colistin and Brain-Diseases

The revival of polymyxin antibiotics with the advent of multidrug resistant gram-negative bacteria in the recent decade has led to renewed interest in toxicity of this indispensable drug. We report a postoperative case of burst abdomen where colistin was started in view of Pseudomonas organism sensitive to colistin. Subsequently, the patient went into respiratory depression and encephalopathy after starting the treatment. She recovered promptly after stopping the drug.

Topics: Anti-Bacterial Agents; Brain Diseases; Colistin; Female; Humans; Neurotoxicity Syndromes; Pseudomonas; Pseudomonas Infections; Respiratory Insufficiency; Young Adult

Topics: Adolescent; Anti-Bacterial Agents; Brain Diseases; Cerebral Ventricles; Cerebrospinal Fluid Shunts; Colistin; Drug Resistance, Multiple; Humans; Injections, Spinal; Male; Pseudomonas aeruginosa; Pseudomonas Infections; Treatment Outcome

Topics: Acinetobacter; Acinetobacter Infections; Adolescent; Adult; Anti-Bacterial Agents; Brain Diseases; Carbapenems; Central Nervous System Bacterial Infections; Cerebral Ventricles; Colistin; Drug Resistance, Microbial; Encephalitis; Female; Humans; Injections, Intraventricular; Male; Middle Aged; Treatment Outcome

A myopathy caused by the activity of polymyxin E on the cell membrane was accompained by immunological manifestations. There were also disturbances of the central nervous system, contrasting with the absence of serious renal lesion.

Topics: Aged; Antigen-Antibody Reactions; Autoantibodies; Brain Diseases; Colistin; Electromyography; Fluorescent Antibody Technique; Frontal Lobe; Humans; Klebsiella Infections; Klebsiella pneumoniae; Male; Muscles; Muscular Diseases; Neural Conduction; Osteomyelitis; Paralysis

Topics: Brain Diseases; Child; Colistin; Gentamicins; Humans; Injections, Intravenous; Male; Osteomyelitis; Patella; Pseudomonas aeruginosa; Seizures

Topics: Anti-Bacterial Agents; Anticonvulsants; Brain Diseases; Burns; Child; Colistin; Coma; Drug Therapy; Electroencephalography; Humans; Neurologic Manifestations; Seizures