concanavalin-a has been researched along with Anemia--Hemolytic--Autoimmune* in 3 studies
3 other study(ies) available for concanavalin-a and Anemia--Hemolytic--Autoimmune
| Article | Year |
|---|---|
Abnormal generation of concanavalin A-induced suppressor cell function in human autoimmune hemolytic anemia.
Topics: Anemia, Hemolytic, Autoimmune; Concanavalin A; Dose-Response Relationship, Immunologic; Female; Humans; Immunity, Cellular; Lymphocyte Activation; Male; Phytohemagglutinins; Pokeweed Mitogens; T-Lymphocytes, Regulatory | 1982 |
Specific and non-specific suppressor cell activity in NZB mice.
Non-specific and specific suppressor cell activity has been examined in both young and old NZB mice and compared to normal CBA mice. Both young and old NZB mice are shown to be able to generate antigen non-specific and specific suppressor cells in response to Con A and rat RBC respectively. In addition, antigen-specific suppressor cells which suppress the experimental induction of red cell autoantibodies do not influence the spontaneous development or course of autoimmune haemolytic anaemia. Subsequent experiments showed that this is probably due to differences in specificity of induced and spontaneous autoantibodies. Topics: Aging; Anemia, Hemolytic, Autoimmune; Animals; Antibody Specificity; Autoantibodies; Concanavalin A; Epitopes; Erythrocytes; Mice; Mice, Inbred CBA; Mice, Inbred NZB; T-Lymphocytes, Regulatory | 1980 |
Functional and surface characterisitics of lymphocytes from patients with warm-antibody type autoimmunhemolytic anemia (AIHA).
As part of an overall assessment of immunological function, several aspects of cellular immunity and circulating lymphocyte subpopulations were evaluated in a group of 10 patients with idiopathic autoimmunhemolytic anemia (AIHA). The absolute numbers of circulating T and B cells were reduced in the patient group compared to normals. A shift from "corticosteroid-sensitive" to "corticosteroid-resistent" and activated cells in the cytogram of clustered Fe-(III)-hydroxide-glucane saccharose labeled T lymphocytes was apparent. In vitro studies of cellular reactivity, as evaluated by PHA, ConA, PWM, antigens and allogeneic cell induced proliferation showed a blend of general or selective depression and sometimes a normal or increased activity with no definite correlation with both the number of circulating T cells and the extent of the hemolytic activity by the disease. The possible significance of the findings is discussed. Topics: Anemia, Hemolytic, Autoimmune; Animals; Antibodies; Antibody-Producing Cells; B-Lymphocytes; Cell Division; Concanavalin A; Immunity, Cellular; Mice; Mice, Inbred NZB; Rosette Formation; Surface Properties; T-Lymphocytes | 1978 |