corticosterone has been researched along with Depression in 863 studies
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
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" In this study we have evaluated the MMP-9 activity and protein expression in brain areas relevant to depression using the chronic corticosterone mouse model of depression." | 8.31 | Brain matrix metalloproteinase-9 activity is altered in the corticosterone mouse model of depression. ( Breviario, S; Castro, E; Díaz, Á; Florensa-Zanuy, E; Garro-Martínez, E; Pazos, Á; Pilar-Cuéllar, F; Senserrich, J, 2023) |
"Here, we employed mouse models of depression induced by chronic unpredictable stress exposure or corticosterone (CORT) stimulation." | 8.31 | MAD2B Blunts Chronic Unpredictable Stress and Corticosterone Stimulation-Induced Depression-Like Behaviors in Mice. ( Meng, X; Miao, C; Su, Y; Wang, XL; Zhang, C, 2023) |
" Pups whose dams consumed the HFS diet during gestation and lactation exhibited increased depression-related behavior and baseline serum corticosterone levels, but no difference in peak levels in response to stress." | 8.31 | Comparison of maternal versus postweaning ingestion of a high fat, high sucrose diet on depression-related behavior, novelty reactivity, and corticosterone levels in young, adult rat offspring. ( Farber, C; Koh, GY; Lane, MA; McKenzie, A; Muraida, JD; Renteria, K; Ritter, J; Rivers, C; Zhu, J, 2023) |
"Mirtazapine (MIRT) is a multi-target antidepressant used in treatment of severe depression with promising efficacy, but also with important side effects, mainly sedation and weight gain." | 8.12 | Lipoic acid prevents mirtazapine-induced weight gain in mice without impairs its antidepressant-like action in a neuroendocrine model of depression. ( Chaves Filho, AJM; Cunha, NL; De Oliveira, GMF; Gadelha Filho, CVJ; Jucá, PM; Macedo, DS; Oliveira, TQ; Soares, MVR; Vasconcelos, SMM; Viana, GA; Vieira, CFX, 2022) |
"Selective serotonergic reuptake inhibitors, including fluoxetine (FLX), are the most commonly used for the treatment of major depression." | 8.12 | Galanin (1-15) Enhances the Behavioral Effects of Fluoxetine in the Olfactory Bulbectomy Rat, Suggesting a New Augmentation Strategy in Depression. ( Cantero-García, N; Díaz-Cabiale, Z; Flores-Burgess, A; Fuxe, K; Gago, B; García-Durán, L; Millón, C; Narváez, JA; Puigcerver, A; Santín, L, 2022) |
" Changes of serotonin (5-HT), dopamine (DA), norepinephrine (NE), serum corticosterone (CORT), adrenocorticotropic hormone (ACTH), organ index, and histopathology in brain tissue, to explore the treatment and characteristics of total white glucosides in depression model, were prepared by different stimuli in 21 days." | 8.12 | Pharmacological Study on Total Glycosides of Xiebai Protecting against Depression Model. ( Jiang, M; Miao, M; Zhao, H, 2022) |
"The aim of this study was to investigate the antidepressant effect of Jujuboside A (JuA) on corticosterone (CORT)-induced depression in mice and explore the underlying mechanisms." | 8.12 | Antidepressant effect of Jujuboside A on corticosterone-induced depression in mice. ( Gong, J; Li, H; Li, J; Xie, X; Zhang, T, 2022) |
"Sustained elevation of corticosterone (CORT) is one of the common causes of aging and major depression disorder." | 8.02 | Low corticosterone levels attenuate late life depression and enhance glutamatergic neurotransmission in female rats. ( Chen, NH; Chu, SF; Cui, LY; He, HY; He, WB; Wang, ZZ; Yang, B; Zhang, Z; Zhou, X, 2021) |
" Thus, the effects of naringenin, a potent antioxidant, anti-inflammatory and neuroprotective bioflavonoid on hypoxic stress-induced depressive-like and anxiety-related behaviors in mice, and the underlying molecular mechanisms were evaluated in this study." | 8.02 | Naringenin improves depressive- and anxiety-like behaviors in mice exposed to repeated hypoxic stress through modulation of oxido-inflammatory mediators and NF-kB/BDNF expressions. ( Ajayi, AM; Bakre, AG; Ben-Azu, B; Femi-Akinlosotu, O; Olugbemide, AS; Umukoro, S, 2021) |
"Metformin attenuated the depression-like behaviors induced by CORT." | 8.02 | Metformin Attenuates the Metabolic Disturbance and Depression-like Behaviors Induced by Corticosterone and Mediates the Glucose Metabolism Pathway. ( Guan, Y; Guo, Y; Hao, Y; Huang, X; Lang, X; Li, Z; Tong, Y; Xie, X, 2021) |
" The treatments with ketamine, guanosine, and ketamine plus guanosine were effective to counteract corticosterone-induced anxiety-like phenotype, but not disturbances in the hippocampal NLRP3 pathway." | 8.02 | Low doses of ketamine and guanosine abrogate corticosterone-induced anxiety-related behavior, but not disturbances in the hippocampal NLRP3 inflammasome pathway. ( Camargo, A; Dalmagro, AP; Fraga, DB; Kaster, MP; Rodrigues, ALS; Rosa, JM; Zeni, ALB, 2021) |
"The present study aimed to evaluate the potential role of ANXA1 and its main receptor, as a cellular mediator of behavioural disorders, in a model of Corticosterone (CORT)-induced depression and subsequently, the possible correlation between the depressive state and impairment of hippocampal memory." | 7.96 | The Role of Annexin A1 and Formyl Peptide Receptor 2/3 Signaling in Chronic Corticosterone-Induced Depression-Like behaviors and Impairment in Hippocampal-Dependent Memory. ( Cordaro, M; Crupi, R; Cuzzocrea, S; D'amico, R; Di Paola, R; Fusco, R; Gugliandolo, E; Impellizzeri, D; Peritore, AF; Scuto, M; Siracusa, R, 2020) |
" Here we aimed to compare the effects of (R)-norketamine ((R)-NK), (S)-NK, (2R,6R)-HNK, and (2S,6S)-HNK in a mouse model of depression induced by chronic corticosterone (CORT) injection." | 7.96 | (S)-norketamine and (2S,6S)-hydroxynorketamine exert potent antidepressant-like effects in a chronic corticosterone-induced mouse model of depression. ( Ago, Y; Chen, L; Hashimoto, H; Hashimoto, K; Higuchi, M; Kasai, A; Naito, M; Nakagawa, S; Nakazawa, T; Seiriki, K; Tanabe, W; Tsukada, S; Yamaguchi, T; Yokoyama, R, 2020) |
"As a continuation of our previous experiments, this study aimed to investigate the antidepressant- and anxiolytic-like activity of pitolisant in mice using the corticosterone-induced depression model." | 7.96 | Pitolisant protects mice chronically treated with corticosterone from some behavioral but not metabolic changes in corticosterone-induced depression model. ( Kieć-Kononowicz, K; Kotańska, M; Mika, K; Pytka, K; Sapa, J; Sałaciak, K; Wheeler, L, 2020) |
" Considering that ketamine has significant knock-on effects, this study investigated the effects of a single coadministration with subthreshold doses of ketamine plus guanosine in a corticosterone (CORT)-induced animal model of depression and the role of anti-inflammatory and antioxidant pathways." | 7.96 | Subthreshold doses of guanosine plus ketamine elicit antidepressant-like effect in a mouse model of depression induced by corticosterone: Role of GR/NF-κB/IDO-1 signaling. ( B Zeni, AL; Camargo, A; Dalmagro, AP; M Rosa, J; P Kaster, M; S Rodrigues, AL; Tasca, CI, 2020) |
"This study assessed the effect of swimming training on anxiety-like behaviors and corticosterone." | 7.96 | The Effect of Swimming on Anxiety-Like Behaviors and Corticosterone in Stressed and Unstressed Rats. ( Aligholi, H; Brand, S; Koushkie Jahromi, M; Rezaei, R; Safari, MA, 2020) |
"A total of 36 rats were randomly assigned to three groups: a normal group, model group (depression), and treatment group (depression + gentiopicroside)." | 7.91 | Metabolomic evidence for the therapeutic effect of gentiopicroside in a corticosterone-induced model of depression. ( Cui, Q; Liu, Z; Wang, C; Wang, G; Yao, T; Zhang, Q, 2019) |
"To discover and assess the differentially expressed proteins (DEPs) of hippocampus after oral administration of XCHT in corticosterone (CORT) induced model of depression by using isobaric tags for relative and absolute quantification (iTRAQ) analysis." | 7.91 | Quantitative proteomics reveal antidepressant potential protein targets of xiaochaihutang in corticosterone induced model of depression. ( He, M; Li, Y; Pan, X; Su, D; Wu, C; Yang, J; Zhang, H; Zhang, K, 2019) |
" A treatment with escitalopram reversed depression-like behavior accompanied by reductions in BDNF levels in serum and the nucleus accumbens, while a treatment with blonanserin ameliorated abnormal social interaction behavior with reductions in serum BDNF levels." | 7.91 | Antidepressant activities of escitalopram and blonanserin on prenatal and adolescent combined stress-induced depression model: Possible role of neurotrophic mechanism change in serum and nucleus accumbens. ( Deriha, K; Furuse, K; Hashiguchi, H; Hashimoto, E; Ishii, T; Kawanishi, C; Kigawa, Y; Shiraishi, M; Tayama, M; Ukai, W, 2019) |
" This study utilized a translational animal model of maternal depression (based on giving high levels of corticosterone (CORT, 40 mg/kg, s." | 7.91 | Developmental outcomes after gestational antidepressant treatment with sertraline and its discontinuation in an animal model of maternal depression. ( Brummelte, S; Kott, JM; Mooney-Leber, SM, 2019) |
"Our previous finding demonstrated that chronic corticosterone (CORT) may be involved in mediating the pathophysiology of premature aging in rats." | 7.91 | Exposure to jet lag aggravates depression-like behaviors and age-related phenotypes in rats subject to chronic corticosterone. ( Fu, Z; Ni, Y; Shen, Q; Wang, X; Wu, J; Xiao, Q; Xie, X; Yu, C; Zhou, J, 2019) |
" In this study, we examined the molecular effects associated with a response to a week-long treatment with escitalopram in the chronic escape deficit (CED) model, a validated model of depression based on the induction of an escape deficit after exposure of rats to an unavoidable stress." | 7.88 | Molecular changes associated with escitalopram response in a stress-based model of depression. ( Alboni, S; Benatti, C; Blom, JMC; Brunello, N; Mendlewicz, J; Tascedda, F, 2018) |
"Many models, such as chronic mild stress, chronic stress or chronic corticosterone injections are used to induce depression associated with cognitive deficits." | 7.88 | Combined corticosterone treatment and chronic restraint stress lead to depression associated with early cognitive deficits in mice. ( Bahane, DAN; Bum, EN; Ngoupaye, GT; Yassi, FB, 2018) |
" Magnolol, main constituent identified in the barks of Magnolia officinalis, exerted antidepressant effects in a rat model of depression induced by chronic unpredictable mild stress in previous studies." | 7.88 | Antidepressant effects of magnolol in a mouse model of depression induced by chronic corticosterone injection. ( Bai, Y; Dai, G; Jing, W; Ju, W; Song, L; Xu, M; Zhang, W; Zhu, L, 2018) |
" Therefore, we tested this hypothesis in the depression model of chronic administration of corticosterone (CORT) in mice and treated the animals daily with liraglutide (5 or 20 nmol/kg ip." | 7.88 | Liraglutide attenuates the depressive- and anxiety-like behaviour in the corticosterone induced depression model via improving hippocampal neural plasticity. ( Birong, L; Christian, H; Feiyu, S; Le, W; Weina, H; Yuhu, N, 2018) |
" The corticosterone rat model was developed to understand the influence of stress on depression-like symptomatology." | 7.88 | Depression-like behaviors induced by chronic corticosterone exposure via drinking water: Time-course analysis. ( Cui, SY; Cui, XY; Ding, H; Hu, X; Liu, YT; Ye, H; Zhang, YH; Zhao, HL, 2018) |
"To further explore the underlying antidepressant mechanism of ginseng total saponins (GTS), this study observed the effects on hippocampal astrocyte structural plasticity and hippocampal volume in the corticosterone-induced mouse depression model." | 7.85 | Preventive Effects of Ginseng Total Saponins on Chronic Corticosterone-Induced Impairment in Astrocyte Structural Plasticity and Hippocampal Atrophy. ( Chen, L; Dai, JG; Huang, YF; Lin, ZX; Wang, X; Zhao, YN, 2017) |
"Corticosterone (CORT) treatment has been evidenced to develop a depression-like state in animals, that mimic hypothalamic-pituitary-adrenal (HPA)-axis dysregulation implicated in the development of depression." | 7.85 | Ferulic acid reverses depression-like behavior and oxidative stress induced by chronic corticosterone treatment in mice. ( Camargo, A; Dalmagro, AP; Zeni, ALB, 2017) |
"Previously published reports have revealed the antidepressant-like effects of icariin in a chronic mild stress model of depression and in a social defeat stress model in mice." | 7.83 | Icariin reverses corticosterone-induced depression-like behavior, decrease in hippocampal brain-derived neurotrophic factor (BDNF) and metabolic network disturbances revealed by NMR-based metabonomics in rats. ( Gong, MJ; Han, B; Liang, SW; Wang, SM; Zou, ZJ, 2016) |
" Since the BDNF hypothesis of depression postulates that a reduction in BDNF is directly involved in the pathophysiology of depression, we evaluated the anti-depressive effects of HMF in mice with subcutaneously administered corticosterone at a dose of 20 mg/kg/day for 25 days." | 7.83 | 3,5,6,7,8,3',4'-Heptamethoxyflavone, a Citrus Flavonoid, Ameliorates Corticosterone-Induced Depression-like Behavior and Restores Brain-Derived Neurotrophic Factor Expression, Neurogenesis, and Neuroplasticity in the Hippocampus. ( Amakura, Y; Furukawa, Y; Nakajima, M; Okuyama, S; Sawamoto, A; Yamamoto, K; Yoshimura, M, 2016) |
"In order to relieve anxiety and depression accompanying stress, physicians resort to tricyclic antidepressants, such as imipramine." | 7.83 | Antidepressant imipramine diminishes stress-induced inflammation in the periphery and central nervous system and related anxiety- and depressive- like behaviors. ( Ramirez, K; Sheridan, JF, 2016) |
" In this study, we used the chronic corticosterone (CORT)-induced mouse model of anxiety/depression to assess antidepressant-like effects of baicalin and illuminate possible molecular mechanisms by which baicalin affects GR-mediated hippocampal neurogenesis." | 7.83 | Baicalin promotes hippocampal neurogenesis via SGK1- and FKBP5-mediated glucocorticoid receptor phosphorylation in a neuroendocrine mouse model of anxiety/depression. ( Dong, Y; Ma, J; Pan, X; Su, G; Wang, F; Wu, C; Yang, J; Zhang, K, 2016) |
"The aim of the present study was to investigate the effects of the selective agonists of the corticotropin-releasing factor (CRF) 2 receptor, urocortin 2 (UCN 2) and urocortin 3 (UCN 3), on the anxiety- and depression-like signs induced by acute nicotine withdrawal in mice." | 7.83 | Selective CRF2 receptor agonists ameliorate the anxiety- and depression-like state developed during chronic nicotine treatment and consequent acute withdrawal in mice. ( Bagosi, Z; Balangó, B; Bokor, P; Buzás, A; Csabafi, K; Jászberényi, M; Palotai, M; Pintér, D; Simon, B; Szabó, G, 2016) |
" We found that chronic treatment of a mouse model of anxiety/depression (CORT model) with a selective serotonin reuptake inhibitor (SSRI, fluoxetine, 18mg/kg/day) reversed CORT-induced anxiety/depression-like behavior in mice." | 7.81 | Nrf2-signaling and BDNF: A new target for the antidepressant-like activity of chronic fluoxetine treatment in a mouse model of anxiety/depression. ( Ali, ZE; Damiens, MH; David, DJ; Gardier, AM; Kerdine-Römer, S; Mendez-David, I; Pallardy, M; Tritschler, L, 2015) |
"A mouse model of depression has been recently developed by exogenous corticosterone (CORT) administration, which has shown to mimic HPA-axis induced depression-like state in animals." | 7.81 | Resveratrol ameliorates depressive-like behavior in repeated corticosterone-induced depression in mice. ( Ali, SH; Bodduluru, LN; K V, A; Kasala, ER; Lahkar, M; Madhana, RM; Mahareddy, JR; Pitta, S, 2015) |
" We compared the effects of chronic treatment with the preferential nNOS inhibitor 7-nitroindazole (7-NI) with those evoked by the conventional antidepressant fluoxetine on alterations that are considered as markers of depression (immobility in the forced swimming test, FST, decreased body weight gain and increased plasma corticosterone concentration) and cardiovascular changes caused by CVS." | 7.81 | Effects of nitric oxide synthesis inhibitor or fluoxetine treatment on depression-like state and cardiovascular changes induced by chronic variable stress in rats. ( Almeida, J; Crestani, CC; Duarte, JO; Oliveira, LA, 2015) |
"Repeated injection of corticosterone (CORT) induces dysregulation in the hypothalamic-pituitary-adrenal (HPA) axis, resulting in depression." | 7.81 | Angelica gigas ameliorate depression-like symptoms in rats following chronic corticosterone injection. ( Hahm, DH; Lee, B; Lee, H; Shim, I; Sur, B, 2015) |
" At 12 months, but not earlier, DEX-exposed mice displayed depression-like behavior and impaired hippocampal neurogenesis, not reversible by the antidepressant fluoxetine (FLX)." | 7.81 | Alterations in circadian entrainment precede the onset of depression-like behavior that does not respond to fluoxetine. ( Bose, R; Ceccatelli, S; Conti, M; DuPont, C; Onishchenko, N; Raciti, M; Spulber, S, 2015) |
" This study was carried out in order to assess the influence of neonatal tactile stimulation (TS) on behavioral and morphological responses related to depression-like and anxiety-like behaviors, assessed following the administration of sertraline (SERT), a selective serotonin re-uptake inhibitor (SSRI)." | 7.81 | Neonatal tactile stimulation decreases depression-like and anxiety-like behaviors and potentiates sertraline action in young rats. ( Antoniazzi, CT; Barcelos, RC; Burger, ME; Duarte, MM; Duarte, T; Freitas, D; Metz, VG; Segat, HJ; Vey, LT, 2015) |
"The aim of this study was to examine changes in rat emotional behavior and determine differences in the expression of GABA-A receptor alpha-2 subunits in brain structures of low- (LR) and high-anxiety (HR) rats after the repeated corticosterone administration." | 7.80 | The effect of chronic administration of corticosterone on anxiety- and depression-like behavior and the expression of GABA-A receptor alpha-2 subunits in brain structures of low- and high-anxiety rats. ( Krząścik, P; Lehner, M; Płaźnik, A; Skórzewska, A; Wisłowska-Stanek, A; Ziemba, A, 2014) |
" Herein, we have described a mouse model of a depression-like and insulin-resistant (DIR) state induced by the co-treatment of high-fat diet (HFD) and corticosterone (CORT)." | 7.80 | Depression-like behaviors in mice subjected to co-treatment of high-fat diet and corticosterone are ameliorated by AICAR and exercise. ( Ji, L; Li, H; Liu, W; Zhai, X, 2014) |
"Female rats implanted with 28-day osmotic minipumps delivering the SSRI escitalopram throughout pregnancy had serum escitalopram concentrations in a clinically observed range (17-65 ng/ml)." | 7.79 | Prenatal exposure to escitalopram and/or stress in rats: a prenatal stress model of maternal depression and its treatment. ( Boss-Williams, KA; Bourke, CH; Capello, CF; Owens, MJ; Rogers, SM; Stowe, ZN; Weiss, JM; Yu, ML, 2013) |
"Ablation of olfactory bulbs caused depression-like symptoms as evidenced by increased immobility time in FST, hyperactivity in open field arena, and anhedonic like response in SPT along with alterations in mitochondrial enzyme complexes, increased serum corticosterone levels and oxidative damage." | 7.79 | Suppression of neuroinflammatory and apoptotic signaling cascade by curcumin alone and in combination with piperine in rat model of olfactory bulbectomy induced depression. ( Garg, S; Kumar, A; Rinwa, P, 2013) |
"To observe the effect of hesperidin on behavior and hypothalamic-pituitary-adrenal (HPA) axis of ratmodel of chronic stress-induced depression." | 7.79 | [Effect of hesperidin on behavior and HPA axis of rat model of chronic stress-induced depression]. ( Cai, L; Li, R; Wu, QQ; Wu, TN, 2013) |
"The antidepressant effect of a compound formed by co-ultramicronized palmitoylethanolamide (PEA) and luteolin (PEA+luteolin) was investigated in a mouse model of anxiety/depressive-like behavior." | 7.79 | Effects of palmitoylethanolamide and luteolin in an animal model of anxiety/depression. ( Ahmad, A; Campolo, M; Crupi, R; Cuzzocrea, S; Esposito, E; Paterniti, I, 2013) |
"This study is to investigate the amelioration effect of glucocorticoid receptor (GR) antagonist mifepristone on the changes of learning and memory abilities in rat model of depression." | 7.79 | [Mifepristone repairs alteration of learning and memory abilities in rat model of depression]. ( Chen, NH; Li, J; Liu, Y; Sun, JD; Yuan, YH, 2013) |
" This study examined the effects of mGlu2/3 receptor antagonists in chronic corticosterone-treated mice which could be used as an animal model of depression." | 7.79 | Metabotropic glutamate 2/3 receptor antagonists improve behavioral and prefrontal dopaminergic alterations in the chronic corticosterone-induced depression model in mice. ( Ago, Y; Araki, R; Baba, A; Chaki, S; Hashimoto, H; Hiramatsu, N; Kawasaki, T; Kita, Y; Matsuda, T; Nakazato, A; Onoe, H; Takuma, K; Yano, K, 2013) |
" This study was designed to investigate the effects of Pb(2+)exposure on growth rate, locomotor activity, anxiety, depression, plasma corticosterone and brain serotonin (5-HT) levels in rats." | 7.79 | Alteration in plasma corticosterone levels following long term oral administration of lead produces depression like symptoms in rats. ( Batool, Z; Haider, S; Haleem, DJ; Inam, QU; Khaliq, S; Parveen, T; Saleem, S; Shamim, S; Tabassum, S, 2013) |
" We have developed a mouse model of anxiety/depression based on addition of corticosterone to drinking water." | 7.78 | Functional status of somatodendritic serotonin 1A autoreceptor after long-term treatment with fluoxetine in a mouse model of anxiety/depression based on repeated corticosterone administration. ( David, DJ; Gardier, AM; Guiard, BP; Nguyen, HT; Quesseveur, G; Rainer, Q, 2012) |
"Sub-chronic tryptophan depletion (SCTD) is proposed as an animal model for depression." | 7.78 | Sub-chronic dietary tryptophan depletion--an animal model of depression with improved face and good construct validity. ( Bermudez, I; Franklin, M; Gaburro, S; Murck, H; Singewald, N, 2012) |
"Both chronic mild stress and an injection of corticosterone induce depression-like states in rodents." | 7.78 | Corticosterone reduces brain mitochondrial function and expression of mitofusin, BDNF in depression-like rodents regardless of exercise preconditioning. ( Liu, W; Zhou, C, 2012) |
" In the present study, pain sensitivity was assessed in a mouse model of anxiety/depression on the basis of chronic corticosterone (CORT) administration through the drinking water (CORT model)." | 7.78 | Antinociceptive effects of fluoxetine in a mouse model of anxiety/depression. ( Coudoré, F; David, DJ; Gardier, AM; Guiard, BP; Hache, G; Le Dantec, Y; Orvoën, S, 2012) |
"We examined a potential two-hit murine animal model of depression by assessing whether a genetic deficit in reelin increases vulnerability to the depressogenic effects of the stress hormone corticosterone." | 7.77 | Reelin as a putative vulnerability factor for depression: examining the depressogenic effects of repeated corticosterone in heterozygous reeler mice. ( Caruncho, HJ; Kalynchuk, LE; Lussier, AL; Romay-Tallón, R, 2011) |
"The authors examined whether the spared nerve injury model of neuropathic pain induces depressive behavior in rats, using sucrose preference test and forced swim test, and tested whether a subanesthetic dose of ketamine treats spared nerve injury-induced depression." | 7.77 | A single subanesthetic dose of ketamine relieves depression-like behaviors induced by neuropathic pain in rats. ( Blanck, TJ; Eberle, SE; Goffer, Y; Shamir, DB; Tukey, DS; Wang, J; Xu, D; Ziff, EB; Zou, AH, 2011) |
"We examined the potential of cysteamine, a neuroprotective compound to attenuate anxiety and depression like behaviors in a mouse model of anxiety/depression induced by chronic corticosterone exposure." | 7.77 | Cysteamine attenuates the decreases in TrkB protein levels and the anxiety/depression-like behaviors in mice induced by corticosterone treatment. ( Kutiyanawalla, A; Pillai, A; Terry, AV, 2011) |
"Neonatal treatment with clomipramine (CMI) in rats induces multiple behavioral alterations during adulthood that resemble certain symptoms of human depression, such as impairments of pleasure-seeking behaviors." | 7.76 | Circadian activity of corticosterone in an animal model of depression: response to muscarinic cholinergic stimulation. ( Arteaga-Silva, M; Bonilla-Jaime, H; Hernández-González, M; Retana-Márquez, S; Vázquez-Palacios, G, 2010) |
" Prolonged elevated levels of glucocorticoids are associated with depression and we developed an animal model of postpartum depression/stress based on high levels of corticosterone (CORT) during the postpartum." | 7.76 | Chronic corticosterone during pregnancy and postpartum affects maternal care, cell proliferation and depressive-like behavior in the dam. ( Brummelte, S; Galea, LA, 2010) |
"We have recently shown that repeated high dose injections of corticosterone (CORT) reliably increase depression-like behavior on a modified one-day version of the forced swim test." | 7.75 | Repeated exposure to corticosterone increases depression-like behavior in two different versions of the forced swim test without altering nonspecific locomotor activity or muscle strength. ( Fournier, NM; Kalynchuk, LE; Marks, W, 2009) |
"Repeated injection of corticosterone (CORT) induces dysregulation in the HPA axis, resulting in depression and anxiety." | 7.75 | Effects of acupuncture on chronic corticosterone-induced depression-like behavior and expression of neuropeptide Y in the rats. ( Hahm, DH; Lee, B; Lee, HJ; Shim, I; Yang, Y, 2009) |
" The atypical antipsychotic risperidone and the selective serotonin (5-HT)(2) antagonist ritanserin normalized the depression-like behavior in PACAP-/- mice." | 7.75 | Depression-like behavior in the forced swimming test in PACAP-deficient mice: amelioration by the atypical antipsychotic risperidone. ( Baba, A; Guo, X; Hashimoto, H; Hashimoto, R; Hatanaka, M; Morita, Y; Nagai, K; Shintani, N; Takeda, M; Tanaka, K; Tanida, M; Yamamoto, A, 2009) |
" Here we describe a mouse model of an anxiety/depressive-like state induced by chronic corticosterone treatment." | 7.75 | Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression. ( Antonijevic, IA; Artymyshyn, RP; Craig, DA; David, DJ; Drew, M; Gardier, AM; Gerald, C; Guiard, BP; Guilloux, JP; Hen, R; Leonardo, ED; Marsteller, D; Mendez, I; Rainer, Q; Samuels, BA; Wang, JW, 2009) |
"Cholecystokinin (CCK) involvement in depression-like disorders is poorly documented." | 7.74 | Repeated social defeat-induced depression-like behavioral and biological alterations in rats: involvement of cholecystokinin. ( Becker, C; Benoliel, JJ; Blugeot, A; Hamon, M; Rivat, C; Zeau, B, 2008) |
"A rat model of depression has been recently developed by exogenous corticosterone administration." | 7.74 | A mouse model of depression induced by repeated corticosterone injections. ( Du, L; Ma, R; Shen, J; Su, H; Xing, D; Zhao, Y, 2008) |
"A dysregulated hypothalamic-pituitary-adrenal axis (HPA) has been implicated in major depressive disorder and most commonly used animal models of depression have been shown to elevate circulating levels of plasma corticosterone." | 7.74 | Chronic low dose corticosterone exposure decreased hippocampal cell proliferation, volume and induced anxiety and depression like behaviours in mice. ( Hutson, PH; Murray, F; Smith, DW, 2008) |
"We investigated the influence of tiagabine on stress hormone release, cellular immune function and behaviour in rats following olfactory bulbectomy (OB), a well-recognized animal model of depression." | 7.74 | Tiagabine treatment is associated with neurochemical, immune and behavioural alterations in the olfactory bulbectomized rat model of depression. ( Dostalek, M; Jezova, D; Pistovcakova, J; Sulcova, A, 2008) |
" The purpose of the present study was to characterize the effect of repeated corticosterone (CORT) injections and repeated restraint stress on anxiety and depression-like behavior in male rats." | 7.73 | Effect of repeated corticosterone injections and restraint stress on anxiety and depression-like behavior in male rats. ( Davis, AC; Gregus, A; Kalynchuk, LE; Wintink, AJ, 2005) |
"Topiramate is currently used in the treatment of epilepsy, but this anticonvulsant drug has also been reported to exert mood-stabilizing effects and induce weight loss in patients." | 7.72 | Topiramate normalizes hippocampal NPY-LI in flinders sensitive line 'depressed' rats and upregulates NPY, galanin, and CRH-LI in the hypothalamus: implications for mood-stabilizing and weight loss-inducing effects. ( Bolwig, G; Husum, H; Mathé, A; Termeer, E; Van Kammen, D, 2003) |
"This experiment examined the effect of repeated corticosterone injections on anxiety and depression-like behavior in male and female rats." | 7.72 | Corticosterone increases depression-like behavior, with some effects on predator odor-induced defensive behavior, in male and female rats. ( Boudreau, D; Gregus, A; Kalynchuk, LE; Perrot-Sinal, TS, 2004) |
"The effects of chronic corticosterone treatment (100 mg pellet implanted for 1 week) were assessed in animal tests of anxiety, exploration and motor activity, and changes in binding to 5-HT1A and 5-HT2A receptors, and the 5-HT transporter, were measured." | 7.69 | Decreased 5-HT1A and increased 5-HT2A receptor binding after chronic corticosterone associated with a behavioural indication of depression but not anxiety. ( Fernandes, C; File, SE; McEwen, BS; McKittrick, CR, 1997) |
"Quercetin is a flavonoid compound, which has anti-inflammatory and antioxidant roles." | 5.91 | Quercetin mitigates depression-like behavior via the suppression of neuroinflammation and oxidative damage in corticosterone-induced mice. ( Ge, C; Lei, L; Wang, S; Wu, X, 2023) |
"anxiety and depression) are commonly observed in patients with epilepsy and induce seizure aggravation." | 5.72 | Transcranial Direct Current Stimulation Reduces Anxiety, Depression and Plasmatic Corticosterone in a Rat Model of Atypical Generalized Epilepsy. ( Antunes, GF; Castro, MC; Germann, J; Gomes, GCV; Gouveia, FV; Martinez, RCR; Oliveira, CC; Pinto, TRC; Valle, AC, 2022) |
"The success rate of the chronic pain-depression (CPD) model was 62." | 5.72 | A New Potential Antidepressant: Dexmedetomidine Alleviates Neuropathic Pain-Induced Depression by Increasing Neurogenesis in the Hippocampus. ( He, M; Xu, S; Zhang, X; Zhao, X; Zheng, X; Zhu, Z, 2022) |
"Major depression is a leading contributor to the global burden of disease." | 5.72 | Lower antidepressant response to fluoxetine is associated with anxiety-like behavior, hippocampal oxidative imbalance, and increase on peripheral IL-17 and IFN-γ levels. ( Becker, G; Bochi, GV; Camargo, LFM; da Silva Carlotto, M; Dos Santos, BM; Fialho, MFP; Oliveira, SM; Pereira, GC; Pillat, MM; Piton, E; Ramanzini, LG; Trevisan, G; Zanchet, EM, 2022) |
"Pregnancy is a very complex and highly stressful time in which women become more physically and emotionally vulnerable." | 5.72 | Swimming exercise strain-dependently affects maternal care and depression-related behaviors through gestational corticosterone and brain serotonin in postpartum dams. ( Ebrahimian, F; Masrour, FF; Najdi, N; Salari, AA, 2022) |
"Depression is a common, chronic, and often recurrent serious mood disorder." | 5.72 | Neuroprotective and Antioxidant Effects of Riparin I in a Model of Depression Induced by Corticosterone in Female Mice. ( Adelvane de Paula Rodrigues, F; Barbosa-Filho, JM; Cavalcanti Capibaribe, VC; Chavez Gutierrez, SJ; de Castro Chaves, R; Ferreira de Oliveira, N; Florenço de Sousa, FC; Lopes Sales, IS; Maia Oliveira, IC; Maria de França Fonteles, M; Rodrigues de Carvalho, AM; Rodrigues, GC; Teodorio Vidal, LM; Vasconcelos Mallmann, AS, 2022) |
"Depression was induced by 14 days of chronic restraint stress (CRS) daily for 4 h." | 5.62 | Therapeutic Potential of Curcumin in Reversing the Depression and Associated Pseudodementia via Modulating Stress Hormone, Hippocampal Neurotransmitters, and BDNF Levels in Rats. ( Afzal, A; Ahmad, S; Batool, Z; Haider, S; Kamil, N; Liaquat, L; Perveen, T; Sadir, S; Shahzad, S; Tabassum, S, 2021) |
" For this purpose, different animal models are used to study routes and molecular changes involved in depression, among them the chronic administration of corticosterone." | 5.56 | Glucocorticoid and brain-derived neurotrophic factor relationship: a brief investigation into the model of depression by chronic administration of corticosterone. ( Bochi, GV; Burger, ME; Pereira, GC; Roversi, K; Trevisan, G, 2020) |
"Corticosterone plasma level was increased in the CUMS compared to the non-stressed group (p < 0." | 5.56 | Valproic acid administration exerts protective effects against stress-related anhedonia in rats. ( Barati, M; Eslami, M; Goudarzi, M; Mehrabi, S; Nahavandi, A; Shahbazi, A, 2020) |
"Hair corticosterone was also assayed by liquid chromatography-mass spectrometry." | 5.56 | Effects of Chronic Cannabidiol Treatment in the Rat Chronic Unpredictable Mild Stress Model of Depression. ( Albert, Á; Farkas, S; Ferencz, E; Gáll, Z; Kolcsár, M; Urkon, M; Vancea, S, 2020) |
"Depression is recognized as a highly chronic and recurrent disorder." | 5.56 | Cyclical administration of corticosterone results in aggravation of depression-like behaviors and accompanying downregulations in reelin in an animal model of chronic stress relevant to human recurrent depression. ( Allen, J; Caruncho, HJ; Kalynchuk, LE; Kulhawy, EY; Lebedeva, KA, 2020) |
"Depression is closely linked to hypothalamus-pituitary-adrenal axis hyperactivity." | 5.56 | Antidepressant-like mechanism of honokiol in a rodent model of corticosterone-induced depression. ( Chang, HS; Duan, XH; Hu, KL; Li, LN; Li, Y; Liu, M; Yu, X; Zhang, B, 2020) |
"2-Phenethylamine (PEA) is a monoamine alkaloid that acts as a central nervous system stimulant in humans." | 5.56 | 2-Phenylethylamine (PEA) Ameliorates Corticosterone-Induced Depression-Like Phenotype via the BDNF/TrkB/CREB Signaling Pathway. ( Hwang, DY; Hyun, SA; Ka, M; Kim, HR; Ko, MY; Lee, BS; Lee, CY; Lee, YJ, 2020) |
"Depression is a very common psychiatric disorder affecting approximately 300 million people worldwide with the prevalence being twice as high in women as in men." | 5.51 | Effect of Chronic Corticosterone Treatment on Depression-Like Behavior and Sociability in Female and Male C57BL/6N Mice. ( Berger, S; Gureczny, S; Horvath, O; Pollak, DD; Reisinger, SN, 2019) |
"Depression is the leading cause of mental health-related disease globally, and it affects an estimated 300 million people worldwide." | 5.51 | Antidepressant activity of crocin-I is associated with amelioration of neuroinflammation and attenuates oxidative damage induced by corticosterone in mice. ( Fu, Z; Shen, Q; Wang, L; Xiao, Q; Xie, X; Xiong, Z; Yu, C; Zhou, J, 2019) |
" RESULTS The results showed that the extract at the dosage of 50 and 100 mg/kg significantly (p<0." | 5.51 | Antidepressive Effects of Taraxacum Officinale in a Mouse Model of Depression Are Due to Inhibition of Corticosterone Levels and Modulation of Mitogen-Activated Protein Kinase Phosphatase-1 (Mkp-1) and Brain-Derived Neurotrophic Factor (Bdnf) Expression. ( Duan, H; Gao, C; Guo, B; Kong, S; Li, D; Liang, X, 2019) |
"Treatment with crocin, exposure to wheel running activity, and the combined interventions alleviated both behavioral and morphological deficits induced by adolescent stress." | 5.51 | Beneficial Effects of Physical Activity and Crocin Against Adolescent Stress Induced Anxiety or Depressive-Like Symptoms and Dendritic Morphology Remodeling in Prefrontal Cortex in Adult Male Rats. ( Ghalandari-Shamami, M; Nourizade, S; Pakdel, R; Rashidy-Pour, A; Vafaei, AA; Yousefi, B, 2019) |
"Quercetin treatment was found to significantly reduce anxiety-like behaviors in mTBI-induced mice." | 5.51 | Quercetin mitigates anxiety-like behavior and normalizes hypothalamus-pituitary-adrenal axis function in a mouse model of mild traumatic brain injury. ( Ghorbanihaghjo, A; Kosari-Nasab, M; Mesgari-Abbasi, M; Salari, AA; Shokouhi, G, 2019) |
"Corticosterone treatment altered all parameters in behavioral tests, leading to a depressive- and anxious-like behavior." | 5.51 | Reversal effect of Riparin IV in depression and anxiety caused by corticosterone chronic administration in mice. ( Barbosa Filho, JM; Capibaribe, VCC; Chaves, RC; da Silva, DMA; de Carvalho, AMR; de Sousa, FCF; Gutierrez, SJC; Lopes, IS; Macêdo, DS; Mallmann, ASV; Oliveira, ICM; Oliveira, NF; Valentim, JT; Vasconcelos, SMM, 2019) |
" We also examined whether Roman chamomile combined with clomipramine treatment affects hippocampal neurogenesis and serum corticosterone levels." | 5.51 | Roman chamomile inhalation combined with clomipramine treatment improves treatment-resistant depression-like behavior in mice. ( Hashikawa, N; Hashikawa-Hobara, N; Ishikawa, R; Otsuka, A, 2019) |
"Depression is commonly associated with hypothalamic-pituitary adrenal (HPA) axis dysfunction that primarily manifests as aberrant glucocorticoid secretion." | 5.48 | Differential effects of imipramine and CORT118335 (Glucocorticoid receptor modulator/mineralocorticoid receptor antagonist) on brain-endocrine stress responses and depression-like behavior in female rats. ( Balmer, NJ; Caldwell, JL; Estrada, CM; Ghisays, V; Nguyen, ET; Solomon, MB; Streicher, J, 2018) |
"Oxytocin (OXT) has been considered as a neuroregulator mediating social behaviors and stress-related disorders." | 5.48 | Injection of oxytocin into paraventricular nucleus reverses depressive-like behaviors in the postpartum depression rat model. ( Li, H; Li, X; Liu, B; Shi, C; Wang, H; Wang, T; Wang, Y; Wu, Y; Xu, ZD; Yang, Y; Zhang, P, 2018) |
"Baicalin treatment inhibited APPL2/GR signaling pathway and improved neurogenesis at SVZ, OB, and hippocampus in APPL2 Tg mice and chronic corticosterone-induced depression mouse model." | 5.48 | Baicalin Modulates APPL2/Glucocorticoid Receptor Signaling Cascade, Promotes Neurogenesis, and Attenuates Emotional and Olfactory Dysfunctions in Chronic Corticosterone-Induced Depression. ( Deng, R; Du, Q; Gao, C; Li, W; Shen, J; Wang, Q; Xu, A, 2018) |
"Corticosterone pre-treatment generated oxidative stress, altering antioxidant enzymes in the nervous tissue." | 5.48 | Antioxidant and antidepressant-like effects of Eugenia catharinensis D. Legrand in an animal model of depression induced by corticosterone. ( Alberton, MD; Barauna, SC; Brueckheimer, MB; de Albuquerque, CAC; de Gasper, AL; de Melo, DFM; Delwing-Dal Magro, D; Delwing-De Lima, D; Döhler, AW; Harger, MC; Maia, TP; Micke, GA; Sala, GABN; Siebert, DA, 2018) |
"Insulin resistance has been identified as the key mechanism linking depression and diabetes." | 5.46 | Curcumin reverses the depressive-like behavior and insulin resistance induced by chronic mild stress. ( Li, YC; Li, YJ; Qiao, JY; Shen, JD; Wei, Y, 2017) |
"Recently, depression has been envisioned as more than an alteration in neurotransmitters centered around receptor signaling pathways." | 5.46 | Fluoxetine coupled with zinc in a chronic mild stress model of depression: Providing a reservoir for optimum zinc signaling and neuronal remodeling. ( Omar, NN; Tash, RF, 2017) |
"Comorbid depression was induced by five inescapable foot-shocks (2mA, 2ms duration) at 10s intervals on days 1, 5, 7, and 10." | 5.46 | Metformin and ascorbic acid combination therapy ameliorates type 2 diabetes mellitus and comorbid depression in rats. ( Kumar, M; Nayak, PK; Shivavedi, N; Tej, GNVC, 2017) |
"Depression has become a common public health problem that is showing increasing prevalence." | 5.46 | Evaluation of the antidepressant-like effect of musk in an animal model of depression: how it works. ( Ayuob, NN, 2017) |
"Depression is a common psychopathological disorders." | 5.43 | Zinc and imipramine reverse the depression-like behavior in mice induced by chronic restraint stress. ( Ding, Q; Huang, J; Li, H; Mo, F; Shen, H; Shen, Z; Tian, X; Wang, X, 2016) |
"Musk has an antidepressant-like effect in an animal model of depression, so it is advisable to assess its efficacy in people continually exposed to stressors." | 5.43 | The antidepressant effect of musk in an animal model of depression: a histopathological study. ( Ahmed, SM; Ali, SS; Ayuob, NN; El Wahab, MGA; Suliaman, M, 2016) |
" Chronic administration of BB effectively reversed these alterations." | 5.43 | Bilobalide alleviates depression-like behavior and cognitive deficit induced by chronic unpredictable mild stress in mice. ( Shui, L; Song, Z; Tai, F; Wang, S; Wu, R, 2016) |
" Repeated CORT dosing caused depression-like behavior in mice as indicated by increased despair effects in forced swim test (FST) and anhedonia in sucrose preference test." | 5.42 | Effect of a novel 5-HT3 receptor antagonist 4i, in corticosterone-induced depression-like behavior and oxidative stress in mice. ( Gupta, D; Kurhe, Y; Radhakrishnan, M, 2015) |
"Chronic pain and depression are two complex states that often coexist in the clinical setting and traditional antidepressants and analgesics have shown limited clinical efficacy." | 5.42 | m-Trifluoromethyl-diphenyl diselenide, a multi-target selenium compound, prevented mechanical allodynia and depressive-like behavior in a mouse comorbid pain and depression model. ( Brüning, CA; Duarte, MM; Gai, BM; Martini, F; Nogueira, CW; Sampaio, TB; Soares, SM, 2015) |
"Anxiety and depression are common in diabetics." | 5.40 | Anxiety- and depression-like behavior are correlated with leptin and leptin receptor expression in prefrontal cortex of streptozotocin-induced diabetic rats. ( Agilkaya, S; Aksu, I; Ates, M; Baykara, B; Buyuk, E; Cetinkaya, C; Cingoz, S; Dayi, A; Kiray, M; Sisman, AR; Uysal, N, 2014) |
"The corticosterone-treated rats showed significantly reduced sleep time, disinhibition of rapid-eye-movement (REM) sleep and altered power spectra during non-REM sleep." | 5.40 | Correlations between depression behaviors and sleep parameters after repeated corticosterone injections in rats. ( Cao, Q; Cui, SY; Cui, XY; Huang, YL; Li, SJ; Sheng, ZF; Wang, ZJ; Yu, B; Zhang, XQ; Zhang, YH, 2014) |
" Additionally, the effects of chronic administration of the tricyclic antidepressant imipramine and the anti-TNF-α pentoxyphylline were investigated." | 5.40 | Lipopolysaccharide repeated challenge followed by chronic mild stress protocol introduces a combined model of depression in rats: reversibility by imipramine and pentoxifylline. ( Abd-Alkhalek, HA; Abdel-tawab, AM; Aboul-Fotouh, S; El Tabbal, M; Elgarf, AS; Farrag, KA; Hammouda, GA; Hassan, AN; Kassim, SK, 2014) |
"Corticosterone treatment induced longer immobility times in the FST, reflecting depressive-like behaviour." | 5.40 | Long-term corticosterone exposure decreases insulin sensitivity and induces depressive-like behaviour in the C57BL/6NCrl mouse. ( Blokland, A; Cañete, R; Pawluski, JL; Sierksma, AS; Steinbusch, HW; Vaessen, KR; van Donkelaar, EL, 2014) |
"Honokiol (HNK) is a biphenolic neolignan possessing multiple biological activities including antioxidant, anti-inflammatory, anxiolytic, antidepressant and neuroprotective." | 5.40 | Honokiol abrogates lipopolysaccharide-induced depressive like behavior by impeding neuroinflammation and oxido-nitrosative stress in mice. ( Baruah, CC; Dwivedi, S; Hazarika, NK; Jangra, A; Kumar, P; Lahkar, M; Sulakhiya, K, 2014) |
"Depression has been considered to be both a symptom and risk factor of AD." | 5.39 | Effects of corticosterone and amyloid-beta on proteins essential for synaptic function: implications for depression and Alzheimer's disease. ( Chang, RC; Cheng, SS; Ho, YS; Hung, CH; Law, AC; Wong, GT; Wuwongse, S; Zhang, NQ, 2013) |
"Corticosterone secretion was significantly high in the ELF-MF-exposed mice; however, no changes were observed in the amount of the adrenocorticotropic hormone and the expression of genes related to stress response." | 5.39 | Chronic exposure to an extremely low-frequency magnetic field induces depression-like behavior and corticosterone secretion without enhancement of the hypothalamic-pituitary-adrenal axis in mice. ( Aoi, S; Kitamura, M; Kitaoka, K; Shimizu, N; Yoshizaki, K, 2013) |
"Treatment with mifepristone decreased immobility and increased swimming (but not climbing) behavior in the FST, consistent with anti-depressant action." | 5.36 | Mifepristone decreases depression-like behavior and modulates neuroendocrine and central hypothalamic-pituitary-adrenocortical axis responsiveness to stress. ( Herman, JP; Solomon, MB; Wulsin, AC, 2010) |
"Phenelzine did not increase paraventricular hypothalamus CRH or vasopressin mRNA in ADX mice lacking corticosterone replacement." | 5.33 | Chronic treatment with the monoamine oxidase inhibitor phenelzine increases hypothalamic-pituitary-adrenocortical activity in male C57BL/6 mice: relevance to atypical depression. ( Han, J; Jacobson, L; Kier, A, 2005) |
"Electroconvulsive seizure (ECS)-treatment, an animal model for the antidepressant treatment electroconvulsive therapy, can enhance proliferation of glial cells." | 5.33 | Corticosterone-induced inhibition of gliogenesis in rat hippocampus is counteracted by electroconvulsive seizures. ( Ekstrand, J; Hellsten, J; Lindgren, H; Tingström, A; Wennström, M, 2006) |
"Corticosterone treatment was found to induce a significant attenuation in the response to 8-OHDPAT, indicating functional desensitization of somatodendritic 5-HT(1A) autoreceptors." | 5.32 | Flattening the corticosterone rhythm attenuates 5-HT1A autoreceptor function in the rat: relevance for depression. ( Gartside, SE; Ingram, CD; Leitch, MM; McQuade, R; Young, AH, 2003) |
" In this study we have evaluated the MMP-9 activity and protein expression in brain areas relevant to depression using the chronic corticosterone mouse model of depression." | 4.31 | Brain matrix metalloproteinase-9 activity is altered in the corticosterone mouse model of depression. ( Breviario, S; Castro, E; Díaz, Á; Florensa-Zanuy, E; Garro-Martínez, E; Pazos, Á; Pilar-Cuéllar, F; Senserrich, J, 2023) |
" Thereafter, behavior parameters (sucrose preference test, forced-swimming test, open-field test, body weight), pro-inflammatory cytokines, neurotransmitters, adrenocorticotropic hormone (ACTH), corticosterone (CORT), and liver biomarkers were studied." | 4.31 | 18β-Glycyrrhetinic Acid Ameliorates Neuroinflammation Linked Depressive Behavior Instigated by Chronic Unpredictable Mild Stress via Triggering BDNF/TrkB Signaling Pathway in Rats. ( Gupta, GL; Sharma, L; Sharma, M, 2023) |
"Ketamine is an anesthetic drug that has recently been approved for the treatment of treatment-resistant depression." | 4.31 | The Effects of Acute and Repeated Administration of Ketamine on Memory, Behavior, and Plasma Corticosterone Levels in Female Mice. ( Acevedo, J; Johnson, EM; Mugarura, NE; Siegel, JA; Welter, AL, 2023) |
"Here, we employed mouse models of depression induced by chronic unpredictable stress exposure or corticosterone (CORT) stimulation." | 4.31 | MAD2B Blunts Chronic Unpredictable Stress and Corticosterone Stimulation-Induced Depression-Like Behaviors in Mice. ( Meng, X; Miao, C; Su, Y; Wang, XL; Zhang, C, 2023) |
" Pups whose dams consumed the HFS diet during gestation and lactation exhibited increased depression-related behavior and baseline serum corticosterone levels, but no difference in peak levels in response to stress." | 4.31 | Comparison of maternal versus postweaning ingestion of a high fat, high sucrose diet on depression-related behavior, novelty reactivity, and corticosterone levels in young, adult rat offspring. ( Farber, C; Koh, GY; Lane, MA; McKenzie, A; Muraida, JD; Renteria, K; Ritter, J; Rivers, C; Zhu, J, 2023) |
"The corticosterone (CORT)-induced depression mouse model was used to evaluate the therapeutic efficacy of JTW." | 4.12 | Anti-depressive effects of Jiao-Tai-Wan on CORT-induced depression in mice by inhibiting inflammation and microglia activation. ( Bai, G; Duan, L; Huang, S; Li, M; Lo, PC; Qiao, Y; Song, L; Wang, Q; Wei, S; Yang, C; Yang, Y; Zhang, B, 2022) |
"Mirtazapine (MIRT) is a multi-target antidepressant used in treatment of severe depression with promising efficacy, but also with important side effects, mainly sedation and weight gain." | 4.12 | Lipoic acid prevents mirtazapine-induced weight gain in mice without impairs its antidepressant-like action in a neuroendocrine model of depression. ( Chaves Filho, AJM; Cunha, NL; De Oliveira, GMF; Gadelha Filho, CVJ; Jucá, PM; Macedo, DS; Oliveira, TQ; Soares, MVR; Vasconcelos, SMM; Viana, GA; Vieira, CFX, 2022) |
"Selective serotonergic reuptake inhibitors, including fluoxetine (FLX), are the most commonly used for the treatment of major depression." | 4.12 | Galanin (1-15) Enhances the Behavioral Effects of Fluoxetine in the Olfactory Bulbectomy Rat, Suggesting a New Augmentation Strategy in Depression. ( Cantero-García, N; Díaz-Cabiale, Z; Flores-Burgess, A; Fuxe, K; Gago, B; García-Durán, L; Millón, C; Narváez, JA; Puigcerver, A; Santín, L, 2022) |
" To evaluate the antidepressant-like effects of FMN, a mice model of depression was established by chronic corticosterone (CORT) injection." | 4.12 | The antidepressant-like effect of formononetin on chronic corticosterone-treated mice. ( Bai, M; Li, M; Li, Y; Lu, S; Xu, E; Zhang, C; Zhu, L, 2022) |
