copper-bis(3-5-diisopropylsalicylate) and Inflammation

copper-bis(3-5-diisopropylsalicylate) has been researched along with Inflammation* in 2 studies

Other Studies

2 other study(ies) available for copper-bis(3-5-diisopropylsalicylate) and Inflammation

Article	Year
Oxidant-dependent metabolic activation of polycyclic aromatic hydrocarbons by phorbol ester-stimulated human polymorphonuclear leukocytes: possible link between inflammation and cancer. Proceedings of the National Academy of Sciences of the United States of America, 1985, Volume: 82, Issue:15 Oxidants, such as those generated by metabolically activated phagocytes in inflammation, have been implicated in the metabolic activation of carcinogens, and in this study we demonstrate that the interaction of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene (BP 7,8-dihydrodiol) with phorbol ester-stimulated polymorphonuclear leukocytes (PMNs) results in the generation of both a chemiluminescent intermediate and one that covalently binds to DNA. Cu(II)(3,5-diisopropylsalicylic acid)2 (CuDIPS), a biomimetic superoxide dismutase, and azide, a myeloperoxidase inhibitor, inhibited both of these reactions, indicating a dependency on oxygen-derived oxidants in these hydrocarbon-activation processes. Concordant with the formation of a carcinogen-DNA adduct, the admixture of BP 7,8-dihydrodiol and phorbol ester-stimulated PMNs elicited mutagenesis in Salmonella typhimurium strain TA100. 7,8-Dihydro-BP and BP cis-7,8-dihydrodiol were also mutagenic, whereas derivatives lacking a double bond at the 9,10 position were not. These results demonstrate that oxidants generated by metabolically stimulated PMNs can activate penultimate polycyclic aromatic hydrocarbons to a genotoxic metabolite and further defines a role for inflammation in carcinogenesis. Topics: Azides; Benzopyrenes; Biotransformation; Dihydroxydihydrobenzopyrenes; DNA; Humans; Inflammation; Luminescent Measurements; Mutation; Neutrophils; Oxidation-Reduction; Peroxidase; Salicylates; Superoxides; Tetradecanoylphorbol Acetate	1985
Effects of anethole dithiolthione and 2(3)-tert-butyl-4-hydroxyanisole on schistosome granuloma formation. Parasite immunology, 1985, Volume: 7, Issue:6 Administration of the antioxidants 2(3)-tert-butyl-4-hydroxyanisole (BHA) or 5-(P-methoxyphenyl)-3H-1,2-dithiol-3-thione (ADT) to female CD-1 mice starting 4 weeks after infection with 70 cercariae of Schistosoma mansoni resulted in a decrease in the size of the inner fibrotic region of the hepatic granuloma. The cellular composition of the granuloma was not altered by treatment with these two compounds. The administration of the specific superoxide scavenger copper diisopropylsalicylate (CuDIPS) resulted in a similar decrease in granuloma size, suggesting a role of superoxide radicals in the granulomatous response. Topics: Anethole Trithione; Animals; Anisoles; Antioxidants; Butylated Hydroxytoluene; Chemotaxis, Leukocyte; Female; Free Radicals; Granuloma; Inflammation; Liver Diseases, Parasitic; Mice; Ovum; Oxygen; Salicylates; Schistosoma mansoni; Schistosomiasis mansoni; Superoxides; Triglycerides	1985

Article

Year

Oxidant-dependent metabolic activation of polycyclic aromatic hydrocarbons by phorbol ester-stimulated human polymorphonuclear leukocytes: possible link between inflammation and cancer.

Proceedings of the National Academy of Sciences of the United States of America, 1985, Volume: 82, Issue:15

Oxidants, such as those generated by metabolically activated phagocytes in inflammation, have been implicated in the metabolic activation of carcinogens, and in this study we demonstrate that the interaction of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene (BP 7,8-dihydrodiol) with phorbol ester-stimulated polymorphonuclear leukocytes (PMNs) results in the generation of both a chemiluminescent intermediate and one that covalently binds to DNA. Cu(II)(3,5-diisopropylsalicylic acid)2 (CuDIPS), a biomimetic superoxide dismutase, and azide, a myeloperoxidase inhibitor, inhibited both of these reactions, indicating a dependency on oxygen-derived oxidants in these hydrocarbon-activation processes. Concordant with the formation of a carcinogen-DNA adduct, the admixture of BP 7,8-dihydrodiol and phorbol ester-stimulated PMNs elicited mutagenesis in Salmonella typhimurium strain TA100. 7,8-Dihydro-BP and BP cis-7,8-dihydrodiol were also mutagenic, whereas derivatives lacking a double bond at the 9,10 position were not. These results demonstrate that oxidants generated by metabolically stimulated PMNs can activate penultimate polycyclic aromatic hydrocarbons to a genotoxic metabolite and further defines a role for inflammation in carcinogenesis.

Topics: Azides; Benzopyrenes; Biotransformation; Dihydroxydihydrobenzopyrenes; DNA; Humans; Inflammation; Luminescent Measurements; Mutation; Neutrophils; Oxidation-Reduction; Peroxidase; Salicylates; Superoxides; Tetradecanoylphorbol Acetate

1985

Effects of anethole dithiolthione and 2(3)-tert-butyl-4-hydroxyanisole on schistosome granuloma formation.

Parasite immunology, 1985, Volume: 7, Issue:6

Administration of the antioxidants 2(3)-tert-butyl-4-hydroxyanisole (BHA) or 5-(P-methoxyphenyl)-3H-1,2-dithiol-3-thione (ADT) to female CD-1 mice starting 4 weeks after infection with 70 cercariae of Schistosoma mansoni resulted in a decrease in the size of the inner fibrotic region of the hepatic granuloma. The cellular composition of the granuloma was not altered by treatment with these two compounds. The administration of the specific superoxide scavenger copper diisopropylsalicylate (CuDIPS) resulted in a similar decrease in granuloma size, suggesting a role of superoxide radicals in the granulomatous response.

Topics: Anethole Trithione; Animals; Anisoles; Antioxidants; Butylated Hydroxytoluene; Chemotaxis, Leukocyte; Female; Free Radicals; Granuloma; Inflammation; Liver Diseases, Parasitic; Mice; Ovum; Oxygen; Salicylates; Schistosoma mansoni; Schistosomiasis mansoni; Superoxides; Triglycerides

1985