concanamycin-a has been researched along with Dengue* in 1 studies
1 other study(ies) available for concanamycin-a and Dengue
| Article | Year |
|---|---|
Blockade of dengue virus infection and viral cytotoxicity in neuronal cells in vitro and in vivo by targeting endocytic pathways.
Dengue virus (DENV) infection in neuronal cells was speculated to trigger neuropathy. Herein, we determined the blockade of DENV infection by targeting endocytic pathways in vitro and in vivo. In DENV-infected mouse brains, we previously showed that viral proteins are expressed in neuronal cells around the hippocampus with accompanying neurotoxicity. DENV caused infection, including entry, double-stranded (ds)RNA replication, protein expression, and virus release, followed by cytotoxicity in the mouse neuronal Neuro-2a cell line. Pharmacologically blocking clathrin-mediated endocytosis of the DENV retarded viral replication. Targeting vacuolar-type H Topics: Animals; Antifungal Agents; Cell Line; Cell Survival; Clathrin; Dengue; Dengue Virus; Disease Models, Animal; Endocytosis; Humans; In Vitro Techniques; Macrolides; Mice; Neurons; Virus Internalization; Virus Replication | 2017 |