" Changes of serotonin (5-HT), dopamine (DA), norepinephrine (NE), serum corticosterone (CORT), adrenocorticotropic hormone (ACTH), organ index, and histopathology in brain tissue, to explore the treatment and characteristics of total white glucosides in depression model, were prepared by different stimuli in 21 days." | 4.12 | Pharmacological Study on Total Glycosides of Xiebai Protecting against Depression Model. ( Jiang, M; Miao, M; Zhao, H, 2022) |
"The aim of this study was to investigate the antidepressant effect of Jujuboside A (JuA) on corticosterone (CORT)-induced depression in mice and explore the underlying mechanisms." | 4.12 | Antidepressant effect of Jujuboside A on corticosterone-induced depression in mice. ( Gong, J; Li, H; Li, J; Xie, X; Zhang, T, 2022) |
" PPD rat models were prepared by withdrawing hormone‑simulated pregnancy (HSP), and subjects were treated with paeoniflorin and fluoxetine or plasmids." | 4.12 | Paeoniflorin exhibits antidepressant activity in rats with postpartum depression via the TSPO and BDNF‑mTOR pathways. ( Chen, J; Hu, L; Peng, H; Yang, K; Zeng, X; Zhu, W, 2022) |
"Sustained elevation of corticosterone (CORT) is one of the common causes of aging and major depression disorder." | 4.02 | Low corticosterone levels attenuate late life depression and enhance glutamatergic neurotransmission in female rats. ( Chen, NH; Chu, SF; Cui, LY; He, HY; He, WB; Wang, ZZ; Yang, B; Zhang, Z; Zhou, X, 2021) |
" Thus, the effects of naringenin, a potent antioxidant, anti-inflammatory and neuroprotective bioflavonoid on hypoxic stress-induced depressive-like and anxiety-related behaviors in mice, and the underlying molecular mechanisms were evaluated in this study." | 4.02 | Naringenin improves depressive- and anxiety-like behaviors in mice exposed to repeated hypoxic stress through modulation of oxido-inflammatory mediators and NF-kB/BDNF expressions. ( Ajayi, AM; Bakre, AG; Ben-Azu, B; Femi-Akinlosotu, O; Olugbemide, AS; Umukoro, S, 2021) |
"Emerging evidence has shown that ursolic acid exerts antidepressant-like effects, however, its ability to elicit an antidepressant-like response in rodents subjected to stress model that mimics behavioral and neurochemical alterations found in depression remains to be determined." | 4.02 | Ursolic acid abrogates depressive-like behavior and hippocampal pro-apoptotic imbalance induced by chronic unpredictable stress. ( Camargo, A; Colla, ARS; Lieberknecht, V; Pazini, FL; Rodrigues, ALS, 2021) |
"Intranasal treatment with oxytocin showed beneficial effects in post-traumatic stress disorder and autism spectrum disorders; however, it was not investigated as much in depression." | 4.02 | Synergy of oxytocin and citalopram in modulating Itgb3/Chl1 interplay: Relevance to sensitivity to SSRI therapy. ( Batinić, B; Gurwitz, D; Israel-Elgali, I; Jukić, M; Oved, K; Pešić, V; Puškaš, N; Shomron, N; Stanić, D, 2021) |
" In this study, an ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed to detect the concentration of corticosterone (CORT) and its metabolites, progesterone (PROG) and testosterone in rat plasma and prefrontal cortex (PFC), and was applied to investigate the changes in hormones in rats with depression induced by chronic unpredictable mild stress (CUMS)." | 4.02 | Quantitation of six steroid hormones by ultra-performance liquid chromatography-tandem mass spectrometry in plasma and prefrontal cortex samples from rats with chronic unpredictable mild stress-induced depression. ( Han, X; Li, X; Lu, Y; Qin, Y; Rang, Y; Zhai, X; Zhu, Y, 2021) |
" The treatments with ketamine, guanosine, and ketamine plus guanosine were effective to counteract corticosterone-induced anxiety-like phenotype, but not disturbances in the hippocampal NLRP3 pathway." | 4.02 | Low doses of ketamine and guanosine abrogate corticosterone-induced anxiety-related behavior, but not disturbances in the hippocampal NLRP3 inflammasome pathway. ( Camargo, A; Dalmagro, AP; Fraga, DB; Kaster, MP; Rodrigues, ALS; Rosa, JM; Zeni, ALB, 2021) |
" Here, we assessed severity in a cognitive depression model by analysing indicators of stress and well-being, including physiological (body weight and corticosterone metabolite concentrations) and behavioural (nesting and burrowing behaviour) parameters." | 3.96 | Systematic analysis of severity in a widely used cognitive depression model for mice. ( Bleich, A; Brandwein, C; Chourbaji, S; Gass, P; Häger, C; Hellweg, R; Inta, D; Mallien, AS; Palme, R; Pfeiffer, N; Struve, B; Talbot, SR; Vogt, MA; Vollmayr, B, 2020) |
" Here, we investigated the effects of stress exposure via two types of restraint apparatuses on body weight, locomotor activity, anxiety- and depression-related behaviors, and plasma corticosterone levels in mice." | 3.96 | Differential effects of stress exposure via two types of restraint apparatuses on behavior and plasma corticosterone level in inbred male BALB/cAJcl mice. ( Miyakawa, T; Shoji, H, 2020) |
" Epilepsy-associated comorbid depression was evaluated by tail suspension test, sucrose preference test, and plasma corticosterone levels, whereas epilepsy-associated memory deficit condition was assessed by step-through paradigm, Morris water maze, and nitrite levels." | 3.96 | Exploring the ameliorative role of α7 neuronal nicotinic acetylcholine receptor modulation in epilepsy and associated comorbidities in post-PTZ-kindled mice. ( Goel, RK; Kaur, S; Sharma, NK, 2020) |
" Body weight, levels of plasma corticosterone, hippocampal pro-and anti-inflammatory cytokines, anxiety-like (novelty suppressed feeding and elevated plus maze) and motivated behaviors (sucrose negative contrast test and forced swim test) were evaluated three days after the end of the chronic protocol." | 3.96 | Chronic unpredictable restraint stress increases hippocampal pro-inflammatory cytokines and decreases motivated behavior in rats. ( Covolan, L; da Silva, SG; Hamani, C; Mograbi, KM; Suchecki, D, 2020) |
" Here we aimed to compare the effects of (R)-norketamine ((R)-NK), (S)-NK, (2R,6R)-HNK, and (2S,6S)-HNK in a mouse model of depression induced by chronic corticosterone (CORT) injection." | 3.96 | (S)-norketamine and (2S,6S)-hydroxynorketamine exert potent antidepressant-like effects in a chronic corticosterone-induced mouse model of depression. ( Ago, Y; Chen, L; Hashimoto, H; Hashimoto, K; Higuchi, M; Kasai, A; Naito, M; Nakagawa, S; Nakazawa, T; Seiriki, K; Tanabe, W; Tsukada, S; Yamaguchi, T; Yokoyama, R, 2020) |
" Here, we decided to investigate how the duration of the CUMS procedure affects behavioural changes, body weight as well as the level of plasma corticosterone in stressed and nonstressed C57BL/6J mice subjected to CUMS for 18 or 36 days." | 3.96 | The influence of the duration of chronic unpredictable mild stress on the behavioural responses of C57BL/6J mice. ( Brański, P; Burnat, G; Pałucha-Poniewiera, A; Podkowa, K; Rafało-Ulińska, A, 2020) |
"As a continuation of our previous experiments, this study aimed to investigate the antidepressant- and anxiolytic-like activity of pitolisant in mice using the corticosterone-induced depression model." | 3.96 | Pitolisant protects mice chronically treated with corticosterone from some behavioral but not metabolic changes in corticosterone-induced depression model. ( Kieć-Kononowicz, K; Kotańska, M; Mika, K; Pytka, K; Sapa, J; Sałaciak, K; Wheeler, L, 2020) |
"Accordingly, we evaluated the effect of NAC on neonatal clomipramine (CLI)-induced adulthood anxiety and accompanying changes in plasma corticosterone levels, amygdalar volumes, neuronal/glial densities, levels of monoamines, and their metabolites in the amygdalar complex." | 3.96 | Mechanisms underlying remediation of depression-associated anxiety by chronic N-acetyl cysteine treatment. ( Chakraborty, S; Raju, TR; Shankaranarayana Rao, BS; Tripathi, SJ, 2020) |
" Considering that ketamine has significant knock-on effects, this study investigated the effects of a single coadministration with subthreshold doses of ketamine plus guanosine in a corticosterone (CORT)-induced animal model of depression and the role of anti-inflammatory and antioxidant pathways." | 3.96 | Subthreshold doses of guanosine plus ketamine elicit antidepressant-like effect in a mouse model of depression induced by corticosterone: Role of GR/NF-κB/IDO-1 signaling. ( B Zeni, AL; Camargo, A; Dalmagro, AP; M Rosa, J; P Kaster, M; S Rodrigues, AL; Tasca, CI, 2020) |
"This study assessed the effect of swimming training on anxiety-like behaviors and corticosterone." | 3.96 | The Effect of Swimming on Anxiety-Like Behaviors and Corticosterone in Stressed and Unstressed Rats. ( Aligholi, H; Brand, S; Koushkie Jahromi, M; Rezaei, R; Safari, MA, 2020) |
" The maternal separation model involving three hour daily maternal separation (MS) from pups on PPD 2-15 on anxiety-, depression- and anhedonia-like behaviors in the dams was investigated, together with plasma corticosterone, oxytocin and D1-D2 heteromer expression in the NAc core and shell in non-MS and MS dams." | 3.96 | Maternal Separation Model of Postpartum Depression: Potential Role for Nucleus Accumbens Dopamine D1-D2 Receptor Heteromer. ( George, SR; Hasbi, A; Milenkovic, M; Noori, M; Sivasubramanian, M, 2020) |
"A total of 36 rats were randomly assigned to three groups: a normal group, model group (depression), and treatment group (depression + gentiopicroside)." | 3.91 | Metabolomic evidence for the therapeutic effect of gentiopicroside in a corticosterone-induced model of depression. ( Cui, Q; Liu, Z; Wang, C; Wang, G; Yao, T; Zhang, Q, 2019) |
"Chronic corticosterone (CORT) stress is an anxiety and depression inducing factor that involves the dysfunction of glucocorticoid receptor (GR), brain-derived neurotrophic factor (BDNF), and neuronal plasticity." | 3.91 | Proteomic profiling of the neurons in mice with depressive-like behavior induced by corticosterone and the regulation of berberine: pivotal sites of oxidative phosphorylation. ( Du, LJ; Feng, YL; Gao, HW; Gong, Q; He, LL; Lei, F; Li, J; Luo, YY; Wang, ML; Yan, XJ; Yang, SL, 2019) |
" A treatment with escitalopram reversed depression-like behavior accompanied by reductions in BDNF levels in serum and the nucleus accumbens, while a treatment with blonanserin ameliorated abnormal social interaction behavior with reductions in serum BDNF levels." | 3.91 | Antidepressant activities of escitalopram and blonanserin on prenatal and adolescent combined stress-induced depression model: Possible role of neurotrophic mechanism change in serum and nucleus accumbens. ( Deriha, K; Furuse, K; Hashiguchi, H; Hashimoto, E; Ishii, T; Kawanishi, C; Kigawa, Y; Shiraishi, M; Tayama, M; Ukai, W, 2019) |
" This study investigated antidepressant-like effects and possible underlying mechanisms of Lactobacillus paracasei PS23 (PS23), live or heat-killed, in a mouse model of corticosterone-induced depression using fluoxetine as standard drug." | 3.91 | Antidepressant-like activities of live and heat-killed Lactobacillus paracasei PS23 in chronic corticosterone-treated mice and possible mechanisms. ( Cheng, YF; Hsu, CC; Liao, CL; Tsai, YC; Wang, S; Wei, CL; Wu, CC; Yen, JT, 2019) |
" We then measured the body weight and performed the sucrose preference test, forced swimming test (FST) and open field test to detect the effects of stress on anhedonia and activity." | 3.91 | DNA methylation of the Tacr2 gene in a CUMS model of depression. ( Fu, L; Liu, Z; Wan, Q; Wang, G; Xiang, D; Xiao, J; Xiao, L; Yao, L; Zhu, F, 2019) |
" An animal model of chronic administration of high dose corticosterone to induce depression- and anxiety-like behavior and reduced neurogenesis was used to explore the biological changes brought by aromatherapy." | 3.91 | Lavender essential oil ameliorates depression-like behavior and increases neurogenesis and dendritic complexity in rats. ( Chow, JK; Fung, TK; Lau, BW; Lau, WK; Po, KK; Sánchez-Vidaña, DI; So, PK; Tsang, HW, 2019) |
" This study utilized a translational animal model of maternal depression (based on giving high levels of corticosterone (CORT, 40 mg/kg, s." | 3.91 | Developmental outcomes after gestational antidepressant treatment with sertraline and its discontinuation in an animal model of maternal depression. ( Brummelte, S; Kott, JM; Mooney-Leber, SM, 2019) |
"Chronic methamphetamine (MA) use can lead to increased symptoms of depression and anxiety during abstinence." | 3.91 | Stress-induced neural activation is altered during early withdrawal from chronic methamphetamine. ( Brooks, ML; Jacobskind, JS; Rosinger, ZJ; Zuloaga, DG, 2019) |
"Our previous finding demonstrated that chronic corticosterone (CORT) may be involved in mediating the pathophysiology of premature aging in rats." | 3.91 | Exposure to jet lag aggravates depression-like behaviors and age-related phenotypes in rats subject to chronic corticosterone. ( Fu, Z; Ni, Y; Shen, Q; Wang, X; Wu, J; Xiao, Q; Xie, X; Yu, C; Zhou, J, 2019) |
"20(S)-Protopanaxadiol (PPD) is a basic aglycone of the dammarane triterpenoid saponins and exerts antidepressant-like effects on behaviour in the forced swimming test (FST) and tail suspension test (TST) and in rat olfactory bulbectomy depression models." | 3.91 | Antidepressant-like effects of 20(S)-protopanaxadiol in a mouse model of chronic social defeat stress and the related mechanisms. ( Huang, H; Jiang, N; Liu, XM; Lu, C; Lv, GH; Lv, JW; Wang, HX; Wang, Q; Xia, TJ; Yang, YJ, 2019) |
" In this study, we examined the molecular effects associated with a response to a week-long treatment with escitalopram in the chronic escape deficit (CED) model, a validated model of depression based on the induction of an escape deficit after exposure of rats to an unavoidable stress." | 3.88 | Molecular changes associated with escitalopram response in a stress-based model of depression. ( Alboni, S; Benatti, C; Blom, JMC; Brunello, N; Mendlewicz, J; Tascedda, F, 2018) |
"Many models, such as chronic mild stress, chronic stress or chronic corticosterone injections are used to induce depression associated with cognitive deficits." | 3.88 | Combined corticosterone treatment and chronic restraint stress lead to depression associated with early cognitive deficits in mice. ( Bahane, DAN; Bum, EN; Ngoupaye, GT; Yassi, FB, 2018) |
"Oral administration of WGE improved depression-like behaviors and stress-induced elevations of corticosterone." | 3.88 | Antidepressant-like effects of water extract of Gastrodia elata Blume on neurotrophic regulation in a chronic social defeat stress model. ( Chou, ST; Ho, CT; Lai, YS; Lin, SH; Lin, YE; Lu, KH; Panyod, S; Sheen, LY, 2018) |
" The sucrose consumption test, forced swim test (FST) and the level of plasma corticosterone (CORT) were employed to evaluate depression-like symptoms in rats." | 3.88 | Blue light filtered white light induces depression-like responses and temporary spatial learning deficits in rats. ( Chu, H; Hao, W; Hou, X; Jiang, J; Lian, Y; Meng, Q; Pan, Y; Shang, L; Wang, W; Wei, X, 2018) |
" Magnolol, main constituent identified in the barks of Magnolia officinalis, exerted antidepressant effects in a rat model of depression induced by chronic unpredictable mild stress in previous studies." | 3.88 | Antidepressant effects of magnolol in a mouse model of depression induced by chronic corticosterone injection. ( Bai, Y; Dai, G; Jing, W; Ju, W; Song, L; Xu, M; Zhang, W; Zhu, L, 2018) |
"To investigate the effects of stress-induced depression, in the present study, we evaluated behavior by forced swimming test (FST), corticosterone plasma level by ELISA assay, hippocampal mRNA expression of three genes (NGF, kinesin and dynein) via real-time PCR and hippocamp count by Nissl staining in male Wistar rats." | 3.88 | Axonal transport proteins and depressive like behavior, following Chronic Unpredictable Mild Stress in male rat. ( Bakhtiarzadeh, F; Goudarzi, M; Nahavandi, A; Niknazar, S; Rakhshan, K; Shirvalilou, S, 2018) |
" Therefore, we tested this hypothesis in the depression model of chronic administration of corticosterone (CORT) in mice and treated the animals daily with liraglutide (5 or 20 nmol/kg ip." | 3.88 | Liraglutide attenuates the depressive- and anxiety-like behaviour in the corticosterone induced depression model via improving hippocampal neural plasticity. ( Birong, L; Christian, H; Feiyu, S; Le, W; Weina, H; Yuhu, N, 2018) |
" We also assessed maternal behaviours and 2 stress markers: basal vs acute-evoked stress levels of serum corticosterone and body weight gain." | 3.88 | Effects of prenatal stress on anxiety- and depressive-like behaviours are sex-specific in prepubertal rats. ( Arriagada-Solimano, M; Dagnino-Subiabre, A; Iturra-Mena, AM; Luttecke-Anders, A, 2018) |
" As expected, CVS significantly increased anxiety- and depressive-like behaviors and corticosterone levels and decreased GFAP expression in astroglia, although this did not reflect a change in the total number of astroglial cells." | 3.88 | Profiling changes in cortical astroglial cells following chronic stress. ( Coppola, G; Hayley, S; McQuaid, RJ; Rudyk, CA; Salmaso, N; Simard, S, 2018) |
" Indeed, PRS increased Sub offspring's serum corticosterone, and exaggerated their anxiety- and depressive-like behavior, while Dom offspring remained resilient to the hormonal and behavioral consequences of PRS." | 3.88 | Social dominance predicts hippocampal glucocorticoid receptor recruitment and resilience to prenatal adversity. ( Gross, M; Miller, A; Pinhasov, A; Romi, H, 2018) |
" The present study aimed to examine effects on regional brain activity of two frequently used depression models, the chronic unpredictable mild stress (CUMS)- and the chronic corticosterone (CORT) depression model." | 3.88 | Regional alterations of cerebral [ ( Baeken, C; Brans, B; De Vos, F; Descamps, B; Dockx, R; Goethals, I; Pauwelyn, G; Peremans, K; Van Laeken, N; Vanhove, C, 2018) |
" This study aimed to investigate the activity of RIP II in a corticosterone-induced depression mice model." | 3.88 | Riparin II ameliorates corticosterone-induced depressive-like behavior in mice: Role of antioxidant and neurotrophic mechanisms. ( Barbosa Filho, JM; Capibaribe, VCC; Chaves, RC; da Silva, DMA; de Araújo, MA; de Sousa, FCF; de Souza, AG; Gutierrez, SJC; Lopes, IS; Macêdo, DS; Oliveira, ICM; Valentim, JT, 2018) |
" We used a well-characterized anxiety/depressive-like mouse model consisting of continuous input of corticosterone for seven consecutive weeks." | 3.88 | Adiporon, an adiponectin receptor agonist acts as an antidepressant and metabolic regulator in a mouse model of depression. ( Bayer, P; Béchade, C; Chabry, J; Debayle, D; Gay, AS; Guyon, A; Heurteaux, C; Maroteaux, L; Nicolas, S, 2018) |
" The corticosterone rat model was developed to understand the influence of stress on depression-like symptomatology." | 3.88 | Depression-like behaviors induced by chronic corticosterone exposure via drinking water: Time-course analysis. ( Cui, SY; Cui, XY; Ding, H; Hu, X; Liu, YT; Ye, H; Zhang, YH; Zhao, HL, 2018) |
"In recent years, a substantial amount of experimental studies have demonstrated that exogenous administration of corticosterone causes anxiety and depressive-like behaviour in rodents which involves hypothalamic-pituitary-adrenal axis dysregulation." | 3.85 | Mangiferin prevents corticosterone-induced behavioural deficits via alleviation of oxido-nitrosative stress and down-regulation of indoleamine 2,3-dioxygenase (IDO) activity. ( Deng, WT; Gao, QW; Liu, L; Luo, GQ; Wu, XN; Xiang, W, 2017) |
"Administration of the acidic solution potentiated dentin hypersensitivity and increased corticosterone levels in the ED group compared with the WD group." | 3.85 | Depressive behavior induced by unpredictable chronic mild stress increases dentin hypersensitivity in rats. ( Barbosa, FM; Bonamin, LV; Bondan, EF; Cabral, D; de Fátima Monteiro Martins, M; Kabadayan, F; Kirsten, TB; Martha Bernardi, M; Queiroz-Hazarbassanov, N; Saraceni, CHC, 2017) |
"To further explore the underlying antidepressant mechanism of ginseng total saponins (GTS), this study observed the effects on hippocampal astrocyte structural plasticity and hippocampal volume in the corticosterone-induced mouse depression model." | 3.85 | Preventive Effects of Ginseng Total Saponins on Chronic Corticosterone-Induced Impairment in Astrocyte Structural Plasticity and Hippocampal Atrophy. ( Chen, L; Dai, JG; Huang, YF; Lin, ZX; Wang, X; Zhao, YN, 2017) |
"The benefits of creatine supplementation have been reported in a broad range of central nervous system diseases, including depression, although the mechanisms underlying these effects remain to be understood." | 3.85 | Creatine Prevents Corticosterone-Induced Reduction in Hippocampal Proliferation and Differentiation: Possible Implication for Its Antidepressant Effect. ( Azevedo, D; Brocardo, PS; Colla, A; Cunha, MP; de Oliveira, J; Gil-Mohapel, J; Pazini, FL; Ramos-Hryb, AB; Rodrigues, ALS; Rosa, JM, 2017) |
" We investigated whether neonatal blockade of the GABA-A receptors by bicuculline can alter anxiety- and depression-like behaviors, body weight, food intake, corticosterone and testosterone levels in adult mice (postnatal days 80-95)." | 3.85 | Neonatal blockade of GABA-A receptors alters behavioral and physiological phenotypes in adult mice. ( Amani, M; Salari, AA, 2017) |
"Agmatine, an endogenous neuromodulator, is a potential candidate to constitute an adjuvant/monotherapy for the management of depression." | 3.83 | Agmatine, by Improving Neuroplasticity Markers and Inducing Nrf2, Prevents Corticosterone-Induced Depressive-Like Behavior in Mice. ( Buendia, I; Casas, AI; Cuadrado, A; Egea, J; Freitas, AE; Gómez-Rangel, V; Lopez, MG; Navarro, E; Ortiz, JA; Parada, E; Rodrigues, ALS; Ruiz-Nuño, A; Wojnicz, A, 2016) |
"Ketamine has emerged as a novel strategy to treat refractory depression, producing rapid remission, but elicits some side effects that limit its use." | 3.83 | Creatine, Similar to Ketamine, Counteracts Depressive-Like Behavior Induced by Corticosterone via PI3K/Akt/mTOR Pathway. ( Colla, AR; Cunha, MP; Lieberknecht, V; Oliveira, Á; Pazini, FL; Rodrigues, AL; Rosa, JM, 2016) |
"Earlier, we reported that elevated anxiety-like behavior and high aggression in aged retired breeder Long-Evans (L-E) rats was associated with increased plasma corticosterone and elevated oxidative stress levels." | 3.83 | Tempol protects sleep-deprivation induced behavioral deficits in aggressive male Long-Evans rats. ( Asghar, S; Atrooz, F; Salim, S; Solanki, N, 2016) |
" Here we used a rodent model of anxiety/depression-like states, which is based on chronic CORT administration and studied the effects of the antidepressant fluoxetine (FLX) on behavior, olfaction, and adult neurogenesis in the dentate gyrus (DG), olfactory bulb (OB), and the olfactory epithelium (OE)." | 3.83 | Anxiety- and Depression-Like States Lead to Pronounced Olfactory Deficits and Impaired Adult Neurogenesis in Mice. ( de Chaumont, F; Denizet, M; Gabellec, MM; Guilloux, JP; Lazarini, F; Lledo, PM; Olivo-Marin, JC; Siopi, E, 2016) |
"Previously published reports have revealed the antidepressant-like effects of icariin in a chronic mild stress model of depression and in a social defeat stress model in mice." | 3.83 | Icariin reverses corticosterone-induced depression-like behavior, decrease in hippocampal brain-derived neurotrophic factor (BDNF) and metabolic network disturbances revealed by NMR-based metabonomics in rats. ( Gong, MJ; Han, B; Liang, SW; Wang, SM; Zou, ZJ, 2016) |
" In the current study the association between diurnal pattern of key phase markers (melatonin, corticosterone, and core body temperature) and anhedonic-like behavior was investigated using the highly validated rat chronic mild stress (CMS) model of depression." | 3.83 | Disturbed diurnal rhythm of three classical phase markers in the chronic mild stress rat model of depression. ( Bouzinova, EV; Christiansen, SL; Højgaard, K; Wiborg, O, 2016) |
" We used several well-validated animal models of depression to assess the antidepressant-like activity of LPM580153, followed by a neurotransmitter uptake assay and a corticosterone-induced cell injury model to explore its mechanism of action." | 3.83 | Antidepressant-like Effects of LPM580153, A Novel Potent Triple Reuptake Inhibitor. ( Liu, Q; Meng, X; Shao, J; Tian, J; Wang, H; Ye, L; Zhang, F; Zhong, Y, 2016) |
"The antidepressant-like effects of WGE and gastrodin might be mediated by the regulation of monoamine neurotransmitters, and therefore were beneficial in depression treatment as a complementary approach." | 3.83 | Antidepressant-like effects of water extract of Gastrodia elata Blume in rats exposed to unpredictable chronic mild stress via modulation of monoamine regulatory pathways. ( Chen, WC; Ho, CT; Lai, YS; Lin, SH; Lin, YE; Panyod, S; Sheen, LY, 2016) |
" Since the BDNF hypothesis of depression postulates that a reduction in BDNF is directly involved in the pathophysiology of depression, we evaluated the anti-depressive effects of HMF in mice with subcutaneously administered corticosterone at a dose of 20 mg/kg/day for 25 days." | 3.83 | 3,5,6,7,8,3',4'-Heptamethoxyflavone, a Citrus Flavonoid, Ameliorates Corticosterone-Induced Depression-like Behavior and Restores Brain-Derived Neurotrophic Factor Expression, Neurogenesis, and Neuroplasticity in the Hippocampus. ( Amakura, Y; Furukawa, Y; Nakajima, M; Okuyama, S; Sawamoto, A; Yamamoto, K; Yoshimura, M, 2016) |
"The corticosterone mouse model is widely used in preclinical research towards a better understanding of mechanisms of major depression." | 3.83 | Disruption of the HPA-axis through corticosterone-release pellets induces robust depressive-like behavior and reduced BDNF levels in mice. ( Albertini, G; Bentea, E; Demuyser, T; Deneyer, L; Massie, A; Smolders, I, 2016) |
"In order to relieve anxiety and depression accompanying stress, physicians resort to tricyclic antidepressants, such as imipramine." | 3.83 | Antidepressant imipramine diminishes stress-induced inflammation in the periphery and central nervous system and related anxiety- and depressive- like behaviors. ( Ramirez, K; Sheridan, JF, 2016) |
" We have made advantage of a model of depression based on tryptophan depletion in which we have previously demonstrated that the elevation of serum aldosterone precedes that of corticosterone." | 3.83 | Adipogenesis and aldosterone: a study in lean tryptophan-depleted rats. ( Csanova, A; Franklin, M; Hlavacova, N; Jezova, D; Pokusa, M; Zorad, S, 2016) |
" In vivo study, oral administration of these four CHMs for 14 days reversed the elevated plasma corticosterone levels, body weight loss, decrease in proliferation of hippocampal precursor cells; they also inhibited hippocampal cell apoptosis, and exhibited an antidepressant-like effect in a depression-like mouse model induced by CMS." | 3.83 | Chinese herbal medicines promote hippocampal neuroproliferation, reduce stress hormone levels, inhibit apoptosis, and improve behavior in chronically stressed mice. ( Chiou, SH; Hong, CJ; Lu, SW; Pao, LH; Shih, JH; Sun, GG, 2016) |
" In this study, we used the chronic corticosterone (CORT)-induced mouse model of anxiety/depression to assess antidepressant-like effects of baicalin and illuminate possible molecular mechanisms by which baicalin affects GR-mediated hippocampal neurogenesis." | 3.83 | Baicalin promotes hippocampal neurogenesis via SGK1- and FKBP5-mediated glucocorticoid receptor phosphorylation in a neuroendocrine mouse model of anxiety/depression. ( Dong, Y; Ma, J; Pan, X; Su, G; Wang, F; Wu, C; Yang, J; Zhang, K, 2016) |
" Here we investigate the short- and long-term effects of adolescent chronic mild stress (CMS) on the emergence of anxiety-/depressive-like behaviors (open-field and forced swim test - FST) and on HPA activity (corticosterone and type 1 CRH receptor - CRHR1) in PAE male and female rats." | 3.83 | Short- and long-term effects of stress during adolescence on emotionality and HPA function of animals exposed to alcohol prenatally. ( Chew, L; Ellis, L; Mok, P; Raineki, C; Weinberg, J, 2016) |
" We examined brain neuropeptide and glucocorticoid receptor (GR) expression, plasma corticosterone concentration rhythm and body temperature rhythm, together with depression- and anxiety-related behaviour." | 3.83 | Postnatal light alters hypothalamic-pituitary-adrenal axis function and induces a depressive-like phenotype in adult mice. ( Canal, MM; Coleman, G; Gigg, J, 2016) |
"It suggested that HCPE could improve the depression-like emotional status and associated cognitive deficits in CUMS rats, which might be mediated by regulation of neurotransmitters and BDNF levels in brain, alleviation of corticosterone level as well as the alleviation of oxidative stress." | 3.83 | Antidepressant-like effects and cognitive enhancement of the total phenols extract of Hemerocallis citrina Baroni in chronic unpredictable mild stress rats and its related mechanism. ( Aibai, S; Dong, LM; Le Zhai, J; Liao, YH; Liu, XM; Lu, C; Wang, KZ; Xu, P; Yang, Y, 2016) |
"The aim of the present study was to investigate the effects of the selective agonists of the corticotropin-releasing factor (CRF) 2 receptor, urocortin 2 (UCN 2) and urocortin 3 (UCN 3), on the anxiety- and depression-like signs induced by acute nicotine withdrawal in mice." | 3.83 | Selective CRF2 receptor agonists ameliorate the anxiety- and depression-like state developed during chronic nicotine treatment and consequent acute withdrawal in mice. ( Bagosi, Z; Balangó, B; Bokor, P; Buzás, A; Csabafi, K; Jászberényi, M; Palotai, M; Pintér, D; Simon, B; Szabó, G, 2016) |
" The trial's goal was to investigate the activity of Rip III in mice exposed to corticosterone-induced chronic depression model." | 3.81 | Subchronic administration of riparin III induces antidepressive-like effects and increases BDNF levels in the mouse hippocampus. ( Barbosa-Filho, JM; de França Fonteles, MM; de Sousa, FC; Gaspar, DM; Gutierrez, SJ; Oliveira, IC; Rodrigues, GC; Vasconcelos, AS; Vasconcelos, SM; Vidal, LT, 2015) |
" Here, we show that EE efficiently reduces anxiety and depression-like behaviors in a mouse model of depression induced by long-term administration of corticosterone." | 3.81 | Neurogenesis-independent antidepressant-like effects of enriched environment is dependent on adiponectin. ( Chabry, J; Gandin, C; Glaichenhaus, N; Heurteaux, C; Nicolas, S; Petit-Paitel, A; Pietri, M; Veyssière, J; Zsürger, N, 2015) |
" We found that chronic treatment of a mouse model of anxiety/depression (CORT model) with a selective serotonin reuptake inhibitor (SSRI, fluoxetine, 18mg/kg/day) reversed CORT-induced anxiety/depression-like behavior in mice." | 3.81 | Nrf2-signaling and BDNF: A new target for the antidepressant-like activity of chronic fluoxetine treatment in a mouse model of anxiety/depression. ( Ali, ZE; Damiens, MH; David, DJ; Gardier, AM; Kerdine-Römer, S; Mendez-David, I; Pallardy, M; Tritschler, L, 2015) |
" Hypericin (HY) is the main components in SJW extracts, which is used to treat fatigue, weakness, and mild depression." | 3.81 | LC-MS/MS based studies on the anti-depressant effect of hypericin in the chronic unpredictable mild stress rat model. ( Chen, C; Chen, F; Lu, YN; Zhai, XJ; Zhu, CR, 2015) |
"A mouse model of depression has been recently developed by exogenous corticosterone (CORT) administration, which has shown to mimic HPA-axis induced depression-like state in animals." | 3.81 | Resveratrol ameliorates depressive-like behavior in repeated corticosterone-induced depression in mice. ( Ali, SH; Bodduluru, LN; K V, A; Kasala, ER; Lahkar, M; Madhana, RM; Mahareddy, JR; Pitta, S, 2015) |
" We compared the effects of chronic treatment with the preferential nNOS inhibitor 7-nitroindazole (7-NI) with those evoked by the conventional antidepressant fluoxetine on alterations that are considered as markers of depression (immobility in the forced swimming test, FST, decreased body weight gain and increased plasma corticosterone concentration) and cardiovascular changes caused by CVS." | 3.81 | Effects of nitric oxide synthesis inhibitor or fluoxetine treatment on depression-like state and cardiovascular changes induced by chronic variable stress in rats. ( Almeida, J; Crestani, CC; Duarte, JO; Oliveira, LA, 2015) |
"Repeated injection of corticosterone (CORT) induces dysregulation in the hypothalamic-pituitary-adrenal (HPA) axis, resulting in depression." | 3.81 | Angelica gigas ameliorate depression-like symptoms in rats following chronic corticosterone injection. ( Hahm, DH; Lee, B; Lee, H; Shim, I; Sur, B, 2015) |
" In the present study, animals exposed to the chronic unpredictable stress (CUS), a rodent model of depression, exhibited elevated corticosterone, depressive-like behavior, memory deficits, accompanied with decreased cAMP-PKA-CREB and cAMP-ERK1/2-CREB signaling and neuroplasticity." | 3.81 | Phosphodiesterase-4D Knock-down in the Prefrontal Cortex Alleviates Chronic Unpredictable Stress-Induced Depressive-Like Behaviors and Memory Deficits in Mice. ( Li, YF; Liu, YQ; O'Donnell, JM; Wang, ZZ; Wilson, SP; Xu, Y; Yang, WX; Zhang, HT; Zhang, Y; Zhang, YZ; Zhao, N, 2015) |
" At 12 months, but not earlier, DEX-exposed mice displayed depression-like behavior and impaired hippocampal neurogenesis, not reversible by the antidepressant fluoxetine (FLX)." | 3.81 | Alterations in circadian entrainment precede the onset of depression-like behavior that does not respond to fluoxetine. ( Bose, R; Ceccatelli, S; Conti, M; DuPont, C; Onishchenko, N; Raciti, M; Spulber, S, 2015) |
"Corticosterone, one of the glucocorticoids, is toxic to neurons and plays an important role in depressive-like behavior and depression." | 3.81 | H2S protects PC12 cells against toxicity of corticosterone by modulation of BDNF-TrkB pathway. ( Gao, S; Gu, H; Li, W; Tang, X; Tian, Y; Xiao, F; Zhang, P; Zou, W, 2015) |
" This study was carried out in order to assess the influence of neonatal tactile stimulation (TS) on behavioral and morphological responses related to depression-like and anxiety-like behaviors, assessed following the administration of sertraline (SERT), a selective serotonin re-uptake inhibitor (SSRI)." | 3.81 | Neonatal tactile stimulation decreases depression-like and anxiety-like behaviors and potentiates sertraline action in young rats. ( Antoniazzi, CT; Barcelos, RC; Burger, ME; Duarte, MM; Duarte, T; Freitas, D; Metz, VG; Segat, HJ; Vey, LT, 2015) |
" Dependent measures included tests utilizing object recognition (OR), Y-maze, elevated plus maze (EPM), forced swim (FST), blood alcohol content, corticosterone levels, and body weights." | 3.80 | Female rats exposed to stress and alcohol show impaired memory and increased depressive-like behaviors. ( Gomez, JL; Luine, VN, 2014) |
"The aim of this study was to examine changes in rat emotional behavior and determine differences in the expression of GABA-A receptor alpha-2 subunits in brain structures of low- (LR) and high-anxiety (HR) rats after the repeated corticosterone administration." | 3.80 | The effect of chronic administration of corticosterone on anxiety- and depression-like behavior and the expression of GABA-A receptor alpha-2 subunits in brain structures of low- and high-anxiety rats. ( Krząścik, P; Lehner, M; Płaźnik, A; Skórzewska, A; Wisłowska-Stanek, A; Ziemba, A, 2014) |
"In this study, a mouse model of anxiety/depressant-like behavior induced by long-term corticosterone treatment was used to evaluate behavioral, endocrinal, and neurochemical changes in mice and their possible modulation of F-DPS treatment." | 3.80 | An organoselenium compound improves behavioral, endocrinal and neurochemical changes induced by corticosterone in mice. ( Bortolatto, CF; Duarte, MM; Gai, BM; Heck, SO; Nogueira, CW; Stein, AL; Zeni, G, 2014) |
" Herein, we have described a mouse model of a depression-like and insulin-resistant (DIR) state induced by the co-treatment of high-fat diet (HFD) and corticosterone (CORT)." | 3.80 | Depression-like behaviors in mice subjected to co-treatment of high-fat diet and corticosterone are ameliorated by AICAR and exercise. ( Ji, L; Li, H; Liu, W; Zhai, X, 2014) |
" We investigated for the first time whether neonatal exposure to TNF-α can affect body weight, stress-induced corticosterone (COR), anxiety- and depression-related behaviors in adult mice." | 3.80 | Tumor necrosis factor-alpha during neonatal brain development affects anxiety- and depression-related behaviors in adult male and female mice. ( Babri, S; Doosti, MH; Salari, AA, 2014) |
" Consistent with the anxiety profile, PDE4A KO mice had elevated corticosterone levels compared with wild-type controls post-stress." | 3.80 | Mice deficient in phosphodiesterase-4A display anxiogenic-like behavior. ( Conti, M; Hansen, RT; Zhang, HT, 2014) |
" Previous studies using preproenkephalin knockout (PENK KO) mice showed that these animals exhibit abnormal stress reactivity and show increased anxiety behavior in acute stress situations." | 3.80 | Enkephalin knockout male mice are resistant to chronic mild stress. ( Bilkei-Gorzo, A; Drews, E; Melo, I; Zimmer, A, 2014) |
" In this study, we investigated the antidepressant effect of GTS on the corticosterone-induced mouse depression model and explored the underlying mechanism." | 3.80 | The antidepressant effects of ginseng total saponins in male C57BL/6N mice by enhancing hippocampal inhibitory phosphorylation of GSK-3β. ( Chen, L; Dai, J; Huang, Y; Wang, Z; Zhang, H; Zhao, Y, 2014) |
"Female rats implanted with 28-day osmotic minipumps delivering the SSRI escitalopram throughout pregnancy had serum escitalopram concentrations in a clinically observed range (17-65 ng/ml)." | 3.79 | Prenatal exposure to escitalopram and/or stress in rats: a prenatal stress model of maternal depression and its treatment. ( Boss-Williams, KA; Bourke, CH; Capello, CF; Owens, MJ; Rogers, SM; Stowe, ZN; Weiss, JM; Yu, ML, 2013) |
"This study was designed to investigate the possible antidepressant effects of the antioxidant alpha-lipoic acid (ALA) as a stand-alone treatment or in association with desvenlafaxine (DVS) in the chronic corticosterone (CORT)-induced depression model." | 3.79 | Augmentation therapy with alpha-lipoic acid and desvenlafaxine: a future target for treatment of depression? ( Araújo, PV; da Silva, JC; de Oliveira, SL; de Sousa, CN; Macêdo, DS; Sampaio, LR; Silva, MC; Sousa, FC; Vasconcelos, SM; Ximenes, NC, 2013) |
"Ablation of olfactory bulbs caused depression-like symptoms as evidenced by increased immobility time in FST, hyperactivity in open field arena, and anhedonic like response in SPT along with alterations in mitochondrial enzyme complexes, increased serum corticosterone levels and oxidative damage." | 3.79 | Suppression of neuroinflammatory and apoptotic signaling cascade by curcumin alone and in combination with piperine in rat model of olfactory bulbectomy induced depression. ( Garg, S; Kumar, A; Rinwa, P, 2013) |
"To observe the effect of hesperidin on behavior and hypothalamic-pituitary-adrenal (HPA) axis of ratmodel of chronic stress-induced depression." | 3.79 | [Effect of hesperidin on behavior and HPA axis of rat model of chronic stress-induced depression]. ( Cai, L; Li, R; Wu, QQ; Wu, TN, 2013) |
" We sought to determine whether postnatal NMDA receptor blockade can affect normal development of body weight, corticosterone levels, anxiety- and depression-related behaviors in male and female mice in adulthood." | 3.79 | Neonatal NMDA receptor blockade alters anxiety- and depression-related behaviors in a sex-dependent manner in mice. ( Amani, M; Azarfarin, M; Bakhtiari, A; Doosti, MH; Majidi-Zolbanin, N; Mirza-Rahimi, M; Salari, AA; Samadi, H, 2013) |
" Moreover these rats exhibited anhedonia in a sucrose consumption test, and increased grooming in the open-field test, which reflects an anxiety-like condition." | 3.79 | Disruption of circadian rhythms due to chronic constant light leads to depressive and anxiety-like behaviors in the rat. ( Angeles-Castellanos, M; Escobar, C; Salgado-Delgado, R; Tapia-Osorio, A, 2013) |
"The antidepressant effect of a compound formed by co-ultramicronized palmitoylethanolamide (PEA) and luteolin (PEA+luteolin) was investigated in a mouse model of anxiety/depressive-like behavior." | 3.79 | Effects of palmitoylethanolamide and luteolin in an animal model of anxiety/depression. ( Ahmad, A; Campolo, M; Crupi, R; Cuzzocrea, S; Esposito, E; Paterniti, I, 2013) |
"This study is to investigate the amelioration effect of glucocorticoid receptor (GR) antagonist mifepristone on the changes of learning and memory abilities in rat model of depression." | 3.79 | [Mifepristone repairs alteration of learning and memory abilities in rat model of depression]. ( Chen, NH; Li, J; Liu, Y; Sun, JD; Yuan, YH, 2013) |
" At the end of the diet regimen, we assessed anxiety and depressive-like behaviour, corticosterone levels and biochemical changes in the midbrain and limbic brain regions." | 3.79 | Diet-induced obesity promotes depressive-like behaviour that is associated with neural adaptations in brain reward circuitry. ( Fulton, S; Sharma, S, 2013) |
" DHA deficiency during the preweaning period significantly increased and prolonged restraint stress-induced changes in colonic temperature and serum corticosterone levels, caused a significant increase in GABA(A) antagonist-induced heart rate changes and enhanced depressive-like behavior in the forced swimming test and anxiety-like behavior in the plus-maze test in later life." | 3.79 | Exposure to a maternal n-3 fatty acid-deficient diet during brain development provokes excessive hypothalamic-pituitary-adrenal axis responses to stress and behavioral indices of depression and anxiety in male rat offspring later in life. ( Chen, HF; Su, HM, 2013) |
" This study examined the effects of mGlu2/3 receptor antagonists in chronic corticosterone-treated mice which could be used as an animal model of depression." | 3.79 | Metabotropic glutamate 2/3 receptor antagonists improve behavioral and prefrontal dopaminergic alterations in the chronic corticosterone-induced depression model in mice. ( Ago, Y; Araki, R; Baba, A; Chaki, S; Hashimoto, H; Hiramatsu, N; Kawasaki, T; Kita, Y; Matsuda, T; Nakazato, A; Onoe, H; Takuma, K; Yano, K, 2013) |
"We investigated the effect of two well characterized preclinical animal models of depression - repeated injections of corticosterone (CORT) and repeated restraint stress - on markers of GABAergic and glutamatergic activity in the hippocampus and amygdala." | 3.79 | Altered GABAergic and glutamatergic activity within the rat hippocampus and amygdala in rats subjected to repeated corticosterone administration but not restraint stress. ( Caruncho, HJ; Kalynchuk, LE; Lussier, AL; Romay-Tallón, R, 2013) |
"Several clinical reports have postulated a beneficial effect of the addition of a low dose of risperidone to the ongoing treatment with antidepressants in treatment-resistant depression." | 3.78 | Effect of co-treatment with fluoxetine or mirtazapine and risperidone on the active behaviors and plasma corticosterone concentration in rats subjected to the forced swim test. ( Gądek-Michalska, A; Kabziński, M; Rachwalska, P; Rogóż, Z; Sadaj, W, 2012) |
" Behavioral responses associated with the CeA, such as anxiety, depression and fear memory, and the plasma corticosterone levels were evaluated under both basal and stressful conditions." | 3.78 | Site-specific genetic manipulation of amygdala corticotropin-releasing factor reveals its imperative role in mediating behavioral response to challenge. ( Chen, A; Gil, S; Regev, L; Tsoory, M, 2012) |
" We created an animal model of postpartum stress/depression based on administering high levels of corticosterone (CORT) to the dams during the postpartum period which caused behavioral changes and reduced hippocampal cell proliferation in the offspring." | 3.78 | Gestational and postpartum corticosterone exposure to the dam affects behavioral and endocrine outcome of the offspring in a sexually-dimorphic manner. ( Brummelte, S; Galea, LA; Lieblich, SE, 2012) |
" Aim of this paper was to study the relationship between neuroendocrine activation (circulating corticosterone and brain BDNF levels) and a wide array of depression- and anxiety-like behaviours (anhedonia, behavioural despair, generalised and social anxiety) resulting from exposure to chronic stress." | 3.78 | Social deprivation stress is a triggering factor for the emergence of anxiety- and depression-like behaviours and leads to reduced brain BDNF levels in C57BL/6J mice. ( Alleva, E; Bellisario, V; Berry, A; Calza, A; Capoccia, S; Cirulli, F; Tirassa, P, 2012) |
"Sub-chronic tryptophan depletion (SCTD) is proposed as an animal model for depression." | 3.78 | Sub-chronic dietary tryptophan depletion--an animal model of depression with improved face and good construct validity. ( Bermudez, I; Franklin, M; Gaburro, S; Murck, H; Singewald, N, 2012) |
" This study aimed to examine the antidepressant-like effect and the possible mechanisms of total glycosides of peony (TGP) in the CORT-induced depression model in rats." | 3.78 | Peony glycosides reverse the effects of corticosterone on behavior and brain BDNF expression in rats. ( Che, CT; Huang, Z; Ip, SP; Mao, QQ; Xian, YF, 2012) |
" In this study, we used the chronic mild stress (CMS) rat model of depression, which is based on continuous exposure to unpredictable stressors, to track longitudinal changes in HPA function using fecal corticosterone metabolites (FCM) as a read out." | 3.78 | Circadian activity of the hypothalamic-pituitary-adrenal axis is differentially affected in the rat chronic mild stress model of depression. ( Bouzinova, EV; Christiansen, S; Palme, R; Wiborg, O, 2012) |
"Both chronic mild stress and an injection of corticosterone induce depression-like states in rodents." | 3.78 | Corticosterone reduces brain mitochondrial function and expression of mitofusin, BDNF in depression-like rodents regardless of exercise preconditioning. ( Liu, W; Zhou, C, 2012) |
"On the basis of CMS-induced changes of sucrose intake, a reliable measure for anhedonia, rats were divided into "resilient" and "anhedonic" groups." | 3.78 | Chronic mild stress-induced depression-like symptoms in rats and abnormalities in catecholamine uptake in small arteries. ( Aalkjaer, C; Boedtkjer, DB; Bouzinova, EV; Broegger, T; Matchkov, VV; Møller-Nielsen, N; Wiborg, O, 2012) |
" In the present study, pain sensitivity was assessed in a mouse model of anxiety/depression on the basis of chronic corticosterone (CORT) administration through the drinking water (CORT model)." | 3.78 | Antinociceptive effects of fluoxetine in a mouse model of anxiety/depression. ( Coudoré, F; David, DJ; Gardier, AM; Guiard, BP; Hache, G; Le Dantec, Y; Orvoën, S, 2012) |
" Both the females that cohabited with the stressed males and those that cohabited with their male offspring showed behavioral (including anxiety- and depression-like behaviors), physiological (decreased body weight and basal corticosterone levels) and neurobiological symptoms (increased activity in dorsal raphe serotonergic neurons in response to an unfamiliar male) resembling the alterations described in abused and depressed women." | 3.78 | Evidence for biological roots in the transgenerational transmission of intimate partner violence. ( Ansermet, F; Cordero, MI; Fontana, X; Marquez, C; Poirier, GL; Salehi, B; Sandi, C; Veenit, V, 2012) |
") on the behavior, brain-derived neurotrophic factor (BDNF) and its receptor (TrkB) in depression-like rats induced by exogenous administration of the stress hormone corticosterone (40mg/kg, s." | 3.78 | Ethanol extracts from Hemerocallis citrina attenuate the decreases of brain-derived neurotrophic factor, TrkB levels in rat induced by corticosterone administration. ( Jiang, M; Li, HC; Li, J; Su, BF; Yang, KF; Yi, LT; Zhang, YT; Zhou, Y, 2012) |
" The oral administration of these three CHMs for 14 days reversed not only the elevation of plasma corticosterone levels and body weight loss, but also the decreasing of hippocampal precursor cell proliferation and abnormal behavior in the CMS induced depression-like mouse model." | 3.78 | Three Chinese herbal medicines promote neuroproliferation in vitro, and reverse the effects of chronic mild stress on behavior, the HPA axis, and proliferation of hippocampal precursor cell in vivo. ( Chiou, SH; Lu, SW; Ma, KH; Pao, LH; Sun, GG, 2012) |
"We examined a potential two-hit murine animal model of depression by assessing whether a genetic deficit in reelin increases vulnerability to the depressogenic effects of the stress hormone corticosterone." | 3.77 | Reelin as a putative vulnerability factor for depression: examining the depressogenic effects of repeated corticosterone in heterozygous reeler mice. ( Caruncho, HJ; Kalynchuk, LE; Lussier, AL; Romay-Tallón, R, 2011) |
" In controls, CUS resulted in the development of chronic stress state characterized by typical somatic (body weight reduction, thymus involution) and endocrine changes (resting plasma ACTH and corticosterone elevation and POMC mRNA elevation in anterior lobe of the pituitary)." | 3.77 | Lack of vasopressin does not prevent the behavioural and endocrine changes induced by chronic unpredictable stress. ( Bagdy, G; Barna, I; Domokos, A; Jankord, R; Varga, J; Zelena, D, 2011) |
