congo red has been researched along with Acute Confusional Senile Dementia in 124 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 15 (12.10) | 18.7374 |
1990's | 20 (16.13) | 18.2507 |
2000's | 50 (40.32) | 29.6817 |
2010's | 33 (26.61) | 24.3611 |
2020's | 6 (4.84) | 2.80 |
Authors | Studies |
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Anguiano, M; Cho, CG; Han, H; Lansbury, PT; Lemere, CA; Zhen, W | 1 |
Kim, DS; Park, SY | 1 |
Arano, Y; Haratake, M; Ishibashi, K; Mori, H; Nakayama, M; Ono, M; Yoshida, N | 1 |
Glabe, CG; Kayed, R; Milton, S; Necula, M | 1 |
Haratake, M; Hori, M; Mori, H; Nakayama, M; Ono, M; Tomiyama, T | 1 |
Chae, BS; Eun, JS; Kim, DK; Kim, KH; Kwon, YE; Lee, SK; Leem, JY; No, KT; Park, JY; Shin, JH; Shin, TY; Yang, JH | 1 |
Haratake, M; Mori, H; Nakayama, M; Ono, M | 1 |
Andrisano, V; Banzi, R; Bartolini, M; Bergamini, C; Bolognesi, ML; Cattaneo, A; Cavalli, A; Fato, R; Hrelia, P; Lenaz, G; Melchiorre, C; Minarini, A; Recanatini, M; Rosini, M; Tarozzi, A; Tumiatti, V | 1 |
Cui, MC; Duan, XH; Liu, BL; Qiao, JP; Yang, Y; Zhou, JN | 1 |
Chen, ZF; Huang, SL; Huang, ZS; Liang, H; Qin, JK; Tang, H; Zhao, HT; Zhao, LZ; Zhong, SM | 1 |
Chen, ZF; Liang, H; Tang, H; Wang, ZY; Zhao, HT; Zhong, SM | 1 |
Chao, X; Cheng, Z; He, X; Huang, Y; Jin, M; Liu, P; Liu, S; Pi, R; Qin, J; Rapposelli, S; Tan, Y; Wang, Y; Yang, Y; Yu, J; Zhou, X | 1 |
Chen, SB; Gu, LQ; He, Y; Huang, SL; Huang, ZH; Huang, ZS; Li, D; Tan, JH; Yao, PF | 1 |
Chen, Z; Chu, J; Digiacomo, M; Han, Y; Lapucci, A; Macchia, M; Pi, R; Rapposelli, S; Wang, S; Yang, X | 1 |
Chen, J; Chen, Q; Chen, Z; Chu, J; Digiacomo, M; Gu, Q; Han, Y; Macchia, M; Nesi, G; Pi, R; Rapposelli, S; Sestito, S; Tu, Y; Wang, S; Yang, X | 1 |
Benderitter, P; Froestl, W; Hamel, A; Hickman, DT; Kroth, H; Muhs, A; Pfeifer, A; Sreenivasachary, N; Varisco, Y | 1 |
Guo, QL; Huang, SL; Huang, ZS; Li, D; Liu, ZQ; Ou, TM; Tan, JH; Wang, HG; Wang, N; Wu, JQ; Xia, CL | 1 |
Ann, J; Choi, K; Ha, HJ; Hong, HS; Hyun, HJ; Jo, DG; Kang, DW; Kang, JM; Kim, H; Kim, HM; Kim, SH; Kim, Y; Lee, J; Lee, JH | 1 |
Gupta, S; Kumar, S; Modi, G; Rai, H; Ran, C; Singh, SK; Yang, J | 1 |
Beladiya, J; Modi, K; Pande, S; Parmar, S; Patel, B; Patel, C; Patel, S; Shah, S; Sheth, D; Vyas, A | 1 |
Kanagasingam, S; Singhrao, SK; von Ruhland, C; Welbury, R | 1 |
Amiri, I; Ghanbari, A; Gholami Mahmoudian, Z; Komaki, A; Rashidi, I | 1 |
Cuevas, E; Hanig, J; Raymick, J; Rosas-Hernandez, H; Sarkar, S | 1 |
Hanig, J; Raymick, J; Sarkar, S; Setti, SE | 1 |
Cui, M; Fu, H | 1 |
Emami, S; Hosseinimehr, SJ; Molavipordanjani, S | 1 |
del Valle, E; Mártínez, E; Navarro, A; Ordóñez, C; Pérez, C; Tolivia, J | 1 |
Jackson, DR; McKnight, RE; Yokoyama, K | 1 |
Li, M; Qu, X; Ren, J; Wang, E; Wu, L; Xu, C | 1 |
Diao, XW; Fa, HB; Li, S; Yin, W; Zhang, D; Zhou, JT | 1 |
Dai, F; Fan, Z; Hu, B; Ma, G; Tang, Q; Zhang, X | 1 |
Adams, DL; Stefansson, S; Tang, CM | 1 |
Ait-Ghezala, G; Ganey, C; Ganey, N; Laporte, V; Mullan, M; Volmar, CH; Wood, M | 1 |
Levine, H; Walker, LC | 1 |
Baldwin, A; Collingwood, J; Exley, C; Goodwin, S; House, E; Mold, M | 1 |
Archimandritis, S; Georgoulias, P; Papatriantafyllou, J; Sifakis, N; Valotassiou, V | 1 |
Adipepe, LF; Baloyannis, SJ; Costa, VG; Fotiou, DF; Manani, MG; Mavroudis, IA; Njau, SD; Psaroulis, D | 1 |
Cui, W; Feng, XY; Gu, B; He, H; Li, J; Li, S; Liang, CM; Qi, Z; Zhou, G | 1 |
Fang, CL; Hu, J; Lei, P; Li, RW; Li, YM; Liu, P; Liu, Q; Sun, X; Wu, WH; Zhao, YF; Zheng, YZ | 1 |
Gestwicki, JE; Reinke, AA | 1 |
Esmailzade, B; Hoseini, SM; Mortazavi, P; Nobakht, M; Omidzahir, S; Rahbar Rooshandel, N; Sohrabi, I | 1 |
Aiso, S; Chiba, T; Hayashi, K; Sasabe, J; Utsunomiya-Tate, N | 1 |
Bär, KJ; Ferszt, R; Gertz, HJ; Juckel, G; Mavrogiorgou, P; Wolf, R | 1 |
Akaike, A; Irie, K; Izumi, Y; Izuo, N; Kume, T; Murakami, K; Sato, M | 1 |
Beauquis, J; Galvan, V; Pavía, P; Podlutskaya, N; Pomilio, C; Saravia, F; Vinuesa, A | 1 |
Jaggi, AS; Sharma, B; Singh, B; Singh, N | 1 |
Dzyuba, SV; Jameson, LP; Smith, NW | 1 |
Dehvari, K; Lin, KS | 1 |
de Ronde, FM; Dijkstra, J; Hegeman-Kleinn, I; Nabuurs, RJ; Natté, R; Rozemuller, AJ; van Buchem, MA; van der Weerd, L; van Duinen, SG; Webb, AG | 1 |
Bacskai, BJ; Debnath, ML; Frosch, MP; Holt, DP; Hyman, BT; Kajdasz, ST; Klunk, WE; Mathis, CA; McLellan, ME; Wang, Y | 1 |
Abe, K; Harigaya, Y; Ikeda, M; Kawarabayashi, T; Matsubara, E; Naito, M; Nakazato, Y; Sasaki, A; Shoji, M | 1 |
Cottingham, MG; Hollinshead, MS; Vaux, DJ | 1 |
Wang, L; Xu, D; Yang, C | 1 |
Hartsel, SC; Weiland, TR | 1 |
Ashur-Fabian, O; Brenneman, DE; Giladi, E; Gozes, I; Segal-Ruder, Y; Skutelsky, E; Steingart, RA | 1 |
Di Carlo, G; Gordon, MN; Mori, S; Munireddy, S; van Zijl, PC; Yarowsky, P; Zhang, J | 1 |
Iwai, A; Kawabata, S; Noda-Saita, K; Okada, M; Shitaka, Y; Terai, K; Tsukamoto, M; Yamaguchi, T | 1 |
Crabtree, GR; Gestwicki, JE; Graef, IA | 1 |
Corder, EH; Galeazzi, L; Galeazzi, R; Giunta, S; Valli, MB | 1 |
