corticosterone has been researched along with Acute Confusional Senile Dementia in 88 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " Therefore, we tested this hypothesis in the depression model of chronic administration of corticosterone (CORT) in mice and treated the animals daily with liraglutide (5 or 20 nmol/kg ip." | 7.88 | Liraglutide attenuates the depressive- and anxiety-like behaviour in the corticosterone induced depression model via improving hippocampal neural plasticity. ( Birong, L; Christian, H; Feiyu, S; Le, W; Weina, H; Yuhu, N, 2018) |
| "The anxiety status is changed along with memory impairments in intracerebroventricular colchicine injected rat model of Alzheimer Disease (cAD) due to neurodegeneration, which has been indicated to be mediated by inflammation." | 7.83 | Cox-2 Plays a Vital Role in the Impaired Anxiety Like Behavior in Colchicine Induced Rat Model of Alzheimer Disease. ( Ghosh, T; Sil, S, 2016) |
| "Depression has been considered to be both a symptom and risk factor of AD." | 5.39 | Effects of corticosterone and amyloid-beta on proteins essential for synaptic function: implications for depression and Alzheimer's disease. ( Chang, RC; Cheng, SS; Ho, YS; Hung, CH; Law, AC; Wong, GT; Wuwongse, S; Zhang, NQ, 2013) |
| " Therefore, we tested this hypothesis in the depression model of chronic administration of corticosterone (CORT) in mice and treated the animals daily with liraglutide (5 or 20 nmol/kg ip." | 3.88 | Liraglutide attenuates the depressive- and anxiety-like behaviour in the corticosterone induced depression model via improving hippocampal neural plasticity. ( Birong, L; Christian, H; Feiyu, S; Le, W; Weina, H; Yuhu, N, 2018) |
| "Compared with the control group, AD rats displayed significant spatial learning and reference memory impairments, serious anxiety disorders, obvious hypertrophy of adrenal gland, elevated corticosterone and ACTH levels in the plasma, and increased 11β-HSD1 activity in liver and groin fat pad." | 3.88 | Akebia saponin D reverses corticosterone hypersecretion in an Alzheimer's disease rat model. ( Jin, Y; Linhardt, RJ; Shen, J; Wang, R; Wang, Y; Yang, X; Yang, Z; Zhang, F, 2018) |
| "The anxiety status is changed along with memory impairments in intracerebroventricular colchicine injected rat model of Alzheimer Disease (cAD) due to neurodegeneration, which has been indicated to be mediated by inflammation." | 3.83 | Cox-2 Plays a Vital Role in the Impaired Anxiety Like Behavior in Colchicine Induced Rat Model of Alzheimer Disease. ( Ghosh, T; Sil, S, 2016) |
| " oAβ(25-35) injection did not affect general activity and temperature rhythms after 6 weeks, but decreased body weight, induced short- and long-term memory impairments, increased corticosterone plasma levels, brain oxidative (lipid peroxidation), mitochondrial (caspase-9 levels) and reticulum stress (caspase-12 levels), astroglial and microglial activation." | 3.79 | Alzheimer's disease related markers, cellular toxicity and behavioral deficits induced six weeks after oligomeric amyloid-β peptide injection in rats. ( Blayo, C; Brureau, A; Delair, B; Givalois, L; Ixart, G; Keller, E; Marchal, S; Maurice, T; Zussy, C, 2013) |