" Subordinate 129SvEv mice showed body weight gain, hyperphagia, increased adipose fat pads weight and basal plasma corticosterone." | 3.77 | Vulnerability to chronic subordination stress-induced depression-like disorders in adult 129SvEv male mice. ( Bartolomucci, A; Ceresini, G; Dadomo, H; Di Cristo, L; Lori, A; Malinge, I; Palanza, P; Parmigiani, S; Sanghez, V; Sheardown, M, 2011) |
" Behavior in the elevated plus maze (EPM; anxiety) and forced swimming test (FST; depression) as well as adrenocorticotropin and corticosterone hormone levels were measured at postpartum days 23-25 and at adult age." | 3.77 | Changes in adaptability following perinatal morphine exposure in juvenile and adult rats. ( Fürst, Z; Gyarmati, Z; Klausz, B; Pintér, O; Sobor, M; Tímár, J; Zelena, D, 2011) |
" The present study was designed to investigate the effect of Hypericum perforatum treatment in a mouse model of anxiety/depressive-like behavior, induced by chronic corticosterone administration." | 3.77 | Hypericum perforatum treatment: effect on behaviour and neurogenesis in a chronic stress model in mice. ( Battaglia, F; Bramanti, P; Crupi, R; Cuzzocrea, S; La Spada, G; Marino, A; Mazzon, E; Spina, E, 2011) |
"A rat model of depression has been recently developed using exogenous corticosterone (CORT) administration." | 3.77 | Curcumin reverses corticosterone-induced depressive-like behavior and decrease in brain BDNF levels in rats. ( Feng, CR; Huang, Z; Li, ZY; Mao, QQ; Pan, AJ; Zhong, XM, 2011) |
" In this study, the adult male offspring of dams exposed to restraint stress during the last semester of pregnancy and fed different diets were evaluated for depressive-like behavior in the forced swimming test and for the corticosterone response to the test." | 3.77 | Effect of fish oil and coconut fat supplementation on depressive-type behavior and corticosterone levels of prenatally stressed male rats. ( Borsonelo, EC; Galduróz, JC; Suchecki, D, 2011) |
" When the animals reached adulthood, the groups were subdivided and the rats were submitted or not to CVS, which consisted of daily exposure to different stressors for 40 days, followed by a period of behavioral tasks, biochemical (plasma corticosterone and insulin sensitivity) and neurochemical (Na⁺,K⁺-ATPase activity in hippocampus, amygdala and parietal cortex) measurements." | 3.77 | Association between Na⁺,K⁺-ATPase activity and the vulnerability/resilience to mood disorders induced by early life experience. ( Benetti, Cda S; Dalmaz, C; Lucion, AB; Mattos, CB; Portella, AK; Scherer, EB; Silveira, PP; Wyse, AT; Zugno, AI, 2011) |
"In this study, we find that ICS exposure causes a transient increase in plasma corticosterone concentration, but not in anxiety or depression-like behaviors." | 3.77 | Permanent relief from intermittent cold stress-induced fibromyalgia-like abnormal pain by repeated intrathecal administration of antidepressants. ( Araki, K; Kishioka, S; Mukae, T; Nagai, J; Nishiyori, M; Uchida, H; Ueda, H, 2011) |
"The authors examined whether the spared nerve injury model of neuropathic pain induces depressive behavior in rats, using sucrose preference test and forced swim test, and tested whether a subanesthetic dose of ketamine treats spared nerve injury-induced depression." | 3.77 | A single subanesthetic dose of ketamine relieves depression-like behaviors induced by neuropathic pain in rats. ( Blanck, TJ; Eberle, SE; Goffer, Y; Shamir, DB; Tukey, DS; Wang, J; Xu, D; Ziff, EB; Zou, AH, 2011) |
" Our study showed that stress reduced body weight, decreased sucrose intake and sucrose preference, and increased immobility in a forced swimming test." | 3.77 | Exposure to enriched environment restores the mRNA expression of mineralocorticoid and glucocorticoid receptors in the hippocampus and ameliorates depressive-like symptoms in chronically stressed rats. ( Liu, H; Sun, H; Yang, Y; Yao, Z; Zhang, J; Zhang, L, 2011) |
" Experiment 2 showed that fluoxetine treatment administered via drinking water attenuated depressive-like behaviour in the FST and TST in individually housed female C57BL/6J mice, but had no effect on anxiety-like behaviour." | 3.76 | The lonely mouse: verification of a separation-induced model of depression in female mice. ( Brown, RE; Martin, AL, 2010) |
"Neonatal treatment with clomipramine (CMI) in rats induces multiple behavioral alterations during adulthood that resemble certain symptoms of human depression, such as impairments of pleasure-seeking behaviors." | 3.76 | Circadian activity of corticosterone in an animal model of depression: response to muscarinic cholinergic stimulation. ( Arteaga-Silva, M; Bonilla-Jaime, H; Hernández-González, M; Retana-Márquez, S; Vázquez-Palacios, G, 2010) |
" These indices were depression-like behavior (increased immobility time in the forced-swim test) and acute restraint stress-induced changes in hypothalamo-pituitary-adrenocortical (HPA) axis activity [plasma corticosterone (CORT) and ACTH levels and the number of Fos-immunoreactive cells in the hypothalamic paraventricular nucleus (an index of neuronal activity)]." | 3.76 | "Green odor" inhalation by stressed rat dams reduces behavioral and neuroendocrine signs of prenatal stress in the offspring. ( Fujita, S; Miyoshi, M; Ueki, S; Watanabe, T, 2010) |
" Prolonged elevated levels of glucocorticoids are associated with depression and we developed an animal model of postpartum depression/stress based on high levels of corticosterone (CORT) during the postpartum." | 3.76 | Chronic corticosterone during pregnancy and postpartum affects maternal care, cell proliferation and depressive-like behavior in the dam. ( Brummelte, S; Galea, LA, 2010) |
"We studied the early and delayed effects of hypoxia during the infantile period on the behavioral reactions and corticosterone concentration in male rats." | 3.76 | Early and delayed effects of hypoxia during the infantile period on behavioral and hormonal reactions of rats. ( Bagaeva, TR; Butkevich, IP; Makukhina, GV; Mikhailenko, VA; Otellin, VA, 2010) |
"We have recently shown that repeated high dose injections of corticosterone (CORT) reliably increase depression-like behavior on a modified one-day version of the forced swim test." | 3.75 | Repeated exposure to corticosterone increases depression-like behavior in two different versions of the forced swim test without altering nonspecific locomotor activity or muscle strength. ( Fournier, NM; Kalynchuk, LE; Marks, W, 2009) |
"Repeated injection of corticosterone (CORT) induces dysregulation in the HPA axis, resulting in depression and anxiety." | 3.75 | Effects of acupuncture on chronic corticosterone-induced depression-like behavior and expression of neuropeptide Y in the rats. ( Hahm, DH; Lee, B; Lee, HJ; Shim, I; Yang, Y, 2009) |
" The atypical antipsychotic risperidone and the selective serotonin (5-HT)(2) antagonist ritanserin normalized the depression-like behavior in PACAP-/- mice." | 3.75 | Depression-like behavior in the forced swimming test in PACAP-deficient mice: amelioration by the atypical antipsychotic risperidone. ( Baba, A; Guo, X; Hashimoto, H; Hashimoto, R; Hatanaka, M; Morita, Y; Nagai, K; Shintani, N; Takeda, M; Tanaka, K; Tanida, M; Yamamoto, A, 2009) |
" Here we describe a mouse model of an anxiety/depressive-like state induced by chronic corticosterone treatment." | 3.75 | Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression. ( Antonijevic, IA; Artymyshyn, RP; Craig, DA; David, DJ; Drew, M; Gardier, AM; Gerald, C; Guiard, BP; Guilloux, JP; Hen, R; Leonardo, ED; Marsteller, D; Mendez, I; Rainer, Q; Samuels, BA; Wang, JW, 2009) |
" The aim of this study was to determine short- and long-term effects of early postnatal hypoxia (on day 7) on depression- and pain-related behaviors and the plasma corticosterone levels." | 3.75 | Short- and long-term influences of hypoxia during early postnatal period of development on behavioral and hormonal responses in rats. ( Bagaeva, TR; Butkevich, IP; Makukhina, GV; Mikhailenko, VA; Otellin, VA, 2009) |
" psychological (social defeat) stressors on anxiety- and depression-related behaviors, serum levels of corticosterone and the expression of plasticity-related genes CAM-L1, CREB, GAP-43, and laminin in the prefrontal cortex (PFC), the amygdala and the hippocampus." | 3.75 | Physical stress differs from psychosocial stress in the pattern and time-course of behavioral responses, serum corticosterone and expression of plasticity-related genes in the rat. ( Ben-Shachar, D; Kavushansky, A; Klein, E; Richter-Levin, G, 2009) |
" However, LPS-induced fever, rises in plasma corticosterone, body weight loss and c-Fos expression in the hypothalamus and caudal brainstem were not altered by i." | 3.74 | Central nervous action of interleukin-1 mediates activation of limbic structures and behavioural depression in response to peripheral administration of bacterial lipopolysaccharide. ( Combe, C; Dantzer, R; Konsman, JP; Luheshi, GN; Poole, S; Veeneman, J, 2008) |
"In controls, chronic mild stress resulted in symptoms of chronic stress state characterized by typical somatic (body weight reduction, thymus involution) and endocrine changes (resting plasma ACTH and corticosterone elevation and POMC mRNA elevation in anterior lobe of the pituitary)." | 3.74 | The role of vasopressin in chronic stress studied in a chronic mild stress model of depression. ( Bagdy, G; Barna, I; Csabail, K; Domokos, A; Makara, GB; Zelena, D, 2007) |
"Cholecystokinin (CCK) involvement in depression-like disorders is poorly documented." | 3.74 | Repeated social defeat-induced depression-like behavioral and biological alterations in rats: involvement of cholecystokinin. ( Becker, C; Benoliel, JJ; Blugeot, A; Hamon, M; Rivat, C; Zeau, B, 2008) |
"Chronic corticosterone injections induce hippocampus tissue damage and depression-like behavior in rodent animals, the cause of which is not known." | 3.74 | Chronic corticosterone injections induce a decrease of ATP levels and sustained activation of AMP-activated protein kinase in hippocampal tissues of male mice. ( Du, L; Li, B; Shen, J; Su, H; Xing, D; Zhao, Y, 2008) |
"A rat model of depression has been recently developed by exogenous corticosterone administration." | 3.74 | A mouse model of depression induced by repeated corticosterone injections. ( Du, L; Ma, R; Shen, J; Su, H; Xing, D; Zhao, Y, 2008) |
"A dysregulated hypothalamic-pituitary-adrenal axis (HPA) has been implicated in major depressive disorder and most commonly used animal models of depression have been shown to elevate circulating levels of plasma corticosterone." | 3.74 | Chronic low dose corticosterone exposure decreased hippocampal cell proliferation, volume and induced anxiety and depression like behaviours in mice. ( Hutson, PH; Murray, F; Smith, DW, 2008) |
"We investigated the influence of tiagabine on stress hormone release, cellular immune function and behaviour in rats following olfactory bulbectomy (OB), a well-recognized animal model of depression." | 3.74 | Tiagabine treatment is associated with neurochemical, immune and behavioural alterations in the olfactory bulbectomized rat model of depression. ( Dostalek, M; Jezova, D; Pistovcakova, J; Sulcova, A, 2008) |
" The purpose of the present study was to characterize the effect of repeated corticosterone (CORT) injections and repeated restraint stress on anxiety and depression-like behavior in male rats." | 3.73 | Effect of repeated corticosterone injections and restraint stress on anxiety and depression-like behavior in male rats. ( Davis, AC; Gregus, A; Kalynchuk, LE; Wintink, AJ, 2005) |
"Administration of amphetamine (AMPH) can induce symptoms of psychosis in humans and locomotor sensitization in rats; in contrast, withdrawal from a period of AMPH intake is most often associated with symptoms of human endogenous depression." | 3.72 | Amphetamine withdrawal does not produce a depressive-like state in rats as measured by three behavioral tests. ( Feldon, J; Murphy, CA; Nanz-Bahr, NI; Pezze, MA; Pryce, CR; Russig, H, 2003) |
"Topiramate is currently used in the treatment of epilepsy, but this anticonvulsant drug has also been reported to exert mood-stabilizing effects and induce weight loss in patients." | 3.72 | Topiramate normalizes hippocampal NPY-LI in flinders sensitive line 'depressed' rats and upregulates NPY, galanin, and CRH-LI in the hypothalamus: implications for mood-stabilizing and weight loss-inducing effects. ( Bolwig, G; Husum, H; Mathé, A; Termeer, E; Van Kammen, D, 2003) |
"The humoral response and the role of catecholamines and corticosterone were analyzed in a chronic mild stress (CMS) model of depression." | 3.72 | Impaired T-cell dependent humoral response and its relationship with T lymphocyte sensitivity to stress hormones in a chronic mild stress model of depression. ( Ayelli-Edgar, V; Genaro, AM; Silberman, DM; Zieher, LM; Zorrilla-Zubilete, M, 2004) |
"Behaviors reflecting anhedonia and/or anorexia, sickness behavior, plasma corticosterone and norepinephrine (NE) activity in the paraventricular nucleus (PVN) of the hypothalamus were assessed following continuous infusion of IL-2 over 7 days in CD-1 mice." | 3.72 | Influence of chronic interleukin-2 infusion and stressors on sickness behaviors and neurochemical change in mice. ( Anisman, H; Hayley, S; Sudom, K; Turrin, NP, 2004) |
"This experiment examined the effect of repeated corticosterone injections on anxiety and depression-like behavior in male and female rats." | 3.72 | Corticosterone increases depression-like behavior, with some effects on predator odor-induced defensive behavior, in male and female rats. ( Boudreau, D; Gregus, A; Kalynchuk, LE; Perrot-Sinal, TS, 2004) |
" These long-term neuroendocrinological effects are mediated, at least in part, by stress-induced maternal corticosterone increase during pregnancy and stress-induced maternal anxiety during the postnatal period." | 3.71 | Hormonal and behavioural abnormalities induced by stress in utero: an animal model for depression. ( Darnaudery, M; Maccari, S; Van Reeth, O, 2001) |
"The effects of chronic corticosterone treatment (100 mg pellet implanted for 1 week) were assessed in animal tests of anxiety, exploration and motor activity, and changes in binding to 5-HT1A and 5-HT2A receptors, and the 5-HT transporter, were measured." | 3.69 | Decreased 5-HT1A and increased 5-HT2A receptor binding after chronic corticosterone associated with a behavioural indication of depression but not anxiety. ( Fernandes, C; File, SE; McEwen, BS; McKittrick, CR, 1997) |
" The degree of anorexia and plasma corticosterone elevation in response to the stress was measured." | 3.67 | The effect of acute and chronic administration of desmethylimipramine on responses to stress in rats. ( Platt, JE; Stone, EA; Trullas, R, 1984) |
"The enhanced inflammation and hypercortisolism that typically characterize stress-related illnesses, such as depression, metabolic syndrome, cardiovascular disease, or osteoporosis, may also be related to increased glucocorticoid resistance." | 2.48 | Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction. ( Silverman, MN; Sternberg, EM, 2012) |
"Depression is one of the most common mood disturbances worldwide." | 1.91 | SNS alleviates depression-like behaviors in CUMS mice by regluating dendritic spines via NCOA4-mediated ferritinophagy. ( Ao, HQ; Chen, WC; Chen, WG; He, CY; He, SQ; Li, T; Lin, HS; Liu, Y; Song, ML; Sun, HT; Yang, XM; Zhang, MJ; Zhang, Y; Zhong, XD, 2023) |
"Quercetin is a flavonoid compound, which has anti-inflammatory and antioxidant roles." | 1.91 | Quercetin mitigates depression-like behavior via the suppression of neuroinflammation and oxidative damage in corticosterone-induced mice. ( Ge, C; Lei, L; Wang, S; Wu, X, 2023) |
"Depression is a common psychiatric disorder affecting around 300 million people worldwide." | 1.91 | Emotional behaviors as well as the hippocampal reelin expression in C57BL/6N male mice chronically treated with corticosterone. ( Hiramatsu, M; Ibi, D; Kinoshita, M; Nakasai, G; Sawahata, M; Takaba, R; Yamada, K, 2023) |
"Anxious depression is a prevalent disease with devastating consequences." | 1.91 | Social avoidance and altered hypothalamic-pituitary-adrenal axis in a mouse model of anxious depression: The role of LPA ( Estivill-Torrús, G; Gómez-Salas, FJ; Moreno-Fernández, RD; Nieto-Quero, A; Pedraza, C; Rodríguez de Fonseca, F; Sampedro-Piquero, P; Santín, LJ, 2023) |
"anxiety and depression) are commonly observed in patients with epilepsy and induce seizure aggravation." | 1.72 | Transcranial Direct Current Stimulation Reduces Anxiety, Depression and Plasmatic Corticosterone in a Rat Model of Atypical Generalized Epilepsy. ( Antunes, GF; Castro, MC; Germann, J; Gomes, GCV; Gouveia, FV; Martinez, RCR; Oliveira, CC; Pinto, TRC; Valle, AC, 2022) |
"The success rate of the chronic pain-depression (CPD) model was 62." | 1.72 | A New Potential Antidepressant: Dexmedetomidine Alleviates Neuropathic Pain-Induced Depression by Increasing Neurogenesis in the Hippocampus. ( He, M; Xu, S; Zhang, X; Zhao, X; Zheng, X; Zhu, Z, 2022) |
"Major depression is a leading contributor to the global burden of disease." | 1.72 | Lower antidepressant response to fluoxetine is associated with anxiety-like behavior, hippocampal oxidative imbalance, and increase on peripheral IL-17 and IFN-γ levels. ( Becker, G; Bochi, GV; Camargo, LFM; da Silva Carlotto, M; Dos Santos, BM; Fialho, MFP; Oliveira, SM; Pereira, GC; Pillat, MM; Piton, E; Ramanzini, LG; Trevisan, G; Zanchet, EM, 2022) |
"Depression is a global health problem, and there is a pressing need for a better understanding of its pathogenesis." | 1.72 | Hippocampal semaphorin 3B improves depression-like behaviours in mice by upregulating synaptic plasticity and inhibiting neuronal apoptosis. ( Du, Y; Gao, Y; Gong, M; Guo, X; Hao, Y; Shi, H; Shi, M; Shi, Y; Song, H; Song, L; Wang, S; Wang, X; Zhao, Y, 2022) |
"Pregnancy is a very complex and highly stressful time in which women become more physically and emotionally vulnerable." | 1.72 | Swimming exercise strain-dependently affects maternal care and depression-related behaviors through gestational corticosterone and brain serotonin in postpartum dams. ( Ebrahimian, F; Masrour, FF; Najdi, N; Salari, AA, 2022) |
"Intestinal dysbacteriosis is associated with depression." | 1.72 | Antibiotics-induced depression in mice via the microbiota-gut-brain axis. ( Deng, H; Fan, X; Ji, H; Qiu, J; Shen, X, 2022) |
"Depression has become an important disease threatening human health." | 1.72 | Mahonia Alkaloids (MA) Ameliorate Depression Induced Gap Junction Dysfunction by miR-205/Cx43 Axis. ( Chen, N; Chu, S; He, F; He, J; Lai, K; Li, D; Li, Y; Wang, S; Wei, D; Wei, G; Wei, J; Xie, J; Zhang, Z, 2022) |
"Depression is positively correlated with the high incidence and low survival rate of cancers, while more cancer patients suffer depression." | 1.72 | The combination of chronic stress and smoke exacerbated depression-like changes and lung cancer factor expression in A/J mice: Involve inflammation and BDNF dysfunction. ( Li, KW; Liu, BP; Song, C; Zhang, C; Zhang, YP, 2022) |
"Depression is a very common mental disorder and mechanism that is associated with mitochondrial dysfunction." | 1.72 | Antidepressant-Like Effects of Edaravone and Minocycline: Investigation of Oxidative Stress, Neuroinflammation, Neurotrophic, and Apoptotic Pathways. ( Bagheri, A; Motafeghi, F; Seyedabadi, M; Shaki, F; Shokrzadeh, M, 2022) |
"Depression is a psychiatric disorder leading to anhedonia and lack of interest and motivation." | 1.72 | Antidepressive-Like Effect of ( Alhalmi, A; Kumar, G; Pathak, D; Sharma, A; Singh, T; Virmani, T, 2022) |
"Depression is a common, chronic, and often recurrent serious mood disorder." | 1.72 | Neuroprotective and Antioxidant Effects of Riparin I in a Model of Depression Induced by Corticosterone in Female Mice. ( Adelvane de Paula Rodrigues, F; Barbosa-Filho, JM; Cavalcanti Capibaribe, VC; Chavez Gutierrez, SJ; de Castro Chaves, R; Ferreira de Oliveira, N; Florenço de Sousa, FC; Lopes Sales, IS; Maia Oliveira, IC; Maria de França Fonteles, M; Rodrigues de Carvalho, AM; Rodrigues, GC; Teodorio Vidal, LM; Vasconcelos Mallmann, AS, 2022) |
"Rats with recurrent depression are highly susceptible to stress and exhibit depression-like behaviours such as weight loss, increased immobility time in tail suspension test, and reduced sucrose preference index." | 1.62 | Behavioral and Neurochemical Changes in Rats with Recurrent Depression induced by chronic unpredictable stress. ( Chen, L; Hong, C; Huang, Z; Kong, W; Qiu, F; Wang, L; Zhang, D; Zhang, G; Zhao, J; Zhong, X, 2021) |
"Corticosterone (CORT) treatment significantly enhanced Bag-1/GR complex formation and GR mitochondrial translocation in cultured rat cortical neurons after treatment for 30 min and 24 hr." | 1.62 | Bag-1 mediates glucocorticoid receptor trafficking to mitochondria after corticosterone stimulation: Potential role in regulating affective resilience. ( Bao, H; Du, J; Feng, L; Hou, Y; Hunter, RG; Jia, Y; K Manji, H; Li, H; Luo, S; S McEwen, B; Wang, G; Xiao, C; Yuan, P; Zhang, Y, 2021) |
"Major depressive disorder is a common debilitating mental health problem that represents one of the leading causes of disability." | 1.62 | Adult neurogenesis augmentation attenuates anhedonia and HPA axis dysregulation in a mouse model of chronic stress and depression. ( Belzung, C; Brizard, B; Eliwa, H; Hen, R; Le Guisquet, AM; Surget, A, 2021) |
"Depression is a pervasive or persistent mental disorder that causes mood, cognitive and memory deficits." | 1.62 | Uncaria rhynchophylla ameliorates unpredictable chronic mild stress-induced depression in mice via activating 5-HT ( Dai, SF; Deng, XP; Huang, HL; Li, S; Liang, JH; Liu, CQ; Luan, ZL; Ma, XC; Qiao, YL; Sun, CP; Yu, ZL; Zhang, ZJ; Zhou, JJ, 2021) |
"Depression is a psychiatric disorder with several comorbidities that has a complicated pathophysiology." | 1.62 | Exercise and fluoxetine treatment during adolescence protect against early life stress-induced behavioral abnormalities in adult rats. ( Amiri, S; Gauvin, E; Peeri, M; Pirri, F; Zolfaghari, FS, 2021) |
"Depression was induced by 14 days of chronic restraint stress (CRS) daily for 4 h." | 1.62 | Therapeutic Potential of Curcumin in Reversing the Depression and Associated Pseudodementia via Modulating Stress Hormone, Hippocampal Neurotransmitters, and BDNF Levels in Rats. ( Afzal, A; Ahmad, S; Batool, Z; Haider, S; Kamil, N; Liaquat, L; Perveen, T; Sadir, S; Shahzad, S; Tabassum, S, 2021) |
"Though the association between overactive bladder (OAB) and depression was noticed years ago, the pharmaceutical market does not offer one universal drug that would cure both conditions at the same time." | 1.56 | Duloxetine reverses the symptoms of overactive bladder co-existing with depression via the central pathways. ( Kociszewski, J; Poleszak, E; Serefko, A; Szopa, A; Wiśniewski, R; Woźniak, A; Wróbel, A, 2020) |
" For this purpose, different animal models are used to study routes and molecular changes involved in depression, among them the chronic administration of corticosterone." | 1.56 | Glucocorticoid and brain-derived neurotrophic factor relationship: a brief investigation into the model of depression by chronic administration of corticosterone. ( Bochi, GV; Burger, ME; Pereira, GC; Roversi, K; Trevisan, G, 2020) |
"Corticosterone plasma level was increased in the CUMS compared to the non-stressed group (p < 0." | 1.56 | Valproic acid administration exerts protective effects against stress-related anhedonia in rats. ( Barati, M; Eslami, M; Goudarzi, M; Mehrabi, S; Nahavandi, A; Shahbazi, A, 2020) |
"Corticosterone treatment induced depression-like behaviors, it increased immobility time in the TST, OFT, and FST, decreased the number of movements in OFT, and decreased sucrose consumption." | 1.56 | Oleuropein Reverses Repeated Corticosterone-Induced Depressive-Like Behavior in mice: Evidence of Modulating Effect on Biogenic Amines. ( Al-Rasheed, N; Attia, HA; Badr, AM, 2020) |
" Based on these findings, this study aimed to investigate the possible effects of Riparin IV (Rip IV) on cognitive impairment induced by chronic administration of corticosterone in mice." | 1.56 | The neuroprotective effect of Riparin IV on oxidative stress and neuroinflammation related to chronic stress-induced cognitive impairment. ( Barbosa Filho, JM; Barbosa, GR; Capibaribe, VCC; Chaves, RC; da Silva, DMA; de Carvalho, AMR; de Oliveira, NF; de Sousa, FCF; Fonteles, MMF; Gutierrez, SJC; Lopes, IS; Mallmann, ASV; Valentim, JT, 2020) |
"Depression is one of the most common mood disorders, which affects one in six people at some point in life." | 1.56 | Apocynin as an antidepressant agent: in vivo behavior and oxidative parameters modulation. ( Bochi, GV; da Silva, RM; Dalenogare, DP; de Almeida, AS; Dos Santos, BM; Dos Santos, GT; Fialho, MFP; Marchesan, S; Moresco, RN; Pereira, GC; Piton, E; Schiefelbein, NS, 2020) |
"Hair corticosterone was also assayed by liquid chromatography-mass spectrometry." | 1.56 | Effects of Chronic Cannabidiol Treatment in the Rat Chronic Unpredictable Mild Stress Model of Depression. ( Albert, Á; Farkas, S; Ferencz, E; Gáll, Z; Kolcsár, M; Urkon, M; Vancea, S, 2020) |
" Therefore, the current study investigates the effects of chronic administration of the commercially available probiotic Bifidobacterium longum subsp." | 1.56 | Probiotic treatment (Bifidobacterium longum subsp. longum 35624™) affects stress responsivity in male rats after chronic corticosterone exposure. ( Brummelte, S; Haas, GS; Mooney-Leber, SM; Saffar, M; Wang, W, 2020) |
"Caffeine has been known to combat stress-evoked depression." | 1.56 | New insights into the effects of caffeine on adult hippocampal neurogenesis in stressed mice: Inhibition of CORT-induced microglia activation. ( He, RR; Kurihara, H; Li, WX; Li, YF; Luo, Z; Mao, ZF; Ouyang, SH; Tu, LF; Wang, GE; Wu, YP; Zhang, QY, 2020) |
"Depression is recognized as a highly chronic and recurrent disorder." | 1.56 | Cyclical administration of corticosterone results in aggravation of depression-like behaviors and accompanying downregulations in reelin in an animal model of chronic stress relevant to human recurrent depression. ( Allen, J; Caruncho, HJ; Kalynchuk, LE; Kulhawy, EY; Lebedeva, KA, 2020) |
"The studies aimed to determine the antidepressant efficacy of single and chronic administration of dapoxetine alone and vortioxetine alone, as well as in the combination of these drugs." | 1.56 | Antistress and antidepressant properties of dapoxetine and vortioxetine. ( Kopciuch, D; Kus, K; Nowakowska, E; Paczkowska, A; Ratajczak, P; Skórczewska, B; Zaprutko, T; Zielińska-Przyjemska, M, 2020) |
"Depression is closely linked to hypothalamus-pituitary-adrenal axis hyperactivity." | 1.56 | Antidepressant-like mechanism of honokiol in a rodent model of corticosterone-induced depression. ( Chang, HS; Duan, XH; Hu, KL; Li, LN; Li, Y; Liu, M; Yu, X; Zhang, B, 2020) |
"All strains variously developed mechanical allodynia after SNI with the exception of stress-hyporesponsive LEW rats, despite all strains displaying similar functional gait-deficits after injury." | 1.56 | The influence of rat strain on the development of neuropathic pain and comorbid anxio-depressive behaviour after nerve injury. ( Abelson, KSP; Andersson, DR; Brønnum Pedersen, T; Finn, DP; Hestehave, S; Munro, G, 2020) |
"2-Phenethylamine (PEA) is a monoamine alkaloid that acts as a central nervous system stimulant in humans." | 1.56 | 2-Phenylethylamine (PEA) Ameliorates Corticosterone-Induced Depression-Like Phenotype via the BDNF/TrkB/CREB Signaling Pathway. ( Hwang, DY; Hyun, SA; Ka, M; Kim, HR; Ko, MY; Lee, BS; Lee, CY; Lee, YJ, 2020) |
"Depression is the leading cause of mental health-related disease globally, and it affects an estimated 300 million people worldwide." | 1.51 | Antidepressant activity of crocin-I is associated with amelioration of neuroinflammation and attenuates oxidative damage induced by corticosterone in mice. ( Fu, Z; Shen, Q; Wang, L; Xiao, Q; Xie, X; Xiong, Z; Yu, C; Zhou, J, 2019) |
" RESULTS The results showed that the extract at the dosage of 50 and 100 mg/kg significantly (p<0." | 1.51 | Antidepressive Effects of Taraxacum Officinale in a Mouse Model of Depression Are Due to Inhibition of Corticosterone Levels and Modulation of Mitogen-Activated Protein Kinase Phosphatase-1 (Mkp-1) and Brain-Derived Neurotrophic Factor (Bdnf) Expression. ( Duan, H; Gao, C; Guo, B; Kong, S; Li, D; Liang, X, 2019) |
"Treatment with crocin, exposure to wheel running activity, and the combined interventions alleviated both behavioral and morphological deficits induced by adolescent stress." | 1.51 | Beneficial Effects of Physical Activity and Crocin Against Adolescent Stress Induced Anxiety or Depressive-Like Symptoms and Dendritic Morphology Remodeling in Prefrontal Cortex in Adult Male Rats. ( Ghalandari-Shamami, M; Nourizade, S; Pakdel, R; Rashidy-Pour, A; Vafaei, AA; Yousefi, B, 2019) |
"Depression is a common psychiatric disease which pharmacological treatment relieves symptoms, but still far from ideal." | 1.51 | Tactile Stimulation on Adulthood Modifies the HPA Axis, Neurotrophic Factors, and GFAP Signaling Reverting Depression-Like Behavior in Female Rats. ( Burger, ME; de David Antoniazzi, CT; Duarte, MM; Duarte, T; Kronbauer, M; Milanesi, LH; Rosa, HZ; Rossato, DR; Roversi, K, 2019) |
"Depression is a neuropsychiatry medical condition with high prevalence, in which the hypothalamic-pituitary-adrenal axis dysfunction has been postulated as the main cause." | 1.51 | Lutein prevents corticosterone-induced depressive-like behavior in mice with the involvement of antioxidant and neuroprotective activities. ( Camargo, A; Dalmagro, AP; Zeni, ALB, 2019) |
"Corticosterone (CORT) has long been shown to modulate 5-HT system, and to alter hippocampal functions in various physiological and pathological conditions." | 1.51 | Acute corticosterone treatment elicits antidepressant-like actions on the hippocampal 5-HT and the immobility phenotype. ( He, T; Li, L; Li, X; Li, Y; Liang, Y; Ou, F; Sun, X; Tang, M; Wang, W; Zhang, X; Zhao, S; Zu, Y, 2019) |
"Insomnia, depression, and Alzheimer's disease are all neurodegenerative diseases and are associated with the levels of steroid hormones." | 1.51 | The internal link of serum steroid hormones levels in insomnia, depression, and Alzheimer's disease rats: Is there an effective way to distinguish among these three diseases based on potential biomarkers? ( Bi, K; Li, Q; Liu, R; Wang, Z; Xu, H; Yang, X; Zhang, Q, 2019) |
"Quercetin treatment was found to significantly reduce anxiety-like behaviors in mTBI-induced mice." | 1.51 | Quercetin mitigates anxiety-like behavior and normalizes hypothalamus-pituitary-adrenal axis function in a mouse model of mild traumatic brain injury. ( Ghorbanihaghjo, A; Kosari-Nasab, M; Mesgari-Abbasi, M; Salari, AA; Shokouhi, G, 2019) |
"Corticosterone treatment altered all parameters in behavioral tests, leading to a depressive- and anxious-like behavior." | 1.51 | Reversal effect of Riparin IV in depression and anxiety caused by corticosterone chronic administration in mice. ( Barbosa Filho, JM; Capibaribe, VCC; Chaves, RC; da Silva, DMA; de Carvalho, AMR; de Sousa, FCF; Gutierrez, SJC; Lopes, IS; Macêdo, DS; Mallmann, ASV; Oliveira, ICM; Oliveira, NF; Valentim, JT; Vasconcelos, SMM, 2019) |
"However, therapeutic treatments for depression or research on depression is scarce." | 1.51 | A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice. ( Kim, HJ; Lee, DK; Son, H; Yang, JH, 2019) |
" We also examined whether Roman chamomile combined with clomipramine treatment affects hippocampal neurogenesis and serum corticosterone levels." | 1.51 | Roman chamomile inhalation combined with clomipramine treatment improves treatment-resistant depression-like behavior in mice. ( Hashikawa, N; Hashikawa-Hobara, N; Ishikawa, R; Otsuka, A, 2019) |
"Depression is commonly associated with hypothalamic-pituitary adrenal (HPA) axis dysfunction that primarily manifests as aberrant glucocorticoid secretion." | 1.48 | Differential effects of imipramine and CORT118335 (Glucocorticoid receptor modulator/mineralocorticoid receptor antagonist) on brain-endocrine stress responses and depression-like behavior in female rats. ( Balmer, NJ; Caldwell, JL; Estrada, CM; Ghisays, V; Nguyen, ET; Solomon, MB; Streicher, J, 2018) |
"Oxytocin (OXT) has been considered as a neuroregulator mediating social behaviors and stress-related disorders." | 1.48 | Injection of oxytocin into paraventricular nucleus reverses depressive-like behaviors in the postpartum depression rat model. ( Li, H; Li, X; Liu, B; Shi, C; Wang, H; Wang, T; Wang, Y; Wu, Y; Xu, ZD; Yang, Y; Zhang, P, 2018) |
"Baicalin treatment inhibited APPL2/GR signaling pathway and improved neurogenesis at SVZ, OB, and hippocampus in APPL2 Tg mice and chronic corticosterone-induced depression mouse model." | 1.48 | Baicalin Modulates APPL2/Glucocorticoid Receptor Signaling Cascade, Promotes Neurogenesis, and Attenuates Emotional and Olfactory Dysfunctions in Chronic Corticosterone-Induced Depression. ( Deng, R; Du, Q; Gao, C; Li, W; Shen, J; Wang, Q; Xu, A, 2018) |
"Depression is one of the most frequent neuropsychiatric diseases in the western world and its physiological causes are not yet fully understood." | 1.48 | Cholecalciferol counteracts depressive-like behavior and oxidative stress induced by repeated corticosterone treatment in mice. ( Camargo, A; da Silva, EB; Dalmagro, AP; Rikel, L; Simão da Silva, KAB; Zeni, ALB, 2018) |
"Agmatine is a neuromodulator that has been proposed as a therapeutic strategy for the treatment of major depressive disorder (MDD)." | 1.48 | Single administration of agmatine reverses the depressive-like behavior induced by corticosterone in mice: Comparison with ketamine and fluoxetine. ( Bettio, LB; Fraga, DB; Freitas, AE; Gonçalves, FM; Heinrich, IA; Leal, RB; Lopes, MW; Moretti, M; Neis, VB; Olescowicz, G; Rodrigues, ALS; Rosa, PB, 2018) |
"Corticosterone pre-treatment generated oxidative stress, altering antioxidant enzymes in the nervous tissue." | 1.48 | Antioxidant and antidepressant-like effects of Eugenia catharinensis D. Legrand in an animal model of depression induced by corticosterone. ( Alberton, MD; Barauna, SC; Brueckheimer, MB; de Albuquerque, CAC; de Gasper, AL; de Melo, DFM; Delwing-Dal Magro, D; Delwing-De Lima, D; Döhler, AW; Harger, MC; Maia, TP; Micke, GA; Sala, GABN; Siebert, DA, 2018) |
"Thus, mechanical hyperalgesia and allodynia, and the pattern of c-Fos staining in the amygdala subnuclei were evaluated in rats with chronic constriction of the sciatic nerve, as well as sham-operated and naïve rats." | 1.48 | The critical role of amygdala subnuclei in nociceptive and depressive-like behaviors in peripheral neuropathy. ( Antunes, GF; Assis, DV; Gouveia, F; Kuroki, M; Martinez, RCR; Oliveira, CC; Pagano, RL; Santos, LCT; Seno, MDJ, 2018) |
" Our study suggests that the exposure to PAS during an emotional challenge decreases despair-like behavior in rodents that were previously housed in an enriched environment in combination with auditory stimuli." | 1.48 | Exposure to Patterned Auditory Stimuli during Acute Stress Prevents Despair-Like Behavior in Adult Mice That Were Previously Housed in an Enriched Environment in Combination with Auditory Stimuli. ( Cabrera-Muñoz, EA; Flores-Gutiérrez, E; Ortiz-López, L; Ramírez-Rodríguez, GB; Vega-Rivera, NM, 2018) |
"Insulin resistance has been identified as the key mechanism linking depression and diabetes." | 1.46 | Curcumin reverses the depressive-like behavior and insulin resistance induced by chronic mild stress. ( Li, YC; Li, YJ; Qiao, JY; Shen, JD; Wei, Y, 2017) |
"Depression is a recurrent neuropsychiatric disorder that affects millions of individuals worldwide and impact negatively on the patients' social functions and quality of life." | 1.46 | Methyl jasmonate attenuated lipopolysaccharide-induced depressive-like behaviour in mice. ( Adebesin, A; Adeoluwa, OA; Eduviere, AT; Umukoro, S, 2017) |
"Recently, depression has been envisioned as more than an alteration in neurotransmitters centered around receptor signaling pathways." | 1.46 | Fluoxetine coupled with zinc in a chronic mild stress model of depression: Providing a reservoir for optimum zinc signaling and neuronal remodeling. ( Omar, NN; Tash, RF, 2017) |
"Depression is one of the important world-wide health problems." | 1.46 | Can Ocimum basilicum relieve chronic unpredictable mild stress-induced depression in mice? ( Ali, S; Ayuob, NN; El-Mansy, AA; Firgany, AEL, 2017) |
"Comorbid depression was induced by five inescapable foot-shocks (2mA, 2ms duration) at 10s intervals on days 1, 5, 7, and 10." | 1.46 | Metformin and ascorbic acid combination therapy ameliorates type 2 diabetes mellitus and comorbid depression in rats. ( Kumar, M; Nayak, PK; Shivavedi, N; Tej, GNVC, 2017) |
"Depression has become a common public health problem that is showing increasing prevalence." | 1.46 | Evaluation of the antidepressant-like effect of musk in an animal model of depression: how it works. ( Ayuob, NN, 2017) |
"Etazolate (ETZ) is a new generation PDE4 inhibitor with encouraging safety and tolerance profiles." | 1.46 | Molecular modifications by regulating cAMP signaling and oxidant-antioxidant defence mechanisms, produce antidepressant-like effect: A possible mechanism of etazolate aftermaths of impact accelerated traumatic brain injury in rat model. ( Bhatt, S; Jindal, A; Mahesh, R; Pandey, D, 2017) |
" A dose-response study showed that 4 weeks of CORT exposure at 35 μg/ml in the drinking water enhanced the emotionality score of female mice, but with a very small size effect." | 1.46 | Chronic corticosterone administration effects on behavioral emotionality in female c57bl6 mice. ( David, DJ; Gardier, AM; Guilloux, JP; Mekiri, M, 2017) |
"Major depression is a multifactorial disease, involving both environmental and genetic risk factors." | 1.43 | SLC6A15, a novel stress vulnerability candidate, modulates anxiety and depressive-like behavior: involvement of the glutamatergic system. ( Balsevich, G; Chen, A; Dournes, C; Hartmann, J; Holsboer, F; Labermaier, C; Masana, M; Müller, MB; Santarelli, S; Schmidt, MV; Uribe, A; Wagner, KV, 2016) |
"Treatment with berberine prevented these changes above." | 1.43 | Berberine up-regulates the BDNF expression in hippocampus and attenuates corticosterone-induced depressive-like behavior in mice. ( Fang, XY; Hu, CY; Jin, SL; Li, YC; Ma, LG; Pei, YY; Shen, JD, 2016) |
"Depression is associated with hypothalamic-pituitary-adrenal (HPA) axis hyperactivity and testosterone exerts suppressive effects on the HPA axis." | 1.43 | Testosterone has antidepressant-like efficacy and facilitates imipramine-induced neuroplasticity in male rats exposed to chronic unpredictable stress. ( Chow, C; Galea, LA; Hamson, DK; Lieblich, SE; Tehrani, A; Wainwright, SR; Workman, JL, 2016) |
"Depression is a common psychopathological disorders." | 1.43 | Zinc and imipramine reverse the depression-like behavior in mice induced by chronic restraint stress. ( Ding, Q; Huang, J; Li, H; Mo, F; Shen, H; Shen, Z; Tian, X; Wang, X, 2016) |
"Depression was evaluated in all experimental groups using tail suspension and forced swim test on days 1, 5, 10 and 15, 2h after pentylenetetrazole challenge." | 1.43 | Adjuvant indoleamine 2,3-dioxygenase enzyme inhibition for comprehensive management of epilepsy and comorbid depression. ( Goel, RK; Singh, T, 2016) |
" Furthermore, acute treatment of NPFFR2 agonists in wild-type (WT) mice enhanced the activity of the HPA axis, and chronic administration resulted in depressive and anxiety-like behaviors." | 1.43 | Chronic activation of NPFFR2 stimulates the stress-related depressive behaviors through HPA axis modulation. ( Chang, CC; Chen, JC; Chen, TC; Day, YJ; Huang, GJ; Lin, YT; Liu, TY; Yang, CY; Yu, YL, 2016) |
"Depression is a heterogeneous disorder characterized by alterations at psychological, behavioural, physiological, neurophysiological, and neurochemical levels." | 1.43 | Simultaneous Changes in Sleep, qEEG, Physiology, Behaviour and Neurochemistry in Rats Exposed to Repeated Social Defeat Stress. ( Ahnaou, A; Drinkenburg, WH, 2016) |
"Pneumococcal meningitis is a life-threatening infection of the central nervous system (CNS) with a high mortality rate." | 1.43 | Depression-Like Adult Behaviors may be a Long-Term Result of Experimental Pneumococcal Meningitis in Wistar Rats Infants. ( Barichello, T; Dominguini, D; Generoso, JS; Jornada, LK; Quevedo, J; Sharin, VS; Simões, LR; Souza, LB; Teixeira, AL; Valvassori, SS, 2016) |
"Musk has an antidepressant-like effect in an animal model of depression, so it is advisable to assess its efficacy in people continually exposed to stressors." | 1.43 | The antidepressant effect of musk in an animal model of depression: a histopathological study. ( Ahmed, SM; Ali, SS; Ayuob, NN; El Wahab, MGA; Suliaman, M, 2016) |
"We demonstrate that depression is associated with decreased gut microbiota richness and diversity." | 1.43 | Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat. ( Beers, S; Borre, Y; Clarke, G; Cryan, JF; Deane, J; Dinan, TG; El Aidy, S; Fitzgerald, P; Hoban, AE; Kelly, JR; Kennedy, PJ; Moloney, G; O' Brien, C; Patterson, E; Ross, P; Scott, K; Scott, L; Stanton, C, 2016) |
"Major depression is a life threatening neuropsychiatric disorder that produces mental illness and major cause of morbidity." | 1.43 | Neuroprotective, Neurotrophic and Anti-oxidative Role of Bacopa monnieri on CUS Induced Model of Depression in Rat. ( Kumar, S; Mondal, AC, 2016) |
" Chronic administration of BB effectively reversed these alterations." | 1.43 | Bilobalide alleviates depression-like behavior and cognitive deficit induced by chronic unpredictable mild stress in mice. ( Shui, L; Song, Z; Tai, F; Wang, S; Wu, R, 2016) |
" Rearing in social isolation increased stress reactivity in comparison to both controls and in combination with periodic maternal separation, without affecting the coping strategy associated with the forced swimming test." | 1.43 | Early Life Stress Increases Metabolic Risk, HPA Axis Reactivity, and Depressive-Like Behavior When Combined with Postweaning Social Isolation in Rats. ( Gomez, C; Junco, M; Lajud, N; Vargas, J, 2016) |
"Indeed, here we found that cardiac hypertrophy and heart failure induced by TAC were associated with depression-like behaviors concomitant with downregulation of σ1R expression in brain 6 weeks after surgery." | 1.43 | Corticosteroids Mediate Heart Failure-Induced Depression through Reduced σ1-Receptor Expression. ( Bhuiyan, MS; Fukunaga, K; Han, F; Hasegawa, H; Kanai, H; Shinoda, Y; Tagashira, H; Zhang, C, 2016) |
"Depression is the most common form of mental disability in the world." | 1.43 | Anhedonia but not passive floating is an indicator of depressive-like behavior in two chronic stress paradigms. ( Freiman, SV; Gulyaeva, NV; Lazareva, NA; Levchenko, OA; Levshina, IP; Novikova, MR; Onufriev, MV; Stepanichev, MY; Tishkina, AO, 2016) |
"Corticosterone levels were significantly increased compared to control values (p<0." | 1.43 | Chronic unpredictable mild stress paradigm in male Wistar rats: effect on anxiety- and depressive-like behavior. ( Belovičová, K; Bögi, E; Koprdova, R; Mach, M; Okuliarová, M; Sedláčková, N; Ujházy, E, 2016) |
"Depression is a common psychiatric disorder associated with chronic stress." | 1.42 | Insulin-like growth factor 2 mitigates depressive behavior in a rat model of chronic stress. ( Cao, WY; Dai, RP; Duan, J; Hu, ZL; Li, CQ; Li, F; Luo, YW; Wang, XQ; Xu, Y; Zhang, JY; Zhong, XL; Zhou, M, 2015) |
" Repeated CORT dosing caused depression-like behavior in mice as indicated by increased despair effects in forced swim test (FST) and anhedonia in sucrose preference test." | 1.42 | Effect of a novel 5-HT3 receptor antagonist 4i, in corticosterone-induced depression-like behavior and oxidative stress in mice. ( Gupta, D; Kurhe, Y; Radhakrishnan, M, 2015) |
"The range of defects that fall within fetal alcohol spectrum disorder (FASD) includes persistent behavioral problems, with anxiety and depression being two of the more commonly reported issues." | 1.42 | Hypothalamic-pituitary-adrenal axis and behavioral dysfunction following early binge-like prenatal alcohol exposure in mice. ( Fish, EW; O'Leary-Moore, SK; Parnell, SE; Sulik, KK; Wieczorek, L, 2015) |
"Post-traumatic stress disorder (PTSD) is a stress-related mental disorder caused by traumatic experiences." | 1.42 | Long-term effects of early adolescent stress: dysregulation of hypothalamic-pituitary-adrenal axis and central corticotropin releasing factor receptor 1 expression in adult male rats. ( Jiang, H; Li, C; Liu, D; Liu, Y; Lu, C; Pan, F; Yin, S, 2015) |
"Chronic pain and depression are two complex states that often coexist in the clinical setting and traditional antidepressants and analgesics have shown limited clinical efficacy." | 1.42 | m-Trifluoromethyl-diphenyl diselenide, a multi-target selenium compound, prevented mechanical allodynia and depressive-like behavior in a mouse comorbid pain and depression model. ( Brüning, CA; Duarte, MM; Gai, BM; Martini, F; Nogueira, CW; Sampaio, TB; Soares, SM, 2015) |
" Chronic administration of lithium chloride or valproic acid, two clinically effective mood stabilizers, reverses the majority of these behavioral abnormalities." | 1.42 | Mice heterozygous for cathepsin D deficiency exhibit mania-related behavior and stress-induced depression. ( Duan, S; Han, Y; Li, X; Lou, H; Lu, Y; Zhen, X; Zhou, R; Zhu, L, 2015) |
"Corticosterone levels were increased in the untreated STZ group; SMV and clomipramine significantly decreased corticosterone levels in the STZ groups, but had no effect on the CTR groups." | 1.42 | Antidepressant-like effect of simvastatin in diabetic rats. ( ElBatsh, MM, 2015) |
"Rats treated with sanggenon G also exhibited a decrease in the limbic hypothalamic-pituitary-adrenal (HPA) axis response to the FST, as indicated by attenuation of the corticosterone response and decreased c-Fos immunoreactivity in the hypothalamic paraventricular nucleus (PVN)." | 1.42 | Antidepressant-Like Effects of Sanggenon G, Isolated from the Root Bark of Morus alba, in Rats: Involvement of the Serotonergic System. ( Baek, NI; Han, D; Jung, JW; Kim, IH; Kim, YT; Lim, DW; Park, JH, 2015) |
"Plumbagin has been reported to be neuroprotective, so it might possess antidepressant activity." | 1.42 | Antidepressant-like activity of plumbagin in unstressed and stressed mice. ( Bansal, S; Dhingra, D, 2015) |
"Myricetin treatment improved activities of glutathione peroxidase (GSH-PX) in the hippocampus of stressed mice." | 1.42 | Myricetin Attenuates Depressant-Like Behavior in Mice Subjected to Repeated Restraint Stress. ( Cui, L; Ma, Z; Wang, G; Wang, Q, 2015) |
"Anxiety and depression are common in diabetics." | 1.40 | Anxiety- and depression-like behavior are correlated with leptin and leptin receptor expression in prefrontal cortex of streptozotocin-induced diabetic rats. ( Agilkaya, S; Aksu, I; Ates, M; Baykara, B; Buyuk, E; Cetinkaya, C; Cingoz, S; Dayi, A; Kiray, M; Sisman, AR; Uysal, N, 2014) |
"These findings highlight how genetic predisposition shapes individuals' response to early life stress." | 1.40 | High novelty-seeking rats are resilient to negative physiological effects of the early life stress. ( Akil, H; Clinton, SM; Watson, SJ, 2014) |
"Corticosterone was quantified in 11-week-old mice." | 1.40 | Maternal separation modifies behavioural and neuroendocrine responses to stress in CCR7 deficient mice. ( Baune, BT; Corrigan, F; Harrison, EL; Jaehne, EJ; Jawahar, MC, 2014) |
"Depression is generally a recurrent psychiatric disorder." | 1.40 | A neuroendocrine mechanism of co-morbidity of depression-like behavior and myocardial injury in rats. ( Baoying, J; Lei, W; Lingjia, Q; Rui, Z; Wei, L; Xinxing, W, 2014) |
"Depression is a serious mental disorder in the world, but the underlying mechanisms remain unclear and the effective cures are scarce." | 1.40 | Iptakalim confers an antidepressant effect in a chronic mild stress model of depression through regulating neuro-inflammation and neurogenesis. ( Ding, JH; Geng, F; Hu, G; Lu, M; Yang, JZ, 2014) |
" Clinical investigations revealed that long-term use of statins appeared to be associated with a lower risk of anxiety and depression." | 1.40 | Simvastatin treatment exerts antidepressant-like effect in rats exposed to chronic mild stress. ( Chang, AY; Lin, PY; Lin, TK, 2014) |
"Treatment with emodin normalized the change of plasma corticosterone level, which demonstrated that emodin could partially restore CUMS-induced HPA axis impairments." | 1.40 | Emodin opposes chronic unpredictable mild stress induced depressive-like behavior in mice by upregulating the levels of hippocampal glucocorticoid receptor and brain-derived neurotrophic factor. ( Fu, Q; Li, M; Li, S; Li, Y; Ma, S; Xue, J, 2014) |
"Patients suffering from neuropathic pain have a higher incidence of mood disorders such as depression." | 1.40 | Neuropathic pain-induced depressive-like behavior and hippocampal neurogenesis and plasticity are dependent on TNFR1 signaling. ( Bernardes, D; Bethea, JR; Brambilla, R; Dellarole, A; Grilli, M; Morton, P; Summers, S; Walters, W, 2014) |
