concanavalin-a has been researched along with Psittacosis* in 2 studies
2 other study(ies) available for concanavalin-a and Psittacosis
| Article | Year |
|---|---|
The development of proliferative responses of ovine peripheral blood mononuclear cells to Chlamydia psittaci during pregnancy.
In vitro lymphoproliferative responses to Chlamydia psittaci elementary bodies were detected in the peripheral blood mononuclear cells of pregnant sheep infected with C. psittaci. These responses were suppressed in cells collected in the immediate peri-parturient period, but returned to levels significantly above background within 14 days. Infection also suppressed the lymphoproliferative response to the T-cell mitogen Con A until abortion or lambing, but did not affect the proliferative response to the B-cell mitogen LPS. Topics: Abortion, Veterinary; Animals; B-Lymphocytes; Chlamydophila psittaci; Concanavalin A; Female; Lipopolysaccharides; Lymphocyte Activation; Placenta; Pregnancy; Pregnancy Complications, Infectious; Psittacosis; Sheep; Sheep Diseases; T-Lymphocytes | 1994 |
Modulation of the host immune response as a result of Chlamydia psittaci infection.
After intraperitoneal injection of mice with infectious, inactivated, or envelope preparations of the elementary body of Chlamydia psittaci, lymphocyte transformation of spleen cells to the mitogens concanavalin A, phytohemagglutinin, and lipopolysaccharide was significantly reduced 1 and 2 weeks postinjection. Lymphocyte response returned to the control values by 4 weeks. Similarly, transformation of cells by chlamydial antigen was not detected until 4 weeks postinjection. Injection of the noninfectious intracellular reticulate body, in contrast, had little effect on transformation of cells to concanavalin A. When control spleen cells were incubated with infectious or inactivated elementary bodies in vitro, response to all three mitogens was also reduced. The sooner the organisms were added after the addition of mitogen, the greater the reduction in transformation. Incubation with elementary body envelopes and reticulate bodies had no effect on lymphocyte transformation of the spleen cells to concanavalin A. The relationship between the observed ability to reduce the response in the in vitro assay of lymphocyte transformation and the actual in vivo establishment of infection is discussed. Topics: Animals; Chlamydophila psittaci; Concanavalin A; Female; Lipopolysaccharides; Lymphocyte Activation; Macrophages; Mice; Phytohemagglutinins; Psittacosis | 1982 |