| "Besides well-known risk factors for Alzheimer's disease (AD), stress, and in particular noise stress (NS), is a lifestyle risk factor common today." | 1.51 | Gestational Stress Augments Postpartum β-Amyloid Pathology and Cognitive Decline in a Mouse Model of Alzheimer's Disease. ( Jafari, Z; Kolb, BE; Mehla, J; Mohajerani, MH, 2019) |
| "Insomnia, depression, and Alzheimer's disease are all neurodegenerative diseases and are associated with the levels of steroid hormones." | 1.51 | The internal link of serum steroid hormones levels in insomnia, depression, and Alzheimer's disease rats: Is there an effective way to distinguish among these three diseases based on potential biomarkers? ( Bi, K; Li, Q; Liu, R; Wang, Z; Xu, H; Yang, X; Zhang, Q, 2019) |
| "In the brains of patients with Alzheimer's disease, the enzymatic activities of butyrylcholinesterase (BChE) and monoamine oxidase B (MAO-B) are increased." | 1.46 | N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents. ( Brazzolotto, X; Brus, B; Colletier, JP; Coquelle, N; Gobec, S; Knez, D; Kos, J; Košak, U; Nachon, F; Pišlar, A, 2017) |
| "A common familial Alzheimer's disease transgenic model showed heightened levels of the stress hormone, corticosterone." | 1.46 | Environmental novelty exacerbates stress hormones and Aβ pathology in an Alzheimer's model. ( Fernandez-Martos, CM; King, AE; Stuart, KE; Summers, MJ; Vickers, JC, 2017) |
| " These activities, associated to a good predictive bioavailability and a lack of cytotoxicity, design it as a promising hit for further in vivo investigation." | 1.43 | Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment. ( Corvaisier, S; Cresteil, T; Dallemagne, P; El Kihel, L; Jourdan, JP; Lecoutey, C; Legay, R; Malzert-Fréon, A; Rochais, C; Since, M; Sopkova-de Oliveira Santos, J, 2016) |
| "In patients with Alzheimer's disease, in addition to the core symptoms, i." | 1.43 | Involvement of hippocampal excitability in amyloid β-induced behavioral and psychological symptoms of dementia. ( Adlard, PA; Bush, AI; Ide, K; Takeda, A; Tamano, H, 2016) |
| "Alzheimer's disease is a fatal neurodegenerative disorder with a complex etiology." | 1.42 | Isoindoline-1,3-dione derivatives targeting cholinesterases: design, synthesis and biological evaluation of potential anti-Alzheimer's agents. ( Bajda, M; Brus, B; Gobec, S; Guzior, N; Malawska, B; Rakoczy, J, 2015) |
| "Due to the complex nature of Alzheimer's disease, multi-target-directed ligand approaches are one of the most promising strategies in the search for effective treatments." | 1.42 | Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo. ( Bajda, M; Brus, B; Czerwińska, P; Filipek, B; Gobec, S; Malawska, B; Sałat, K; Więckowska, A; Więckowski, K, 2015) |
| "Depression has been considered to be both a symptom and risk factor of AD." | 1.39 | Effects of corticosterone and amyloid-beta on proteins essential for synaptic function: implications for depression and Alzheimer's disease. ( Chang, RC; Cheng, SS; Ho, YS; Hung, CH; Law, AC; Wong, GT; Wuwongse, S; Zhang, NQ, 2013) |
| "Amyloid-β plays a causative role in Alzheimer's disease." | 1.37 | Occlusal disharmony increases amyloid-β in the rat hippocampus. ( Azuma, T; Ekuni, D; Endo, Y; Irie, K; Kasuyama, K; Morita, M; Tomofuji, T, 2011) |