"The corticosterone-treated rats showed significantly reduced sleep time, disinhibition of rapid-eye-movement (REM) sleep and altered power spectra during non-REM sleep." | 1.40 | Correlations between depression behaviors and sleep parameters after repeated corticosterone injections in rats. ( Cao, Q; Cui, SY; Cui, XY; Huang, YL; Li, SJ; Sheng, ZF; Wang, ZJ; Yu, B; Zhang, XQ; Zhang, YH, 2014) |
" Additionally, the effects of chronic administration of the tricyclic antidepressant imipramine and the anti-TNF-α pentoxyphylline were investigated." | 1.40 | Lipopolysaccharide repeated challenge followed by chronic mild stress protocol introduces a combined model of depression in rats: reversibility by imipramine and pentoxifylline. ( Abd-Alkhalek, HA; Abdel-tawab, AM; Aboul-Fotouh, S; El Tabbal, M; Elgarf, AS; Farrag, KA; Hammouda, GA; Hassan, AN; Kassim, SK, 2014) |
"Corticosterone treatment induced longer immobility times in the FST, reflecting depressive-like behaviour." | 1.40 | Long-term corticosterone exposure decreases insulin sensitivity and induces depressive-like behaviour in the C57BL/6NCrl mouse. ( Blokland, A; Cañete, R; Pawluski, JL; Sierksma, AS; Steinbusch, HW; Vaessen, KR; van Donkelaar, EL, 2014) |
"Corticosterone treatment caused a depressive-like behavior, evidenced by increased immobility time in the tail suspension test and decreased time in which mice spent grooming in the splash test." | 1.40 | Folic acid prevents depressive-like behavior induced by chronic corticosterone treatment in mice. ( Bettio, LE; Colla, A; Lieberknecht, V; Moretti, M; Ribeiro, CM; Rodrigues, AL; Rosa, PB, 2014) |
"Honokiol (HNK) is a biphenolic neolignan possessing multiple biological activities including antioxidant, anti-inflammatory, anxiolytic, antidepressant and neuroprotective." | 1.40 | Honokiol abrogates lipopolysaccharide-induced depressive like behavior by impeding neuroinflammation and oxido-nitrosative stress in mice. ( Baruah, CC; Dwivedi, S; Hazarika, NK; Jangra, A; Kumar, P; Lahkar, M; Sulakhiya, K, 2014) |
"Depression has been considered to be both a symptom and risk factor of AD." | 1.39 | Effects of corticosterone and amyloid-beta on proteins essential for synaptic function: implications for depression and Alzheimer's disease. ( Chang, RC; Cheng, SS; Ho, YS; Hung, CH; Law, AC; Wong, GT; Wuwongse, S; Zhang, NQ, 2013) |
"Agmatine treatment also normalized the elevated corticosterone levels and prevented the body weight changes in chronically stressed animals." | 1.39 | Agmatine attenuates chronic unpredictable mild stress induced behavioral alteration in mice. ( Aglawe, MM; Dixit, MP; Faldu, DS; Kotagale, NR; Sakaria, JN; Taksande, BG; Umekar, MJ, 2013) |
"Treatment with baicalin (10, 20, 40 mg/kg) prevented these abnormalities induced by CMS." | 1.39 | Chronic treatment with baicalin prevents the chronic mild stress-induced depressive-like behavior: involving the inhibition of cyclooxygenase-2 in rat brain. ( Jiao, S; Li, J; Li, YC; Shen, JD; Wang, R; Yi, LT, 2013) |
"Coenzyme Q10 (CoQ10) is an essential cofactor in the mitochondrial electron transport pathway and has a powerful antioxidant capacity." | 1.39 | Coenzyme Q10 displays antidepressant-like activity with reduction of hippocampal oxidative/nitrosative DNA damage in chronically stressed rats. ( Aboul-Fotouh, S, 2013) |
"Anxiety and depression are considered as stress-related disorders, which present considerable sex differentiation." | 1.38 | Behavioral sexual dimorphism in models of anxiety and depression due to changes in HPA axis activity. ( Antoniou, K; Dalla, C; Dendi, A; Kokras, N; Mikail, HG; Papadopoulou-Daifoti, Z; Sideris, AC, 2012) |
"Melancholic depression has typically been associated with HPA hyperactivity, while atypical depression has been linked with HPA hypoactivity." | 1.38 | Lack of elevations in glucocorticoids correlates with dysphoria-like behavior after repeated social defeat. ( Bhatnagar, S; Bowens, N; Heydendael, W; Jacobson, L, 2012) |
"Piperine (1 μM) co-treatment also significantly decreased intracellular reactive oxygen species level, and enhanced superoxide dismutase activity and total glutathione level in corticosterone-treated PC12 cells." | 1.38 | Protective effects of piperine against corticosterone-induced neurotoxicity in PC12 cells. ( Che, CT; Huang, Z; Ip, SP; Mao, QQ; Xian, YF, 2012) |
"Corticosterone induced an increase glutamate and a decrease in GABA release in hippocampal slices, which was reversed by venlafaxine." | 1.38 | Long lasting effects of early-life stress on glutamatergic/GABAergic circuitry in the rat hippocampus. ( Horrillo, I; Martisova, E; Meana, JJ; Ortega, JE; Ramírez, MJ; Solas, M; Tordera, RM, 2012) |
"Depression is a debilitating mental illness and is often comorbid with metabolic disorders such as type 2 diabetes." | 1.38 | Adiponectin is critical in determining susceptibility to depressive behaviors and has antidepressant-like activity. ( Cheng, SY; Ding, J; Guo, M; Liu, F; Liu, J; Liu, M; Lu, XY; Scherer, PE; Zhang, D, 2012) |
"Chronic pain and depression are two complex states with sensory/somatic and emotional components, and they may mutually exacerbate one another in conditions of comorbidity, leading to a poorer prognosis." | 1.38 | Depressive-like states heighten the aversion to painful stimuli in a rat model of comorbid chronic pain and depression. ( Berrocoso, E; Bravo, L; Leza, JC; Mico, JA; Pérez-Nievas, B; Rey-Brea, R, 2012) |
"Depression is a life-threatening psychiatric disorder characterized with a long-term hypercortisolemia in depressed patients." | 1.38 | Synaptic plasticity, but not hippocampal neurogenesis, mediated the counteractive effect of wolfberry on depression in rats(1). ( Chang, RC; Lau, BW; Lee, TM; Ma, H; So, KF; Yau, SY; Zhang, E, 2012) |
"Depression is a major psychiatric disorder affecting nearly 21% of the world population and imposes a substantial health burden on society." | 1.37 | Protective effects of flavonoid extract from Apocynum venetum leaves against corticosterone-induced neurotoxicity in PC12 cells. ( Liu, C; Ma, F; Pan, F; Shi, D; Zhang, Y; Zheng, M, 2011) |
"Icariin is a major constituent of flavonoids isolated from the herb Epimedium." | 1.37 | Icariin attenuates social defeat-induced down-regulation of glucocorticoid receptor in mice. ( Dong, J; Du, J; Le, J; Liu, B; Wu, J; Xu, C; Xu, Y, 2011) |
"Major depression is an independent risk factor for the development of cardiovascular disease." | 1.37 | Altered aortic vascular reactivity in the unpredictable chronic mild stress model of depression in mice: UCMS causes relaxation impairment to ACh. ( Belzung, C; Camus, V; d'Audiffret, A; Freslon, JL; Frisbee, J; Isingrini, E; O'Donnell, J; Surget, A, 2011) |
"Depression is a stress related disease, as hormones of the stress-axis can modify mood." | 1.37 | Do stress hormones connect environmental effects with behavior in the forced swim test? ( Domokos, Á; Mergl, Z; Mikics, É; Pintér, O; Zelena, D, 2011) |
"Luteolin is a flavonoid contained in many plants and with a variety of known pharmacological properties such as anti-inflammatory, anti-anxiety, and memory-improving effects, suggesting that luteolin penetrates into the brain." | 1.37 | Luteolin shows an antidepressant-like effect via suppressing endoplasmic reticulum stress. ( Hara, H; Ishisaka, M; Kakefuda, K; Shimazawa, M; Tsuruma, K; Tsuruta, A; Yamauchi, M, 2011) |
" This study was aimed to assess the anxiolytic and antidepressant-like properties of tiagabine, an inhibitor of the GABA transporter-1 (GAT-1), after acute and chronic administration in C57BL/6JOlaHsD mice with paroxetine as a positive control." | 1.36 | Long-term anxiolytic and antidepressant-like behavioural effects of tiagabine, a selective GABA transporter-1 (GAT-1) inhibitor, coincide with a decrease in HPA system activity in C57BL/6 mice. ( Erhardt, A; Holsboer, F; Keck, ME; Mueller, MB; Ohl, F; Sillaber, I; Thoeringer, CK, 2010) |
"The treatment with imipramine reversed all the parameters described above." | 1.36 | Depressive-like parameters in sepsis survivor rats. ( Barichello, T; Cassol, OJ; Comim, CM; Constantino, LC; Constantino, LS; Dal-Pizzol, F; Kapczinski, F; Petronilho, F; Quevedo, J; Stertz, L, 2010) |
"Treatment with mifepristone decreased immobility and increased swimming (but not climbing) behavior in the FST, consistent with anti-depressant action." | 1.36 | Mifepristone decreases depression-like behavior and modulates neuroendocrine and central hypothalamic-pituitary-adrenocortical axis responsiveness to stress. ( Herman, JP; Solomon, MB; Wulsin, AC, 2010) |
"Sepsis is characterized by a systemic inflammatory response of the immune system against an infection, presenting with hypothalamic-pituitary-adrenal (HPA) axis dysfunction, behavior alterations, and high mortality." | 1.36 | Low dose dexamethasone reverses depressive-like parameters and memory impairment in rats submitted to sepsis. ( Cassol, OJ; Comim, CM; Constantino, LS; Dal-Pizzol, F; Petronilho, F; Quevedo, J; Streck, EL, 2010) |
"In the long run, insufficient sleep may have repercussions for health and may sensitize individuals to psychiatric diseases." | 1.35 | Chronically restricted sleep leads to depression-like changes in neurotransmitter receptor sensitivity and neuroendocrine stress reactivity in rats. ( Cetin, T; den Boer, JA; Hagewoud, R; Luiten, PG; Meerlo, P; Novati, A; Roman, V, 2008) |
"Melatonin is a hormone primarily synthesized by the pineal gland and has been shown to govern seasonal and circadian rhythms, as well as the immune system, certain behaviours, and responses to stress." | 1.35 | Antidepressant-like effects of melatonin in the mouse chronic mild stress model. ( Caumo, W; Detanico, BC; Elisabetsky, E; Freitas, JJ; Hidalgo, MP; Lhullier, FL; Piato, AL, 2009) |
"Depression is frequently reported in epilepsy patients; however, mechanisms of co-morbidity between epilepsy and depression are poorly understood." | 1.35 | Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy. ( Bragin, A; Kwon, YS; Mazarati, AM; Pineda, E; Sankar, R; Shin, D; Taylor, AN; Tio, D, 2009) |
"Treatment with desipramine (20mg/kg, i." | 1.35 | Increased water temperature renders single-housed C57BL/6J mice susceptible to antidepressant treatment in the forced swim test. ( Bächli, H; Habersetzer, U; Steiner, MA; Wotjak, CT, 2008) |
" The latter effect could be mimicked in C57BL/6N mice by acute, subchronic, and chronic administration of the selective CB1 antagonist SR141716." | 1.35 | Antidepressant-like behavioral effects of impaired cannabinoid receptor type 1 signaling coincide with exaggerated corticosterone secretion in mice. ( Holsboer, F; Lutz, B; Marsicano, G; Nestler, EJ; Steiner, MA; Wotjak, CT, 2008) |
"We have reported that neonatal bacterial infection in rats leads to exaggerated brain cytokine production, as well as memory impairments, to a subsequent peripheral immune challenge in adulthood, and therefore predicted that stressor-induced depressive-like symptoms would be more severe in these rats as well." | 1.35 | Bacterial infection early in life protects against stressor-induced depressive-like symptoms in adult rats. ( Amat, J; Bilbo, SD; Maier, SF; Paul, ED; Watkins, LR; Yirmiya, R, 2008) |
" Daily administration of onion powder at a dosage of 50 mg/kg of body weight/day for 14 days significantly reduced the immobility time in FST without changing the motor dysfunction, indicating that the daily consumption of onion exerted antidepressant-like activity." | 1.35 | Antidepressant-like effect of onion (Allium cepa L.) powder in a rat behavioral model of depression. ( Kawai, Y; Sakakibara, H; Terao, J; Yoshino, S, 2008) |
"Treatment with piperine (6." | 1.34 | Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanisms. ( Li, S; Li, W; Matsumoto, K; Tang, Y; Wang, C; Wang, M, 2007) |
"Imipramine treatment offset all the behavioral and neurochemical stress-induced modifications." | 1.34 | Hypothalamus-pituitary-adrenal modifications consequent to chronic stress exposure in an experimental model of depression in rats. ( Cassanelli, A; Danielli, B; De Montis, MG; Raone, A; Rauggi, R; Scheggi, S, 2007) |
"Phenelzine did not increase paraventricular hypothalamus CRH or vasopressin mRNA in ADX mice lacking corticosterone replacement." | 1.33 | Chronic treatment with the monoamine oxidase inhibitor phenelzine increases hypothalamic-pituitary-adrenocortical activity in male C57BL/6 mice: relevance to atypical depression. ( Han, J; Jacobson, L; Kier, A, 2005) |
" E(2), 10 mug, compared to vehicle or 50 mug, reduced anxiety and depressive behavior of sham and adrenalectomized rats administered the low dosage of corticosterone, but not vehicle or the high dosage of corticosterone, suggesting that there may be an optimal level of corticosterone necessary for E(2) to exert these effects." | 1.33 | Antianxiety and antidepressive behavior produced by physiological estradiol regimen may be modulated by hypothalamic-pituitary-adrenal axis activity. ( Frye, CA; Walf, AA, 2005) |
"Electroconvulsive seizure (ECS)-treatment, an animal model for the antidepressant treatment electroconvulsive therapy, can enhance proliferation of glial cells." | 1.33 | Corticosterone-induced inhibition of gliogenesis in rat hippocampus is counteracted by electroconvulsive seizures. ( Ekstrand, J; Hellsten, J; Lindgren, H; Tingström, A; Wennström, M, 2006) |
"Since depression is a multifaceted disorder, and a number of symptoms may be present, including circadian rhythm disturbances, we attempted to find the chronobiological abnormalities in CMS rats." | 1.33 | Chronobiological disturbances with hyperthermia and hypercortisolism induced by chronic mild stress in rats. ( Higuchi, S; Morikawa, T; Ohdo, S; To, H; Ushijima, K, 2006) |
"Anxiety and depression are currently classified as separate clinical syndromes despite considerable similarities in their symptoms, pathophysiological substrates and response to treatment interventions." | 1.33 | Modeling the anxiety-depression continuum hypothesis in domestic fowl chicks. ( Acevedo, EO; Cartwright, CM; Feltenstein, MW; Sufka, KJ; Warnick, JE; Webb, HE, 2006) |
"Corticosterone treatment was found to induce a significant attenuation in the response to 8-OHDPAT, indicating functional desensitization of somatodendritic 5-HT(1A) autoreceptors." | 1.32 | Flattening the corticosterone rhythm attenuates 5-HT1A autoreceptor function in the rat: relevance for depression. ( Gartside, SE; Ingram, CD; Leitch, MM; McQuade, R; Young, AH, 2003) |
"Corticosterone treatment decreased [3H] 8-hydroxy-2-(di-n-propylamino)tetralin binding to the 5-hydroxytryptamine1A receptor in the cortex but not in the hippocampus." | 1.32 | Implantation of a slow release corticosterone pellet induces long-term alterations in serotonergic neurochemistry in the rat brain. ( Bush, VL; Fone, KC; Marsden, CA; Middlemiss, DN, 2003) |
"Depression is a multifactorial illness and genetic factors play a role in its etiology." | 1.32 | Behavioral, neurochemical, and electrophysiological characterization of a genetic mouse model of depression. ( Adrien, J; Bouali, S; Costentin, J; El Yacoubi, M; Hamon, M; Leroux-Nicollet, I; Naudon, L; Popa, D; Vaugeois, JM, 2003) |
"Fluoxetine treatment also reversed the deficit in escape latency observed in animals exposed to IS." | 1.32 | Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment. ( Duman, RS; Malberg, JE, 2003) |
"Melatonin has been demonstrated to increase activity in the forced swim test (FST), a putative model of antidepressant efficacy, indicating that it may possess antidepressant-like qualities." | 1.32 | Corticosterone attenuates the antidepressant-like effects elicited by melatonin in the forced swim test in both male and female rats. ( Brotto, LA; Gorzalka, BB; Hill, MN; Lee, TT, 2003) |
"Corticosterone serum levels were elevated in both sexes." | 1.32 | Sex differences in behavioral, neurochemical and neuroendocrine effects induced by the forced swim test in rats. ( Antoniou, K; Dalla, C; Drossopoulou, G; Kitraki, E; Papadopoulou-Daifoti, Z; Papalexi, E; Papathanasiou, G, 2004) |
"The body weight gain was reduced in males only." | 1.31 | Corticotropin-releasing hormone mRNA levels in response to chronic mild stress rise in male but not in female rats while tyrosine hydroxylase mRNA levels decrease in both sexes. ( Duncko, R; Jezová, D; Kiss, A; Rusnák, M; Skultétyová, I, 2001) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 20 (2.32) | 18.7374 |
1990's | 16 (1.85) | 18.2507 |
2000's | 114 (13.21) | 29.6817 |
2010's | 537 (62.22) | 24.3611 |
2020's | 176 (20.39) | 2.80 |
Authors | Studies |
---|---|
Liu, W | 6 |
Wang, H | 9 |
Li, X | 10 |
Xu, Y | 8 |
Zhang, J | 6 |
Wang, W | 10 |
Gong, Q | 2 |
Qiu, X | 1 |
Zhu, J | 2 |
Mao, F | 1 |
Zhang, H | 7 |
Li, J | 16 |
Salgin-Goksen, U | 1 |
Telli, G | 1 |
Erikci, A | 1 |
Dedecengiz, E | 1 |
Tel, BC | 1 |
Kaynak, FB | 1 |
Yelekci, K | 1 |
Ucar, G | 1 |
Gokhan-Kelekci, N | 1 |
Yu, Z | 2 |
Li, D | 3 |
Zhai, S | 1 |
Xu, H | 3 |
Liu, H | 4 |
Ao, M | 1 |
Zhao, C | 1 |
Jin, W | 2 |
Yu, L | 1 |
Bai, G | 1 |
Qiao, Y | 1 |
Lo, PC | 1 |
Song, L | 5 |
Yang, Y | 9 |
Duan, L | 1 |
Wei, S | 2 |
Li, M | 6 |
Huang, S | 1 |
Zhang, B | 3 |
Wang, Q | 9 |
Yang, C | 1 |
Hong, C | 1 |
Chen, L | 5 |
Kong, W | 1 |
Zhang, D | 2 |
Wang, L | 3 |
Zhao, J | 4 |
Zhong, X | 1 |
Zhang, G | 1 |
Huang, Z | 5 |
Qiu, F | 1 |
Tang, Y | 2 |
Yang, J | 4 |
Ye, C | 1 |
Xu, X | 1 |
Cai, M | 2 |
Zhang, Y | 15 |
Lu, H | 1 |
Mo, F | 2 |
Li, H | 7 |
Shen, H | 3 |
Sakurai, K | 1 |
Itou, T | 1 |
Morita, M | 1 |
Kasahara, E | 1 |
Moriyama, T | 1 |
Macpherson, T | 1 |
Ozawa, T | 1 |
Miyamoto, Y | 1 |
Yoneda, Y | 1 |
Sekiyama, A | 1 |
Oka, M | 1 |
Hikida, T | 1 |
Gouveia, FV | 1 |
Germann, J | 1 |
Oliveira, CC | 2 |
Castro, MC | 1 |
Antunes, GF | 2 |
Gomes, GCV | 1 |
Pinto, TRC | 1 |
Martinez, RCR | 2 |
Valle, AC | 1 |
Oliveira, TQ | 1 |
Chaves Filho, AJM | 2 |
Jucá, PM | 2 |
Soares, MVR | 2 |
Cunha, NL | 1 |
Vieira, CFX | 1 |
Gadelha Filho, CVJ | 1 |
Viana, GA | 1 |
De Oliveira, GMF | 1 |
Macedo, DS | 6 |
Vasconcelos, SMM | 5 |
Flores-Burgess, A | 1 |
Millón, C | 1 |
Gago, B | 1 |
García-Durán, L | 1 |
Cantero-García, N | 1 |
Puigcerver, A | 1 |
Narváez, JA | 1 |
Fuxe, K | 1 |
Santín, L | 1 |
Díaz-Cabiale, Z | 1 |
Ngoupaye, GT | 3 |
Mokgokong, M | 1 |
Madlala, T | 1 |
Mabandla, MV | 1 |
Gao, ZY | 1 |
Chen, TY | 1 |
Yu, TT | 1 |
Zhang, LP | 1 |
Zhao, SJ | 1 |
Gu, XY | 1 |
Pan, Y | 2 |
Kong, LD | 1 |
Luo, Y | 1 |
Hou, X | 2 |
Lu, K | 1 |
He, Y | 1 |
Yang, B | 4 |
Qin, Y | 2 |
Veenit, V | 2 |
Zhang, X | 5 |
Ambrosini, A | 1 |
Sousa, V | 1 |
Svenningsson, P | 2 |
Chen, X | 3 |
Yang, T | 1 |
Zhang, C | 12 |
Ma, Z | 2 |
Aleksic, M | 1 |
Brkic, Z | 5 |
Petrovic, Z | 3 |
Francija, E | 2 |
Lukic, I | 2 |
Adzic, M | 5 |
Eskandari, F | 1 |
Salimi, M | 1 |
Hedayati, M | 1 |
Zardooz, H | 1 |
Xu, S | 1 |
Zhao, X | 2 |
Zhu, Z | 1 |
He, M | 2 |
Zheng, X | 1 |
Zhu, L | 3 |
Lu, S | 1 |
Bai, M | 1 |
Li, Y | 10 |
Xu, E | 1 |
Dos Santos, BM | 2 |
Pereira, GC | 3 |
Piton, E | 2 |
Fialho, MFP | 2 |
Becker, G | 1 |
da Silva Carlotto, M | 1 |
Camargo, LFM | 1 |
Ramanzini, LG | 1 |
Oliveira, SM | 1 |
Trevisan, G | 2 |
Zanchet, EM | 1 |
Pillat, MM | 1 |
Bochi, GV | 3 |
Ryan-Coats, SK | 1 |
Hughes, SD | 1 |
Holz, FM | 1 |
Kreger, RB | 1 |
Koulibali, CI | 1 |
Khan, HA | 1 |
Harris, KC | 1 |
Kelly, AE | 1 |
Epps, SA | 1 |
Naghibi, S | 1 |
Barzegari, A | 1 |
Shariatzadeh, M | 1 |
Vatandoust, M | 1 |
Ahmadi, M | 1 |
Mahdinia, E | 1 |
Neghabi, F | 1 |
Rajabpour, A | 1 |
Sadat Aleahmad, A | 1 |
Sadat Balaghati, F | 1 |
Sadat Naserimanesh, S | 1 |
Saeedipour, M | 1 |
Sadeghi, O | 1 |
Yeganeh, F | 1 |
Salari, AA | 14 |
Wang, Z | 10 |
Cheng, Y | 2 |
Lu, Y | 5 |
Sun, G | 2 |
Pei, L | 2 |
Allen, J | 4 |
Romay-Tallon, R | 5 |
Mitchell, MA | 2 |
Brymer, KJ | 3 |
Johnston, J | 2 |
Sánchez-Lafuente, CL | 2 |
Pinna, G | 2 |
Kalynchuk, LE | 12 |
Caruncho, HJ | 8 |
Moraga-Amaro, R | 1 |
Guerrin, CGJ | 1 |
Reali Nazario, L | 1 |
Lima Giacobbo, B | 1 |
J O Dierckx, RA | 1 |
Stehberg, J | 1 |
de Vries, EFJ | 1 |
Doorduin, J | 1 |
Zhao, H | 3 |
Jiang, M | 2 |
Miao, M | 1 |
Hu, YQ | 1 |
Niu, TT | 1 |
Xu, JM | 1 |
Peng, L | 2 |
Sun, QH | 1 |
Huang, Y | 3 |
Zhou, J | 6 |
Ding, YQ | 1 |
Ponce-Regalado, MD | 1 |
Salazar-Juárez, A | 1 |
Rojas-Espinosa, O | 1 |
Contis-Montes de Oca, A | 1 |
Hurtado-Alvarado, G | 1 |
Arce-Paredes, P | 1 |
Pérez-Sánchez, G | 1 |
Pavón, L | 1 |
Girón-Pérez, MI | 1 |
Hernández-Pando, R | 1 |
Alvarez-Sánchez, ME | 1 |
Becerril-Villanueva, E | 1 |
Rupasinghe, R | 1 |
Dezsi, G | 1 |
Ozturk, E | 1 |
Carron, S | 1 |
Hudson, MR | 1 |
Casillas-Espinosa, PM | 1 |
Jones, NC | 1 |
Farajdokht, F | 2 |
Oghbaei, F | 1 |
Sadigh-Eteghad, S | 2 |
Majdi, A | 1 |
Aghsan, SR | 1 |
Farhoudi, M | 1 |
Vahidi-Eyrisofla, N | 1 |
Mahmoudi, J | 2 |
Ramadan, B | 1 |
Cabeza, L | 1 |
Cramoisy, S | 1 |
Houdayer, C | 1 |
Andrieu, P | 1 |
Millot, JL | 1 |
Haffen, E | 1 |
Risold, PY | 1 |
Peterschmitt, Y | 1 |
Lim, DW | 5 |
Han, D | 4 |
Lee, C | 4 |
Yamauchi, T | 2 |
Yoshioka, T | 1 |
Yamada, D | 1 |
Hamano, T | 1 |
Ikeda, M | 1 |
Kamei, M | 1 |
Otsuki, T | 1 |
Sato, Y | 1 |
Nii, K | 1 |
Suzuki, M | 1 |
Iriyama, S | 1 |
Yoshizawa, K | 2 |
Nishino, S | 1 |
Ichikawa, H | 1 |
Miyazaki, S | 1 |
Saitoh, A | 1 |
Hirtz, R | 1 |
Libuda, L | 1 |
Hinney, A | 1 |
Föcker, M | 1 |
Bühlmeier, J | 1 |
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Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Randomized, Double-Blinded, Placebo-Controlled Study Evaluating Vortioxetine for Cognitive Deficits in Persons With Post-COVID-19 Condition[NCT05047952] | Phase 2 | 200 participants (Actual) | Interventional | 2021-09-16 | Completed | ||
Cannabidiol for Treatment Resistant Depression[NCT04732169] | Phase 4 | 0 participants (Actual) | Interventional | 2021-07-01 | Withdrawn (stopped due to Investigator decided not to do study, due to insufficient funding.) | ||
Perinatal Stress and Gene Influences: Pathways to Infant Vulnerability[NCT00525226] | 1,431 participants (Actual) | Observational | 2007-09-30 | Completed | |||
The Effect of Therapeutic Ketamine Infusions on the Symptoms of Post-Traumatic Stress Disorder in Combat Veterans[NCT03088384] | 30 participants (Actual) | Observational | 2016-11-28 | Completed | |||
Understanding the Neurocognitive Effects of Fecal Microbiota Transplantation in Major Depressive Disorder Patients With and Without Irritable Bowel Syndrome[NCT05174273] | Phase 2/Phase 3 | 180 participants (Anticipated) | Interventional | 2022-04-06 | Recruiting | ||
"Proof-of-Concept Stress & Anxiety Dampening Effects of Lpc-37"[NCT03494725] | 120 participants (Actual) | Interventional | 2018-04-10 | Completed | |||
Randomized Controlled Experimental Trial Designed to Test the Effects of Probiotics on Mood[NCT03539263] | 39 participants (Actual) | Interventional | 2016-12-20 | Completed | |||
The Safety and Effectiveness of Probiotic Supplementation on Bipolar Depression: a Proof of Concept Randomized Controlled Trial[NCT02155972] | Phase 2 | 16 participants (Actual) | Interventional | 2013-05-31 | Terminated (stopped due to The trial was terminated because of inability to recruit the needed number of participants) | ||
A Randomized Controlled Trial of the Safety and Efficacy of Fecal Microbiota Transplantation in a Population With Bipolar Disorder[NCT03279224] | Phase 2/Phase 3 | 35 participants (Actual) | Interventional | 2018-01-01 | Active, not recruiting | ||
Examining the Effects of a Team-based Running Program on the Mental Health and Cognition of Emerging Adults: A Pilot Study[NCT03143582] | 30 participants (Actual) | Interventional | 2017-01-31 | Completed | |||
Probiotics and the Microbiome: Clinical Intervention Trial for Anxiety and Depression[NCT02035878] | Phase 2 | 75 participants (Actual) | Interventional | 2012-08-31 | Active, not recruiting | ||
Role of the Gut Microbiome as Determinant of Depression in Multiple Sclerosis Subjects[NCT05808101] | 120 participants (Anticipated) | Observational | 2022-01-27 | Recruiting | |||
The Effect of Probiotic Supplementation in Drug-resistant Epilepsy Patients[NCT03403907] | 45 participants (Actual) | Interventional | 2014-10-01 | Completed | |||
Role of the Gut Microbiome in Complex Regional Pain Syndrome[NCT03612193] | 140 participants (Anticipated) | Observational | 2018-12-19 | Recruiting | |||
Acute and Chronic Impacts of Muscadine Wine Polyphenols on Cognition, Memory, Mood, and Anxiety in Adults Over 50 Years of Age[NCT05541887] | 25 participants (Anticipated) | Interventional | 2023-08-30 | Recruiting | |||
A Clinical Trial to Evaluate the Safety and Tolerability of Fecal Microbiota Transplantation in a Population With Obsessive-compulsive Disorder[NCT05720793] | Phase 2 | 20 participants (Anticipated) | Interventional | 2023-06-01 | Recruiting | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Efficacy of the intake of Lpc-37 on reduction of the increase of the diastolic BP in response to the TSST compared to placebo. (NCT03494725)
Timeframe: 3 minutes before the TSST and 1 minute after the TSST after 5 weeks of study product intake
Intervention | mmHg (Mean) | |
---|---|---|
Pre-TSST -3min | Post-TSST +1min | |
Lpc-37 | 79.13 | 90.38 |
Placebo | 78.41 | 88.36 |
"Efficacy of the intake of Lpc-37 on the increase of mood scale scores over the course of the treatment~Measured with a daily online diary. Mood was rated by participants on an 11-point scale (0-10; very bad to very well) and monitored through the washout phase (week 1 and 2) and the subsequent treatment phase (weeks 3-7). Higher scores indicate a better mood. Efficacy is defined as an increase, or (in case of a general decrease) reduced decrease for the active treatment group as compared to the placebo group and operationalized as the interaction between time and treatment group. Time is coded as a continuous variable with one average value for each week and participant. Values reflect summary measures for mood ratings on a scale from 0 to 10 for the averaged ratings per participant and week." (NCT03494725)
Timeframe: Daily for 2 weeks before treatment intake and 5 weeks during treatment intake
Intervention | score (Mean) | ||||||
---|---|---|---|---|---|---|---|
Week 1 (run-in) | Week 2 (run-in) | Week 3 (treatment) | Week 4 (treatment) | Week 5 (treatment) | Week 6 (treatment) | Week 7 (treatment) | |
Lpc-37 | 7.31 | 7.53 | 7.66 | 7.77 | 7.73 | 7.90 | 7.77 |
Placebo | 7.27 | 7.49 | 7.46 | 7.53 | 7.50 | 7.40 | 7.55 |
"Efficacy of the intake of Lpc-37 on the increase of perceived health status scores over the course of the treatment.~Measured with a daily online diary. Health status was rated by participants on an 11-point scale (0-10; not at all to very) and monitored through the wash-out phase (week 1 and 2) and the subsequent treatment phase (weeks 3-7). Higher scores indicate a high perceived health.Efficacy is defined as an increase, or (in case of a general decrease) reduced decrease for the active treatment group as compared to the placebo group and operationalized as the interaction between time and treatment group. Time is coded as a continuous variable with one value for each day and participant. Values reflect summary measures for perceived health status on a scale from 0 to 10 for the averaged ratings per participant and week." (NCT03494725)
Timeframe: Daily for 2 weeks before treatment intake and 5 weeks during treatment intake
Intervention | score (Mean) | ||||||
---|---|---|---|---|---|---|---|
Week 1 (run-in) | Week 2 (run-in) | Week 3 (treatment) | Week 4 (treatment) | Week 5 (treatment) | Week 6 (treatment) | Week 7 (treatment) | |
Lpc-37 | 7.80 | 7.89 | 7.88 | 7.91 | 8.05 | 8.11 | 7.91 |
Placebo | 7.86 | 7.92 | 7.92 | 8.01 | 7.92 | 7.73 | 7.75 |
"Efficacy of the intake of Lpc-37 on the increase of perceived productivity scores over the course of the treatment~Measured with a daily online diary. Productivity was rated by participants on an 11-point scale (0-10; not at all to very) and monitored through the wash-out phase (week 1 and 2) and the subsequent treatment phase (weeks 3-7). Higher scores indicate a higher perceived productivity. Efficacy is defined as an increase, or (in case of a general decrease) reduced decrease for the active treatment group as compared to the placebo group and operationalized as the interaction between time and treatment group.Time is coded as a continuous variable with one value for each day and participant. The values reflect summary measures for perceived productivity on a scale from 0 to 10 for the averaged ratings per participant and week." (NCT03494725)
Timeframe: Daily for 2 weeks before treatment intake and 5 weeks during treatment intake
Intervention | score (Mean) | ||||||
---|---|---|---|---|---|---|---|
Week 1 (run-in) | Week 2 (run-in) | Week 3 (treatment) | Week 4 (treatment) | Week 5 (treatment) | Week 6 (treatment) | Week 7 (treatment) | |
Lpc-37 | 6.98 | 7.34 | 7.53 | 7.48 | 7.59 | 7.57 | 7.50 |
Placebo | 7.15 | 7.29 | 7.30 | 7.34 | 7.43 | 7.31 | 7.32 |
"Efficacy of the intake of Lpc-37 on the decrease of reported number of sleep disruptions over the course of the treatment measured with a daily online diary (mean of week summary).~Sleep disruptions were monitored through the wash-out phase (Week 1 and 2) and the subsequent treatment phase (Weeks 3-7). In the count version, the value can be 0 or a natural number for each day and each participant. Efficacy is defined as a decrease, or (in case of a general increase) reduced increase for the active treatment group as compared to the placebo group and operationalized as the interaction between time and treatment group. Time is coded as a continuous variable with one value for each day and participant. Values reflect summary measures for sleep disruptions (count) for the summed counts per participant and week." (NCT03494725)
Timeframe: Daily for 2 weeks before treatment intake and 5 weeks during treatment intake
Intervention | sleep disruptions per participant & week (Mean) | ||||||
---|---|---|---|---|---|---|---|
Week 1 (run-in) | Week 2 (run-in) | Week 3 (treatment) | Week 4 (treatment) | Week 5 (treatment) | Week 6 (treatment) | Week 7 (treatment) | |
Lpc-37 | 7.30 | 5.50 | 4.89 | 5.43 | 3.52 | 3.80 | 4.66 |
Placebo | 6.09 | 5.49 | 5.11 | 4.30 | 3.53 | 4.02 | 5.83 |
"Efficacy of the intake of Lpc-37 on the decrease of sleep disruptions over the course of the treatment measured with a daily online diary (Proportion (yes/total)).~Sleep disruptions were monitored through the wash-out phase and the subsequent treatment phase for each week. In the binary version, the value is either Yes or No for each day and each participant.~Efficacy is defined as a decrease, or (in case of a general increase) reduced increase for the active treatment group as compared to the placebo group and operationalized as the interaction between time and treatment group. Time is coded as a continuous variable with one value for each day and participant.~The proportion of participants with at least one sleep disruption by treatment group is given, treatment commenced after week 2. Data listed here reflect the proportion of participants who answered Yes (e.g. 0,477 * 44 = 20.99 participants answered with Yes in week 1 in the Lpc-37 group)." (NCT03494725)
Timeframe: Daily for 2 weeks before treatment intake and 5 weeks during treatment intake
Intervention | Proportion of participants (yes/total) (Number) | ||||||
---|---|---|---|---|---|---|---|
Week 1 (run-in) | Week 2 (run-in) | Week 3 (treatment) | Week 4 (treatment) | Week 5 (treatment) | Week 6 (treatment) | Week 7 (treatment) | |
Lpc-37 | 0.477 | 0.435 | 0.354 | 0.367 | 0.306 | 0.279 | 0.290 |
Placebo | 0.465 | 0.426 | 0.418 | 0.310 | 0.292 | 0.331 | 0.389 |
Efficacy of the intake of Lpc-37 on reduction of the increase of salivary Alpha-Amylase (sAA) in response to the TSST compared to placebo. (NCT03494725)
Timeframe: 1 minute before the TSST and 1, 10, 20, 30 and 45 minutes after the TSST after 5 weeks of study product intake
Intervention | U/ml (Mean) | |||||
---|---|---|---|---|---|---|
Pre-TSST -2min | Post-TSST +1min | Post-TSST +10min | Post-TSST +20min | Post-TSST +30min | Post-TSST +45min | |
Lpc-37 | 154.04 | 246.29 | 146.53 | 130.11 | 125.19 | 141.13 |
Placebo | 161.67 | 270.55 | 158.85 | 141.49 | 138.48 | 148.15 |
Efficacy of the intake of Lpc-37 on reduction of the increase of salivary cortisol in response to the TSST compared to placebo. (NCT03494725)
Timeframe: 1 minute before the TSST and 1, 10, 20, 30 and 45 minutes after the TSST after 5 weeks of study product intake
Intervention | nmol/L (Mean) | |||||
---|---|---|---|---|---|---|
Pre-TSST -2min | Post-TSST +1min | Post-TSST +10min | Post-TSST +20min | Post-TSST +30min | Post-TSST +45min | |
Lpc-37 | 4.79 | 6.96 | 9.48 | 9.89 | 8.04 | 6.21 |
Placebo | 4.82 | 6.85 | 8.97 | 9.21 | 7.71 | 6.16 |
"Efficacy of the intake of Lpc-37 on the increase of sleep duration over the course of the treatment.~Sleep duration was monitored through the wash-out phase (week 1 and 2) and the subsequent treatment phase (weeks 3-7). Efficacy is defined as an increase, or (in case of a general decrease) reduced decrease for the active treatment group as compared to the placebo group and operationalized as the interaction between time and treatment group. Time is coded as a continuous variable with one value for each day and participant. Summary measures for Sleep duration for the averaged ratings per participant and week" (NCT03494725)
Timeframe: Daily for 2 weeks before treatment intake and 5 weeks during treatment intake
Intervention | min (Mean) | ||||||
---|---|---|---|---|---|---|---|
Week 1 (run-in) | Week 2 (run-in) | Week 3 (treatment) | Week 4 (treatment) | Week 5 (treatment) | Week 6 (treatment) | Week 7 (treatment) | |
Lpc-37 | 447.27 | 444.01 | 449.45 | 450.62 | 454.50 | 450.88 | 445.60 |
Placebo | 447.45 | 448.13 | 456.90 | 459.81 | 457.26 | 450.16 | 459.66 |
"Efficacy of the intake of Lpc-37 on the increase of sleep related recovery scores over the course of the treatment.~Measured with a daily online diary. Sleep related recovery was rated by participants on an 11-point scale (0-10; not at all to very) and monitored throughout the wash-out phase (Week 1 and 2) and the subsequent treatment phase (weeks 3-7). High scores indicate a high recovery.~Efficacy is defined as an increase, or (in case of a general decrease) reduced decrease for the active treatment group as compared to the placebo group and operationalized as the interaction between time and treatment group. Time is coded as a continuous variable with one value for each day and participant. Summary measures for sleep related recovery for the averaged ratings per participant and week." (NCT03494725)
Timeframe: Daily for 2 weeks before treatment intake and 5 weeks during treatment intake
Intervention | score (Mean) | ||||||
---|---|---|---|---|---|---|---|
Week 1 (run-in) | Week 2 (run-in) | Week 3 (treatment) | Week 4 (treatment) | Week 5 (treatment) | Week 6 (treatment) | Week 7 (treatment) | |
Lpc-37 | 6.71 | 7.07 | 7.32 | 7.30 | 7.36 | 7.42 | 7.31 |
Placebo | 6.91 | 7.15 | 7.27 | 7.29 | 7.36 | 7.10 | 7.28 |
"Efficacy of the intake of Lpc-37 on reduction of the increase of STAI-State scores in response to the TSST compared to placebo.~Measured with the german version of the State-Trait-Anxiety Inventory, scale anxiety as a temporary emotional state (STAI-X1). Answers are given on a four-point rating scale ranging from 1=not at all to 4=very true. The score range is 20-80; Higher scores indicate more anxiety." (NCT03494725)
Timeframe: 10 minutes before the TSST and 1 minute after the TSST after 5 weeks of study product intake
Intervention | score (Mean) | |
---|---|---|
Pre-TSST -10min | Post-TSST +1min | |
Lpc-37 | 36.09 | 42.38 |
Placebo | 36.83 | 43.60 |
Efficacy of the intake of Lpc-37 on reduction of the increase of the systolic BP in response to the TSST compared to placebo. (NCT03494725)
Timeframe: 3 minutes before the TSST and 1 minute after the TSST after 5 weeks of study product intake
Intervention | mmHg (Mean) | |
---|---|---|
Pre-TSST -3min | Post-TSST +1min | |
Lpc-37 | 115.11 | 127.47 |
Placebo | 114.33 | 129.19 |
Efficacy was defined as a lower increase in HR in response to the TSST following intervention with Lpc-37, compared to placebo. (NCT03494725)
Timeframe: Continuous measurement starting 20 minutes before and ending 20 minutes after the TSST after 5 weeks of product intake. Mean values were calculated per group at seven-time windows before, during and after the TSST
Intervention | bpm (Mean) | ||||||
---|---|---|---|---|---|---|---|
Pre-TSST -20min | Pre-TSST -10min | Pre-TSST -3min | during TSST (Interview) | during TSST (Arithmetic) | Post-TSST +10min | Post-TSST +20min | |
Lpc-37 | 74.84 | 88.15 | 97.34 | 107.56 | 102.77 | 93.32 | 75.88 |
Placebo | 74.34 | 86.69 | 97.62 | 105.66 | 100.81 | 90.81 | 74.97 |
"Efficacy of the intake of Lpc-37 on reduction of the increase of VAS anxiety scores in response to the TSST compared to placebo.~Measured with a german version of the Visual Analog Scale (VAS) as a 10cm bipolar scale ranging from not at all to highly. The participant indicated his/her actual perception by placing a mark on a line. VAS scores were obtained by using a ruler and measuring the position of the participants's mark with millimeter precision. To control for possible variations due to printing, the total length of the line was also measured and percentage scores for each participant were computed. Percentage scores range from 0-100. Higher scores indicating greater anxiety." (NCT03494725)
Timeframe: 10 minutes before the TSST, during the TSST and 1 minute after the TSST after 5 weeks of study product intake
Intervention | score (Mean) | ||
---|---|---|---|
Pre-TSST -10min | Interview TSST (during) | Post-TSST +1min | |
Lpc-37 | 6.80 | 20.85 | 10.68 |
Placebo | 8.50 | 22.47 | 11.74 |
"Efficacy of the intake of Lpc-37 on reduction of the increase of VAS exhaustion scores in response to the TSST compared to placebo.~Measured with a german version of the Visual Analog Scale (VAS) as a 10cm bipolar scale ranging from not at all to highly. The participant indicated his/her actual perception by placing a mark on a line. VAS scores were obtained by using a ruler and measuring the position of the participants's mark with millimeter precision. To control for possible variations due to printing, the total length of the line was also measured and percentage scores for each participant were computed. Percentage scores range from 0-100. Higher scores indicating greater exhaustion." (NCT03494725)
Timeframe: 10 minutes before the TSST, during the TSST and 1 minute after the TSST after 5 weeks of study product intake
Intervention | score (Mean) | ||
---|---|---|---|
Pre-TSST -10min | Interview TSST (during) | Post-TSST +1min | |
Lpc-37 | 21.18 | 19.20 | 22.12 |
Placebo | 19.79 | 21.30 | 25.68 |
"Efficacy of the intake of Lpc-37 on reduction of the increase of VAS insecurity scores in response to the TSST compared to placebo.~Measured with a german version of the Visual Analog Scale (VAS) as a 10cm bipolar scale ranging from not at all to highly. The participant indicated his/her actual perception by placing a mark on a line. VAS scores were obtained by using a ruler and measuring the position of the participants's mark with millimeter precision. To control for possible variations due to printing, the total length of the line was also measured and percentage scores for each participant were computed. Percentage scores range from 0-100. Higher scores indicating greater insecurity." (NCT03494725)
Timeframe: 10 minutes before the TSST, during the TSST and 1 minute after the TSST after 5 weeks of study product intake
Intervention | score (Mean) | ||
---|---|---|---|
Pre-TSST -10min | Interview TSST (during) | Post-TSST +1min | |
Lpc-37 | 14.47 | 45.08 | 23.92 |
Placebo | 17.19 | 52.19 | 23.69 |
"Efficacy of the intake of Lpc-37 on reduction of the increase of VAS Stress perception scores in response to the TSST compared to placebo.~Measured with a german version of the Visual Analog Scale (VAS) as a 10cm bipolar scale ranging from not at all to highly. The participant indicated his/her actual perception by placing a mark on a line. VAS scores were obtained by using a ruler and measuring the position of the participants's mark with millimeter precision. To control for possible variations due to printing, the total length of the line was also measured and percentage scores for each participant were computed. Percentage scores range from 0-100. Higher scores indicating higher perceived stress." (NCT03494725)
Timeframe: 10 minutes before the TSST, during the TSST and 1 minute after the TSST after 5 weeks of study product intake
Intervention | score (Mean) | ||
---|---|---|---|
Pre-TSST -10min | Interview TSST (during) | Post-TSST +1min | |
Lpc-37 | 19.89 | 47.71 | 31.72 |
Placebo | 18.52 | 51.51 | 32.85 |
"Efficacy of the intake of Lpc-37 on the reduction of Beck Anxiety Inventory (BAI) scores compared to placebo.~Measured with the german version of the Beck Anxiety Inventory as a self-rating scale designed to measure anxiety. It comprises 21 sentences describing feelings that can occur when being anxious. These sentences are rated on a four-point rating scale ranging from 0=not at all to 3=severely, considering the last 7 days. The score range is 0-63; Higher scores indicate higher anxiety." (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.
Intervention | score (Mean) | |
---|---|---|
Baseline | End of Study | |
Lpc-37 | 5.51 | 4.75 |
Placebo | 5.85 | 6.33 |
"Efficacy of the intake of Lpc-37 on the reduction of Depression Anxiety Stress Scale (DASS) anxiety scores compared to placebo.~Measured with the german version of the DASS as a 42-item self report instrument designed to measure negative emotional states of depression, anxiety and stress during the past week. The DASS includes three scales (depression, anxiety and stress) of which each scale includes 14 items that are divided into subscales of 2-5 items of similar content.~Items are answered on a four point rating scale ranging from 0 = not at all to 3 = very much. Scores of each scale are calculated by summing the scores for the relevant items.~The anxiety scale assesses autonomic arousal, skeletal muscle effects, situational anxiety, and subjective experience of anxious affect. The items are 2, 4, 7, 9, 15, 19, 20, 23, 25, 28, 30, 36, 40, 41 and individual scores can range from 0 to 42 with higher scores indicating greater severity of the symptoms." (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.
Intervention | score (Mean) | |
---|---|---|
Baseline | End of Study | |
Lpc-37 | 2.60 | 2.44 |
Placebo | 3.07 | 3.45 |
"Efficacy of the intake of Lpc-37 on the reduction of Depression Anxiety Stress Scale (DASS) depression scores compared to placebo.~Measured with the german version of the DASS as a 42-item self report instrument designed to measure negative emotional states of depression, anxiety and stress during the past week. The DASS includes three scales (depression, anxiety and stress) of which each scale includes 14 items that are divided into subscales of 2-5 items of similar content.~Items are answered on a four point rating scale ranging from 0 = not at all to 3 = very much. Scores of each scale are calculated by summing the scores for the relevant items.~The Depression scale assesses dysphoria, hopelessness, devaluation of life, self-deprecation, lack of interest/involvement, anhedonia, and inertia. The items are 3, 5, 10, 13, 16, 17, 21, 24, 26, 31, 34, 37, 38, 42 and individual scores can range from 0 to 42 with higher scores indicating greater severity of the symptoms." (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.
Intervention | score (Mean) | |
---|---|---|
Baseline | End of Study | |
Lpc-37 | 4.60 | 4.15 |
Placebo | 5.21 | 5.10 |
"Efficacy of the intake of Lpc-37 on the reduction of Depression Anxiety Stress Scale (DASS) stress scores compared to placebo.~Measured with the german version of the DASS as a 42-item self report instrument designed to measure negative emotional states of depression, anxiety and stress during the past week. The DASS includes three scales (depression, anxiety and stress) of which each scale includes 14 items that are divided into subscales of 2-5 items of similar content.~Items are answered on a four point rating scale ranging from 0 = not at all to 3 = very much. Scores of each scale are calculated by summing the scores for the relevant items.~The stress scale (items) is sensitive to levels of chronic non-specific arousal.The stress scale items are 1, 6, 8, 11, 12, 14, 18, 22, 27, 29, 32, 33, 35, 39 and individual scores can range from 0 to 42 with higher scores indicating greater severity of the symptoms." (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.
Intervention | score (Mean) | |
---|---|---|
Baseline | End of Study | |
Lpc-37 | 9.76 | 8.91 |
Placebo | 9.41 | 10.09 |
Efficacy of the intake of Lpc-37 on the reduction of diastolic BP. (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.
Intervention | mmHg (Mean) | |
---|---|---|
Baseline | End of Study | |
Lpc-37 | 71.89 | 73.18 |
Placebo | 71.68 | 74.62 |
"Efficacy of the intake of Lpc-37 on the reduction of Perceived Stress Scale (PSS) scores compared to placebo.~Measured with the german version of the PSS as a psychological instrument for measuring stress perception. It assesses how unpredictable, uncontrollable and overloaded participants perceived their lives to have been within the last month. The PSS comprises 14 items that are answered on a five-point rating scale ranging from 0 = never to 4 = very often. Individual scores on the PSS can range from 0 to 56 with higher scores indicating higher perceived stress." (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.
Intervention | score (Mean) | |
---|---|---|
Baseline | End of Study | |
Lpc-37 | 21.89 | 20.49 |
Placebo | 20.72 | 21.56 |
"Efficacy of the intake of Lpc-37 on the reduction of State-Trait-Anxiety-Inventory (STAI)-state scores compared to placebo.~Measured with the german version of the State-Trait-Anxiety Inventory, scale anxiety as a temporary emotional state (STAI-X1). Answers are given on a four-point rating scale ranging from 1=not at all to 4=very true. The score range is 20-80; Higher scores indicate more anxiety." (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.
Intervention | score (Mean) | |
---|---|---|
Baseline | End of Study | |
Lpc-37 | 33.65 | 35.18 |
Placebo | 34.33 | 35.33 |
Efficacy of the intake of Lpc-37 on the reduction of systolic blood pressure (BP). (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.
Intervention | mmHg (Mean) | |
---|---|---|
Baseline | End of Study | |
Lpc-37 | 119.60 | 121.87 |
Placebo | 119.66 | 122.86 |
"Efficacy of the intake of Lpc-37 on the reduction of VAS anxiety scores compared to placebo.~Measured with a german version of the Visual Analog Scale (VAS) as a 10cm bipolar scale ranging from not at all to highly. The participant indicated his/her actual perception by placing a mark on a line. VAS scores were obtained by using a ruler and measuring the position of the participants's mark with millimeter precision. To control for possible variations due to printing, the total length of the line was also measured and percentage scores for each participant were computed. Percentage scores range from 0-100. Higher scores indicating greater anxiety." (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.
Intervention | score (Mean) | |
---|---|---|
Baseline | End of Study | |
Lpc-37 | 7.29 | 9.26 |
Placebo | 7.58 | 7.85 |
"Efficacy of the intake of Lpc-37 on the reduction of VAS exhaustion scores compared to placebo.~Measured with a german version of the Visual Analog Scale (VAS) as a 10cm bipolar scale ranging from not at all to highly. The participant indicated his/her actual perception by placing a mark on a line. VAS scores were obtained by using a ruler and measuring the position of the participants's mark with millimeter precision. To control for possible variations due to printing, the total length of the line was also measured and percentage scores for each participant were computed. Percentage scores range from 0-100. Higher scores indicating greater exhaustion." (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.
Intervention | score (Mean) | |
---|---|---|
Baseline | End of Study | |
Lpc-37 | 29.56 | 24.66 |
Placebo | 23.19 | 18.45 |
"Efficacy of the intake of Lpc-37 on the reduction of VAS insecurity scores compared to placebo.~Measured with a german version of the Visual Analog Scale (VAS) as a 10cm bipolar scale ranging from not at all to highly. The participant indicated his/her actual perception by placing a mark on a line. VAS scores were obtained by using a ruler and measuring the position of the participants's mark with millimeter precision. To control for possible variations due to printing, the total length of the line was also measured and percentage scores for each participant were computed. Percentage scores range from 0-100. Higher scores indicating greater insecurity." (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.