Ambegaokar, SS; Begum, AN; Chen, PP; Cole, GM; Frautschy, SA; Glabe, CG; Kayed, R; Lim, GP; Simmons, MR; Ubeda, OJ; Yang, F | 1 |
Cechetto, DF; Hachinski, VC; Whitehead, SN | 1 |
Inouye, H; Kirschner, DA | 1 |
Kelly, JW | 1 |
Carson, K; Good, T; Lee, S; Rice-Ficht, A | 1 |
Crowther, DC; Curry, JA; Duthie, FA; Gubb, DC; Kinghorn, KJ; Lomas, DA; Miranda, E; Page, R | 1 |
Brown, J; Gee, AD; Hong, G; Lockhart, A; Morgenstern, JL; Ye, L | 1 |
Bose, M; Crabtree, GR; Devasthali, V; Gestwicki, JE; Graef, IA | 1 |
LeVine, H | 1 |
Akagi, T; Chui, DH; Fukuda, T; Hashikawa, T; Kimura, T; Kudo, T; Miyasaka, T; Murayama, M; Nakano, Y; Park, JM; Takashima, A; Takeda, M; Tanemura, K; Tatebayashi, Y | 1 |
Gruys, E; Rofina, JE; Secrève, M; Toussaint, MJ; van der Meer, I; van der Spek, A; van Ederen, AM; Van Eerdenburg, FJ | 1 |
Konermann, S; Nafe, R; Swaab, DF; van de Nes, JA | 1 |
Ono, M | 1 |
Gordon, MN; Morgan, D; Wilcock, DM | 1 |
Bandyopadhyay, B; Kuret, J; Li, G; Yin, H | 1 |
Byun, HR; Cho, E; Han, PL; Kim, DH; Kim, YH; Koh, JY; Kweon, HS; Lee, JY | 1 |
Cheng, RH; Hong, HS; Jin, LW; Kung, HF; Kung, MP; Laferla, FM; Lam, KS; Liu, R; Maezawa, I; Oddo, S; Wu, CY | 1 |
Bozon, B; Delatour, B; Delzescaux, T; Dhenain, M; Dubois, A; Faure, A; Feki, A; Hantraye, P; Teboul, O | 1 |
Chander, H; Chauhan, A; Chauhan, V | 1 |
Glenner, GG | 2 |
Fujihara, S; Glenner, GG; Henry, JH | 1 |
Bignami, A; Dahl, D; Selkoe, DJ | 1 |
Baum, L; Flowers, D; Halliday, G | 1 |
Castano, EM; Frangione, B; Golabek, A; Kumar, RA; Prelli, F; Soto, C; Wisniewski, T | 1 |
Frangione, B; Golabek, AA; Kida, E; Wisniewski, KE; Wisniewski, T | 1 |
Iwai, A; Masliah, E; Saitoh, T; Yoshimoto, M | 1 |
Bots, GT; Eikelenboom, P; Kamphorst, W; Roos, RA; Rozemuller, AJ; Van Nostrand, WE | 1 |
Alvarez, RB; Askanas, V; Engel, WK | 1 |
Lorenzo, A; Yankner, BA | 1 |
Hurle, MR; MacKenzie, L; Maleeff, B; Wetzel, R; Wood, SJ | 1 |
Chan, W; Wetzel, R; Wood, SJ | 1 |
Liljeström, M; Maury, CP; Nurmiaho-Lassila, EL | 1 |
de Waal, RM; Eikelenboom, P; Verbeek, MM | 1 |
Colvin, RA; Derrico, CA; Hatem, L; Wu, A | 1 |
Choo-Smith, LP; Garzon-Rodriguez, W; Glabe, CG; Surewicz, WK | 1 |
Kitamoto, T; Kondo, A; Ogino, K; Saido, TC; Shin, RW; Tateishi, J; Trojanowski, JQ | 1 |
Emmerling, MR; Spiegel, K; Watson, MD | 1 |
Debnath, ML; Klunk, WE; Koros, AM; Pettegrew, JW | 1 |
Castillo, GM; Lukito, W; Snow, AD; Wight, TN | 1 |
Brining, SK; Chen, N; Chrambach, A; Yi, D | 1 |
Bian, F; Callahan, MJ; Durham, RA; Kane, MD; Lipinski, WJ; Roher, AE; Schwarz, RD; Walker, LC | 1 |
Hatters, DM; Howlett, GJ; Lawrence, LJ; MacPhee, CE; Sawyer, WH | 1 |
Serpell, LC | 1 |
Findeis, MA | 1 |
Hamilton, RL; Klunk, WE; Styren, GC; Styren, SD | 1 |
Bates, GP; Cooper, GJ; Faull, RL; Holloway, H; Mangiarini, L; McGowan, DP; Snell, RG; van Roon-Mom, W | 1 |
Higuchi, M; Ishihara, T; Lee, VM; Trojanowski, JQ; Yoshiyama, Y; Zhang, B | 1 |
Bales, KR; DiCarlo, G; Gordon, MN; Morgan, D; Nilsson, LN; Paul, SM; Potter, H | 1 |
Fan, QW; Gong, JS; Michikawa, M; Sawamura, N; Yanagisawa, K | 1 |
Mallory, M; Mante, M; Masliaha, E; Rockenstein, E; Sisk, A | 1 |
Boyett, KW; Connor, KE; DiCarlo, G; Dickey, C; Gordon, MN; Gottschall, PE; Hardy, J; Jantzen, PT; Melachrino, J; Morgan, D; Ugen, KE; Wilcock, DM | 1 |
Guimard, NK; Hecht, MH; Wurth, C | 1 |
Hirai, S; Morimatsu, M; Muramatsu, A; Yoshikawa, M | 1 |
Ali-Khan, Z; Alizadeh-Khiavi, K; Chronopoulos, S; Normand, J | 1 |
Fink, G; Hussey, S; Yates, CM | 1 |
Kitamoto, T; Sato, Y; Tashima, T; Tateishi, J | 1 |
Defossez, A; Delacourte, A; Peers, MC; Persuy, P | 1 |
Allsop, D; Glenner, GG; Ikeda, S | 1 |
Mar, H; Nochlin, D; Snow, AD; Wight, TN | 1 |
Hassell, J; Kato, M; Kimata, K; Mar, H; Nochlin, D; Snow, AD; Suzuki, S; Wight, TN | 1 |
Bennett-Gray, J; Goeken, JA; Hart, MN; Menezes, AH; Merz, P; Schelper, RL; Wisniewski, HM | 1 |
Haider, A; Rosenblum, WI | 1 |
Esiri, MM; Wilcock, GK | 1 |
Gibson, PH | 1 |
14 review(s) available for congo red and Acute Confusional Senile Dementia
Article | Year |
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Near-Infrared Fluorescent Probes as Imaging and Theranostic Modalities for Amyloid-Beta and Tau Aggregates in Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Fluorescent Dyes; Humans; Precision Medicine; tau Proteins | 2022 |
Fluorescent Imaging of Amyloid-β Deposits in Brain: An Overview of Probe Development and a Highlight of the Applications for In Vivo Imaging.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Congo Red; Curcumin; Fluorescent Dyes; Humans; Microscopy, Fluorescence, Multiphoton; Positron Emission Tomography Computed Tomography; Thiazoles | 2018 |
99mTc-labeled Small Molecules for Diagnosis of Alzheimer's Disease: Past, Recent and Future Perspectives.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Blood-Brain Barrier; Congo Red; Curcumin; Humans; Organotechnetium Compounds; Small Molecule Libraries; Tomography, Emission-Computed, Single-Photon | 2019 |
