
Depression-like behavior in the forced swimming test in PACAP-deficient mice: amelioration by the atypical antipsychotic risperidone.
    Journal of neurochemistry, 2009, Volume: 110, Issue:2

    Topics: Animals; Antipsychotic Agents; Body Temperature; Circadian Rhythm; Corticosterone; Depression; Male;

2009
Behavior in the forced swim test and neurochemical changes in the hippocampus in young rats after 2-week zinc deprivation.
    Neurochemistry international, 2009, Volume: 55, Issue:7

    Topics: Adenosine Triphosphate; Amino Acids; Animals; Antimetabolites; Behavior, Animal; Blood Glucose; Calc

2009
Dissecting the pathophysiology of depression with a Swiss army knife.
    Neuron, 2009, May-28, Volume: 62, Issue:4

    Topics: Animals; Corticosterone; Depression; Disease Models, Animal; Fluoxetine; Hippocampus; Humans; Neurog

2009
Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression.
    Neuron, 2009, May-28, Volume: 62, Issue:4

    Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Anxiety; Arrestins; beta-Ar

2009
Sini tang prevents depression-like behavior in rats exposed to chronic unpredictable stress.
    The American journal of Chinese medicine, 2009, Volume: 37, Issue:2

    Topics: Animals; Base Sequence; Behavior, Animal; Corticosterone; Corticotropin-Releasing Hormone; Depressio

2009
Influence of light at night on murine anxiety- and depressive-like responses.
    Behavioural brain research, 2009, Dec-28, Volume: 205, Issue:2

    Topics: Animals; Anxiety; Corticosterone; Depression; Dietary Sucrose; Drinking Behavior; Light; Lighting; L

2009
Trilostane exerts antidepressive effects among wild-type, but not estrogen receptor [beta] knockout mice.
    Neuroreport, 2009, Aug-05, Volume: 20, Issue:12

    Topics: Analysis of Variance; Animals; Antidepressive Agents; Corticosterone; Depression; Dihydrotestosteron

2009
Anhedonia and altered cardiac atrial natriuretic peptide following chronic stressor and endotoxin treatment in mice.
    Psychoneuroendocrinology, 2010, Volume: 35, Issue:2

    Topics: Animals; Atrial Natriuretic Factor; Corticosterone; Depression; Dietary Sucrose; Eating; Endotoxins;

2010
Short- and long-term influences of hypoxia during early postnatal period of development on behavioral and hormonal responses in rats.
    Neuroscience letters, 2009, Oct-30, Volume: 464, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Corticosterone; Depression; Hypoxia; Pain; Pain

2009
Depressive-like parameters in sepsis survivor rats.
    Neurotoxicity research, 2010, Volume: 17, Issue:3

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Analysis of Variance; Animals; Antidepressive Agents, T

2010
Stress and IL-1beta contribute to the development of depressive-like behavior following peripheral nerve injury.
    Molecular psychiatry, 2010, Volume: 15, Issue:4

    Topics: Analysis of Variance; Animals; Corticosterone; Cytokines; Depression; Disease Models, Animal; Explor

2010
The lonely mouse: verification of a separation-induced model of depression in female mice.
    Behavioural brain research, 2010, Feb-11, Volume: 207, Issue:1

    Topics: Acoustic Stimulation; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Conditioning, Classi

2010
Ferulic acid induces neural progenitor cell proliferation in vitro and in vivo.
    Neuroscience, 2010, Jan-20, Volume: 165, Issue:2

    Topics: Aging; Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; Central Nervous System Ag

2010
High susceptibility to chronic social stress is associated with a depression-like phenotype.
    Psychoneuroendocrinology, 2010, Volume: 35, Issue:5

    Topics: Animals; Anxiety; Behavior, Animal; Body Weight; Brain; Corticosterone; Corticotropin-Releasing Horm

2010
Stress-related endocrinological and psychopathological effects of short- and long-term 50Hz electromagnetic field exposure in rats.
    Brain research bulletin, 2010, Jan-15, Volume: 81, Issue:1

    Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Blood Glucose; Body Weight; Chronic Disease; Corticos

2010
Dynamic DNA methylation programs persistent adverse effects of early-life stress.
    Nature neuroscience, 2009, Volume: 12, Issue:12

    Topics: Animals; Animals, Newborn; Arginine Vasopressin; Behavior, Animal; Corticosterone; Depression; DNA M

2009
Anti-depressant and anxiolytic like behaviors in PKCI/HINT1 knockout mice associated with elevated plasma corticosterone level.
    BMC neuroscience, 2009, Nov-13, Volume: 10

    Topics: Analysis of Variance; Animals; Anxiety; Avoidance Learning; Behavior, Animal; Corticosterone; Cues;

2009
Physical stress differs from psychosocial stress in the pattern and time-course of behavioral responses, serum corticosterone and expression of plasticity-related genes in the rat.
    Stress (Amsterdam, Netherlands), 2009, Volume: 12, Issue:5

    Topics: Amygdala; Animals; Anxiety; Behavior, Animal; Corticosterone; Cyclic AMP Response Element-Binding Pr

2009
Circadian phase and sex effects on depressive/anxiety-like behaviors and HPA axis responses to acute stress.
    Physiology & behavior, 2010, Mar-03, Volume: 99, Issue:3

    Topics: Animals; Anxiety; Circadian Rhythm; Corticosterone; Depression; Disease Models, Animal; Female; Hypo

2010
Palatable cafeteria diet ameliorates anxiety and depression-like symptoms following an adverse early environment.
    Psychoneuroendocrinology, 2010, Volume: 35, Issue:5

    Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Animals; Anxiety; Corticosterone; Corticotropin-Releasi

2010
Shaping brain development: mouse communal nesting blunts adult neuroendocrine and behavioral response to social stress and modifies chronic antidepressant treatment outcome.
    Psychoneuroendocrinology, 2010, Volume: 35, Issue:5

    Topics: Animals; Behavior, Animal; Brain; Corticosterone; Depression; Drug Administration Schedule; Female;

2010
Maternal and genetic factors in stress-resilient and -vulnerable rats: a cross-fostering study.
    Brain research, 2010, Feb-26, Volume: 1316

    Topics: Adrenal Glands; Aging; Animals; Anxiety; Body Weight; Corticosterone; Depression; Feeding Behavior;

2010
Interferon-gamma deficiency modifies the effects of a chronic stressor in mice: Implications for psychological pathology.
    Brain, behavior, and immunity, 2010, Volume: 24, Issue:3

    Topics: Animals; Anxiety; Behavior, Animal; Biogenic Monoamines; Brain; Chromatography, High Pressure Liquid

2010
Ambiguous-cue interpretation is biased under stress- and depression-like states in rats.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010, Volume: 35, Issue:4

    Topics: Adrenergic Uptake Inhibitors; Amygdala; Analysis of Variance; Animals; Behavior, Animal; Bias; Condi

2010
F15599, a highly selective post-synaptic 5-HT(1A) receptor agonist: in-vivo profile in behavioural models of antidepressant and serotonergic activity.
    The international journal of neuropsychopharmacology, 2010, Volume: 13, Issue:10

    Topics: Aminopyridines; Animals; Antidepressive Agents; Corticosterone; Depression; Hypothermia; Male; Model

2010
The 5-HT(7) receptor as a mediator and modulator of antidepressant-like behavior.
    Behavioural brain research, 2010, May-01, Volume: 209, Issue:1

    Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Aripiprazole; Citalopram; Corticosterone; Depr

2010
Mifepristone decreases depression-like behavior and modulates neuroendocrine and central hypothalamic-pituitary-adrenocortical axis responsiveness to stress.
    Psychoneuroendocrinology, 2010, Volume: 35, Issue:7

    Topics: Adrenocorticotropic Hormone; Amygdala; Animals; Corticosterone; Depression; Hippocampus; Hypothalamo

2010
Macrophage migration inhibitory factor is critically involved in basal and fluoxetine-stimulated adult hippocampal cell proliferation and in anxiety, depression, and memory-related behaviors.
    Molecular psychiatry, 2011, Volume: 16, Issue:5

    Topics: Acoustic Stimulation; Animals; Antidepressive Agents, Second-Generation; Anxiety; Bromodeoxyuridine;

2011
Interactions between age, stress and insulin on cognition: implications for Alzheimer's disease.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010, Volume: 35, Issue:8

    Topics: Aging; Amyloid beta-Peptides; Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Cognitio

2010
Low dose dexamethasone reverses depressive-like parameters and memory impairment in rats submitted to sepsis.
    Neuroscience letters, 2010, 04-05, Volume: 473, Issue:2

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Anti-Inflammatory Agents; Avoidance Learning;

2010
Circadian activity of corticosterone in an animal model of depression: response to muscarinic cholinergic stimulation.
    Physiology & behavior, 2010, Jun-16, Volume: 100, Issue:4

    Topics: Animals; Animals, Newborn; Antidepressive Agents, Second-Generation; Behavior, Animal; Cholinergic A

2010
The suitability of 129SvEv mice for studying depressive-like behaviour: both males and females develop learned helplessness.
    Behavioural brain research, 2010, Jul-29, Volume: 211, Issue:1

    Topics: Analysis of Variance; Animals; Behavior, Animal; Behavioral Research; Corticosterone; Depression; Di

2010
"Green odor" inhalation by stressed rat dams reduces behavioral and neuroendocrine signs of prenatal stress in the offspring.
    Hormones and behavior, 2010, Volume: 58, Issue:2

    Topics: Administration, Inhalation; Adrenal Glands; Adrenocorticotropic Hormone; Aldehydes; Animals; Body We

2010
Evaluating the interaction between early postnatal inflammation and maternal care in the programming of adult anxiety and depression-related behaviors.
    Behavioural brain research, 2010, Nov-12, Volume: 213, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Anxiety; Corticosterone; Depression; Female; Inflammation; Lipopol

2010
Resistance to the development of stress-induced behavioral despair in the forced swim test associated with elevated hippocampal Bcl-xl expression.
    Behavioural brain research, 2010, Dec-01, Volume: 213, Issue:2

    Topics: Adrenocorticotropic Hormone; Animals; bcl-2-Associated X Protein; bcl-X Protein; Brain-Derived Neuro

2010
Exercise effects on motor and affective behavior and catecholamine neurochemistry in the MPTP-lesioned mouse.
    Behavioural brain research, 2010, Dec-01, Volume: 213, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anxiety; Behavior, Animal; Brain; Corticoster

