colibactin and Cell-Transformation--Neoplastic

Gut colonization by colibactin-producing bacteria is associated with colorectal cancer. A mutational signature of this genotoxin in human cancer indicates causality but only partially accounts for cell transformation. Instead, the failure of adequately resolving DNA damage causes genomic aberrations and chromosomal instability, constituting the main starting point for colibactin-driven cancer.

Topics: Cell Transformation, Neoplastic; Chromosome Aberrations; Colorectal Neoplasms; DNA Damage; Humans; Mutation; Peptides; Polyketides