Page last updated: 2024-08-26

combretastatin and Neoplasms

combretastatin has been researched along with Neoplasms in 51 studies

Research

Studies (51)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's19 (37.25)29.6817
2010's27 (52.94)24.3611
2020's5 (9.80)2.80

Authors

AuthorsStudies
Kankala, RK; Kankala, S; Nerella, S; Paidakula, S1
Dosumu, OO; Egharevba, GO; Fadare, OA; Kamal, A; Njinga, SN; Oguntoye, SO; Oluyori, AP; Routhu, S1
Kumar, D; Kumar, S; Sharma, P; Shri, R1
Sherbet, GV2
Fong, WP; Ha, SYY; Ng, DKP; Zhou, Y1
Abdel Hafez, NA; Ali, KA; Amr, AEE; El-Hallouty, SM; El-Shahawi, MM; Elsayed, MA1
Aoshima, K; Hoshino, Y; Izumi, Y; Takagi, S1
Bernasconi, L; Bisby, RH; Holzmann, N; Parker, AW1
Carda, M; Conesa-Milián, L; Falomir, E; Marco, JA; Murga, J1
Alam, MM; Kamal, A; Marella, A; Nainwal, LM; Shaquiquzzaman, M1
Lipeeva, AV; Pokrovsky, AG; Pokrovsky, MA; Shakirov, MM; Shults, EE1
Bao, K; Guan, Q; Guo, D; Jiang, M; Liu, C; Wu, Y; Xu, J; Yang, F; Zhang, W1
Alberto Marco, J; Carda, M; Díaz-Oltra, S; Falomir, E; Murga, J; Torijano-Gutiérrez, S; Vilanova, C1
Dall'Acqua, S1
Dai, XL; Jiang, KM; Jin, Y; Li, K; Lin, J; Wu, D; Zhang, JH1
Abma, E; Daminet, S; de Rooster, H; Ni, Y; Smets, P1
Chaplin, DJ; Chen, Z; Devkota, L; Guddneppanavar, R; Hamel, E; Jelinek, CJ; Lin, CM; Liu, L; Lopez, R; Mason, RP; Pinney, KG; Strecker, TE; Tidmore, JK; Trawick, ML; Wang, Y1
Chen, M; Li, X; Luo, X; Wei, J; Xu, G; Zhang, H1
Bedi, PM; Gupta, MK; Saxena, AK; Sharma, S1
Giacomini, E; Guidotti, L; Recanatini, M; Roberti, M; Rupiani, S1
Bueno, O; Canela, MD; Liekens, S; Martins, MS; Pérez-Pérez, MJ; Priego, EM1
Gevertz, JL1
Diao, PC; Li, Q; Li, YH; Yang, HK; You, WW; Zhang, B; Zhao, PL1
Franken, A; Grohmann, NC; Hall, JJ; Pinney, KG; Sriram, M; Strecker, TE; Trawick, ML; Wootton, T1
Kanthou, C; Tozer, GM1
Hori, K; Nishihara, M; Shiraishi, K; Yokoyama, M1
Cai, YC; Xian, LJ; Zou, Y1
Haselwandter, CA; Kardar, M; Kohandel, M; Sengupta, S; Sivaloganathan, S1
Lenihan, DJ; Subbiah, IM; Tsimberidou, AM1
Babu, B; Bandi, RK; Behera, AK; Brockway, O; Lee, M; Mishra, BK; Mooberry, SL; Pati, H; Satam, V; Tzou, S; Westbrook, C; Zeller, M1
Harada, Y; Hori, K; Kawano, K; Maitani, Y; Shiraishi, K; Takigahira, M; Yanagihara, K; Yokoyama, M1
Hori, K1
Barsoum, J; Borella, C; Foley, KP; Jiang, J; Korbut, T; Li, H; Sang, J; Sonderfan, AJ; Wu, Y; Ye, J; Zhang, M; Zhang, X; Zhou, D1
Prinz, H1
Collins, JM1
Anderson, H; Folkes, LK; Galbraith, SM; Gumbrell, L; Price, PM; Rustin, GJ; Sena, L; Stratford, M1
Mariani, SM1
Cavanaugh, SX; Hammond, LA; Thomas, CR1
Kiziltepe, T; Sasisekharan, R; Sengupta, S1
Baguley, BC; Kanthou, C; Tozer, GM1
Mooney, D1
Capila, I; Eavarone, D; Kiziltepe, T; Sasisekharan, R; Sengupta, S; Watson, N; Zhao, G1
Ackley, JF; Edvardsen, K; Garner, CM; Hadimani, MB; Monk, KA; Mugabe, BE; Pettit, GR; Pinney, KG; Rhodes, MR; Siles, R; Studerus, SW; Trawick, ML1
Martin, S1
Byung-Zun, A; Nam, NH1
Ackley, JF; Chaplin, DJ; Chapuis, JC; Edvardsen, K; Garner, CM; Guddneppanavar, R; Hadimani, MB; Hall, JJ; Monk, KA; Mugabe, BE; Pettit, GR; Pinney, KG; Siles, R; Trawick, ML1
Randal, J1
Bailly, C; Lansiaux, A; Verdier-Pinard, P1
Bentzen, S; Galbraith, SM; Lodge, MA; Padhani, AR; Rustin, GJ; Stirling, JJ; Taylor, NJ1
Hill, SA; Kanthou, C; Parkins, CS; Tozer, GM1

