concanavalin-a has been researched along with Carcinoma--Large-Cell* in 1 studies
1 other study(ies) available for concanavalin-a and Carcinoma--Large-Cell
| Article | Year |
|---|---|
Sera of lung cancer patients affect the release of Th1, Th2 and monocyte-derived cytokines, and the expression of IL-2Ralpha by normal, stimulated mononuclear cells.
We have shown that the sera of lung cancer patients affect the response of ConA-stimulated normal peripheral blood mononuclear cells by decreasing the expression of IL-2Ralpha and inhibiting the release of IL-1beta and IL-2. A tendency to enhance the release of IL-6 was also observed. We conclude that an imbalance in the Th1/Th2 cytokine response, typical for cancer patients, may at least partly be related to soluble factors circulating in the patients' blood. We discuss a putative role of serum IL-10, IL-1ra, and soluble IL-2Ralpha in the effects observed. Topics: Adenocarcinoma; Adult; Aged; Carcinoma, Large Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Concanavalin A; Cytokines; Female; Humans; Interleukin-2 Receptor alpha Subunit; Lung Neoplasms; Male; Middle Aged; Monocytes; Receptors, Interleukin; Receptors, Interleukin-2; Serum | 2004 |