colibactin and Intestinal-Polyps

Some Escherichia coli strains of phylogroup B2 harbor a (pks) pathogenicity island that encodes a polyketide-peptide genotoxin called colibactin. It causes DNA double-strand breaks and megalocytosis in eukaryotic cells and it may contribute to cancer development. Study of bacterial community that colonizes the adenomatous polyp lesion, defined as precancerous lesions, could be helpful to assess if such pathogenic bacteria possess a role in the polyp progression to cancer. In this cross-sectional study, a total of 1500 E. coli isolates were obtained from biopsies of patients presenting adenomatous colon polyps, the normal tissues adjacent to the polyp lesion and patients presenting normal mucosa. pks island frequency, phylogenetic grouping, fingerprint genotyping, and virulence gene features of pks positive (pks

Topics: Adhesins, Escherichia coli; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacterial Toxins; Biopsy; Cross-Sectional Studies; DNA, Bacterial; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Fimbriae Proteins; Genetic Variation; Genomic Islands; Genotype; Hemolysin Proteins; Humans; Intestinal Polyps; Italy; Membrane Proteins; Microbial Sensitivity Tests; Middle Aged; Molecular Epidemiology; Peptides; Phylogeny; Polyketides; Receptors, Cell Surface; Virulence; Virulence Factors