| "The cholinergic deficit was also responsible for a disinhibition of the negative feedback regulation of glucocorticoids." | 1.29 | AF64A-induced brain damage and its relation to dementia. ( Hörtnagl, H, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (4.55) | 18.2507 |
| 2000's | 17 (19.32) | 29.6817 |
| 2010's | 53 (60.23) | 24.3611 |
| 2020's | 14 (15.91) | 2.80 |
| Authors | Studies |
|---|---|
| Marco-Contelles, J | 1 |
| León, R | 3 |
| de los Ríos, C | 1 |
| Samadi, A | 1 |
| Bartolini, M | 3 |
| Andrisano, V | 3 |
| Huertas, O | 2 |
| Barril, X | 1 |
| Luque, FJ | 3 |
| Rodríguez-Franco, MI | 6 |
| López, B | 3 |
| López, MG | 4 |
| García, AG | 3 |
| Carreiras, Mdo C | 1 |
| Villarroya, M | 4 |
| Camps, P | 1 |
| Formosa, X | 1 |
| Galdeano, C | 1 |
| Muñoz-Torrero, D | 3 |
| Ramírez, L | 1 |
| Gómez, E | 1 |
| Isambert, N | 1 |
| Lavilla, R | 2 |
| Badia, A | 1 |
| Clos, MV | 2 |
| Mancini, F | 1 |
| Arce, MP | 4 |
| Dafni, T | 1 |
| González-Muñoz, GC | 2 |
| Pérez, C | 4 |
| Conde, S | 3 |
| Romero, A | 1 |
| del Barrio, L | 1 |
| Martín-de-Saavedra, MD | 1 |
| Egea, J | 2 |
| Di Pietro, O | 1 |
| Pérez-Areales, FJ | 2 |
| Juárez-Jiménez, J | 1 |
| Espargaró, A | 2 |
| Pérez, B | 3 |
| Sabaté, R | 2 |
| Lan, JS | 6 |
| Xie, SS | 9 |
| Li, SY | 1 |
| Pan, LF | 1 |
| Wang, XB | 9 |
| Kong, LY | 11 |
| Huang, M | 1 |
| Jiang, N | 5 |
| Guzior, N | 1 |
| Bajda, M | 2 |
| Rakoczy, J | 1 |
| Brus, B | 3 |
| Gobec, S | 4 |
| Malawska, B | 3 |
| Wang, X | 3 |
| Yu, W | 1 |
| Wang, KD | 1 |
| Li, ZR | 1 |
| Więckowska, A | 2 |
| Więckowski, K | 2 |
| Sałat, K | 1 |
| Czerwińska, P | 1 |
| Filipek, B | 1 |
| Wang, ZM | 3 |
| Li, F | 5 |
| Wu, JJ | 6 |
| Wang, J | 5 |
| Jourdan, JP | 1 |
| Since, M | 2 |
| El Kihel, L | 1 |
| Lecoutey, C | 2 |
| Corvaisier, S | 2 |
| Legay, R | 1 |
| Sopkova-de Oliveira Santos, J | 2 |
| Cresteil, T | 1 |
| Malzert-Fréon, A | 1 |
| Rochais, C | 2 |
| Dallemagne, P | 2 |
| Li, XM | 1 |
| Cai, P | 6 |
| Liu, QH | 5 |
| Xu, DQ | 1 |
| Yang, XL | 6 |
| Kołaczkowski, M | 1 |
| Bucki, A | 1 |
| Godyń, J | 1 |
| Marcinkowska, M | 1 |
| Zaręba, P | 1 |
| Siwek, A | 1 |
| Kazek, G | 1 |
| Głuch-Lutwin, M | 1 |
| Mierzejewski, P | 1 |
| Bienkowski, P | 1 |
| Sienkiewicz-Jarosz, H | 1 |
| Knez, D | 2 |
| Wichur, T | 1 |
| Košak, U | 1 |
| Coquelle, N | 1 |
| Pišlar, A | 1 |
| Nachon, F | 1 |
| Brazzolotto, X | 1 |
| Kos, J | 1 |
| Colletier, JP | 1 |
| Xia, CL | 1 |
| Wang, N | 1 |
| Guo, QL | 1 |
| Liu, ZQ | 1 |
| Wu, JQ | 1 |
| Huang, SL | 1 |
| Ou, TM | 1 |
| Tan, JH | 1 |
| Wang, HG | 1 |
| Li, D | 1 |
| Huang, ZS | 1 |
| Monjas, L | 1 |
| Gil, C | 1 |
| Zhang, T | 2 |
| Liu, Y | 2 |
| Yang, J | 1 |
| Liu, J | 4 |
| Miao, ZY | 1 |
| Ding, Y | 2 |
| Yang, HL | 3 |
| Kang, P | 1 |
| Hou, JW | 1 |
| Zhang, XY | 1 |
| Fang, SQ | 1 |
| Tang, YW | 2 |
| Wang, C | 2 |
| Xu, YX | 1 |
| Wang, H | 2 |
| Li, XK | 1 |
| Dong, SN | 1 |
| Liu, WW | 1 |
| Gong, Q | 2 |
| Wang, TD | 1 |
| Tang, Y | 1 |
| Zhu, J | 2 |
| Li, J | 2 |
| Zhang, HY | 1 |
| Mao, F | 2 |
| Huang, Q | 1 |
| Liang, N | 2 |
| Li, Q | 4 |
| Liu, W | 1 |
| Li, X | 1 |
| Xu, Y | 1 |
| Zhang, J | 1 |
| Wang, W | 1 |
| Qiu, X | 1 |
| Zhang, H | 1 |
| Reis, J | 1 |
| Cagide, F | 1 |
