colistin and Tuberculosis--Multidrug-Resistant

colistin has been researched along with Tuberculosis--Multidrug-Resistant* in 2 studies

Other Studies

2 other study(ies) available for colistin and Tuberculosis--Multidrug-Resistant

ArticleYear
In vivo bactericidal effect of colistin-linezolid combination in a murine model of MDR and XDR Acinetobacter baumannii pneumonia.
    Scientific reports, 2020, 10-15, Volume: 10, Issue:1

    Recently, paradoxical combinations of colistin with anti-Gram-positive bacterial agents were introduced as a treatment alternative for multidrug-resistant Acinetobacter baumannii (MDRAB) infection. We assessed the therapeutic efficacy of the colistin-linezolid combination regimen in vitro and in a murine model of Acinetobacter baumannii pneumonia. A multidrug-resistant clinical strain (MDRAB31) and an extensively drug-resistant clinical strain (XDRAB78) were used in this study. The survival rates of mice and bacterial counts in lung tissue were used to assess the effects of colistin-linezolid combination. The survival rates of colistin-linezolid combination groups significantly increased compared with colistin groups for MDRAB31 (72% versus 32%, P = 0.03) and for XDRAB78 (92% versus 68%, P = 0.031). The colistin-linezolid combination groups significantly reduced the bacterial counts in lung tissue compared with colistin groups for MDRAB31 and for XDRAB78 (P < 0.05). The colistin-linezolid combination had a bactericidal and synergistic effect compared with colistin alone in time-kill assay and in murine model of pneumonia. Our data demonstrated the synergistic effect of colistin-linezolid combination regimen as a treatment alternative for the severe pulmonary infection caused by MDRAB and XDRAB.

    Topics: Acinetobacter baumannii; Acinetobacter Infections; Animals; Antitubercular Agents; Colistin; Disease Models, Animal; Drug Synergism; Extensively Drug-Resistant Tuberculosis; Female; Linezolid; Lung; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Pneumonia, Bacterial; Time Factors; Tuberculosis, Multidrug-Resistant

2020
Editorial: the resurrection of old antibiotics.
    International journal of antimicrobial agents, 2017, Volume: 49, Issue:5

    Topics: Anti-Bacterial Agents; Colistin; Drug Resistance, Multiple, Bacterial; Humans; Polymyxin B; Tuberculosis, Multidrug-Resistant

2017