Reviews

16 review(s) available for combretastatin and Neoplasms

ArticleYear
Recent Trends in Tubulin-Binding Combretastatin A-4 Analogs for Anticancer Drug Development.
    Current medicinal chemistry, 2022, Volume: 29, Issue:21

    Topics: Antineoplastic Agents; Bibenzyls; Cell Line, Tumor; Cell Proliferation; Drug Design; Humans; Neoplasms; Stilbenes; Structure-Activity Relationship; Tubulin; Tubulin Modulators

2022
Mechanistic Insights and Docking Studies of Phytomolecules as Potential Candidates in the Management of Cancer.
    Current pharmaceutical design, 2022, Volume: 28, Issue:33

    Topics: Antineoplastic Agents; Bibenzyls; Colchicine; Curcumin; Humans; Molecular Docking Simulation; Neoplasms; Paclitaxel

2022
Combretastatin analogues in cancer biology: A prospective view.
    Journal of cellular biochemistry, 2020, Volume: 121, Issue:3

    Topics: Animals; Antineoplastic Agents, Phytogenic; Bibenzyls; Gene Expression Regulation, Neoplastic; Humans; Neoplasms

2020
Synthesis, Anticancer Screening and Molecular Docking Studies of New Heterocycles with Trimethoxyphenyl Scaffold as Combretastatin Analogues.
    Mini reviews in medicinal chemistry, 2018, Volume: 18, Issue:8

    Topics: Antineoplastic Agents; Bibenzyls; Binding Sites; Cell Survival; Heterocyclic Compounds; Humans; Neoplasms; Pyrazoles; Pyridines; Pyrimidines; Structure-Activity Relationship

2018
Suppression of angiogenesis and tumour progression by combretastatin and derivatives.
    Cancer letters, 2017, 09-10, Volume: 403

    Topics: Angiogenesis Inhibitors; Animals; Bibenzyls; Cell Movement; Cell Proliferation; Disease Progression; Epithelial-Mesenchymal Transition; Humans; Neoplasm Invasiveness; Neoplasms; Neovascularization, Pathologic; Signal Transduction; Tumor Burden

2017
Combretastatin-based compounds with therapeutic characteristics: a patent review.
    Expert opinion on therapeutic patents, 2019, Volume: 29, Issue:9

    Topics: Animals; Antineoplastic Agents, Phytogenic; Bibenzyls; Drug Design; Humans; Neoplasms; Patents as Topic; Solubility; Structure-Activity Relationship; Tubulin Modulators

2019
Natural products as antimitotic agents.
    Current topics in medicinal chemistry, 2014, Volume: 14, Issue:20

    Topics: Antimitotic Agents; Antineoplastic Agents; Bibenzyls; Biological Products; Humans; Ligands; Microtubules; Neoplasms; Paclitaxel; Protein Binding; Structure-Activity Relationship; Tubulin; Vinca Alkaloids

