conidendrin has been researched along with Colonic-Neoplasms* in 1 studies
1 other study(ies) available for conidendrin and Colonic-Neoplasms
| Article | Year |
|---|---|
Three new C-14 oxygenated taxanes from the wood of Taxus yunnanensis.
Three new C-14 oxygenated taxane-type diterpenes, hongdoushans A-C (1-3), were isolated from the wood of Taxus yunnanensis together with four known diterpenes and two lignans. The absolute stereochemistry of the 2-methylbutyryloxy group attached at C-14 of the taxane skeleton was determined to be S by GC analysis of the methyl ester of 2-methylbutyric acid obtained after alkaline hydrolysis of 1 and 4 followed by treatment with CH(2)N(2). The complete stereostructure of the known compound 2alpha,5alpha,10beta-triacetoxy-14beta-[(S)-2-methylbutyryloxy]-4(20),11-taxadiene (4) was established for the first time. The isolates obtained were evaluated for their antiproliferative activity toward murine colon 26-L5 carcinoma and human HT-1080 fibrosarcoma cell lines. Topics: Animals; Antineoplastic Agents, Phytogenic; Bridged-Ring Compounds; Cell Survival; Colonic Neoplasms; Diterpenes; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Fibrosarcoma; Humans; Hydrolysis; Mice; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Paclitaxel; Plants, Medicinal; Stereoisomerism; Taxoids; Taxus; Trees; Tumor Cells, Cultured | 2002 |