2010
Antidepressant effects of the extract YZ-50 from Polygala tenuifolia in chronic mild stress treated rats and its possible mechanisms.
    Pharmaceutical biology, 2010, Volume: 48, Issue:7

    Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Cort

2010
Chronic corticosterone during pregnancy and postpartum affects maternal care, cell proliferation and depressive-like behavior in the dam.
    Hormones and behavior, 2010, Volume: 58, Issue:5

    Topics: Algorithms; Animals; Behavior, Animal; Brain; Cell Proliferation; Corticosterone; Depression; Depres

2010
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.
    Neuroscience, 2010, Nov-10, Volume: 170, Issue:4

    Topics: Animals; Antidepressive Agents; Arginine Vasopressin; Behavior, Animal; Bifidobacterium; Biogenic Mo

2010
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.
    Neuroscience, 2010, Nov-10, Volume: 170, Issue:4

    Topics: Animals; Antidepressive Agents; Arginine Vasopressin; Behavior, Animal; Bifidobacterium; Biogenic Mo

2010
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.
    Neuroscience, 2010, Nov-10, Volume: 170, Issue:4

    Topics: Animals; Antidepressive Agents; Arginine Vasopressin; Behavior, Animal; Bifidobacterium; Biogenic Mo

2010
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.
    Neuroscience, 2010, Nov-10, Volume: 170, Issue:4

    Topics: Animals; Antidepressive Agents; Arginine Vasopressin; Behavior, Animal; Bifidobacterium; Biogenic Mo

2010
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.
    Neuroscience, 2010, Nov-10, Volume: 170, Issue:4

    Topics: Animals; Antidepressive Agents; Arginine Vasopressin; Behavior, Animal; Bifidobacterium; Biogenic Mo

2010
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.
    Neuroscience, 2010, Nov-10, Volume: 170, Issue:4

    Topics: Animals; Antidepressive Agents; Arginine Vasopressin; Behavior, Animal; Bifidobacterium; Biogenic Mo

2010
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.
    Neuroscience, 2010, Nov-10, Volume: 170, Issue:4

    Topics: Animals; Antidepressive Agents; Arginine Vasopressin; Behavior, Animal; Bifidobacterium; Biogenic Mo

2010
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.
    Neuroscience, 2010, Nov-10, Volume: 170, Issue:4

    Topics: Animals; Antidepressive Agents; Arginine Vasopressin; Behavior, Animal; Bifidobacterium; Biogenic Mo

2010
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.
    Neuroscience, 2010, Nov-10, Volume: 170, Issue:4

    Topics: Animals; Antidepressive Agents; Arginine Vasopressin; Behavior, Animal; Bifidobacterium; Biogenic Mo

2010
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.
    Neuroscience, 2010, Nov-10, Volume: 170, Issue:4

    Topics: Animals; Antidepressive Agents; Arginine Vasopressin; Behavior, Animal; Bifidobacterium; Biogenic Mo

2010
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.
    Neuroscience, 2010, Nov-10, Volume: 170, Issue:4

    Topics: Animals; Antidepressive Agents; Arginine Vasopressin; Behavior, Animal; Bifidobacterium; Biogenic Mo

2010
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.
    Neuroscience, 2010, Nov-10, Volume: 170, Issue:4

    Topics: Animals; Antidepressive Agents; Arginine Vasopressin; Behavior, Animal; Bifidobacterium; Biogenic Mo

2010
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.
    Neuroscience, 2010, Nov-10, Volume: 170, Issue:4

    Topics: Animals; Antidepressive Agents; Arginine Vasopressin; Behavior, Animal; Bifidobacterium; Biogenic Mo

2010
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.
    Neuroscience, 2010, Nov-10, Volume: 170, Issue:4

    Topics: Animals; Antidepressive Agents; Arginine Vasopressin; Behavior, Animal; Bifidobacterium; Biogenic Mo

2010
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.
    Neuroscience, 2010, Nov-10, Volume: 170, Issue:4

    Topics: Animals; Antidepressive Agents; Arginine Vasopressin; Behavior, Animal; Bifidobacterium; Biogenic Mo

2010
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.
    Neuroscience, 2010, Nov-10, Volume: 170, Issue:4

    Topics: Animals; Antidepressive Agents; Arginine Vasopressin; Behavior, Animal; Bifidobacterium; Biogenic Mo

2010
Evidence of female-specific glial deficits in the hippocampus in a mouse model of prenatal stress.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2011, Volume: 21, Issue:1

    Topics: Animals; Anxiety; Behavior, Animal; Cognition; Corticosterone; Depression; Disease Models, Animal; F

2011
Comparison of the antidepressant sertraline on differential depression-like behaviors elicited by restraint stress and repeated corticosterone administration.
    Pharmacology, biochemistry, and behavior, 2010, Volume: 97, Issue:2

    Topics: Adrenal Glands; Animals; Antidepressive Agents, Second-Generation; Anxiety; Avoidance Learning; Cond

2010
Reelin as a putative vulnerability factor for depression: examining the depressogenic effects of repeated corticosterone in heterozygous reeler mice.
    Neuropharmacology, 2011, Volume: 60, Issue:7-8

    Topics: Animals; Anti-Inflammatory Agents; Behavior, Animal; Brain; Cell Adhesion Molecules, Neuronal; Corti

2011
Antidepressant-like effect of mitragynine isolated from Mitragyna speciosa Korth in mice model of depression.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2011, Mar-15, Volume: 18, Issue:5

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal

2011
Lack of vasopressin does not prevent the behavioural and endocrine changes induced by chronic unpredictable stress.
    Brain research bulletin, 2011, Jan-15, Volume: 84, Issue:1

    Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Behavior, Animal; Body Weight; Corticosterone; Depres

2011
Vulnerability to chronic subordination stress-induced depression-like disorders in adult 129SvEv male mice.
    Progress in neuro-psychopharmacology & biological psychiatry, 2011, Aug-01, Volume: 35, Issue:6

    Topics: Aggression; Animals; Anxiety; Chronic Disease; Corticosterone; Depression; Disease Models, Animal; D

2011
Chronic corticosterone administration from adolescence through early adulthood attenuates depression-like behaviors in mice.
    Journal of affective disorders, 2011, Volume: 131, Issue:1-3

    Topics: Aging; Animals; Blotting, Western; Cell Proliferation; Corticosterone; Depression; Hippocampus; Hypo

2011
Changes in adaptability following perinatal morphine exposure in juvenile and adult rats.
    European journal of pharmacology, 2011, Mar-05, Volume: 654, Issue:2

    Topics: Adaptation, Psychological; Adrenocorticotropic Hormone; Analgesics, Opioid; Animals; Anxiety; Behavi

2011
Protective effects of flavonoid extract from Apocynum venetum leaves against corticosterone-induced neurotoxicity in PC12 cells.
    Cellular and molecular neurobiology, 2011, Volume: 31, Issue:3

    Topics: Animals; Apocynum; Calcium; Corticosterone; Depression; Disease Models, Animal; Flavonoids; L-Lactat

2011
Chronic ω-3 fatty acids supplementation promotes beneficial effects on anxiety, cognitive and depressive-like behaviors in rats subjected to a restraint stress protocol.
    Behavioural brain research, 2011, May-16, Volume: 219, Issue:1

    Topics: Affect; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Animal; Cognition; C

2011
Phenotypic characterization of a genetically diverse panel of mice for behavioral despair and anxiety.
    PloS one, 2010, Dec-29, Volume: 5, Issue:12

    Topics: Animals; Anxiety; Behavior, Animal; Brain; Brain Mapping; Corticosterone; Depression; Disease Models

2010
Early and delayed effects of hypoxia during the infantile period on behavioral and hormonal reactions of rats.
    Bulletin of experimental biology and medicine, 2010, Volume: 149, Issue:4

    Topics: Aging; Animals; Behavior, Animal; Corticosterone; Depression; Hypothalamo-Hypophyseal System; Hypoxi

2010
A role for glucocorticoid-signaling in depression-like behavior of gastrin-releasing peptide receptor knock-out mice.
    Annals of medicine, 2011, Volume: 43, Issue:5

    Topics: Amygdala; Animals; Behavior, Animal; Corticosterone; Depression; Dexamethasone; Disease Models, Anim

2011
Icariin attenuates social defeat-induced down-regulation of glucocorticoid receptor in mice.
    Pharmacology, biochemistry, and behavior, 2011, Volume: 98, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal

2011
Hypericum perforatum treatment: effect on behaviour and neurogenesis in a chronic stress model in mice.
    BMC complementary and alternative medicine, 2011, Jan-27, Volume: 11

    Topics: Animals; Anxiety; Behavior, Animal; Cell Proliferation; Corticosterone; Dendrites; Depression; Disea

2011
Curcumin reverses corticosterone-induced depressive-like behavior and decrease in brain BDNF levels in rats.
    Neuroscience letters, 2011, Apr-15, Volume: 493, Issue:3

    Topics: Animals; Antidepressive Agents; Brain; Brain-Derived Neurotrophic Factor; Corticosterone; Curcumin;

2011
Effect of fish oil and coconut fat supplementation on depressive-type behavior and corticosterone levels of prenatally stressed male rats.
    Brain research, 2011, Apr-18, Volume: 1385

    Topics: Animals; Biomarkers; Cocos; Corticosterone; Depression; Dietary Fats; Female; Fish Oils; Male; Pregn

2011
Stress and the pregnant female: Impact on hippocampal cell proliferation, but not affective-like behaviors.
    Hormones and behavior, 2011, Volume: 59, Issue:4

    Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Cell Proliferation; Corticosterone; Depres

2011
Cognitive and locomotor/exploratory behavior after chronic exercise in the olfactory bulbectomy animal model of depression.
    Behavioural brain research, 2011, Sep-12, Volume: 222, Issue:1

    Topics: Animals; Body Weight; Cognition; Conditioning, Psychological; Corticosterone; Depression; Disease Mo

2011
Low dietary sodium is anxiogenic in rats.
    Physiology & behavior, 2011, Jul-06, Volume: 103, Issue:5

    Topics: Animals; Anxiety; Body Weight; Corticosterone; Depression; Disease Models, Animal; Food Preferences;

2011
Altered aortic vascular reactivity in the unpredictable chronic mild stress model of depression in mice: UCMS causes relaxation impairment to ACh.
    Physiology & behavior, 2011, Jul-06, Volume: 103, Issue:5