2014
Combretastatin A4-phosphate and its potential in veterinary oncology: a review.
    Veterinary and comparative oncology, 2017, Volume: 15, Issue:1

    Topics: Animals; Antineoplastic Agents, Phytogenic; Bibenzyls; Dog Diseases; Dogs; Humans; Medical Oncology; Mice; Neoplasms; Neovascularization, Pathologic; Veterinary Medicine

2017
The Use of Stilbene Scaffold in Medicinal Chemistry and Multi- Target Drug Design.
    Current medicinal chemistry, 2016, Volume: 23, Issue:23

    Topics: Alzheimer Disease; Antineoplastic Agents, Phytogenic; Bibenzyls; Chemistry, Pharmaceutical; Drug Design; Humans; Neoplasms; Resveratrol; Stilbenes; Structure-Activity Relationship

2016
Microtubule depolymerizing vascular disrupting agents: novel therapeutic agents for oncology and other pathologies.
    International journal of experimental pathology, 2009, Volume: 90, Issue:3

    Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Bibenzyls; Drug Resistance, Neoplasm; Humans; Neoplasms; Neovascularization, Pathologic; Tubulin Modulators

2009
[Advances in the study of the anti-tumor activity of small molecule vascular disrupting agents].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2010, Volume: 45, Issue:3

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Bibenzyls; Diphosphates; Endothelial Cells; Humans; Molecular Structure; Neoplasms; Neovascularization, Pathologic; Oligopeptides; Organophosphorus Compounds; Serine; Stilbenes; Tubulin Modulators; Xanthones

2010
Starvation tactics for solid tumors: tumor blood flow interruption via a combretastatin derivative (Cderiv), and its microcirculation mechanism.
    Cancer metastasis reviews, 2012, Volume: 31, Issue:1-2

    Topics: Animals; Antineoplastic Agents, Phytogenic; Bibenzyls; Humans; Microcirculation; Necrosis; Neoplasms

2012
Recent advances in the field of tubulin polymerization inhibitors.
    Expert review of anticancer therapy, 2002, Volume: 2, Issue:6

    Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Bibenzyls; Biological Factors; Drug Design; Humans; Neoplasms; Protein Binding; Stilbenes; Tubulin; Tubulin Modulators

2002
Disrupting tumour blood vessels.
    Nature reviews. Cancer, 2005, Volume: 5, Issue:6

    Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Bibenzyls; Capillary Permeability; Clinical Trials as Topic; Endothelial Cells; Humans; Neoplasms; Neovascularization, Pathologic; Stilbenes; Xanthones

2005
[Combretastatin A4 phosphate].
    Bulletin du cancer, 2001, Volume: 88, Issue:3

    Topics: Animals; Antineoplastic Agents, Phytogenic; Bibenzyls; Clinical Trials as Topic; Drug Evaluation, Preclinical; Humans; Mice; Neoplasms; Neovascularization, Pathologic; Quantitative Structure-Activity Relationship; Rats; Stilbenes; Transplantation, Heterologous

2001
The biology of the combretastatins as tumour vascular targeting agents.
    International journal of experimental pathology, 2002, Volume: 83, Issue:1

    Topics: Animals; Antineoplastic Agents, Phytogenic; Bibenzyls; Endothelium, Vascular; Humans; Neoplasms; Neovascularization, Pathologic; Stilbenes

2002

Trials

1 trial(s) available for combretastatin and Neoplasms

ArticleYear
Phase I clinical trial of weekly combretastatin A4 phosphate: clinical and pharmacokinetic results.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Aug-01, Volume: 21, Issue:15

    Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Area Under Curve; Bibenzyls; Chromatography, High Pressure Liquid; Drug Administration Schedule; Female; Humans; Infusion Pumps; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasms; Statistics, Nonparametric; Stilbenes; Tomography, Emission-Computed; Treatment Outcome

2003

Other Studies

34 other study(ies) available for combretastatin and Neoplasms

ArticleYear
Synthesis and characterization of novel combretastatin analogues of 1,1-diaryl vinyl sulfones, with antiproliferative potential via in-silico and in-vitro studies.
    Scientific reports, 2022, 02-03, Volume: 12, Issue:1