| Valencia, ME | 1 |
| Teixeira, J | 1 |
| Bagetta, D | 1 |
| Uriarte, E | 1 |
| Oliveira, PJ | 1 |
| Ortuso, F | 1 |
| Alcaro, S | 1 |
| Borges, F | 1 |
| Shi, CJ | 1 |
| Turcu, AL | 2 |
| Barniol-Xicota, M | 1 |
| Pont, C | 1 |
| Pivetta, D | 1 |
| De Simone, A | 1 |
| Sureda, FX | 2 |
| Vázquez, S | 2 |
| Tang, C | 1 |
| Pang, C | 1 |
| Qin, Y | 1 |
| Nong, X | 1 |
| Zhang, Z | 2 |
| Guo, J | 2 |
| Cheng, M | 2 |
| Tang, W | 1 |
| Toublet, FX | 1 |
| Lalut, J | 1 |
| Hatat, B | 1 |
| Davis, A | 1 |
| Freret, T | 1 |
| Claeysen, S | 1 |
| Boulouard, M | 1 |
| Zhou, W | 1 |
| Wan, Y | 1 |
| Wang, R | 3 |
| Fang, Y | 1 |
| Jin, Y | 2 |
| Qu, L | 1 |
| Ji, L | 1 |
| Luo, H | 1 |
| Li, S | 1 |
| Peng, W | 1 |
| Yin, F | 1 |
| Lu, D | 1 |
| Liu, X | 1 |
| Kong, L | 1 |
| Singh, YP | 1 |
| Shankar, G | 1 |
| Jahan, S | 1 |
| Singh, G | 1 |
| Kumar, N | 1 |
| Barik, A | 1 |
| Upadhyay, P | 1 |
| Singh, L | 1 |
| Kamble, K | 1 |
| Singh, GK | 1 |
| Tiwari, S | 1 |
| Garg, P | 1 |
| Gupta, S | 1 |
| Modi, G | 1 |
| Sun, X | 1 |
| Wang, Y | 2 |
| Lei, Z | 1 |
| Yue, S | 1 |
| Chen, L | 1 |
| Sun, J | 1 |
| Companys-Alemany, J | 1 |
| Phillips, MB | 1 |
| Patel, DS | 1 |
| Griñán-Ferré, C | 1 |
| Loza, MI | 1 |
| Brea, JM | 1 |
| Soto, D | 1 |
| Kurnikova, MG | 1 |
| Johnson, JW | 1 |
| Pallàs, M | 1 |
| Canet, G | 1 |
| Zussy, C | 2 |
| Hernandez, C | 1 |
| Chevallier, N | 1 |
| Marchi, N | 1 |
| Desrumaux, C | 1 |
| Givalois, L | 2 |
| Harris, BN | 1 |
| Roberts, BR | 1 |
| DiMarco, GM | 1 |
| Maldonado, KA | 1 |
| Okwunwanne, Z | 1 |
| Savonenko, AV | 1 |
| Soto, PL | 1 |
| Baeta-Corral, R | 1 |
| De la Fuente, M | 3 |
| Giménez-Llort, L | 3 |
| Bouji, M | 1 |
| Lecomte, A | 1 |
| Gamez, C | 1 |
| Blazy, K | 1 |
| Villégier, AS | 1 |
| Nguyen, ET | 1 |
| Selmanovic, D | 1 |
| Maltry, M | 1 |
| Morano, R | 1 |
| Franco-Villanueva, A | 1 |
| Estrada, CM | 1 |
| Solomon, MB | 1 |
| Tanaka, T | 1 |
| Hirai, S | 1 |
| Hosokawa, M | 1 |
| Saito, T | 1 |
| Sakuma, H | 1 |
| Saido, T | 1 |
| Hasegawa, M | 1 |
| Okado, H | 1 |
| Hendrickx, JO | 1 |
| De Moudt, S | 1 |
| Calus, E | 1 |
| Martinet, W | 1 |
| Guns, PDF | 1 |
| Roth, L | 1 |
| De Deyn, PP | 1 |
| Van Dam, D | 1 |
| De Meyer, GRY | 1 |
| Stuart, KE | 1 |
| King, AE | 1 |
| Fernandez-Martos, CM | 1 |
| Summers, MJ | 1 |
| Vickers, JC | 1 |
| Esmaeili, MH | 1 |
| Bahari, B | 1 |
| Salari, AA | 1 |
| Weina, H | 1 |
| Yuhu, N | 1 |
| Christian, H | 1 |
| Birong, L | 1 |
| Feiyu, S | 1 |
| Le, W | 1 |
| ArunSundar, M | 1 |
| Shanmugarajan, TS | 1 |
| Ravichandiran, V | 1 |
| Shen, J | 1 |
| Yang, X | 2 |
| Yang, Z | 1 |
| Zhang, F | 1 |
| Linhardt, RJ | 1 |
| Jafari, Z | 1 |
| Mehla, J | 1 |
| Kolb, BE | 1 |
| Mohajerani, MH | 1 |
| Wang, Z | 1 |
| Zhang, Q | 1 |
| Liu, R | 1 |
| Xu, H | 2 |
| Bi, K | 1 |
| Rothman, SM | 1 |
| Herdener, N | 1 |
| Frankola, KA | 1 |
| Mughal, MR | 1 |
| Mattson, MP | 1 |
| Morgese, MG | 1 |
| Tucci, P | 1 |
| Colaianna, M | 1 |
| Zotti, M | 1 |
| Cuomo, V | 1 |
| Schiavone, S | 1 |
| Trabace, L | 1 |
| Wuwongse, S | 1 |
| Cheng, SS | 1 |
| Wong, GT | 1 |
| Hung, CH | 1 |
| Zhang, NQ | 1 |
| Ho, YS | 1 |
| Law, AC | 1 |
| Chang, RC | 1 |
| Hohsfield, LA | 1 |
| Daschil, N | 1 |
| Orädd, G | 1 |
| Strömberg, I | 1 |