Insight into amyloid structure using chemical probes.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Animals; Benzothiazoles; Coloring Agents; Congo Red; Humans; Molecular Sequence Data; Protein Conformation; Thiazoles | 2011 |
Dye-binding assays for evaluation of the effects of small molecule inhibitors on amyloid (aβ) self-assembly.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Coloring Agents; Congo Red; Drug Discovery; False Positive Reactions; Fluorescent Dyes; Humans; Reproducibility of Results; Thiazoles | 2012 |
Alzheimer's beta-amyloid: insights into fibril formation and structure from Congo red binding.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Coloring Agents; Congo Red; Humans; Kinetics; Molecular Sequence Data; Peptide Fragments; Protein Binding | 2005 |
'Nature-inspired' drug-protein complexes as inhibitors of Abeta aggregation.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Congo Red; Humans; Multiprotein Complexes; Nerve Degeneration; Tacrolimus Binding Proteins | 2005 |
[Molecular imaging of beta-amyloid plaques in the brain].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Benzothiazoles; Brain; Congo Red; Humans; Mice; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles; Tomography, Emission-Computed, Single-Photon | 2007 |
The bases of the staining of amyloid fibers: their physico-chemical nature and the mechanism of their dye-substrate interaction.
Topics: Alzheimer Disease; Amino Acids; Amyloid; Amyloidosis; Coloring Agents; Congo Red; Fluorescent Antibody Technique; Gentian Violet; Humans; Immunoglobulins; Iodine; Microscopy, Electron; Organoids; Periodic Acid; Protein Conformation; Serum Amyloid A Protein; Staining and Labeling | 1981 |
Distribution of beta/A4 protein and amyloid precursor protein in hereditary cerebral hemorrhage with amyloidosis-Dutch type and Alzheimer's disease.
Topics: Adult; Aged; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloidosis; Brain; Cerebral Hemorrhage; Congo Red; Female; Humans; Immunohistochemistry; Male; Middle Aged; Neurites; Staining and Labeling; Tissue Distribution | 1993 |
Amyloid fibril toxicity in Alzheimer's disease and diabetes.
Topics: Alzheimer Disease; Amyloid; Animals; Cats; Cells, Cultured; Congo Red; Diabetes Mellitus; Hippocampus; Humans; Islet Amyloid Polypeptide; Islets of Langerhans; Nerve Degeneration; Neurons; Rats; Solubility; Synapses | 1996 |
Differences between the pathogenesis of senile plaques and congophilic angiopathy in Alzheimer disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Brain; Congo Red; Humans; Immunohistochemistry | 1997 |
Alzheimer's amyloid fibrils: structure and assembly.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Congo Red; Humans; Microscopy, Atomic Force; Molecular Structure; Neurons; Peptide Fragments; Plaque, Amyloid; Protein Conformation; Protein Structure, Secondary; Solubility; X-Ray Diffraction | 2000 |
Approaches to discovery and characterization of inhibitors of amyloid beta-peptide polymerization.
Topics: Acridines; Alzheimer Disease; Amyloid beta-Peptides; Benzofurans; Congo Red; Doxorubicin; Drug Design; Humans; Molecular Structure; Neurofibrillary Tangles; Peptide Fragments; Polymers; Protein Binding; Rifampin | 2000 |
110 other study(ies) available for congo red and Acute Confusional Senile Dementia
Article | Year |
---|---|
Synthesis and amyloid binding properties of rhenium complexes: preliminary progress toward a reagent for SPECT imaging of Alzheimer's disease brain.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cerebral Cortex; Coloring Agents; Congo Red; Humans; In Vitro Techniques; Organometallic Compounds; Organotechnetium Compounds; Peptide Fragments; Radiopharmaceuticals; Rhenium; Staining and Labeling; Tomography, Emission-Computed, Single-Photon | 1999 |
Discovery of natural products from Curcuma longa that protect cells from beta-amyloid insult: a drug discovery effort against Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Biological Products; Cell Survival; Cinnamates; Curcuma; Curcumin; Diarylheptanoids; Diterpenes; Molecular Structure; Monoterpenes; PC12 Cells; Peptide Fragments; Plants, Medicinal; Rats | 2002 |
Radioiodinated flavones for in vivo imaging of beta-amyloid plaques in the brain.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Animals; Binding Sites; Brain; Flavones; Humans; Iodine Radioisotopes; Isotope Labeling; Mice; Peptide Fragments; Plaque, Amyloid; Protein Binding; Radiopharmaceuticals; Solutions; Structure-Activity Relationship; Tissue Distribution; Tomography, Emission-Computed, Single-Photon | 2005 |
Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Humans; Plaque, Amyloid; Protein Structure, Quaternary; Thermodynamics | 2007 |
Structure-activity relationship of chalcones and related derivatives as ligands for detecting of beta-amyloid plaques in the brain.
