colistin and Appendicitis

Colistin resistance mediated by the mcr-1 gene has been reported worldwide, but to date not from the Andean region, South America. We report the first clinical isolate of Escherichia coli harbouring the mcr-1 gene in Ecuador. The strain was isolated from peritoneal fluid from a 14-year-old male with acute appendicitis, and subjected to molecular analysis. The minimum inhibitory concentration of colistin for the strain was 8 mg/ml and it was susceptible to carbapenems but resistant to tigecycline. The strain harboured mcr-1 and bla CTX-M-55 genes and was of sequence type 609. The recognition of an apparently commensal strain of E. coli harbouring mcr-1 serves as an alert to the presence in the region of this recently described resistance mechanism to one of the last line of drugs available for the treatment of multi-resistant Gram-negative infections.

Topics: Acute Disease; Adolescent; Anti-Bacterial Agents; Appendicitis; Colistin; Drug Resistance, Bacterial; Ecuador; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Humans; Male; Microbial Sensitivity Tests

Topics: Abscess; Acute Disease; Adolescent; Adult; Aged; Appendicitis; Child; Child, Preschool; Colistin; Female; Humans; Male; Methods; Middle Aged; Peritoneal Diseases; Rolitetracycline; Time Factors

Topics: Abdomen, Acute; Appendicitis; Colistin; Drug Synergism; Exudates and Transudates; Humans; Intestines; Penicillins; Peritonitis; Postoperative Care

Topics: Acute Kidney Injury; Appendicitis; Child, Preschool; Colistin; Female; Humans; Kidney Tubules; Paralysis; Postoperative Complications

Topics: Acute Disease; Anti-Bacterial Agents; Appendicitis; Child; Colistin; Humans; Infant; Peritonitis; Urinary Tract

Topics: Acute Disease; Anti-Bacterial Agents; Appendicitis; Appendix; Colistin; Humans