colistin and Respiratory-Insufficiency

Topics: Adult; Anti-Bacterial Agents; Coinfection; Colistin; Combined Modality Therapy; Disease Susceptibility; Drug Substitution; Drug Therapy, Combination; Humans; Kidney Failure, Chronic; Male; Muscle Hypotonia; Osteomyelitis; Renal Dialysis; Reoperation; Respiration, Artificial; Respiratory Insufficiency; Shock, Septic; Spinal Dysraphism; Surgical Wound Infection

The revival of polymyxin antibiotics with the advent of multidrug resistant gram-negative bacteria in the recent decade has led to renewed interest in toxicity of this indispensable drug. We report a postoperative case of burst abdomen where colistin was started in view of Pseudomonas organism sensitive to colistin. Subsequently, the patient went into respiratory depression and encephalopathy after starting the treatment. She recovered promptly after stopping the drug.

Topics: Anti-Bacterial Agents; Brain Diseases; Colistin; Female; Humans; Neurotoxicity Syndromes; Pseudomonas; Pseudomonas Infections; Respiratory Insufficiency; Young Adult

The emergence of highly resistant gram-negative pathogens in hospitals around the world has placed emphasis on colistin, a seemingly ancient drug. Respiratory failure from colistin was reported in the years following its release; however, there are no recent reports of colistin-induced respiratory failure. We report a case of intravenous colistin- and, later, inhalational colistin-induced respiratory failure.

Topics: Acinetobacter baumannii; Acinetobacter Infections; Administration, Inhalation; Adult; Anti-Bacterial Agents; Colistin; Drug Resistance, Multiple, Bacterial; Female; Humans; Infusions, Intravenous; Pneumonia, Bacterial; Respiratory Insufficiency

Topics: Acetylcholine; Anesthesia; Anesthetics; Anti-Bacterial Agents; Calcium; Colistin; Humans; Infant; Kanamycin; Male; Middle Aged; Neomycin; Neuromuscular Junction; Paralysis; Polymyxins; Respiratory Insufficiency; Respiratory Paralysis; Streptomycin; Synaptic Vesicles

Topics: Aged; Ampicillin; Carbenicillin; Colistin; Edrophonium; Humans; Male; Medication Errors; Myasthenia Gravis; Neostigmine; Neuromuscular Depolarizing Agents; Primidone; Pseudomonas Infections; Pyridostigmine Bromide; Respiratory Insufficiency; Urinary Tract Infections

Topics: Acute Kidney Injury; Adolescent; Adult; Age Factors; Aged; Apnea; Body Weight; Colistin; Drug Hypersensitivity; Female; Follow-Up Studies; Humans; Kidney Diseases; Kidney Function Tests; Male; Middle Aged; Nausea; Nervous System Diseases; Paresthesia; Pneumonia; Prospective Studies; Pyelonephritis; Respiratory Insufficiency; Sepsis; Sex Factors; Statistics as Topic; Time Factors; Vomiting

Topics: Adult; Aged; Colistin; Female; Humans; Infant; Male; Middle Aged; Neuromuscular Junction; Paralysis; Polymyxins; Positive-Pressure Respiration; Respiratory Insufficiency; Respiratory Paralysis; Spirometry

Topics: Calcium; Colistin; Electromyography; Humans; Hypocalcemia; Kanamycin; Male; Middle Aged; Myasthenia Gravis; Neostigmine; Neuromuscular Nondepolarizing Agents; Paraplegia; Pyelonephritis; Respiratory Insufficiency; Synaptic Transmission

Topics: Anti-Inflammatory Agents; Asthma; Biomedical Research; Bronchitis; Colistin; Heparin; Humans; Injections, Intravenous; Neomycin; Placebos; Pseudomonas Infections; Pulmonary Emphysema; Respiratory Insufficiency; Respiratory Tract Infections

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Colistin; Dermatologic Agents; Humans; Myasthenia Gravis; Respiratory Insufficiency; Respiratory Paralysis