colistin and Leukemia--Lymphoid

colistin has been researched along with Leukemia--Lymphoid* in 10 studies

Trials

2 trial(s) available for colistin and Leukemia--Lymphoid

Article	Year
Infection prophylaxis in acute leukemia: a comparison of ciprofloxacin with trimethoprim-sulfamethoxazole and colistin. Annals of internal medicine, 1987, Volume: 106, Issue:1 Fifty-six patients receiving remission induction treatment for acute leukemia were studied in a randomized trial comparing ciprofloxacin with trimethoprim-sulfamethoxazole plus colistin for prevention of infections. Both groups received amphotericin B for antifungal prophylaxis. Six major infections occurred in 28 patients receiving ciprofloxacin, and 11 major infections occurred in 28 patients receiving trimethoprim-sulfamethoxazole plus colistin. No infections caused by gram-negative bacilli were seen in the ciprofloxacin group (p less than 0.02). Ciprofloxacin prevented colonization with resistant gram-negative bacilli, but 12 resistant colonizing strains were isolated from 10 patients receiving trimethoprim-sulfamethoxazole plus colistin (p less than 0.01). Ciprofloxacin was better tolerated: 23 of 28 patients were highly compliant to the drug, compared with 15 of 28 patients in the trimethoprim-sulfamethoxazole group (p less than 0.05). These results suggest that ciprofloxacin is a promising drug for the prevention of infection in patients with granulocytopenia. Topics: Acute Disease; Agranulocytosis; Bacterial Infections; Ciprofloxacin; Colistin; Drug Combinations; Drug Resistance, Microbial; Humans; Leukemia; Leukemia, Lymphoid; Patient Compliance; Random Allocation; Sulfamethizole; Sulfathiazoles; Trimethoprim	1987
Co-trimoxazole for prevention of infection in acute leukaemia. Lancet (London, England), 1978, Aug-19, Volume: 2, Issue:8086 30 patients with acute leukaemia being treated with cytotoxic drugs were investigated in a randomised trial to determine whether oral administration of co-trimoxazole in addition to non-absorbable antibiotics would reduce the rate of infection. Three significant differences were observed between the co-trmoxazole and the control groups: (i) 15 of the 16 (94%) control patients but only 8 of the 14 (57%) patients on co-trimoxazole developed infections and required additional antibiotics intravenously; (ii) although the duration of severe neutropenia (neutrophils less than 0.1 times 10(9)/1) was similar in the two groups, control patients required intravenous antibiotics on average after 2 days of neutropenia, whereas patients receiving co-trimoxazole required these only after 12 days; and (iii) the only 2 patients who died of infection were in the control group. Prophylaxis with co-trimoxazole is important in preventing or delaying the development of infection in neutropenic patients receiving therapy for acute leukaemia. Topics: Administration, Oral; Adolescent; Adult; Aged; Clinical Trials as Topic; Colistin; Cross Infection; Drug Combinations; Drug Therapy, Combination; Framycetin; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Middle Aged; Neutropenia; Nystatin; Prospective Studies; Research Design; Sulfamethoxazole; Trimethoprim	1978

Article

Year

Infection prophylaxis in acute leukemia: a comparison of ciprofloxacin with trimethoprim-sulfamethoxazole and colistin.

Annals of internal medicine, 1987, Volume: 106, Issue:1

Fifty-six patients receiving remission induction treatment for acute leukemia were studied in a randomized trial comparing ciprofloxacin with trimethoprim-sulfamethoxazole plus colistin for prevention of infections. Both groups received amphotericin B for antifungal prophylaxis. Six major infections occurred in 28 patients receiving ciprofloxacin, and 11 major infections occurred in 28 patients receiving trimethoprim-sulfamethoxazole plus colistin. No infections caused by gram-negative bacilli were seen in the ciprofloxacin group (p less than 0.02). Ciprofloxacin prevented colonization with resistant gram-negative bacilli, but 12 resistant colonizing strains were isolated from 10 patients receiving trimethoprim-sulfamethoxazole plus colistin (p less than 0.01). Ciprofloxacin was better tolerated: 23 of 28 patients were highly compliant to the drug, compared with 15 of 28 patients in the trimethoprim-sulfamethoxazole group (p less than 0.05). These results suggest that ciprofloxacin is a promising drug for the prevention of infection in patients with granulocytopenia.

Topics: Acute Disease; Agranulocytosis; Bacterial Infections; Ciprofloxacin; Colistin; Drug Combinations; Drug Resistance, Microbial; Humans; Leukemia; Leukemia, Lymphoid; Patient Compliance; Random Allocation; Sulfamethizole; Sulfathiazoles; Trimethoprim

1987

Co-trimoxazole for prevention of infection in acute leukaemia.

