colistin and Empyema

Polymyxin E (colistin) is a last-resort antibiotic to treat infections caused by carbapenemase-producing Enterobacteriaceae (CPE). However, reports of CPEs resistant to colistin have been increasing, and the mcr genes are emerging as resistance mechanisms. Among them, plasmid-mediate mcr-9 is known to be associated with colistin resistance, whereas reports on chromosomal mcr-9 and its association with colistin resistance in humans are few.. We identified Enterobacter asburiae harboring mcr-9 and bla. Our case report showed that mcr-9 can be present not only on plasmids but also on the chromosome in E. asburiae, and that the presence of mcr-9 on its chromosome may influence its susceptibility to colistin.

Topics: Anti-Bacterial Agents; Chromosomes; Colistin; Drug Resistance, Bacterial; Empyema; Enterobacter; Escherichia coli Proteins; Humans; Japan; Microbial Sensitivity Tests; Plasmids

Topics: Cephalosporins; Colistin; Drainage; Empyema; Enterobacter; Humans; Lung Abscess; Male; Middle Aged; Penicillins; Pseudomonas aeruginosa; Radiography, Thoracic; Streptodornase and Streptokinase; Tetracycline

Topics: Abscess; Amphotericin B; Brain Abscess; Candidiasis; Carrier State; Child; Chloramphenicol; Colistin; Deoxyribonucleases; DNA; Empyema; Enteritis; Humans; Kanamycin; Meningitis; Methicillin; Penicillins; Peritonitis; Phlebitis; Pneumonia; Pneumothorax; Pseudomonas Infections; Sepsis; Staphylococcal Infections; Sulfadiazine; Troleandomycin