    Topics: A549 Cells; Antineoplastic Agents, Phytogenic; Bibenzyls; Cell Proliferation; Dose-Response Relationship, Drug; HEK293 Cells; HeLa Cells; Humans; Inhibitory Concentration 50; Molecular Docking Simulation; Molecular Structure; Neoplasms; Permeability; Structure-Activity Relationship; Sulfones

2022
Multifunctional Molecular Therapeutic Agent for Targeted and Controlled Dual Chemo- and Photodynamic Therapy.
    Journal of medicinal chemistry, 2020, 08-13, Volume: 63, Issue:15

    Topics: Antineoplastic Agents; Benzenesulfonates; Bibenzyls; Drug Delivery Systems; Glutathione; HCT116 Cells; Hep G2 Cells; Humans; Indoles; Isoindoles; Neoplasms; Organometallic Compounds; Photochemotherapy; Photosensitizing Agents; Prodrugs; Zinc Compounds

2020
Effects of combretastatin A-4 phosphate on canine normal and tumor tissue-derived endothelial cells.
    Research in veterinary science, 2017, Volume: 112

    Topics: Animals; Bibenzyls; Cells, Cultured; Dogs; Endothelial Cells; Endothelium, Vascular; Humans; Neoplasms; Neovascularization, Pathologic; Phosphates; Stilbenes

2017
Influence of charge transfer on the isomerisation of stilbene derivatives for application in cancer therapy.
    Physical chemistry chemical physics : PCCP, 2018, Nov-14, Volume: 20, Issue:44

    Topics: Antineoplastic Agents; Bibenzyls; Humans; Isomerism; Light; Models, Molecular; Molecular Structure; Neoplasms; Photochemical Processes; Stilbenes; Structure-Activity Relationship; Thermodynamics

2018
Novel multitarget inhibitors with antiangiogenic and immunomodulator properties.
    European journal of medicinal chemistry, 2019, May-15, Volume: 170

    Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Bibenzyls; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; HEK293 Cells; Humans; Immunologic Factors; Molecular Docking Simulation; Neoplasms; Protein Kinase Inhibitors; Urea; Vascular Endothelial Growth Factor Receptor-2

2019
Synthesis and cytotoxic activity of a new group of heterocyclic analogues of the combretastatins.
    Molecules (Basel, Switzerland), 2014, Jun-11, Volume: 19, Issue:6

    Topics: Antineoplastic Agents, Phytogenic; Bibenzyls; Cell Line, Tumor; Coumarins; Drug Screening Assays, Antitumor; Ficusin; Furocoumarins; Humans; Molecular Structure; Neoplasms; Stilbenes; Structure-Activity Relationship; Tubulin Modulators

2014
Synthesis and biological evaluation of novel 3,4-diaryl-1,2,5-selenadiazol analogues of combretastatin A-4.
    European journal of medicinal chemistry, 2014, Nov-24, Volume: 87

    Topics: Antineoplastic Agents, Phytogenic; Bibenzyls; Cell Cycle; Cell Proliferation; Drug Screening Assays, Antitumor; Flow Cytometry; Fluorescent Antibody Technique; Heterocyclic Compounds; Humans; Models, Molecular; Molecular Structure; Neoplasms; Selenium; Stilbenes; Structure-Activity Relationship; Tumor Cells, Cultured

2014
Design and synthesis of pironetin analogue/combretastatin A-4 hybrids containing a 1,2,3-triazole ring and evaluation of their cytotoxic activity.
    European journal of medicinal chemistry, 2014, Nov-24, Volume: 87

    Topics: Antineoplastic Agents, Phytogenic; Bibenzyls; Cell Proliferation; Cells, Cultured; Drug Design; Drug Screening Assays, Antitumor; Flow Cytometry; HEK293 Cells; Humans; Molecular Structure; Neoplasms; Pyrones; Structure-Activity Relationship; Triazoles

2014
Synthesis and In-Vitro Cytotoxicity of (E)-N,2,3-Triarylacrylamide Derivatives as Analogs of Combretastatin A-4.
    Medicinal chemistry (Shariqah (United Arab Emirates)), 2015, Volume: 11, Issue:5

