copper-bis(3-5-diisopropylsalicylate) and Cell-Transformation--Neoplastic

copper-bis(3-5-diisopropylsalicylate) has been researched along with Cell-Transformation--Neoplastic* in 1 studies

Other Studies

1 other study(ies) available for copper-bis(3-5-diisopropylsalicylate) and Cell-Transformation--Neoplastic

Article	Year
Role of free radicals in the initiation and promotion of radiation transformation in vitro. Carcinogenesis, 1984, Volume: 5, Issue:10 We have studied the effects of superoxide dismutase (SOD), catalase, Cu(II) (3,5-diisopropylsalicylate)2 (CuDIPS) and other copper compounds on radiation transformation in vitro using C3H 10T1/2 cells. When present only during irradiation, high concentrations of SOD in the medium enhanced transformation, while catalase, inactivated SOD (autoclaved), CuDIPS, cupric chloride and cuprous chloride inhibited the initiation phase of radiation transformation. SOD, catalase and CuDIPS did not affect the expression phase of radiation transformation. Suppression of the TPA enhancement of transformation by catalase was a highly significant effect, while the suppression by SOD was not of statistical significance. Our results suggest that hydrogen peroxide (H2O2) may be important in the cellular damage leading to malignant transformation. Topics: Animals; Catalase; Cell Transformation, Neoplastic; Free Radicals; Hydrogen Peroxide; Mice; Salicylates; Superoxide Dismutase; Tetradecanoylphorbol Acetate	1984

Article

Year

Role of free radicals in the initiation and promotion of radiation transformation in vitro.

Carcinogenesis, 1984, Volume: 5, Issue:10

We have studied the effects of superoxide dismutase (SOD), catalase, Cu(II) (3,5-diisopropylsalicylate)2 (CuDIPS) and other copper compounds on radiation transformation in vitro using C3H 10T1/2 cells. When present only during irradiation, high concentrations of SOD in the medium enhanced transformation, while catalase, inactivated SOD (autoclaved), CuDIPS, cupric chloride and cuprous chloride inhibited the initiation phase of radiation transformation. SOD, catalase and CuDIPS did not affect the expression phase of radiation transformation. Suppression of the TPA enhancement of transformation by catalase was a highly significant effect, while the suppression by SOD was not of statistical significance. Our results suggest that hydrogen peroxide (H2O2) may be important in the cellular damage leading to malignant transformation.

Topics: Animals; Catalase; Cell Transformation, Neoplastic; Free Radicals; Hydrogen Peroxide; Mice; Salicylates; Superoxide Dismutase; Tetradecanoylphorbol Acetate

1984