| Humpel, C | 1 |
| Cho, J | 1 |
| Shin, MK | 1 |
| Kim, D | 1 |
| Lee, I | 1 |
| Kim, S | 1 |
| Kang, H | 1 |
| Baglietto-Vargas, D | 1 |
| Chen, Y | 1 |
| Suh, D | 1 |
| Ager, RR | 1 |
| Rodriguez-Ortiz, CJ | 1 |
| Medeiros, R | 1 |
| Myczek, K | 1 |
| Green, KN | 3 |
| Baram, TZ | 1 |
| LaFerla, FM | 3 |
| Rodriguez-Perdigon, M | 1 |
| Solas, M | 2 |
| Ramirez, MJ | 2 |
| Sil, S | 1 |
| Ghosh, T | 1 |
| Soultanov, V | 1 |
| Fedotova, J | 1 |
| Nikitina, T | 1 |
| Roschin, V | 1 |
| Ordyan, N | 1 |
| Hritcu, L | 1 |
| Tamano, H | 1 |
| Ide, K | 1 |
| Adlard, PA | 1 |
| Bush, AI | 1 |
| Takeda, A | 1 |
| Lee, KW | 1 |
| Kim, JB | 1 |
| Seo, JS | 1 |
| Kim, TK | 1 |
| Im, JY | 1 |
| Baek, IS | 1 |
| Kim, KS | 1 |
| Lee, JK | 1 |
| Han, PL | 1 |
| Arranz, L | 2 |
| Maté, I | 1 |
| Lewejohann, L | 3 |
| Reefmann, N | 1 |
| Widmann, P | 1 |
| Ambrée, O | 4 |
| Herring, A | 2 |
| Keyvani, K | 4 |
| Paulus, W | 4 |
| Sachser, N | 4 |
| De Castro, NM | 1 |
| Baeza, I | 1 |
| Bedrosian, TA | 1 |
| Herring, KL | 1 |
| Weil, ZM | 1 |
| Nelson, RJ | 1 |
| Ekuni, D | 1 |
| Tomofuji, T | 1 |
| Irie, K | 1 |
| Azuma, T | 1 |
| Endo, Y | 1 |
| Kasuyama, K | 1 |
| Morita, M | 1 |
| Briones, A | 1 |
| Gagno, S | 1 |
| Martisova, E | 1 |
| Dobarro, M | 1 |
| Aisa, B | 2 |
| Tordera, R | 1 |
| Ramírez, M | 1 |
| Jeong, YH | 2 |
| Kim, JM | 1 |
| Yoo, J | 2 |
| Lee, SH | 2 |
| Kim, HS | 2 |
| Suh, YH | 2 |
| Cuadrado-Tejedor, M | 1 |
| Ricobaraza, A | 1 |
| Frechilla, D | 1 |
| Franco, R | 1 |
| Pérez-Mediavilla, A | 1 |
| Garcia-Osta, A | 1 |
| Dong, H | 1 |
| Murphy, KM | 1 |
| Meng, L | 1 |
| Montalvo-Ortiz, J | 1 |
| Zeng, Z | 1 |
| Kolber, BJ | 1 |
| Zhang, S | 1 |
| Muglia, LJ | 1 |
| Csernansky, JG | 1 |
| Brureau, A | 1 |
| Keller, E | 1 |
| Marchal, S | 1 |
| Blayo, C | 1 |
| Delair, B | 1 |
| Ixart, G | 1 |
| Maurice, T | 1 |
| Yuan, Q | 1 |
| Su, H | 1 |
| Chau, WH | 1 |
| Toa Ng, C | 1 |
| Huang, JD | 1 |
| Wu, W | 1 |
| Lin, ZX | 1 |
| Touma, C | 3 |
| Görtz, N | 2 |
| Palme, R | 3 |
| Schwarze-Eicker, K | 1 |
| Helm, KA | 1 |
| Ziegler, DR | 1 |
| Gallagher, M | 1 |
| Park, CH | 1 |
| Shin, KY | 1 |
| Ahn, SM | 1 |
| Emson, PC | 1 |
| Pedersen, WA | 1 |
| McMillan, PJ | 1 |
| Kulstad, JJ | 1 |
| Leverenz, JB | 1 |
| Craft, S | 1 |
| Haynatzki, GR | 1 |
| Billings, LM | 2 |
| Roozendaal, B | 1 |
| McGaugh, JL | 2 |
| Gil-Bea, FJ | 1 |
| Schliebs, R | 1 |
| Clinton, LK | 1 |
| Caccamo, A | 1 |
| Ngo, J | 1 |
| Oddo, S | 1 |
| Cracchiolo, JR | 1 |
| Mori, T | 1 |
| Nazian, SJ | 1 |
| Tan, J | 1 |
| Potter, H | 1 |
| Arendash, GW | 1 |
| Richter, H | 1 |
| Schäbitz, WR | 1 |
| Behl, C | 1 |
| Widmann, M | 1 |
| Trapp, T | 1 |
| Holsboer, F | 1 |
| Hörtnagl, H | 1 |
| Gordon, I | 1 |
| Ben-Eliyahu, S | 1 |
| Rosenne, E | 1 |
| Sehayek, E | 1 |
| Michaelson, DM | 1 |
| Zoli, M | 1 |
| Picciotto, MR | 1 |
| Ferrari, R | 1 |
| Cocchi, D | 1 |
| Changeux, JP | 1 |
| Gouras, GK | 1 |
| Gross, RS | 1 |
| Greenfield, JP | 1 |
| Hai, B | 1 |
| Greengard, P | 1 |
1 review available for corticosterone and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Gender-specific neuroimmunoendocrine aging in a triple-transgenic 3xTg-AD mouse model for Alzheimer's disease and its relation with longevity.