Lancet (London, England), 1978, Aug-19, Volume: 2, Issue:8086

30 patients with acute leukaemia being treated with cytotoxic drugs were investigated in a randomised trial to determine whether oral administration of co-trimoxazole in addition to non-absorbable antibiotics would reduce the rate of infection. Three significant differences were observed between the co-trmoxazole and the control groups: (i) 15 of the 16 (94%) control patients but only 8 of the 14 (57%) patients on co-trimoxazole developed infections and required additional antibiotics intravenously; (ii) although the duration of severe neutropenia (neutrophils less than 0.1 times 10(9)/1) was similar in the two groups, control patients required intravenous antibiotics on average after 2 days of neutropenia, whereas patients receiving co-trimoxazole required these only after 12 days; and (iii) the only 2 patients who died of infection were in the control group. Prophylaxis with co-trimoxazole is important in preventing or delaying the development of infection in neutropenic patients receiving therapy for acute leukaemia.

Topics: Administration, Oral; Adolescent; Adult; Aged; Clinical Trials as Topic; Colistin; Cross Infection; Drug Combinations; Drug Therapy, Combination; Framycetin; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Middle Aged; Neutropenia; Nystatin; Prospective Studies; Research Design; Sulfamethoxazole; Trimethoprim

1978

Other Studies

8 other study(ies) available for colistin and Leukemia--Lymphoid

Article	Year
[Intensification of the initial therapy according to the West-Berlin protocol in acute lymphoblastic leukemia: results after 2 1/2 years in Münster (author's transl)]. Klinische Padiatrie, 1978, Volume: 190, Issue:1 Topics: Adolescent; Adrenal Cortex Hormones; Asparaginase; Bacterial Infections; Child; Child, Preschool; Colistin; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Therapy, Combination; Female; Humans; Infant; Injections, Spinal; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Remission, Spontaneous; Skull; Vincristine	1978
Advances in the management of Pseudomonas aeruginosa infections in cancer patients. European journal of cancer, 1973, Volume: 9, Issue:6 Topics: Carbenicillin; Colistin; Ecthyma; Gentamicins; Humans; Leukemia; Leukemia, Lymphoid; Lymphoma; Meningitis; Neutropenia; Pneumonia; Polymyxins; Pseudomonas aeruginosa; Pseudomonas Infections; Sepsis; Uremia	1973
Treatment of pseudomonas infections in leukemic children with carbenicillin and colistin. Current therapeutic research, clinical and experimental, 1971, Volume: 13, Issue:3 Topics: Adolescent; Carbenicillin; Child; Child, Preschool; Colistin; Cyclophosphamide; Daunorubicin; Humans; Infant; Leukemia, Lymphoid; Penicillins; Prednisone; Pseudomonas Infections; Vincristine	1971
Overdosage of colistin. The Journal of pediatrics, 1970, Volume: 77, Issue:3 Topics: Child, Preschool; Colistin; Female; Humans; Infections; Kidney; Leukemia, Lymphoid	1970
Resistance of Pseudomonas aeruginosa. Lancet (London, England), 1969, May-31, Volume: 1, Issue:7605 Topics: Child; Colistin; Drug Synergism; Humans; Leukemia, Lymphoid; Male; Meningitis; Penicillin Resistance; Penicillins; Pseudomonas aeruginosa	1969
[Allergy signs in antibody deficiency syndrome]. Medizinische Klinik, 1969, Jul-18, Volume: 64, Issue:29 Topics: Agammaglobulinemia; Aged; Colistin; Drug Eruptions; Drug Hypersensitivity; Female; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Middle Aged; Penicillins	1969
Colistin nephrotoxicity: report of a case with light and electron microscopic studies. Acta pathologica japonica, 1969, Volume: 19, Issue:1 Topics: Adolescent; Basement Membrane; Colistin; Cytoplasm; Endoplasmic Reticulum; Epithelium; Humans; Kidney; Kidney Diseases; Kidney Glomerulus; Kidney Tubules; Leukemia, Lymphoid; Male; Microscopy, Electron; Plasma Cells; Pseudomonas Infections; Rhinitis; Streptomycin	1969
USE OF GAMMA GLOBULIN INFECTION IN ACUTE-LEUKEMIA PATIENTS. JAMA, 1964, Dec-28, Volume: 190 Topics: Abscess; Cellulitis; Colistin; gamma-Globulins; Humans; Infections; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Methicillin; Neoplasms; Pharmacology; Pneumonia; Prednisone; Sepsis; Sinusitis; Statistics as Topic; Urinary Tract Infections	1964