Topics: Alzheimer Disease; Animals; Binding, Competitive; Brain; Chalcones; Disease Models, Animal; Ligands; Mice; Plaque, Amyloid; Structure-Activity Relationship | 2007 |
Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abeta1-42 aggregation for Alzheimer's disease therapeutics.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Butyrylcholinesterase; Cell Line; Cell Survival; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Models, Molecular; Molecular Structure; Peptide Fragments; Piperidines; Protein Structure, Tertiary; Structure-Activity Relationship | 2007 |
Novel chalcones as probes for in vivo imaging of beta-amyloid plaques in Alzheimer's brains.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Chalcones; Iodine Radioisotopes; Mice; Mice, Transgenic; Molecular Probes; Plaque, Amyloid; Solutions | 2007 |
Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Binding Sites; Butyrylcholinesterase; Cell Line; Cholinesterase Inhibitors; Humans; Ligands; Models, Molecular; NAD(P)H Dehydrogenase (Quinone); Oxidative Stress; Polyamines; Protein Binding; Quinones; Reactive Oxygen Species; Structure-Activity Relationship; Substrate Specificity | 2007 |
Novel anilinophthalimide derivatives as potential probes for beta-amyloid plaque in the brain.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Brain; Humans; Mice; Phthalimides; Tomography, Emission-Computed, Single-Photon | 2010 |
Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Aporphines; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Electrophorus; Horses; Humans; Models, Biological; Tacrine | 2011 |
Novel oxoisoaporphine-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Aporphines; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Humans; Membranes, Artificial; Models, Molecular; Molecular Structure; Permeability; Protein Binding | 2012 |
Design, synthesis and pharmacological evaluation of novel tacrine-caffeic acid hybrids as multi-targeted compounds against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Butyrylcholinesterase; Caffeic Acids; Cell Death; Cell Line; Cholinesterase Inhibitors; Drug Design; Hydrogen Peroxide; Mice; Neurons; Neuroprotective Agents; Tacrine | 2012 |
Synthesis and evaluation of 7,8-dehydrorutaecarpine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Biocatalysis; Butyrylcholinesterase; Cell Line, Tumor; Cell Survival; Chelating Agents; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Indole Alkaloids; Inhibitory Concentration 50; Kinetics; Models, Chemical; Models, Molecular; Molecular Structure; Peptide Fragments; Protein Binding; Protein Structure, Tertiary; Quinazolines | 2013 |
Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Caffeic Acids; Cell Line; Cholinesterase Inhibitors; Coumaric Acids; Drug Design; Humans; Models, Molecular; Structure-Activity Relationship; Tacrine; Thioctic Acid | 2015 |
Discovery of novel rivastigmine-hydroxycinnamic acid hybrids as multi-targeted agents for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Cholinesterase Inhibitors; Coumaric Acids; Drug Discovery; Humans; In Vitro Techniques; Neuroprotective Agents; Rivastigmine; Structure-Activity Relationship | 2017 |
Discovery and characterization of novel indole and 7-azaindole derivatives as inhibitors of β-amyloid-42 aggregation for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Drug Discovery; Humans; Indoles; Liver; Male; Mice; Peptide Fragments | 2017 |
Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Blood-Brain Barrier; Cell Death; Cell Line; Cholinesterase Inhibitors; Drug Design; Glutathione; Humans; Quinolines; Reactive Oxygen Species | 2017 |
Discovery of an Orally Bioavailable Benzofuran Analogue That Serves as a β-Amyloid Aggregation Inhibitor for the Potential Treatment of Alzheimer's Disease.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzofurans; Biological Availability; Cell Line; Dogs; Humans; Mice; Protein Aggregates; Rats | 2018 |
Amelioration of intracerebroventricular streptozotocin-induced cognitive dysfunction by Ocimum sanctum L. through the modulation of inflammation and GLP-1 levels.
Topics: Alzheimer Disease; Animals; Cognitive Dysfunction; Congo Red; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Glucagon-Like Peptide 1; Inflammation; Male; Maze Learning; Memory Disorders; Ocimum sanctum; Plant Extracts; Rats; Rats, Wistar; Streptozocin; Tumor Necrosis Factor-alpha | 2022 |
Antimicrobial, Polarizing Light, and Paired Helical Filament Properties of Fragmented Tau Peptides of Selected Putative Gingipains.
Topics: Alzheimer Disease; Anti-Infective Agents; Congo Red; Gingipain Cysteine Endopeptidases; Humans; Neurofibrillary Tangles; Peptides; Phosphorylation; tau Proteins | 2022 |
The effect of minocycline on beta-amyloid-induced memory and learning deficit in male rats: A behavioral, biochemical, and histological study.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Antioxidants; Avoidance Learning; Congo Red; Disease Models, Animal; Hippocampus; Male; Minocycline; Peptide Fragments; Plaque, Amyloid; Rats | 2022 |
Modification of methods to use Congo-red stain to simultaneously visualize amyloid plaques and tangles in human and rodent brain tissue sections.
Topics: Alzheimer Disease; Animals; Brain; Brain Chemistry; Coloring Agents; Congo Red; Humans; Mice; Mice, Transgenic; Neurofibrillary Tangles; Optical Imaging; Plaque, Amyloid; Rats; Rodentia; Staining and Labeling | 2020 |
In vivo demonstration of Congo Red labeled amyloid plaques via perfusion in the Alzheimer disease rat model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Congo Red; Perfusion; Plaque, Amyloid; Rats | 2021 |
Highly selective and fast diagnosis of Alzheimer's disease hallmark lesions using Congo Red in isopropyl alcoholic solution.
Topics: 2-Propanol; Aged; Alzheimer Disease; Amyloidosis; Blood Vessels; Brain; Cerebral Amyloid Angiopathy; Congo Red; Humans; Microscopy, Fluorescence; Neurofibrillary Tangles; Plaque, Amyloid; Solutions | 2013 |
Temperature dependence of Congo red binding to amyloid β12-28.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Buffers; Calorimetry; Circular Dichroism; Congo Red; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Models, Chemical; Peptide Fragments; Protein Binding; Protein Conformation; Temperature | 2013 |
Self-assembled peptide-polyoxometalate hybrid nanospheres: two in one enhances targeted inhibition of amyloid β-peptide aggregation associated with Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Death; Colloids; Congo Red; Kinetics; Mice; Microscopy, Fluorescence; Nanospheres; PC12 Cells; Protein Structure, Quaternary; Rats; Tungsten Compounds | 2013 |
The detection of β-amyloid plaques in an Alzheimer's disease rat model with DDNP-SPIO.
Topics: 2-Naphthylamine; Acrylonitrile; Alzheimer Disease; Animals; Case-Control Studies; Coloring Agents; Congo Red; Contrast Media; Disease Models, Animal; Ferrocyanides; Hippocampus; Magnetic Resonance Imaging; Magnetite Nanoparticles; Plaque, Amyloid; Rats; Spectrometry, Fluorescence | 2015 |
Nanotheranostics: Congo Red/Rutin-MNPs with Enhanced Magnetic Resonance Imaging and H2O2-Responsive Therapy of Alzheimer's Disease in APPswe/PS1dE9 Transgenic Mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Cell Line, Tumor; Congo Red; Contrast Media; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Drug Liberation; Ferric Compounds; Humans; Hydrogen Peroxide; Magnetic Resonance Imaging; Magnetite Nanoparticles; Mice, Transgenic; Neuroprotective Agents; Oxidative Stress; Plaque, Amyloid; Presenilin-1; Rutin; Theranostic Nanomedicine | 2015 |
Common benzothiazole and benzoxazole fluorescent DNA intercalators for studying Alzheimer Aβ1-42 and prion amyloid peptides.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Benzoxazoles; Congo Red; Fluorescent Dyes; Humans; Intercalating Agents; Peptide Fragments; Prions | 2012 |
CD40 ligation mediates plaque-associated tau phosphorylation in beta-amyloid overproducing mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; CD40 Antigens; CD40 Ligand; Cell Line, Tumor; Chromobox Protein Homolog 5; Coloring Agents; Congo Red; Cyclin-Dependent Kinase 5; Disease Models, Animal; Down-Regulation; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurites; Neurofibrillary Tangles; Phosphorylation; Phosphotransferases; Plaque, Amyloid; tau Proteins | 2008 |
Molecular polymorphism of Abeta in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Benzothiazoles; Binding Sites; Binding, Competitive; Coloring Agents; Congo Red; Diagnostic Imaging; Disease Models, Animal; Humans; Ligands; Molecular Probes; Pathology, Molecular; Plaque, Amyloid; Predictive Value of Tests; Protein Isoforms; Thiazoles | 2010 |
Copper abolishes the beta-sheet secondary structure of preformed amyloid fibrils of amyloid-beta(42).