Topics: Aging; Alzheimer Disease; Animals; Corticosterone; Cytokines; Disease Models, Animal; Estrogens; Fem | 2008 |
87 other studies available for corticosterone and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Blood-Brain Barrier; Butyrylcholines | 2009 |
Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases | 2009 |
Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Cataly | 2009 |
N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antineoplastic Agents; Butyrylcholinesterase; Calcium; Cel | 2011 |
Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting β-amyloid, tau, and cholinesterase pathologies.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cholinesterase Inhibitors; Cholinesterases; Dose-Response | 2014 |
Design, synthesis and evaluation of novel tacrine-(β-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain B | 2014 |
Multifunctional coumarin derivatives: monoamine oxidase B (MAO-B) inhibition, anti-β-amyloid (Aβ) aggregation and metal chelation properties against Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Binding Sites; Blood-Brain Barrier; Cell Line, Tu | 2015 |
Isoindoline-1,3-dione derivatives targeting cholinesterases: design, synthesis and biological evaluation of potential anti-Alzheimer's agents.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Cholinesterases; Drug Delivery Systems; Drug | 2015 |
Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Benzopyrans; Blood-Brain Barrier; Brain; Cell Survival; Cel | 2015 |
Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo.
Topics: Acetylcholinesterase; Alzheimer Disease; Amnesia; Amyloid beta-Peptides; Animals; Blood-Brain Barrie | 2015 |
Design, synthesis and biological evaluation of novel donepezil-coumarin hybrids as multi-target agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Butyrylcholinesterase; Cell Line, Tumor; Cholinesterase Inhibitors; Chol | 2016 |
Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Benzyl Compounds; Cell Proliferation; Dose-R | 2016 |
Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer's disease based on the fusion of donepezil and melatonin.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain B | 2016 |
Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Cell S | 2016 |
Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Cataly | 2016 |
N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Butyrylcholinesterase; Cell Death; Cell Line; Cholinestera | 2017 |
Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Blood-Brain Barrier; Cell Death; Cell Line; | 2017 |
Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia.
Topics: Alzheimer Disease; Animals; Brain Ischemia; Calcium Channel Blockers; Cholinesterase Inhibitors; Don | 2017 |
Design, synthesis and biological activity of novel donepezil derivatives bearing N-benzyl pyridinium moiety as potent and dual binding site acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Cell S | 2017 |
Synthesis and pharmacological evaluation of novel chromone derivatives as balanced multifunctional agents against Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Apoptosis; Binding Sites; Blood-Bra | 2017 |
Design, synthesis and evaluation of coumarin-pargyline hybrids as novel dual inhibitors of monoamine oxidases and amyloid-β aggregation for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Survival; Coumarins; Dose-Response Relations | 2017 |
Design, synthesis and biological evaluation of novel coumarin-N-benzyl pyridinium hybrids as multi-target agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cholinesterase Inhibitors; | 2017 |
Novel cinnamamide-dibenzylamine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Benzylamines; Blood-Retinal Barrier; | 2017 |
Design, synthesis, and evaluation of salicyladimine derivatives as multitarget-directed ligands against Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Survival; Dose-Response Relationship, Drug; | 2017 |
Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; | 2018 |
Design, synthesis and biological evaluation of new coumarin-dithiocarbamate hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Cell L | 2018 |
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Cholin | 2018 |
Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors.
Topics: Alzheimer Disease; Blood-Brain Barrier; Cholinesterase Inhibitors; Cholinesterases; Chromones; Drug | 2018 |
Synthesis and evaluation of isoprenylation-resveratrol dimer derivatives against Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Antioxidants; Blood-Brain Barrier; Cell Line; Dimerization; Humans; Mice | 2019 |
A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors.
Topics: Acetylcholinesterase; Adamantane; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitor | 2019 |
Design, synthesis and biological evaluation of rasagiline-clorgyline hybrids as novel dual inhibitors of monoamine oxidase-B and amyloid-β aggregation against Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Line, Tumor; Cell Survival; Clorgyline; Dose | 2020 |
Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT
Topics: Alzheimer Disease; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relation | 2021 |
Design, synthesis, and biological evaluation of novel xanthone-alkylbenzylamine hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Benzothiazoles; Benzylamines; Biphen | 2021 |
Synthesis and evaluation of multi-target-directed ligands with BACE-1 inhibitory and Nrf2 agonist activities as potential agents against Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Antioxidants; Aspart | 2021 |
Further SAR studies on natural template based neuroprotective molecules for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Biological Products; Biphenyl Compou | 2021 |
Development of 5-hydroxyl-1-azabenzanthrone derivatives as dual binding site and selective acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Binding Sites | 2022 |
Design, synthesis, and in vitro and in vivo characterization of new memantine analogs for Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Caenorhabditis elegans; Disease Models, Animal; Memantine; Mice; Recepto | 2022 |
Chronic Glucocorticoids Consumption Triggers and Worsens Experimental Alzheimer's Disease-Like Pathology by Detrimental Immune Modulations.