    Topics: Antineoplastic Agents; Bibenzyls; Cell Line, Tumor; Cell Survival; Crystallography, X-Ray; Humans; Neoplasms; Structure-Activity Relationship

2015
Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents.
    Bioorganic & medicinal chemistry, 2016, Mar-01, Volume: 24, Issue:5

    Topics: Amino Acids; Animals; Antineoplastic Agents; Bibenzyls; Breast; Breast Neoplasms; Cell Line, Tumor; Coumarins; Drug Design; Female; Humans; Mice; Mice, SCID; Naphthalenes; Neoplasms; Optical Imaging; Prodrugs; Solubility; Structure-Activity Relationship; Tubulin; Water

2016
Tunable release of chemotherapeutic and vascular disrupting agents from injectable fiber fragments potentiates combination chemotherapy.
    International journal of pharmaceutics, 2016, Jun-15, Volume: 506, Issue:1-2

    Topics: 2-Hydroxypropyl-beta-cyclodextrin; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; beta-Cyclodextrins; Bibenzyls; Camptothecin; Cell Line, Tumor; Cell Proliferation; Drug Liberation; Drug Therapy, Combination; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mice, Inbred BALB C; Neoplasms; Tumor Microenvironment

2016
Thiazolidinone Constraint Combretastatin Analogs as Novel Antitubulin Agents: Design, Synthesis, Biological Evaluation and Docking Studies.
    Anti-cancer agents in medicinal chemistry, 2017, Volume: 17, Issue:2

    Topics: Antineoplastic Agents; Bibenzyls; Cell Line, Tumor; Cell Survival; Crystallography, X-Ray; Drug Design; Drug Screening Assays, Antitumor; Humans; Molecular Docking Simulation; Neoplasms; Structure-Activity Relationship; Thiazolidinediones; Tubulin; Tubulin Modulators

2017
Blocking Blood Flow to Solid Tumors by Destabilizing Tubulin: An Approach to Targeting Tumor Growth.
    Journal of medicinal chemistry, 2016, 10-13, Volume: 59, Issue:19

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Phytogenic; Bibenzyls; Drug Discovery; Hemodynamics; Humans; Models, Molecular; Neoplasms; Neovascularization, Pathologic; Tubulin; Tubulin Modulators

2016
Microenvironment-Mediated Modeling of Tumor Response to Vascular-Targeting Drugs.
    Advances in experimental medicine and biology, 2016, Volume: 936

    Topics: Angiogenesis Inhibitors; Bevacizumab; Bibenzyls; Computer Simulation; Cytotoxins; Drug Combinations; Drug Dosage Calculations; Endothelial Cells; Everolimus; Humans; Models, Statistical; Neoplasms; Neovascularization, Pathologic; Tumor Microenvironment; Xanthones

2016
Design, synthesis, and biological evaluation of novel alkylsulfanyl-1,2,4-triazoles as cis-restricted combretastatin A-4 analogues.
    European journal of medicinal chemistry, 2017, Jan-05, Volume: 125

    Topics: Antineoplastic Agents; Bibenzyls; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Neoplasms; Stereoisomerism; Structure-Activity Relationship; Triazoles

2017
Design, synthesis and biological evaluation of dihydronaphthalene and benzosuberene analogs of the combretastatins as inhibitors of tubulin polymerization in cancer chemotherapy.
    Bioorganic & medicinal chemistry, 2008, Sep-01, Volume: 16, Issue:17

    Topics: Antineoplastic Agents; Benzocycloheptenes; Bibenzyls; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Molecular Structure; Naphthalenes; Neoplasms; Stereoisomerism; Structure-Activity Relationship; Tubulin

2008
The combretastatin derivative (Cderiv), a vascular disrupting agent, enables polymeric nanomicelles to accumulate in microtumors.
    Journal of pharmaceutical sciences, 2010, Volume: 99, Issue:6

    Topics: Animals; Antineoplastic Agents; Bibenzyls; Blood Vessels; Fluorescein; Fluorescein-5-isothiocyanate; Hemodynamics; Male; Neoplasms; Oxides; Polymers; Rats; Serum Albumin

2010
Quantitative model for efficient temporal targeting of tumor cells and neovasculature.
    Computational and mathematical methods in medicine, 2011, Volume: 2011

