concanavalin-a and Genital-Diseases--Female

Cell-mediated immunity (investigated by in vitro mitogen/antigen induced lymphocyte proliferation) is known to be depressed in the post-operative period. In the present investigation, performed with halothane/nitrous oxide inhalational anaesthesia in healthy patients without trauma (eye surgery) and with operative tissue trauma (gynaecological operations), only the combination of major surgery with halothane/nitrous oxide anaesthesia was associated with a depression of lymphocyte reactivity to phytohaemagglutin (PHA-P), Concanavalin A (Con A) and pokeweed mitogen (PWM). This lasted for 3-10 days post-operatively.

Topics: Adult; Concanavalin A; Eye Diseases; Female; Genital Diseases, Female; Halothane; Humans; Lymphocyte Activation; Male; Middle Aged; Nitrous Oxide; Phytohemagglutinins; Pokeweed Mitogens

In this study, neuroleptanaesthesia reduced the reactivity of lymphocytes to phytohaemagglutin (PHA-P) and pokeweed mitogen (PWM) in patients in a manner similar to that seen with halothane/nitrous oxide and enflurane/nitrous oxide inhalational anaesthesia. These findings began 4 h post-operatively, lasted throughout the first post-operative day and were similar in both operative trauma groups (eye surgery/gynaecological surgery). However, unlike the situation with the inhalational agent, Concanavalin A (Con A)-induced proliferation did not alter. It was also noted that, on the third post-operative day in both trauma groups, PHA-P- and PWM-induced proliferation ratios were significantly higher than were the pre-operative values. These findings could be the result of a specific effect of neuroleptanaesthesia.

Topics: Adult; Concanavalin A; Eye Diseases; Female; Genital Diseases, Female; Humans; Lymphocyte Activation; Male; Middle Aged; Neuroleptanalgesia; Phytohemagglutinins; Pokeweed Mitogens; Time Factors

The authors studied early changes in immune state by the nuclear refringence test in 12 patients undergoing gynaecological surgery for non-malignant conditions. The test was performed before and thirty minutes after the induction of anaesthesia. Twenty five per cent of the patients showed abnormalities of the nuclear refringence test in the presence of Con A2. The interpretation of the results and the predictive value of the test are discussed.

Topics: Adult; Anesthesia, General; Concanavalin A; Female; Genital Diseases, Female; Humans; Immunity, Cellular; Inosine Pranobex; Middle Aged; Time Factors

Topics: Adolescent; Adrenal Gland Diseases; Animals; Antibody Formation; Antibody-Producing Cells; Autoimmune Diseases; B-Lymphocytes; Concanavalin A; Cytotoxicity Tests, Immunologic; Female; Genital Diseases, Female; Gonads; Humans; Immunity; Immunoglobulin Fc Fragments; Immunoglobulin G; Lectins; Lymphocytes; Mitogens; Sheep; T-Lymphocytes; Thyroid Diseases