    Topics: Acetylcholine; Animals; Aorta; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal;

2011
Do stress hormones connect environmental effects with behavior in the forced swim test?
    Endocrine journal, 2011, Volume: 58, Issue:5

    Topics: Adaptation, Psychological; Adrenocorticotropic Hormone; Animals; Behavior, Animal; Body Temperature;

2011
Dietary arginine depletion reduces depressive-like responses in male, but not female, mice.
    Behavioural brain research, 2011, Sep-30, Volume: 223, Issue:1

    Topics: Aggression; Animals; Anxiety; Arginine; Body Weight; Corticosterone; Depression; Disease Models, Ani

2011
Antidepressants recruit new neurons to improve stress response regulation.
    Molecular psychiatry, 2011, Volume: 16, Issue:12

    Topics: Animals; Antidepressive Agents; Cell Count; Corticosterone; Depression; Dexamethasone; Disease Model

2011
Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice.
    Molecular psychiatry, 2012, Volume: 17, Issue:7

    Topics: Animals; Behavior, Animal; Biomarkers; Corticosterone; Depression; Disease Models, Animal; Extracell

2012
Electromagnetic field effect or simply stress? Effects of UMTS exposure on hippocampal longterm plasticity in the context of procedure related hormone release.
    PloS one, 2011, May-05, Volume: 6, Issue:5

    Topics: Adrenocorticotropic Hormone; Animals; Corticosterone; Depression; Electromagnetic Fields; Electrophy

2011
Effects of octreotide in chronically mild stressed rats: possible role of immune and oxidative stress pathways.
    Neurochemical research, 2011, Volume: 36, Issue:10

    Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Antineoplastic Agents, Hormonal; Antiox

2011
Behavioural and neurochemical evaluation of Perment an herbal formulation in chronic unpredictable mild stress induced depressive model.
    Indian journal of experimental biology, 2011, Volume: 49, Issue:4

    Topics: Animals; Behavior, Animal; Chronic Disease; Corticosterone; Depression; Disease Models, Animal; Expl

2011
Chronic juvenile stress produces corticolimbic dendritic architectural remodeling and modulates emotional behavior in male and female rats.
    Psychoneuroendocrinology, 2012, Volume: 37, Issue:1

    Topics: Adaptation, Psychological; Amygdala; Anhedonia; Animals; Chronic Disease; Corticosterone; Dendrites;

2012
Prolonged depression-like behavior caused by immune challenge: influence of mouse strain and social environment.
    PloS one, 2011, Volume: 6, Issue:6

    Topics: Animals; Behavior, Animal; Body Weight; Corticosterone; Depression; Female; Food Preferences; Housin

2011
Paternal transmission of stress-induced pathologies.
    Biological psychiatry, 2011, Sep-01, Volume: 70, Issue:5

    Topics: Animals; Anxiety; Corticosterone; Depression; Disease Models, Animal; Father-Child Relations; Father

2011
Association between Na⁺,K⁺-ATPase activity and the vulnerability/resilience to mood disorders induced by early life experience.
    Neurochemical research, 2011, Volume: 36, Issue:11

    Topics: Adaptation, Psychological; Amygdala; Animals; Animals, Newborn; Blood Glucose; Corticosterone; Depre

2011
High-fat diet selectively protects against the effects of chronic social stress in the mouse.
    Neuroscience, 2011, Sep-29, Volume: 192

    Topics: Animals; Anxiety; Corticosterone; Depression; Diet, High-Fat; Female; Insulin; Leptin; Male; Mice; M

2011
Organic cation transporter 2 controls brain norepinephrine and serotonin clearance and antidepressant response.
    Molecular psychiatry, 2012, Volume: 17, Issue:9

    Topics: Action Potentials; Animals; Antidepressive Agents, Second-Generation; Anxiety; Brain; Corticosterone

2012
Site-specific genetic manipulation of amygdala corticotropin-releasing factor reveals its imperative role in mediating behavioral response to challenge.
    Biological psychiatry, 2012, Feb-15, Volume: 71, Issue:4

    Topics: Amygdala; Animals; Anxiety; Behavior, Animal; Corticosterone; Corticotropin-Releasing Hormone; Depre

2012
Adult hippocampal neurogenesis buffers stress responses and depressive behaviour.
    Nature, 2011, Aug-03, Volume: 476, Issue:7361

    Topics: Animals; Behavior, Animal; Corticosterone; Dentate Gyrus; Depression; Dexamethasone; Glucocorticoids

2011
Are different biological mechanisms involved in the transmission of maternal versus paternal stress-induced vulnerability to offspring?
    Biological psychiatry, 2011, Sep-01, Volume: 70, Issue:5

    Topics: Animals; Anxiety; Corticosterone; Depression; Disease Models, Animal; Father-Child Relations; Father

2011
Differential effects of prenatal stress in 5-Htt deficient mice: towards molecular mechanisms of gene × environment interactions.
    PloS one, 2011, Volume: 6, Issue:8

    Topics: Analysis of Variance; Animals; Animals, Newborn; Anxiety; Cognition; Corticosterone; Depression; Fem

2011
Gestational and postpartum corticosterone exposure to the dam affects behavioral and endocrine outcome of the offspring in a sexually-dimorphic manner.
    Neuropharmacology, 2012, Volume: 62, Issue:1

    Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Cell Proliferation;

2012
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Sep-20, Volume: 108, Issue:38

    Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression

2011
Luteolin shows an antidepressant-like effect via suppressing endoplasmic reticulum stress.
    Biological & pharmaceutical bulletin, 2011, Volume: 34, Issue:9

    Topics: Animals; Antidepressive Agents; Blotting, Western; Caspase 3; Cell Line, Tumor; Corticosterone; Depr

2011
Behavioral sexual dimorphism in models of anxiety and depression due to changes in HPA axis activity.
    Neuropharmacology, 2012, Volume: 62, Issue:1

    Topics: Adrenalectomy; Analysis of Variance; Animals; Anxiety; Corticosterone; Dark Adaptation; Depression;

2012
Maternal infection during late pregnancy increases anxiety- and depression-like behaviors with increasing age in male offspring.
    Brain research bulletin, 2012, Feb-10, Volume: 87, Issue:2-3

    Topics: Age Factors; Analysis of Variance; Animals; Anxiety; Corticosterone; Cytokines; Depression; Dose-Res

2012
Permanent relief from intermittent cold stress-induced fibromyalgia-like abnormal pain by repeated intrathecal administration of antidepressants.
    Molecular pain, 2011, Sep-21, Volume: 7

    Topics: Analgesics; Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Body Weight; Cold Temperature

2011
A single subanesthetic dose of ketamine relieves depression-like behaviors induced by neuropathic pain in rats.
    Anesthesiology, 2011, Volume: 115, Issue:4

    Topics: Anesthetics, Dissociative; Animals; Antidepressive Agents; Behavior, Animal; Cold Temperature; Corti

2011
Depressive phenotypes evoked by experimental diabetes are reversed by insulin.
    Physiology & behavior, 2012, Feb-01, Volume: 105, Issue:3

    Topics: Analysis of Variance; Animals; Blood Glucose; Brain; Brain-Derived Neurotrophic Factor; Bromodeoxyur

2012
Green tea polyphenols produce antidepressant-like effects in adult mice.
    Pharmacological research, 2012, Volume: 65, Issue:1

    Topics: Administration, Oral; Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Camellia sinensis

2012
Social deprivation stress is a triggering factor for the emergence of anxiety- and depression-like behaviours and leads to reduced brain BDNF levels in C57BL/6J mice.
    Psychoneuroendocrinology, 2012, Volume: 37, Issue:6

    Topics: Adrenal Glands; Anhedonia; Animals; Anxiety; Behavior, Animal; Body Weight; Brain Chemistry; Brain-D

2012
Exposure to enriched environment restores the mRNA expression of mineralocorticoid and glucocorticoid receptors in the hippocampus and ameliorates depressive-like symptoms in chronically stressed rats.
    Current neurovascular research, 2011, Volume: 8, Issue:4

    Topics: Animals; Body Weight; Corticosterone; Depression; Disease Models, Animal; Environment; Exploratory B

2011
Functional status of somatodendritic serotonin 1A autoreceptor after long-term treatment with fluoxetine in a mouse model of anxiety/depression based on repeated corticosterone administration.
    Molecular pharmacology, 2012, Volume: 81, Issue:2

    Topics: Animals; Anxiety; Autoreceptors; Corticosterone; Depression; Drug Resistance; Drug Therapy, Combinat

2012
Cysteamine attenuates the decreases in TrkB protein levels and the anxiety/depression-like behaviors in mice induced by corticosterone treatment.
    PloS one, 2011, Volume: 6, Issue:10

    Topics: Animals; Anxiety; Corticosterone; Cysteamine; Depression; Mice; Mice, Knockout; Receptor, trkB

2011
Origin and consequences of brain Toll-like receptor 4 pathway stimulation in an experimental model of depression.
    Journal of neuroinflammation, 2011, Nov-03, Volume: 8

    Topics: Animals; Anti-Bacterial Agents; Behavior, Animal; Brain; Corticosterone; Depression; Encephalitis; I

2011
Sub-chronic dietary tryptophan depletion--an animal model of depression with improved face and good construct validity.
    Journal of psychiatric research, 2012, Volume: 46, Issue:2

    Topics: Aldosterone; Analysis of Variance; Animals; Body Weight; Brain; Calcium-Binding Proteins; Catecholam

2012
Exposure to repeated maternal aggression induces depressive-like behavior and increases startle in adult female rats.
    Behavioural brain research, 2012, Feb-01, Volume: 227, Issue:1

    Topics: Acoustic Stimulation; Aggression; Analysis of Variance; Animals; Corticosterone; Depression; Estrous

2012
Lack of elevations in glucocorticoids correlates with dysphoria-like behavior after repeated social defeat.
    Physiology & behavior, 2012, Feb-28, Volume: 105, Issue:4

    Topics: Adrenal Glands; Anhedonia; Animals; Anxiety; CA2 Region, Hippocampal; Corticosterone; Depression; Di

2012
Peony glycosides reverse the effects of corticosterone on behavior and brain BDNF expression in rats.
    Behavioural brain research, 2012, Feb-01, Volume: 227, Issue:1

    Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Brain; Br

2012
Juvenile social subjugation induces a sex-specific pattern of anxiety and depression-like behaviors in adult rats.
    Hormones and behavior, 2012, Volume: 61, Issue:1

    Topics: Adrenal Glands; Aggression; Animals; Anxiety; Corticosterone; Depression; Female; Male; Organ Size;

2012
Reorganization of synaptic inputs to the hypothalamic paraventricular nucleus during chronic psychogenic stress in rats.
    Biological psychiatry, 2012, Feb-15, Volume: 71, Issue:4

    Topics: Animals; Behavioral Symptoms; Chronic Disease; Corticosterone; Corticotropin-Releasing Hormone; Depr

2012
Ascorbic acid treatment, similarly to fluoxetine, reverses depressive-like behavior and brain oxidative damage induced by chronic unpredictable stress.
    Journal of psychiatric research, 2012, Volume: 46, Issue:3

    Topics: Animals; Antidepressive Agents; Antioxidants; Ascorbic Acid; Catalase; Cerebral Cortex; Corticostero

2012
Beneficial effects of benzodiazepine diazepam on chronic stress-induced impairment of hippocampal structural plasticity and depression-like behavior in mice.
    Behavioural brain research, 2012, Mar-17, Volume: 228, Issue:2

    Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Brain-Derived Neurotrophic Factor; Corticosteron

2012
Protective effects of piperine against corticosterone-induced neurotoxicity in PC12 cells.
    Cellular and molecular neurobiology, 2012, Volume: 32, Issue:4

    Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Antidepressive Agents; Benzodioxoles; Corticosterone;

2012
Deletion of forebrain glucocorticoid receptors impairs neuroendocrine stress responses and induces depression-like behavior in males but not females.
    Neuroscience, 2012, Feb-17, Volume: 203

    Topics: Animals; Behavior, Animal; Choice Behavior; Corticosterone; Depression; Female; Hypothalamo-Hypophys

2012
Circadian activity of the hypothalamic-pituitary-adrenal axis is differentially affected in the rat chronic mild stress model of depression.
    Stress (Amsterdam, Netherlands), 2012, Volume: 15, Issue:6

    Topics: Animals; Circadian Rhythm; Corticosterone; Depression; Dexamethasone; Feces; Hypothalamo-Hypophyseal

2012
Corticosterone reduces brain mitochondrial function and expression of mitofusin, BDNF in depression-like rodents regardless of exercise preconditioning.
    Psychoneuroendocrinology, 2012, Volume: 37, Issue:7

    Topics: Animals; Behavior, Animal; Brain; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Dis

2012
Long lasting effects of early-life stress on glutamatergic/GABAergic circuitry in the rat hippocampus.
    Neuropharmacology, 2012, Volume: 62, Issue:5-6

    Topics: Age Factors; Animals; Antidepressive Agents, Second-Generation; Corticosterone; Cyclohexanols; Depre

2012
Prenatal stress effects on emotion regulation differ by genotype and sex in prepubertal rats.
    Developmental psychobiology, 2013, Volume: 55, Issue:2

    Topics: Animals; Corticosterone; Depression; Emotions; Female; Genotype; Male; Pregnancy; Prenatal Exposure

2013
Behavioral training and predisposed coping strategies interact to influence resilience in male Long-Evans rats: implications for depression.
    Stress (Amsterdam, Netherlands), 2012, Volume: 15, Issue:3

    Topics: Adaptation, Psychological; Animals; Anxiety; Behavior, Animal; Brain; Brain Chemistry; Corticosteron

2012
Antidepressant-like effects of ginsenoside Rg1 are due to activation of the BDNF signalling pathway and neurogenesis in the hippocampus.
    British journal of pharmacology, 2012, Volume: 166, Issue:6

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone;

2012
Intermittent physical stress during early- and mid-adolescence differentially alters rats' anxiety- and depression-like behaviors in adulthood.
    Behavioral neuroscience, 2012, Volume: 126, Issue:2

    Topics: Age Factors; Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Exploratory Behavior; F

2012
[Prenatal stressed female rats develop stable anxious and depressive state in experimental model of post-traumatic stress disorder].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2011, Volume: 97, Issue:11

    Topics: Animals; Anxiety; Corticosterone; Depression; Disease Models, Animal; Female; Humans; Hydrocortisone

2011
Chronic mild stress-induced depression-like symptoms in rats and abnormalities in catecholamine uptake in small arteries.
    Psychosomatic medicine, 2012, Volume: 74, Issue:3

    Topics: Analysis of Variance; Anhedonia; Animals; Arteries; Behavior, Animal; Blood Pressure; Catecholamines

2012
Forebrain glutamatergic neurons mediate leptin action on depression-like behaviors and synaptic depression.
    Translational psychiatry, 2012, Volume: 2

    Topics: Animals; Arousal; Cerebral Cortex; Corticosterone; Depression; Dominance-Subordination; Exploratory

2012
Hormonal and behavioural abnormalities induced by stress in utero: an animal model for depression.
    Stress (Amsterdam, Netherlands), 2001, Volume: 4, Issue:3

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Circadian Rhythm; Corticosterone; Depression; Dise

2001
Variant brain-derived neurotrophic factor Val66Met polymorphism alters vulnerability to stress and response to antidepressants.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Mar-21, Volume: 32, Issue:12

    Topics: Adrenocorticotropic Hormone; Analysis of Variance; Animals; Antidepressive Agents; Brain; Brain-Deri

2012
Bupleurum falcatum prevents depression and anxiety-like behaviors in rats exposed to repeated restraint stress.
    Journal of microbiology and biotechnology, 2012, Volume: 22, Issue:3

    Topics: Animals; Antidepressive Agents; Anxiety; Brain; Bupleurum; Corticosterone; Depression; Depressive Di

2012
Antidepressant-like activity of gallic acid in mice subjected to unpredictable chronic mild stress.
    Fundamental & clinical pharmacology, 2013, Volume: 27, Issue:4

    Topics: Animals; Antidepressive Agents; Antioxidants; Brain; Catalase; Corticosterone; Depression; Fluoxetin

2013
Exofocal dopaminergic degeneration as antidepressant target in mouse model of poststroke depression.
    Biological psychiatry, 2012, Aug-15, Volume: 72, Issue:4

    Topics: Animals; Brain-Derived Neurotrophic Factor; Citalopram; Corticosterone; Depression; Disease Models,

2012
Diet-induced obesity promotes depressive-like behaviour that is associated with neural adaptations in brain reward circuitry.
    International journal of obesity (2005), 2013, Volume: 37, Issue:3

    Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Diet, High-Fat; Disease Models, Anim

2013
Urinary biopyrrins: potential biomarker for monitoring of the response to treatment with anxiolytics.
    Basic & clinical pharmacology & toxicology, 2012, Volume: 111, Issue:3

    Topics: Alprazolam; Animals; Anti-Anxiety Agents; Bilirubin; Biomarkers; Corticosterone; Depression; Enzyme-

2012
Antinociceptive effects of fluoxetine in a mouse model of anxiety/depression.
    Neuroreport, 2012, Jun-20, Volume: 23, Issue:9

    Topics: Animals; Antidepressive Agents, Second-Generation; Anxiety; Chronic Pain; Cold Temperature; Corticos

2012
Zinc signaling in the hippocampus and its relation to pathogenesis of depression.
    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2012, Volume: 26, Issue:2-3

    Topics: Animals; Corticosterone; Depression; Glucocorticoids; Hippocampus; Male; Rats; Stress, Physiological

2012
Female early adult depression results in detrimental impacts on the behavioral performance and brain development in offspring.
    CNS neuroscience & therapeutics, 2012, Volume: 18, Issue:6

    Topics: Age Factors; Animals; Animals, Newborn; Astrocytes; Behavior, Animal; Body Weight; Brain; Bromodeoxy

2012
NPY intraperitoneal injections produce antidepressant-like effects and downregulate BDNF in the rat hypothalamus.
    CNS neuroscience & therapeutics, 2012, Volume: 18, Issue:6

    Topics: Analysis of Variance; Animals; Antidepressive Agents; Body Weight; Brain-Derived Neurotrophic Factor

2012
Different emotional disturbances in two experimental models of temporal lobe epilepsy in rats.
    PloS one, 2012, Volume: 7, Issue:6

    Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Emotions; Ep

2012
Post-training reward partially restores chronic stress induced effects in mice.
    PloS one, 2012, Volume: 7, Issue:6

    Topics: Animals; Corticosterone; Depression; Male; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Rats; Re

2012
Chronic exposure to an extremely low-frequency magnetic field induces depression-like behavior and corticosterone secretion without enhancement of the hypothalamic-pituitary-adrenal axis in mice.
    Bioelectromagnetics, 2013, Volume: 34, Issue:1

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Behavior, Animal; Body Size; Corticosterone; D

2013
Adiponectin is critical in determining susceptibility to depressive behaviors and has antidepressant-like activity.
    Proceedings of the National Academy of Sciences of the United States of America, 2012, Jul-24, Volume: 109, Issue:30

    Topics: Absorptiometry, Photon; Adiponectin; Anhedonia; Animals; Antibodies, Monoclonal; Blood Glucose; Cort

2012
Neurobiological sequelae of witnessing stressful events in adult mice.
    Biological psychiatry, 2013, Jan-01, Volume: 73, Issue:1

    Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Fluoxetine;

2013
Time course of zinc deprivation-induced alterations of mice behavior in the forced swim test.
    Pharmacological reports : PR, 2012, Volume: 64, Issue:3

    Topics: Animals; Behavior, Animal; Corticosterone; Depression; Male; Mice; Motor Activity; Swimming; Time Fa

2012
Exposure to a maternal n-3 fatty acid-deficient diet during brain development provokes excessive hypothalamic-pituitary-adrenal axis responses to stress and behavioral indices of depression and anxiety in male rat offspring later in life.
    The Journal of nutritional biochemistry, 2013, Volume: 24, Issue:1

    Topics: Animals; Anxiety; Behavior, Animal; Bicuculline; Brain; Corticosterone; Depression; Docosahexaenoic

2013
Evidence for biological roots in the transgenerational transmission of intimate partner violence.
    Translational psychiatry, 2012, Apr-24, Volume: 2

    Topics: Adult; Age Factors; Aggression; Agonistic Behavior; Animals; Anxiety; Body Weight; Child; Child Abus