Topics: Alzheimer Disease; Animals; Corticosterone; Disease Models, Animal; Drinking Water; Glucocorticoids; | 2022 |
Hypothalamic-pituitary-adrenal (HPA) axis activity and anxiety-like behavior during aging: A test of the glucocorticoid cascade hypothesis in amyloidogenic APPswe/PS1dE9 mice.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anxiety; Corticosterone; Female; Ghrelin; | 2023 |
Sex-dependent worsening of NMDA-induced responses, anxiety, hypercortisolemia, and organometry of early peripheral immunoendocrine impairment in adult 3xTg-AD mice and their long-lasting ontogenic modulation by neonatal handling.
Topics: Alzheimer Disease; Animals; Anxiety; Corticosterone; Disease Models, Animal; Female; Male; Mice; Mic | 2023 |
Impact of Cerebral Radiofrequency Exposures on Oxidative Stress and Corticosterone in a Rat Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Animals; Cell Phone; Corticosterone; Electromagnetic Fields; Heme Oxygenase (Decy | 2020 |
Endocrine stress responsivity and social memory in 3xTg-AD female and male mice: A tale of two experiments.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Corticosterone; Disease Models, Animal; Female; M | 2020 |
Early-life stress induces the development of Alzheimer's disease pathology via angiopathy.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Behavior, Animal; Blood Vessels; Blood-B | 2021 |
Serum Corticosterone and Insulin Resistance as Early Biomarkers in the hAPP23 Overexpressing Mouse Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Biomarkers; Cognitive Dysfunction; Corti | 2021 |
Environmental novelty exacerbates stress hormones and Aβ pathology in an Alzheimer's model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Corticosterone; D | 2017 |
ATP-sensitive potassium-channel inhibitor glibenclamide attenuates HPA axis hyperactivity, depression- and anxiety-related symptoms in a rat model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anxiety; Corticosterone; Depression; Disease Mode | 2018 |
Liraglutide attenuates the depressive- and anxiety-like behaviour in the corticosterone induced depression model via improving hippocampal neural plasticity.
Topics: Alzheimer Disease; Animals; Antidepressive Agents; Anxiety; Corticosterone; Depression; Depressive D | 2018 |
3,4-Dihydroxyphenylethanol Assuages Cognitive Impulsivity in Alzheimer's Disease by Attuning HPA-Axis via Differential Crosstalk of α7 nAChR with MicroRNA-124 and HDAC6.
Topics: alpha Karyopherins; alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Animals; Antioxidant | 2018 |
Akebia saponin D reverses corticosterone hypersecretion in an Alzheimer's disease rat model.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adipose Tissue; Adrenal Glands; Alzheimer Disease; Amyl | 2018 |
Gestational Stress Augments Postpartum β-Amyloid Pathology and Cognitive Decline in a Mouse Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cognitive Dysfunction; Corticosterone; Dis | 2019 |
The internal link of serum steroid hormones levels in insomnia, depression, and Alzheimer's disease rats: Is there an effective way to distinguish among these three diseases based on potential biomarkers?
Topics: Alzheimer Disease; Animals; Bayes Theorem; Biomarkers; Calibration; Chromatography, High Pressure Li | 2019 |
Chronic mild sleep restriction accentuates contextual memory impairments, and accumulations of cortical Aβ and pTau in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Anim | 2013 |
Modulatory activity of soluble beta amyloid on HPA axis function in rats.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Avoidance Learning; Brain; Corticosterone; Cortic | 2014 |
Effects of corticosterone and amyloid-beta on proteins essential for synaptic function: implications for depression and Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Anti-Inflammatory Agents; Autophagy; Blotting, Western; Ce | 2013 |
Vascular pathology of 20-month-old hypercholesterolemia mice in comparison to triple-transgenic and APPSwDI Alzheimer's disease mouse models.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Blood-Brain Barrier; Cerebral Ventricles | 2014 |
Treadmill Running Reverses Cognitive Declines due to Alzheimer Disease.
Topics: Alzheimer Disease; Amyloid; Animals; Brain-Derived Neurotrophic Factor; Cognition Disorders; Cortico | 2015 |
Short-term modern life-like stress exacerbates Aβ-pathology and synapse loss in 3xTg-AD mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cells, Cultured; Corticosterone; Corticotropin-Re | 2015 |
JNK: A Putative Link Between Insulin Signaling and VGLUT1 in Alzheimer's Disease.
Topics: Aged; Alzheimer Disease; Animals; Brain; Corticosterone; Disease Models, Animal; Female; Humans; Ins | 2016 |
Cox-2 Plays a Vital Role in the Impaired Anxiety Like Behavior in Colchicine Induced Rat Model of Alzheimer Disease.
