coriaria-lactone and Epilepsy--Tonic-Clonic

Topics: Animals; Epilepsy, Tonic-Clonic; Hippocampus; Lactones; Male; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley

In the present experiment, SC1001Na synthesized by West China University of Medical Sciences was used for studying to resist epilepsy induced by coriaria lactone. Forty-two normal male rabbits weighing 1.7-2.5 kg were randomly divided into four groups. The animals of the control group received coriaria lactone (3 mg/kg, i.m.). The animals in each of the experimental groups were injected separately with SC1001Na (100, 200 and 300 mg/kg, i.p.), but the control animals were not injected with SC1001Na. Thirty minutes later, the animals of the experimental groups were injected with the same dose of coriaria lactone as the control animals. The behavior of all animals before and after injection were observed continuously in 4-5 hours. The ECoG of eight animals of them were observed at the same time with telemetric method. The results of experiments indicated that SC1001Na is effective on epilepsy induced by coriaria lactone, in decreasing seizure rate, lengthening latent period, reducing seizure degree, as well as in decreasing mortality.

Topics: Animals; Anticonvulsants; Cinnamates; Electroencephalography; Epilepsy, Tonic-Clonic; Lactones; Male; Rabbits