Intervention | score (Mean) | |
---|---|---|
Baseline | End of Study | |
Lpc-37 | 13.58 | 16.44 |
Placebo | 15.91 | 17.30 |
"Efficacy of the intake of Lpc-37 on the reduction of Visual Analog Scale (VAS) stress perception scores compared to placebo.~Measured with a german version of the Visual Analog Scale (VAS) as a 10cm bipolar scale ranging from not at all to highly. The participant indicated his/her actual perception by placing a mark on a line. VAS scores were obtained by using a ruler and measuring the position of the participants's mark with millimeter precision. To control for possible variations due to printing, the total length of the line was also measured and percentage scores for each participant were computed. Percentage scores range from 0-100. Higher scores indicating higher perceived stress." (NCT03494725)
Timeframe: Before and after 5 weeks of study product intake.
Intervention | score (Mean) | |
---|---|---|
Baseline | End of Study | |
Lpc-37 | 19.11 | 23.32 |
Placebo | 19.34 | 20.67 |
"Efficacy of the intake of Lpc-37 on the reduction of the difference of cortisol at 8 pm values to the respective mean before and after 5 weeks of treatment~Efficacy for the CAR variable cortisol at 8 pm is defined in terms of a normalization: Number of participants with normal values (between first and third quantile of reference measures) and numbers of participants with low or high values are compared before treatment and after treatment. More participants in the normal range after treatment is defined as efficacy." (NCT03494725)
Timeframe: Baseline (average of 2 days before first product intake) and end of study (average of 2 days before last product intake
Intervention | number of participants (Number) | |||||
---|---|---|---|---|---|---|
Baseline (<25% quantile) | Baseline (25% - 75% quantile) | Baseline (>75% quantile) | End of Study (<25% quantile) | End of Study (25% - 75% quantile) | End of Study (>75% quantile) | |
Lpc-37 | 4 | 20 | 29 | 3 | 28 | 22 |
Placebo | 6 | 23 | 26 | 7 | 18 | 30 |
"Efficacy of the intake of Lpc-37 on the reduction of the difference of Cortisol Awakening Response (CAR) area under the curve with respect to the ground (AUCg) values to the respective mean before and after 5 weeks of treatment.~The CAR is summarized in the variables AUCg, AUCi, mean increase and peak value. These cortisol indices are frequently used to describe hypothalamic-pituitary-adrenal axis activity and represent information either of the total cortisol production or of the change in cortisol levels. AUCg is the total area under the curve of all measurements (i.e., the intensity or magnitude of the response).~Efficacy for the CAR variables AUCg is defined in terms of a normalization: Number of participants with normal values (between first and third quantile of reference measures) and numbers of participants with low or high values are compared before treatment and after treatment. More participants in the normal range after treatment is defined as efficacy." (NCT03494725)
Timeframe: Baseline (average of 2 days before first product intake) and end of study (average of 2 days before last product intake)
Intervention | number of participants (Number) | |||||
---|---|---|---|---|---|---|
Baseline (<25% quantile) | Baseline (25% - 75% quantile) | Baseline (>75% quantile) | End of Study (<25% quantile) | End of Study (25% - 75% quantile) | End of Study (>75% quantile) | |
Lpc-37 | 6 | 36 | 11 | 11 | 28 | 14 |
Placebo | 12 | 30 | 13 | 7 | 35 | 13 |
"Efficacy of the intake of Lpc-37 on the reduction of the difference of Cortisol at Awakening values to the respective mean before and after 5 weeks of treatment~Efficacy for the CAR variable cortisol at awakening is defined in terms of a normalization: Number of participants with normal values (between first and third quantile of reference measures) and numbers of participants with low or high values are compared before treatment and after treatment. More participants in the normal range after treatment is defined as efficacy." (NCT03494725)
Timeframe: Baseline (average of 2 days before first product intake) and end of study (average of 2 days before last product intake)
Intervention | number of participants (Number) | |||||
---|---|---|---|---|---|---|
Baseline (<25% quantile) | Baseline (25% - 75% quantile) | Baseline (>75% quantile) | End of Study (<25% quantile) | End of Study (25% - 75% quantile) | End of Study (>75% quantile) | |
Lpc-37 | 14 | 31 | 8 | 19 | 26 | 8 |
Placebo | 16 | 26 | 13 | 12 | 34 | 9 |
"Efficacy of the intake of Lpc-37 on the reduction of the difference of CAR area under the curve with respect to the increase (AUCi) values to the respective mean before and after the treatment.~The CAR is summarized in the variables AUCg, AUCi, mean increase and peak value. These cortisol indices are frequently used to describe hypothalamic-pituitary-adrenal axis activity and represent information either of the total cortisol production or of the change in cortisol levels. AUCi is calculated with reference to the baseline measurement and it ignores the distance from zero for all measurements and emphasizes the changes over time. Efficacy for the CAR variables AUCi is defined in terms of a normalization: Number of participants with normal values (between first and third quantile of reference measures) and numbers of participants with low or high values are compared before treatment and after treatment. More participants in the normal range after treatment is defined as efficacy." (NCT03494725)
Timeframe: Baseline (average of 2 days before first product intake) and end of study (average of 2 days before last product intake)
Intervention | number of participants (Number) | |||||
---|---|---|---|---|---|---|
Baseline (<25% quantile) | Baseline (25% - 75% quantile) | Baseline (>75% quantile) | End of Study (<25% quantile) | End of Study (25% - 75% quantile) | End of Study (>75% quantile) | |
Lpc-37 | 16 | 34 | 3 | 15 | 34 | 4 |
Placebo | 22 | 28 | 5 | 15 | 36 | 4 |
6 reviews available for corticosterone and Depression
Article | Year |
---|---|
Do corticosterone levels predict female depressive-like behavior in rodents?
Topics: Animals; Behavior, Animal; Biomarkers; Corticosterone; Depression; Disease Models, Animal; Female; M | 2021 |
Stress and Depression: a Crucial Role of the Mineralocorticoid Receptor.
Topics: Adaptation, Psychological; Animals; Antidepressive Agents; Brain; Corticosterone; Depression; Fludro | 2016 |
Oxidative and nitrosative stress pathways in the brain of socially isolated adult male rats demonstrating depressive- and anxiety-like symptoms.
Topics: Animals; Antioxidants; Anxiety; Apoptosis; Brain; Corticosterone; Depression; Hippocampus; Hypothala | 2017 |
Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction.
Topics: Animals; Biomarkers; Cardiovascular Diseases; Corticosterone; Cushing Syndrome; Depression; Glucocor | 2012 |
Neurotransmitter studies of neuroendocrine pathology in depression.
Topics: Acetylcholine; Adolescent; Animals; Brain; Cinanserin; Circadian Rhythm; Corticosterone; Cushing Syn | 1980 |
[Electrophysiologic tests for testing the effects of antidepressant drugs and corticosterone on reactivity of serotonin receptors in the hippocampus].
Topics: Animals; Antidepressive Agents; Corticosterone; Depression; Electrophysiology; Hippocampus; Humans; | 2000 |
1 trial available for corticosterone and Depression
Article | Year |
---|---|
Effect of corticosterone and hydrocortisone on some indicators of anxiety.
Topics: Adrenal Glands; Adult; Analysis of Variance; Anxiety; Clinical Trials as Topic; Computers; Corticost | 1971 |
856 other studies available for corticosterone and Depression
Article | Year |
---|---|
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Cholin | 2018 |
New 2-Pyrazoline and Hydrazone Derivatives as Potent and Selective Monoamine Oxidase A Inhibitors.
Topics: Animals; Antidepressive Agents; Depression; Hep G2 Cells; Humans; Hydrazones; Mice; Molecular Dockin | 2021 |
Neuroprotective effects of macamide from maca (
Topics: Alkenes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Behavior, Animal; | 2021 |
Anti-depressive effects of Jiao-Tai-Wan on CORT-induced depression in mice by inhibiting inflammation and microglia activation.
Topics: Animals; Animals, Outbred Strains; Antidepressive Agents; Behavior, Animal; Corticosterone; Depressi | 2022 |
Behavioral and Neurochemical Changes in Rats with Recurrent Depression induced by chronic unpredictable stress.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Chro | 2021 |
miR-182 mediated the inhibitory effects of NF-κB on the GPR39/CREB/BDNF pathway in the hippocampus of mice with depressive-like behaviors.
Topics: Animals; Brain-Derived Neurotrophic Factor; Computational Biology; Corticosterone; Cyclic AMP Respon | 2022 |
Effects of Importin α1/KPNA1 deletion and adolescent social isolation stress on psychiatric disorder-associated behaviors in mice.
Topics: alpha Karyopherins; Animals; Anxiety; Behavior, Animal; Chemokine CXCL5; Corticosterone; Depression; | 2021 |
Transcranial Direct Current Stimulation Reduces Anxiety, Depression and Plasmatic Corticosterone in a Rat Model of Atypical Generalized Epilepsy.
Topics: Animals; Anxiety; Corticosterone; Depression; Epilepsy, Absence; Humans; Rats; Rats, Wistar; Transcr | 2022 |
Lipoic acid prevents mirtazapine-induced weight gain in mice without impairs its antidepressant-like action in a neuroendocrine model of depression.
Topics: Animals; Antidepressive Agents; Antioxidants; Behavior, Animal; Cognitive Dysfunction; Corticosteron | 2022 |
Galanin (1-15) Enhances the Behavioral Effects of Fluoxetine in the Olfactory Bulbectomy Rat, Suggesting a New Augmentation Strategy in Depression.
Topics: Animals; Antidepressive Agents; Corticosterone; Depression; Fluoxetine; Galanin; Humans; Peptide Fra | 2022 |
Alteration of the α5 GABA receptor and 5HTT lead to cognitive deficits associated with major depressive-like behaviors in a 14-day combined stress rat model.
Topics: Acetylcholinesterase; Animals; Cognition; Corticosterone; Depression; Depressive Disorder, Major; Di | 2023 |
Cinnamaldehyde prevents intergenerational effect of paternal depression in mice via regulating GR/miR-190b/BDNF pathway.
Topics: Acrolein; Animals; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Fathers; Hippocamp | 2022 |
Topics: Animals; Brain-Derived Neurotrophic Factor; Connexin 43; Corticosterone; Depression; Disease Models, | 2022 |
The Effect of Early Life Stress on Emotional Behaviors in GPR37KO Mice.
Topics: Animals; Anxiety; Avoidance Learning; Behavior, Animal; Body Weight; Brain; Calcium-Calmodulin-Depen | 2021 |
RNA-seq based transcriptome analysis of ethanol extract of saffron protective effect against corticosterone-induced PC12 cell injury.
Topics: Animals; Cell Survival; Corticosterone; Crocus; Depression; Gene Expression Profiling; Neuroprotecti | 2022 |
Sex-specific contribution of glucocorticoid receptor alpha isoforms to anxiety and depressive-like behavior in mice.
Topics: Animals; Anxiety; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Female; Hippocampus | 2022 |
Maternal separation induced resilience to depression and spatial memory deficit despite intensifying hippocampal inflammatory responses to chronic social defeat stress in young adult male rats.
Topics: Animals; Corticosterone; Depression; Hippocampus; Male; Maternal Deprivation; Memory Disorders; Rats | 2022 |
A New Potential Antidepressant: Dexmedetomidine Alleviates Neuropathic Pain-Induced Depression by Increasing Neurogenesis in the Hippocampus.
Topics: Animals; Antidepressive Agents; Bromodeoxyuridine; Chronic Pain; Corticosterone; Depression; Dexmede | 2022 |
The antidepressant-like effect of formononetin on chronic corticosterone-treated mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; | 2022 |
Lower antidepressant response to fluoxetine is associated with anxiety-like behavior, hippocampal oxidative imbalance, and increase on peripheral IL-17 and IFN-γ levels.
Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Corticosterone; Depression; Disease Model | 2022 |
Something new and something blue: Responses to novelty in a rodent model of depression and epilepsy comorbidity.
Topics: Animals; Anxiety; Comorbidity; Corticosterone; Depression; Disease Models, Animal; Epilepsy; Humans; | 2022 |
Voluntary physical activity increases maternal care and reduces anxiety- and depression-related behaviours during the postpartum period in mice.
Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Female; | 2022 |
Baicalin Coadministration with Lithium Chloride Enhanced Neurogenesis via GSK3β Pathway in Corticosterone Induced PC-12 Cells.
Topics: Antidepressive Agents; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Flavonoids; Gl | 2022 |
Reelin has antidepressant-like effects after repeated or singular peripheral injections.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal | 2022 |
A single dose of ketamine cannot prevent protracted stress-induced anhedonia and neuroinflammation in rats.
Topics: Anhedonia; Animals; Antidepressive Agents; Carrier Proteins; Corticosterone; Depression; Disease Mod | 2022 |
Pharmacological Study on Total Glycosides of Xiebai Protecting against Depression Model.
Topics: Adrenocorticotropic Hormone; Animals; Corticosterone; Depression; Dopamine; Drugs, Chinese Herbal; G | 2022 |
Negative air ion exposure ameliorates depression-like behaviors induced by chronic mild stress in mice.
Topics: Animals; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Ions; Mice; Stress, P | 2022 |
Development of Anxiolytic and Depression-like Behavior in Mice Infected with Mycobacterium lepraemurium.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Corticosterone; Depression; Mice; Mice, Inbred BALB | 2022 |
Early life adversity accelerates epileptogenesis and enhances depression-like behaviors in rats.
Topics: Adverse Childhood Experiences; Animals; Corticosterone; Depression; Disease Models, Animal; Epilepsy | 2022 |
Cerebrolysin® and Environmental Enrichment, Alone or in Combination, Ameliorate Anxiety- and Depressive-Like Behaviors in a Post-Ischemic Depression Model in Mice.
Topics: Amino Acids; Animals; Anxiety; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Diseas | 2022 |
Beneficial effects of prolonged 2-phenylethyl alcohol inhalation on chronic distress-induced anxio-depressive-like phenotype in female mice.
Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Female; Hypo | 2022 |
Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal | 2022 |
High-frequency ultrasound exposure improves depressive-like behavior in an olfactory bulbectomized rat model of depression.
Topics: Animals; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Male; Olfactory Bulb; | 2022 |
The adrenal steroid profile in adolescent depression: a valuable bio-readout?
Topics: Adolescent; Adult; Corticosterone; Depression; Depressive Disorder, Major; Desoxycorticosterone; Fem | 2022 |
Antidepressant effect of Jujuboside A on corticosterone-induced depression in mice.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Corticosterone; Cyclic AMP Respon | 2022 |
Prophylactic administration of rosmarinic acid ameliorates depression-associated cardiac abnormalities in Wistar rats: Evidence of serotonergic, oxidative, and inflammatory pathways.
Topics: Animals; Behavior, Animal; Biomarkers; Catalase; Cinnamates; Copper; Corticosterone; Depression; Dep | 2022 |
Hippocampal miR-124 Participates in the Pathogenesis of Depression via Regulating the Expression of BDNF in a Chronic Social Defeat Stress Model of Depression.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Disea | 2022 |
Icariin Improves Glucocorticoid Resistance in a Murine Model of Asthma with Depression Associated with Enhancement of GR Expression and Function.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Corticosterone; Cytokines; Depression; Disease Models | 2023 |
Loureirin C and Xanthoceraside Prevent Abnormal Behaviors Associated with Downregulation of Brain Derived Neurotrophic Factor and AKT/mTOR/CREB Signaling in the Prefrontal Cortex Induced by Chronic Corticosterone Exposure in Mice.
Topics: Animals; Brain-Derived Neurotrophic Factor; Corticosterone; Cyclic AMP Response Element-Binding Prot | 2022 |
Hippocampal semaphorin 3B improves depression-like behaviours in mice by upregulating synaptic plasticity and inhibiting neuronal apoptosis.
Topics: Animals; Apoptosis; Behavior, Animal; Corticosterone; Depression; Hippocampus; Mice; Neuronal Plasti | 2022 |
Swimming exercise strain-dependently affects maternal care and depression-related behaviors through gestational corticosterone and brain serotonin in postpartum dams.
Topics: Anhedonia; Animals; Brain; Corticosterone; Depression; Depression, Postpartum; Female; Humans; Mater | 2022 |
Brain matrix metalloproteinase-9 activity is altered in the corticosterone mouse model of depression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Depressive Disorder, M | 2023 |
Antibiotics-induced depression in mice via the microbiota-gut-brain axis.
Topics: Adrenocorticotropic Hormone; Animals; Anti-Bacterial Agents; Brain-Derived Neurotrophic Factor; Brai | 2022 |
Mechanistic insights into the protective role of eugenol against stress-induced reproductive dysfunction in female rat model.
Topics: Animals; Antioxidants; Corticosterone; Depression; Disease Models, Animal; Estradiol; Eugenol; Femal | 2022 |
Sex differences in peripheral monoamine transmitter and related hormone levels in chronic stress mice with a depression-like phenotype.
Topics: Androgens; Animals; Corticosterone; Depression; Estrogens; Female; Male; Mice; Mice, Inbred C57BL; N | 2022 |
Antidepressant effects of cherry leaf decoction on a chronic unpredictable mild stress rat model based on the Glu/GABA-Gln metabolic loop.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Corticosterone; Depression; Disease Mod | 2022 |
β-Arrestin2-biased Drd2 agonist UNC9995 alleviates astrocyte inflammatory injury via interaction between β-arrestin2 and STAT3 in mouse model of depression.
Topics: Animals; Astrocytes; beta-Arrestin 1; beta-Arrestin 2; Corticosterone; Depression; Depressive Disord | 2022 |
Paeoniflorin exhibits antidepressant activity in rats with postpartum depression via the TSPO and BDNF‑mTOR pathways.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Carrier Proteins; Corticosterone; | 2022 |
Mahonia Alkaloids (MA) Ameliorate Depression Induced Gap Junction Dysfunction by miR-205/Cx43 Axis.
Topics: Alkaloids; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Connexin 43; Corticost | 2022 |
Resistance Training Modulates Hippocampal Neuroinflammation and Protects Anxiety-Depression-like Dyad Induced by an Emotional Single Prolonged Stress Model.
Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Hippocampus; | 2023 |
18β-Glycyrrhetinic Acid Ameliorates Neuroinflammation Linked Depressive Behavior Instigated by Chronic Unpredictable Mild Stress via Triggering BDNF/TrkB Signaling Pathway in Rats.
Topics: Adrenocorticotropic Hormone; Animals; Body Weight; Brain-Derived Neurotrophic Factor; Corticosterone | 2023 |
Investigating neuropsychological and reward-related deficits in a chronic corticosterone-induced model of depression.
Topics: Animals; Corticosterone; Depression; Depressive Disorder, Major; Judgment; Male; Rats; Reward | 2023 |
Resveratrol exerts anxiolytic-like effects through anti-inflammatory and antioxidant activities in rats exposed to chronic social isolation.
Topics: Animals; Anti-Anxiety Agents; Anti-Inflammatory Agents; Antioxidants; Behavior, Animal; Corticostero | 2023 |
Anti-depressive-like and cognitive impairment alleviation effects of Gastrodia elata Blume water extract is related to gut microbiome remodeling in ApoE
Topics: Animals; Antidepressive Agents; Cognitive Dysfunction; Corticosterone; Depression; Dopamine; Gastrod | 2023 |
The combination of chronic stress and smoke exacerbated depression-like changes and lung cancer factor expression in A/J mice: Involve inflammation and BDNF dysfunction.
Topics: Animals; Antidepressive Agents; bcl-2-Associated X Protein; Brain-Derived Neurotrophic Factor; Corti | 2022 |
The combination of chronic stress and smoke exacerbated depression-like changes and lung cancer factor expression in A/J mice: Involve inflammation and BDNF dysfunction.
Topics: Animals; Antidepressive Agents; bcl-2-Associated X Protein; Brain-Derived Neurotrophic Factor; Corti | 2022 |
The combination of chronic stress and smoke exacerbated depression-like changes and lung cancer factor expression in A/J mice: Involve inflammation and BDNF dysfunction.
Topics: Animals; Antidepressive Agents; bcl-2-Associated X Protein; Brain-Derived Neurotrophic Factor; Corti | 2022 |
The combination of chronic stress and smoke exacerbated depression-like changes and lung cancer factor expression in A/J mice: Involve inflammation and BDNF dysfunction.
Topics: Animals; Antidepressive Agents; bcl-2-Associated X Protein; Brain-Derived Neurotrophic Factor; Corti | 2022 |
The combination of chronic stress and smoke exacerbated depression-like changes and lung cancer factor expression in A/J mice: Involve inflammation and BDNF dysfunction.
Topics: Animals; Antidepressive Agents; bcl-2-Associated X Protein; Brain-Derived Neurotrophic Factor; Corti | 2022 |
The combination of chronic stress and smoke exacerbated depression-like changes and lung cancer factor expression in A/J mice: Involve inflammation and BDNF dysfunction.
Topics: Animals; Antidepressive Agents; bcl-2-Associated X Protein; Brain-Derived Neurotrophic Factor; Corti | 2022 |
The combination of chronic stress and smoke exacerbated depression-like changes and lung cancer factor expression in A/J mice: Involve inflammation and BDNF dysfunction.
Topics: Animals; Antidepressive Agents; bcl-2-Associated X Protein; Brain-Derived Neurotrophic Factor; Corti | 2022 |
The combination of chronic stress and smoke exacerbated depression-like changes and lung cancer factor expression in A/J mice: Involve inflammation and BDNF dysfunction.
Topics: Animals; Antidepressive Agents; bcl-2-Associated X Protein; Brain-Derived Neurotrophic Factor; Corti | 2022 |
The combination of chronic stress and smoke exacerbated depression-like changes and lung cancer factor expression in A/J mice: Involve inflammation and BDNF dysfunction.
Topics: Animals; Antidepressive Agents; bcl-2-Associated X Protein; Brain-Derived Neurotrophic Factor; Corti | 2022 |
Low-Dose IL-2 Attenuated Depression-like Behaviors and Pathological Changes through Restoring the Balances between IL-6 and TGF-β and between Th17 and Treg in a Chronic Stress-Induced Mouse Model of Depression.
Topics: Animals; Corticosterone; Depression; Disease Models, Animal; Interleukin-12; Interleukin-17; Interle | 2022 |
Low-Dose IL-2 Attenuated Depression-like Behaviors and Pathological Changes through Restoring the Balances between IL-6 and TGF-β and between Th17 and Treg in a Chronic Stress-Induced Mouse Model of Depression.
Topics: Animals; Corticosterone; Depression; Disease Models, Animal; Interleukin-12; Interleukin-17; Interle | 2022 |
Low-Dose IL-2 Attenuated Depression-like Behaviors and Pathological Changes through Restoring the Balances between IL-6 and TGF-β and between Th17 and Treg in a Chronic Stress-Induced Mouse Model of Depression.
Topics: Animals; Corticosterone; Depression; Disease Models, Animal; Interleukin-12; Interleukin-17; Interle | 2022 |
Low-Dose IL-2 Attenuated Depression-like Behaviors and Pathological Changes through Restoring the Balances between IL-6 and TGF-β and between Th17 and Treg in a Chronic Stress-Induced Mouse Model of Depression.
Topics: Animals; Corticosterone; Depression; Disease Models, Animal; Interleukin-12; Interleukin-17; Interle | 2022 |
Low-Dose IL-2 Attenuated Depression-like Behaviors and Pathological Changes through Restoring the Balances between IL-6 and TGF-β and between Th17 and Treg in a Chronic Stress-Induced Mouse Model of Depression.
Topics: Animals; Corticosterone; Depression; Disease Models, Animal; Interleukin-12; Interleukin-17; Interle | 2022 |
Low-Dose IL-2 Attenuated Depression-like Behaviors and Pathological Changes through Restoring the Balances between IL-6 and TGF-β and between Th17 and Treg in a Chronic Stress-Induced Mouse Model of Depression.
Topics: Animals; Corticosterone; Depression; Disease Models, Animal; Interleukin-12; Interleukin-17; Interle | 2022 |
Low-Dose IL-2 Attenuated Depression-like Behaviors and Pathological Changes through Restoring the Balances between IL-6 and TGF-β and between Th17 and Treg in a Chronic Stress-Induced Mouse Model of Depression.
Topics: Animals; Corticosterone; Depression; Disease Models, Animal; Interleukin-12; Interleukin-17; Interle | 2022 |
Low-Dose IL-2 Attenuated Depression-like Behaviors and Pathological Changes through Restoring the Balances between IL-6 and TGF-β and between Th17 and Treg in a Chronic Stress-Induced Mouse Model of Depression.
Topics: Animals; Corticosterone; Depression; Disease Models, Animal; Interleukin-12; Interleukin-17; Interle | 2022 |
Low-Dose IL-2 Attenuated Depression-like Behaviors and Pathological Changes through Restoring the Balances between IL-6 and TGF-β and between Th17 and Treg in a Chronic Stress-Induced Mouse Model of Depression.
Topics: Animals; Corticosterone; Depression; Disease Models, Animal; Interleukin-12; Interleukin-17; Interle | 2022 |
The Effects of Acute and Repeated Administration of Ketamine on Memory, Behavior, and Plasma Corticosterone Levels in Female Mice.
Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Depressive Disorder, Major; Female; | 2023 |
The Effects of Acute and Repeated Administration of Ketamine on Memory, Behavior, and Plasma Corticosterone Levels in Female Mice.
Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Depressive Disorder, Major; Female; | 2023 |
The Effects of Acute and Repeated Administration of Ketamine on Memory, Behavior, and Plasma Corticosterone Levels in Female Mice.
Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Depressive Disorder, Major; Female; | 2023 |
The Effects of Acute and Repeated Administration of Ketamine on Memory, Behavior, and Plasma Corticosterone Levels in Female Mice.
Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Depressive Disorder, Major; Female; | 2023 |
Antidepressant-Like Effects of Edaravone and Minocycline: Investigation of Oxidative Stress, Neuroinflammation, Neurotrophic, and Apoptotic Pathways.
Topics: Acetylcholinesterase; Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; | 2022 |
Antidepressant-Like Effects of Edaravone and Minocycline: Investigation of Oxidative Stress, Neuroinflammation, Neurotrophic, and Apoptotic Pathways.
Topics: Acetylcholinesterase; Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; | 2022 |
Antidepressant-Like Effects of Edaravone and Minocycline: Investigation of Oxidative Stress, Neuroinflammation, Neurotrophic, and Apoptotic Pathways.
Topics: Acetylcholinesterase; Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; | 2022 |
Antidepressant-Like Effects of Edaravone and Minocycline: Investigation of Oxidative Stress, Neuroinflammation, Neurotrophic, and Apoptotic Pathways.
Topics: Acetylcholinesterase; Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; | 2022 |
MAD2B Blunts Chronic Unpredictable Stress and Corticosterone Stimulation-Induced Depression-Like Behaviors in Mice.
Topics: Animals; Corticosterone; Depression; Disease Models, Animal; Hippocampus; Mice; MicroRNAs; Rats; Str | 2023 |
Antidepressive-Like Effect of
Topics: Aegle; Anhedonia; Animals; Antidepressive Agents; Corticosterone; Depression; Disease Models, Animal | 2022 |
Baicalin Ameliorates Corticosterone-Induced Depression by Promoting Neurodevelopment of Hippocampal via mTOR/GSK3β Pathway.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal | 2023 |
Antidepressant-like effect of endogenous SO
Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal | 2023 |
Dynamic Changes of Behavioral Despair, HPA Axis Activity, and Hippocampal Neurogenesis in Male Rats Induced by Social Defeat Stress.
Topics: Animals; Corticosterone; Depression; Hippocampus; Hypothalamo-Hypophyseal System; Male; Neurogenesis | 2023 |
SNS alleviates depression-like behaviors in CUMS mice by regluating dendritic spines via NCOA4-mediated ferritinophagy.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Dendritic Spines; Depression; Dise | 2023 |
Areca catechu L. ameliorates chronic unpredictable mild stress-induced depression behavior in rats by the promotion of the BDNF signaling pathway.
Topics: Animals; Antidepressive Agents; Areca; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticos | 2023 |
Topics: Animals; Anti-Inflammatory Agents; Anxiety; Brain-Derived Neurotrophic Factor; Corticosterone; Depre | 2023 |
Network analysis of comorbid depression, suicidality and biomarkers on HPA axis among mood disorder patients to psychiatric emergency services.
Topics: Adrenocorticotropic Hormone; Biomarkers; Corticosterone; Depression; Emergency Services, Psychiatric | 2023 |
Wistar-Kyoto rats and chronically stressed Wistar rats present similar depression- and anxiety-like behaviors but different corticosterone and endocannabinoid system modulation.
Topics: Animals; Anxiety; Corticosterone; Depression; Depressive Disorder, Major; Disease Models, Animal; En | 2023 |
Quercetin mitigates depression-like behavior via the suppression of neuroinflammation and oxidative damage in corticosterone-induced mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; | 2023 |
Dried Loquat Fruit Extract Containing Chlorogenic Acid Prevents Depressive-like Behaviors Induced by Repeated Corticosteroid Injections in Mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Chlorogenic Acid; Corticosterone; Depression; Dise | 2023 |
Reelin Rescues Behavioral, Electrophysiological, and Molecular Metrics of a Chronic Stress Phenotype in a Similar Manner to Ketamine.
Topics: Animals; Antidepressive Agents; Benchmarking; Corticosterone; Depression; Hippocampus; Ketamine; Mal | 2023 |
Emotional behaviors as well as the hippocampal reelin expression in C57BL/6N male mice chronically treated with corticosterone.
Topics: Animals; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Emotions; Glucocortic | 2023 |
Comparison of maternal versus postweaning ingestion of a high fat, high sucrose diet on depression-related behavior, novelty reactivity, and corticosterone levels in young, adult rat offspring.
Topics: Animals; Body Weight; Corticosterone; Depression; Diet, High-Fat; Eating; Female; Humans; Lactation; | 2023 |
Social avoidance and altered hypothalamic-pituitary-adrenal axis in a mouse model of anxious depression: The role of LPA
Topics: Animals; Corticosterone; Depression; Disease Models, Animal; Humans; Hypothalamo-Hypophyseal System; | 2023 |
Environmental stress during adolescence promotes depression-like behavior and endocrine abnormalities in rats.
Topics: Animals; Corticosterone; Depression; Female; Leptin; Male; Neuropeptide Y; Progesterone; Rats; Rats, | 2024 |
A comparative analysis of depressive-like behavior: Exploring sex-related differences and insights.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal | 2023 |
Acute stress imposed during adolescence yields heightened anxiety in Sprague Dawley rats that persists into adulthood: Sex differences and potential involvement of the Medial Amygdala.
Topics: Animals; Anxiety; Anxiety Disorders; Brain; Corticomedial Nuclear Complex; Corticosterone; Corticotr | 2019 |
Effects of cholecalciferol on behavior and production of reactive oxygen species in female mice subjected to corticosterone-induced model of depression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Cholecalciferol; Corticosterone; Depression; Disea | 2020 |
Effect of Chronic Corticosterone Treatment on Depression-Like Behavior and Sociability in Female and Male C57BL/6N Mice.
Topics: Animals; Corticosterone; Depression; Female; Male; Mice; Mice, Inbred C57BL; Sex Factors; Social Beh | 2019 |
Deficiency in Androgen Receptor Aggravates the Depressive-Like Behaviors in Chronic Mild Stress Model of Depression.
Topics: Androgen Antagonists; Animals; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Female | 2019 |
Dammarane sapogenins alleviates depression-like behaviours induced by chronic social defeat stress in mice through the promotion of the BDNF signalling pathway and neurogenesis in the hippocampus.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Corticosterone; Dammaranes; Depre | 2019 |
Systematic analysis of severity in a widely used cognitive depression model for mice.
Topics: Animal Welfare; Animals; Body Weight; Corticosterone; Depression; Disease Models, Animal; Helplessne | 2020 |
Neonatal Immune Activation May Provoke Long-term Depressive Attributes.
Topics: Animals; Animals, Newborn; Corticosterone; Depression; Depressive Disorder; Disease Models, Animal; | 2019 |
Thymol reverses depression-like behaviour and upregulates hippocampal BDNF levels in chronic corticosterone-induced depression model in female mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; | 2019 |
Antidepressant activity of crocin-I is associated with amelioration of neuroinflammation and attenuates oxidative damage induced by corticosterone in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Carotenoids; Corticosterone; Depression; Hippocamp | 2019 |
Metabolomic evidence for the therapeutic effect of gentiopicroside in a corticosterone-induced model of depression.
Topics: Animals; Apoptosis; Arachidonic Acid; Cell Line, Tumor; Corticosterone; Depression; Disease Models, | 2019 |
Gamma-aminobutyric acid-producing lactobacilli positively affect metabolism and depressive-like behaviour in a mouse model of metabolic syndrome.
Topics: Adipose Tissue; Animals; Behavior, Animal; Body Weight; Cholesterol; Corticosterone; Depression; Dis | 2019 |
Fluoxetine attenuates stress-induced depressive-like behavior through modulation of hippocampal GAP43 and neurogenesis in male rats.
Topics: Animals; Behavior, Animal; Corticosterone; Depression; Fluoxetine; GAP-43 Protein; Hippocampus; Inte | 2020 |
Link between personality and response to THC exposure.
Topics: Animals; Behavior, Animal; Cannabinoid Receptor Agonists; Conditioning, Psychological; Corticosteron | 2020 |
Atopic dermatitis induces anxiety- and depressive-like behaviors with concomitant neuronal adaptations in brain reward circuits in mice.
Topics: Adaptation, Psychological; Animals; Anxiety; Behavior, Animal; Brain Chemistry; Brain-Derived Neurot | 2020 |
Royal jelly reduces depression-like behavior through possible effects on adrenal steroidogenesis in a murine model of unpredictable chronic mild stress.
Topics: Adrenal Glands; Animals; Body Weight; Chronic Disease; Corticosterone; Depression; Disease Models, A | 2020 |
Selective activation of estrogen receptors α and β: Implications for depressive-like phenotypes in female mice exposed to chronic unpredictable stress.
Topics: Animals; Chronic Disease; Corticosterone; Depression; Estradiol; Estrogen Receptor alpha; Estrogen R | 2020 |
β-Catenin Role in the Vulnerability/Resilience to Stress-Related Disorders Is Associated to Changes in the Serotonergic System.
Topics: Animals; Anxiety; Behavior, Animal; beta Catenin; Corticosterone; Depression; Hippocampus; Male; Mic | 2020 |
Selective effects of dorsal raphé nucleus glucocorticoid receptor deletion on depression-like behavior in female C57BL/6J mice.
Topics: Animals; Behavior, Animal; Corticosterone; Depression; Depressive Disorder; Dorsal Raphe Nucleus; Fe | 2020 |
Effects of Puerarin on the Ovariectomy-Induced Depressive-Like Behavior in ICR Mice and Its Possible Mechanism of Action.
Topics: Animals; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Disease Models, Animal; Doub | 2019 |
Differential effects of stress exposure via two types of restraint apparatuses on behavior and plasma corticosterone level in inbred male BALB/cAJcl mice.
Topics: Animals; Anxiety; Behavior, Animal; Body Weight; Corticosterone; Depression; Disease Models, Animal; | 2020 |
Proteomic profiling of the neurons in mice with depressive-like behavior induced by corticosterone and the regulation of berberine: pivotal sites of oxidative phosphorylation.
Topics: Animals; Behavior, Animal; Berberine; Cell Survival; Corticosterone; Depression; Disease Models, Ani | 2019 |
Fructo-oligosaccharides from Morinda officinalis remodeled gut microbiota and alleviated depression features in a stress rat model.
Topics: Animals; Antidepressive Agents; Corticosterone; Depression; Feces; Gastrointestinal Microbiome; Inte | 2020 |
Duloxetine reverses the symptoms of overactive bladder co-existing with depression via the central pathways.
Topics: Acetanilides; Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Disease | 2020 |
A novel stress re-stress model: modification of re-stressor cue induces long-lasting post-traumatic stress disorder-like symptoms in rats.
Topics: Animals; Anxiety; Behavior, Animal; Cognitive Dysfunction; Corticosterone; Cues; Depression; Disease | 2020 |
The Role of Annexin A1 and Formyl Peptide Receptor 2/3 Signaling in Chronic Corticosterone-Induced Depression-Like behaviors and Impairment in Hippocampal-Dependent Memory.
Topics: Animals; Annexin A1; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Glucocorticoids; | 2020 |
Exploring the ameliorative role of α7 neuronal nicotinic acetylcholine receptor modulation in epilepsy and associated comorbidities in post-PTZ-kindled mice.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anticonvulsants; Corticosterone; Depression; Dose- | 2020 |
I. inflexus (Thunb.) Kudo extract improves atopic dermatitis and depressive-like behavior in DfE-induced atopic dermatitis-like disease.
Topics: Animals; Behavior, Animal; Cell Line; Corticosterone; Cytokines; Depression; Dermatitis, Atopic; Der | 2020 |
Fast-acting antidepressant-like effects of Reelin evaluated in the repeated-corticosterone chronic stress paradigm.
Topics: Animals; Antidepressive Agents; Corticosterone; Depression; Doublecortin Protein; Hippocampus; Neuro | 2020 |
Chronic unpredictable restraint stress increases hippocampal pro-inflammatory cytokines and decreases motivated behavior in rats.
Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Cytokines; Depression; Disease Models, Animal; H | 2020 |
Effect of probiotic administration on gut microbiota and depressive behaviors in mice.
Topics: Animals; Behavior, Animal; Corticosterone; Depression; Gastrointestinal Microbiome; Locomotion; Male | 2020 |
Contribution of glia cells specifically astrocytes in the pathology of depression: immunohistochemical study in different brain areas.
Topics: Animals; Astrocytes; Brain; Cell Count; Corticosterone; Depression; Glial Fibrillary Acidic Protein; | 2020 |
Morus nigra leaves extract revokes the depressive-like behavior, oxidative stress, and hippocampal damage induced by corticosterone: a pivotal role of the phenolic syringic acid.
Topics: Animals; Antioxidants; Behavior, Animal; Cell Survival; Corticosterone; Depression; Fluoxetine; Gall | 2020 |
Glucocorticoid and brain-derived neurotrophic factor relationship: a brief investigation into the model of depression by chronic administration of corticosterone.
Topics: Adrenal Glands; Animals; Body Weight; Brain-Derived Neurotrophic Factor; Corpus Striatum; Corticoste | 2020 |
Depression-like behaviors are accompanied by disrupted mitochondrial energy metabolism in chronic corticosterone-induced mice.
Topics: Adenosine Triphosphate; Animals; Corticosterone; Depression; Energy Metabolism; Lipid Metabolism; Li | 2020 |
Valproic acid administration exerts protective effects against stress-related anhedonia in rats.
Topics: Anhedonia; Animals; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Histone De | 2020 |
(S)-norketamine and (2S,6S)-hydroxynorketamine exert potent antidepressant-like effects in a chronic corticosterone-induced mouse model of depression.
Topics: Anhedonia; Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Disease Mod | 2020 |
Oleuropein Reverses Repeated Corticosterone-Induced Depressive-Like Behavior in mice: Evidence of Modulating Effect on Biogenic Amines.
Topics: Anhedonia; Animals; Behavior, Animal; Biogenic Amines; Brain; Corticosterone; Depression; Disease Mo | 2020 |
Prefrontal cortex infusion of beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, produces antidepressant-like effects in a rodent model of depression.
Topics: 3-Hydroxybutyric Acid; Animals; Antidepressive Agents; Corticosterone; Depression; Disease Models, A | 2020 |
Sex differences in hypothalamic-pituitary-adrenal axis regulation after chronic unpredictable stress.
Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Female; Hypothalamo-Hypophyseal Syst | 2020 |
Hypothalamus-pituitary-adrenal axis imbalance and inflammation contribute to sex differences in separation- and restraint-induced depression.
Topics: Animals; Anxiety, Separation; Corticosterone; Depression; Female; Hypothalamo-Hypophyseal System; In | 2020 |
Infliximab prevents dysfunction of the vas deferens by suppressing inflammation and oxidative stress in rats with chronic stress.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Corticosterone; Depression; Dose-Respon | 2020 |
Antidepressants of different classes cause distinct behavioral and brain pro- and anti-inflammatory changes in mice submitted to an inflammatory model of depression.
Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents; Brain; Citalopram; Corticosterone; Cytokin | 2020 |
Prenatal maternal stress alters depression-related symptoms in a strain - and sex-dependent manner in rodent offspring.
Topics: Animals; Brain; Corticosterone; Depression; Female; Male; Mice; Mice, Inbred C57BL; Pregnancy; Pregn | 2020 |
The neuroprotective effect of Riparin IV on oxidative stress and neuroinflammation related to chronic stress-induced cognitive impairment.
Topics: Animals; Antioxidants; Behavior, Animal; Brain; Chronic Disease; Cognitive Dysfunction; Corticostero | 2020 |
Apocynin as an antidepressant agent: in vivo behavior and oxidative parameters modulation.
Topics: Acetophenones; Animals; Antidepressive Agents; Antioxidants; Brain; Corticosterone; Depression; Male | 2020 |
Sepsis survivor mice exhibit a behavioral endocrine syndrome with ventral hippocampal dysfunction.
Topics: Acute Disease; Animals; Anxiety; Behavior, Animal; Corticosterone; Critical Illness; Depression; Dis | 2020 |
The influence of the duration of chronic unpredictable mild stress on the behavioural responses of C57BL/6J mice.
Topics: Animals; Behavior, Animal; Body Weight; Corticosterone; Depression; Disease Models, Animal; Hindlimb | 2020 |
Role of glucocorticoid receptor phosphorylation-mediated synaptic plasticity in anxiogenic and depressive behaviors induced by monosodium glutamate.
Topics: Animals; Anxiety; Behavior, Animal; Brain; Brain-Derived Neurotrophic Factor; Corticosterone; Dendri | 2021 |
Effects of Chronic Cannabidiol Treatment in the Rat Chronic Unpredictable Mild Stress Model of Depression.
Topics: Animals; Body Weight; Cannabidiol; Corticosterone; Depression; Exploratory Behavior; Injections, Int | 2020 |
Ginsenoside 20(S)-protopanaxadiol attenuates depressive-like behaviour and neuroinflammation in chronic unpredictable mild stress-induced depressive rats.
Topics: Animals; Apoptosis; Corticosterone; Cytokines; Depression; Disease Models, Animal; Encephalitis; Gin | 2020 |
Guanosine potentiates the antidepressant-like effect of subthreshold doses of ketamine: Possible role of pro-synaptogenic signaling pathway.
Topics: Animals; Antidepressive Agents; Corticosterone; Depression; Guanosine; Humans; Ketamine; Mice; Prefr | 2020 |
Probiotic treatment (Bifidobacterium longum subsp. longum 35624™) affects stress responsivity in male rats after chronic corticosterone exposure.
Topics: Animals; Behavior, Animal; Bifidobacterium; Brain; Corticosterone; Depression; Doublecortin Domain P | 2020 |
Endurance training exerts time-dependent modulation on depressive responses and circadian rhythms of corticosterone and BDNF in the rats with pinealectomy.
Topics: Animals; Brain-Derived Neurotrophic Factor; Circadian Rhythm; Corticosterone; Depression; Endurance | 2020 |
Brain stimulation rewarding experience attenuates neonatal clomipramine-induced adulthood anxiety by reversal of pathological changes in the amygdala.
Topics: Amygdala; Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Anxiety; Biogenic Monoamines; | 2020 |
Pitolisant protects mice chronically treated with corticosterone from some behavioral but not metabolic changes in corticosterone-induced depression model.
Topics: Animals; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Histamine H3 Antagoni | 2020 |
Mechanisms underlying remediation of depression-associated anxiety by chronic N-acetyl cysteine treatment.
Topics: Acetylcysteine; Amygdala; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Corticostero | 2020 |
Cholecalciferol abolishes depressive-like behavior and hippocampal glucocorticoid receptor impairment induced by chronic corticosterone administration in mice.
Topics: Animals; Antidepressive Agents, Second-Generation; Beclin-1; Behavior, Animal; Cholecalciferol; Cort | 2020 |
Ketamine contributes to the alteration of Ca
Topics: Analgesics; Animals; Antidepressive Agents; Calcium Signaling; Corticosterone; Depression; Female; K | 2020 |
New insights into the effects of caffeine on adult hippocampal neurogenesis in stressed mice: Inhibition of CORT-induced microglia activation.
Topics: Animals; Antidepressive Agents; Caffeine; Corticosterone; Depression; Disease Models, Animal; Hippoc | 2020 |
Chronic Corticosterone Elevation Suppresses Adult Hippocampal Neurogenesis by Hyperphosphorylating Huntingtin.
Topics: Aging; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; Cyclin-Dependen | 2020 |
Subthreshold doses of guanosine plus ketamine elicit antidepressant-like effect in a mouse model of depression induced by corticosterone: Role of GR/NF-κB/IDO-1 signaling.
Topics: Animals; Antidepressive Agents; Corticosterone; Depression; Disease Models, Animal; Drug Therapy, Co | 2020 |
Cyclical administration of corticosterone results in aggravation of depression-like behaviors and accompanying downregulations in reelin in an animal model of chronic stress relevant to human recurrent depression.
Topics: Animals; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Down-Regulation; Extr | 2020 |
Chronic stress followed by social isolation promotes depressive-like behaviour, alters microglial and astrocyte biology and reduces hippocampal neurogenesis in male mice.
Topics: Animals; Astrocytes; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Hippocamp | 2021 |
Antidepressant-like effects of Lactobacillus plantarum DP189 in a corticosterone-induced rat model of chronic stress.
Topics: Animals; Antidepressive Agents; Apoptosis; Behavior, Animal; Brain; Chronic Disease; Corticosterone; | 2020 |
Long-term exercise from adolescence to adulthood reduces anxiety- and depression-like behaviors following maternal immune activation in offspring.
Topics: Adjuvants, Immunologic; Animals; Anxiety; Anxiety Disorders; Behavior, Animal; Corticosterone; Depre | 2020 |
Ketamine, but not guanosine, as a prophylactic agent against corticosterone-induced depressive-like behavior: Possible role of long-lasting pro-synaptogenic signaling pathway.
Topics: Animals; Antidepressive Agents; Corticosterone; Depression; Guanosine; Hindlimb Suspension; Hippocam | 2020 |
Phosphodiesterase 2 inhibitor Hcyb1 reverses corticosterone-induced neurotoxicity and depression-like behavior.
Topics: Animals; Antidepressive Agents; Corticosterone; Cyclic Nucleotide Phosphodiesterases, Type 2; Depres | 2020 |
The Effect of Swimming on Anxiety-Like Behaviors and Corticosterone in Stressed and Unstressed Rats.
Topics: Animals; Anxiety; Corticosterone; Depression; Male; Rats; Rats, Wistar; Stress, Psychological; Swimm | 2020 |
Antistress and antidepressant properties of dapoxetine and vortioxetine.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Benzylamines; Corticosterone; Depression; Male; Na | 2020 |
Curcumin Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-Like Behaviors via Restoring Changes in Oxidative Stress and the Activation of Nrf2 Signaling Pathway in Rats.
Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; Curcumin; Depression; | 2020 |
Bag-1 mediates glucocorticoid receptor trafficking to mitochondria after corticosterone stimulation: Potential role in regulating affective resilience.
Topics: Affect; Anhedonia; Animals; Corticosterone; Depression; DNA-Binding Proteins; Dose-Response Relation | 2021 |
Low corticosterone levels attenuate late life depression and enhance glutamatergic neurotransmission in female rats.
Topics: Animals; Astrocytes; Corticosterone; Depression; Excitatory Amino Acid Transporter 2; Female; Glutam | 2021 |
Indirect exposure to socially defeated conspecifics using recorded video activates the HPA axis and reduces reward sensitivity in mice.
Topics: Anhedonia; Animals; Brain; Choice Behavior; Corticosterone; Depression; Disease Models, Animal; Empa | 2020 |
Sex-specific Effects of Lipopolysaccharide on Hippocampal Mitochondrial Processes in Neuroinflammatory Model of Depression.
Topics: Animals; Corticosterone; Depression; Female; Hippocampus; Hypothalamo-Hypophyseal System; Lipopolysa | 2020 |
Maternal Separation Model of Postpartum Depression: Potential Role for Nucleus Accumbens Dopamine D1-D2 Receptor Heteromer.
Topics: Animals; Anxiety; Corticosterone; Depression; Depression, Postpartum; Female; Male; Maternal Behavio | 2020 |
Antidepressant-like mechanism of honokiol in a rodent model of corticosterone-induced depression.
Topics: Animals; Antidepressive Agents; Biphenyl Compounds; Corticosterone; Depression; Disease Models, Anim | 2020 |
Dicaffeoylquinic acids alleviate memory loss via reduction of oxidative stress in stress-hormone-induced depressive mice.
Topics: Animals; Antidepressive Agents; Antioxidants; Astrocytes; Behavior, Animal; Cells, Cultured; Cortico | 2020 |
Effects of body weight-supported treadmill training at different speeds on the motor function and depressive behaviors after spinal cord injury in rats.
Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Exercise T | 2020 |
The influence of rat strain on the development of neuropathic pain and comorbid anxio-depressive behaviour after nerve injury.
Topics: Animals; Anxiety; Behavior, Animal; Comorbidity; Corticosterone; Depression; Feces; Gait; Hyperalges | 2020 |
2-Phenylethylamine (PEA) Ameliorates Corticosterone-Induced Depression-Like Phenotype via the BDNF/TrkB/CREB Signaling Pathway.
Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; Cyclic AMP Response El | 2020 |
Adult neurogenesis augmentation attenuates anhedonia and HPA axis dysregulation in a mouse model of chronic stress and depression.
Topics: Anhedonia; Animals; Behavior, Animal; Corticosterone; Depression; Depressive Disorder, Major; Diseas | 2021 |
Uncaria rhynchophylla ameliorates unpredictable chronic mild stress-induced depression in mice via activating 5-HT
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Computational Biology; Corticosterone; | 2021 |
Naringenin improves depressive- and anxiety-like behaviors in mice exposed to repeated hypoxic stress through modulation of oxido-inflammatory mediators and NF-kB/BDNF expressions.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Brain; Brain-Derived Neurotrophic Fact | 2021 |
Ursolic acid abrogates depressive-like behavior and hippocampal pro-apoptotic imbalance induced by chronic unpredictable stress.
Topics: Animals; Antidepressive Agents; Apoptosis; Behavior, Animal; Corticosterone; Depression; Fluoxetine; | 2021 |
Protective Effects of Milk Casein on the Brain Function and Behavior in a Mouse Model of Chronic Stress.
Topics: Animals; Behavior, Animal; Brain; Caseins; Corticosterone; Depression; Disease Models, Animal; Mice; | 2021 |
Knockout of the circadian gene, Per2, disrupts corticosterone secretion and results in depressive-like behaviors and deficits in startle responses.
Topics: Animals; Circadian Rhythm; Corticosterone; Depression; Hypothalamo-Hypophyseal System; Male; Mice; M | 2021 |
Indoxyl sulfate caused behavioral abnormality and neurodegeneration in mice with unilateral nephrectomy.
Topics: Affect; Animals; Anxiety; Behavior, Animal; Brain-Derived Neurotrophic Factor; Carbon; Cell Survival | 2021 |
Metformin Attenuates the Metabolic Disturbance and Depression-like Behaviors Induced by Corticosterone and Mediates the Glucose Metabolism Pathway.
Topics: Animals; Chromatography, Liquid; Corticosterone; Depression; Glucose; Humans; Metformin; Rats; Tande | 2021 |
Early Enriched Environment Prevents Epigenetic p11 Gene Changes Induced by Adulthood Stress in Mice.
Topics: Acetylation; Animals; Annexin A2; Corticosterone; Depression; Epigenesis, Genetic; Gene Expression; | 2021 |
Venlafaxine reduces the striatal il6/il10 ratio and increases hippocampal GR expression in female mice subjected to chronic social instability stress.
Topics: Animals; Corticosterone; Depression; Female; Hippocampus; Interleukin-10; Interleukin-6; Mice; Stres | 2021 |
Sleep disturbance induces depressive behaviors and neuroinflammation by altering the circadian oscillations of clock genes in rats.
Topics: Animals; Corticosterone; Depression; Hypothalamo-Hypophyseal System; Pituitary-Adrenal System; Rats; | 2021 |
Is Riparin III a promising drug in the treatment for depression?
Topics: Animals; Behavior, Animal; Benzamides; Corticosterone; Depression; Disease Models, Animal; Female; M | 2021 |
Altered acoustic startle, prepulse facilitation, and object recognition memory produced by corticosterone withdrawal in male rats.
Topics: Animals; Anti-Inflammatory Agents; Behavior, Animal; Cognitive Dysfunction; Corticosterone; Depressi | 2021 |
Exercise and fluoxetine treatment during adolescence protect against early life stress-induced behavioral abnormalities in adult rats.
