coniferyl-alcohol and Leukemia--Basophilic--Acute

coniferyl-alcohol has been researched along with Leukemia--Basophilic--Acute* in 1 studies

Other Studies

1 other study(ies) available for coniferyl-alcohol and Leukemia--Basophilic--Acute

Article	Year
1'-Hydroxyeugenol- and coniferyl alcohol derivatives as effective inhibitors of 5-lipoxygenase and Cu(2+)-mediated low density lipoprotein oxidation. Evidence for a dual mechanism. Arzneimittel-Forschung, 1994, Volume: 44, Issue:8 1'-Hydroxyeugenol- and epoxy-Z-coniferyl alcohol esters from Coreopsis species as well as synthetic derivatives of these natural compounds were examined as lipoxygenase inhibitors and as LDL (low density lipoprotein)-stabilizing agents. Most of the compounds displayed inhibitory activity on the formation of leukotrienes (LTB4 and LTC4) in a cellular (RBL-1 cells) assay as well as in a cell-free 5-lipoxygenase assay at concentrations of 4-24 mumol/l. No effect of selected compounds was observed on mammalian lipoxygenases with other specificity (12- and 15-lipoxygenase). The more lipophilic derivatives also effectively reduced Cu(2+)-mediated oxidation of LDL. The findings are discussed on the base of structure-activity relationships. Topics: Animals; Arachidonate 12-Lipoxygenase; Arachidonate 15-Lipoxygenase; Arachidonate 5-Lipoxygenase; Copper; Eugenol; Humans; Leukemia, Basophilic, Acute; Leukotriene B4; Leukotriene C4; Lipoproteins; Lipoxygenase Inhibitors; Oxidation-Reduction; Phenols; Rats; Structure-Activity Relationship; Tumor Cells, Cultured	1994

Article

Year

1'-Hydroxyeugenol- and coniferyl alcohol derivatives as effective inhibitors of 5-lipoxygenase and Cu(2+)-mediated low density lipoprotein oxidation. Evidence for a dual mechanism.

Arzneimittel-Forschung, 1994, Volume: 44, Issue:8

1'-Hydroxyeugenol- and epoxy-Z-coniferyl alcohol esters from Coreopsis species as well as synthetic derivatives of these natural compounds were examined as lipoxygenase inhibitors and as LDL (low density lipoprotein)-stabilizing agents. Most of the compounds displayed inhibitory activity on the formation of leukotrienes (LTB4 and LTC4) in a cellular (RBL-1 cells) assay as well as in a cell-free 5-lipoxygenase assay at concentrations of 4-24 mumol/l. No effect of selected compounds was observed on mammalian lipoxygenases with other specificity (12- and 15-lipoxygenase). The more lipophilic derivatives also effectively reduced Cu(2+)-mediated oxidation of LDL. The findings are discussed on the base of structure-activity relationships.

Topics: Animals; Arachidonate 12-Lipoxygenase; Arachidonate 15-Lipoxygenase; Arachidonate 5-Lipoxygenase; Copper; Eugenol; Humans; Leukemia, Basophilic, Acute; Leukotriene B4; Leukotriene C4; Lipoproteins; Lipoxygenase Inhibitors; Oxidation-Reduction; Phenols; Rats; Structure-Activity Relationship; Tumor Cells, Cultured

1994