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Birefringence; Congo Red; Copper; Fluorescent Dyes; Humans; Microscopy, Electron, Transmission; Peptide Fragments; Peptides; Protein Structure, Secondary; Thiazoles | 2009 |
Alzheimer's disease: spect and pet tracers for beta-amyloid imaging.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Brain Mapping; Cerebral Cortex; Congo Red; Fluorodeoxyglucose F18; Humans; Neurofibrillary Tangles; Positron-Emission Tomography; Protein Binding; Radiopharmaceuticals; Thiazoles; Tomography, Emission-Computed, Single-Photon | 2010 |
Morphological changes of the human purkinje cells and deposition of neuritic plaques and neurofibrillary tangles on the cerebellar cortex of Alzheimer's disease.
Topics: Alzheimer Disease; Cerebellar Cortex; Cerebral Cortex; Congo Red; Dendritic Spines; Hippocampus; Humans; Methenamine; Neurofibrillary Tangles; Plaque, Amyloid; Purkinje Cells; Silver Staining | 2010 |
Detection of Aβ plaques by a novel specific MRI probe precursor CR-BSA-(Gd-DTPA)n in APP/PS1 transgenic mice.
Topics: Albumins; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Congo Red; Contrast Media; Disease Models, Animal; Drug Combinations; Gadolinium DTPA; Immunohistochemistry; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Transgenic; Molecular Probes; Neurofibrillary Tangles; Plaque, Amyloid | 2010 |
Mapping ApoE/Aβ binding regions to guide inhibitor discovery.
Topics: Alkenes; Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Apolipoprotein E4; Apolipoproteins E; Benzoates; Binding Sites; Binding, Competitive; Congo Red; Drug Discovery; Humans; Molecular Sequence Data; Peptides; Protein Binding; Protein Interaction Domains and Motifs; Protein Interaction Mapping | 2011 |
Neuropathological changes in brain cortex and hippocampus in a rat model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Avoidance Learning; Cell Count; Cell Death; Cerebral Cortex; Congo Red; Disease Models, Animal; Hippocampus; In Situ Nick-End Labeling; Male; Maze Learning; Neurons; Rats; Rats, Wistar; Staining and Labeling | 2011 |
D-Ser-containing humanin shows promotion of fibril formation.
Topics: Alzheimer Disease; Amino Acid Sequence; Benzothiazoles; Circular Dichroism; Congo Red; Humans; Intracellular Signaling Peptides and Proteins; Molecular Sequence Data; Neuroprotective Agents; Protein Structure, Secondary; Solutions; Stereoisomerism; Structure-Activity Relationship; Thiazoles | 2012 |
Are routine methods good enough to stain senile plaques and neurofibrillary tangles in different brain regions of demented patients?
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Congo Red; Cryoultramicrotomy; Female; Humans; Male; Neurofibrillary Tangles; Paraffin Embedding; Plaque, Amyloid; Sensitivity and Specificity; Silver Staining; Staining and Labeling | 2011 |
Toxicity in rat primary neurons through the cellular oxidative stress induced by the turn formation at positions 22 and 23 of Aβ42.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blotting, Western; Cell Survival; Cells, Cultured; Chromans; Congo Red; Female; Free Radical Scavengers; Mutation; Neurons; Neurotoxins; Oxidative Stress; Peptide Fragments; Pregnancy; Protein Conformation; Rats; Rats, Wistar; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles; Vitamin E | 2012 |
Environmental enrichment prevents astroglial pathological changes in the hippocampus of APP transgenic mice, model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Astrocytes; Brain Chemistry; Coloring Agents; Congo Red; Disease Progression; Environment; Female; Glial Fibrillary Acidic Protein; Hippocampus; Humans; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Transgenic; Peptide Fragments; Plaque, Amyloid | 2013 |
Attenuating effect of lisinopril and telmisartan in intracerebroventricular streptozotocin induced experimental dementia of Alzheimer's disease type: possible involvement of PPAR-γ agonistic property.
Topics: Alzheimer Disease; Animals; Benzimidazoles; Benzoates; Congo Red; Dementia; Injections, Intraventricular; Lisinopril; Maze Learning; Mice; PPAR gamma; Reaction Time; Staining and Labeling; Streptozocin; Telmisartan | 2013 |
Synthesis, characterization and potential applications of multifunctional PEO-PPOPEO- magnetic drug delivery system.
Topics: Alzheimer Disease; Chlorides; Coloring Agents; Congo Red; Drug Delivery Systems; Ferric Compounds; Ferrous Compounds; Magnetic Phenomena; Nanocomposites; Poloxamer; Polyethylene Glycols; Propylene Glycols; Surface-Active Agents | 2012 |
MR microscopy of human amyloid-β deposits: characterization of parenchymal amyloid, diffuse plaques, and vascular amyloid.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Brain; Cerebral Amyloid Angiopathy; Congo Red; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Microvessels; Middle Aged; Peptide Fragments; Plaque, Amyloid; Radiography; Young Adult | 2013 |
Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative.
Topics: Alkenes; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzene; Benzene Derivatives; Binding, Competitive; Blood-Brain Barrier; Carbon Radioisotopes; Coloring Agents; Congo Red; Disease Models, Animal; Imaging, Three-Dimensional; Male; Mice; Mice, Transgenic; Microscopy; Peptide Fragments; Plaque, Amyloid; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Stilbenes | 2002 |
Amyloid cored plaques in Tg2576 transgenic mice are characterized by giant plaques, slightly activated microglia, and the lack of paired helical filament-typed, dystrophic neurites.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Brain; Congo Red; Disease Models, Animal; Female; Histocompatibility Antigens Class II; Immunohistochemistry; Macrophage-1 Antigen; Male; Mice; Mice, Inbred Strains; Mice, Transgenic; Microglia; Microscopy, Immunoelectron; Neurites; Neurofibrillary Tangles; Plaque, Amyloid; Receptor, Macrophage Colony-Stimulating Factor | 2002 |
Amyloid fibril formation by a synthetic peptide from a region of human acetylcholinesterase that is homologous to the Alzheimer's amyloid-beta peptide.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Biotinylation; Cell Division; Circular Dichroism; Coloring Agents; Congo Red; Fluorescent Dyes; Humans; Microscopy, Electron; Neurofibrillary Tangles; PC12 Cells; Peptide Fragments; Protein Binding; Rats; Thiazoles | 2002 |
Cerebral amyloid angiopathy in aged Chinese: a clinico-neuropathological study.
Topics: Age Distribution; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Cerebral Amyloid Angiopathy; Cerebrovascular Disorders; China; Congo Red; Female; Frontal Lobe; Humans; Incidence; Male; Middle Aged | 2003 |
Amphotericin B binds to amyloid fibrils and delays their formation: a therapeutic mechanism?
Topics: Alzheimer Disease; Amphotericin B; Amyloid beta-Peptides; Antifungal Agents; Congo Red; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Insulin; Kinetics; Peptide Fragments; Prion Diseases; Protein Binding; Spectrophotometry | 2003 |
The neuroprotective peptide NAP inhibits the aggregation of the beta-amyloid peptide.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; Cell Aggregation; Cells, Cultured; Congo Red; Copper; Microscopy, Electron; Neurons; Oligopeptides; Peptide Fragments; Protein Binding; Protein Structure, Quaternary; Rats | 2003 |
Detection of amyloid plaques in mouse models of Alzheimer's disease by magnetic resonance imaging.
