colistin and Nervous-System-Diseases

Commonly used antibacterial agents may be associated with various neurotoxic reactions. Central nervous system toxicities include seizure disorders, encephalopathy, bulging fontanelles, and neuropsychiatric symptoms. These abnormalities have been associated with the use of the penicillins, cephalosporins, sulfonamides, tetracyclines, chloramphenicol, colistin, aminoglycosides, metronidazole, isoniazid, rifampin, ethionamide, cycloserine, and dapsone. Cranial nerve toxicities, such as myopia, optic neuritis, deafness, vertigo, and tinnitus, have been associated with the use of erythromycin, sulfonamides, tetracyclines, chloramphenicol, colistin, aminoglycosides, vancomycin, isoniazid, and ethambutol. Peripheral nerve symptoms consisting of paresthesias, motor weakness, or sensory impairment have been associated with the use of the penicillins, sulfonamides, chloramphenicol, colistin, metronidazole, isoniazid, ethionamide, and dapsone. Neuromuscular blockade has been associated with the use of the tetracyclines, polymyxins, lincomycin, clindamycin, and aminoglycosides. Management generally consists of supportive therapy and immediate discontinuation of therapy with the offending drug.

Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Central Nervous System Diseases; Cephalosporins; Chloramphenicol; Clindamycin; Colistin; Cranial Nerve Diseases; Dapsone; Erythromycin; Ethambutol; Humans; Lincomycin; Metronidazole; Nervous System Diseases; Neuromuscular Junction; Penicillins; Peripheral Nervous System Diseases; Polymyxin B; Sulfonamides; Tetracyclines; Vancomycin

The authors report a case to call attention on a Neurological Accident happening in a patient with normal renal functions, after administration of a single and strong dose of Colistine. The authors report their case and make a review of the literature on the frequency of these isolated neurological (accidents) and their supposed (pathogenesis).

Topics: Adolescent; Colistin; Creatinine; Female; Humans; Nervous System Diseases; Neurotoxins; Renal Dialysis

Topics: Adult; Aged; Anti-Bacterial Agents; Colistin; Drug Hypersensitivity; Ear Diseases; Epilepsy; Female; Humans; Male; Middle Aged; Muscle Spindles; Nervous System Diseases; Penicillins; Polymyxins; Postoperative Complications

Topics: Acute Kidney Injury; Adolescent; Adult; Age Factors; Aged; Apnea; Body Weight; Colistin; Drug Hypersensitivity; Female; Follow-Up Studies; Humans; Kidney Diseases; Kidney Function Tests; Male; Middle Aged; Nausea; Nervous System Diseases; Paresthesia; Pneumonia; Prospective Studies; Pyelonephritis; Respiratory Insufficiency; Sepsis; Sex Factors; Statistics as Topic; Time Factors; Vomiting

Topics: Colistin; Humans; Kidney Diseases; Nephritis; Nephritis, Interstitial; Nervous System Diseases; Toxicology