copiamycin has been researched along with Disease-Models--Animal* in 1 studies
1 other study(ies) available for copiamycin and Disease-Models--Animal
| Article | Year |
|---|---|
Inhibitory effects of copiamycin A, a macrocyclic lactone antibiotic, on gastric H+,K(+)-ATPase, acid secretion and ulcer formation.
When 17 macrocyclic lactone antibiotics were examined for their abilities to inhibit gastric H+,K(+)-ATPase, copiamycin A was found to have the strongest and relatively specific activity with IC50s of 15.7 micrograms/ml and greater than 100 micrograms/ml against the hog gastric H+,K(+)-ATPase and the dog kidney Na+,K(+)-ATPase, respectively. Furthermore, this antibiotic inhibited the histamine-induced gastric acid secretion in the isolated gastric mucosal membrane of guinea pigs and the gastric ulcer formation in pylorus-ligated rats. Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Disease Models, Animal; Dogs; Gastric Acid; Gastric Mucosa; Guinea Pigs; H(+)-K(+)-Exchanging ATPase; Kidney; Lactones; Pylorus; Rats; Rats, Inbred Strains; Sodium-Potassium-Exchanging ATPase; Stomach Ulcer; Swine | 1991 |