    Topics: Algorithms; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bibenzyls; Biological Availability; Carcinoma, Lewis Lung; Computer Simulation; Doxorubicin; Drug Delivery Systems; Drug Synergism; Liposomes; Melanoma, Experimental; Mice; Models, Biological; Nanoparticles; Neoplasms; Neovascularization, Pathologic; Time Factors; Treatment Outcome

2011
Cardiovascular toxicity profiles of vascular-disrupting agents.
    The oncologist, 2011, Volume: 16, Issue:8

    Topics: Angiogenesis Inhibitors; Bibenzyls; Cardiovascular System; Clinical Trials as Topic; Humans; Neoplasms; Neovascularization, Pathologic; Organophosphorus Compounds; Quinazolines; Serine; Xanthones

2011
Design, synthesis, and cytotoxicity of novel 3-arylidenones derived from alicyclic ketones.
    Chemical biology & drug design, 2011, Volume: 78, Issue:4

    Topics: Animals; Antineoplastic Agents; Bibenzyls; Cell Line, Tumor; Cell Survival; Chalcones; Drug Design; Humans; Ketones; Mice; Models, Molecular; Neoplasms; Stilbenes; Structure-Activity Relationship; Tubulin Modulators

2011
Tumor environment changed by combretastatin derivative (Cderiv) pretreatment that leads to effective tumor targeting, MRI studies, and antitumor activity of polymeric micelle carrier systems.
    Pharmaceutical research, 2012, Volume: 29, Issue:1

    Topics: Animals; Antibiotics, Antineoplastic; Bibenzyls; Capillary Permeability; Doxorubicin; Drug Carriers; Female; Humans; Magnetic Resonance Imaging; Mice; Mice, Inbred BALB C; Micelles; Neoplasms; Tumor Microenvironment

2012
The vascular disrupting agent STA-9584 exhibits potent antitumor activity by selectively targeting microvasculature at both the center and periphery of tumors.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 343, Issue:2

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Bibenzyls; Cell Survival; Dogs; Female; Heart; Hemodynamics; Human Umbilical Vein Endothelial Cells; Humans; In Vitro Techniques; Isoxazoles; Male; Mice; Mice, Inbred BALB C; Mice, SCID; Microcirculation; Neoplasms; Neovascularization, Pathologic; Phenylalanine; Rabbits; Regional Blood Flow; Tubulin Modulators; Xenograft Model Antitumor Assays

2012
Functional imaging in phase I studies: decorations or decision making?
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003, Aug-01, Volume: 21, Issue:15

    Topics: Animals; Antineoplastic Agents, Phytogenic; Bibenzyls; Clinical Trials, Phase I as Topic; Decision Making; Humans; Magnetic Resonance Imaging; Neoplasms; Rats; Stilbenes; Tomography, Emission-Computed

2003
Anti-angiogenesis: the challenges ahead.
    MedGenMed : Medscape general medicine, 2003, Apr-30, Volume: 5, Issue:2

    Topics: Angiogenesis Inhibitors; Angiogenic Proteins; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Phytogenic; Bevacizumab; Bibenzyls; Biological Availability; Biomarkers; Carcinoma, Renal Cell; Clinical Trials as Topic; Combined Modality Therapy; Drug Resistance, Neoplasm; Endostatins; Endothelial Growth Factors; Endothelium, Vascular; Growth Inhibitors; Humans; Kidney Neoplasms; Microtubules; Neoplasms; Neovascularization, Pathologic; Ontario; Receptors, Vascular Endothelial Growth Factor; Stilbenes

2003
An image worth a thousand lives?
    Nature biotechnology, 2004, Volume: 22, Issue:6

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Benzoquinones; Bibenzyls; Diagnostic Imaging; Down-Regulation; ErbB Receptors; Gefitinib; Heterocyclic Compounds, 1-Ring; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Magnetic Resonance Imaging; Molecular Probe Techniques; Mutation; Neoplasms; Phthalazines; Physiological Phenomena; Positron-Emission Tomography; Protein Binding; Protein Kinase Inhibitors; Pyridines; Quinazolines; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Receptors, Vascular Endothelial Growth Factor; Rifabutin; Stilbenes; Tissue Distribution; Trastuzumab

