concanavalin-a and Leishmaniasis--Mucocutaneous

concanavalin-a has been researched along with Leishmaniasis--Mucocutaneous* in 3 studies

Other Studies

3 other study(ies) available for concanavalin-a and Leishmaniasis--Mucocutaneous

ArticleYear
Serum protein from Leishmania brasiliensis infected hamster that suppress lymphocyte response of normal hamster lymphocytes.
    Zeitschrift fur Parasitenkunde (Berlin, Germany), 1986, Volume: 72, Issue:3

    Immunosuppression in Leishmania brasiliensis (LB) or L. donovani (LD) infected hamsters is correlated with the appearance of two serum protein bands found at 21, 60, 68 and 76 days post LB-infection and with eight bands at 21 days post-LD-infection probably of host origin. A protein band from LB-infected hamster serum isolated by electrofocusing, suppressed the blastogenic response of normal lymphocytes to T and B cell mitogens.

    Topics: Animals; Blood Proteins; Concanavalin A; Cricetinae; Isoelectric Focusing; Leishmania braziliensis; Leishmania donovani; Leishmaniasis, Mucocutaneous; Leishmaniasis, Visceral; Lymphocyte Activation; Lymphokines; Male; Pokeweed Mitogens

1986
Human american cutaneous leishmaniasis (Leishmania b. braziliensis) in Brazil: lymphoproliferative responses and influence of therapy.
    Clinical and experimental immunology, 1986, Volume: 64, Issue:2

    The host defence to Leishmania parasites is believed to depend on cell-mediated immune responses. Three groups of inhabitants from an endemic area in Rio de Janeiro were studied: Group I consisted of 28 patients with cutaneous lesions, Group II of 28 healthy persons (without ulcers) but with positive Montenegro skin tests (MST) and Group III of 29 healthy persons with negative MST. The peripheral blood lymphocyte proliferative responses induced by leishmanial-antigens (Leishmania b. braziliensis lymphoproliferative response) as well as by Concanavalin A (Con A-lymphoproliferative response), both measured by 3H-thymidine incorporation were tested in each group. The results showed that: The Leishmania b. braziliensis lymphoproliferative response (L.b.b.-LPR) in healthy persons with positive MST (Group II) was higher than in patients prior to therapy (Group I); A significantly higher L.b.b.-LPR was found in patients and healthy persons with positive MST as compared to Group III (negative MST); The L.b.b.-LPR of Group I (patients) increased during antimonial therapy--this might possibly be related to the destruction of parasites; The levels of L.b.b.-LPR after therapy became similar to the ones before therapy; All individuals from the three groups had a positive Con A-lymphoproliferative response (Con A-LPR); All patients who had a histopathological picture of granulomatous reaction also had a positive L.b.b.-LPR; A poor response to antimonial therapy observed in six patients was associated with a low L.b.b.-LPR.

    Topics: Adult; Antigens, Protozoan; Concanavalin A; Drug Resistance, Microbial; Humans; Leishmania braziliensis; Leishmaniasis, Mucocutaneous; Lymphocyte Activation; Meglumine; Skin; Sorbitol

1986
Mechanisms associated with immunoregulation in human American cutaneous leishmaniasis.
    Clinical and experimental immunology, 1984, Volume: 57, Issue:2

    Mechanisms possibly involved in the regulation of the immune response were evaluated in 49 patients with American cutaneous leishmaniasis (ACL). The patients were classified on the basis of clinical and histopathological criteria as suffering localized (LCL), mucocutaneous (MCL) or diffuse (DCL) forms of the disease. A significant leishmanial antigen-induced suppression of in vitro mitogen responsiveness was demonstrated in the DCL group, but not in the other two diseases states. Lack of suppressive activity was particularly evident in MCL, this being the group that presented the highest in vivo and in vitro reactivity to the parasite antigens. In fact, a significant inverse correlation was found between the degree of suppression and the antigen-induced lymphocyte proliferative response. In contrast, a mixture of mononuclear cells from MCL patients and normal subjects showed higher that expected responses to mitogen, while this increase was not observed in co-cultures of DCL and normal mononuclear cells. Due to their possible modulatory influences, circulating immune complexes were also evaluated in these patient groups, higher levels being found in MCL and DCL patients than in either LCL or controls. The possible mechanisms involved in the regulation of the immune response to the protozoan in the complex disease spectrum of ACL are discussed in relation to anergy in DCL and hyperresponsiveness in MCL.

    Topics: Antigen-Antibody Complex; Antigens; Cell Division; Concanavalin A; Female; Humans; Leishmania; Leishmaniasis; Leishmaniasis, Mucocutaneous; Lymphocyte Activation; Male; Phytohemagglutinins

1984
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