contraceptives--postcoital and Mitochondrial-Diseases

contraceptives--postcoital has been researched along with Mitochondrial-Diseases* in 1 studies

Other Studies

1 other study(ies) available for contraceptives--postcoital and Mitochondrial-Diseases

Article	Year
Butin reduces oxidative stress-induced mitochondrial dysfunction via scavenging of reactive oxygen species. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2010, Volume: 48, Issue:3 This study investigated the cytoprotective effect of butin, a flavonoid, on hydrogen peroxide (H(2)O(2))-induced mitochondrial dysfunction. Electron spin resonance (ESR) spectrometry revealed butin's significant scavenging effects on superoxide radicals and hydroxyl radicals. When H(2)O(2) was used to induce an increase in mitochondrial reactive oxygen species (ROS) in Chinese hamster lung fibroblast (V79-4) cells, butin treatment decreased high level of ROS. Butin also attenuated intracellular Ca(2+) levels that have been induced by H(2)O(2). Furthermore, butin recovered ATP levels and succinate dehydrogenase activity that had been decreased by H(2)O(2) treatment. We conclude these results suggest butin decreased mitochondrial ROS accumulation, balanced intracellular Ca(2+) levels, and improved mitochondrial energy production, thus recovering mitochondrial function. Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cell-Free System; CHO Cells; Contraceptives, Postcoital; Cricetinae; Cricetulus; Free Radical Scavengers; Hydroxyl Radical; Mitochondrial Diseases; Oxidative Stress; Reactive Oxygen Species; Succinate Dehydrogenase; Superoxides	2010

Article

Year

Butin reduces oxidative stress-induced mitochondrial dysfunction via scavenging of reactive oxygen species.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2010, Volume: 48, Issue:3

This study investigated the cytoprotective effect of butin, a flavonoid, on hydrogen peroxide (H(2)O(2))-induced mitochondrial dysfunction. Electron spin resonance (ESR) spectrometry revealed butin's significant scavenging effects on superoxide radicals and hydroxyl radicals. When H(2)O(2) was used to induce an increase in mitochondrial reactive oxygen species (ROS) in Chinese hamster lung fibroblast (V79-4) cells, butin treatment decreased high level of ROS. Butin also attenuated intracellular Ca(2+) levels that have been induced by H(2)O(2). Furthermore, butin recovered ATP levels and succinate dehydrogenase activity that had been decreased by H(2)O(2) treatment. We conclude these results suggest butin decreased mitochondrial ROS accumulation, balanced intracellular Ca(2+) levels, and improved mitochondrial energy production, thus recovering mitochondrial function.

Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cell-Free System; CHO Cells; Contraceptives, Postcoital; Cricetinae; Cricetulus; Free Radical Scavengers; Hydroxyl Radical; Mitochondrial Diseases; Oxidative Stress; Reactive Oxygen Species; Succinate Dehydrogenase; Superoxides

2010