2004
A dual-color fluorescence imaging-based system for the dissection of antiangiogenic and chemotherapeutic activity of molecules.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004, Volume: 18, Issue:13

    Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Bibenzyls; Cell Line, Tumor; Coculture Techniques; Doxorubicin; Extracellular Matrix; Fluorescence; Hepatocyte Growth Factor; Humans; Melanoma; Neoplasms; Neovascularization, Pathologic; Phthalazines; Pyridines; Stilbenes; Thalidomide; Vascular Endothelial Growth Factor A

2004
Cancer: one step at a time.
    Nature, 2005, Jul-28, Volume: 436, Issue:7050

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Bibenzyls; Doxorubicin; Drug Delivery Systems; Drug Therapy, Combination; Humans; Mice; Nanotechnology; Neoplasms; Neovascularization, Pathologic; Stilbenes; Time Factors

2005
Temporal targeting of tumour cells and neovasculature with a nanoscale delivery system.
    Nature, 2005, Jul-28, Volume: 436, Issue:7050

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Bibenzyls; Carcinoma, Lewis Lung; Coculture Techniques; Doxorubicin; Drug Delivery Systems; Drug Therapy, Combination; Endothelial Cells; Humans; Melanoma, Experimental; Mice; Nanotechnology; Neoplasms; Neovascularization, Pathologic; Stilbenes; Time Factors; Tissue Distribution

2005
Design, synthesis, and biological evaluation of combretastatin nitrogen-containing derivatives as inhibitors of tubulin assembly and vascular disrupting agents.
    Bioorganic & medicinal chemistry, 2006, May-01, Volume: 14, Issue:9

    Topics: Animals; Benzaldehydes; Bibenzyls; Cattle; Cell Proliferation; Drug Design; Isomerism; Mice; Molecular Structure; Neoplasms; Regional Blood Flow; Stilbenes; Structure-Activity Relationship; Tubulin; Xenograft Model Antitumor Assays

2006
New Agents in Clinical Oncology. 24 November 2006, London, UK.
    IDrugs : the investigational drugs journal, 2007, Volume: 10, Issue:2

    Topics: 3-Iodobenzylguanidine; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Bibenzyls; Combined Modality Therapy; Enzyme Inhibitors; Humans; Medical Oncology; Neoplasms; Norepinephrine Plasma Membrane Transport Proteins; Poly(ADP-ribose) Polymerase Inhibitors; Proteomics; Stilbenes; Thioredoxins; Topotecan

2007
Combretastatin-chalcone hybrids: synthesis and cytotoxicity.
    Medicinal chemistry (Shariqah (United Arab Emirates)), 2007, Volume: 3, Issue:4

    Topics: Bibenzyls; Cell Line; Cell Survival; Chalcone; Humans; Molecular Structure; Neoplasms; Stilbenes; Structure-Activity Relationship

2007
Combretastatin dinitrogen-substituted stilbene analogues as tubulin-binding and vascular-disrupting agents.
    Journal of natural products, 2008, Volume: 71, Issue:3

    Topics: Animals; Antineoplastic Agents; Bibenzyls; Disease Models, Animal; Drug Design; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Leukemia P388; Mice; Molecular Structure; Neoplasms; Regional Blood Flow; Stilbenes; Tubulin

2008
Antiangiogenesis drugs target specific cancers, mechanisms.
    Journal of the National Cancer Institute, 2000, Apr-05, Volume: 92, Issue:7

    Topics: Angiostatins; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Bibenzyls; Humans; Matrix Metalloproteinase Inhibitors; Neoplasms; Neovascularization, Pathologic; Peptide Fragments; Plasminogen; Stilbenes

2000
Reproducibility of dynamic contrast-enhanced MRI in human muscle and tumours: comparison of quantitative and semi-quantitative analysis.
    NMR in biomedicine, 2002, Volume: 15, Issue:2

    Topics: Antineoplastic Agents; Bibenzyls; Contrast Media; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Muscle, Skeletal; Neoplasms; Reproducibility of Results; Stilbenes; Xanthenes; Xanthones

2002