convallatoxin and Myocardial-Infarction

In experiments in nembutal anesthetized dogs the authors studied the dependence between the antifibrillation activity of propranolol, which was appraised according to the value of the ventricular fibrillation thresholds and the rate of spontaneous fibrillation after occlusion of the coronary artery, and the cardiodepressive and hypotensive action of this agent. It is shown that it is possible in principle to preserve the antifibrillation activity of propranolol infused intravenously in a dose of 1 mg/kg for correcting its cardiodepressive and hypotensive effect in combined intravenous infusion of 0.02 mg/kg corglycon. It is concluded that there is no dependence between antifibrillation activity and the cardiodepressive and hypotensive effects of propranolol.

Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Cardiac Glycosides; Depression, Chemical; Dogs; Drug Evaluation, Preclinical; Drug Therapy, Combination; Myocardial Contraction; Myocardial Infarction; Propranolol; Strophanthins; Ventricular Fibrillation