Topics: Animals; Animals, Newborn; Antidepressive Agents, Second-Generation; Anxiety; Behavior, Animal; Cort | 2021 |
A single administration of ascorbic acid rapidly reverses depressive-like behavior and hippocampal synaptic dysfunction induced by corticosterone in mice.
Topics: Animals; Antidepressive Agents; Ascorbic Acid; Corticosterone; Dendritic Spines; Depression; Female; | 2021 |
Neuroprotective and Antioxidant Effects of Riparin I in a Model of Depression Induced by Corticosterone in Female Mice.
Topics: Animals; Antioxidants; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; Depressi | 2022 |
Synergy of oxytocin and citalopram in modulating Itgb3/Chl1 interplay: Relevance to sensitivity to SSRI therapy.
Topics: Animals; Antidepressive Agents; Anxiety; Cell Adhesion Molecules; Citalopram; Corticosterone; Depres | 2021 |
Ketamine, but not fluoxetine, rapidly rescues corticosterone-induced impairments on glucocorticoid receptor and dendritic branching in the hippocampus of mice.
Topics: Animals; Corticosterone; Depression; Fluoxetine; Hippocampus; Ketamine; Mice; Receptors, Glucocortic | 2021 |
5-HT
Topics: Animals; Anxiety; Corticosterone; Depression; Fluoxetine; Hippocampus; Mice; Serotonin | 2021 |
Antidepressant-like effects of acupuncture via modulation of corticosterone, sex hormones, and hippocampal BDNF expression in male rats.
Topics: Acupuncture Therapy; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; D | 2021 |
Effects of enriched environment on depression and anxiety-like behavior induced by early life stress: A comparison between different periods.
Topics: Age Factors; Animals; Anxiety; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Enviro | 2021 |
A low-dose combination of ketamine and guanosine counteracts corticosterone-induced depressive-like behavior and hippocampal synaptic impairments via mTORC1 signaling.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Corticosterone; Depression; Dose-Re | 2021 |
Quantitation of six steroid hormones by ultra-performance liquid chromatography-tandem mass spectrometry in plasma and prefrontal cortex samples from rats with chronic unpredictable mild stress-induced depression.
Topics: Animals; Chromatography, High Pressure Liquid; Corticosterone; Depression; Disease Models, Animal; L | 2021 |
Dietary EPA-Enriched Phospholipids Alleviate Chronic Stress and LPS-Induced Depression- and Anxiety-Like Behavior by Regulating Immunity and Neuroinflammation.
Topics: Animals; Anxiety; Behavior, Animal; Brain; Corticosterone; Depression; Disease Models, Animal; Eicos | 2021 |
Komagataella pastoris KM71H modulates neuroimmune and oxidative stress parameters in animal models of depression: A proposal for a new probiotic with antidepressant-like effect.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Blood-Brain Barrier; Brain; Corticosterone; Depres | 2021 |
Legumain knockout improves repeated corticosterone injection-induced depression-like emotional and cognitive deficits.
Topics: Animals; Behavior, Animal; Cognitive Dysfunction; Corticosterone; Cysteine Endopeptidases; Depressio | 2021 |
Low doses of ketamine and guanosine abrogate corticosterone-induced anxiety-related behavior, but not disturbances in the hippocampal NLRP3 inflammasome pathway.
Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Guanosine; Hippocampus; Inflammasome | 2021 |
Behavioral alterations, brain oxidative stress, and elevated levels of corticosterone associated with a pressure injury model in male mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain; Corticosterone; Depression; Disease Models, | 2022 |
Therapeutic Potential of Curcumin in Reversing the Depression and Associated Pseudodementia via Modulating Stress Hormone, Hippocampal Neurotransmitters, and BDNF Levels in Rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain-Derived Neurotrophic Factor; Corticosterone; | 2021 |
Synergistic effects of combined therapy with transcranial photobiomodulation and enriched environment on depressive- and anxiety-like behaviors in a mice model of noise stress.
Topics: Animals; Anxiety; Behavior, Animal; Brain-Derived Neurotrophic Factor; Combined Modality Therapy; Co | 2022 |
Highly palatable food access during adolescence increased anxiety-/depression-like behaviors in male, but not in female, rats.
Topics: Animals; Anxiety; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; D | 2018 |
Mangiferin prevents corticosterone-induced behavioural deficits via alleviation of oxido-nitrosative stress and down-regulation of indoleamine 2,3-dioxygenase (IDO) activity.
Topics: Animals; Anti-Inflammatory Agents; Anxiety; Behavior, Animal; Corticosterone; Depression; Down-Regul | 2017 |
Ovarian hormones modify anxiety behavior and glucocorticoid receptors after chronic social isolation stress.
Topics: Animals; Anxiety; Chronic Disease; Corticosterone; Depression; Estrous Cycle; Female; Hippocampus; H | 2017 |
Curcumin reverses the depressive-like behavior and insulin resistance induced by chronic mild stress.
Topics: Animals; Behavior, Animal; Blood Glucose; Corticosterone; Curcumin; Depression; Disease Models, Anim | 2017 |
Depressive behavior induced by unpredictable chronic mild stress increases dentin hypersensitivity in rats.
Topics: Animals; Corticosterone; Dentin Sensitivity; Depression; Disease Models, Animal; Glial Fibrillary Ac | 2017 |
Molecular Adaptations to Social Defeat Stress and Induced Depression in Mice.
Topics: Animals; Binding Sites; Chronic Disease; Corticosterone; Depression; Gene Expression Profiling; Gene | 2018 |
Hyperoside protects against chronic mild stress-induced learning and memory deficits.
Topics: Animals; Brain-Derived Neurotrophic Factor; Carbazoles; Chronic Disease; Cognition; Corticosterone; | 2017 |
Intergenerational accumulation of impairments in maternal behavior following postnatal social stress.
Topics: Aggression; Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Female; Hypothalamo-Hypo | 2017 |
Elevated paternal glucocorticoid exposure modifies memory retention in female offspring.
Topics: Animals; Anxiety; Anxiety Disorders; Cognition; Corticosterone; Depression; Epigenesis, Genetic; Fat | 2017 |
JIEYUANSHEN DECOCTION EXERTS ANTIDEPRESSANT EFFECTS ON DEPRESSIVE RAT MODEL VIA REGULATING HPA AXIS AND THE LEVEL OF AMINO ACIDS NEUROTRANSMITTER.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Chronic Disease; Corticosterone; Cortic | 2017 |
Antidepressive effects of ginsenoside Rg1 via regulation of HPA and HPG axis.
Topics: Affect; Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Disease Models | 2017 |
Methyl jasmonate attenuated lipopolysaccharide-induced depressive-like behaviour in mice.
Topics: Acetates; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; Brain; | 2017 |
Preventive Effects of Ginseng Total Saponins on Chronic Corticosterone-Induced Impairment in Astrocyte Structural Plasticity and Hippocampal Atrophy.
Topics: Animals; Antidepressive Agents; Astrocytes; Atrophy; Corticosterone; Depression; Disease Models, Ani | 2017 |
Exposure to chronic variable social stress during adolescence alters affect-related behaviors and adrenocortical activity in adult male and female inbred mice.
Topics: Affect; Animals; Behavior, Animal; Corticosterone; Depression; Exploratory Behavior; Female; Male; M | 2017 |
Ferulic acid reverses depression-like behavior and oxidative stress induced by chronic corticosterone treatment in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Biomarkers; Corticosterone; Coumaric Acids; Depres | 2017 |
Profiling coping strategies in male and female rats: Potential neurobehavioral markers of increased resilience to depressive symptoms.
Topics: Adaptation, Psychological; Animals; Behavior, Animal; Biomarkers; Brain; Corticosterone; Dehydroepia | 2017 |
Insights into the potential antidepressant mechanisms of cilostazol in chronically restraint rats: impact on the Nrf2 pathway.
Topics: Animals; Antidepressive Agents; Antioxidants; Cilostazol; Corticosterone; Depression; Depressive Dis | 2018 |
Reduced hippocampal IL-10 expression, altered monoaminergic activity and anxiety and depressive-like behavior in female mice subjected to chronic social instability stress.
Topics: Animals; Anxiety; Anxiety Disorders; Behavior, Animal; Biogenic Monoamines; Corticosterone; Cytokine | 2017 |
Fluoxetine coupled with zinc in a chronic mild stress model of depression: Providing a reservoir for optimum zinc signaling and neuronal remodeling.
Topics: Animals; Antidepressive Agents, Second-Generation; Brain; Chronic Disease; Corticosterone; Depressio | 2017 |
Can Ocimum basilicum relieve chronic unpredictable mild stress-induced depression in mice?
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; | 2017 |
Metformin and ascorbic acid combination therapy ameliorates type 2 diabetes mellitus and comorbid depression in rats.
Topics: Animals; Ascorbic Acid; Biogenic Monoamines; Blood Glucose; Comorbidity; Corticosterone; Cytokines; | 2017 |
Distinct modifications of hippocampal glucocorticoid receptor phosphorylation and FKBPs by lipopolysaccharide in depressive female and male rats.
Topics: Animals; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Depressive Disorder; Female; | 2017 |
Stellate ganglion block attenuates chronic stress induced depression in rats.
Topics: Adrenocorticotropic Hormone; Anesthetics, Local; Animals; Autonomic Nerve Block; bcl-2-Associated X | 2017 |
Differential effects of imipramine and CORT118335 (Glucocorticoid receptor modulator/mineralocorticoid receptor antagonist) on brain-endocrine stress responses and depression-like behavior in female rats.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behav | 2018 |
Saikosaponin D relieves unpredictable chronic mild stress induced depressive-like behavior in rats: involvement of HPA axis and hippocampal neurogenesis.
Topics: Animals; Antidepressive Agents; Arousal; Corticosterone; Depression; Doublecortin Protein; Hippocamp | 2017 |
Injection of oxytocin into paraventricular nucleus reverses depressive-like behaviors in the postpartum depression rat model.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Depression, Postpartum | 2018 |
Bifidobacterium pseudocatenulatum CECT 7765 Ameliorates Neuroendocrine Alterations Associated with an Exaggerated Stress Response and Anhedonia in Obese Mice.
Topics: Adiposity; Anhedonia; Animals; Anxiety; Behavior, Animal; Bifidobacterium; Catecholamines; Corticost | 2018 |
The BDNF Val66Met polymorphism regulates glucocorticoid-induced corticohippocampal remodeling and behavioral despair.
Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Disease Mo | 2017 |
Molecular changes associated with escitalopram response in a stress-based model of depression.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Citalopram; Corticosterone; Corticotrop | 2018 |
Sex differences in behavioral and neurochemical effects of gonadectomy and aromatase inhibition in rats.
Topics: Animals; Antidepressive Agents; Aromatase; Aromatase Inhibitors; Behavior, Animal; Brain; Castration | 2018 |
Agomelatine, venlafaxine, and running exercise effectively prevent anxiety- and depression-like behaviors and memory impairment in restraint stressed rats.
Topics: Acetamides; Animals; Antidepressive Agents, Second-Generation; Body Weight; Corticosterone; Depressi | 2017 |
Role of Cyclooxygenase Inhibitors in Diminution of Dissimilar Stress-induced Depressive Behavior and Memory Impairment in Rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biogenic Monoamines; Brain; Corticosterone; Cycloo | 2018 |
Paroxetine blunts the corticosterone response to swim-induced stress and increases depressive-like behavior in a rat model of postpartum depression.
Topics: Animals; Corticosterone; Depression; Depression, Postpartum; Disease Models, Animal; Female; Male; P | 2018 |
Regulation of actions and habits by ventral hippocampal trkB and adolescent corticosteroid exposure.
Topics: Adrenal Cortex Hormones; Animals; Behavior, Animal; Conditioning, Operant; Corticosterone; Depressio | 2017 |
Seizure-induced activation of the HPA axis increases seizure frequency and comorbid depression-like behaviors.
Topics: Animals; Corticosterone; Corticotropin-Releasing Hormone; Depression; Depressive Disorder; Hypothala | 2018 |
Combined corticosterone treatment and chronic restraint stress lead to depression associated with early cognitive deficits in mice.
Topics: Animals; Behavior, Animal; Cognition Disorders; Cognitive Dysfunction; Corticosterone; Depression; D | 2018 |
Therapeutic potential of silymarin in chronic unpredictable mild stress induced depressive-like behavior in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Cerebral Cortex; Corticosterone; Depression; Disea | 2018 |
Inability to suppress the stress-induced activation of the HPA axis during the peripartum period engenders deficits in postpartum behaviors in mice.
Topics: Animals; Behavior, Animal; Corticosterone; Corticotropin-Releasing Hormone; Depression; Depression, | 2018 |
Antidepressant-like effects of water extract of Gastrodia elata Blume on neurotrophic regulation in a chronic social defeat stress model.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Body Weight; Corticosterone; Depression; Gastrodia | 2018 |
ATP-sensitive potassium-channel inhibitor glibenclamide attenuates HPA axis hyperactivity, depression- and anxiety-related symptoms in a rat model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anxiety; Corticosterone; Depression; Disease Mode | 2018 |
Ocimum basilicum improve chronic stress-induced neurodegenerative changes in mice hippocampus.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; | 2018 |
Blue light filtered white light induces depression-like responses and temporary spatial learning deficits in rats.
Topics: Animals; Color; Corticosterone; Depression; Light; Male; Rats; Rats, Sprague-Dawley; Spatial Learnin | 2018 |
sst
Topics: Aging; Animals; Anxiety; Chronic Disease; Cognition; Cognitive Dysfunction; Corticosterone; Depressi | 2018 |
Preconception paternal bisphenol A exposure induces sex-specific anxiety and depression behaviors in adult rats.
Topics: Animals; Anxiety; Behavior, Animal; Benzhydryl Compounds; Corticosterone; Depression; Female; Male; | 2018 |
Antidepressant-Like Effects of Vaccinium bracteatum in Chronic Restraint Stress Mice: Functional Actions and Mechanism Explorations.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Biogenic Monoamines; Brain; Cells, Cultured; Chron | 2018 |
Long-term metabolic cage housing increases anxiety/depression-related behaviours in adult male rats.
Topics: Animal Husbandry; Animals; Anxiety; Behavior, Animal; Blood Glucose; Corticosterone; Depression; Mal | 2019 |
miR-124 antagonizes the antidepressant-like effects of standardized gypenosides in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; | 2018 |
Repeated Neck Restraint Stress Bidirectionally Modulates Excitatory Transmission in the Dentate Gyrus and Performance in a Hippocampus-dependent Memory Task.
Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Corticosterone; Dentate Gyrus; Depression; Excitatory | 2018 |
Antidepressant effects of magnolol in a mouse model of depression induced by chronic corticosterone injection.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Biphenyl Compounds; Brain-Derived Neurotrophic Fac | 2018 |
Perinatal exposure to venlafaxine leads to lower anxiety and depression-like behavior in the adult rat offspring.
Topics: Adrenal Cortex Hormones; Aldosterone; Animals; Animals, Newborn; Anxiety; Anxiety Disorders; Behavio | 2018 |
Total Saikosaponins of Bupleurum yinchowense reduces depressive, anxiety-like behavior and increases synaptic proteins expression in chronic corticosterine-treated mice.
Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Bupleurum; Corticosterone; Depression; Ma | 2018 |
Magnolol abrogates chronic mild stress-induced depressive-like behaviors by inhibiting neuroinflammation and oxidative stress in the prefrontal cortex of mice.
Topics: Adrenocorticotropic Hormone; Animals; Anti-Inflammatory Agents; Antidepressive Agents; Behavior, Ani | 2018 |
Elevated stress hormone levels and antidepressant treatment starting before pregnancy affect maternal care and litter characteristics in an animal model of depression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Depression, Postpartum | 2018 |
Flotillin-1 interacts with the serotonin transporter and modulates chronic corticosterone response.
Topics: Animals; Corticosterone; Depression; Female; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Prot | 2019 |
Baicalin Modulates APPL2/Glucocorticoid Receptor Signaling Cascade, Promotes Neurogenesis, and Attenuates Emotional and Olfactory Dysfunctions in Chronic Corticosterone-Induced Depression.
Topics: Adaptor Proteins, Signal Transducing; Animals; Anxiety; Behavior, Animal; Brain; Cell Line, Tumor; C | 2018 |
Axonal transport proteins and depressive like behavior, following Chronic Unpredictable Mild Stress in male rat.
Topics: Animals; Apoptosis; Axonal Transport; Cell Count; Corticosterone; Depression; Dyneins; Hippocampus; | 2018 |
Liraglutide attenuates the depressive- and anxiety-like behaviour in the corticosterone induced depression model via improving hippocampal neural plasticity.
Topics: Alzheimer Disease; Animals; Antidepressive Agents; Anxiety; Corticosterone; Depression; Depressive D | 2018 |
A novel PDE9 inhibitor WYQ-C36D ameliorates corticosterone-induced neurotoxicity and depression-like behaviors by cGMP-CREB-related signaling.
Topics: Animals; Cell Line, Transformed; Cognition Disorders; Corticosterone; CREB-Binding Protein; Cyclic G | 2018 |
Neuroprotective evidence of alpha-lipoic acid and desvenlafaxine on memory deficit in a neuroendocrine model of depression.
Topics: Acetylcholinesterase; Animals; Antidepressive Agents; Behavior, Animal; Brain; Corticosterone; Depre | 2018 |
Targeting β-Catenin in GLAST-Expressing Cells: Impact on Anxiety and Depression-Related Behavior and Hippocampal Proliferation.
Topics: Animals; Anxiety; Behavior, Animal; beta Catenin; Cell Cycle; Cell Proliferation; Corticosterone; De | 2019 |
The effects of enriched environment on the behavioral and corticosterone response to methamphetamine in adolescent and adult mice.
Topics: Age Factors; Animals; Anxiety; Behavior, Animal; Central Nervous System Stimulants; Corticosterone; | 2018 |
Protective Effects of Crocetin on Depression-like Behavior Induced by Immobilization in Rat.
Topics: Animals; Antioxidants; Carotenoids; Corticosterone; Depression; Disease Models, Animal; Exploratory | 2018 |
Effects of prenatal stress on anxiety- and depressive-like behaviours are sex-specific in prepubertal rats.
Topics: Animals; Anxiety; Behavior, Animal; Body Weight; Corticosterone; Depression; Female; Hypothalamo-Hyp | 2018 |
The anxiolytic-like effects of ginsenoside Rg3 on chronic unpredictable stress in rats.
Topics: Adrenocorticotropic Hormone; Animals; Anti-Anxiety Agents; Antineoplastic Agents, Phytogenic; Behavi | 2018 |
High-fructose diet during adolescent development increases neuroinflammation and depressive-like behavior without exacerbating outcomes after stroke.
Topics: Age Factors; Animals; Behavior, Animal; Brain; Corticosterone; Depression; Diet, High-Fat; Disease M | 2018 |
[Anti-depression mechanism of supercritical CO(2) extract from Compound Chaigui Fang based on network pharmacology].
Topics: Animals; Antidepressive Agents; Computational Biology; Corticosterone; Depression; Disease Models, A | 2016 |
The Lateral Habenula Directs Coping Styles Under Conditions of Stress via Recruitment of the Endocannabinoid System.
Topics: Adaptation, Psychological; Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Corticosterone | 2018 |
Sleep patterns deteriorate over time in chronic corticosterone-treated rats.
Topics: Animals; Corticosterone; Depression; Drug Administration Schedule; Electroencephalography; Locus Coe | 2018 |
Profiling changes in cortical astroglial cells following chronic stress.
Topics: Animals; Anxiety; Astrocytes; Chronic Disease; Corticosterone; Depression; Gene Expression; Glial Fi | 2018 |
[Effects of chronic stress depression on the circadian rhythm of peripheral neuroendocrine hormone of rats].
Topics: Animals; Circadian Rhythm; Corticosterone; Depression; Male; Melatonin; Random Allocation; Rats; Rat | 2017 |
Social dominance predicts hippocampal glucocorticoid receptor recruitment and resilience to prenatal adversity.
Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Hippocampus; Hypothalamo-Hypophyseal | 2018 |
Regional alterations of cerebral [
Topics: Animals; Anxiety; Brain; Chronic Disease; Corticosterone; Depression; Disease Models, Animal; Fluori | 2018 |
[Comparative study of the corticosterone and glutamate induced PC12 cells depression model by 1H NMR metabolomics].
Topics: Animals; Antioxidants; Corticosterone; Depression; Depressive Disorder; Fatty Acids; Glutamic Acid; | 2017 |
Cholecalciferol counteracts depressive-like behavior and oxidative stress induced by repeated corticosterone treatment in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Cholecalciferol; Corticosterone; Depression; Disea | 2018 |
Acth-induced model of depression resistant to tricyclic antidepressants: Neuroendocrine and behavioral changes and influence of long-term magnesium administration.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Corticoste | 2018 |
Riparin II ameliorates corticosterone-induced depressive-like behavior in mice: Role of antioxidant and neurotrophic mechanisms.
Topics: Animals; Antidepressive Agents; Antioxidants; Behavior, Animal; Benzamides; Brain-Derived Neurotroph | 2018 |
Early life stress accelerates age-induced effects on neurogenesis, depression, and metabolic risk.
Topics: Age Factors; Animals; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Doubleco | 2018 |
Comparative effects of stressors on behavioral and neuroimmune responses of fawn-hooded (FH/Wjd) and Wistar rats: Implications for models of depression.
Topics: Animals; Brain Chemistry; Corticosterone; Cytokines; Depression; Disease Models, Animal; Hypothalamo | 2018 |
Glucocorticoid receptor activation induces decrease of hippocampal astrocyte number in rats.
Topics: Animals; Astrocytes; Cell Count; Corticosterone; Depression; Glucocorticoids; Hippocampus; Male; Mif | 2018 |
Adiporon, an adiponectin receptor agonist acts as an antidepressant and metabolic regulator in a mouse model of depression.
Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Corticosterone; Cytokines; Depression; Di | 2018 |
Single administration of agmatine reverses the depressive-like behavior induced by corticosterone in mice: Comparison with ketamine and fluoxetine.
Topics: Agmatine; Animals; Antidepressive Agents; Brain; Corticosterone; Depression; Disks Large Homolog 4 P | 2018 |
Antioxidant and antidepressant-like effects of Eugenia catharinensis D. Legrand in an animal model of depression induced by corticosterone.
Topics: Animals; Antidepressive Agents; Antioxidants; Corticosterone; Depression; Disease Models, Animal; Do | 2018 |
Probiotics reduce risk-taking behavior in the Elevated Plus Maze in the Flinders Sensitive Line rat model of depression.
Topics: Animals; Body Weight; Corticosterone; Depression; Dexamethasone; Drinking; Eating; Exploratory Behav | 2019 |
Inhibition of Rho kinase by GSK 269962 reverses both corticosterone-induced detrusor overactivity and depression-like behaviour in rats.
Topics: Animals; Brain-Derived Neurotrophic Factor; Corticosterone; Cytokines; Depression; Female; Imidazole | 2018 |
Maternal separation induces anhedonia in female heterozygous serotonin transporter knockout rats.
Topics: Anhedonia; Animals; Behavior, Animal; Brain; Corticosterone; Depression; Depressive Disorder; Hetero | 2019 |
Chemical Constituents and Antidepressant-Like Effects in Ovariectomized Mice of the Ethanol Extract of
Topics: Amaranthaceae; Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; | 2018 |
The critical role of amygdala subnuclei in nociceptive and depressive-like behaviors in peripheral neuropathy.
Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Basolateral Nuclear Complex; Central Amygdaloid Nucle | 2018 |
Illuminated night alters hippocampal gene expressions and induces depressive-like responses in diurnal corvids.
Topics: Animals; Biomarkers; Brain-Derived Neurotrophic Factor; Circadian Rhythm; Corticosterone; Crows; Dep | 2018 |
Standardized Citrus unshiu peel extract ameliorates dexamethasone-induced neurotoxicity and depressive-like behaviors in mice.
Topics: Animals; Antidepressive Agents; Cell Line, Tumor; Cell Survival; Citrus; Corticosterone; Depression; | 2018 |
Resveratrol and dimethyl fumarate ameliorate depression-like behaviour in a rat model of chronic unpredictable mild stress.
Topics: Animals; Antidepressive Agents; Antioxidants; Apoptosis; beta Catenin; Brain-Derived Neurotrophic Fa | 2018 |
Depression-like behaviors induced by chronic corticosterone exposure via drinking water: Time-course analysis.
Topics: Animals; Behavior, Animal; Corticosterone; Depression; Depressive Disorder; Disease Models, Animal; | 2018 |
Melanin-Concentrating Hormone (MCH) and MCH-R1 in the Locus Coeruleus May Be Involved in the Regulation of Depressive-Like Behavior.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal | 2018 |
Effect of chronic corticosterone-induced depression on circadian rhythms and age-related phenotypes in mice.
Topics: Age Factors; Aging; Animals; Behavior, Animal; Circadian Clocks; Circadian Rhythm; Corticosterone; D | 2018 |
Agarwood Essential Oil Ameliorates Restrain Stress-Induced Anxiety and Depression by Inhibiting HPA Axis Hyperactivity.
Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Brain; Corticosterone; Corticotropin-Releasing Hormon | 2018 |
Quantitative proteomics reveal antidepressant potential protein targets of xiaochaihutang in corticosterone induced model of depression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Drugs, Chinese Herbal; | 2019 |
Chronic histamine 3 receptor antagonism alleviates depression like conditions in mice via modulation of brain-derived neurotrophic factor and hypothalamus-pituitary adrenal axis.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain; Brain-Derived Neurotrophic Factor; Corticos | 2019 |
Antidepressant effect of helicid in chronic unpredictable mild stress model in rats.
Topics: Animals; Antidepressive Agents; Benzaldehydes; Brain-Derived Neurotrophic Factor; Corticosterone; De | 2019 |
Chronic adolescent stress sex-specifically alters central and peripheral neuro-immune reactivity in rats.
Topics: Age Factors; Animals; Anxiety; Anxiety Disorders; Central Nervous System; Corticosterone; Cytokines; | 2019 |
Glucocorticoid receptor deletion from locus coeruleus norepinephrine neurons promotes depression-like social withdrawal in female but not male mice.
Topics: Animals; Antidepressive Agents; Brain; Corticosterone; Depression; Depressive Disorder; Dorsal Raphe | 2019 |
Antidepressant-Like and Neuroprotective Effects of Ethanol Extract from the Root Bark of
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain; Brain-Derived Neurotrophic Factor; Cell Sur | 2018 |
Effects of escitalopram and ibuprofen on a depression-like phenotype induced by chronic stress in rats.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Citalopram; Cor | 2019 |
Role of corticosterone in altered neurobehavioral responses to acute stress in a model of compromised hypothalamic-pituitary-adrenal axis function.
Topics: Animals; Anxiety; Anxiety Disorders; Corticosterone; Depression; Depressive Disorder; Disease Models | 2019 |
Possible role of GLP-1 in antidepressant effects of metformin and exercise in CUMS mice.
Topics: Animals; Antidepressive Agents; bcl-2-Associated X Protein; Corticosterone; Depression; Depressive D | 2019 |
Exposure to Patterned Auditory Stimuli during Acute Stress Prevents Despair-Like Behavior in Adult Mice That Were Previously Housed in an Enriched Environment in Combination with Auditory Stimuli.
Topics: Acoustic Stimulation; Animals; Corticosterone; Depression; Environment; Housing, Animal; Male; Mice; | 2018 |
Antidepressive Effects of Taraxacum Officinale in a Mouse Model of Depression Are Due to Inhibition of Corticosterone Levels and Modulation of Mitogen-Activated Protein Kinase Phosphatase-1 (Mkp-1) and Brain-Derived Neurotrophic Factor (Bdnf) Expression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; | 2019 |
Oxytocin administration prevents cellular aging caused by social isolation.
Topics: Anhedonia; Animals; Arvicolinae; Cellular Senescence; Corticosterone; Depression; Female; Glucocorti | 2019 |
Beneficial Effects of Physical Activity and Crocin Against Adolescent Stress Induced Anxiety or Depressive-Like Symptoms and Dendritic Morphology Remodeling in Prefrontal Cortex in Adult Male Rats.
Topics: Animals; Anxiety; Carotenoids; Combined Modality Therapy; Corticosterone; Dendrites; Depression; Mal | 2019 |
Antidepressant activities of escitalopram and blonanserin on prenatal and adolescent combined stress-induced depression model: Possible role of neurotrophic mechanism change in serum and nucleus accumbens.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Citalopram; Cor | 2019 |
Antidepressant-like activities of live and heat-killed Lactobacillus paracasei PS23 in chronic corticosterone-treated mice and possible mechanisms.
Topics: Animals; Antidepressive Agents; Anxiety; Anxiety Disorders; Behavior, Animal; Brain; Corticosterone; | 2019 |
Selective vulnerability of dorsal raphe-medial prefrontal cortex projection neurons to corticosterone-induced hypofunction.
Topics: Animals; Corticosterone; Depression; Dorsal Raphe Nucleus; Excitatory Postsynaptic Potentials; Genic | 2019 |
DNA methylation of the Tacr2 gene in a CUMS model of depression.
Topics: Animals; Body Weight; Corticosterone; Corticotropin-Releasing Hormone; Depression; Depressive Disord | 2019 |
PINK1 deficiency is associated with increased deficits of adult hippocampal neurogenesis and lowers the threshold for stress-induced depression in mice.
Topics: Animals; Anxiety; Anxiety Disorders; Behavior, Animal; Cell Differentiation; Cell Proliferation; Cor | 2019 |
Tactile Stimulation on Adulthood Modifies the HPA Axis, Neurotrophic Factors, and GFAP Signaling Reverting Depression-Like Behavior in Female Rats.
Topics: Adrenocorticotropic Hormone; Aging; Animals; Behavior, Animal; Body Weight; Corticosterone; Depressi | 2019 |
PET imaging of the mouse brain reveals a dynamic regulation of SERT density in a chronic stress model.
Topics: Aniline Compounds; Animals; Brain; Corticosterone; Depression; Female; Male; Mice, Inbred C57BL; Mic | 2019 |
Ketamine improved depressive-like behaviors via hippocampal glucocorticoid receptor in chronic stress induced- susceptible mice.
Topics: Animals; Anxiety; Corticosterone; Depression; Depressive Disorder; Disease Models, Animal; Gene Expr | 2019 |
Lutein prevents corticosterone-induced depressive-like behavior in mice with the involvement of antioxidant and neuroprotective activities.
Topics: Animals; Antioxidants; Behavior, Animal; Corticosterone; Depression; Fluoxetine; Lutein; Male; Mice; | 2019 |
Acute corticosterone treatment elicits antidepressant-like actions on the hippocampal 5-HT and the immobility phenotype.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain; Brain-Derived Neurotrophic Factor; Corticos | 2019 |
Effects of conditioned social fear on ethanol drinking and vice-versa in male mice.
Topics: Alcohol Drinking; Animals; Anxiety; Corticosterone; Depression; Ethanol; Fear; Interpersonal Relatio | 2019 |
Lavender essential oil ameliorates depression-like behavior and increases neurogenesis and dendritic complexity in rats.
Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Dendrites; Depression; Doublecortin Protein; Lav | 2019 |
Developmental outcomes after gestational antidepressant treatment with sertraline and its discontinuation in an animal model of maternal depression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Depressive Disorder; D | 2019 |
Decreased stress-induced depression-like behavior in lactating rats is associated with changes in the hypothalamic-pituitary-adrenal axis, brain monoamines, and brain amino acid metabolism.
Topics: Adrenocorticotropic Hormone; Amino Acids; Animals; Brain; Catecholamines; Corticosterone; Depression | 2019 |
Faecalibacterium prausnitzii (ATCC 27766) has preventive and therapeutic effects on chronic unpredictable mild stress-induced depression-like and anxiety-like behavior in rats.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Anxiety Disorders; Behavior, Animal; Bone Density; Brain; Bra | 2019 |
The internal link of serum steroid hormones levels in insomnia, depression, and Alzheimer's disease rats: Is there an effective way to distinguish among these three diseases based on potential biomarkers?
Topics: Alzheimer Disease; Animals; Bayes Theorem; Biomarkers; Calibration; Chromatography, High Pressure Li | 2019 |
Protocatechuic acid attenuate depressive-like behavior in olfactory bulbectomized rat model: behavioral and neurobiochemical investigations.
Topics: Animals; Antidepressive Agents; Antioxidants; Behavior, Animal; Corticosterone; Depression; Disease | 2019 |
Effects of corticosterone on the expression of mature brain-derived neurotrophic factor (mBDNF) and proBDNF in the hippocampal dentate gyrus.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Corticosterone; Dentate Gyrus; De | 2019 |
Effects of a selanylimidazopyridine on the acute restraint stress-induced depressive- and anxiety-like behaviors and biological changes in mice.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Animal; Brain-Derived Neurot | 2019 |
Topics: Animals; Animals, Newborn; Anxiety; Corticosterone; Cytokines; Depression; Disease Models, Animal; F | 2019 |
Quercetin mitigates anxiety-like behavior and normalizes hypothalamus-pituitary-adrenal axis function in a mouse model of mild traumatic brain injury.
Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Anxiety Disorders; Brain Concussion; Corticosterone; | 2019 |
Stress-induced neural activation is altered during early withdrawal from chronic methamphetamine.
Topics: Animals; Anxiety; Brain; CA3 Region, Hippocampal; Central Nervous System Stimulants; Corticosterone; | 2019 |
Reversal effect of Riparin IV in depression and anxiety caused by corticosterone chronic administration in mice.
Topics: Amides; Anhedonia; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Animal; B | 2019 |
Comparative pharmacokinetic study of four major bioactive components after oral administration of Zhi-Zi-Hou-Po decoction in normal and corticosterone-induced depressive rats.
Topics: Administration, Oral; Animals; Biphenyl Compounds; Corticosterone; Depression; Disease Models, Anima | 2019 |
The Chinese Herbal Formula PAPZ Ameliorates Behavioral Abnormalities in Depressive Mice.
Topics: Angelica sinensis; Animals; Antidepressive Agents; Antioxidants; Behavior, Animal; Brain-Derived Neu | 2019 |
Transcriptome profiles of corticosterone-induced cytotoxicity reveals the involvement of neurite growth-related genes in depression.
Topics: Animals; Anti-Inflammatory Agents; Cell Survival; Corticosterone; Depression; Male; Neurites; Neurog | 2019 |
Resilience to chronic stress is associated with specific neurobiological, neuroendocrine and immune responses.
Topics: Adaptation, Psychological; Animals; Anxiety; Behavior, Animal; Corticosterone; Corticotropin-Releasi | 2019 |
A Chronic Immobilization Stress Protocol for Inducing Depression-Like Behavior in Mice.
Topics: Animals; Behavior, Animal; Corticosterone; Depression; Diet; Disease Models, Animal; Glutamine; Male | 2019 |
Depression comorbid with hyperalgesia: Different roles of neuroinflammation induced by chronic stress and hypercortisolism.
Topics: Adrenocorticotropic Hormone; Animals; Corticosterone; Depression; Disease Models, Animal; Hippocampu | 2019 |
Effects of Chrysin on Serum Corticosterone Levels and Brain Oxidative Damages Induced by Immobilization in Rat.
Topics: Animals; Brain; Corticosterone; Depression; Flavonoids; Immobilization; Male; Oxidation-Reduction; O | 2020 |
Chronic stress induces hypersensitivity of murine gastric vagal afferents.
Topics: Afferent Pathways; Animals; Anxiety; Blood Glucose; Chronic Disease; Corticosterone; Depression; Exp | 2019 |
Mitochondrial signaling in inflammation-induced depressive behavior in female and male rats: The role of glucocorticoid receptor.
Topics: Animals; Apoptosis; Corticosterone; Depression; Depressive Disorder, Major; Female; Hypothalamo-Hypo | 2019 |
Glucocorticoid receptor antagonism prevents microglia-mediated neuronal remodeling and behavioral despair following chronic unpredictable stress.
Topics: Animals; Behavior, Animal; Brain; Corticosterone; Depression; Hippocampus; Macrophage Colony-Stimula | 2019 |
Antidepressant-like effects of dietary gardenia blue pigment derived from genipin and tyrosine.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Garde | 2019 |
Increased Homer1-mGluR5 mediates chronic stress-induced depressive-like behaviors and glutamatergic dysregulation via activation of PERK-eIF2α.
Topics: Animals; Behavior, Animal; Corticosterone; Depression; Eukaryotic Initiation Factor-2; Excitatory Am | 2019 |
Exposure to jet lag aggravates depression-like behaviors and age-related phenotypes in rats subject to chronic corticosterone.
Topics: Aging; Animals; Behavior, Animal; Corticosterone; Cyclooxygenase 1; Depression; Jet Lag Syndrome; Li | 2019 |
Edaravone presents antidepressant-like activity in corticosterone model of depression in mice with possible role of Fkbp5, Comt, Adora1 and Slc6a15 genes.
Topics: Amino Acid Transport Systems, Neutral; Animals; Antidepressive Agents; Behavior, Animal; Catechol O- | 2019 |
Antidepressant-like effects of 20(S)-protopanaxadiol in a mouse model of chronic social defeat stress and the related mechanisms.
Topics: Animals; Antidepressive Agents; Chronic Disease; Corticosterone; Depression; Disease Models, Animal; | 2019 |
Roman chamomile inhalation combined with clomipramine treatment improves treatment-resistant depression-like behavior in mice.
Topics: Animals; Behavior, Animal; Cell Proliferation; Chamaemelum; Clomipramine; Corticosterone; Cytokines; | 2019 |
The effect of fluoxetine on astrocyte autophagy flux and injured mitochondria clearance in a mouse model of depression.
Topics: Animals; Antidepressive Agents; Astrocytes; Autophagosomes; Autophagy; Corticosterone; Depression; D | 2019 |
Effect of co-treatment with fluoxetine or mirtazapine and risperidone on the active behaviors and plasma corticosterone concentration in rats subjected to the forced swim test.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Antipsychotic A | 2012 |
Glucocorticoids orchestrate divergent effects on mood through adult neurogenesis.
Topics: Adaptation, Psychological; Adrenalectomy; Affect; Animals; Antimetabolites; Behavior, Animal; Bromod | 2013 |
Prenatal exposure to escitalopram and/or stress in rats: a prenatal stress model of maternal depression and its treatment.
Topics: Animals; Citalopram; Corticosterone; Darkness; Depression; Disease Models, Animal; Female; Infusion | 2013 |
[Antidepressant activities of flavonoids from Glycyrrhiza uralensis and its neurogenesis protective effect in rats].
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bromodeoxyuridine; Corticosterone; Depression; Fla | 2012 |
Antidepressant-like effect of macranthol isolated from Illicium dunnianum tutch in mice.
Topics: Alkenes; Animals; Antidepressive Agents; Corticosterone; Depression; Disease Models, Animal; Dose-Re | 2013 |
Augmentation therapy with alpha-lipoic acid and desvenlafaxine: a future target for treatment of depression?
Topics: Animals; Antidepressive Agents; Antioxidants; Behavior, Animal; Corticosterone; Cyclohexanols; Depre | 2013 |
Suppression of neuroinflammatory and apoptotic signaling cascade by curcumin alone and in combination with piperine in rat model of olfactory bulbectomy induced depression.
Topics: Alkaloids; Animals; Apoptosis; Benzodioxoles; Brain; Brain-Derived Neurotrophic Factor; Caspase 3; C | 2013 |
Imbalance of leptin pathway and hypothalamus synaptic plasticity markers are associated with stress-induced depression in rats.
Topics: Animals; Biomarkers; Corticosterone; Depression; Hypothalamo-Hypophyseal System; Hypothalamus; Lepti | 2013 |
Behavioral deficits, abnormal corticosterone, and reduced prefrontal metabolites of adolescent rats subject to early life stress.
Topics: Aging; Animals; Corticosterone; Depression; Female; Male; Maternal Deprivation; Mental Disorders; Pr | 2013 |
[Effect of hesperidin on behavior and HPA axis of rat model of chronic stress-induced depression].
Topics: Administration, Oral; Animals; Behavior, Animal; Corticosterone; Corticotropin-Releasing Hormone; De | 2013 |
Role of prefrontal cortex glucocorticoid receptors in stress and emotion.
Topics: Adrenocorticotropic Hormone; Affect; Animals; Cells, Cultured; Corticosterone; Depression; Emotions; | 2013 |
Neonatal NMDA receptor blockade alters anxiety- and depression-related behaviors in a sex-dependent manner in mice.
Topics: Age Factors; Animals; Animals, Newborn; Anxiety; Behavior, Animal; Body Weight; Corticosterone; Depr | 2013 |
Disruption of circadian rhythms due to chronic constant light leads to depressive and anxiety-like behaviors in the rat.
Topics: Analysis of Variance; Animals; Anxiety; Body Weight; Cell Count; Chronobiology Disorders; Corticoste | 2013 |
The effects of a standardized Acanthopanax koreanum extract on stress-induced behavioral alterations in mice.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Animal; Corticosterone; Depr | 2013 |
Being suckled in a large litter mitigates the effects of early-life stress on hypothalamic-pituitary-adrenal axis function in the male rat.
Topics: Animals; Anxiety; Body Composition; Body Weight; Corticosterone; Depression; Female; Hypothalamo-Hyp | 2013 |
Depression-like behavior in subclinical hypothyroidism rat induced by hemi-thyroid electrocauterization.
Topics: Adrenal Cortex; Animals; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Elect | 2014 |
Differential impact of a complex environment on positive affect in an animal model of individual differences in emotionality.
Topics: Affect; Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Envi | 2013 |
Orcinol glucoside produces antidepressant effects by blocking the behavioural and neuronal deficits caused by chronic stress.
Topics: Animals; Antidepressive Agents; Chronic Disease; Corticosterone; Corticotropin-Releasing Hormone; De | 2014 |
Systematic correlation between spine plasticity and the anxiety/depression-like phenotype induced by corticosterone in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; CA1 Region, Hippocampal; Corticosterone; Dendritic | 2013 |
Mood and memory function in ovariectomised rats exposed to social instability stress.
Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Corticosterone; Depression; Estradiol; Memory; Ovarie | 2013 |
Effects of palmitoylethanolamide and luteolin in an animal model of anxiety/depression.
Topics: Amides; Animals; Antidepressive Agents; Anxiety; Apoptosis; Behavior, Animal; Brain; Brain-Derived N | 2013 |
Effects of corticosterone and amyloid-beta on proteins essential for synaptic function: implications for depression and Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Anti-Inflammatory Agents; Autophagy; Blotting, Western; Ce | 2013 |
Zinc deficiency alters responsiveness to antidepressant drugs in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Diet; Disease Models, | 2013 |
Inactivation of glucocorticoid receptor in noradrenergic system influences anxiety- and depressive-like behavior in mice.
Topics: Adrenergic Neurons; Animals; Anxiety Disorders; Behavior, Animal; Chronic Disease; Corticosterone; D | 2013 |
Anxiety- and depression-like behavior are correlated with leptin and leptin receptor expression in prefrontal cortex of streptozotocin-induced diabetic rats.
Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Diabetes Mellitus, Experimental; Dis | 2014 |
High novelty-seeking rats are resilient to negative physiological effects of the early life stress.
Topics: Adrenocorticotropic Hormone; Animals; Animals, Newborn; Anxiety; Behavior, Animal; Corticosterone; D | 2014 |
Female rats exposed to stress and alcohol show impaired memory and increased depressive-like behaviors.
Topics: Alcohols; Analysis of Variance; Animals; Body Weight; Corticosterone; Depression; Disease Models, An | 2014 |
Estradiol decreases rat depressive behavior by estrogen receptor beta but not alpha: no correlation with plasma corticosterone.
Topics: Animals; Corticosterone; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Estra | 2014 |
Antidepressant-like effects of the aqueous macerate of the bulb of Gladiolus dalenii Van Geel (Iridaceae) in a rat model of epilepsy-associated depression.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Epile | 2013 |
Disruption of social bonds induces behavioral and physiological dysregulation in male and female prairie voles.
Topics: Adrenocorticotropic Hormone; Animals; Arvicolinae; Atenolol; Atropine; Autonomic Nervous System; Ber | 2014 |
Antidepressant-like activity of turmerone in behavioral despair tests in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Curcuma; Depression; Drugs, Chines | 2013 |
Agmatine attenuates chronic unpredictable mild stress induced behavioral alteration in mice.
Topics: Agmatine; Animals; Antidepressive Agents; Behavior, Animal; Body Weight; Corticosterone; Depression; | 2013 |
[Mifepristone repairs alteration of learning and memory abilities in rat model of depression].
Topics: Animals; Behavior, Animal; Corticosterone; Depression; Hippocampus; Learning; Male; Memory; Mifepris | 2013 |
The effect of chronic administration of corticosterone on anxiety- and depression-like behavior and the expression of GABA-A receptor alpha-2 subunits in brain structures of low- and high-anxiety rats.
Topics: Amygdala; Animals; Anxiety; Behavior, Animal; Brain Chemistry; Corticosterone; Depression; Emotions; | 2014 |
An organoselenium compound improves behavioral, endocrinal and neurochemical changes induced by corticosterone in mice.
Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Disease | 2014 |
Strain-dependent effects of prenatal maternal immune activation on anxiety- and depression-like behaviors in offspring.
Topics: Animals; Animals, Outbred Strains; Anxiety; Corticosterone; Depression; Female; Interleukin-6; Lipop | 2014 |
All-trans retinoic acid-induced hypothalamus-pituitary-adrenal hyperactivity involves glucocorticoid receptor dysregulation.
Topics: Animals; Behavior, Animal; Corticosterone; Corticotropin-Releasing Hormone; Depression; Dexamethason | 2013 |
Depression-like behaviors in mice subjected to co-treatment of high-fat diet and corticosterone are ameliorated by AICAR and exercise.
Topics: Aminoimidazole Carboxamide; Animals; Corticosterone; Depression; Depressive Disorder; Diet, High-Fat | 2014 |
Tumor necrosis factor-alpha during neonatal brain development affects anxiety- and depression-related behaviors in adult male and female mice.
Topics: Animals; Animals, Newborn; Anxiety; Body Weight; Brain; Corticosterone; Cytokines; Dark Adaptation; | 2014 |
Urtica dioica extract attenuates depressive like behavior and associative memory dysfunction in dexamethasone induced diabetic mice.
Topics: Animals; Antidepressive Agents; Association Learning; Avoidance Learning; Blood Glucose; Corticoster | 2014 |
Soyo-san reduces depressive-like behavior and proinflammatory cytokines in ovariectomized female rats.
Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents; Brain; Corticosterone; Cytokines; Depressi | 2014 |
Chronic unpredictable mild stress impairs erythrocyte immune function and changes T-lymphocyte subsets in a rat model of stress-induced depression.
Topics: Animals; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Drinking; Erythrocyte | 2014 |
Loss of Gabrd in CRH neurons blunts the corticosterone response to stress and diminishes stress-related behaviors.
Topics: Animals; Anxiety; Behavior, Animal; Brain; Corticosterone; Corticotropin-Releasing Hormone; Depressi | 2014 |
Maternal separation modifies behavioural and neuroendocrine responses to stress in CCR7 deficient mice.
Topics: Animals; Animals, Newborn; Anxiety; Body Weight; Corticosterone; Depression; Exploratory Behavior; F | 2014 |
Hippocampal dysfunctions in tumor-bearing mice.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Line, Tumor; Corticosterone; Cyclooxygenase 2; Cyto | 2014 |
Enhancement of BDNF concentration and restoration of the hypothalamic-pituitary-adrenal axis accompany reduced depressive-like behaviour in stressed ovariectomised rats treated with either Tualang honey or estrogen.
Topics: Adrenocorticotropic Hormone; Animals; Behavior, Animal; Body Weight; Brain-Derived Neurotrophic Fact | 2014 |
A neuroendocrine mechanism of co-morbidity of depression-like behavior and myocardial injury in rats.
Topics: Animals; Apoptosis; Body Weight; Cardiomyopathies; Cells, Cultured; Comorbidity; Corticosterone; Dep | 2014 |
Mice deficient in phosphodiesterase-4A display anxiogenic-like behavior.
Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Cyclic Nucleotide Phosphodiesterases, Type 4; De | 2014 |
Effects of brief pulse and ultrabrief pulse electroconvulsive stimulation on rodent brain and behaviour in the corticosterone model of depression.
Topics: Adrenal Glands; Analysis of Variance; Animals; Anti-Inflammatory Agents; Body Weight; Brain-Derived | 2014 |
Iptakalim confers an antidepressant effect in a chronic mild stress model of depression through regulating neuro-inflammation and neurogenesis.
Topics: Animals; Antidepressive Agents; Body Weight; Bromodeoxyuridine; Cell Count; Corticosterone; Cytokine | 2014 |
Antidepressant and anxiolytic profiles of newly synthesized arginine vasopressin V1B receptor antagonists: TASP0233278 and TASP0390325.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Antidepressive Agents; Antidiuretic Hormone Rece | 2014 |
Glucocorticoid receptor deletion from the dorsal raphé nucleus of mice reduces dysphoria-like behavior and impairs hypothalamic-pituitary-adrenocortical axis feedback inhibition.
Topics: Adaptation, Psychological; Animals; Anxiety; Circadian Rhythm; Corticosterone; Depression; Dominance | 2014 |
Social defeat stress induces a depression-like phenotype in adolescent male c57BL/6 mice.
Topics: Aging; Animals; Anxiety; Corticosterone; Depression; Depressive Disorder; Dietary Carbohydrates; Dom | 2014 |
Protracted effects of juvenile stressor exposure are mitigated by access to palatable food.
Topics: Adiposity; Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Diet, High-Fat; Energy In | 2014 |
Enkephalin knockout male mice are resistant to chronic mild stress.
Topics: Animals; Anxiety; Corticosterone; Depression; Enkephalins; Hypothalamus; Male; Maze Learning; Mice; | 2014 |
The effects of neonatal cryoanaesthesia-induced hypothermia on adult emotional behaviour and stress markers in C57BL/6 mice.
Topics: Aging; Animals; Animals, Newborn; Anxiety; Biomarkers; Brain-Derived Neurotrophic Factor; Corticoste | 2014 |
Long-term effects of controllability or the lack of it on coping abilities and stress resilience in the rat.
Topics: Adaptation, Psychological; Animals; Anxiety; Avoidance Learning; Behavior, Animal; Corticosterone; D | 2014 |
Witnessing traumatic events causes severe behavioral impairments in rats.
Topics: Animals; Anxiety; Corticosterone; Depression; Disease Models, Animal; Dominance-Subordination; Housi | 2014 |
Pycnogenol ameliorates depression-like behavior in repeated corticosterone-induced depression mice model.
Topics: Animals; Antioxidants; Corticosterone; Depression; Depressive Disorder; Disease Models, Animal; Flav | 2014 |
Long-term differential effects of chronic young-adult corticosterone exposure on anxiety and depression-like behaviour in BDNF heterozygous rats depend on the experimental paradigm used.
Topics: Animals; Anxiety; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Genotype; Heterozyg | 2014 |
5HT3 receptor antagonist (ondansetron) reverses depressive behavior evoked by chronic unpredictable stress in mice: modulation of hypothalamic-pituitary-adrenocortical and brain serotonergic system.
Topics: Adrenal Cortex; Animals; Behavior, Animal; Brain; Corticosterone; Depression; Hypothalamo-Hypophysea | 2014 |
Simvastatin treatment exerts antidepressant-like effect in rats exposed to chronic mild stress.
Topics: Animals; Behavior, Animal; Corticosterone; Depression; Hydroxymethylglutaryl-CoA Reductase Inhibitor | 2014 |
Emodin opposes chronic unpredictable mild stress induced depressive-like behavior in mice by upregulating the levels of hippocampal glucocorticoid receptor and brain-derived neurotrophic factor.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; | 2014 |
Neuropathic pain-induced depressive-like behavior and hippocampal neurogenesis and plasticity are dependent on TNFR1 signaling.
Topics: Anhedonia; Animals; Corticosterone; Depression; Drinking Behavior; Exploratory Behavior; Food Prefer | 2014 |
Correlations between depression behaviors and sleep parameters after repeated corticosterone injections in rats.
Topics: Animals; Corticosterone; Depression; Male; Rats; Rats, Sprague-Dawley; Sleep; Sleep Wake Disorders; | 2014 |
Possible involvement of corticosterone and serotonin in antidepressant and antianxiety effects of chromium picolinate in chronic unpredictable mild stress induced depression and anxiety in rats.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Brain; Chronic Disease; Corticosterone | 2015 |
Development of behavioral and hormonal disorders in prenatally stressed female rats on the model of posttraumatic stress disorder.
