colistin and Otitis-Media

This study was designed to compare the efficacy and safety of gentamicin otic solution versus colistin-neomycin-hydrocortisone otic suspension in the treatment of otorrhoea due to infection. Fifty-five patients (mean age 36.6 +/- 22.1 years) with sixty infected ears with otorrhoea complicating otitis externa, recurrent otitis media with tympanic membrane perforation, or infected mastoid cavities and post-operative tympanoplasties, were treated for 14 days with either an aqueous solution of gentamicin 0.3% or an aqueous suspension of colistin 0.3%, neomycin 0.33% and hydrocortisone 1.0%. The two possible treatments were assigned randomly and the results were assessed double-blind using usual ordinal scales for monitoring the severity of symptoms. Both otic preparations were found to be equally safe in the treatment of otorrhoea due to infection. No side-effects were observed and hearing status was either unchanged or improved. The antibiotic-steroid combination appeared to be more effective in relieving inflammation in a shorter period of time while gentamicin was observed to be more effective in eradicating the infecting organisms.

Topics: Adult; Bacterial Infections; Chronic Disease; Clinical Trials as Topic; Colistin; Double-Blind Method; Gentamicins; Hearing; Humans; Hydrocortisone; Neomycin; Otitis; Otitis Externa; Otitis Media; Tympanoplasty

It is important to be aware of the potential ototoxicity of any drug, vehicle, or antiseptic that is used in the middle ear. Frequently used ear drops (Cortisporin otic suspension, Coly-Mycin S Otic, and VoSoL otic solution) were studied for their ototoxicity. Compound action potentials were measured before and at 1, 2, and 24 hours following drug application on the round window membranes of chinchillas. Each drug was applied for 10 minutes and then was removed by rinsing. The sound pressure in decibels sound pressure level that produced a compound action potential amplitude of 10 microV was defined as the threshold. The change in threshold was interpreted as hearing loss. On the basis of the short-term results at 24 hours following drug application, the ototoxicity of Coly-Mycin was calculated to be twice that of Cortisporin, and the ototoxicity of VoSoL four times that of Cortisporin.

Topics: Acetates; Acetic Acid; Action Potentials; Administration, Topical; Animals; Benzethonium; Chinchilla; Colistin; Disease Models, Animal; Drug Combinations; Hearing Loss, Sensorineural; Hydrocortisone; Neomycin; Otitis Media; Polymyxin B; Propylene Glycols

Topics: Anti-Infective Agents; Cefaclor; Colistin; Drug Combinations; Drug Resistance, Microbial; Humans; Infant; Male; Microbial Sensitivity Tests; Otitis Media; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination

Opportunistic infections of the external auditory canal or the middle ear due to Pseudomonas aeruginosa occurring in patients with low resistance to infection have a 35 percent mortality rate. Once the process extends into the pneumatized temporal bone, eradication becomes more difficult and the mortality rate increases to 72 percent because of the high incidence of involvement of cranial nerves, adjacent intracranial vessels, and meningitis. Treatment is directed towards the underlying condition, administration of systemic carbenicillin and gentamicin, topical colistin therapy, and judicious surgical debridement. Pseudomonas vaccine may be of help. Fifteen cases are presented. Nine follow the pattern of malignant external otitis and six began as a primary acute otitis media.

Topics: Adult; Aged; Carbenicillin; Colistin; Diabetes Mellitus; Female; Gentamicins; Humans; Infant; Male; Mastoiditis; Middle Aged; Otitis Externa; Otitis Media; Pseudomonas aeruginosa; Pseudomonas Infections

Topics: Acute Disease; Age Factors; Ampicillin; Anti-Bacterial Agents; Child, Preschool; Chloramphenicol; Colistin; Erythromycin; Haemophilus; Haemophilus Infections; Humans; Infant; Infant, Newborn; Microbial Sensitivity Tests; Otitis Media; Penicillins; Pneumococcal Infections; Staphylococcal Infections; Staphylococcus; Streptococcal Infections; Streptococcus pneumoniae; Streptococcus pyogenes; Streptomycin; Tetracycline

Topics: Acrylates; Anti-Bacterial Agents; Bacitracin; Chloramphenicol; Chronic Disease; Colistin; Gels; Gentamicins; Humans; Methods; Otitis Media; Postoperative Complications; Tympanoplasty

Topics: Anti-Bacterial Agents; Bacillus; Bacteria; Chloramphenicol; Chlortetracycline; Chronic Disease; Colistin; Corynebacterium; Depression, Chemical; Erythromycin; Erythromycin Ethylsuccinate; Escherichia coli; Humans; Microbial Sensitivity Tests; Nasal Mucosa; Otitis Media; Oxytetracycline; Penicillin Resistance; Penicillins; Proteus; Pseudomonas aeruginosa; Staphylococcus; Streptomycin; Suppuration; Tetracycline

Topics: Acrylates; Animals; Anti-Bacterial Agents; Bacitracin; Biological Assay; Chloramphenicol; Colistin; Diffusion; Gels; Gentamicins; Humans; Otitis Media; Pharmaceutical Vehicles; Polymers; Rats; Time Factors; Tympanoplasty

Topics: Colistin; Humans; Otitis Media

Topics: Adolescent; Aged; Colistin; Female; Humans; Otitis Media; Tympanic Membrane

Topics: Adolescent; Aged; Colistin; Female; Humans; Male; Middle Aged; Otitis Media; Tympanic Membrane

Topics: Cholesteatoma; Colistin; Humans; Mastoid; Otitis Media; Postoperative Complications

Topics: Colistin; Humans; Otitis Media; Postoperative Care

Topics: Colistin; Humans; Otitis Media; Suppuration

Topics: Animals; Anti-Bacterial Agents; Colistin; Ear Canal; Ear Diseases; Eczema; Furunculosis; Humans; Hydrocortisone; Neomycin; Otitis; Otitis Media; Otolaryngology; Postoperative Care; Solvents; Toxicology; Tympanic Membrane

Topics: Adolescent; Adrenal Cortex Hormones; Aluminum; Anti-Bacterial Agents; Antibiotics, Antitubercular; Child; Colistin; Dermatologic Agents; Diagnosis, Differential; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Oils; Otitis Externa; Otitis Media; Sulfonamides

Topics: Child; Colistin; Ear Diseases; Eustachian Tube; Humans; Otitis Externa; Otitis Media

Topics: Anti-Bacterial Agents; Bacteriology; Colistin; Humans; Hydrocortisone; Mastoiditis; Neomycin; Otitis Externa; Otitis Media; Puerto Rico; Solutions; Toxicology

Topics: Colistin; Drug Hypersensitivity; Otitis Media; Prednisolone; Shock; Shock, Septic; Therapeutic Irrigation; Toxicology

Topics: Animals; Anti-Bacterial Agents; Colistin; Furunculosis; Otitis Media; Urinary Tract Infections

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Colistin; Gastrointestinal Diseases; Humans; Otitis Media; Urinary Tract Infections