colibactin and Prostatitis

colibactin has been researched along with Prostatitis* in 1 studies

Other Studies

1 other study(ies) available for colibactin and Prostatitis

Article	Year
Oncogenic gene fusions in nonneoplastic precursors as evidence that bacterial infection can initiate prostate cancer. Proceedings of the National Academy of Sciences of the United States of America, 2021, 08-10, Volume: 118, Issue:32 Prostate adenocarcinoma is the second most commonly diagnosed cancer in men worldwide, and the initiating factors are unknown. Oncogenic TMPRSS2:ERG (ERG+) gene fusions are facilitated by DNA breaks and occur in up to 50% of prostate cancers. Infection-driven inflammation is implicated in the formation of ERG+ fusions, and we hypothesized that these fusions initiate in early inflammation-associated prostate cancer precursor lesions, such as proliferative inflammatory atrophy (PIA), prior to cancer development. We investigated whether bacterial prostatitis is associated with ERG+ precancerous lesions in unique cases with active bacterial infections at the time of radical prostatectomy. We identified a high frequency of ERG+ non-neoplastic-appearing glands in these cases, including ERG+ PIA transitioning to early invasive cancer. These lesions were positive for ERG protein by immunohistochemistry and Topics: Atrophy; Bacterial Infections; DNA Breaks; Humans; Male; Oncogene Fusion; Peptides; Polyketides; Prostate; Prostatectomy; Prostatic Neoplasms; Prostatitis; Serine Endopeptidases; Transcriptional Regulator ERG	2021

Article

Year

Oncogenic gene fusions in nonneoplastic precursors as evidence that bacterial infection can initiate prostate cancer.

Proceedings of the National Academy of Sciences of the United States of America, 2021, 08-10, Volume: 118, Issue:32

Prostate adenocarcinoma is the second most commonly diagnosed cancer in men worldwide, and the initiating factors are unknown. Oncogenic TMPRSS2:ERG (ERG+) gene fusions are facilitated by DNA breaks and occur in up to 50% of prostate cancers. Infection-driven inflammation is implicated in the formation of ERG+ fusions, and we hypothesized that these fusions initiate in early inflammation-associated prostate cancer precursor lesions, such as proliferative inflammatory atrophy (PIA), prior to cancer development. We investigated whether bacterial prostatitis is associated with ERG+ precancerous lesions in unique cases with active bacterial infections at the time of radical prostatectomy. We identified a high frequency of ERG+ non-neoplastic-appearing glands in these cases, including ERG+ PIA transitioning to early invasive cancer. These lesions were positive for ERG protein by immunohistochemistry and

Topics: Atrophy; Bacterial Infections; DNA Breaks; Humans; Male; Oncogene Fusion; Peptides; Polyketides; Prostate; Prostatectomy; Prostatic Neoplasms; Prostatitis; Serine Endopeptidases; Transcriptional Regulator ERG

2021