concanavalin-a and Meningioma

concanavalin-a has been researched along with Meningioma* in 2 studies

Other Studies

2 other study(ies) available for concanavalin-a and Meningioma

ArticleYear
Concanavalin A target cells in human brain tumours.
    Journal of the neurological sciences, 1984, Volume: 63, Issue:3

    Using a lectin-peroxidase method, Concanavalin A binding was examined on formalin-fixed paraffin-embedded biopsy specimens (n = 143) of the most frequent central nervous system tumours. The brain tumours included oligodendrogliomas, astrocytomas, glioblastomas, ependymomas, neurinomas, meningiomas, medulloblastomas and plexus papillomas. In oligodendroglioma cells, only a weak granular intracytoplasmic staining was observed. The astrocytomas showed a strong reaction in fibrillary astrocytes and in tumour areas undergoing small cystic degeneration. Staining of protoplasmic astrocytes was weaker; pilocytic astrocytes demonstrated poor perinuclear staining. Intracytoplasmic Con A binding in gemistocytic astrocytes was distinct but inconstant and rather diffuse. In the glioblastomas the lymphocyte-like small astrocytes were negative. Giant multinucleated astrocytes stained strongly. In ependymomas no or at most a weak perinuclear reaction was observed, whereas the acceptor density was as high as in the normal ependymocytes in areas where the tumour was capable of producing organotypical structures. Plexus papillomas showed a strong intracytoplasmic staining comparable to the normal plexus epithelial cell. This feature was preserved in the malignant variants. In general, meningiomas and neurinomas were negative. Xanthomatous-degenerated meningioma cells, however, showed a distinct to strong intracytoplasmic staining. This feature was characteristic for the xanthomatous subtype of meningiomas. Granular cells with strong intracytoplasmic Con A staining often occurred at the border of fibrillary to reticular differentiated areas of neurinomas. Medulloblastomas were completely negative. Our results indicate that Con A binding to human brain tumours is specific and rather cytotypical than histotypical . The Con A acceptor density is probably related to the grade of differentiation. Lectin mapping of tumours leads to cytotypical binding patterns which may contribute to the differential diagnosis of neoplasias.

    Topics: Astrocytoma; Brain; Brain Neoplasms; Cerebellar Neoplasms; Concanavalin A; Ependymoma; Glioma; Humans; Immunoenzyme Techniques; Medulloblastoma; Meningeal Neoplasms; Meningioma; Neurilemmoma; Oligodendroglioma; Papilloma; Receptors, Concanavalin A

1984
Pseudopsammoma bodies in meningotheliomatous meningioma. A histochemical and ultrastructural study.
    Acta neurochirurgica, 1983, Volume: 68, Issue:1-2

    A case of meningioma arising from the right sphenoidal ridge is presented. Histologically, the tumour was composed of whorls of meningotheliomatous cells and many tumour cells containing intracellular inclusions were PAS positive, but diastase and neuraminidase resistant. The inclusions were named pseudopsammoma bodies by Kepes in 1961. The meningioma with pseudopsammoma bodies are a very rare entity and have been described in only 7 previous reports. We had an opportunity to examine one case of a meningioma with pseudopsammoma bodies. Electron microscopically, these substances were located in the intracellular spaces lined by microvilli. In earlier reports, the substances were said to be secretory products and a possibility of meningioma cell differentiation to secretory cell was postulated. Using the Concanavalin A staining method, the results of our present study strongly support this opinion.

    Topics: Adult; Brain Neoplasms; Concanavalin A; Female; Histocytochemistry; Horseradish Peroxidase; Humans; Meningioma

1983