colistin and Anaphylaxis

colistin has been researched along with Anaphylaxis* in 3 studies

Other Studies

3 other study(ies) available for colistin and Anaphylaxis

ArticleYear
Polymyxin B and polymyxin E induce anaphylactoid response through mediation of Mas-related G protein-coupled receptor X2.
    Chemico-biological interactions, 2019, Aug-01, Volume: 308

    Polymyxin B (PMB) and polymyxin E (PME) are cyclic, peptide antibiotics which derived from various species of Paenibacillus (Bacillus) polymyxa. They are decapeptide antibiotics with an antimicrobial spectrum that includes Gram-negative bacteria, and reused as therapeutic agents due to the emergence of multidrug-resistant (MDR) Gram-positive bacteria. PMB or PME-induced anaphylactoid reactions in the clinic have been documented. However, the mechanism underlying anaphylactoid reaction induced by polymyxin has not yet been reported. Here, we report that human Mas-related G protein-coupled receptor X2 (MRGPRX2) and its mouse homologue Mas-related G protein-coupled receptor B2 (MrgprB2) are the receptors mediating the anaphylactoid response provoked by PMB and PME. We firstly investigated the anaphylactoid reactions induced by PMB and PME in LAD2 cells in vitro and in vivo, and found that treatment with PMB and PME led to significant release of mast cell granules such as histamine and β-hexosaminidase, secretion of pro-inflammatory cytokines, such as TNF-α and PGD2, and provocation of calcium flux in LAD2 cells. Furthermore, treatment with PMB and PME led to reduced release of β-hexosaminidase in MRGPRX2 knockdown-LAD2 cells, and obvious increased calcium release in MRGPRX2 overexpressing HEK293 cells, which suggested that MRGPRX2 are involved in mast cell activation provoked by PMB or PME. In vivo, MRGPRB2 knockout mice exhibited lower pseudo-allergic reactions than wild type mice. Activation of MrgprB2 also triggers increased capillary permeability and paw swelling. Our results elucidated the role of MRGPRX2 in PMB and PME-induced anaphylactoid response and suggested that MRGPRX2 as a potential therapeutic target to control the anaphylactoid reactions which triggered by PMB or PME.

    Topics: Anaphylaxis; Animals; Calcium; Cell Degranulation; Cell Line; Colistin; HEK293 Cells; Histamine; Humans; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Knockout; Polymyxin B; Receptors, G-Protein-Coupled; RNA Interference; RNA, Small Interfering

2019
ADVERSE REACTIONS TO DRUGS.
    Pennsylvania medical journal (1928), 1964, Volume: 67

    Topics: Anaphylaxis; Anti-Bacterial Agents; Aspirin; Chemical and Drug Induced Liver Injury; Chloramphenicol; Colistin; Drug Eruptions; Drug Hypersensitivity; Hepatitis; Nitrofurantoin; Novobiocin; Penicillins; Polymyxins; Protein Synthesis Inhibitors; Serum Sickness; Streptomycin; Tetracycline; Toxicology

1964
[ALLERGIC REACTIONS TO ANTIBIOTICS: CASE CONSIDERATIONS AND SEROLOGICAL RESEARCH].
    Minerva medica, 1964, Dec-15, Volume: 55

    Topics: Anaphylaxis; Anti-Bacterial Agents; Chloramphenicol; Colistin; Diagnosis; Drug Hypersensitivity; Humans; Hypersensitivity; Nystatin; Penicillins; Statistics as Topic; Streptomycin; Tetracycline; Toxicology

1964