conantokin-t has been researched along with Morphine-Dependence* in 2 studies
2 other study(ies) available for conantokin-t and Morphine-Dependence
| Article | Year |
|---|---|
A Conantokin Peptide Con-T[M8Q] Inhibits Morphine Dependence with High Potency and Low Side Effects.
Topics: Animals; Conotoxins; Disease Models, Animal; Excitatory Amino Acid Antagonists; Hippocampus; Locomotion; Male; Mice; Morphine Dependence; Naloxone; Piperidines; Receptors, N-Methyl-D-Aspartate; Spatial Memory | 2021 |
Conantokins and variants derived from cone snail venom inhibit naloxone-induced withdrawal jumping in morphine-dependent mice.
The biochemical processes underlying opiate addiction are complex, but n-methyl-d-aspartate receptor (NMDAR) dysfunction appears to be one contributing factor. NMDAR antagonists, including MK-801 and memantine, have previously been shown to assuage symptoms stemming from opiate withdrawal. The conantokins are a small family of naturally occurring peptide toxins known to specifically antagonize the NMDAR. In the present study, the effects of wild-type and variant conantokins on the suppression of naloxone-induced jumping in morphine-dependent mice were evaluated. Our results demonstrate that NR2B-selective conantokins, viz., con-G, con-G[S(16)Y] and con-G[gamma(7)K], are potent inhibitors of naloxone-induced jumping at low doses (2-15 nmol/kg) compared with con-T, con-R[1-17], and small-molecule antagonists of the NMDAR, including the NR2B-selective agent, ifenprodil. We conclude that the NR2B-selective conantokins may find utility as neuropharmacological tools for probing NMDAR-related mechanisms of opiate dependence. Topics: Animals; Conotoxins; Intercellular Signaling Peptides and Proteins; Male; Mice; Mollusk Venoms; Morphine Dependence; Naloxone; Narcotic Antagonists; Peptides; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Substance Withdrawal Syndrome | 2006 |