concanavalin-a and Hamartoma

The existence of suppressor mononuclear cells were demonstrated in two lymphoproliferative disorders: giant lymph node hyperplasia and thymona. The three patients tested also showed cell-mediated immunodeficiency as expressed in the low number of T cells, negative graft versus host reactions and negative skin tests; the one patient tested with phytohemagglutinin (PHA) and concavalin A (Con A) showed a low response. Suppressor activity was tested with a new experimental model, the local xenogeneic graft versus host reaction. It is proposed that this model be used for testing suppressor activities in other human disorders as well.

Topics: Adolescent; Animals; Child; Child, Preschool; Concanavalin A; Female; Graft vs Host Reaction; Hamartoma; Humans; Hyperplasia; Lymph Nodes; Lymphocyte Activation; Male; Models, Biological; Monocytes; Phytohemagglutinins; Rats; Skin Tests; T-Lymphocytes, Regulatory; Thymoma