2012
Depressive-like states heighten the aversion to painful stimuli in a rat model of comorbid chronic pain and depression.
    Anesthesiology, 2012, Volume: 117, Issue:3

    Topics: Animals; Chronic Pain; Corticosterone; Depression; Disease Models, Animal; Extracellular Signal-Regu

2012
Central administration of murine interferon-α induces depressive-like behavioral, brain cytokine and neurochemical alterations in mice: a mini-review and original experiments.
    Brain, behavior, and immunity, 2013, Volume: 31

    Topics: Animals; Behavior, Animal; Brain; Corticosterone; Cytokines; Depression; Gene Expression; Illness Be

2013
Persistent effects of prior chronic exposure to corticosterone on reward-related learning and motivation in rodents.
    Psychopharmacology, 2013, Volume: 225, Issue:3

    Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Conditioning, Operant; C

2013
Ethanol extracts from Hemerocallis citrina attenuate the decreases of brain-derived neurotrophic factor, TrkB levels in rat induced by corticosterone administration.
    Journal of ethnopharmacology, 2012, Nov-21, Volume: 144, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone;

2012
Three Chinese herbal medicines promote neuroproliferation in vitro, and reverse the effects of chronic mild stress on behavior, the HPA axis, and proliferation of hippocampal precursor cell in vivo.
    Journal of ethnopharmacology, 2012, Nov-21, Volume: 144, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Cell Line; Cell Proliferation; Corticosterone; Dep

2012
Adolescence fluoxetine increases serotonergic activity in the raphe-hippocampus axis and improves depression-like behaviors in female rats that experienced neonatal maternal separation.
    Psychoneuroendocrinology, 2013, Volume: 38, Issue:6

    Topics: Animals; Animals, Newborn; Behavior, Animal; Body Weight; Corticosterone; Corticotropin-Releasing Ho

2013
Metabotropic glutamate 2/3 receptor antagonists improve behavioral and prefrontal dopaminergic alterations in the chronic corticosterone-induced depression model in mice.
    Neuropharmacology, 2013, Volume: 65

    Topics: Animals; Antidepressive Agents; Corticosterone; Depression; Disease Models, Animal; Dopamine; Excita

2013
Chronic treatment with baicalin prevents the chronic mild stress-induced depressive-like behavior: involving the inhibition of cyclooxygenase-2 in rat brain.
    Progress in neuro-psychopharmacology & biological psychiatry, 2013, Jan-10, Volume: 40

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain; Corticosterone; Cyclooxygenase 2 Inhibitors

2013
Mineralocorticoid receptor antagonist spironolactone prevents chronic corticosterone induced depression-like behavior.
    Psychoneuroendocrinology, 2013, Volume: 38, Issue:6

    Topics: Animals; Behavior, Animal; Corticosterone; Depression; Hippocampus; Hydroxyindoleacetic Acid; Hypoth

2013
Individual differences in pre-carcinogen cytokine and corticosterone concentrations and depressive-like behavior predict tumor onset in rats exposed to a carcinogen.
    Psychoneuroendocrinology, 2013, Volume: 38, Issue:6

    Topics: Animals; Biomarkers; Corticosterone; Cytokines; Depression; Disease Susceptibility; Female; Individu

2013
Low maternal care exacerbates adult stress susceptibility in the chronic mild stress rat model of depression.
    Behavioural pharmacology, 2012, Volume: 23, Issue:8

    Topics: Animals; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Disease Susceptibilit

2012
Fucoidan prevents depression-like behavior in rats exposed to repeated restraint stress.
    Journal of natural medicines, 2013, Volume: 67, Issue:3

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain; Brain-Derived Neurotrophic Factor; Corticos

2013
Synaptic plasticity, but not hippocampal neurogenesis, mediated the counteractive effect of wolfberry on depression in rats(1).
    Cell transplantation, 2012, Volume: 21, Issue:12

    Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents; Antimetabolites, Antineoplastic; Corticost

2012
Aberrant light directly impairs mood and learning through melanopsin-expressing neurons.
    Nature, 2012, Nov-22, Volume: 491, Issue:7425

    Topics: Affect; Animals; Antidepressive Agents; Body Temperature Regulation; Circadian Rhythm; Cognition; Co

2012
Short-term social isolation induces depressive-like behaviour and reinstates the retrieval of an aversive task: mood-congruent memory in male mice?
    Journal of psychiatry & neuroscience : JPN, 2013, Volume: 38, Issue:4

    Topics: Affect; Animals; Avoidance Learning; Behavior, Animal; Corticosterone; Crowding; Depression; Discrim

2013
Vulnerability versus resilience to prenatal stress in male and female rats; implications from gene expression profiles in the hippocampus and frontal cortex.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2013, Volume: 23, Issue:10

    Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Disease Susceptibility; Epigenesis,

2013
Altered GABAergic and glutamatergic activity within the rat hippocampus and amygdala in rats subjected to repeated corticosterone administration but not restraint stress.
    Neuroscience, 2013, Feb-12, Volume: 231

    Topics: Amygdala; Animals; Behavior, Animal; Corticosterone; Depression; Depressive Disorder; Disease Models

2013
Pure docosahexaenoic acid can improve depression behaviors and affect HPA axis in mice.
    European review for medical and pharmacological sciences, 2012, Volume: 16, Issue:13

    Topics: Adrenocorticotropic Hormone; Animals; Corticosterone; Depression; Docosahexaenoic Acids; Fatty Acids

2012
Bidirectional crosstalk between stress-induced gastric ulcer and depression under chronic stress.
    PloS one, 2012, Volume: 7, Issue:12

    Topics: Animals; Anti-Ulcer Agents; Corticosterone; Depression; Fluoxetine; Male; Mifepristone; Ranitidine;

2012
Prenatal Enriched Environment improves emotional and attentional reactivity to adulthood stress.
    Behavioural brain research, 2013, Mar-15, Volume: 241

    Topics: Animals; Anxiety; Attention; Corticosterone; Depression; Emotions; Environment; Female; Freezing Rea

2013
Impacts of early intervention with fluoxetine following early neonatal immune activation on depression-like behaviors and body weight in mice.
    Progress in neuro-psychopharmacology & biological psychiatry, 2013, Jun-03, Volume: 43

    Topics: Aging; Animals; Animals, Newborn; Antidepressive Agents, Second-Generation; Behavior, Animal; Body W

2013
Swimming exercise ameliorates depression-like behavior in chronically stressed rats: relevant to proinflammatory cytokines and IDO activation.
    Behavioural brain research, 2013, Apr-01, Volume: 242

    Topics: Analysis of Variance; Animals; Corticosterone; Cytokines; Depression; Disease Models, Animal; Exerci

2013
Chronic subordinate colony housing (CSC) as a model of chronic psychosocial stress in male rats.
    PloS one, 2012, Volume: 7, Issue:12

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aggression; Animals; Anxiety; Behavior, Animal; Body We

2012
Coenzyme Q10 displays antidepressant-like activity with reduction of hippocampal oxidative/nitrosative DNA damage in chronically stressed rats.
    Pharmacology, biochemistry, and behavior, 2013, Volume: 104

    Topics: Animals; Antidepressive Agents; Antioxidants; Behavior, Animal; Corticosterone; Depression; Disease

2013
Alteration in plasma corticosterone levels following long term oral administration of lead produces depression like symptoms in rats.
    Metabolic brain disease, 2013, Volume: 28, Issue:1

    Topics: Administration, Oral; Animals; Brain Chemistry; Corticosterone; Depression; Eating; Lead; Male; Maze

2013
Alcohol administration blocks stress-induced impairments in memory and anxiety, and alters hippocampal neurotransmitter receptor expression in male rats.
    Hormones and behavior, 2013, Volume: 63, Issue:4

    Topics: Animals; Anxiety; Blotting, Western; Central Nervous System Depressants; Corticosterone; Depression;

2013
Flattening the corticosterone rhythm attenuates 5-HT1A autoreceptor function in the rat: relevance for depression.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2003, Volume: 28, Issue:1

    Topics: Animals; Body Weight; Circadian Rhythm; Corticosterone; Dendrites; Depression; Drug Implants; Hippoc

2003
Amphetamine withdrawal does not produce a depressive-like state in rats as measured by three behavioral tests.
    Behavioural pharmacology, 2003, Volume: 14, Issue:1

    Topics: Adrenocorticotropic Hormone; Amphetamine; Animals; Behavior, Animal; Central Nervous System Stimulan

2003
Impact of chronic intermittent challenges in stressor-susceptible and resilient strains of mice.
    Biological psychiatry, 2003, Feb-15, Volume: 53, Issue:4

    Topics: Animals; Anxiety; Behavior, Animal; Biogenic Monoamines; Brain Chemistry; Chromatography, High Press

2003
Flattening the glucocorticoid rhythm causes changes in hippocampal expression of messenger RNAs coding structural and functional proteins: implications for aging and depression.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2003, Volume: 28, Issue:5

    Topics: Aging; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Pro

2003
Topiramate normalizes hippocampal NPY-LI in flinders sensitive line 'depressed' rats and upregulates NPY, galanin, and CRH-LI in the hypothalamus: implications for mood-stabilizing and weight loss-inducing effects.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2003, Volume: 28, Issue:7

    Topics: Affect; Animals; Anticonvulsants; Corpus Striatum; Corticosterone; Corticotropin-Releasing Hormone;

2003
Implantation of a slow release corticosterone pellet induces long-term alterations in serotonergic neurochemistry in the rat brain.
    Journal of neuroendocrinology, 2003, Volume: 15, Issue:6

    Topics: Adrenal Glands; Animals; Body Weight; Carrier Proteins; Corticosterone; Depression; Disease Models,

2003
Behavioral, neurochemical, and electrophysiological characterization of a genetic mouse model of depression.
    Proceedings of the National Academy of Sciences of the United States of America, 2003, May-13, Volume: 100, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adaptation, Psychological; Animals; Antidepressive Agents; A

2003
Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2003, Volume: 28, Issue:9

    Topics: Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Bromodeoxyuridine; Cell Count;

2003
SPREADING DEPRESSION AND ADRENOCORTICAL FUNCTION IN THE ADAPTATION OF THE ORGANISM TO REPEATED SHORT-TERM STRESS.
    Activitas nervosa superior, 1964, Volume: 6

    Topics: Adaptation, Physiological; Ascorbic Acid; Brain; Cerebral Cortex; Corticosterone; Decerebrate State;