Topics: Alzheimer Disease; Amyloid; Animals; Artifacts; Brain; Cerebral Cortex; Coloring Agents; Congo Red; Corpus Callosum; Disease Models, Animal; Hippocampus; Image Enhancement; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Mesencephalon; Mice; Mice, Transgenic; Putamen | 2004 |
Exclusive association and simultaneous appearance of congophilic plaques and AT8-positive dystrophic neurites in Tg2576 mice suggest a mechanism of senile plaque formation and progression of neuritic dystrophy in Alzheimer's disease.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Congo Red; Disease Models, Animal; Female; Humans; Immunohistochemistry; Mice; Mice, Transgenic; Neurites; Plaque, Amyloid; tau Proteins | 2004 |
Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Death; Cell Survival; Cells, Cultured; Congo Red; Cross-Linking Reagents; Fluorescence; Hippocampus; In Situ Nick-End Labeling; Ligands; Microscopy, Fluorescence; Molecular Chaperones; Molecular Structure; Neurites; Neurons; Peptide Fragments; Piperidines; Rats; Tacrolimus Binding Proteins | 2004 |
Transferrin neutralization of amyloid beta 25-35 cytotoxicity.
Topics: Adolescent; Adult; Alzheimer Disease; Amyloid beta-Peptides; Congo Red; Drug Interactions; Erythrocytes; Hemolysis; Humans; Peptide Fragments; Spectrophotometry; Transferrin | 2004 |
Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoates; Benzothiazoles; Biphenyl Compounds; Blood-Brain Barrier; Brain; Cell Line, Tumor; Congo Red; Curcumin; Diamines; Humans; Ibuprofen; Mice; Mice, Transgenic; Naproxen; Peptide Fragments; Plaque, Amyloid; Protein Binding; Protein Denaturation; Protein Structure, Quaternary; Pyridazines; Solubility; Thiazoles | 2005 |
Interaction between a rat model of cerebral ischemia and beta-amyloid toxicity: inflammatory responses.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Brain; Brain Chemistry; Brain Ischemia; Coloring Agents; Congo Red; Disease Models, Animal; Encephalitis; Endothelins; Gliosis; Immunohistochemistry; Injections; Learning; Male; Motor Skills; Peptide Fragments; Rats; Rats, Wistar | 2005 |
Attacking amyloid.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Congo Red; Humans; Molecular Chaperones; Piperidines; Tacrolimus Binding Proteins | 2005 |
Hsp20, a novel alpha-crystallin, prevents Abeta fibril formation and toxicity.
Topics: Alcohol Dehydrogenase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Babesia bovis; Carrier Proteins; Chromatography, Gel; Congo Red; Heat-Shock Proteins; Histidine; HSP20 Heat-Shock Proteins; Humans; Maltose-Binding Proteins; PC12 Cells; Phosphoproteins; Rats; Recombinant Fusion Proteins | 2005 |
Intraneuronal Abeta, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Congo Red; Disease Models, Animal; Drosophila melanogaster; Inclusion Bodies; Longevity; Movement Disorders; Nerve Degeneration; Nervous System; Neurons; Neuroprotective Agents; Peptide Fragments; Transgenes; Vacuoles | 2005 |
Delineation of positron emission tomography imaging agent binding sites on beta-amyloid peptide fibrils.
Topics: 1-Naphthylamine; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Binding Sites; Congo Red; Contrast Media; Fluorescence; Humans; Positron-Emission Tomography; Radioligand Assay; Thiazoles | 2005 |
Multiple ligand binding sites on A beta(1-40) fibrils.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Binding Sites; Congo Red; Fluorescent Dyes; Humans; Ibuprofen; Ligands; Models, Chemical; Molecular Structure; Naproxen; Peptide Fragments; Protein Binding; Thiazoles | 2005 |
Formation of tau inclusions in knock-in mice with familial Alzheimer disease (FAD) mutation of presenilin 1 (PS1).
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Benzothiazoles; Blotting, Western; Brain; Congo Red; Endopeptidases; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Heterozygote; Hippocampus; Immunohistochemistry; Membrane Proteins; Mice; Mice, Transgenic; Microscopy, Electron; Mutation; Mutation, Missense; Neurons; Peptide Fragments; Phosphorylation; Presenilin-1; Protein Conformation; Sodium Dodecyl Sulfate; tau Proteins; Thiazoles | 2006 |
Cognitive disturbances in old dogs suffering from the canine counterpart of Alzheimer's disease.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Age Factors; Aging; Aldehydes; Alzheimer Disease; Amyloid beta-Peptides; Animals; Atrophy; Behavior, Animal; Cerebral Cortex; Cognition Disorders; Congo Red; Demyelinating Diseases; Deoxyguanosine; Disease Models, Animal; Dogs; Female; Immunohistochemistry; Lipofuscin; Male; Statistics, Nonparametric | 2006 |
Beta-protein/A4 deposits are not associated with hyperphosphorylated tau in somatostatin neurons in the hypothalamus of Alzheimer's disease patients.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Antibodies, Monoclonal; Coloring Agents; Congo Red; Humans; Hypothalamus; Immunohistochemistry; Middle Aged; Neurons; Phosphorylation; Silver Staining; Somatostatin; Staining and Labeling; tau Proteins | 2006 |
Quantification of cerebral amyloid angiopathy and parenchymal amyloid plaques with Congo red histochemical stain.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Cerebral Amyloid Angiopathy; Congo Red; Histocytochemistry; Humans; Image Processing, Computer-Assisted; Mice; Mice, Transgenic; Plaque, Amyloid | 2006 |
Tau aggregation and toxicity in a cell culture model of tauopathy.
Topics: Alzheimer Disease; Cell Line; Coloring Agents; Congo Red; Dose-Response Relationship, Drug; Humans; Membrane Proteins; Microtubules; Models, Biological; Phosphorylation; Protein Binding; Protein Isoforms; Protein Processing, Post-Translational; Time Factors; Tubulin | 2007 |
Upregulation of tPA/plasminogen proteolytic system in the periphery of amyloid deposits in the Tg2576 mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain Chemistry; Coloring Agents; Congo Red; Fluorescent Dyes; Humans; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Transgenic; Peptide Fragments; Plaque, Amyloid; Plasminogen; Tissue Plasminogen Activator; Up-Regulation | 2007 |
Congo red and thioflavin-T analogs detect Abeta oligomers.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cell Line, Tumor; Coloring Agents; Congo Red; Fluorescent Dyes; Hippocampus; Humans; Microscopy, Electron, Transmission; Neuroblastoma; Surface Plasmon Resonance; Thiazoles | 2008 |
A standardized method to automatically segment amyloid plaques in Congo Red stained sections from Alzheimer transgenic mice.