Topics: Animals; Anxiety; Corticosterone; Depression; Female; Pregnancy; Prenatal Exposure Delayed Effects; | 2014 |
Brain organic cation transporter 2 controls response and vulnerability to stress and GSK3β signaling.
Topics: Action Potentials; Acute Disease; Animals; Brain; Chronic Disease; Corticosterone; Depression; Glyco | 2015 |
Behavioral effects of glucocorticoids during the first exposures to the forced swim stress.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Dexamethasone; Enzyme | 2015 |
Chronic high-fat diet increases acute neuroendocrine stress response independently of prenatal dexamethasone treatment in male rats.
Topics: Animals; Blood Glucose; Corticosterone; Depression; Dexamethasone; Diet, High-Fat; Disease Models, A | 2014 |
The antidepressant effects of ginseng total saponins in male C57BL/6N mice by enhancing hippocampal inhibitory phosphorylation of GSK-3β.
Topics: Animals; Antidepressive Agents; Corticosterone; Depression; Disease Models, Animal; Down-Regulation; | 2014 |
Prevention of 5-hydroxytryptamine2C receptor RNA editing and alternate splicing in C57BL/6 mice activates the hypothalamic-pituitary-adrenal axis and alters mood.
Topics: Affect; Alternative Splicing; Animals; Circadian Rhythm; Corticosterone; Corticotropin-Releasing Hor | 2014 |
Lipopolysaccharide repeated challenge followed by chronic mild stress protocol introduces a combined model of depression in rats: reversibility by imipramine and pentoxifylline.
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Corticosterone; Depression; Disease Mod | 2014 |
Effects of N-acetylcysteine and imipramine in a model of acute rhythm disruption in BALB/c mice.
Topics: Acetylcysteine; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Circadian Rhythm; Corti | 2015 |
GABAB(1) receptor subunit isoforms differentially regulate stress resilience.
Topics: Anhedonia; Animals; Behavior, Animal; Cell Proliferation; Corticosterone; Depression; Disease Models | 2014 |
Long-term corticosterone exposure decreases insulin sensitivity and induces depressive-like behaviour in the C57BL/6NCrl mouse.
Topics: Animals; Behavior, Animal; Blood Glucose; Corticosterone; Depression; Disease Models, Animal; Hypoth | 2014 |
Folic acid prevents depressive-like behavior induced by chronic corticosterone treatment in mice.
Topics: Animals; Antidepressive Agents; Corticosterone; Depression; Drug Administration Schedule; Female; Fo | 2014 |
WY14643 produces anti-depressant-like effects in mice via the BDNF signaling pathway.
Topics: Animals; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Depressive Disorder; Hindlim | 2015 |
Antidepressant-like effects of a novel 5-HT3 receptor antagonist 6z in acute and chronic murine models of depression.
Topics: Acute Disease; Animals; Antidepressive Agents; Antioxidants; Behavior, Animal; Benzothiazoles; Bioma | 2014 |
Early-life stress selectively affects gastrointestinal but not behavioral responses in a genetic model of brain-gut axis dysfunction.
Topics: Animals; Anxiety; Brain; Colon; Corticosterone; Depression; Disease Models, Animal; Female; Gastroin | 2015 |
Insulin-like growth factor 2 mitigates depressive behavior in a rat model of chronic stress.
Topics: Animals; Body Weight; Chronic Disease; Corticosterone; Depression; Disease Models, Animal; Food Pref | 2015 |
Honokiol abrogates lipopolysaccharide-induced depressive like behavior by impeding neuroinflammation and oxido-nitrosative stress in mice.
Topics: Animals; Antidepressive Agents; Biphenyl Compounds; Brain-Derived Neurotrophic Factor; Corticosteron | 2014 |
Social overcrowding as a chronic stress model that increases adiposity in mice.
Topics: Adiponectin; Adiposity; Animals; Anxiety; Behavior, Animal; Body Weight; Corticosterone; Crowding; D | 2015 |
Chronic corticosterone exposure reduces hippocampal glycogen level and induces depression-like behavior in mice.
Topics: Animals; Astrocytes; Behavior, Animal; Brain; Corticosterone; Depression; Disease Models, Animal; Gl | 2015 |
Chronic all-trans retinoic acid administration induces CRF over-expression accompanied by AVP up-regulation and multiple CRF-controlling receptors disturbance in the hypothalamus of rats.
Topics: Animals; Arginine Vasopressin; Corticosterone; Corticotropin-Releasing Hormone; Depression; Disease | 2015 |
GPR39 (zinc receptor) knockout mice exhibit depression-like behavior and CREB/BDNF down-regulation in the hippocampus.
Topics: Animals; Brain-Derived Neurotrophic Factor; Corticosterone; CREB-Binding Protein; Dark Adaptation; D | 2014 |
Effect of a novel 5-HT3 receptor antagonist 4i, in corticosterone-induced depression-like behavior and oxidative stress in mice.
Topics: Animals; Behavior, Animal; Catalase; Corticosterone; Depression; Glutathione; Hypothalamus; Lipid Pe | 2015 |
Imipramine protects against the deleterious effects of chronic corticosterone on depression-like behavior, hippocampal reelin expression, and neuronal maturation.
Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents, Tricyclic; Cell Adhesion Molecules, Neuron | 2015 |
Hypothalamic-pituitary-adrenal axis and behavioral dysfunction following early binge-like prenatal alcohol exposure in mice.
Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Behavior, Animal; Binge Drinking; Central Nervous Sys | 2015 |
Chronic corticosterone exposure reduces hippocampal astrocyte structural plasticity and induces hippocampal atrophy in mice.
Topics: Animals; Astrocytes; Atrophy; Corticosterone; Depression; Glial Fibrillary Acidic Protein; Hippocamp | 2015 |
Effect of chronic corticosterone application on depression-like behavior in C57BL/6N and C57BL/6J mice.
Topics: Animals; Behavior, Animal; Corticosterone; Depression; Male; Mice; Mice, Inbred C57BL | 2015 |
Lack of stress responses to long-term effects of corticosterone in Caps2 knockout mice.
Topics: Animals; Anxiety; Behavior, Animal; Body Weight; Calcium-Binding Proteins; Corticosterone; Depressio | 2015 |
Prenatal maternal immune activation increases anxiety- and depressive-like behaviors in offspring with experimental autoimmune encephalomyelitis.
Topics: Animals; Anxiety; Anxiety Disorders; Behavior, Animal; Corticosterone; Depression; Encephalomyelitis | 2015 |
Increasing Adult Hippocampal Neurogenesis is Sufficient to Reduce Anxiety and Depression-Like Behaviors.
Topics: Animals; Anxiety; bcl-2-Associated X Protein; Bromodeoxyuridine; Corticosterone; Depression; Disease | 2015 |
Subchronic administration of riparin III induces antidepressive-like effects and increases BDNF levels in the mouse hippocampus.
Topics: Anhedonia; Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Benzamides; Brain-Derived Neur | 2015 |
Antidepressant-like effects of oleoylethanolamide in a mouse model of chronic unpredictable mild stress.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Antioxidants; Atrophy; Brain-Derived Ne | 2015 |
Long-term effects of early adolescent stress: dysregulation of hypothalamic-pituitary-adrenal axis and central corticotropin releasing factor receptor 1 expression in adult male rats.
Topics: Animals; Anxiety; Corticosterone; Depression; Disease Models, Animal; Electroshock; Exercise Therapy | 2015 |
Neurogenesis-independent antidepressant-like effects of enriched environment is dependent on adiponectin.
Topics: Adiponectin; Animal Welfare; Animals; Anxiety; Behavior Rating Scale; Behavior, Animal; Corticostero | 2015 |
Mice age - Does the age of the mother predict offspring behaviour?
Topics: Adaptation, Ocular; Age Factors; Aging; Animals; Anxiety; Corticosterone; Depression; Disease Models | 2015 |
Nrf2-signaling and BDNF: A new target for the antidepressant-like activity of chronic fluoxetine treatment in a mouse model of anxiety/depression.
Topics: Animals; Antidepressive Agents; Anxiety; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Cortico | 2015 |
LC-MS/MS based studies on the anti-depressant effect of hypericin in the chronic unpredictable mild stress rat model.
Topics: Amino Acids; Animals; Anthracenes; Antidepressive Agents; Behavior, Animal; Chromatography, Liquid; | 2015 |
Agmatine, by Improving Neuroplasticity Markers and Inducing Nrf2, Prevents Corticosterone-Induced Depressive-Like Behavior in Mice.
Topics: Agmatine; Anhedonia; Animals; Antidepressive Agents; Astrocytes; Behavior, Animal; Biomarkers; Corti | 2016 |
Activation of GABA-A receptors during postnatal brain development increases anxiety- and depression-related behaviors in a time- and dose-dependent manner in adult mice.
Topics: Animals; Animals, Newborn; Anxiety; Bicuculline; Brain; Corticosterone; Depression; Dose-Response Re | 2015 |
m-Trifluoromethyl-diphenyl diselenide, a multi-target selenium compound, prevented mechanical allodynia and depressive-like behavior in a mouse comorbid pain and depression model.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Brain; Corticosterone; Cytokines; Depre | 2015 |
Ketamine as a Prophylactic Against Stress-Induced Depressive-like Behavior.
Topics: Animals; Antidepressive Agents; Anxiety; Corticosterone; Depression; Fear; Helplessness, Learned; Ke | 2016 |
Resveratrol ameliorates depressive-like behavior in repeated corticosterone-induced depression in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; | 2015 |
Venlafaxine reverses decreased proliferation in the subventricular zone in a rat model of early life stress.
Topics: Animals; Behavior, Animal; Cell Proliferation; Cognition Disorders; Corticosterone; Depression; Late | 2015 |
Effects of nitric oxide synthesis inhibitor or fluoxetine treatment on depression-like state and cardiovascular changes induced by chronic variable stress in rats.
Topics: Animals; Antidepressive Agents; Autonomic Nervous System; Baroreflex; Behavior, Animal; Cardiovascul | 2015 |
Mice heterozygous for cathepsin D deficiency exhibit mania-related behavior and stress-induced depression.
Topics: Adaptation, Ocular; Animals; Antidepressive Agents; Bipolar Disorder; Cathepsin D; Corticosterone; D | 2015 |
Therapeutic antidepressant potential of a conjugated siRNA silencing the serotonin transporter after intranasal administration.
Topics: Administration, Intranasal; Animals; Antidepressive Agents; Arabidopsis Proteins; Brain; Corticoster | 2016 |
Antidepressant-like effect of simvastatin in diabetic rats.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Clomipramine; Corticosterone; Depression; Diabetes | 2015 |
Angelica gigas ameliorate depression-like symptoms in rats following chronic corticosterone injection.
Topics: Angelica; Animals; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Male; Plant | 2015 |
Phosphodiesterase-4D Knock-down in the Prefrontal Cortex Alleviates Chronic Unpredictable Stress-Induced Depressive-Like Behaviors and Memory Deficits in Mice.
Topics: Animals; Body Weight; Corticosterone; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cycli | 2015 |
Alterations in circadian entrainment precede the onset of depression-like behavior that does not respond to fluoxetine.
Topics: Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Circadian Rhythm; Corticosteron | 2015 |
Circadian variations in behaviors, BDNF and cell proliferation in depressive mice.
Topics: Anhedonia; Animals; Behavior, Animal; Body Weight; Brain-Derived Neurotrophic Factor; Cell Prolifera | 2015 |
Ondansetron attenuates co-morbid depression and anxiety associated with obesity by inhibiting the biochemical alterations and improving serotonergic neurotransmission.
Topics: Animals; Anxiety; Behavior, Animal; Body Weight; Brain; Citalopram; Corticosterone; Depression; Diet | 2015 |
Enriched environment decreases microglia and brain macrophages inflammatory phenotypes through adiponectin-dependent mechanisms: Relevance to depressive-like behavior.
Topics: Adiponectin; Animals; Corticosterone; Cytokines; Depression; Encephalitis; Environment; Hippocampus; | 2015 |
Antidepressant-like effects of quercetin in diabetic rats are independent of hypothalamic-pituitary-adrenal axis.
Topics: Adrenocorticotropic Hormone; Animals; Antibiotics, Antineoplastic; Antidepressive Agents; Antioxidan | 2016 |
MeCP2 controls hippocampal brain-derived neurotrophic factor expression via homeostatic interactions with microRNA‑132 in rats with depression.
Topics: Animals; Brain-Derived Neurotrophic Factor; Case-Control Studies; Corticosterone; Depression; Depres | 2015 |
Calcitonin gene-related peptide pre-administration acts as a novel antidepressant in stressed mice.
Topics: Animals; Antidepressive Agents; Calcitonin Gene-Related Peptide; Cell Line; Corticosterone; Depressi | 2015 |
Mice undergoing neuropathic pain induce anxiogenic-like effects and hypernociception in cagemates.
Topics: Animals; Anxiety; Corticosterone; Depression; Dietary Sucrose; Male; Mice; Neuralgia; Nociceptive Pa | 2015 |
Antidepressant-Like Effects of Sanggenon G, Isolated from the Root Bark of Morus alba, in Rats: Involvement of the Serotonergic System.
Topics: Animals; Antidepressive Agents; Benzofurans; Chromones; Corticosterone; Depression; Hypothalamo-Hypo | 2015 |
ATP-sensitive potassium channels: uncovering novel targets for treating depression.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Count; Cell Survival; Corticosterone; Depression; H | 2016 |
Acute, but not chronic, stress increased the plasma concentration and hypothalamic mRNA expression of NUCB2/nesfatin-1 in rats.
Topics: Animals; Calcium-Binding Proteins; Corticosterone; Depression; DNA-Binding Proteins; Hypothalamus; M | 2015 |
TrkB in the hippocampus and nucleus accumbens differentially modulates depression-like behavior in mice.
Topics: Animals; Anxiety; Astrocytes; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; | 2016 |
Prenatal stress programs neuroendocrine stress responses and affective behaviors in second generation rats in a sex-dependent manner.
Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Behavior, Animal; Corticosterone; Corticotropin-Relea | 2015 |
Beneficial Effects of Highly Palatable Food on the Behavioral and Neural Adversities induced by Early Life Stress Experience in Female Rats.
Topics: Animals; Anxiety; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; F | 2015 |
Behavioural and neurobiological consequences of macrophage migration inhibitory factor gene deletion in mice.
Topics: Animals; Biogenic Monoamines; Corticosterone; Cytokines; Depression; Disease Models, Animal; Explora | 2015 |
Reversal of corticosterone-induced BDNF alterations by the natural antioxidant alpha-lipoic acid alone and combined with desvenlafaxine: Emphasis on the neurotrophic hypothesis of depression.
Topics: Animals; Antidepressive Agents; Antioxidants; Brain-Derived Neurotrophic Factor; Corticosterone; Dep | 2015 |
Depressive-like phenotype induced by AAV-mediated overexpression of human α-synuclein in midbrain dopaminergic neurons.
Topics: Adrenocorticotropic Hormone; alpha-Synuclein; Animals; Corticosterone; Dependovirus; Depression; Dis | 2015 |
Antidepressant-like activity of plumbagin in unstressed and stressed mice.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Antioxidants; Behavior, Animal; Br | 2015 |
Administration of Lactobacillus helveticus NS8 improves behavioral, cognitive, and biochemical aberrations caused by chronic restraint stress.
Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Behavior, Animal; Body Weight; Brain-Derived Neurotro | 2015 |
H2S protects PC12 cells against toxicity of corticosterone by modulation of BDNF-TrkB pathway.
Topics: Animals; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Hydrogen Sulfide; Membrane G | 2015 |
Despair-associated memory requires a slow-onset CA1 long-term potentiation with unique underlying mechanisms.
Topics: Animals; CA1 Region, Hippocampal; Corticosterone; Depression; Dizocilpine Maleate; Excitatory Amino | 2015 |
Neonatal tactile stimulation decreases depression-like and anxiety-like behaviors and potentiates sertraline action in young rats.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Anxiety; Corticosterone; Depression; D | 2015 |
Tris-(2,3-Dibromopropyl) Isocyanurate, a New Emerging Pollutant, Impairs Cognition and Provokes Depression-Like Behaviors in Adult Rats.
Topics: Adrenocorticotropic Hormone; Animals; Behavior, Animal; Biomarkers; Brain-Derived Neurotrophic Facto | 2015 |
Enzymatic Depletion of the Polysialic Acid Moiety Associated with the Neural Cell Adhesion Molecule Inhibits Antidepressant Efficacy.
Topics: Animals; Antidepressive Agents, Second-Generation; Corticosterone; Depression; Disease Models, Anima | 2016 |
Sex-related effects of sleep deprivation on depressive- and anxiety-like behaviors in mice.
Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Eating; Female; Locomotion; Male; Mi | 2016 |
Effectiveness of different corticosterone administration methods to elevate corticosterone serum levels, induce depressive-like behavior, and affect neurogenesis levels in female rats.
Topics: Animals; Behavior, Animal; Body Weight; Corticosterone; Dentate Gyrus; Depression; Disease Models, A | 2016 |
SLC6A15, a novel stress vulnerability candidate, modulates anxiety and depressive-like behavior: involvement of the glutamatergic system.
Topics: Alleles; Amino Acid Transport Systems, Neutral; Animals; Anxiety; Behavior, Animal; Corticosterone; | 2016 |
Antidepressant-like effect of the water extract of the fixed combination of Gardenia jasminoides, Citrus aurantium and Magnolia officinalis in a rat model of chronic unpredictable mild stress.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Citr | 2015 |
Lipopolysaccharide induced anxiety- and depressive-like behaviour in mice are prevented by chronic pre-treatment of esculetin.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Anxiety; Behavior, Animal; Corticosterone; Depressi | 2016 |
Myricetin Attenuates Depressant-Like Behavior in Mice Subjected to Repeated Restraint Stress.
Topics: Animals; Antidepressive Agents; Antioxidants; Behavior, Animal; Brain-Derived Neurotrophic Factor; C | 2015 |
Creatine, Similar to Ketamine, Counteracts Depressive-Like Behavior Induced by Corticosterone via PI3K/Akt/mTOR Pathway.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; | 2016 |
In-depth behavioral characterization of the corticosterone mouse model and the critical involvement of housing conditions.
Topics: Animals; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Exploratory Behavior; | 2016 |
Effects of Escitalopram on a Rat Model of Persistent Stress-Altered Hedonic Activities: Towards a New Understanding of Stress and Depression.
Topics: Age Factors; Animals; Antidepressive Agents, Second-Generation; Citalopram; Corticosterone; Depressi | 2015 |
Tempol protects sleep-deprivation induced behavioral deficits in aggressive male Long-Evans rats.
Topics: Aggression; Aging; Animals; Antioxidants; Anxiety; Behavior, Animal; Corticosterone; Cyclic N-Oxides | 2016 |
Rhythmical Photic Stimulation at Alpha Frequencies Produces Antidepressant-Like Effects in a Mouse Model of Depression.
Topics: Animals; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Fluoxetine; Male; Mic | 2016 |
Anxiety- and Depression-Like States Lead to Pronounced Olfactory Deficits and Impaired Adult Neurogenesis in Mice.
Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents, Second-Generation; Anxiety; Cell Prolifera | 2016 |
Berberine up-regulates the BDNF expression in hippocampus and attenuates corticosterone-induced depressive-like behavior in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Berberine; Brain-Derived Neurotrophic Factor; Cort | 2016 |
Electroacupuncture regulate hypothalamic-pituitary-adrenal axis and enhance hippocampal serotonin system in a rat model of depression.
Topics: Adrenocorticotropic Hormone; Animals; Corticosterone; Corticotropin-Releasing Hormone; Depression; E | 2016 |
Testosterone has antidepressant-like efficacy and facilitates imipramine-induced neuroplasticity in male rats exposed to chronic unpredictable stress.
Topics: Animals; Antidepressive Agents; Chronic Disease; Corticosterone; Dentate Gyrus; Depression; Disease | 2016 |
Opposite Sex Contact and Isolation: A Novel Depression/Anxiety Model.
Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Cyclic AMP Response Element-Binding Protein; Dep | 2016 |
Effect of Inhaling Bergamot Oil on Depression-Related Behaviors in Chronic Stressed Rats.
Topics: Animals; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Depressive Disorder; Hippoca | 2015 |
Apigenin reverses depression-like behavior induced by chronic corticosterone treatment in mice.
Topics: Animals; Antidepressive Agents; Apigenin; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corti | 2016 |
Chronic 5-HT4 receptor agonist treatment restores learning and memory deficits in a neuroendocrine mouse model of anxiety/depression.
Topics: Aniline Compounds; Animals; Antidepressive Agents; Anxiety; Association Learning; Corticosterone; De | 2016 |
Neonatal proinflammatory challenge in male Wistar rats: Effects on behavior, synaptic plasticity, and adrenocortical stress response.
Topics: Age Factors; Animals; Animals, Newborn; Anxiety; Conditioning, Psychological; Corticosterone; Depres | 2016 |
Apelin-13 exerts antidepressant-like and recognition memory improving activities in stressed rats.
Topics: Animals; Antidepressive Agents; Chromones; Corticosterone; Depression; Disease Models, Animal; Enzym | 2016 |
Icariin reverses corticosterone-induced depression-like behavior, decrease in hippocampal brain-derived neurotrophic factor (BDNF) and metabolic network disturbances revealed by NMR-based metabonomics in rats.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; | 2016 |
Social Isolation Stress Induces Anxious-Depressive-Like Behavior and Alterations of Neuroplasticity-Related Genes in Adult Male Mice.
Topics: Adrenal Glands; Animals; Anxiety; Brain-Derived Neurotrophic Factor; Corticosterone; Cytoskeletal Pr | 2016 |
Zinc and imipramine reverse the depression-like behavior in mice induced by chronic restraint stress.
Topics: Animals; Brain-Derived Neurotrophic Factor; Corticosterone; CREB-Binding Protein; Depression; Depres | 2016 |
Antidepressant-Like Effect of Ropren® in β-Amyloid-(25-35) Rat Model of Alzheimer's Disease with Altered Levels of Androgens.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Androgens; Animals; Antidepressive Agents; Corticosterone; | 2017 |
The role of medial prefrontal corticosterone and dopamine in the antidepressant-like effect of exercise.
Topics: Animals; Antidepressive Agents; Corticosterone; Depression; Depressive Disorder; Dopamine; Glucocort | 2016 |
Neonatal handling alters maternal emotional response to stress.
Topics: Adrenal Glands; Animals; Animals, Newborn; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cort | 2016 |
Disturbed diurnal rhythm of three classical phase markers in the chronic mild stress rat model of depression.
Topics: Anhedonia; Animals; Biomarkers; Body Temperature; Circadian Rhythm; Corticosterone; Depression; Eati | 2016 |
Chronic intermittent ethanol exposure during adolescence: Effects on stress-induced social alterations and social drinking in adulthood.
Topics: Aging; Alcohol Drinking; Animals; Anxiety; Binge Drinking; Central Nervous System Depressants; Corti | 2017 |
Antidepressant-like Effects of LPM580153, A Novel Potent Triple Reuptake Inhibitor.
Topics: Anhedonia; Animals; Antidepressive Agents; Biological Transport; Blotting, Western; Brain-Derived Ne | 2016 |
Antidepressant-like effects of water extract of Gastrodia elata Blume in rats exposed to unpredictable chronic mild stress via modulation of monoamine regulatory pathways.
Topics: Animals; Antidepressive Agents; Benzyl Alcohols; Brain; Corticosterone; Depression; Dopamine; Gastro | 2016 |
3,5,6,7,8,3',4'-Heptamethoxyflavone, a Citrus Flavonoid, Ameliorates Corticosterone-Induced Depression-like Behavior and Restores Brain-Derived Neurotrophic Factor Expression, Neurogenesis, and Neuroplasticity in the Hippocampus.
Topics: Animals; Behavior, Animal; Body Weight; Brain-Derived Neurotrophic Factor; Citrus; Corticosterone; D | 2016 |
Fourteen-day administration of corticosterone may induce detrusor overactivity symptoms.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Corticosterone; Depression; Disease | 2016 |
Loss of dopaminergic neurons occurs in the ventral tegmental area and hypothalamus of rats following chronic stress: Possible pathogenetic loci for depression involved in Parkinson's disease.
Topics: Animals; Corticosterone; Depression; Dopaminergic Neurons; Hypothalamus; Male; Microglia; Nerve Dege | 2016 |
Adjuvant indoleamine 2,3-dioxygenase enzyme inhibition for comprehensive management of epilepsy and comorbid depression.
Topics: Animals; Comorbidity; Corticosterone; Depression; Drug Interactions; Enzyme Inhibitors; Epilepsy; Hi | 2016 |
Disruption of the HPA-axis through corticosterone-release pellets induces robust depressive-like behavior and reduced BDNF levels in mice.
Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Dopamine; | 2016 |
Naringin and Sertraline Ameliorate Doxorubicin-Induced Behavioral Deficits Through Modulation of Serotonin Level and Mitochondrial Complexes Protection Pathway in Rat Hippocampus.
Topics: Animals; Behavior, Animal; Corticosterone; Depression; Doxorubicin; Flavanones; Hippocampus; Male; M | 2016 |
Antidepressant imipramine diminishes stress-induced inflammation in the periphery and central nervous system and related anxiety- and depressive- like behaviors.
Topics: Animals; Antidepressive Agents, Tricyclic; Anxiety; Behavior, Animal; Corticosterone; Depression; Im | 2016 |
Hypothalamic Proteomic Analysis Reveals Dysregulation of Glutamate Balance and Energy Metabolism in a Mouse Model of Chronic Mild Stress-Induced Depression.
Topics: Animals; Corticosterone; Depression; Depressive Disorder; Disease Models, Animal; Energy Metabolism; | 2016 |
Chronic activation of NPFFR2 stimulates the stress-related depressive behaviors through HPA axis modulation.
Topics: Animals; Antidepressive Agents; Anxiety; Anxiety Disorders; Chronic Disease; Corticosterone; Cortico | 2016 |
Adipogenesis and aldosterone: a study in lean tryptophan-depleted rats.
Topics: Adipogenesis; Aldosterone; Animals; Corticosterone; Depression; Female; Rats; Rats, Sprague-Dawley; | 2016 |
Simultaneous Changes in Sleep, qEEG, Physiology, Behaviour and Neurochemistry in Rats Exposed to Repeated Social Defeat Stress.
Topics: Animals; Behavior, Animal; Brain; Corticosterone; Depression; Disease Models, Animal; Dopamine; Elec | 2016 |
Elevated paternal glucocorticoid exposure alters the small noncoding RNA profile in sperm and modifies anxiety and depressive phenotypes in the offspring.
Topics: Animals; Anxiety; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Exons; Fear; Female | 2016 |
Mgat5 modulates the effect of early life stress on adult behavior and physical health in mice.
Topics: Animals; Body Weight; Bone Density; Brain; Corticosterone; Dendritic Spines; Depression; Female; Gen | 2016 |
Effects of environmental stress on the depression-like behaviors and the diurnal rhythm of corticosterone and melatonin in male rats.
Topics: Animals; Anxiety; Behavior, Animal; Circadian Rhythm; Corticosterone; Depression; Depressive Disorde | 2016 |
Depression-Like Adult Behaviors may be a Long-Term Result of Experimental Pneumococcal Meningitis in Wistar Rats Infants.
Topics: Animals; Behavior, Animal; Brain; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Dis | 2016 |
Schisandra chinensis produces the antidepressant-like effects in repeated corticosterone-induced mice via the BDNF/TrkB/CREB signaling pathway.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Corticosterone; Cyclic AMP Respon | 2016 |
Male-specific effects of lipopolysaccharide on glucocorticoid receptor nuclear translocation in the prefrontal cortex of depressive rats.
Topics: Animals; Behavior, Animal; Cell Nucleus; Corticosterone; Depression; Depressive Disorder, Major; Fem | 2016 |
Antidepressant treatment differentially affects the phenotype of high and low stress reactive mice.
Topics: Adaptation, Psychological; Animals; Antidepressive Agents; Corticosterone; Depression; Fluoxetine; H | 2016 |
Chinese herbal medicines promote hippocampal neuroproliferation, reduce stress hormone levels, inhibit apoptosis, and improve behavior in chronically stressed mice.
Topics: Animals; Apoptosis; Behavior, Animal; Cell Line; Cell Proliferation; Corticosterone; Depression; Dru | 2016 |
Repeated treatment with oxytocin promotes hippocampal cell proliferation, dendritic maturation and affects socio-emotional behavior.
Topics: Animals; Anxiety; Cell Proliferation; Corticosterone; Dendrites; Dentate Gyrus; Depression; Disease | 2016 |
Omega-3 polyunsaturated fatty acids critically regulate behaviour and gut microbiota development in adolescence and adulthood.
Topics: Aging; Animals; Behavior, Animal; Cognition; Corticosterone; Cytokines; Depression; Fatty Acids; Fat | 2017 |
Evaluation of the antidepressant-like effect of musk in an animal model of depression: how it works.
Topics: Administration, Inhalation; Animals; Antidepressive Agents; Behavior; Brain-Derived Neurotrophic Fac | 2017 |
miR-17-92 Cluster Regulates Adult Hippocampal Neurogenesis, Anxiety, and Depression.
Topics: Aging; Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Hippo | 2016 |
The antidepressant effect of musk in an animal model of depression: a histopathological study.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Caspase 3; Corticosterone; Depres | 2016 |
Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat.
Topics: Adult; Aged; Animals; C-Reactive Protein; Case-Control Studies; Corticosterone; Cytokines; Depressio | 2016 |
Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat.
Topics: Adult; Aged; Animals; C-Reactive Protein; Case-Control Studies; Corticosterone; Cytokines; Depressio | 2016 |
Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat.
Topics: Adult; Aged; Animals; C-Reactive Protein; Case-Control Studies; Corticosterone; Cytokines; Depressio | 2016 |
Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat.
Topics: Adult; Aged; Animals; C-Reactive Protein; Case-Control Studies; Corticosterone; Cytokines; Depressio | 2016 |
Baicalin promotes hippocampal neurogenesis via SGK1- and FKBP5-mediated glucocorticoid receptor phosphorylation in a neuroendocrine mouse model of anxiety/depression.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Anxiety; Behavior, Anima | 2016 |
Neuroprotective, Neurotrophic and Anti-oxidative Role of Bacopa monnieri on CUS Induced Model of Depression in Rat.
Topics: Animals; Antidepressive Agents; Antioxidants; Bacopa; Behavior, Animal; Corticosterone; Depression; | 2016 |
Bilobalide alleviates depression-like behavior and cognitive deficit induced by chronic unpredictable mild stress in mice.
Topics: Animals; Behavior, Animal; Cognition Disorders; Corticosterone; Cyclopentanes; Depression; Discrimin | 2016 |
Short- and long-term effects of stress during adolescence on emotionality and HPA function of animals exposed to alcohol prenatally.
Topics: Age Factors; Animals; Anxiety; Basolateral Nuclear Complex; Behavior, Animal; Central Nervous System | 2016 |
Postnatal light alters hypothalamic-pituitary-adrenal axis function and induces a depressive-like phenotype in adult mice.
Topics: Animals; Body Temperature; Circadian Rhythm; Corticosterone; Corticotropin-Releasing Hormone; Depres | 2016 |
Traditional herbal formula Sini Powder extract produces antidepressant-like effects through stress-related mechanisms in rats.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Corticosterone; Depression; Drugs, Chin | 2016 |
Early Life Stress Increases Metabolic Risk, HPA Axis Reactivity, and Depressive-Like Behavior When Combined with Postweaning Social Isolation in Rats.
Topics: Adaptation, Psychological; Animals; Behavior, Animal; Corticosterone; Depression; Female; Glucose; H | 2016 |
Antidepressant-like effects and cognitive enhancement of the total phenols extract of Hemerocallis citrina Baroni in chronic unpredictable mild stress rats and its related mechanism.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Biogenic Monoamines; Brain-Derived Neurotrophic Fa | 2016 |
Chronic corticosterone treatment enhances extinction-induced depression in aged rats.
Topics: Aging; Animals; Corticosterone; Cues; Depression; Extinction, Psychological; Humans; Hypothalamo-Hyp | 2016 |
Cipadesin A, a bioactive ingredient of Xylocarpus granatum, produces antidepressant-like effects in adult mice.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Corticosterone; Depression; Hindlimb Su | 2016 |
Selective CRF2 receptor agonists ameliorate the anxiety- and depression-like state developed during chronic nicotine treatment and consequent acute withdrawal in mice.
Topics: Animals; Anxiety; Corticosterone; Depression; Disease Models, Animal; Drug Evaluation, Preclinical; | 2016 |
Neuropsin Inactivation Has Protective Effects against Depressive-Like Behaviours and Memory Impairment Induced by Chronic Stress.
Topics: Animals; Corticosterone; Depression; Disease Models, Animal; Glutamic Acid; Hippocampus; Humans; Kal | 2016 |
Perinatal programming of depressive-like behavior by inflammation in adult offspring mice whose mothers were fed polluted eels: Gender selective effects.
Topics: Animals; Behavior, Animal; Biomarkers; Brain; Corticosterone; Depression; Depressive Disorder; Femal | 2017 |
Creatine Prevents Corticosterone-Induced Reduction in Hippocampal Proliferation and Differentiation: Possible Implication for Its Antidepressant Effect.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Cell Differentiation; Cell Proliferation; Corticos | 2017 |
Corticosteroids Mediate Heart Failure-Induced Depression through Reduced σ1-Receptor Expression.
Topics: Adenosine Triphosphate; Administration, Oral; Animals; Aorta; Behavior, Animal; Cardiomegaly; Cortic | 2016 |
Behavioural and neurochemical consequences of chronic gut microbiota depletion during adulthood in the rat.
Topics: Animals; Anti-Bacterial Agents; Anxiety; Brain; Brain-Derived Neurotrophic Factor; Cecum; Corticoste | 2016 |
Resveratrol Ameliorates the Depressive-Like Behaviors and Metabolic Abnormalities Induced by Chronic Corticosterone Injection.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Blood Glucose; Body Weight; Corticosterone; Depres | 2016 |
Attenuation of acute restraint stress-induced depressive like behavior and hippocampal alterations with protocatechuic acid treatment in mice.
Topics: Animals; Antioxidants; Anxiety; Atrophy; Corticosterone; Depression; Female; Hippocampus; Hydroxyben | 2017 |
Strain and sex based characterization of behavioral expressions in non-induced compulsive-like mice.
Topics: Analysis of Variance; Animals; Corticosterone; Depression; Disease Models, Animal; Enzyme-Linked Imm | 2017 |
M30 Antagonizes Indoleamine 2,3-Dioxygenase Activation and Neurodegeneration Induced by Corticosterone in the Hippocampus.
Topics: Animals; Corticosterone; Dendritic Spines; Depression; Enzyme Activation; Hippocampus; Hydroxyquinol | 2016 |
Molecular modifications by regulating cAMP signaling and oxidant-antioxidant defence mechanisms, produce antidepressant-like effect: A possible mechanism of etazolate aftermaths of impact accelerated traumatic brain injury in rat model.
Topics: Animals; Antidepressive Agents; Antioxidants; Behavior, Animal; Brain Injuries, Traumatic; Corticost | 2017 |
Antidepressant effect of recombinant NT4-NAP/AAV on social isolated mice through intranasal route.
Topics: Administration, Intranasal; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticoste | 2017 |
Blunted 5-HT
Topics: Animals; Antidepressive Agents; Body Temperature; Brain; Corticosterone; Depression; Female; GABA An | 2017 |
Alterations in splenic function and gene expression in mice with depressive-like behavior induced by exposure to corticosterone.
Topics: Animals; Behavior, Animal; Biomarkers; Cluster Analysis; Corticosterone; Depression; Disease Models, | 2017 |
A mixed glucocorticoid/mineralocorticoid receptor modulator dampens endocrine and hippocampal stress responsivity in male rats.
Topics: Amygdala; Animals; Corticosterone; Depression; Hippocampus; Hormones; Imipramine; Male; Motor Activi | 2017 |
Anhedonia but not passive floating is an indicator of depressive-like behavior in two chronic stress paradigms.
Topics: Animals; Brain; Corticosterone; Depression; Disease Models, Animal; Electroshock; Exploratory Behavi | 2016 |
Paternal environmental enrichment transgenerationally alters affective behavioral and neuroendocrine phenotypes.
Topics: Adrenocorticotropic Hormone; Animals; Behavior, Animal; Corticosterone; Depression; Environment; Epi | 2017 |
Neonatal blockade of GABA-A receptors alters behavioral and physiological phenotypes in adult mice.
Topics: Adaptation, Ocular; Age Factors; Animals; Animals, Newborn; Anxiety; Behavior, Animal; Bicuculline; | 2017 |
Dissecting stress with transcriptomics.
Topics: Anxiety; Corticosterone; Corticotropin-Releasing Hormone; Depression; Drug Design; Female; Gene Expr | 2017 |
Physical versus psychological social stress in male rats reveals distinct cardiovascular, inflammatory and behavioral consequences.
Topics: Anhedonia; Animals; Behavior, Animal; Blood Pressure; Cardiovascular Diseases; Chromatography, High | 2017 |
Targeting the Microbiota-Gut-Brain Axis: Prebiotics Have Anxiolytic and Antidepressant-like Effects and Reverse the Impact of Chronic Stress in Mice.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Brain; Corticosterone; Depression; Dis | 2017 |
Chronic unpredictable mild stress paradigm in male Wistar rats: effect on anxiety- and depressive-like behavior.
Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Male; Rats; | 2016 |
The protective effects of social bonding on behavioral and pituitary-adrenal axis reactivity to chronic mild stress in prairie voles.
Topics: Adrenocorticotropic Hormone; Animals; Arvicolinae; Behavior, Animal; Corticosterone; Depression; Fem | 2017 |
Susceptibility or resilience? Prenatal stress predisposes male rats to social subordination, but facilitates adaptation to subordinate status.
Topics: Adaptation, Psychological; Adrenal Glands; Animals; Behavior, Animal; Brain; Corticosterone; Depress | 2017 |
Chronic corticosterone administration effects on behavioral emotionality in female c57bl6 mice.
Topics: Animals; Behavior, Animal; Cell Proliferation; Corticosterone; Depression; Depressive Disorder, Majo | 2017 |
Agmatine attenuates chronic unpredictable mild stress-induced anxiety, depression-like behaviours and cognitive impairment by modulating nitrergic signalling pathway.
Topics: Agmatine; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Animal; Chronic Di | 2017 |
Effects of Marapuama in the chronic mild stress model: further indication of antidepressant properties.
Topics: Animals; Antidepressive Agents; Corticosterone; Depression; Disease Models, Animal; Dose-Response Re | 2008 |
Stress, geomagnetic disturbance, infradian and circadian sampling for circulating corticosterone and models of human depression?
Topics: Animals; Body Weight; Chronobiology Disorders; Circadian Rhythm; Corticosterone; Depression; Dietary | 2008 |
Moderate perinatal arsenic exposure alters neuroendocrine markers associated with depression and increases depressive-like behaviors in adult mouse offspring.
Topics: Analysis of Variance; Animals; Animals, Newborn; Arsenic; Behavior, Animal; Corticosterone; Depressi | 2008 |
Hindlimb unloading elicits anhedonia and sympathovagal imbalance.
Topics: Adrenergic beta-Antagonists; Animals; Baroreflex; Behavior, Animal; Blood Pressure; Cardiovascular D | 2008 |
Decreased brain docosahexaenoic acid content produces neurobiological effects associated with depression: Interactions with reproductive status in female rats.
Topics: Adaptation, Physiological; alpha-Linolenic Acid; Analysis of Variance; Animals; Brain; Brain Chemist | 2008 |
Aging increases the susceptibility to develop anhedonia in male rats.
Topics: Aging; Analysis of Variance; Animals; Chronic Disease; Conditioning, Operant; Corticosterone; Depres | 2008 |
Remodeling of hippocampal spine synapses in the rat learned helplessness model of depression.
Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents, Tricyclic; Biomarkers, Pharmacological; Co | 2009 |
Chronically restricted sleep leads to depression-like changes in neurotransmitter receptor sensitivity and neuroendocrine stress reactivity in rats.
Topics: Animals; Conditioning, Psychological; Corticosterone; Corticotropin-Releasing Hormone; Depression; F | 2008 |
Behavioral despair and home-cage activity in mice with chronically elevated baseline corticosterone concentrations.
Topics: Animals; Behavior; Behavior, Animal; Corticosterone; Depression; Female; Genetic Predisposition to D | 2009 |
Central nervous action of interleukin-1 mediates activation of limbic structures and behavioural depression in response to peripheral administration of bacterial lipopolysaccharide.
Topics: Animals; Behavior, Animal; Body Temperature; Body Weight; Brain; Corticosterone; Depression; Fever; | 2008 |
Corticosterone regulates pERK1/2 map kinase in a chronic depression model.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Conditioning, O | 2008 |
Progesterone modulation of alpha5 nAChR subunits influences anxiety-related behavior during estrus cycle.
Topics: Animals; Anxiety; Behavior, Animal; Cells, Cultured; Corticosterone; Corticotropin-Releasing Hormone | 2009 |
Antidepressant-like effects of melatonin in the mouse chronic mild stress model.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Chronic Disease; Circadian Rhythm; Corticosterone; | 2009 |
Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy.
Topics: Animals; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Electrodes, Implanted | 2009 |
Maternal postpartum learned helplessness (LH) affects maternal care by dams and responses to the LH test in adolescent offspring.
Topics: Animals; Anxiety; Body Weight; Brain-Derived Neurotrophic Factor; Breast Feeding; Corticosterone; De | 2009 |
Long-term anxiolytic and antidepressant-like behavioural effects of tiagabine, a selective GABA transporter-1 (GAT-1) inhibitor, coincide with a decrease in HPA system activity in C57BL/6 mice.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Arginine Vasopressin; Corticosterone; | 2010 |
Delayed stress-induced differences in locomotor and depression-related behaviour in female neuropeptide-Y Y1 receptor knockout mice.
Topics: Analgesia; Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Female; Mice; Mice, 129 S | 2010 |
Gender-specific impact of brain-derived neurotrophic factor signaling on stress-induced depression-like behavior.
Topics: Analysis of Variance; Animals; Body Weight; Brain-Derived Neurotrophic Factor; Corticosterone; Depre | 2009 |
Repeated exposure to corticosterone increases depression-like behavior in two different versions of the forced swim test without altering nonspecific locomotor activity or muscle strength.
Topics: Animals; Behavior, Animal; Body Weight; Corticosterone; Depression; Hand Strength; Male; Motor Activ | 2009 |
Suppressive effect of quercetin on acute stress-induced hypothalamic-pituitary-adrenal axis response in Wistar rats.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Corticosterone; Corticotropin-Releasing | 2010 |
Effects of acupuncture on chronic corticosterone-induced depression-like behavior and expression of neuropeptide Y in the rats.
Topics: Acupuncture Therapy; Animals; Anxiety; Behavior, Animal; Chronic Disease; Corticosterone; Depression | 2009 |
Preventive action of Kai Xin San aqueous extract on depressive-like symptoms and cognition deficit induced by chronic mild stress.
Topics: Acetylcholinesterase; Acorus; Adrenocorticotropic Hormone; Animals; Chronic Disease; Cognition Disor | 2009 |
Depression-like behavior in the forced swimming test in PACAP-deficient mice: amelioration by the atypical antipsychotic risperidone.
Topics: Animals; Antipsychotic Agents; Body Temperature; Circadian Rhythm; Corticosterone; Depression; Male; | 2009 |
Behavior in the forced swim test and neurochemical changes in the hippocampus in young rats after 2-week zinc deprivation.
Topics: Adenosine Triphosphate; Amino Acids; Animals; Antimetabolites; Behavior, Animal; Blood Glucose; Calc | 2009 |
Dissecting the pathophysiology of depression with a Swiss army knife.
Topics: Animals; Corticosterone; Depression; Disease Models, Animal; Fluoxetine; Hippocampus; Humans; Neurog | 2009 |
Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Anxiety; Arrestins; beta-Ar | 2009 |
Sini tang prevents depression-like behavior in rats exposed to chronic unpredictable stress.
Topics: Animals; Base Sequence; Behavior, Animal; Corticosterone; Corticotropin-Releasing Hormone; Depressio | 2009 |
Influence of light at night on murine anxiety- and depressive-like responses.
Topics: Animals; Anxiety; Corticosterone; Depression; Dietary Sucrose; Drinking Behavior; Light; Lighting; L | 2009 |
Trilostane exerts antidepressive effects among wild-type, but not estrogen receptor [beta] knockout mice.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Corticosterone; Depression; Dihydrotestosteron | 2009 |
Anhedonia and altered cardiac atrial natriuretic peptide following chronic stressor and endotoxin treatment in mice.
Topics: Animals; Atrial Natriuretic Factor; Corticosterone; Depression; Dietary Sucrose; Eating; Endotoxins; | 2010 |
Short- and long-term influences of hypoxia during early postnatal period of development on behavioral and hormonal responses in rats.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Corticosterone; Depression; Hypoxia; Pain; Pain | 2009 |
Depressive-like parameters in sepsis survivor rats.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Analysis of Variance; Animals; Antidepressive Agents, T | 2010 |
Stress and IL-1beta contribute to the development of depressive-like behavior following peripheral nerve injury.
Topics: Analysis of Variance; Animals; Corticosterone; Cytokines; Depression; Disease Models, Animal; Explor | 2010 |
The lonely mouse: verification of a separation-induced model of depression in female mice.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Conditioning, Classi | 2010 |
Ferulic acid induces neural progenitor cell proliferation in vitro and in vivo.
Topics: Aging; Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; Central Nervous System Ag | 2010 |
High susceptibility to chronic social stress is associated with a depression-like phenotype.
Topics: Animals; Anxiety; Behavior, Animal; Body Weight; Brain; Corticosterone; Corticotropin-Releasing Horm | 2010 |
Stress-related endocrinological and psychopathological effects of short- and long-term 50Hz electromagnetic field exposure in rats.
Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Blood Glucose; Body Weight; Chronic Disease; Corticos | 2010 |
Dynamic DNA methylation programs persistent adverse effects of early-life stress.
Topics: Animals; Animals, Newborn; Arginine Vasopressin; Behavior, Animal; Corticosterone; Depression; DNA M | 2009 |
Anti-depressant and anxiolytic like behaviors in PKCI/HINT1 knockout mice associated with elevated plasma corticosterone level.
Topics: Analysis of Variance; Animals; Anxiety; Avoidance Learning; Behavior, Animal; Corticosterone; Cues; | 2009 |
Physical stress differs from psychosocial stress in the pattern and time-course of behavioral responses, serum corticosterone and expression of plasticity-related genes in the rat.
Topics: Amygdala; Animals; Anxiety; Behavior, Animal; Corticosterone; Cyclic AMP Response Element-Binding Pr | 2009 |
Circadian phase and sex effects on depressive/anxiety-like behaviors and HPA axis responses to acute stress.
Topics: Animals; Anxiety; Circadian Rhythm; Corticosterone; Depression; Disease Models, Animal; Female; Hypo | 2010 |
Palatable cafeteria diet ameliorates anxiety and depression-like symptoms following an adverse early environment.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Animals; Anxiety; Corticosterone; Corticotropin-Releasi | 2010 |
Shaping brain development: mouse communal nesting blunts adult neuroendocrine and behavioral response to social stress and modifies chronic antidepressant treatment outcome.
Topics: Animals; Behavior, Animal; Brain; Corticosterone; Depression; Drug Administration Schedule; Female; | 2010 |
Maternal and genetic factors in stress-resilient and -vulnerable rats: a cross-fostering study.
Topics: Adrenal Glands; Aging; Animals; Anxiety; Body Weight; Corticosterone; Depression; Feeding Behavior; | 2010 |
Interferon-gamma deficiency modifies the effects of a chronic stressor in mice: Implications for psychological pathology.
Topics: Animals; Anxiety; Behavior, Animal; Biogenic Monoamines; Brain; Chromatography, High Pressure Liquid | 2010 |
Ambiguous-cue interpretation is biased under stress- and depression-like states in rats.
Topics: Adrenergic Uptake Inhibitors; Amygdala; Analysis of Variance; Animals; Behavior, Animal; Bias; Condi | 2010 |
F15599, a highly selective post-synaptic 5-HT(1A) receptor agonist: in-vivo profile in behavioural models of antidepressant and serotonergic activity.
Topics: Aminopyridines; Animals; Antidepressive Agents; Corticosterone; Depression; Hypothermia; Male; Model | 2010 |
The 5-HT(7) receptor as a mediator and modulator of antidepressant-like behavior.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Aripiprazole; Citalopram; Corticosterone; Depr | 2010 |
Mifepristone decreases depression-like behavior and modulates neuroendocrine and central hypothalamic-pituitary-adrenocortical axis responsiveness to stress.
Topics: Adrenocorticotropic Hormone; Amygdala; Animals; Corticosterone; Depression; Hippocampus; Hypothalamo | 2010 |
Macrophage migration inhibitory factor is critically involved in basal and fluoxetine-stimulated adult hippocampal cell proliferation and in anxiety, depression, and memory-related behaviors.
Topics: Acoustic Stimulation; Animals; Antidepressive Agents, Second-Generation; Anxiety; Bromodeoxyuridine; | 2011 |
Interactions between age, stress and insulin on cognition: implications for Alzheimer's disease.
Topics: Aging; Amyloid beta-Peptides; Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Cognitio | 2010 |
Low dose dexamethasone reverses depressive-like parameters and memory impairment in rats submitted to sepsis.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Anti-Inflammatory Agents; Avoidance Learning; | 2010 |
Circadian activity of corticosterone in an animal model of depression: response to muscarinic cholinergic stimulation.
Topics: Animals; Animals, Newborn; Antidepressive Agents, Second-Generation; Behavior, Animal; Cholinergic A | 2010 |
The suitability of 129SvEv mice for studying depressive-like behaviour: both males and females develop learned helplessness.
Topics: Analysis of Variance; Animals; Behavior, Animal; Behavioral Research; Corticosterone; Depression; Di | 2010 |
"Green odor" inhalation by stressed rat dams reduces behavioral and neuroendocrine signs of prenatal stress in the offspring.
Topics: Administration, Inhalation; Adrenal Glands; Adrenocorticotropic Hormone; Aldehydes; Animals; Body We | 2010 |
Evaluating the interaction between early postnatal inflammation and maternal care in the programming of adult anxiety and depression-related behaviors.
Topics: Aging; Animals; Animals, Newborn; Anxiety; Corticosterone; Depression; Female; Inflammation; Lipopol | 2010 |
Resistance to the development of stress-induced behavioral despair in the forced swim test associated with elevated hippocampal Bcl-xl expression.
Topics: Adrenocorticotropic Hormone; Animals; bcl-2-Associated X Protein; bcl-X Protein; Brain-Derived Neuro | 2010 |
Exercise effects on motor and affective behavior and catecholamine neurochemistry in the MPTP-lesioned mouse.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anxiety; Behavior, Animal; Brain; Corticoster | 2010 |
Antidepressant effects of the extract YZ-50 from Polygala tenuifolia in chronic mild stress treated rats and its possible mechanisms.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Cort | 2010 |
Chronic corticosterone during pregnancy and postpartum affects maternal care, cell proliferation and depressive-like behavior in the dam.
Topics: Algorithms; Animals; Behavior, Animal; Brain; Cell Proliferation; Corticosterone; Depression; Depres | 2010 |
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.
Topics: Animals; Antidepressive Agents; Arginine Vasopressin; Behavior, Animal; Bifidobacterium; Biogenic Mo | 2010 |
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.
Topics: Animals; Antidepressive Agents; Arginine Vasopressin; Behavior, Animal; Bifidobacterium; Biogenic Mo | 2010 |
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.
Topics: Animals; Antidepressive Agents; Arginine Vasopressin; Behavior, Animal; Bifidobacterium; Biogenic Mo | 2010 |
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.
Topics: Animals; Antidepressive Agents; Arginine Vasopressin; Behavior, Animal; Bifidobacterium; Biogenic Mo | 2010 |
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.
Topics: Animals; Antidepressive Agents; Arginine Vasopressin; Behavior, Animal; Bifidobacterium; Biogenic Mo | 2010 |
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.
Topics: Animals; Antidepressive Agents; Arginine Vasopressin; Behavior, Animal; Bifidobacterium; Biogenic Mo | 2010 |
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.
Topics: Animals; Antidepressive Agents; Arginine Vasopressin; Behavior, Animal; Bifidobacterium; Biogenic Mo | 2010 |
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.