1964
Corticosterone attenuates the antidepressant-like effects elicited by melatonin in the forced swim test in both male and female rats.
    Progress in neuro-psychopharmacology & biological psychiatry, 2003, Volume: 27, Issue:6

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Drug Combinations; Dru

2003
Corticosterone and testosterone levels after chronic stress in an animal model of depression.
    Neuropsychobiology, 2003, Volume: 48, Issue:2

    Topics: Analysis of Variance; Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Behavior, Animal;

2003
Different regulation of adenylyl cyclase and rolipram-sensitive phosphodiesterase activity on the frontal cortex and hippocampus in learned helplessness rats.
    Brain research, 2003, Nov-21, Volume: 991, Issue:1-2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Corticosterone; Cyclic AMP; Cyclic

2003
Nicotine withdrawal induces subsensitivity of hypothalamic-pituitary-adrenal axis to stress in rats: implications for precipitation of depression during smoking cessation.
    Psychoneuroendocrinology, 2004, Volume: 29, Issue:2

    Topics: Adaptation, Physiological; Adrenal Cortex Function Tests; Animals; Corticosterone; Depression; Dexam

2004
Forebrain-specific trkB-receptor knockout mice: behaviorally more hyperactive than "depressive".
    Biological psychiatry, 2003, Nov-15, Volume: 54, Issue:10

    Topics: Adrenocorticotropic Hormone; Analysis of Variance; Animals; Behavior, Animal; Corticosterone; Cortic

2003
Impaired T-cell dependent humoral response and its relationship with T lymphocyte sensitivity to stress hormones in a chronic mild stress model of depression.
    Brain, behavior, and immunity, 2004, Volume: 18, Issue:1

    Topics: Analysis of Variance; Animals; Antibody Formation; Antigens; Chronic Disease; Corticosterone; Depres

2004
Total sleep deprivation decreases immobility in the forced-swim test.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2004, Volume: 29, Issue:6

    Topics: Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression;

2004
Dietary n-3 fatty acids selectively attenuate LPS-induced behavioral depression in mice.
    Physiology & behavior, 2004, Volume: 81, Issue:4

    Topics: Analysis of Variance; Animals; Behavior, Animal; Blood Glucose; Brain; Corticosterone; Depression; D

2004
Sex differences in behavioral, neurochemical and neuroendocrine effects induced by the forced swim test in rats.
    Neuroscience, 2004, Volume: 126, Issue:4

    Topics: Analysis of Variance; Animals; Behavior, Animal; Blotting, Northern; Brain Chemistry; Corticosterone

2004
Influence of chronic interleukin-2 infusion and stressors on sickness behaviors and neurochemical change in mice.
    Neuroimmunomodulation, 2004, Volume: 11, Issue:5

    Topics: Acute Disease; Animals; Anorexia; Behavior, Animal; Biogenic Monoamines; Brain; Cacao; Chronic Disea

2004
A distinct neurochemical profile in WKY rats at baseline and in response to acute stress: implications for animal models of anxiety and depression.
    Brain research, 2004, Sep-24, Volume: 1021, Issue:2

    Topics: Animals; Anxiety; Brain; Chromatography, High Pressure Liquid; Corticosterone; Depression; Disease M

2004
Effect of repeated corticosterone injections and restraint stress on anxiety and depression-like behavior in male rats.
    Behavioural brain research, 2005, Jan-06, Volume: 156, Issue:1

    Topics: Aggression; Agonistic Behavior; Animals; Anxiety; Arousal; Corticosterone; Depression; Disease Model

2005
Chronic treatment with the monoamine oxidase inhibitor phenelzine increases hypothalamic-pituitary-adrenocortical activity in male C57BL/6 mice: relevance to atypical depression.
    Endocrinology, 2005, Volume: 146, Issue:3

    Topics: Adrenal Cortex; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Analysis of Variance; Animals;

2005
Corticosterone increases depression-like behavior, with some effects on predator odor-induced defensive behavior, in male and female rats.
    Behavioral neuroscience, 2004, Volume: 118, Issue:6

    Topics: Aggression; Analysis of Variance; Animals; Behavior, Animal; Body Weight; Corticosterone; Depression

2004
Antianxiety and antidepressive behavior produced by physiological estradiol regimen may be modulated by hypothalamic-pituitary-adrenal axis activity.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005, Volume: 30, Issue:7

    Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Disease Models

2005
Effect of chronic treatment with ladostigil (TV-3326) on anxiogenic and depressive-like behaviour and on activity of the hypothalamic-pituitary-adrenal axis in male and female prenatally stressed rats.
    Psychopharmacology, 2005, Volume: 181, Issue:1

    Topics: Age Factors; Animals; Anxiety; Behavior, Animal; Cholinesterase Inhibitors; Corticosterone; Depressi

2005
Antidepressant action of agomelatine (S 20098) in a transgenic mouse model.
    Progress in neuro-psychopharmacology & biological psychiatry, 2005, Volume: 29, Issue:6

    Topics: Acetamides; Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Behavior, Animal; Corticost

2005
Two different putative genetic animal models of childhood depression.
    Biological psychiatry, 2006, Jan-01, Volume: 59, Issue:1

    Topics: Adrenocorticotropic Hormone; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Cort

2006
Prenatal restraint stress and long-term affective consequences.
    Developmental neuroscience, 2005, Volume: 27, Issue:5

    Topics: Adaptation, Physiological; Animals; Anxiety; Cell Proliferation; Corticosterone; Dentate Gyrus; Depr

2005
Stressors affect the response of male and female rats to clomipramine in a model of behavioral despair (forced swim test).
    European journal of pharmacology, 2005, Sep-27, Volume: 520, Issue:1-3

    Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Clomipramine; Corticosterone; Depressio

2005
[Effects of total triterpenes of Centella asiatica on the corticosterone levels in serum and contents of monoamine in depression rat brain].
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2005, Volume: 28, Issue:6

    Topics: Animals; Antidepressive Agents; Biogenic Monoamines; Brain; Centella; Corticosterone; Depression; Ma

2005
Beneficial effects of exercise and its molecular mechanisms on depression in rats.
    Behavioural brain research, 2006, Mar-15, Volume: 168, Issue:1

    Topics: Animals; Body Weight; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Exploratory Beh

2006
Effect of different doses of corticosterone on depression-like behavior and HPA axis responses to a novel stressor.
    Behavioural brain research, 2006, Apr-03, Volume: 168, Issue:2

    Topics: Animals; Behavior, Animal; Body Weight; Corticosterone; Depression; Disease Models, Animal; Dose-Res

2006
Corticosterone-induced inhibition of gliogenesis in rat hippocampus is counteracted by electroconvulsive seizures.
    Biological psychiatry, 2006, Jan-15, Volume: 59, Issue:2

    Topics: Animals; Antigens; Cell Count; Cell Differentiation; Cell Proliferation; Corticosterone; Depression;

2006
Antidepressant-like effect of saponins extracted from Chaihu-jia-longgu-muli-tang and its possible mechanism.
    Life sciences, 2006, Jul-17, Volume: 79, Issue:8

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Calcium; Cell Survival; Corticosterone; Depression

2006
Feeding, exploratory, anxiety- and depression-related behaviors are not altered in interleukin-6-deficient male mice.
    Behavioural brain research, 2006, Jul-15, Volume: 171, Issue:1

    Topics: Adrenocorticotropic Hormone; Analysis of Variance; Animals; Anxiety; Biogenic Amines; Brain; Cortico

2006
The comparison of changes in behavior, neurochemistry, endocrine, and immune functions after different routes, doses and durations of administrations of IL-1beta in rats.
    Pharmacopsychiatry, 2006, Volume: 39, Issue:3

    Topics: Animals; Arousal; Behavior, Animal; Brain; Corticosterone; Depression; Dinoprostone; Dopamine; Dose-

2006
Chronobiological disturbances with hyperthermia and hypercortisolism induced by chronic mild stress in rats.
    Behavioural brain research, 2006, Oct-16, Volume: 173, Issue:2

    Topics: Analysis of Variance; Animals; Body Temperature; Chronobiology Disorders; Circadian Rhythm; Corticos

2006
Imipramine and citalopram reverse corticosterone-induced alterations in the effects of the activation of 5-HT(1A) and 5-HT(2) receptors in rat frontal cortex.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2006, Volume: 57, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Antidepressive Agents, Second-Generat

2006
Modeling the anxiety-depression continuum hypothesis in domestic fowl chicks.
    Behavioural pharmacology, 2006, Volume: 17, Issue:8

    Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety; Chickens;

2006
Differential regulation of neurotrophins and serotonergic function in mice with genetically reduced glucocorticoid receptor expression.
    Experimental neurology, 2007, Volume: 204, Issue:1

    Topics: Animals; Biogenic Monoamines; Brain; Brain-Derived Neurotrophic Factor; Circadian Rhythm; Corticoste

2007
Signs of attenuated depression-like behavior in vasopressin deficient Brattleboro rats.
    Hormones and behavior, 2007, Volume: 51, Issue:3

    Topics: Adaptation, Psychological; Adrenocorticotropic Hormone; Animals; Behavior, Animal; Corticosterone; D

2007
Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanisms.
    Life sciences, 2007, Mar-20, Volume: 80, Issue:15

    Topics: Alkaloids; Animals; Antidepressive Agents; Benzodioxoles; Brain-Derived Neurotrophic Factor; Cell Pr

2007
Cognitive impairment associated to HPA axis hyperactivity after maternal separation in rats.
    Psychoneuroendocrinology, 2007, Volume: 32, Issue:3

    Topics: Adaptation, Psychological; Analysis of Variance; Animals; Cognition Disorders; Corticosterone; Corti

2007
Chronic food restriction in young rats results in depression- and anxiety-like behaviors with decreased expression of serotonin reuptake transporter.
    Brain research, 2007, May-30, Volume: 1150

    Topics: Animals; Animals, Newborn; Anxiety; Behavior, Animal; Brain Chemistry; Corticosterone; Depression; D

2007
The role of vasopressin in chronic stress studied in a chronic mild stress model of depression.
    Ideggyogyaszati szemle, 2007, Mar-30, Volume: 60, Issue:3-4

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Body Weight; Chronic Disease; Corticosterone;

2007
Increase of locomotor activity underlying the behavioral disinhibition in tg2576 mice.
    Behavioral neuroscience, 2007, Volume: 121, Issue:2