Topics: Algorithms; Alzheimer Disease; Animals; Artificial Intelligence; Brain; Colorimetry; Congo Red; Contrast Media; Disease Models, Animal; Humans; Image Enhancement; Image Interpretation, Computer-Assisted; Mice; Mice, Transgenic; Pattern Recognition, Automated; Plaque, Amyloid; Reproducibility of Results; Sensitivity and Specificity | 2007 |
Binding of proteases to fibrillar amyloid-beta protein and its inhibition by Congo red.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Binding Sites; Brain; Coloring Agents; Congo Red; Dose-Response Relationship, Drug; Humans; Insulysin; Neprilysin; Neurofibrillary Tangles; Peptide Hydrolases; Plaque, Amyloid; Trypsin | 2007 |
Congophilic angiopathy in the pathogenesis of Alzheimer's degeneration.
Topics: Aged; Alzheimer Disease; Amyloidosis; Cerebrovascular Disorders; Congo Red; Dementia; Female; Humans; Male; Middle Aged; Staining and Labeling | 1981 |
Amyloid-like (Congophilic) neurofibrillary tangles do not react with neurofilament antisera in Alzheimer's cerebral cortex.
Topics: Alzheimer Disease; Amyloid; Cerebral Cortex; Congo Red; Cytoskeleton; Epitopes; Fluorescent Antibody Technique; Humans; Neurofibrils | 1984 |
Analysis of staining methods for different cortical plaques in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Cerebral Cortex; Congo Red; Evaluation Studies as Topic; Female; Formaldehyde; Humans; Immunohistochemistry; Male; Middle Aged; Paraffin Embedding; Silver Staining; Staining and Labeling | 1994 |
Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein E.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Apolipoproteins E; Congo Red; Humans; Microscopy, Electron; Molecular Sequence Data; Neurofibrillary Tangles; Protein Conformation; Recombinant Proteins; Staining and Labeling | 1995 |
Conformational mimicry in Alzheimer's disease. Role of apolipoproteins in amyloidogenesis.
Topics: Alzheimer Disease; Amyloid; Apolipoprotein A-I; Apolipoproteins; Congo Red; Humans; Immunohistochemistry; Microscopy, Electron; Molecular Conformation; Molecular Mimicry | 1995 |
Non-A beta component of Alzheimer's disease amyloid (NAC) is amyloidogenic.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Congo Red; Humans; Molecular Sequence Data; Protein Structure, Secondary | 1995 |
Enhanced detection of congo-red-positive amyloid deposits in muscle fibers of inclusion body myositis and brain of Alzheimer's disease using fluorescence technique.
Topics: Alzheimer Disease; Amyloid; Brain; Congo Red; Fluorescence; Humans; Inclusion Bodies; Muscles; Myositis | 1993 |
Selective inhibition of Abeta fibril formation.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Circular Dichroism; Congo Red; Humans; Islet Amyloid Polypeptide; Kinetics; Microscopy, Electron; Piperidines; Prealbumin; Protein Conformation; Scattering, Radiation | 1996 |
Seeding of A beta fibril formation is inhibited by all three isotypes of apolipoprotein E.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Apolipoprotein E2; Apolipoprotein E3; Apolipoprotein E4; Apolipoproteins E; Brain; Coloring Agents; Congo Red; Escherichia coli; Humans; Interleukin-4; Peptide Fragments; Protein Conformation; Recombinant Proteins; Serum Albumin, Bovine | 1996 |
Alzheimer's disease-associated presenilins 1 and 2: accelerated amyloid fibril formation of mutant 410 Cys-->Tyr and 141 Asn-->Ile peptides.
Topics: Alzheimer Disease; Amyloid; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 14; Congo Red; Humans; Membrane Proteins; Microscopy, Electron; Microscopy, Polarization; Mutation; Peptide Fragments; Presenilin-1; Presenilin-2; Spectrometry, Fluorescence | 1997 |
Alzheimer's amyloid-beta peptide inhibits sodium/calcium exchange measured in rat and human brain plasma membrane vesicles.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Calcium; Cell Membrane; Coated Vesicles; Congo Red; Frontal Lobe; Humans; Kinetics; Molecular Sequence Data; Monensin; Peptide Fragments; Rats; Sodium; Sodium-Calcium Exchanger | 1997 |
Acceleration of amyloid fibril formation by specific binding of Abeta-(1-40) peptide to ganglioside-containing membrane vesicles.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Congo Red; Fluorescent Dyes; Gangliosides; Humans; Liposomes; Peptide Fragments; Protein Binding; Spectrometry, Fluorescence | 1997 |
Amyloid beta-protein (Abeta) 1-40 but not Abeta1-42 contributes to the experimental formation of Alzheimer disease amyloid fibrils in rat brain.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Birefringence; Cerebral Cortex; Coloring Agents; Congo Red; Endopeptidases; Female; Hippocampus; Humans; Injections; Microscopy, Electron; Nerve Degeneration; Nerve Tissue Proteins; Peptide Fragments; Plaque, Amyloid; Rats; Rats, Sprague-Dawley | 1997 |
Inhibiting the formation of classical C3-convertase on the Alzheimer's beta-amyloid peptide.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Brain; Chelating Agents; Coloring Agents; Complement Activation; Complement C1 Inactivator Proteins; Complement C1q; Complement C3-C5 Convertases; Complement C3a; Complement C4; Congo Red; Egtazic Acid; Humans; Nerve Degeneration; Protease Inhibitors | 1997 |
Chrysamine-G, a lipophilic analogue of Congo red, inhibits A beta-induced toxicity in PC12 cells.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzoates; Biphenyl Compounds; Coloring Agents; Congo Red; Drug Antagonism; Humans; PC12 Cells; Rats | 1998 |
The sulfate moieties of glycosaminoglycans are critical for the enhancement of beta-amyloid protein fibril formation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloidosis; Animals; Coloring Agents; Congo Red; Fibrinolytic Agents; Glycosaminoglycans; Heparin; Neurofibrillary Tangles; Neurons; Peptide Fragments; Sulfates; Swine | 1999 |
Gel electrophoretic distinction between toxic and nontoxic forms of beta-amyloid (1-40).
Topics: Alzheimer Disease; Amyloid beta-Peptides; Congo Red; Electrophoresis, Capillary; Electrophoresis, Polyacrylamide Gel; Humans; Hydrogen-Ion Concentration; Isomerism; Peptide Fragments; Solubility; Temperature | 1999 |
Evidence for seeding of beta -amyloid by intracerebral infusion of Alzheimer brain extracts in beta -amyloid precursor protein-transgenic mice.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antigen-Antibody Reactions; Cerebral Arteries; Coloring Agents; Congo Red; Disease Models, Animal; Encephalitis; Female; Hippocampus; Humans; Injections, Intraventricular; Male; Mice; Mice, Transgenic; Nerve Degeneration | 2000 |
Human apolipoprotein C-II forms twisted amyloid ribbons and closed loops.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Apolipoprotein C-II; Apolipoproteins C; Benzothiazoles; Chromatography, Gel; Circular Dichroism; Congo Red; Humans; Microscopy, Electron; Protein Conformation; Spectrometry, Fluorescence; Thiazoles; Tryptophan; Ultracentrifugation | 2000 |
X-34, a fluorescent derivative of Congo red: a novel histochemical stain for Alzheimer's disease pathology.
Topics: Aged; Aged, 80 and over; Alkenes; Alzheimer Disease; Amyloid; Amyloidosis; Benzoates; Benzothiazoles; Coloring Agents; Congo Red; Female; Fluorescent Dyes; Histocytochemistry; Humans; Male; Middle Aged; Neurofibrillary Tangles; Plaque, Amyloid; Protein Structure, Secondary; Silver; Thiazoles | 2000 |
Amyloid-like inclusions in Huntington's disease.