Topics: Animals; Antidepressive Agents; Arginine Vasopressin; Behavior, Animal; Bifidobacterium; Biogenic Mo | 2010 |
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.
Topics: Animals; Antidepressive Agents; Arginine Vasopressin; Behavior, Animal; Bifidobacterium; Biogenic Mo | 2010 |
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.
Topics: Animals; Antidepressive Agents; Arginine Vasopressin; Behavior, Animal; Bifidobacterium; Biogenic Mo | 2010 |
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.
Topics: Animals; Antidepressive Agents; Arginine Vasopressin; Behavior, Animal; Bifidobacterium; Biogenic Mo | 2010 |
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.
Topics: Animals; Antidepressive Agents; Arginine Vasopressin; Behavior, Animal; Bifidobacterium; Biogenic Mo | 2010 |
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.
Topics: Animals; Antidepressive Agents; Arginine Vasopressin; Behavior, Animal; Bifidobacterium; Biogenic Mo | 2010 |
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.
Topics: Animals; Antidepressive Agents; Arginine Vasopressin; Behavior, Animal; Bifidobacterium; Biogenic Mo | 2010 |
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.
Topics: Animals; Antidepressive Agents; Arginine Vasopressin; Behavior, Animal; Bifidobacterium; Biogenic Mo | 2010 |
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression.
Topics: Animals; Antidepressive Agents; Arginine Vasopressin; Behavior, Animal; Bifidobacterium; Biogenic Mo | 2010 |
Evidence of female-specific glial deficits in the hippocampus in a mouse model of prenatal stress.
Topics: Animals; Anxiety; Behavior, Animal; Cognition; Corticosterone; Depression; Disease Models, Animal; F | 2011 |
Comparison of the antidepressant sertraline on differential depression-like behaviors elicited by restraint stress and repeated corticosterone administration.
Topics: Adrenal Glands; Animals; Antidepressive Agents, Second-Generation; Anxiety; Avoidance Learning; Cond | 2010 |
Reelin as a putative vulnerability factor for depression: examining the depressogenic effects of repeated corticosterone in heterozygous reeler mice.
Topics: Animals; Anti-Inflammatory Agents; Behavior, Animal; Brain; Cell Adhesion Molecules, Neuronal; Corti | 2011 |
Antidepressant-like effect of mitragynine isolated from Mitragyna speciosa Korth in mice model of depression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal | 2011 |
Lack of vasopressin does not prevent the behavioural and endocrine changes induced by chronic unpredictable stress.
Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Behavior, Animal; Body Weight; Corticosterone; Depres | 2011 |
Vulnerability to chronic subordination stress-induced depression-like disorders in adult 129SvEv male mice.
Topics: Aggression; Animals; Anxiety; Chronic Disease; Corticosterone; Depression; Disease Models, Animal; D | 2011 |
Chronic corticosterone administration from adolescence through early adulthood attenuates depression-like behaviors in mice.
Topics: Aging; Animals; Blotting, Western; Cell Proliferation; Corticosterone; Depression; Hippocampus; Hypo | 2011 |
Changes in adaptability following perinatal morphine exposure in juvenile and adult rats.
Topics: Adaptation, Psychological; Adrenocorticotropic Hormone; Analgesics, Opioid; Animals; Anxiety; Behavi | 2011 |
Protective effects of flavonoid extract from Apocynum venetum leaves against corticosterone-induced neurotoxicity in PC12 cells.
Topics: Animals; Apocynum; Calcium; Corticosterone; Depression; Disease Models, Animal; Flavonoids; L-Lactat | 2011 |
Chronic ω-3 fatty acids supplementation promotes beneficial effects on anxiety, cognitive and depressive-like behaviors in rats subjected to a restraint stress protocol.
Topics: Affect; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Animal; Cognition; C | 2011 |
Phenotypic characterization of a genetically diverse panel of mice for behavioral despair and anxiety.
Topics: Animals; Anxiety; Behavior, Animal; Brain; Brain Mapping; Corticosterone; Depression; Disease Models | 2010 |
Early and delayed effects of hypoxia during the infantile period on behavioral and hormonal reactions of rats.
Topics: Aging; Animals; Behavior, Animal; Corticosterone; Depression; Hypothalamo-Hypophyseal System; Hypoxi | 2010 |
A role for glucocorticoid-signaling in depression-like behavior of gastrin-releasing peptide receptor knock-out mice.
Topics: Amygdala; Animals; Behavior, Animal; Corticosterone; Depression; Dexamethasone; Disease Models, Anim | 2011 |
Icariin attenuates social defeat-induced down-regulation of glucocorticoid receptor in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal | 2011 |
Hypericum perforatum treatment: effect on behaviour and neurogenesis in a chronic stress model in mice.
Topics: Animals; Anxiety; Behavior, Animal; Cell Proliferation; Corticosterone; Dendrites; Depression; Disea | 2011 |
Curcumin reverses corticosterone-induced depressive-like behavior and decrease in brain BDNF levels in rats.
Topics: Animals; Antidepressive Agents; Brain; Brain-Derived Neurotrophic Factor; Corticosterone; Curcumin; | 2011 |
Effect of fish oil and coconut fat supplementation on depressive-type behavior and corticosterone levels of prenatally stressed male rats.
Topics: Animals; Biomarkers; Cocos; Corticosterone; Depression; Dietary Fats; Female; Fish Oils; Male; Pregn | 2011 |
Stress and the pregnant female: Impact on hippocampal cell proliferation, but not affective-like behaviors.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Cell Proliferation; Corticosterone; Depres | 2011 |
Cognitive and locomotor/exploratory behavior after chronic exercise in the olfactory bulbectomy animal model of depression.
Topics: Animals; Body Weight; Cognition; Conditioning, Psychological; Corticosterone; Depression; Disease Mo | 2011 |
Low dietary sodium is anxiogenic in rats.
Topics: Animals; Anxiety; Body Weight; Corticosterone; Depression; Disease Models, Animal; Food Preferences; | 2011 |
Altered aortic vascular reactivity in the unpredictable chronic mild stress model of depression in mice: UCMS causes relaxation impairment to ACh.
Topics: Acetylcholine; Animals; Aorta; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; | 2011 |
Do stress hormones connect environmental effects with behavior in the forced swim test?
Topics: Adaptation, Psychological; Adrenocorticotropic Hormone; Animals; Behavior, Animal; Body Temperature; | 2011 |
Dietary arginine depletion reduces depressive-like responses in male, but not female, mice.
Topics: Aggression; Animals; Anxiety; Arginine; Body Weight; Corticosterone; Depression; Disease Models, Ani | 2011 |
Antidepressants recruit new neurons to improve stress response regulation.
Topics: Animals; Antidepressive Agents; Cell Count; Corticosterone; Depression; Dexamethasone; Disease Model | 2011 |
Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice.
Topics: Animals; Behavior, Animal; Biomarkers; Corticosterone; Depression; Disease Models, Animal; Extracell | 2012 |
Electromagnetic field effect or simply stress? Effects of UMTS exposure on hippocampal longterm plasticity in the context of procedure related hormone release.
Topics: Adrenocorticotropic Hormone; Animals; Corticosterone; Depression; Electromagnetic Fields; Electrophy | 2011 |
Effects of octreotide in chronically mild stressed rats: possible role of immune and oxidative stress pathways.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Antineoplastic Agents, Hormonal; Antiox | 2011 |
Behavioural and neurochemical evaluation of Perment an herbal formulation in chronic unpredictable mild stress induced depressive model.
Topics: Animals; Behavior, Animal; Chronic Disease; Corticosterone; Depression; Disease Models, Animal; Expl | 2011 |
Chronic juvenile stress produces corticolimbic dendritic architectural remodeling and modulates emotional behavior in male and female rats.
Topics: Adaptation, Psychological; Amygdala; Anhedonia; Animals; Chronic Disease; Corticosterone; Dendrites; | 2012 |
Prolonged depression-like behavior caused by immune challenge: influence of mouse strain and social environment.
Topics: Animals; Behavior, Animal; Body Weight; Corticosterone; Depression; Female; Food Preferences; Housin | 2011 |
Paternal transmission of stress-induced pathologies.
Topics: Animals; Anxiety; Corticosterone; Depression; Disease Models, Animal; Father-Child Relations; Father | 2011 |
Association between Na⁺,K⁺-ATPase activity and the vulnerability/resilience to mood disorders induced by early life experience.
Topics: Adaptation, Psychological; Amygdala; Animals; Animals, Newborn; Blood Glucose; Corticosterone; Depre | 2011 |
High-fat diet selectively protects against the effects of chronic social stress in the mouse.
Topics: Animals; Anxiety; Corticosterone; Depression; Diet, High-Fat; Female; Insulin; Leptin; Male; Mice; M | 2011 |
Organic cation transporter 2 controls brain norepinephrine and serotonin clearance and antidepressant response.
Topics: Action Potentials; Animals; Antidepressive Agents, Second-Generation; Anxiety; Brain; Corticosterone | 2012 |
Site-specific genetic manipulation of amygdala corticotropin-releasing factor reveals its imperative role in mediating behavioral response to challenge.
Topics: Amygdala; Animals; Anxiety; Behavior, Animal; Corticosterone; Corticotropin-Releasing Hormone; Depre | 2012 |
Adult hippocampal neurogenesis buffers stress responses and depressive behaviour.
Topics: Animals; Behavior, Animal; Corticosterone; Dentate Gyrus; Depression; Dexamethasone; Glucocorticoids | 2011 |
Are different biological mechanisms involved in the transmission of maternal versus paternal stress-induced vulnerability to offspring?
Topics: Animals; Anxiety; Corticosterone; Depression; Disease Models, Animal; Father-Child Relations; Father | 2011 |
Differential effects of prenatal stress in 5-Htt deficient mice: towards molecular mechanisms of gene × environment interactions.
Topics: Analysis of Variance; Animals; Animals, Newborn; Anxiety; Cognition; Corticosterone; Depression; Fem | 2011 |
Gestational and postpartum corticosterone exposure to the dam affects behavioral and endocrine outcome of the offspring in a sexually-dimorphic manner.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Cell Proliferation; | 2012 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
Topics: Amplified Fragment Length Polymorphism Analysis; Animals; Anxiety; Brain; Corticosterone; Depression | 2011 |
Luteolin shows an antidepressant-like effect via suppressing endoplasmic reticulum stress.
Topics: Animals; Antidepressive Agents; Blotting, Western; Caspase 3; Cell Line, Tumor; Corticosterone; Depr | 2011 |
Behavioral sexual dimorphism in models of anxiety and depression due to changes in HPA axis activity.
Topics: Adrenalectomy; Analysis of Variance; Animals; Anxiety; Corticosterone; Dark Adaptation; Depression; | 2012 |
Maternal infection during late pregnancy increases anxiety- and depression-like behaviors with increasing age in male offspring.
Topics: Age Factors; Analysis of Variance; Animals; Anxiety; Corticosterone; Cytokines; Depression; Dose-Res | 2012 |
Permanent relief from intermittent cold stress-induced fibromyalgia-like abnormal pain by repeated intrathecal administration of antidepressants.
Topics: Analgesics; Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Body Weight; Cold Temperature | 2011 |
A single subanesthetic dose of ketamine relieves depression-like behaviors induced by neuropathic pain in rats.
Topics: Anesthetics, Dissociative; Animals; Antidepressive Agents; Behavior, Animal; Cold Temperature; Corti | 2011 |
Depressive phenotypes evoked by experimental diabetes are reversed by insulin.
Topics: Analysis of Variance; Animals; Blood Glucose; Brain; Brain-Derived Neurotrophic Factor; Bromodeoxyur | 2012 |
Green tea polyphenols produce antidepressant-like effects in adult mice.
Topics: Administration, Oral; Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Camellia sinensis | 2012 |
Social deprivation stress is a triggering factor for the emergence of anxiety- and depression-like behaviours and leads to reduced brain BDNF levels in C57BL/6J mice.
Topics: Adrenal Glands; Anhedonia; Animals; Anxiety; Behavior, Animal; Body Weight; Brain Chemistry; Brain-D | 2012 |
Exposure to enriched environment restores the mRNA expression of mineralocorticoid and glucocorticoid receptors in the hippocampus and ameliorates depressive-like symptoms in chronically stressed rats.
Topics: Animals; Body Weight; Corticosterone; Depression; Disease Models, Animal; Environment; Exploratory B | 2011 |
Functional status of somatodendritic serotonin 1A autoreceptor after long-term treatment with fluoxetine in a mouse model of anxiety/depression based on repeated corticosterone administration.
Topics: Animals; Anxiety; Autoreceptors; Corticosterone; Depression; Drug Resistance; Drug Therapy, Combinat | 2012 |
Cysteamine attenuates the decreases in TrkB protein levels and the anxiety/depression-like behaviors in mice induced by corticosterone treatment.
Topics: Animals; Anxiety; Corticosterone; Cysteamine; Depression; Mice; Mice, Knockout; Receptor, trkB | 2011 |
Origin and consequences of brain Toll-like receptor 4 pathway stimulation in an experimental model of depression.
Topics: Animals; Anti-Bacterial Agents; Behavior, Animal; Brain; Corticosterone; Depression; Encephalitis; I | 2011 |
Sub-chronic dietary tryptophan depletion--an animal model of depression with improved face and good construct validity.
Topics: Aldosterone; Analysis of Variance; Animals; Body Weight; Brain; Calcium-Binding Proteins; Catecholam | 2012 |
Exposure to repeated maternal aggression induces depressive-like behavior and increases startle in adult female rats.
Topics: Acoustic Stimulation; Aggression; Analysis of Variance; Animals; Corticosterone; Depression; Estrous | 2012 |
Lack of elevations in glucocorticoids correlates with dysphoria-like behavior after repeated social defeat.
Topics: Adrenal Glands; Anhedonia; Animals; Anxiety; CA2 Region, Hippocampal; Corticosterone; Depression; Di | 2012 |
Peony glycosides reverse the effects of corticosterone on behavior and brain BDNF expression in rats.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Brain; Br | 2012 |
Juvenile social subjugation induces a sex-specific pattern of anxiety and depression-like behaviors in adult rats.
Topics: Adrenal Glands; Aggression; Animals; Anxiety; Corticosterone; Depression; Female; Male; Organ Size; | 2012 |
Reorganization of synaptic inputs to the hypothalamic paraventricular nucleus during chronic psychogenic stress in rats.
Topics: Animals; Behavioral Symptoms; Chronic Disease; Corticosterone; Corticotropin-Releasing Hormone; Depr | 2012 |
Ascorbic acid treatment, similarly to fluoxetine, reverses depressive-like behavior and brain oxidative damage induced by chronic unpredictable stress.
Topics: Animals; Antidepressive Agents; Antioxidants; Ascorbic Acid; Catalase; Cerebral Cortex; Corticostero | 2012 |
Beneficial effects of benzodiazepine diazepam on chronic stress-induced impairment of hippocampal structural plasticity and depression-like behavior in mice.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Brain-Derived Neurotrophic Factor; Corticosteron | 2012 |
Protective effects of piperine against corticosterone-induced neurotoxicity in PC12 cells.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Antidepressive Agents; Benzodioxoles; Corticosterone; | 2012 |
Deletion of forebrain glucocorticoid receptors impairs neuroendocrine stress responses and induces depression-like behavior in males but not females.
Topics: Animals; Behavior, Animal; Choice Behavior; Corticosterone; Depression; Female; Hypothalamo-Hypophys | 2012 |
Circadian activity of the hypothalamic-pituitary-adrenal axis is differentially affected in the rat chronic mild stress model of depression.
Topics: Animals; Circadian Rhythm; Corticosterone; Depression; Dexamethasone; Feces; Hypothalamo-Hypophyseal | 2012 |
Corticosterone reduces brain mitochondrial function and expression of mitofusin, BDNF in depression-like rodents regardless of exercise preconditioning.
Topics: Animals; Behavior, Animal; Brain; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Dis | 2012 |
Long lasting effects of early-life stress on glutamatergic/GABAergic circuitry in the rat hippocampus.
Topics: Age Factors; Animals; Antidepressive Agents, Second-Generation; Corticosterone; Cyclohexanols; Depre | 2012 |
Prenatal stress effects on emotion regulation differ by genotype and sex in prepubertal rats.
Topics: Animals; Corticosterone; Depression; Emotions; Female; Genotype; Male; Pregnancy; Prenatal Exposure | 2013 |
Behavioral training and predisposed coping strategies interact to influence resilience in male Long-Evans rats: implications for depression.
Topics: Adaptation, Psychological; Animals; Anxiety; Behavior, Animal; Brain; Brain Chemistry; Corticosteron | 2012 |
Antidepressant-like effects of ginsenoside Rg1 are due to activation of the BDNF signalling pathway and neurogenesis in the hippocampus.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; | 2012 |
Intermittent physical stress during early- and mid-adolescence differentially alters rats' anxiety- and depression-like behaviors in adulthood.
Topics: Age Factors; Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Exploratory Behavior; F | 2012 |
[Prenatal stressed female rats develop stable anxious and depressive state in experimental model of post-traumatic stress disorder].
Topics: Animals; Anxiety; Corticosterone; Depression; Disease Models, Animal; Female; Humans; Hydrocortisone | 2011 |
Chronic mild stress-induced depression-like symptoms in rats and abnormalities in catecholamine uptake in small arteries.
Topics: Analysis of Variance; Anhedonia; Animals; Arteries; Behavior, Animal; Blood Pressure; Catecholamines | 2012 |
Forebrain glutamatergic neurons mediate leptin action on depression-like behaviors and synaptic depression.
Topics: Animals; Arousal; Cerebral Cortex; Corticosterone; Depression; Dominance-Subordination; Exploratory | 2012 |
Hormonal and behavioural abnormalities induced by stress in utero: an animal model for depression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Circadian Rhythm; Corticosterone; Depression; Dise | 2001 |
Variant brain-derived neurotrophic factor Val66Met polymorphism alters vulnerability to stress and response to antidepressants.
Topics: Adrenocorticotropic Hormone; Analysis of Variance; Animals; Antidepressive Agents; Brain; Brain-Deri | 2012 |
Bupleurum falcatum prevents depression and anxiety-like behaviors in rats exposed to repeated restraint stress.
Topics: Animals; Antidepressive Agents; Anxiety; Brain; Bupleurum; Corticosterone; Depression; Depressive Di | 2012 |
Antidepressant-like activity of gallic acid in mice subjected to unpredictable chronic mild stress.
Topics: Animals; Antidepressive Agents; Antioxidants; Brain; Catalase; Corticosterone; Depression; Fluoxetin | 2013 |
Exofocal dopaminergic degeneration as antidepressant target in mouse model of poststroke depression.
Topics: Animals; Brain-Derived Neurotrophic Factor; Citalopram; Corticosterone; Depression; Disease Models, | 2012 |
Diet-induced obesity promotes depressive-like behaviour that is associated with neural adaptations in brain reward circuitry.
Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Diet, High-Fat; Disease Models, Anim | 2013 |
Urinary biopyrrins: potential biomarker for monitoring of the response to treatment with anxiolytics.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Bilirubin; Biomarkers; Corticosterone; Depression; Enzyme- | 2012 |
Antinociceptive effects of fluoxetine in a mouse model of anxiety/depression.
Topics: Animals; Antidepressive Agents, Second-Generation; Anxiety; Chronic Pain; Cold Temperature; Corticos | 2012 |
Zinc signaling in the hippocampus and its relation to pathogenesis of depression.
Topics: Animals; Corticosterone; Depression; Glucocorticoids; Hippocampus; Male; Rats; Stress, Physiological | 2012 |
Female early adult depression results in detrimental impacts on the behavioral performance and brain development in offspring.
Topics: Age Factors; Animals; Animals, Newborn; Astrocytes; Behavior, Animal; Body Weight; Brain; Bromodeoxy | 2012 |
NPY intraperitoneal injections produce antidepressant-like effects and downregulate BDNF in the rat hypothalamus.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Body Weight; Brain-Derived Neurotrophic Factor | 2012 |
Different emotional disturbances in two experimental models of temporal lobe epilepsy in rats.
Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Emotions; Ep | 2012 |
Post-training reward partially restores chronic stress induced effects in mice.
Topics: Animals; Corticosterone; Depression; Male; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Rats; Re | 2012 |
Chronic exposure to an extremely low-frequency magnetic field induces depression-like behavior and corticosterone secretion without enhancement of the hypothalamic-pituitary-adrenal axis in mice.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Behavior, Animal; Body Size; Corticosterone; D | 2013 |
Adiponectin is critical in determining susceptibility to depressive behaviors and has antidepressant-like activity.
Topics: Absorptiometry, Photon; Adiponectin; Anhedonia; Animals; Antibodies, Monoclonal; Blood Glucose; Cort | 2012 |
Neurobiological sequelae of witnessing stressful events in adult mice.
Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Fluoxetine; | 2013 |
Time course of zinc deprivation-induced alterations of mice behavior in the forced swim test.
Topics: Animals; Behavior, Animal; Corticosterone; Depression; Male; Mice; Motor Activity; Swimming; Time Fa | 2012 |
Exposure to a maternal n-3 fatty acid-deficient diet during brain development provokes excessive hypothalamic-pituitary-adrenal axis responses to stress and behavioral indices of depression and anxiety in male rat offspring later in life.
Topics: Animals; Anxiety; Behavior, Animal; Bicuculline; Brain; Corticosterone; Depression; Docosahexaenoic | 2013 |
Evidence for biological roots in the transgenerational transmission of intimate partner violence.
Topics: Adult; Age Factors; Aggression; Agonistic Behavior; Animals; Anxiety; Body Weight; Child; Child Abus | 2012 |
Depressive-like states heighten the aversion to painful stimuli in a rat model of comorbid chronic pain and depression.
Topics: Animals; Chronic Pain; Corticosterone; Depression; Disease Models, Animal; Extracellular Signal-Regu | 2012 |
Central administration of murine interferon-α induces depressive-like behavioral, brain cytokine and neurochemical alterations in mice: a mini-review and original experiments.
Topics: Animals; Behavior, Animal; Brain; Corticosterone; Cytokines; Depression; Gene Expression; Illness Be | 2013 |
Persistent effects of prior chronic exposure to corticosterone on reward-related learning and motivation in rodents.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Conditioning, Operant; C | 2013 |
Ethanol extracts from Hemerocallis citrina attenuate the decreases of brain-derived neurotrophic factor, TrkB levels in rat induced by corticosterone administration.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Corticosterone; | 2012 |
Three Chinese herbal medicines promote neuroproliferation in vitro, and reverse the effects of chronic mild stress on behavior, the HPA axis, and proliferation of hippocampal precursor cell in vivo.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Cell Line; Cell Proliferation; Corticosterone; Dep | 2012 |
Adolescence fluoxetine increases serotonergic activity in the raphe-hippocampus axis and improves depression-like behaviors in female rats that experienced neonatal maternal separation.
Topics: Animals; Animals, Newborn; Behavior, Animal; Body Weight; Corticosterone; Corticotropin-Releasing Ho | 2013 |
Metabotropic glutamate 2/3 receptor antagonists improve behavioral and prefrontal dopaminergic alterations in the chronic corticosterone-induced depression model in mice.
Topics: Animals; Antidepressive Agents; Corticosterone; Depression; Disease Models, Animal; Dopamine; Excita | 2013 |
Chronic treatment with baicalin prevents the chronic mild stress-induced depressive-like behavior: involving the inhibition of cyclooxygenase-2 in rat brain.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain; Corticosterone; Cyclooxygenase 2 Inhibitors | 2013 |
Mineralocorticoid receptor antagonist spironolactone prevents chronic corticosterone induced depression-like behavior.
Topics: Animals; Behavior, Animal; Corticosterone; Depression; Hippocampus; Hydroxyindoleacetic Acid; Hypoth | 2013 |
Individual differences in pre-carcinogen cytokine and corticosterone concentrations and depressive-like behavior predict tumor onset in rats exposed to a carcinogen.
Topics: Animals; Biomarkers; Corticosterone; Cytokines; Depression; Disease Susceptibility; Female; Individu | 2013 |
Low maternal care exacerbates adult stress susceptibility in the chronic mild stress rat model of depression.
Topics: Animals; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Disease Susceptibilit | 2012 |
Fucoidan prevents depression-like behavior in rats exposed to repeated restraint stress.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain; Brain-Derived Neurotrophic Factor; Corticos | 2013 |
Synaptic plasticity, but not hippocampal neurogenesis, mediated the counteractive effect of wolfberry on depression in rats(1).
Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents; Antimetabolites, Antineoplastic; Corticost | 2012 |
Aberrant light directly impairs mood and learning through melanopsin-expressing neurons.
Topics: Affect; Animals; Antidepressive Agents; Body Temperature Regulation; Circadian Rhythm; Cognition; Co | 2012 |
Short-term social isolation induces depressive-like behaviour and reinstates the retrieval of an aversive task: mood-congruent memory in male mice?
Topics: Affect; Animals; Avoidance Learning; Behavior, Animal; Corticosterone; Crowding; Depression; Discrim | 2013 |
Vulnerability versus resilience to prenatal stress in male and female rats; implications from gene expression profiles in the hippocampus and frontal cortex.
Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Disease Susceptibility; Epigenesis, | 2013 |
Altered GABAergic and glutamatergic activity within the rat hippocampus and amygdala in rats subjected to repeated corticosterone administration but not restraint stress.
Topics: Amygdala; Animals; Behavior, Animal; Corticosterone; Depression; Depressive Disorder; Disease Models | 2013 |
Pure docosahexaenoic acid can improve depression behaviors and affect HPA axis in mice.
Topics: Adrenocorticotropic Hormone; Animals; Corticosterone; Depression; Docosahexaenoic Acids; Fatty Acids | 2012 |
Bidirectional crosstalk between stress-induced gastric ulcer and depression under chronic stress.
Topics: Animals; Anti-Ulcer Agents; Corticosterone; Depression; Fluoxetine; Male; Mifepristone; Ranitidine; | 2012 |
Prenatal Enriched Environment improves emotional and attentional reactivity to adulthood stress.
Topics: Animals; Anxiety; Attention; Corticosterone; Depression; Emotions; Environment; Female; Freezing Rea | 2013 |
Impacts of early intervention with fluoxetine following early neonatal immune activation on depression-like behaviors and body weight in mice.
Topics: Aging; Animals; Animals, Newborn; Antidepressive Agents, Second-Generation; Behavior, Animal; Body W | 2013 |
Swimming exercise ameliorates depression-like behavior in chronically stressed rats: relevant to proinflammatory cytokines and IDO activation.
Topics: Analysis of Variance; Animals; Corticosterone; Cytokines; Depression; Disease Models, Animal; Exerci | 2013 |
Chronic subordinate colony housing (CSC) as a model of chronic psychosocial stress in male rats.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aggression; Animals; Anxiety; Behavior, Animal; Body We | 2012 |
Coenzyme Q10 displays antidepressant-like activity with reduction of hippocampal oxidative/nitrosative DNA damage in chronically stressed rats.
Topics: Animals; Antidepressive Agents; Antioxidants; Behavior, Animal; Corticosterone; Depression; Disease | 2013 |
Alteration in plasma corticosterone levels following long term oral administration of lead produces depression like symptoms in rats.
Topics: Administration, Oral; Animals; Brain Chemistry; Corticosterone; Depression; Eating; Lead; Male; Maze | 2013 |
Alcohol administration blocks stress-induced impairments in memory and anxiety, and alters hippocampal neurotransmitter receptor expression in male rats.
Topics: Animals; Anxiety; Blotting, Western; Central Nervous System Depressants; Corticosterone; Depression; | 2013 |
Flattening the corticosterone rhythm attenuates 5-HT1A autoreceptor function in the rat: relevance for depression.
Topics: Animals; Body Weight; Circadian Rhythm; Corticosterone; Dendrites; Depression; Drug Implants; Hippoc | 2003 |
Amphetamine withdrawal does not produce a depressive-like state in rats as measured by three behavioral tests.
Topics: Adrenocorticotropic Hormone; Amphetamine; Animals; Behavior, Animal; Central Nervous System Stimulan | 2003 |
Impact of chronic intermittent challenges in stressor-susceptible and resilient strains of mice.
Topics: Animals; Anxiety; Behavior, Animal; Biogenic Monoamines; Brain Chemistry; Chromatography, High Press | 2003 |
Flattening the glucocorticoid rhythm causes changes in hippocampal expression of messenger RNAs coding structural and functional proteins: implications for aging and depression.
Topics: Aging; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Pro | 2003 |
Topiramate normalizes hippocampal NPY-LI in flinders sensitive line 'depressed' rats and upregulates NPY, galanin, and CRH-LI in the hypothalamus: implications for mood-stabilizing and weight loss-inducing effects.
Topics: Affect; Animals; Anticonvulsants; Corpus Striatum; Corticosterone; Corticotropin-Releasing Hormone; | 2003 |
Implantation of a slow release corticosterone pellet induces long-term alterations in serotonergic neurochemistry in the rat brain.
Topics: Adrenal Glands; Animals; Body Weight; Carrier Proteins; Corticosterone; Depression; Disease Models, | 2003 |
Behavioral, neurochemical, and electrophysiological characterization of a genetic mouse model of depression.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adaptation, Psychological; Animals; Antidepressive Agents; A | 2003 |
Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment.
Topics: Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Bromodeoxyuridine; Cell Count; | 2003 |
SPREADING DEPRESSION AND ADRENOCORTICAL FUNCTION IN THE ADAPTATION OF THE ORGANISM TO REPEATED SHORT-TERM STRESS.
Topics: Adaptation, Physiological; Ascorbic Acid; Brain; Cerebral Cortex; Corticosterone; Decerebrate State; | 1964 |
Corticosterone attenuates the antidepressant-like effects elicited by melatonin in the forced swim test in both male and female rats.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Drug Combinations; Dru | 2003 |
Corticosterone and testosterone levels after chronic stress in an animal model of depression.
Topics: Analysis of Variance; Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Behavior, Animal; | 2003 |
Different regulation of adenylyl cyclase and rolipram-sensitive phosphodiesterase activity on the frontal cortex and hippocampus in learned helplessness rats.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Corticosterone; Cyclic AMP; Cyclic | 2003 |
Nicotine withdrawal induces subsensitivity of hypothalamic-pituitary-adrenal axis to stress in rats: implications for precipitation of depression during smoking cessation.
Topics: Adaptation, Physiological; Adrenal Cortex Function Tests; Animals; Corticosterone; Depression; Dexam | 2004 |
Forebrain-specific trkB-receptor knockout mice: behaviorally more hyperactive than "depressive".
Topics: Adrenocorticotropic Hormone; Analysis of Variance; Animals; Behavior, Animal; Corticosterone; Cortic | 2003 |
Impaired T-cell dependent humoral response and its relationship with T lymphocyte sensitivity to stress hormones in a chronic mild stress model of depression.
Topics: Analysis of Variance; Animals; Antibody Formation; Antigens; Chronic Disease; Corticosterone; Depres | 2004 |
Total sleep deprivation decreases immobility in the forced-swim test.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; | 2004 |
Dietary n-3 fatty acids selectively attenuate LPS-induced behavioral depression in mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Blood Glucose; Brain; Corticosterone; Depression; D | 2004 |
Sex differences in behavioral, neurochemical and neuroendocrine effects induced by the forced swim test in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Blotting, Northern; Brain Chemistry; Corticosterone | 2004 |
Influence of chronic interleukin-2 infusion and stressors on sickness behaviors and neurochemical change in mice.
Topics: Acute Disease; Animals; Anorexia; Behavior, Animal; Biogenic Monoamines; Brain; Cacao; Chronic Disea | 2004 |
A distinct neurochemical profile in WKY rats at baseline and in response to acute stress: implications for animal models of anxiety and depression.
Topics: Animals; Anxiety; Brain; Chromatography, High Pressure Liquid; Corticosterone; Depression; Disease M | 2004 |
Effect of repeated corticosterone injections and restraint stress on anxiety and depression-like behavior in male rats.
Topics: Aggression; Agonistic Behavior; Animals; Anxiety; Arousal; Corticosterone; Depression; Disease Model | 2005 |
Chronic treatment with the monoamine oxidase inhibitor phenelzine increases hypothalamic-pituitary-adrenocortical activity in male C57BL/6 mice: relevance to atypical depression.
Topics: Adrenal Cortex; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Analysis of Variance; Animals; | 2005 |
Corticosterone increases depression-like behavior, with some effects on predator odor-induced defensive behavior, in male and female rats.
Topics: Aggression; Analysis of Variance; Animals; Behavior, Animal; Body Weight; Corticosterone; Depression | 2004 |
Antianxiety and antidepressive behavior produced by physiological estradiol regimen may be modulated by hypothalamic-pituitary-adrenal axis activity.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Disease Models | 2005 |
Effect of chronic treatment with ladostigil (TV-3326) on anxiogenic and depressive-like behaviour and on activity of the hypothalamic-pituitary-adrenal axis in male and female prenatally stressed rats.
Topics: Age Factors; Animals; Anxiety; Behavior, Animal; Cholinesterase Inhibitors; Corticosterone; Depressi | 2005 |
Antidepressant action of agomelatine (S 20098) in a transgenic mouse model.
Topics: Acetamides; Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Behavior, Animal; Corticost | 2005 |
Two different putative genetic animal models of childhood depression.
Topics: Adrenocorticotropic Hormone; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Cort | 2006 |
Prenatal restraint stress and long-term affective consequences.
Topics: Adaptation, Physiological; Animals; Anxiety; Cell Proliferation; Corticosterone; Dentate Gyrus; Depr | 2005 |
Stressors affect the response of male and female rats to clomipramine in a model of behavioral despair (forced swim test).
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Clomipramine; Corticosterone; Depressio | 2005 |
[Effects of total triterpenes of Centella asiatica on the corticosterone levels in serum and contents of monoamine in depression rat brain].
Topics: Animals; Antidepressive Agents; Biogenic Monoamines; Brain; Centella; Corticosterone; Depression; Ma | 2005 |
Beneficial effects of exercise and its molecular mechanisms on depression in rats.
Topics: Animals; Body Weight; Brain-Derived Neurotrophic Factor; Corticosterone; Depression; Exploratory Beh | 2006 |
Effect of different doses of corticosterone on depression-like behavior and HPA axis responses to a novel stressor.
Topics: Animals; Behavior, Animal; Body Weight; Corticosterone; Depression; Disease Models, Animal; Dose-Res | 2006 |
Corticosterone-induced inhibition of gliogenesis in rat hippocampus is counteracted by electroconvulsive seizures.
Topics: Animals; Antigens; Cell Count; Cell Differentiation; Cell Proliferation; Corticosterone; Depression; | 2006 |
Antidepressant-like effect of saponins extracted from Chaihu-jia-longgu-muli-tang and its possible mechanism.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Calcium; Cell Survival; Corticosterone; Depression | 2006 |
Feeding, exploratory, anxiety- and depression-related behaviors are not altered in interleukin-6-deficient male mice.
Topics: Adrenocorticotropic Hormone; Analysis of Variance; Animals; Anxiety; Biogenic Amines; Brain; Cortico | 2006 |
The comparison of changes in behavior, neurochemistry, endocrine, and immune functions after different routes, doses and durations of administrations of IL-1beta in rats.
Topics: Animals; Arousal; Behavior, Animal; Brain; Corticosterone; Depression; Dinoprostone; Dopamine; Dose- | 2006 |
Chronobiological disturbances with hyperthermia and hypercortisolism induced by chronic mild stress in rats.
Topics: Analysis of Variance; Animals; Body Temperature; Chronobiology Disorders; Circadian Rhythm; Corticos | 2006 |
Imipramine and citalopram reverse corticosterone-induced alterations in the effects of the activation of 5-HT(1A) and 5-HT(2) receptors in rat frontal cortex.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Antidepressive Agents, Second-Generat | 2006 |
Modeling the anxiety-depression continuum hypothesis in domestic fowl chicks.
Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety; Chickens; | 2006 |
Differential regulation of neurotrophins and serotonergic function in mice with genetically reduced glucocorticoid receptor expression.
Topics: Animals; Biogenic Monoamines; Brain; Brain-Derived Neurotrophic Factor; Circadian Rhythm; Corticoste | 2007 |
Signs of attenuated depression-like behavior in vasopressin deficient Brattleboro rats.
Topics: Adaptation, Psychological; Adrenocorticotropic Hormone; Animals; Behavior, Animal; Corticosterone; D | 2007 |
Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanisms.
Topics: Alkaloids; Animals; Antidepressive Agents; Benzodioxoles; Brain-Derived Neurotrophic Factor; Cell Pr | 2007 |
Cognitive impairment associated to HPA axis hyperactivity after maternal separation in rats.
Topics: Adaptation, Psychological; Analysis of Variance; Animals; Cognition Disorders; Corticosterone; Corti | 2007 |
Chronic food restriction in young rats results in depression- and anxiety-like behaviors with decreased expression of serotonin reuptake transporter.
Topics: Animals; Animals, Newborn; Anxiety; Behavior, Animal; Brain Chemistry; Corticosterone; Depression; D | 2007 |
The role of vasopressin in chronic stress studied in a chronic mild stress model of depression.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Body Weight; Chronic Disease; Corticosterone; | 2007 |
Increase of locomotor activity underlying the behavioral disinhibition in tg2576 mice.
Topics: Adrenal Glands; Alzheimer Disease; Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; E | 2007 |
Hypothalamus-pituitary-adrenal modifications consequent to chronic stress exposure in an experimental model of depression in rats.
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Corticosterone; Corticotropin-Releasing | 2007 |
Repeated exposure to stress across the childhood-adolescent period alters rats' anxiety- and depression-like behaviors in adulthood: The importance of stressor type and gender.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Anxiety; Behavior, Animal; Body Weight | 2007 |
Intranasal immune challenge induces sex-dependent depressive-like behavior and cytokine expression in the brain.
Topics: Administration, Intranasal; Analysis of Variance; Animals; Behavior, Animal; Brain; Corticosterone; | 2008 |
Involvement of the hypothalamic-pituitary-adrenal axis in the antidepressant-like effects of mild hypoxic preconditioning in rats.
Topics: Animals; Corticosterone; Depression; Electroshock; Helplessness, Learned; Hypothalamo-Hypophyseal Sy | 2007 |
Effects of chronic and acute stressors and CRF on depression-like behavior in mice.
Topics: Acute Disease; Adaptation, Psychological; Adrenocorticotropic Hormone; Analysis of Variance; Animals | 2008 |
Repeated social defeat-induced depression-like behavioral and biological alterations in rats: involvement of cholecystokinin.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Bromodeoxyuridine; Cell Proliferati | 2008 |
Increased water temperature renders single-housed C57BL/6J mice susceptible to antidepressant treatment in the forced swim test.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Corticosterone; Data Interpretatio | 2008 |
Antidepressant-like behavioral effects of impaired cannabinoid receptor type 1 signaling coincide with exaggerated corticosterone secretion in mice.
Topics: Adaptation, Psychological; Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Corticos | 2008 |
An anti-immobility effect of exogenous corticosterone in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Desipramine; Disease M | 2008 |
Chronic corticosterone injections induce a decrease of ATP levels and sustained activation of AMP-activated protein kinase in hippocampal tissues of male mice.
Topics: Adenosine Triphosphate; Adenylate Kinase; AMP-Activated Protein Kinases; Animals; Corticosterone; De | 2008 |
Bacterial infection early in life protects against stressor-induced depressive-like symptoms in adult rats.
Topics: Animals; Animals, Newborn; Bacterial Infections; Behavior, Animal; Corticosterone; Depression; Elect | 2008 |
Antidepressant-like effect of onion (Allium cepa L.) powder in a rat behavioral model of depression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal | 2008 |
A mouse model of depression induced by repeated corticosterone injections.
Topics: Animals; Body Weight; Corticosterone; Depression; Disease Models, Animal; Hindlimb Suspension; Hippo | 2008 |
Reduced anxiety-like and depression-related behavior in neuropeptide Y Y4 receptor knockout mice.
Topics: Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; Exploratory Behavior; Female; Fever; | 2008 |
Chronic low dose corticosterone exposure decreased hippocampal cell proliferation, volume and induced anxiety and depression like behaviours in mice.
Topics: Adrenal Glands; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; | 2008 |
The immobility produced by intermittent swim stress is not mediated by serotonin.
Topics: Animals; Body Temperature; Corticosterone; Depression; Fenclonine; Immobilization; Male; Rats; Rats, | 2008 |
Evaluation of effects of previous exposure to an acute stressor before testing for depression-like behaviours in mice.
Topics: Animals; Avoidance Learning; Behavior, Animal; Corticosterone; Depression; Electroshock; Helplessnes | 2008 |
Tiagabine treatment is associated with neurochemical, immune and behavioural alterations in the olfactory bulbectomized rat model of depression.
Topics: Animals; Behavior, Animal; Brain Chemistry; Corticosterone; Depression; GABA Agonists; Immunity, Cel | 2008 |
Maternal separation of rat pups increases the risk of developing depressive-like behavior after subsequent chronic stress by altering corticosterone and neurotrophin levels in the hippocampus.
Topics: Animals; Antioxidants; Anxiety, Separation; Behavior, Animal; Chronic Disease; Corticosterone; Corti | 2008 |
Increased depressive behaviour in females and heightened corticosterone release in males to swim stress after adolescent social stress in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; | 2008 |
Disruption of the circadian output molecule prokineticin 2 results in anxiolytic and antidepressant-like effects in mice.
Topics: Animals; Anxiety; Arousal; Body Temperature; Circadian Rhythm; Corticosterone; Depression; Eating; G | 2009 |
Effect of some antidepressants on the low corticosterone concentration-induced gene transcription in LMCAT fibroblast cells.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Cell Line, Tumor; Corticosterone; | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Bifidobacterium; Biogenic Monoamines; Brain; Chrom | 2008 |
Influence of continuous infusion of interleukin-1beta on depression-related processes in mice: corticosterone, circulating cytokines, brain monoamines, and cytokine mRNA expression.
Topics: Animals; Annexin A2; Biogenic Monoamines; Brain Chemistry; Corticosterone; Cytokines; Depression; En | 2008 |
The neuropharmacological effects of electroconvulsive shock and their relationship to the therapeutic effect of electroconvulsive therapy in depression.
Topics: Anesthesia, General; Animals; Antidepressive Agents; Apomorphine; Behavior, Animal; Brain; Corticost | 1984 |
Hippocampal kindling: corticosterone modulation of induced seizures.
Topics: Adrenalectomy; Animals; Corticosterone; Depression; Electroencephalography; Hippocampus; Humans; Kin | 1984 |
Effects of zometapine, a structurally novel antidepressant, in an animal model of depression.
Topics: Animals; Antidepressive Agents; Azepines; Corticosterone; Defecation; Depression; Disease Models, An | 1984 |
The effect of acute and chronic administration of desmethylimipramine on responses to stress in rats.
Topics: Acute Disease; Animals; Anorexia; Chronic Disease; Corticosterone; Depression; Desipramine; Electros | 1984 |
Hippocampal glucocorticoid binding: serotoninergic regulation and drug effects; relevance to behavioral-endocrine activities and depression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Hippocampus; Humans; M | 1982 |
Acute and chronic stress effects on open field activity in the rat: implications for a model of depression.
Topics: Acute Disease; Animals; Chronic Disease; Corticosterone; Depression; Disease Models, Animal; Humans; | 1981 |
Further studies on a novel animal model of depression: therapeutic effects of a tricyclic antidepressant.
Topics: Acute Disease; Animals; Chronic Disease; Corticosterone; Defecation; Depression; Disease Models, Ani | 1981 |
Amphetamine and tranylcypromine in an animal model of depression: pharmacological specificity of the reversal effect.
Topics: Amphetamine; Animals; Chronic Disease; Corticosterone; Defecation; Depression; Disease Models, Anima | 1981 |
Animal model of depression: effects of electroconvulsive shock therapy.
Topics: Animals; Corticosterone; Defecation; Depression; Disease Models, Animal; Electroconvulsive Therapy; | 1981 |
Amitriptyline and scopolamine in an animal model of depression.
Topics: Amitriptyline; Animals; Antidepressive Agents; Corticosterone; Defecation; Depression; Disease Model | 1981 |
Preclinical pharmacology of FG5893: a potential anxiolytic drug with high affinity for both 5-HT1A and 5-HT2A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Avoidance Learning; Behavior, | 1994 |
Platelet 5-hydroxytryptamine (5-HT) transporter and 5-HT2A receptor binding after chronic hypercorticosteronemia, (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane administration or neurotoxin-induced depletion of central nervous system 5-HT in the rat.
Topics: Amphetamines; Animals; Blood Platelets; Brain; Brain Mapping; Carrier Proteins; Citalopram; Corticos | 1996 |
Dehydroepiandrosterone decreases behavioral despair in high- but not low-anxiety rats.
Topics: Animals; Anxiety; Arousal; Corticosterone; Dehydroepiandrosterone; Depression; Fear; Helplessness, L | 1997 |
Decreased 5-HT1A and increased 5-HT2A receptor binding after chronic corticosterone associated with a behavioural indication of depression but not anxiety.
Topics: Animals; Anti-Inflammatory Agents; Anxiety; Autoradiography; Behavior, Animal; Body Weight; Corticos | 1997 |
Forced swim test-induced neurochemical endocrine, and immune changes in the rat.
Topics: Animals; Biogenic Monoamines; Brain Chemistry; Corticosterone; Depression; Endocrine Glands; Hypotha | 1997 |
Forced swim test-induced endocrine and immune changes in the rat: effect of subacute desipramine treatment.
Topics: Adrenal Glands; Animals; Antidepressive Agents, Tricyclic; Ascorbic Acid; Corticosterone; Depression | 1998 |
A.E. Bennett Research Award. Regulation of serotonin1A, glucocorticoid, and mineralocorticoid receptor in rat and human hippocampus: implications for the neurobiology of depression.
Topics: Adrenalectomy; Animals; Antidepressive Agents; Autoradiography; Corticosterone; Depression; Hippocam | 1998 |
Differential effects of prenatal stress in two inbred strains of rats.
Topics: Animals; Avoidance Learning; Body Weight; Corticosterone; Depression; Female; Hot Temperature; Male; | 1998 |
Effects of bilateral olfactory bulbectomy on circadian rhythms of ACTH, corticosterone, motor activity and body temperature in male rats.
Topics: Adrenocorticotropic Hormone; Animals; Body Temperature Regulation; Circadian Rhythm; Corticosterone; | 1997 |
Chronic cholestasis in rats induces anhedonia and a loss of social interest.
Topics: Animals; Behavior, Animal; Cholestasis; Chronic Disease; Corticosterone; Depression; Dexamethasone; | 1998 |
[Putative contribution of the epiphyseal-adrenocortical system in the antidepressive effect of imipramine].
Topics: Adrenal Cortex; Animals; Antidepressive Agents, Tricyclic; Corticosterone; Depression; Drug Interact | 1998 |
The effect of repeated exposure to forced swimming on extracellular levels of 5-hydroxytryptamine in the rat.
Topics: Animals; Behavior, Animal; Corpus Striatum; Corticosterone; Depression; Disease Models, Animal; Extr | 1998 |
Genetic alteration of the alpha2-adrenoceptor subtype c in mice affects the development of behavioral despair and stress-induced increases in plasma corticosterone levels.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Cerebral Cortex; Corpus Striatum; Cortico | 1999 |
Alpha-1-noradrenergic neurotransmission, corticosterone, and behavioral depression.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Anti-Inflammatory Agents; Behavi | 1999 |
Olfactory bulbectomy provokes a suppression of interleukin-1beta and tumour necrosis factor-alpha production in response to an in vivo challenge with lipopolysaccharide: effect of chronic desipramine treatment.
Topics: Adrenal Cortex; Animals; Antidepressive Agents, Tricyclic; Ascorbic Acid; Behavior, Animal; Corticos | 2000 |
Inhibition of 11beta-hydroxysteroid dehydrogenase, the foeto-placental barrier to maternal glucocorticoids, permanently programs amygdala GR mRNA expression and anxiety-like behaviour in the offspring.
Topics: 11-beta-Hydroxysteroid Dehydrogenases; Amygdala; Animals; Anxiety; Behavior, Animal; Brain Chemistry | 2000 |
Dehydroepiandrosterone sulfate (DHEAS) counteracts decremental effects of corticosterone on dentate gyrus LTP. Implications for depression.
Topics: Action Potentials; Animals; Anti-Inflammatory Agents; Corticosterone; Dehydroepiandrosterone Sulfate | 2000 |
[High performance liquid chromatography of corticosteroids in patients with depression and depersonalization].
Topics: Adult; Chromatography, High Pressure Liquid; Corticosterone; Cortisone; Depersonalization; Depressio | 2000 |
Decreased body temperature dependent appearance of behavioral despair in the forced swimming test in mice.
Topics: Animals; Behavior, Animal; Blood Glucose; Body Temperature; Brain; Carbon Radioisotopes; Cold Temper | 2000 |
The novel 5-Hydroxytryptamine(1A) antagonist LY426965: effects on nicotine withdrawal and interactions with fluoxetine.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acoustic Stimulation; Animals; Body Temperature; Columbidae; | 2000 |
Hypertension and insulin resistant models have divergent propensities to learned helpless behavior in rodents.
Topics: Animals; Behavior, Animal; Biomarkers; Blood Pressure; Comorbidity; Corticosterone; Depression; Fema | 2000 |
Corticotropin-releasing hormone mRNA levels in response to chronic mild stress rise in male but not in female rats while tyrosine hydroxylase mRNA levels decrease in both sexes.
Topics: Adrenal Cortex; Animals; Corticosterone; Corticotropin-Releasing Hormone; Depression; Female; Gene E | 2001 |
Neuroendocrine and behavioral effects of repetitive transcranial magnetic stimulation in a psychopathological animal model are suggestive of antidepressant-like effects.
Topics: Adaptation, Psychological; Adrenocorticotropic Hormone; Animals; Anxiety; Behavior, Animal; Computer | 2001 |
Altered hormone levels and circadian rhythm of activity in the WKY rat, a putative animal model of depression.
Topics: Activity Cycles; Adrenocorticotropic Hormone; Animals; Behavior, Animal; Chronobiology Disorders; Co | 2001 |
Sex differences in the effects of neonatal handling on the animal's response to stress and the vulnerability for depressive behaviour.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Animals, Newborn; Corticosterone; Depression; Femal | 2002 |
Amplified behavioral and endocrine responses to forced swim stress in the Wistar-Kyoto rat.
Topics: Adrenocorticotropic Hormone; Animals; Arousal; Corticosterone; Depression; Dexamethasone; Feedback; | 2002 |
Anxiogenic and depressive-like effects, but no cognitive deficits, after repeated moderate tryptophan depletion in the rat.
Topics: Animals; Anxiety; Attention; Body Weight; Cerebral Cortex; Cognition; Corticosterone; Depression; Fo | 2002 |
Clinical implications of state-dependent learning.
Topics: Animals; Arousal; Association Learning; Bipolar Disorder; Circadian Rhythm; Corticosterone; Cues; De | 1979 |
Alterations in the hypothalamic-pituitary-adrenal axis in a proposed animal model of depression with genetic muscarinic supersensitivity.
Topics: Adrenocorticotropic Hormone; Animals; Brain Chemistry; Corticosterone; Corticotropin-Releasing Hormo | 1991 |
Effects of bilateral adrenalectomy on the induction of learned helplessness behavior.
Topics: Adrenalectomy; Animals; Corticosterone; Depression; Disease Models, Animal; Electroshock; Escape Rea | 1990 |
5-Hydroxytryptamine and corticosterone in an animal model of depression.
Topics: Animals; Corticosterone; Depression; Disease Models, Animal; Rats; Restraint, Physical; Serotonin; S | 1989 |
Endocrine function in emotionally disturbed and normal men.
Topics: 17-Ketosteroids; Adjustment Disorders; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; | 1968 |
Contraceptives, brain serotonin, and liver tryptophan pyrrolase.
Topics: Animals; Brain; Contraceptives, Oral; Corticosterone; Depression; Female; Humans; Hydroxyindoleaceti | 1970 |
Neuropsychiatric problems in systemic lupus erythematosus.
Topics: Adolescent; Adult; Cognition Disorders; Corticosterone; Cranial Nerves; Depression; Epilepsy; Female | 1972 |
Estimation of corticosteroids in human cerebral cortex after death by suicide, accident, or disease.
Topics: 17-Hydroxycorticosteroids; Accidents; Adult; Aged; Autopsy; Brain Chemistry; Cerebral Cortex; Chroma | 1972 |
Effects of adrenal hormones and stress on brain serotonin.
Topics: Adrenal Cortex Hormones; Allopurinol; Animals; Brain; Corticosterone; Depression; Depression, Chemic | 1971 |