Topics: Alzheimer Disease; Animals; Anxiety; Behavior, Animal; Colchicine; Corticosterone; Cyclooxygenase 2; | 2016 |
Antidepressant-Like Effect of Ropren® in β-Amyloid-(25-35) Rat Model of Alzheimer's Disease with Altered Levels of Androgens.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Androgens; Animals; Antidepressive Agents; Corticosterone; | 2017 |
Involvement of hippocampal excitability in amyloid β-induced behavioral and psychological symptoms of dementia.
Topics: Aggression; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anxiety; Behavior, Animal; Cognition; | 2016 |
Behavioral stress accelerates plaque pathogenesis in the brain of Tg2576 mice via generation of metabolic oxidative stress.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Aniline Compounds; Animals | 2009 |
Transgenic Alzheimer mice in a semi-naturalistic environment: more plaques, yet not compromised in daily life.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Behavior, A | 2009 |
Effect of environmental enrichment on the immunoendocrine aging of male and female triple-transgenic 3xTg-AD mice for Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cell Proliferation; Chemotaxis; C | 2011 |
Altered temporal patterns of anxiety in aged and amyloid precursor protein (APP) transgenic mice.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Anxiety; Basal Nucleus of Meynert | 2011 |
Occlusal disharmony increases amyloid-β in the rat hippocampus.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Caspase 3; Corticosterone; Dental Occlusion; Hipp | 2011 |
Stress-induced anhedonia is associated with an increase in Alzheimer's disease-related markers.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Anhedonia; Animals; | 2012 |
Environmental enrichment compensates for the effects of stress on disease progression in Tg2576 mice, an Alzheimer's disease model.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of V | 2011 |
Chronic mild stress accelerates the onset and progression of the Alzheimer's disease phenotype in Tg2576 mice.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Chro | 2012 |
Corticotrophin releasing factor accelerates neuropathology and cognitive decline in a mouse model of Alzheimer's disease.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of V | 2012 |
Alzheimer's disease related markers, cellular toxicity and behavioral deficits induced six weeks after oligomeric amyloid-β peptide injection in rats.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Body Temperature; Body Weight; | 2013 |
Behavioral stress fails to accelerate the onset and progression of plaque pathology in the brain of a mouse model of Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Brain; Cerebral Cortex; | 2013 |
Age- and sex-dependent development of adrenocortical hyperactivity in a transgenic mouse model of Alzheimer's disease.
Topics: Age Factors; Alzheimer Disease; Amyloid; Amyloid beta-Protein Precursor; Animals; Anxiety; Body Weig | 2004 |
Habituation to stress and dexamethasone suppression in rats with selective basal forebrain cholinergic lesions.
Topics: Aging; Alzheimer Disease; Animals; Antibodies, Monoclonal; Cholinergic Fibers; Corticosterone; Dener | 2004 |
Activity changes and marked stereotypic behavior precede Abeta pathology in TgCRND8 Alzheimer mice.
Topics: Adrenal Medulla; Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Behavior, Animal | 2006 |
Chronic stress accelerates learning and memory impairments and increases amyloid deposition in APPV717I-CT100 transgenic mice, an Alzheimer's disease model.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cerebral Cortex; Chronic Disease; Cortic | 2006 |
Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Behavior, Anim | 2006 |
Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein | 2006 |
Increase of locomotor activity underlying the behavioral disinhibition in tg2576 mice.
Topics: Adrenal Glands; Alzheimer Disease; Animals; Anxiety; Behavior, Animal; Corticosterone; Depression; E | 2007 |
Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Animals; Avoidance Learning; Brain; Cognition | 2007 |
Enhanced cognitive activity--over and above social or physical activity--is required to protect Alzheimer's mice against cognitive impairment, reduce Abeta deposition, and increase synaptic immunoreactivity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Brain; Cognition; Cognition | 2007 |
Wheel-running in a transgenic mouse model of Alzheimer's disease: protection or symptom?
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Corticoster | 2008 |
17-beta estradiol protects neurons from oxidative stress-induced cell death in vitro.
Topics: Aldosterone; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Antioxidants; | 1995 |
AF64A-induced brain damage and its relation to dementia.
Topics: Acetylcholine; Alzheimer Disease; Animals; Aziridines; Brain Damage, Chronic; Choline; Choline O-Ace | 1994 |
Derangement in stress response of apolipoprotein E-deficient mice.
Topics: Alzheimer Disease; Analysis of Variance; Animals; Apolipoproteins E; Corticosterone; Disease Models, | 1996 |
Increased neurodegeneration during ageing in mice lacking high-affinity nicotine receptors.
Topics: Aging; Alzheimer Disease; Animals; Atrophy; Biomarkers; Brain; Corticosterone; Disease Models, Anima | 1999 |
Testosterone reduces neuronal secretion of Alzheimer's beta-amyloid peptides.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Protein Precursor; Animals; Cholesterol; Cortic | 2000 |