concanavalin-a and Chromosome-Deletion

concanavalin-a has been researched along with Chromosome-Deletion* in 2 studies

Other Studies

2 other study(ies) available for concanavalin-a and Chromosome-Deletion

Article	Year
Murine TIMP-2 gene-targeted mutation. Annals of the New York Academy of Sciences, 1999, Jun-30, Volume: 878 Topics: Animals; Base Sequence; Cells, Cultured; Chromosome Deletion; Concanavalin A; Enzyme Activation; Fibroblasts; Gelatinases; Matrix Metalloproteinase 2; Metalloendopeptidases; Mice; Mice, Knockout; Molecular Sequence Data; Mutagenesis; Recombination, Genetic; Tissue Inhibitor of Metalloproteinase-2	1999
Generation and analysis of interleukin-4 deficient mice. Science (New York, N.Y.), 1991, Nov-01, Volume: 254, Issue:5032 Interleukin-4 (IL-4) promotes the growth and differentiation of many hematopoietic cells in vitro; in particular, it directs the immunoglobulin (Ig) class switch to IgG1 and IgE. Mice homozygous for a mutation that inactivates the IL-4 gene were generated to test the requirement for IL-4 in vivo. In the mutant mice T and B cell development was normal, but the serum levels of IgG1 and IgE were strongly reduced. The IgG1 dominance in a T cell-dependent immune response was lost, and IgE was not detectable upon nematode infection. Thus, some but not all of the in vitro properties of IL-4 are critical for the physiology of the immune system in vivo. Topics: Aging; Alleles; Animals; B-Lymphocytes; Blotting, Southern; Chromosome Deletion; Concanavalin A; DNA; Female; Interleukin-4; Lymph Nodes; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Restriction Mapping; Spleen; T-Lymphocytes; Thymus Gland	1991

Article

Year

Annals of the New York Academy of Sciences, 1999, Jun-30, Volume: 878

Topics: Animals; Base Sequence; Cells, Cultured; Chromosome Deletion; Concanavalin A; Enzyme Activation; Fibroblasts; Gelatinases; Matrix Metalloproteinase 2; Metalloendopeptidases; Mice; Mice, Knockout; Molecular Sequence Data; Mutagenesis; Recombination, Genetic; Tissue Inhibitor of Metalloproteinase-2

1999

Generation and analysis of interleukin-4 deficient mice.

Science (New York, N.Y.), 1991, Nov-01, Volume: 254, Issue:5032

Interleukin-4 (IL-4) promotes the growth and differentiation of many hematopoietic cells in vitro; in particular, it directs the immunoglobulin (Ig) class switch to IgG1 and IgE. Mice homozygous for a mutation that inactivates the IL-4 gene were generated to test the requirement for IL-4 in vivo. In the mutant mice T and B cell development was normal, but the serum levels of IgG1 and IgE were strongly reduced. The IgG1 dominance in a T cell-dependent immune response was lost, and IgE was not detectable upon nematode infection. Thus, some but not all of the in vitro properties of IL-4 are critical for the physiology of the immune system in vivo.

Topics: Aging; Alleles; Animals; B-Lymphocytes; Blotting, Southern; Chromosome Deletion; Concanavalin A; DNA; Female; Interleukin-4; Lymph Nodes; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Restriction Mapping; Spleen; T-Lymphocytes; Thymus Gland

1991