    Topics: Adrenal Glands; Alzheimer Disease; Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; E

2007
Hypothalamus-pituitary-adrenal modifications consequent to chronic stress exposure in an experimental model of depression in rats.
    Neuroscience, 2007, Jun-08, Volume: 146, Issue:4

    Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Corticosterone; Corticotropin-Releasing

2007
Repeated exposure to stress across the childhood-adolescent period alters rats' anxiety- and depression-like behaviors in adulthood: The importance of stressor type and gender.
    Behavioral neuroscience, 2007, Volume: 121, Issue:3

    Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Anxiety; Behavior, Animal; Body Weight

2007
Intranasal immune challenge induces sex-dependent depressive-like behavior and cytokine expression in the brain.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2008, Volume: 33, Issue:5

    Topics: Administration, Intranasal; Analysis of Variance; Animals; Behavior, Animal; Brain; Corticosterone;

2008
Involvement of the hypothalamic-pituitary-adrenal axis in the antidepressant-like effects of mild hypoxic preconditioning in rats.
    Psychoneuroendocrinology, 2007, Volume: 32, Issue:7

    Topics: Animals; Corticosterone; Depression; Electroshock; Helplessness, Learned; Hypothalamo-Hypophyseal Sy

2007
Effects of chronic and acute stressors and CRF on depression-like behavior in mice.
    Behavioural brain research, 2008, Jan-10, Volume: 186, Issue:1

    Topics: Acute Disease; Adaptation, Psychological; Adrenocorticotropic Hormone; Analysis of Variance; Animals

2008
Repeated social defeat-induced depression-like behavioral and biological alterations in rats: involvement of cholecystokinin.
    Molecular psychiatry, 2008, Volume: 13, Issue:12

    Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Bromodeoxyuridine; Cell Proliferati

2008
Increased water temperature renders single-housed C57BL/6J mice susceptible to antidepressant treatment in the forced swim test.
    Behavioural brain research, 2008, Feb-11, Volume: 187, Issue:1

    Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Corticosterone; Data Interpretatio

2008
Antidepressant-like behavioral effects of impaired cannabinoid receptor type 1 signaling coincide with exaggerated corticosterone secretion in mice.
    Psychoneuroendocrinology, 2008, Volume: 33, Issue:1

    Topics: Adaptation, Psychological; Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Corticos

2008
An anti-immobility effect of exogenous corticosterone in mice.
    European journal of pharmacology, 2008, Feb-02, Volume: 580, Issue:1-2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Desipramine; Disease M

2008
Chronic corticosterone injections induce a decrease of ATP levels and sustained activation of AMP-activated protein kinase in hippocampal tissues of male mice.
    Brain research, 2008, Jan-29, Volume: 1191

    Topics: Adenosine Triphosphate; Adenylate Kinase; AMP-Activated Protein Kinases; Animals; Corticosterone; De

2008
Bacterial infection early in life protects against stressor-induced depressive-like symptoms in adult rats.
    Psychoneuroendocrinology, 2008, Volume: 33, Issue:3

    Topics: Animals; Animals, Newborn; Bacterial Infections; Behavior, Animal; Corticosterone; Depression; Elect

2008
Antidepressant-like effect of onion (Allium cepa L.) powder in a rat behavioral model of depression.
    Bioscience, biotechnology, and biochemistry, 2008, Volume: 72, Issue:1

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal

2008
A mouse model of depression induced by repeated corticosterone injections.
    European journal of pharmacology, 2008, Feb-26, Volume: 581, Issue:1-2

    Topics: Animals; Body Weight; Corticosterone; Depression; Disease Models, Animal; Hindlimb Suspension; Hippo

2008
Reduced anxiety-like and depression-related behavior in neuropeptide Y Y4 receptor knockout mice.
    Genes, brain, and behavior, 2008, Volume: 7, Issue:5

    Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Exploratory Behavior; Female; Fever;

2008
Chronic low dose corticosterone exposure decreased hippocampal cell proliferation, volume and induced anxiety and depression like behaviours in mice.
    European journal of pharmacology, 2008, Mar-31, Volume: 583, Issue:1

    Topics: Adrenal Glands; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic;

2008
The immobility produced by intermittent swim stress is not mediated by serotonin.
    Pharmacology, biochemistry, and behavior, 2008, Volume: 89, Issue:3

    Topics: Animals; Body Temperature; Corticosterone; Depression; Fenclonine; Immobilization; Male; Rats; Rats,

2008
Evaluation of effects of previous exposure to an acute stressor before testing for depression-like behaviours in mice.
    Stress (Amsterdam, Netherlands), 2008, Volume: 11, Issue:2

    Topics: Animals; Avoidance Learning; Behavior, Animal; Corticosterone; Depression; Electroshock; Helplessnes

2008
Tiagabine treatment is associated with neurochemical, immune and behavioural alterations in the olfactory bulbectomized rat model of depression.
    Pharmacopsychiatry, 2008, Volume: 41, Issue:2

    Topics: Animals; Behavior, Animal; Brain Chemistry; Corticosterone; Depression; GABA Agonists; Immunity, Cel

2008
Maternal separation of rat pups increases the risk of developing depressive-like behavior after subsequent chronic stress by altering corticosterone and neurotrophin levels in the hippocampus.
    Neuroscience research, 2008, Volume: 61, Issue:1

    Topics: Animals; Antioxidants; Anxiety, Separation; Behavior, Animal; Chronic Disease; Corticosterone; Corti

2008
Increased depressive behaviour in females and heightened corticosterone release in males to swim stress after adolescent social stress in rats.
    Behavioural brain research, 2008, Jun-26, Volume: 190, Issue:1

    Topics: Analysis of Variance; Animals; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal;

2008
Disruption of the circadian output molecule prokineticin 2 results in anxiolytic and antidepressant-like effects in mice.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009, Volume: 34, Issue:2

    Topics: Animals; Anxiety; Arousal; Body Temperature; Circadian Rhythm; Corticosterone; Depression; Eating; G

2009
Effect of some antidepressants on the low corticosterone concentration-induced gene transcription in LMCAT fibroblast cells.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2008, Volume: 59, Issue:1

    Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Cell Line, Tumor; Corticosterone;

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
    Journal of psychiatric research, 2008, Volume: 43, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom

2008
Influence of continuous infusion of interleukin-1beta on depression-related processes in mice: corticosterone, circulating cytokines, brain monoamines, and cytokine mRNA expression.
    Psychopharmacology, 2008, Volume: 199, Issue:2

    Topics: Animals; Annexin A2; Biogenic Monoamines; Brain Chemistry; Corticosterone; Cytokines; Depression; En

2008
The neuropharmacological effects of electroconvulsive shock and their relationship to the therapeutic effect of electroconvulsive therapy in depression.
    Advances in biochemical psychopharmacology, 1984, Volume: 39

    Topics: Anesthesia, General; Animals; Antidepressive Agents; Apomorphine; Behavior, Animal; Brain; Corticost

1984
Hippocampal kindling: corticosterone modulation of induced seizures.
    Brain research, 1984, Sep-10, Volume: 309, Issue:2

    Topics: Adrenalectomy; Animals; Corticosterone; Depression; Electroencephalography; Hippocampus; Humans; Kin

1984
Effects of zometapine, a structurally novel antidepressant, in an animal model of depression.
    Pharmacology, biochemistry, and behavior, 1984, Volume: 21, Issue:4

    Topics: Animals; Antidepressive Agents; Azepines; Corticosterone; Defecation; Depression; Disease Models, An

1984
The effect of acute and chronic administration of desmethylimipramine on responses to stress in rats.
    Progress in neuro-psychopharmacology & biological psychiatry, 1984, Volume: 8, Issue:4-6

    Topics: Acute Disease; Animals; Anorexia; Chronic Disease; Corticosterone; Depression; Desipramine; Electros

1984
Hippocampal glucocorticoid binding: serotoninergic regulation and drug effects; relevance to behavioral-endocrine activities and depression.
    Annali dell'Istituto superiore di sanita, 1982, Volume: 18, Issue:1

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Hippocampus; Humans; M

1982
Acute and chronic stress effects on open field activity in the rat: implications for a model of depression.
    Neuroscience and biobehavioral reviews, 1981,Summer, Volume: 5, Issue:2

    Topics: Acute Disease; Animals; Chronic Disease; Corticosterone; Depression; Disease Models, Animal; Humans;

1981
Further studies on a novel animal model of depression: therapeutic effects of a tricyclic antidepressant.
    Neuroscience and biobehavioral reviews, 1981,Summer, Volume: 5, Issue:2

    Topics: Acute Disease; Animals; Chronic Disease; Corticosterone; Defecation; Depression; Disease Models, Ani

1981
Amphetamine and tranylcypromine in an animal model of depression: pharmacological specificity of the reversal effect.
    Neuroscience and biobehavioral reviews, 1981,Summer, Volume: 5, Issue:2

    Topics: Amphetamine; Animals; Chronic Disease; Corticosterone; Defecation; Depression; Disease Models, Anima

1981
Animal model of depression: effects of electroconvulsive shock therapy.
    Neuroscience and biobehavioral reviews, 1981,Summer, Volume: 5, Issue:2

    Topics: Animals; Corticosterone; Defecation; Depression; Disease Models, Animal; Electroconvulsive Therapy;

1981
Amitriptyline and scopolamine in an animal model of depression.
    Neuroscience and biobehavioral reviews, 1981,Summer, Volume: 5, Issue:2

    Topics: Amitriptyline; Animals; Antidepressive Agents; Corticosterone; Defecation; Depression; Disease Model

1981
Preclinical pharmacology of FG5893: a potential anxiolytic drug with high affinity for both 5-HT1A and 5-HT2A receptors.
    European journal of pharmacology, 1994, Aug-22, Volume: 261, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Avoidance Learning; Behavior,

1994
Platelet 5-hydroxytryptamine (5-HT) transporter and 5-HT2A receptor binding after chronic hypercorticosteronemia, (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane administration or neurotoxin-induced depletion of central nervous system 5-HT in the rat.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 278, Issue:3

    Topics: Amphetamines; Animals; Blood Platelets; Brain; Brain Mapping; Carrier Proteins; Citalopram; Corticos

1996
Dehydroepiandrosterone decreases behavioral despair in high- but not low-anxiety rats.
    Physiology & behavior, 1997, Volume: 62, Issue:5

