colistin and Skin-Diseases

Norfloxacin has been compared to placebo (136 patients), sulfamethoxazole plus trimethoprim (SXT, 72 patients) and oral vancomycin plus colistin (V/C, 61 patients) for the prevention of alimentary tract-associated infections during and after induction chemotherapy. These patients were evaluated for the safety and tolerability of each regimen by clinical and laboratory means. Most neutropenics involved, regardless of the regimen, experienced at least one adverse experience. The majority were felt to be unrelated to prophylactic study drug therapy. Of 139 patients who received norfloxacin, only two had drug-related adverse experiences, compared to two of 35 receiving SXT, five of 28 for VC, and none of 67 receiving placebo. In evaluating adverse experiences considered possibly drug related, 19 occurred on norfloxacin compared to 13 for placebo. Among neurologic adverse experiences, only one possibly related to norfloxacin occurred (confusion), while three occurred on placebo (confusion, decreased auditory acuity and hallucinations). Generally, no significant differences were seen between any of the regimens except for a higher frequency of diarrhea in those receiving V/C.

Topics: Agranulocytosis; Bacterial Infections; Clinical Trials as Topic; Colistin; Diarrhea; Gastrointestinal Diseases; Humans; Leukemia; Neutropenia; Norfloxacin; Skin Diseases; Sulfamethoxazole; Trimethoprim; Vancomycin

An improved selective broth, colistin, oxolinic acid, Todd Hewitt broth (COTHB) for the isolation of Streptococcus pyogenes and other streptococci from swabs is described. Staphylococci, coryneforms and Gram negative organisms are inhibited in COTHB inoculated with swabs from skin lesions. Streptococcus pyogenes could be detected by a fluorescent antibody method and by the Streptex and Phadebact streptococcal grouping methods after 6 and 24 h incubation. Other streptococci of groups B, C and G, were also detected. Streptex was the most sensitive and specific method for the detection of streptococci of groups A, B, C, and G in this broth. The method detected 78% of these streptococci in COTHB after 6 h incubation and 93% after 24 h incubation. Of the Strep. pyogenes isolated, 82% were detected in the broth by the Streptex method.

Topics: Colistin; Culture Media; Humans; Latex Fixation Tests; Oxolinic Acid; Skin; Skin Diseases; Streptococcus pyogenes

Topics: Adolescent; Biopsy; Child; Colistin; Female; Humans; Kanamycin; Male; Methicillin; Pityriasis; Skin Diseases

Topics: Animals; Bacteria; Colistin; Culture Media; Drug Resistance, Microbial; Gentamicins; Indicator Dilution Techniques; Kanamycin; Mice; Neomycin; Skin Diseases; Streptomycin

Topics: Anti-Bacterial Agents; Colistin; Dermatology; Skin Diseases