copper-bis(3-5-diisopropylsalicylate) and Chronic-Disease

copper-bis(3-5-diisopropylsalicylate) has been researched along with Chronic-Disease* in 1 studies

Other Studies

1 other study(ies) available for copper-bis(3-5-diisopropylsalicylate) and Chronic-Disease

ArticleYear
Bioavailable copper complexes offer a physiologic approach to treatment of chronic diseases.
    Advances in experimental medicine and biology, 1989, Volume: 258

    Copper (II)2(3,5-Diisopropylsalicylate)4(H2O)2 has been found to have antiinflammatory, antiulcer, anticonvulsant, anticancer, anticarcinogenic, antimutagenic, and radiation recovery activities and it prevents reperfusion injury. To study pharmacokinetic parameters accounting for these pharmacological effects the double labeled 67Cu(II)2(carboxy-14C-3,5-diisopropylsalicylate)4 complex was synthesized and used to obtain these parameters. Treatment of mice with 1 mumol of this complex revealed that 67Cu was distributed to blood, liver, kidney, intestine, lung, thymus, femur, muscle, spleen, brain, urine, and feces within 0.5 hr and patterned changes in 67Cu content of these tissues and excreta were found throughout the 96 hr term of this study.

    Topics: Animals; Biological Availability; Chemical Phenomena; Chemistry; Chronic Disease; Copper; Mice; Organ Specificity; Salicylates

1989