concanavalin-a and Purpura--Thrombocytopenic--Idiopathic

concanavalin-a has been researched along with Purpura--Thrombocytopenic--Idiopathic* in 1 studies

Other Studies

1 other study(ies) available for concanavalin-a and Purpura--Thrombocytopenic--Idiopathic

Article	Year
Impaired suppressor function of T cells induced by autologous mixed lymphocyte reaction in patients with idiopathic thrombocytopenic purpura. Acta haematologica, 1992, Volume: 87, Issue:1-2 Autologous mixed lymphocyte reaction (AMLR)-induced suppressor function was studied in 12 patients with chronic idiopathic thrombocytopenic purpura (ITP). The function was found to be significantly impaired (20 +/- 55%; p less than 0.005) compared with normal subjects (69 +/- 25%). AMLRs in these patients were significantly decreased (p less than 0.05) compared with normal subjects. There was no significant correlation between AMLR-induced suppressor function and platelet counts. Nine patients were studied for AMLR-induced suppressor function before and after splenectomy. The platelet counts increased significantly as a result of splenectomy, but the AMLR-induced suppressor function showed no significant improvement. The results of this study suggest that suppressor dysfunction in ITP may be an immunologic defect irrespective of disease activity. We consider that this abnormality may reflect in vivo failure of the immunoregulatory (feedback) mechanism in ITP. Topics: Adult; Aged; Concanavalin A; Female; Humans; Lymphocyte Culture Test, Mixed; Male; Middle Aged; Platelet Count; Purpura, Thrombocytopenic, Idiopathic; Splenectomy; T-Lymphocytes, Regulatory	1992

Article

Year

Impaired suppressor function of T cells induced by autologous mixed lymphocyte reaction in patients with idiopathic thrombocytopenic purpura.

Acta haematologica, 1992, Volume: 87, Issue:1-2

Autologous mixed lymphocyte reaction (AMLR)-induced suppressor function was studied in 12 patients with chronic idiopathic thrombocytopenic purpura (ITP). The function was found to be significantly impaired (20 +/- 55%; p less than 0.005) compared with normal subjects (69 +/- 25%). AMLRs in these patients were significantly decreased (p less than 0.05) compared with normal subjects. There was no significant correlation between AMLR-induced suppressor function and platelet counts. Nine patients were studied for AMLR-induced suppressor function before and after splenectomy. The platelet counts increased significantly as a result of splenectomy, but the AMLR-induced suppressor function showed no significant improvement. The results of this study suggest that suppressor dysfunction in ITP may be an immunologic defect irrespective of disease activity. We consider that this abnormality may reflect in vivo failure of the immunoregulatory (feedback) mechanism in ITP.

Topics: Adult; Aged; Concanavalin A; Female; Humans; Lymphocyte Culture Test, Mixed; Male; Middle Aged; Platelet Count; Purpura, Thrombocytopenic, Idiopathic; Splenectomy; T-Lymphocytes, Regulatory

1992