concanavalin-a has been researched along with Bronchial-Neoplasms* in 3 studies
3 other study(ies) available for concanavalin-a and Bronchial-Neoplasms
| Article | Year |
|---|---|
Association of fibroblastoid features with the invasive phenotype in human bronchial cancer cell lines.
The acquisition of a metastatic phenotype by epithelial cells implicates a series of changes altering their differentiation, their overall behavior and morphology. In the present study, we have examined the relationships between the cellular morphology, E-cadherin expression, matrix metalloproteinases expression and in vitro invasive properties in two human bronchial immortalized cell lines. The (16HBE14o-) cell line which did not show any invasive abilities in the Boyden chamber assay displayed a typical epithelial morphology in monolayer, expressed high levels of E-cadherin and synthesized neither MMP-2 and MT1-MMP nor vimentin. In contrast, the BZR cell line which was highly invasive displayed a more elongated phenotype in monolayer, did not produce E-cadherin but expressed vimentin, MMP-2 and MT1-MMP. Our data therefore suggest that the metastatic progression of broncho-pulmonary cancer cells results in a cellular dedifferentiation and the gain of some mesenchymal attributes (loss of E-cadherin and expression of vimentin) associated with enhanced degradative properties (expression of metalloproteinases). Topics: Bronchial Neoplasms; Cadherins; Concanavalin A; Culture Media, Conditioned; Culture Media, Serum-Free; Enzyme Activation; Enzyme Induction; Gelatinases; Humans; In Vitro Techniques; Matrix Metalloproteinase 2; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Neoplasm Invasiveness; Tumor Cells, Cultured; Vimentin | 1998 |
Spontaneous transformation of human fibroblast cultures derived from bronchial carcinomata.
Topics: Agglutination; Bronchial Neoplasms; Cell Transformation, Neoplastic; Cells, Cultured; Chromosomes; Concanavalin A; Fibroblasts; Humans; Male; Middle Aged; Mitosis | 1976 |
Lymphocyte sensitization to basic protein of brain in malignant neoplasia: experiments with serotonin and related compounds.
Topics: Acetylcholine; Adult; Brain; Brain Chemistry; Breast Neoplasms; Bronchial Neoplasms; Carcinoma; Cell Migration Inhibition; Concanavalin A; Epinephrine; Epitopes; Female; Histamine; Humans; Laryngeal Neoplasms; Lymphocytes; Macrophages; Male; Middle Aged; Myasthenia Gravis; Neoplasm Proteins; Neoplasms; Nerve Tissue Proteins; Norepinephrine; Sarcoidosis; Serotonin; Stomach Neoplasms; Succinylcholine; Tryptamines | 1971 |