Topics: Alzheimer Disease; Amyloid; Animals; Birefringence; Brain; Congo Red; Humans; Huntington Disease; Mice; Microscopy, Confocal; Microscopy, Polarization; Neurons; Staining and Labeling | 2000 |
Age-dependent induction of congophilic neurofibrillary tau inclusions in tau transgenic mice.
Topics: Aging; Alzheimer Disease; Animals; Central Nervous System; Cerebral Cortex; Congo Red; Humans; Immunohistochemistry; Mice; Mice, Transgenic; Microscopy, Electron; Neurofibrillary Tangles; Neurons; Solubility; tau Proteins; Time Factors | 2001 |
Alpha-1-antichymotrypsin promotes beta-sheet amyloid plaque deposition in a transgenic mouse model of Alzheimer's disease.
Topics: alpha 1-Antichymotrypsin; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Astrocytes; Congo Red; Crosses, Genetic; Disease Models, Animal; Glial Fibrillary Acidic Protein; Head Injuries, Penetrating; Hippocampus; Humans; Mice; Mice, Transgenic; Organ Specificity; Plaque, Amyloid; Platelet-Derived Growth Factor; Promoter Regions, Genetic; Protein Structure, Secondary | 2001 |
A novel action of alzheimer's amyloid beta-protein (Abeta): oligomeric Abeta promotes lipid release.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Cells, Cultured; Centrifugation, Density Gradient; Cholesterol; Congo Red; Culture Media, Conditioned; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radical Scavengers; Lipid Metabolism; Lipids; Macromolecular Substances; Microscopy, Electron; Neurons; Peptide Fragments; Phosphatidylcholines; Precipitin Tests; Protein Kinase C; Rats; Time Factors | 2001 |
Early formation of mature amyloid-beta protein deposits in a mutant APP transgenic model depends on levels of Abeta(1-42).
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Brain; Congo Red; Disease Models, Animal; Gene Expression Regulation, Developmental; Mice; Mice, Neurologic Mutants; Mice, Transgenic; Microscopy, Electron; Mutagenesis, Insertional; Mutation; Neurites; Neurons; Peptide Fragments; Plaque, Amyloid; Presynaptic Terminals; Promoter Regions, Genetic; Thiazoles | 2001 |
Number of Abeta inoculations in APP+PS1 transgenic mice influences antibody titers, microglial activation, and congophilic plaque levels.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antibody Formation; Congo Red; Leukocyte Common Antigens; Membrane Proteins; Mice; Mice, Transgenic; Microglia; Neurofibrillary Tangles; Presenilin-1 | 2001 |
Mutations that reduce aggregation of the Alzheimer's Abeta42 peptide: an unbiased search for the sequence determinants of Abeta amyloidogenesis.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloidosis; Bias; Binding Sites; Circular Dichroism; Congo Red; Fluorescence; Green Fluorescent Proteins; Humans; Hydrophobic and Hydrophilic Interactions; Luminescent Proteins; Mutation; Peptide Fragments; Protein Binding; Protein Denaturation; Protein Structure, Secondary; Recombinant Fusion Proteins; Solubility | 2002 |
Senile degenerative brain lesions and dementia.
Topics: Aged; Aging; Alzheimer Disease; Amyloidosis; Brain Diseases; Capillaries; Cerebral Hemorrhage; Congo Red; Dementia; Epilepsy; Female; Hippocampus; Humans; Hypertension; Infarction; Male; Microscopy, Fluorescence; Microscopy, Polarization; Middle Aged; Neurofibrils; Staining and Labeling; Vascular Diseases | 1975 |
Congophilic microangiopathy in the pathogenesis of Alzheimer's syndrome (presenile dementia).
Topics: Alzheimer Disease; Amyloid; Blood-Brain Barrier; Brain; Congo Red; Dementia; Humans; Nerve Tissue Proteins | 1979 |
Alzheimer's disease brain-derived ubiquitin has amyloid-enhancing factor activity: behavior of ubiquitin during accelerated amyloidogenesis.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amino Acid Sequence; Animals; Brain; Calcium Chloride; Congo Red; Electrophoresis, Polyacrylamide Gel; Female; Glycoproteins; Humans; Immunoblotting; Immunohistochemistry; Male; Mice; Molecular Sequence Data; Serum Amyloid A Protein; Ubiquitins | 1991 |
Fluorescence activated cell sorting (FACS) as a separation method for neurofibrillary tangles in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Brain; Cell Separation; Congo Red; Down Syndrome; Flow Cytometry; Humans; Middle Aged; Neurofibrils; Particle Size; Staining and Labeling | 1986 |
Congophilia in cerebral amyloidosis is modified by inactivation procedures on slow transmissible pathogens.
Topics: Alzheimer Disease; Amyloid; Amyloidosis; Brain; Brain Diseases; Congo Red; Creutzfeldt-Jakob Syndrome; Dementia; Humans; Prions; Staining and Labeling | 1986 |
Observation of morphological relationships between angiopathic blood vessels and degenerative neurites in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Benzothiazoles; Brain; Cerebrovascular Disorders; Congo Red; Female; Humans; Neurofibrils; Staining and Labeling; Thiazoles | 1987 |
Morphology and distribution of plaque and related deposits in the brains of Alzheimer's disease and control cases. An immunohistochemical study using amyloid beta-protein antibody.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Antibodies, Monoclonal; Brain; Brain Chemistry; Congo Red; Female; Humans; Immunohistochemistry; Male; Middle Aged; Silver | 1989 |
Congo red staining on 1 micron de-plasticized sections for detection of lesions in Alzheimer's disease and related disorders.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Congo Red; Female; Histological Techniques; Humans; Male | 1989 |
The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid; Antibodies, Monoclonal; Astrocytes; Brain; Brain Chemistry; Chondroitin Sulfate Proteoglycans; Congo Red; Glycosaminoglycans; Heparan Sulfate Proteoglycans; Heparitin Sulfate; Humans; Immunoenzyme Techniques; Immunohistochemistry; Microscopy, Electron; Neurofibrils; Neurons; Proteoglycans | 1988 |
beta-amyloid protein of Alzheimer's disease is found in cerebral and spinal cord vascular malformations.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Arteriovenous Malformations; Birefringence; Child; Child, Preschool; Congo Red; Female; Humans; Immunohistochemistry; Infant; Intracranial Arteriovenous Malformations; Male; Microscopy, Electron; Middle Aged; Spinal Cord | 1988 |
Negative correlations between parenchymal amyloid and vascular amyloid in hippocampus.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Blood Vessels; Congo Red; Hippocampus; Histocytochemistry; Humans; Middle Aged; Statistics as Topic | 1988 |
Cerebral amyloid angiopathy in dementia and old age.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Amyloidosis; Blood Vessels; Brain; Cerebral Infarction; Cerebrovascular Disorders; Congo Red; Female; Histocytochemistry; Humans; Male; Middle Aged | 1986 |
Relationship between numbers of cortical argentophilic and congophilic senile plaques in the brains of elderly people with and without senile dementia of Alzheimer type.
Topics: Aged; Alzheimer Disease; Amyloidosis; Cerebral Cortex; Congo Red; Humans; Nerve Degeneration; Neurofibrils; Neurons | 1985 |