    Topics: Animals; Anxiety; Arousal; Corticosterone; Dehydroepiandrosterone; Depression; Fear; Helplessness, L

1997
Decreased 5-HT1A and increased 5-HT2A receptor binding after chronic corticosterone associated with a behavioural indication of depression but not anxiety.
    Psychoneuroendocrinology, 1997, Volume: 22, Issue:7

    Topics: Animals; Anti-Inflammatory Agents; Anxiety; Autoradiography; Behavior, Animal; Body Weight; Corticos

1997
Forced swim test-induced neurochemical endocrine, and immune changes in the rat.
    Pharmacology, biochemistry, and behavior, 1997, Volume: 58, Issue:4

    Topics: Animals; Biogenic Monoamines; Brain Chemistry; Corticosterone; Depression; Endocrine Glands; Hypotha

1997
Forced swim test-induced endocrine and immune changes in the rat: effect of subacute desipramine treatment.
    Pharmacology, biochemistry, and behavior, 1998, Volume: 59, Issue:1

    Topics: Adrenal Glands; Animals; Antidepressive Agents, Tricyclic; Ascorbic Acid; Corticosterone; Depression

1998
A.E. Bennett Research Award. Regulation of serotonin1A, glucocorticoid, and mineralocorticoid receptor in rat and human hippocampus: implications for the neurobiology of depression.
    Biological psychiatry, 1998, Apr-15, Volume: 43, Issue:8

    Topics: Adrenalectomy; Animals; Antidepressive Agents; Autoradiography; Corticosterone; Depression; Hippocam

1998
Differential effects of prenatal stress in two inbred strains of rats.
    Pharmacology, biochemistry, and behavior, 1998, Volume: 59, Issue:4

    Topics: Animals; Avoidance Learning; Body Weight; Corticosterone; Depression; Female; Hot Temperature; Male;

1998
Effects of bilateral olfactory bulbectomy on circadian rhythms of ACTH, corticosterone, motor activity and body temperature in male rats.
    Archives of physiology and biochemistry, 1997, Volume: 105, Issue:6

    Topics: Adrenocorticotropic Hormone; Animals; Body Temperature Regulation; Circadian Rhythm; Corticosterone;

1997
Chronic cholestasis in rats induces anhedonia and a loss of social interest.
    Hepatology (Baltimore, Md.), 1998, Volume: 28, Issue:1

    Topics: Animals; Behavior, Animal; Cholestasis; Chronic Disease; Corticosterone; Depression; Dexamethasone;

1998
[Putative contribution of the epiphyseal-adrenocortical system in the antidepressive effect of imipramine].
    Biulleten' eksperimental'noi biologii i meditsiny, 1998, Volume: 125, Issue:6

    Topics: Adrenal Cortex; Animals; Antidepressive Agents, Tricyclic; Corticosterone; Depression; Drug Interact

1998
The effect of repeated exposure to forced swimming on extracellular levels of 5-hydroxytryptamine in the rat.
    Stress (Amsterdam, Netherlands), 1998, Volume: 2, Issue:4

    Topics: Animals; Behavior, Animal; Corpus Striatum; Corticosterone; Depression; Disease Models, Animal; Extr

1998
Genetic alteration of the alpha2-adrenoceptor subtype c in mice affects the development of behavioral despair and stress-induced increases in plasma corticosterone levels.
    Molecular psychiatry, 1999, Volume: 4, Issue:5

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Cerebral Cortex; Corpus Striatum; Cortico

1999
Alpha-1-noradrenergic neurotransmission, corticosterone, and behavioral depression.
    Biological psychiatry, 1999, Nov-01, Volume: 46, Issue:9

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Anti-Inflammatory Agents; Behavi

1999
Olfactory bulbectomy provokes a suppression of interleukin-1beta and tumour necrosis factor-alpha production in response to an in vivo challenge with lipopolysaccharide: effect of chronic desipramine treatment.
    Neuroimmunomodulation, 2000, Volume: 7, Issue:1

    Topics: Adrenal Cortex; Animals; Antidepressive Agents, Tricyclic; Ascorbic Acid; Behavior, Animal; Corticos

2000
Inhibition of 11beta-hydroxysteroid dehydrogenase, the foeto-placental barrier to maternal glucocorticoids, permanently programs amygdala GR mRNA expression and anxiety-like behaviour in the offspring.
    The European journal of neuroscience, 2000, Volume: 12, Issue:3

    Topics: 11-beta-Hydroxysteroid Dehydrogenases; Amygdala; Animals; Anxiety; Behavior, Animal; Brain Chemistry

2000
Dehydroepiandrosterone sulfate (DHEAS) counteracts decremental effects of corticosterone on dentate gyrus LTP. Implications for depression.
    Brain research bulletin, 2000, Volume: 52, Issue:3

    Topics: Action Potentials; Animals; Anti-Inflammatory Agents; Corticosterone; Dehydroepiandrosterone Sulfate

2000
[High performance liquid chromatography of corticosteroids in patients with depression and depersonalization].
    Klinicheskaia laboratornaia diagnostika, 2000, Issue:4

    Topics: Adult; Chromatography, High Pressure Liquid; Corticosterone; Cortisone; Depersonalization; Depressio

2000
Decreased body temperature dependent appearance of behavioral despair in the forced swimming test in mice.
    Pharmacological research, 2000, Volume: 42, Issue:2

    Topics: Animals; Behavior, Animal; Blood Glucose; Body Temperature; Brain; Carbon Radioisotopes; Cold Temper

2000
The novel 5-Hydroxytryptamine(1A) antagonist LY426965: effects on nicotine withdrawal and interactions with fluoxetine.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 294, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acoustic Stimulation; Animals; Body Temperature; Columbidae;

2000
Hypertension and insulin resistant models have divergent propensities to learned helpless behavior in rodents.
    American journal of hypertension, 2000, Volume: 13, Issue:6 Pt 1

    Topics: Animals; Behavior, Animal; Biomarkers; Blood Pressure; Comorbidity; Corticosterone; Depression; Fema

2000
Corticotropin-releasing hormone mRNA levels in response to chronic mild stress rise in male but not in female rats while tyrosine hydroxylase mRNA levels decrease in both sexes.
    Psychoneuroendocrinology, 2001, Volume: 26, Issue:1

    Topics: Adrenal Cortex; Animals; Corticosterone; Corticotropin-Releasing Hormone; Depression; Female; Gene E

2001
Neuroendocrine and behavioral effects of repetitive transcranial magnetic stimulation in a psychopathological animal model are suggestive of antidepressant-like effects.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2001, Volume: 24, Issue:4

    Topics: Adaptation, Psychological; Adrenocorticotropic Hormone; Animals; Anxiety; Behavior, Animal; Computer

2001
Altered hormone levels and circadian rhythm of activity in the WKY rat, a putative animal model of depression.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2001, Volume: 281, Issue:3

    Topics: Activity Cycles; Adrenocorticotropic Hormone; Animals; Behavior, Animal; Chronobiology Disorders; Co

2001
Sex differences in the effects of neonatal handling on the animal's response to stress and the vulnerability for depressive behaviour.
    Behavioural brain research, 2002, Feb-01, Volume: 129, Issue:1-2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Animals, Newborn; Corticosterone; Depression; Femal

2002
Amplified behavioral and endocrine responses to forced swim stress in the Wistar-Kyoto rat.
    Psychoneuroendocrinology, 2002, Volume: 27, Issue:3

    Topics: Adrenocorticotropic Hormone; Animals; Arousal; Corticosterone; Depression; Dexamethasone; Feedback;

2002
Anxiogenic and depressive-like effects, but no cognitive deficits, after repeated moderate tryptophan depletion in the rat.
    Journal of psychopharmacology (Oxford, England), 2002, Volume: 16, Issue:1

    Topics: Animals; Anxiety; Attention; Body Weight; Cerebral Cortex; Cognition; Corticosterone; Depression; Fo

2002
Clinical implications of state-dependent learning.
    The American journal of psychiatry, 1979, Volume: 136, Issue:7

    Topics: Animals; Arousal; Association Learning; Bipolar Disorder; Circadian Rhythm; Corticosterone; Cues; De

1979
Alterations in the hypothalamic-pituitary-adrenal axis in a proposed animal model of depression with genetic muscarinic supersensitivity.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1991, Volume: 4, Issue:2

    Topics: Adrenocorticotropic Hormone; Animals; Brain Chemistry; Corticosterone; Corticotropin-Releasing Hormo

1991
Effects of bilateral adrenalectomy on the induction of learned helplessness behavior.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1990, Volume: 3, Issue:2

    Topics: Adrenalectomy; Animals; Corticosterone; Depression; Disease Models, Animal; Electroshock; Escape Rea

1990
5-Hydroxytryptamine and corticosterone in an animal model of depression.
    Progress in neuro-psychopharmacology & biological psychiatry, 1989, Volume: 13, Issue:3-4

    Topics: Animals; Corticosterone; Depression; Disease Models, Animal; Rats; Restraint, Physical; Serotonin; S

1989
Endocrine function in emotionally disturbed and normal men.
    The Journal of nervous and mental disease, 1968, Volume: 146, Issue:6

    Topics: 17-Ketosteroids; Adjustment Disorders; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult;

1968
Contraceptives, brain serotonin, and liver tryptophan pyrrolase.
    Lancet (London, England), 1970, Jul-25, Volume: 2, Issue:7665

    Topics: Animals; Brain; Contraceptives, Oral; Corticosterone; Depression; Female; Humans; Hydroxyindoleaceti

1970
Neuropsychiatric problems in systemic lupus erythematosus.
    British medical journal, 1972, Nov-11, Volume: 4, Issue:5836

    Topics: Adolescent; Adult; Cognition Disorders; Corticosterone; Cranial Nerves; Depression; Epilepsy; Female

1972
Estimation of corticosteroids in human cerebral cortex after death by suicide, accident, or disease.
    Psychological medicine, 1972, Volume: 2, Issue:1

    Topics: 17-Hydroxycorticosteroids; Accidents; Adult; Aged; Autopsy; Brain Chemistry; Cerebral Cortex; Chroma

1972
Effects of adrenal hormones and stress on brain serotonin.
    The American journal of clinical nutrition, 1971, Volume: 24, Issue:7

    Topics: Adrenal Cortex Hormones; Allopurinol; Animals; Brain; Corticosterone; Depression; Depression, Chemic

1971