coriaria-lactone and Seizures

coriaria-lactone has been researched along with Seizures* in 4 studies

Other Studies

4 other study(ies) available for coriaria-lactone and Seizures

ArticleYear
Inhibition of mTOR Pathway by Rapamycin Decreases P-glycoprotein Expression and Spontaneous Seizures in Pharmacoresistant Epilepsy.
    Journal of molecular neuroscience : MN, 2017, Volume: 61, Issue:4

    The mammalian target of rapamycin (mTOR) has been demonstrated to mediate multidrug resistance in various tumors by inducing P-glycoprotein (P-gp) overexpression. Here, we investigated the correlation between the mTOR pathway and P-gp expression in pharmacoresistant epilepsy. Temporal cortex specimens were obtained from patients with refractory mesial temporal lobe epilepsy (mTLE) and age-matched controls who underwent surgeries at West China Hospital of Sichuan University between June 2014 and May 2015. We established a rat model of epilepsy kindled by coriaria lactone (CL) and screened pharmacoresistant rats (non-responders) using phenytoin. Non-responders were treated for 4 weeks with vehicle only or with the mTOR pathway inhibitor rapamycin at doses of 1, 3, and 6 mg/kg. Western blotting and immunohistochemistry were used to detect the expression of phospho-S6 (P-S6) and P-gp at different time points (1 h, 8 h, 1 day, 3 days, 1 weeks, 2 weeks, and 4 weeks) after the onset of treatment. Overexpression of P-S6 and P-gp was detected in both refractory mTLE patients and non-responder rats. Rapamycin showed an inhibitory effect on P-S6 and P-gp expression 1 week after treatment in rats. In addition, the expression levels of P-S6 and P-gp in the 6 mg/kg group were significantly lower than those in the 1 mg/kg or the 3 mg/kg group at the same time points (all P < 0.05). Moreover, rapamycin decreased the duration and number of CL-induced seizures, as well as the stage of non-responders (all P < 0.05). The current study indicates that the mTOR signaling pathway plays a critical role in P-gp expression in drug-resistant epilepsy. Inhibition of the mTOR pathway by rapamycin may be a potential therapeutic approach for pharmacoresistant epilepsy.

    Topics: Adult; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Case-Control Studies; Drug Resistant Epilepsy; Female; Humans; Lactones; Male; Phenytoin; Rats; Rats, Sprague-Dawley; Seizures; Sirolimus; TOR Serine-Threonine Kinases

2017
[Emergency treatment and care of acute Coriaria smica maxim poisoning].
    Zhonghua hu li za zhi = Chinese journal of nursing, 1991, Volume: 26, Issue:7

    Topics: Adolescent; Child; Child, Preschool; Female; Humans; Lactones; Male; Plants, Toxic; Poisoning; Seizures

1991
[Successive convulsion induced by coriaria lactone in 5-day-old rats].
    Sichuan yi xue yuan xue bao = Acta Academiae Medicinae Sichuan, 1985, Volume: 16, Issue:4

    Topics: Age Factors; Animals; Electroencephalography; Lactones; Rats; Rats, Inbred Strains; Seizures

1985
[Damage of experimental coriaria lactone convulsion on immature rat brain development and the protective effect of glucose].
    Sichuan yi xue yuan xue bao = Acta Academiae Medicinae Sichuan, 1985, Volume: 16, Issue:4

    Topics: Animals; Brain; Brain Chemistry; DNA; Glucose; Lactones; Rats; Seizures

1985