concanavalin-a and Duodenal-Ulcer

Duodenal ulcers were induced in rats by cysteamine administration. Time-course changes in duodenal hexosamine, blood flow and intragastric pH were measured, as well as changes in the susceptibility of Brunner's glands to concanavalin A (Con A) staining. Hexosamine contents in the duodenum decreased significantly at 5 and 24 h. In the control group, Brunner's glands were stained brown using Con A staining. One day after cysteamine administration, the extent of Con A staining markedly decreased. At 3 and 7 days, gland susceptibility to staining was essentially the same as that of the control group.

Topics: Animals; Brunner Glands; Concanavalin A; Cysteamine; Duodenal Ulcer; Duodenum; Gastric Mucosa; Glycoproteins; Hexosamines; Hydrogen-Ion Concentration; Intestinal Mucosa; Male; Rats; Rats, Inbred Strains; Regional Blood Flow