corosolic-acid has been researched along with Ovarian-Neoplasms* in 1 studies
1 review(s) available for corosolic-acid and Ovarian-Neoplasms
| Article | Year |
|---|---|
Discovery of Natural Ursane-type SENP1 Inhibitors and the Platinum Resistance Reversal Activity Against Human Ovarian Cancer Cells: A Structure-Activity Relationship Study.
Platinum-resistant ovarian cancer is one of the most common and refractory gynecologic cancers around the world. The SENP1/JAK2 (small ubiquitin-like modifier-specific protease 1/Janus activating kinase 2) axis activation has been proposed as a critical mechanism in platinum-resistant ovarian cancer, and as such, SENP1 inhibitors become a feasible alternative to reverse platinum resistance. In this work, 29 commercially available natural ursane-type aglycones were tested for their SENP1 inhibitory activities, among which 12 aglycones showed IC Topics: Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cisplatin; Cysteine Endopeptidases; Drug Resistance, Neoplasm; Female; Humans; Molecular Docking Simulation; Ovarian Neoplasms; Structure-Activity Relationship; Triterpenes | 2022 |